Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1661

TDMS Study 05043-02 Pathology Tables

NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97
Route: GAVAGE                                                                                                     Time: 08:05:07




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  M  +  +        +  +  +  M  +  +  A  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +        +  +  M  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Carcinoma             |                                                          X               |             
      Hepatocellular Adenoma               |    X                    X                                                |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                 X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +                          +  +                  |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  M  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Squamous Cell Carcinoma              |       X                                                                  |             
      Squamous Cell Papilloma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Squamous Cell Carcinoma, Deep        |                                                                          |             
          Invasion                         |       X                                                                  |             
      Muscularis, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  +  +  M  +        +  M  +  +  +  M  M  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |       X           X                                                     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +        I  +  +  +  +  +  +  +     +  +  +|             
      Cystadenoma, Papillary               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Axillary, Histiocytic Sarcoma        |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                           X                              |             
      Inguinal, Histiocytic Sarcoma        |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                         X                                                |             
      Lumbar, Histiocytic Sarcoma          |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                         X                 X                              |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                         X                 X                              |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                           X                              |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                 X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +        +  M  +  M  +  +  +  +     M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  +  +  +  M  M        +  M  +  M  M  M  +  +     +  +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Back, Lymphoma Malignant Lymphocytic |                                                                          |             
      Head, Sarcoma                        |                                                                          |             
      Hindlimb, Rhabdomyoma                |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  M        M  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                         X                 X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     +  +  +  +        +  +  +     +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                         X                                                |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                         +                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  M     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Squamous Cell Carcinoma, Deep        |                                                                          |             
          Invasion                         |                                                                          |             
      Muscularis, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  M  +     +  M  +  M        M  M  +     M  M  M  M     +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Pars Distalis, Adenoma               |                                                          X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Cystadenoma, Papillary               |                                                                      X   |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     M  +  +     +  +  +  +        +  M  +     +  +  +  +     +  +|             
      Axillary, Histiocytic Sarcoma        |                            X                                             |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Histiocytic Sarcoma        |                            X                                             |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Histiocytic Sarcoma          |                            X                                             |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                            X                                             |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                            X                                             |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Histiocytic Sarcoma           |                            X                                             |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     M  +  +     +  +  +  +        +  M  +     M  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  +  +     +  M  +  M        +  +  +     M  +  M  +     M  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +     +  +  +  +        +  M  M     +  M  +  M     +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Back, Lymphoma Malignant Lymphocytic |                                                          X               |             
      Head, Sarcoma                        |                                                                          |             
      Hindlimb, Rhabdomyoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                 X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  M  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +     +  +  +  +  +  +                                             |  43        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +     +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     M  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  M  +  +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X        X                                                |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   7        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +                                             |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X        X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +                                             |  49        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +                                             |  49        |
      Squamous Cell Carcinoma, Deep        |                                                                          |            |
          Invasion                         |                                                                          |          1 |
      Muscularis, Lymphoma Malignant       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  M  +     +  +  +  +  +  +                                             |  49        |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  M  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +     M  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  M  +  M  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  M  +                                             |  46        |
      Pars Distalis, Adenoma               |                X     X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  M  +  +                                             |  48        |
      Cystadenoma, Papillary               |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X        X                                                |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Axillary, Histiocytic Sarcoma        |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Inguinal, Histiocytic Sarcoma        |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Histiocytic Sarcoma          |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mandibular, Histiocytic Sarcoma      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      | X                       X                                                |          3 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          2 |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      | X              X                                                         |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          3 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic| X                                                                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +                                             |  46        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X        X                                                |          4 |
      Lymphoma Malignant Mixed             |       X                                                                  |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X        X                                                |          5 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M     +  M  M  M  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     M  +  +  +  M  +                                             |  36        |
      Carcinoma                            |                      X                                                   |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   3        |
      Back, Lymphoma Malignant Lymphocytic |                                                                          |          1 |
      Head, Sarcoma                        |                         X                                                |          1 |
      Hindlimb, Rhabdomyoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X        X                                                |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  M  +                                             |  45        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +     +                                             |   2        |
      Adenoma                              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X        X                                                |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M     +  +  +  +  +  +                                             |  47        |
      Lymphoma Malignant Lymphocytic       |                X        X                                                |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X              X        X                                                |          5 |
      Lymphoma Malignant Mixed             |       X                                                                  |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +                 M                    +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +     +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                                                   X     X|             
      Hepatocellular Adenoma               |          X                                                     X         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                                      +      |             
      Histiocytic Sarcoma                  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +     +           +     +                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +     +                 M                           |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +     +        +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +     +        +        +              +            |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +  +     +        +        +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +     +                 +                           |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      M     +                 +                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +     +                 +                           |             
      Pars Distalis, Adenoma               |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +     +     +        +  +     +        +           +      |             
      Luteoma                              |                                              X                           |             
      Teratoma                             |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +                    +  +  +        +     +  +        +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  M     +                 +        +  +        +      |             
      Lumbar, Histiocytic Sarcoma          |                                                                   X      |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                   X      |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +              M     +                 +           +        +      |             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                    +     +                 +                           |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +     +                 +                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                    M     +                 +                           |             
      Carcinoma                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +           +     +  +              +        +  +  +  +  +     +|             
      Fibrosarcoma                         |                                                                          |             
      Fibrosarcoma, Multiple               |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                             X            |             
      Vulva, Squamous Cell Carcinoma,      |                                                                          |             
          Noninvasive                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +     +                 +           +               |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                                                        X               |             
                                            __________________________________________________________________________|             
   Nose                                    |                      M     +                 +                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +     +  +        +  +  +     +     +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Renal Tubule, Carcinoma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                   M                       M        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   M                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +     +  +  A     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +     +  +  A     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +     +  +  +     +  +  +  +     +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                     X     X                              |             
      Hepatocellular Adenoma               |                                        X                                 |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +                       +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +     +           +     +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +     +           +     +        +  +  +     +        +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +                       +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           +                    +  +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +                    +  +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           +                    M  +        M  +  +              +|             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +                       +        +  +  +              M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +                       +        +  +  +              +|             
      Pars Distalis, Adenoma               |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Fibrosarcoma                         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +           +  +                 +  +        +  +  +              +|             
      Luteoma                              |                                                                          |             
      Teratoma                             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                    +  +  +               |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +              +           +        +  +     +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +     +              +  +     +  +  +  +     +  +     +|             
      Lumbar, Histiocytic Sarcoma          |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     | X                                                              X         |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed| X                                                              X         |             
      Pancreatic, Lymphoma Malignant Mixed | X                       X                                                |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                 X                        |             
      Renal, Lymphoma Malignant Mixed      | X                                                              X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +                    +  +     +  +  +  +     +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Mixed             | X                                                              X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +     +  +     +           +  +  +     +  +  +  +     +        +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             | X                       X                                      X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   M     +                 M        M  +  +              +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   +                       +        M  M  +           +  +|             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +        M     +  +                    +  +     +  +  +  +              +|             
      Fibrosarcoma                         |                                                                         X|             
      Fibrosarcoma, Multiple               |                X                                                         |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
      Vulva, Squamous Cell Carcinoma,      |                                                                          |             
          Noninvasive                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +  +                 +  +     +  +  +  +              +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +        +  +  +  +     +     +  +  +        +  +  +           +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +                       M        +  +  M              +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +     +  +  +     +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             | X                       X                                      X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                    +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                    +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +                                             |  50        |
      Hemangioma                           |             X                                                            |          1 |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                    +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                    +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                    +  +                                             |  20        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                    +  +                                             |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                    +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                    +  +                                             |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                    +  +                                             |  12        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                    +  M                                             |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +              M  +                                             |  13        |
      Pars Distalis, Adenoma               |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                    +  +                                             |  13        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +     +        +  +                                             |  25        |
      Luteoma                              |                                                                          |          1 |
      Teratoma                             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +                       +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                 +  +                                             |  26        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +     +  +                                             |  27        |
      Lumbar, Histiocytic Sarcoma          |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                   X                                                      |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Histiocytic Sarcoma           |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           +     +  +                                             |  23        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X           X                                                      |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +     +     +  +                                             |  24        |
      Hemangiosarcoma                      |                         X                                                |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                    +  +                                             |  10        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M                    +  +                                             |  10        |
      Carcinoma                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +        +  +                                             |  31        |
      Fibrosarcoma                         |                                                                          |          1 |
      Fibrosarcoma, Multiple               |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
      Vulva, Squamous Cell Carcinoma,      |                                                                          |            |
          Noninvasive                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +     +        +  +                                             |  20        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          1 |
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
      Adenoma                              |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +     +  +                                             |  39        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                    +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +     +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X           X                                                      |          3 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     M  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Hepatocellular Adenoma               |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Squamous Cell Papilloma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +     +  +  +  +     +  +  +     +     +  +  +     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +     +  M  M  M     +  +  +     M     +  +  +     M  M     +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +     +  M  +     +     +  +  +     +  +     +  M  M|             
      Pars Distalis, Adenoma               |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Luteoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +  +                                   +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Hemangioma                           |             X                                                            |             
      Endometrium, Polyp Stromal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     M  +  +|             
      Mandibular, Lymphoma Malignant Mixed |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  M  +  +     +  M  +     +     +  +  +     +  +     M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             | X                 X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                   X                          X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  M     +  +  +     +     +  +  +     A  +     +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  M  M  M     +  +  +     +     M  +  +     +  M     M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +     +  +  +     +     M  +  +     +  +     +  +  +|             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
      Mediastinum, Hemangioma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +     +  M  +     +     +  +  +     +  +     +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             | X                 X                          X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X        X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  M  M  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  M  +  +  +  M  M     +  +     +  +  M     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  M  +  +  +|             
      Pars Distalis, Adenoma               | X                    X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  M  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Luteoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |       +  +                                +                 +           +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Endometrium, Polyp Stromal           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Mandibular, Lymphoma Malignant Mixed |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X        X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  +     +  +     M  +  +     +  +  M  M  M|             
      Lymphoma Malignant Mixed             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  +  +  +  +  +  +  +     +  +     +  +  +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Fibrosarcoma                         |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X              X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Hemangioma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  M  +  M  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                X        X|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X        X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +     +  +  M  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M     +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                      X                                                   |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M     +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +                                             |  50        |
      Squamous Cell Papilloma              |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M     +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +     +  M  M  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  M  +     +  +  +  +                                             |  44        |
      Pars Distalis, Adenoma               |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +     M  +  +  +                                             |  44        |
      Luteoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |             +                                                            |   9        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +                                             |  49        |
      Hemangioma                           |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +                                             |  49        |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +                                             |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M     +  +  +  +                                             |  39        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +     +  M  +  M                                             |  37        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +                                             |  49        |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mediastinum, Hemangioma              |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Hemangiosarcoma, Metastatic          |                            X                                             |             
      Hepatocellular Carcinoma             |    X                                                                     |             
      Hepatocellular Adenoma               | X  X                    X                 X        X              X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Squamous Cell Papilloma              |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pheochromocytoma Benign              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  M  +  +  +  +  +     +  +  +  M  M  M     M  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  M  +     +  +  +  +  M  +     +  +  +  M   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +   |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +     +  +  +  M   |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +     +  +  +  M   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Hemangiosarcoma                      |                                                 X  X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  M  M  +     +  +  +  M  +  M     +  M  +  +   |             
      Thymoma Benign                       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M     M  +  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Fibrosarcoma                         |                                                                          |             
      Fibrosarcoma, Multiple               |                                           X                              |             
      Hemangiosarcoma                      |                            X                                             |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Sarcoma, Poorly |                                                                          |             
          Differentiated                   |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +     M  +  +  +  +  +     +  +  +  M   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                             +   |             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                           X                              |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     M  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  M     +     A  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  M  +  +  +  +  +  +     +     A  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic          |                                                                          |             
      Hepatocellular Carcinoma             |       X              X     X                                             |             
      Hepatocellular Adenoma               |                         X     X     X                                X   |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                        X     X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Pheochromocytoma Benign              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  M  +  M  +  +  +  M  +  +  +  M     +     +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     M  +  M  +  +  +  +  +  +  +  +  +     +     +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                X                                                         |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +        +                             +                    +|             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  M  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  M  +  +  +  +  +     +     +  M  M  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mediastinal, Histiocytic Sarcoma     |                                                    X                     |             
      Mediastinal, Lymphoma Malignant Mixed|                            X                                             |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                            X                                             |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  M  +  +  +  +  +     +     +  M  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                  X     X     X                           |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                        X     X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M  M  +  +  M  M  +  M  +  +  +  +     +     +  M  M  M  +  M  +  M|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M  M  M  M  M  M  M  M     M     M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                        X                                 |             
      Fibrosarcoma, Multiple               |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Squamous Cell Papilloma              |                               X                                          |             
      Subcutaneous Tissue, Sarcoma, Poorly |                                                                          |             
          Differentiated                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X           X                                          |             
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     M  +  +  +  +  +  +  +  M  +  +  +     +     M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  M  +  +  +  +  +  +  +  +  +     +     +  +  A  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                  X     X     X                           |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +        +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +        +        +  +  +  M                                             |  46        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +        +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +        +  +  +  +                                             |  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +        +  +  +  +                                             |  45        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +        +  +  +  +                                             |  50        |
      Hemangiosarcoma, Metastatic          |                                                                          |          1 |
      Hepatocellular Carcinoma             |                            X                                             |          5 |
      Hepatocellular Adenoma               | X                                                                        |         11 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +        +  +  +  +                                             |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +        +  +  +  +                                             |  50        |
      Squamous Cell Papilloma              |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +        M        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +        M        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +        M        +  +  +  +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Pheochromocytoma Benign              | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +        +  M  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        I        +  +  M  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +        +  +  +  +                                             |  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +        +  +  +  M                                             |  44        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +        +  +  +  M                                             |  44        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +        +  +  +  +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M        +        M  +  +  M                                             |  29        |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M        M        M  M  M  M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +        +  +  +  +                                             |  49        |
      Fibrosarcoma                         |                                                                          |          1 |
      Fibrosarcoma, Multiple               |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma, Poorly |                                                                          |            |
          Differentiated                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +        +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                            X                                             |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        M        +  +  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +        +  +  +  +                                             |  50        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +        +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +        +        +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +           M                 +           +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  M  +           +                 +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  M  +  +  +           +                 +           +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  M  A  +           +              +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |             X                                                            |             
      Hemangioma                           |                      X                                                   |             
      Hepatocellular Carcinoma             |                                                    X                 X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X  X     X           X        X     X              X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                  +      |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +           +                 +           +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +  +  +  +  +           +                 +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +  +  +  +  +           +                 +        +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +  +  +  +  +           +                 +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  M  M           +                 M           +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +  +  +  M  +           +                 +        +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +  +                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +  +        +                                               +|             
                                            __________________________________________________________________________|             
   Prostate                                |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +  +  +  +  +           +                 +        +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |                +  +  +  +  +           +                 +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +           +                 +           +  +|             
      Hemangiosarcoma, Metastatic          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  M  +  +  +     +        +     +  +     +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Harderian Gland                 |             X                                                            |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +              +  +  +  M  +  +  +     +        +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +        +              +  +           +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  M  +           +                 M           +  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                         M  M           M                 M              M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +        +  +  +  +  +     +     +                 +        +  +  +|             
      Fibrosarcoma                         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +     +     +           +     +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +  +  +  +  +  +        +  +                 +     +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                                                X         |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  M  +           +                 +           M  M|             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Carcinoma                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +           +           M  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |       X                                X                 X               |             
      Hepatocellular Carcinoma, Multiple   |    X                                                                     |             
      Hepatocellular Adenoma               |                                  X     X  X     X           X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +           +           +  +              +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +           +           +           +  +           +  +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +           +           +  +           +  +  +        +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +           +           +  +              +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                M           +           M  +              M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                        +                    +           +|             
                                            __________________________________________________________________________|             
   Prostate                                |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +        +           +  +        +  +              +               |             
                                            __________________________________________________________________________|             
   Testes                                  |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +           +           +  +              +               |             
      Hemangiosarcoma, Metastatic          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +           +  +  +  +  +  +  +  +        +  +  +         |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Harderian Gland                 |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +           +     +  +  +  +  +  +        +  +  +         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +           +  +        +  +              +               |             
      Hemangiosarcoma                      |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +           +           +  +              +               |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           M                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +           +     +     +  +  +  +        +  +        +  +|             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +           +        +     +  +     +                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +           +           +  +              +               |             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +           M           +  +              +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +           +  +  +  +  +  +  +  +  +     +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +  +                                                |  50        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          5 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                      X  X                                                |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                    +                                                   |  16        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                 +                                                      |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +                                                      |  23        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                 +                                                      |  22        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M                       +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  19        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  16        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  15        |
      Hemangiosarcoma, Metastatic          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +        +                                                   |  36        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Mandibular, Carcinoma, Metastatic,   |                                                                          |            |
           Harderian Gland                 |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +                                                            |  32        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                    +                                                   |  19        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  11        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +                                                         |  29        |
      Fibrosarcoma                         | X              X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                         |  19        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  19        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +  +                                                |  48        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +     +  +  +  +  +                                                |  50        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  M     +  M  +     M     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +     +  +  +  +  +  +  +  +     +  +  M     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  M  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                            X                    X                    X   |             
      Hepatocellular Adenoma               |    X  X              X                                X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  M  +     +  +  +     +     +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  M  +  +  +  M     +  M  M     +     M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
      Follicular Cell, Carcinoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                   +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  M     +  +  +  +  +  M  +  +     +  +  +     +     +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +     +  +  +  +  M  +  M  +     +  +  M     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  M  M  M  M     M  M  M     M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Fibrosarcoma                         | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
      Hemangiosarcoma                      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                    X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M     +  +  +  +  M  +  +  +     +  M  +     M     M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Schwannoma Malignant                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Renal Tubule, Adenoma                |    X                       X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  M  +  +  +  +     +  M  M  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  +  +     M  +  +  M  M  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +  +  +  +  A  +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  M  +  +  M  +     M  +  M  +  +  +     +  M  M  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  M  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +              +     +                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |       X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X     X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  +  +  M  +  M  +     M  +  M  +  A  M     M  +  M  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M  M  M     M  M  M  M  M  M     M  +  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Fibrosarcoma                         |             X           X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                    X  X                                   X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  M  +  +  M     +  M  +  +  I  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  M  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
      Renal Tubule, Adenoma                |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                      X                                      X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X     X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +        +     +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +        +     A  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +        +     A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +        +     A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +        +     A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +        +     A  +                                             |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +        +     A  +                                             |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +        +     +  +                                             |  50        |
      Hemangiosarcoma                      |                         X                                                |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +        +     +  +                                             |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +        +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +        +     +  +                                             |  50        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +        +     +  +                                             |  49        |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +        +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +        +     +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +        +     +  +                                             |  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +        +     +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +        +     +  +                                             |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +        +     +  +                                             |  49        |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +        +     +  +                                             |  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +        +     +  +                                             |  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +        M     M  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M        M     M  M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +        +     +  +                                             |  50        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                   X                                                      |          1 |
      Fibrosarcoma                         |                            X                                             |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05043-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:05:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +        +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +        +     +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          7 |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                   X                                                      |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  M  +        +     +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +        +     +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +        +     +  +                                             |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +        +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +        +     +  +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------                                      

--multipart-boundary
Content-type: text/plain
Range: bytes 613785-613785/613785


--multipart-boundary--