TDMS Study 05043-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05043 2,4-DIAMINOPHENOL DIHYDROCHLORIDE TIME: 19:08:39
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: C60026
CONT: N01CP9561903 CAS: 137-09-7
PATHOLOGIST: S. WYAND S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05043 2,4-DIAMINOPHENOL DIHYDROCHLORIDE TIME: 19:08:39
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: C60026
CONT: N01CP9561903 CAS: 137-09-7
PATHOLOGIST: S. WYAND S. EUSTIS
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 113 147 157 204 214 328 469 483 483 537 |
| 543 563 602 607 621 630 669 670 685 719 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .019 G/ KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 98 102 233 449 483 518 570 571 590 602 |
| 607 613 617 617 624 719 721 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .038 G/ KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 136 378 453 470 568 579 603 606 613 621 |
| 657 679 688 694 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
==================================================================================
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 72 | 100.0 95.0 91.7 90.0 90.0 83.9 79.8 75.7 69.5 61.4 |
| | |
| | |
|.019 | 100.0 96.7 95.0 95.0 95.0 91.3 89.3 81.2 71.0 67.0 |
|G/ KG 72 | |
| | |
|.038 | 100.0 98.3 98.3 98.3 96.7 93.0 93.0 86.9 78.8 72.8 |
|G/ KG 72 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 72 .019 .038 |
| G/ KG 72 G/ KG 72 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.4% 67.0% 72.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.199N P=0.610N P=0.231N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 472.2 513.8 553.2 |
|NATURAL DEATHS (C) | (45.2) (46.3) (40.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 598.7 623.4 643.3 |
|(STANDARD ERROR) | (22.5) (20.0) (16.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 321 340 376 400 454 458 542 558 621 656 |
| 670 705 710 722 722 726 |
| CENSORED DEATHS |
| 453 453 453 453 453 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .019 G/ KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 71 256 330 330 337 410 471 516 592 619 |
| 620 631 660 683 692 700 704 713 726 |
| CENSORED DEATHS |
| 453 453 453 453 453 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .038 /G KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 245 288 288 327 327 340 410 430 441 443 |
| 479 516 531 592 614 659 661 662 662 667 |
| 667 688 |
| CENSORED DEATHS |
| 453 453 453 453 453 453 453 453 453 453 |
| |
==================================================================================
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 72 | 100.0 100.0 100.0 96.7 93.3 89.3 87.2 85.2 81.2 69.0 |
| | |
| | |
|.019 | 98.3 98.3 96.7 91.7 90.0 88.0 85.9 83.9 75.7 63.4 |
|G/ KG 72 | |
| | |
|.038 | 100.0 100.0 98.3 90.0 88.3 81.3 77.1 75.0 64.6 58.3 |
|/G KG 72 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 72 .019 .038 |
| G/ KG 72 /G KG 72 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 69.0% 63.4% 58.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.174 P=0.603 P=0.208 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 561.3 529.5 497.1 |
|NATURAL DEATHS (C) | (37.4) (43.6) (32.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 638.3 619.8 598.0 |
|(STANDARD ERROR) | (17.3) (20.2) (19.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 72 = 1
.019 G/ KG 72 = 2
.038 G/ KG 72 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 2 1 31 3
|
| 2 1 1 2 3 3
95 + 1 1 2 2 3
| 11 2 2
| 3 3
| 1 1 2 2 33
P 90 + 1 1
E | 2 23 3
R | 1 1
C |
E 85 + 2 2 33
N | 1 1 22
T | 33
| 11 22 3 3
S 80 + 1 1
U | 22 3 3
R | 1 1 22
V | 11 3 3
I 75 + 33
V | 1 1
A | 22 3 3
L | 11 2
70 + 1 1
|
| 2 2
|
65 + 1 1
| 1 1
|
| 1 1
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 72 = 1
.019 G/ KG 72 = 2
.038 /G KG 72 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 2 3 1 1
|
| 2 21 1
95 + 3 3 1 1
| 22 1 1
|
| 3 2 2 11
90 + 3 2 2
| 3 3 1 1
P | 2 2 1 1
E | 33 2 2
R 85 + 33 1 1
C | 3 3 2 1 1
E |
N | 3 3 1 1
T 80 + 2 2
| 3 3 1 1
S | 3 3 2 2 11
U | 2 2
R 75 + 3 3 1 1
V | 22
I | 3 3
V | 22
A 70 + 22
L | 1 1
| 22
|
65 + 33 2 2
| 2 2
|
|
60 + 3 3
| 3 3
|
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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