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TDMS Study 05043-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE


NTP Experiment-Test: 05043-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 17:45:26




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           12           16                                                  
    Dead                                               7            6            2                                                  
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           32           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (8)          (11)         (8)                                                 
      Mucosa, Pigmentation                                          1 (9%)                                                          
   Intestine Large, Colon                             (9)          (14)         (9)                                                 
      Parasite Metazoan                                                          1 (11%)                                            
   Intestine Large, Rectum                            (8)          (11)         (7)                                                 
      Parasite Metazoan                                             1 (9%)                                                          
   Intestine Small, Duodenum                          (49)         (50)         (50)                                                
      Lamina Propria, Inflammation, Acute                                        1 (2%)                                             
      Lamina Propria, Pigmentation                                 50 (100%)    50 (100%)                                           
   Liver                                              (50)         (30)         (50)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Basophilic Focus                                36 (72%)     19 (63%)     40 (80%)                                            
      Clear Cell Focus                                 3 (6%)                    5 (10%)                                            
      Congestion                                                    2 (7%)                                                          
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change                                    14 (28%)     12 (40%)      9 (18%)                                            
      Granuloma                                        1 (2%)                                                                       
      Hematocyst                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (3%)                                                          
      Hemorrhage, Multifocal                                        1 (3%)                                                          
      Hepatodiaphragmatic Nodule                       5 (10%)      3 (10%)      5 (10%)                                            
      Inflammation, Chronic                            3 (6%)                                                                       
      Inflammation, Granulomatous                      4 (8%)       2 (7%)      10 (20%)                                            
      Mixed Cell Focus                                 1 (2%)       1 (3%)       1 (2%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Necrosis, Multifocal                                          1 (3%)                                                          
      Bile Duct, Hyperplasia                          25 (50%)     10 (33%)     27 (54%)                                            
      Centrilobular, Inflammation, Acute               1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Midzonal, Necrosis                               1 (2%)                                                                       
      Sinusoid, Embolus Bacterial                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (6)          (5)          (4)                                                 
      Inflammation, Chronic                            1 (17%)                   1 (25%)                                            
      Fat, Necrosis, Focal                             3 (50%)      5 (100%)     2 (50%)                                            
   Pancreas                                           (49)         (13)         (50)                                                
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Acinus, Atrophy                                  5 (10%)                   4 (8%)                                             
      Acinus, Hyperplasia, Focal                       1 (2%)                    5 (10%)                                            
      Acinus, Hypertrophy, Focal                                                 1 (2%)                                             
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Duct, Cyst                                                                 1 (2%)                                             
      Duct, Hyperplasia                                                          1 (2%)                                             
      Serosa, Neovascularization, Diffuse              1 (2%)                                                                       
   Salivary Glands                                    (21)         (12)         (28)                                                
      Embolus Bacterial                                1 (5%)                                                                       
   Stomach, Forestomach                               (50)         (14)         (50)                                                
      Acanthosis                                                                 7 (14%)                                            
      Pigmentation                                                  1 (7%)       9 (18%)                                            
      Ulcer                                            2 (4%)       3 (21%)      3 (6%)                                             
   Stomach, Glandular                                 (48)         (13)         (49)                                                
      Edema                                                                      1 (2%)                                             
      Embolus Bacterial                                1 (2%)                                                                       
      Erosion, Focal                                                             1 (2%)                                             
      Hyperplasia, Focal                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (49)                                                
      Cardiomyopathy                                  16 (32%)      2 (15%)     17 (35%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Interstitium, Embolus Bacterial                  1 (2%)                                                                       
      Ventricle, Fibrosis                                           1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (15)         (50)                                                
      Capsule, Degeneration                                         1 (7%)                                                          
   Adrenal Gland, Cortex                              (50)         (15)         (50)                                                
      Congestion                                                    1 (7%)       1 (2%)                                             
      Degeneration                                    12 (24%)      2 (13%)      5 (10%)                                            
      Degeneration, Focal                                                        1 (2%)                                             
      Embolus Bacterial                                1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       1 (7%)       2 (4%)                                             
      Hyperplasia, Focal                               3 (6%)                    1 (2%)                                             
      Hypertrophy                                                                1 (2%)                                             
      Necrosis                                         1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (47)         (15)         (48)                                                
      Congestion                                                    1 (7%)                                                          
      Hyperplasia                                      4 (9%)                    1 (2%)                                             
      Hyperplasia, Focal                               3 (6%)       1 (7%)                                                          
   Islets, Pancreatic                                 (49)         (14)         (50)                                                
      Hyperplasia                                      2 (4%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Cyst                                             3 (6%)                    1 (2%)                                             
      Pars Distalis, Angiectasis                       2 (4%)       3 (6%)       2 (4%)                                             
      Pars Distalis, Cyst                              3 (6%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Embolus Bacterial                 1 (2%)                                                                       
      Pars Distalis, Hemorrhage                        2 (4%)                                                                       
      Pars Distalis, Hyperplasia, Focal                3 (6%)       7 (14%)      5 (10%)                                            
   Thyroid Gland                                      (50)         (12)         (50)                                                
      Embolus Bacterial                                1 (2%)                                                                       
      C-Cell, Hyperplasia                             10 (20%)                   2 (4%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Necrosis                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (12)         (17)         (9)                                                 
      Inflammation, Chronic                                         1 (6%)                                                          
      Inflammation, Suppurative                        1 (8%)       1 (6%)       1 (11%)                                            
      Duct, Cyst                                       1 (8%)                                                                       
   Ovary                                              (49)         (15)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)       1 (7%)                                                          
   Uterus                                             (50)         (15)         (50)                                                
      Endometriosis                                                              1 (2%)                                             
      Hydrometra                                                    1 (7%)       1 (2%)                                             
      Cervix, Hyperplasia, Cystic                      1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                 2 (4%)                    5 (10%)                                            
      Lumen, Hemorrhage                                                          1 (2%)                                             
      Wall, Necrosis                                                             1 (2%)                                             
   Vagina                                             (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (49)         (49)         (50)                                                
      Lumbar, Cyst                                                  1 (2%)                                                          
      Mediastinal, Congestion                          1 (2%)                    1 (2%)                                             
      Mediastinal, Pigmentation, Hemosiderin           3 (6%)                    2 (4%)                                             
      Pancreatic, Pigmentation                         2 (4%)      35 (71%)     33 (66%)                                            
      Renal, Congestion                                                          1 (2%)                                             
   Lymph Node, Mandibular                             (44)         (10)         (46)                                                
      Congestion                                       1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Pigmentation                                                               1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (49)         (50)                                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Pigmentation                                    32 (65%)     26 (53%)     45 (90%)                                            
      Pigmentation, Hemosiderin                        2 (4%)                                                                       
   Spleen                                             (50)         (20)         (50)                                                
      Embolus Bacterial                                1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       4 (20%)      2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                        2 (4%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (27)         (29)         (19)                                                
      Hyperplasia                                      3 (11%)      1 (3%)                                                          
      Hyperplasia, Cystic                              4 (15%)      5 (17%)      1 (5%)                                             
   Skin                                               (12)         (13)         (9)                                                 
      Face, Abscess                                                              1 (11%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Embolus Bacterial                                1 (2%)                                                                       
      Cerebrum, Perivascular, Inflammation             1 (2%)                                                                       
   Spinal Cord                                                     (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .0125 G/     .025G/KG                                               
                                                   72VF         KG 72LF       72HF                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (50)                                                
      Adenomatosis                                     2 (4%)                    1 (2%)                                             
      Congestion                                       5 (10%)      7 (41%)      2 (4%)                                             
      Hemorrhage, Focal                                             1 (6%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (6%)                                                          
      Capillary, Embolus Bacterial                     1 (2%)                                                                       
      Interstitium, Inflammation, Chronic                                        1 (2%)                                             
   Nose                                               (9)          (12)         (6)                                                 
      Nasolacrimal Duct, Inflammation, Chronic         1 (11%)                   1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (7)          (3)                                                 
      Lens, Mineralization                                                       2 (67%)                                            
   Harderian Gland                                    (1)          (1)          (1)                                                 
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Nephropathy                                     31 (62%)     39 (78%)     42 (84%)                                            
      Capillary, Embolus Bacterial                     1 (2%)                                                                       
      Cortex, Cyst                                     2 (4%)                                                                       
      Papilla, Necrosis, Diffuse                                    1 (2%)                                                          
      Renal Tubule, Hyperplasia, Focal                 1 (2%)       1 (2%)       5 (10%)                                            
      Renal Tubule, Pigmentation, Hemosiderin          1 (2%)      48 (96%)     49 (98%)                                            
   Urinary Bladder                                    (49)         (49)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Submucosa, Inflammation, Granulomatous                        1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           11           19                                                  
    Dead                                              12           16           15                                                  
    Accident                                                        1                                                               
    Gavage Death                                                    1                                                               
  Survivors                                                                                                                         
    Dead                                               1                                                                            
    Terminal Sacrifice                                23           20           16                                                  
    Terminal Sacrifice                                              1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (18)         (50)                                                
      Periesophageal Tissue, Inflammation,                                                                                          
          Suppurative                                               1 (6%)                                                          
   Intestine Large, Cecum                             (11)         (18)         (22)                                                
      Parasite Metazoan                                1 (9%)                                                                       
      Colon, Parasite Metazoan                                                   1 (5%)                                             
   Intestine Large, Colon                             (11)         (19)         (22)                                                
      Parasite Metazoan                                4 (36%)      2 (11%)      2 (9%)                                             
   Intestine Large, Rectum                            (11)         (19)         (21)                                                
      Parasite Metazoan                                1 (9%)       1 (5%)                                                          
   Intestine Small, Duodenum                          (47)         (50)         (50)                                                
      Lamina Propria, Pigmentation                                 50 (100%)    50 (100%)                                           
   Liver                                              (50)         (31)         (50)                                                
      Basophilic Focus                                21 (42%)      5 (16%)     17 (34%)                                            
      Clear Cell Focus                                10 (20%)                   7 (14%)                                            
      Congestion                                       2 (4%)       2 (6%)       4 (8%)                                             
      Fatty Change                                    26 (52%)     18 (58%)     17 (34%)                                            
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (3%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       5 (16%)      1 (2%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Bile Duct, Hyperplasia                          40 (80%)     20 (65%)     41 (82%)                                            
      Centrilobular, Degeneration                                                1 (2%)                                             
   Mesentery                                          (7)          (8)          (4)                                                 
      Artery, Inflammation, Acute                                                1 (25%)                                            
      Artery, Inflammation, Chronic                                 1 (13%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis, Focal                             5 (71%)      5 (63%)      4 (100%)                                           
   Pancreas                                           (50)         (22)         (50)                                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Acinus, Atrophy                                  8 (16%)      3 (14%)      3 (6%)                                             
      Acinus, Hyperplasia                              5 (10%)                   2 (4%)                                             
      Acinus, Hyperplasia, Focal                       3 (6%)                    4 (8%)                                             
      Acinus, Vacuolization Cytoplasmic                1 (2%)                                                                       
      Artery, Hypertrophy                              2 (4%)                    1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)       1 (5%)       1 (2%)                                             
      Artery, Thrombosis                               1 (2%)                                                                       
      Artery, Media, Hyperplasia                                    1 (5%)                                                          
      Duct, Ectasia, Multifocal                                     1 (5%)                                                          
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Stomach                                            (49)         (23)         (50)                                                
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (23)         (50)                                                
      Acanthosis                                       4 (8%)       1 (4%)       4 (8%)                                             
      Pigmentation                                                  2 (9%)       6 (12%)                                            
      Pigmentation, Focal                                           1 (4%)                                                          
      Ulcer                                            2 (4%)       3 (13%)      6 (12%)                                            
   Stomach, Glandular                                 (49)         (23)         (50)                                                
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Muscularis, Inflammation, Chronic                             1 (4%)                                                          
      Serosa, Inflammation, Chronic                                 1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (22)         (50)                                                
      Cardiomyopathy                                  40 (80%)     10 (45%)     30 (60%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                                         2 (9%)                                                          
      Artery, Myocardium, Inflammation, Chronic                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Degeneration                                                  1 (2%)                                                          
      Hyperplasia, Focal                                            5 (10%)      5 (10%)                                            
      Hypertrophy                                                   4 (8%)       1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
      Vacuolization Cytoplasmic                        7 (14%)     12 (24%)     12 (24%)                                            
      Vacuolization Cytoplasmic, Diffuse               2 (4%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)       2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Hyperplasia, Focal                               2 (4%)       2 (4%)       5 (10%)                                            
   Islets, Pancreatic                                 (50)         (22)         (50)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (48)         (12)         (44)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Pars Distalis, Angiectasis, Focal                1 (2%)       1 (2%)                                                          
      Pars Distalis, Cyst                              2 (4%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                3 (6%)      10 (20%)      8 (16%)                                            
   Thyroid Gland                                      (50)         (20)         (50)                                                
      C-Cell, Hyperplasia                              4 (8%)       1 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (17)         (24)         (26)                                                
      Inflammation, Chronic                           10 (59%)      4 (17%)      4 (15%)                                            
      Inflammation, Suppurative                                     1 (4%)                                                          
      Duct, Cyst                                       1 (6%)                    1 (4%)                                             
   Prostate                                           (49)         (19)         (50)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic                                         1 (5%)                                                          
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                       19 (39%)      5 (26%)     11 (22%)                                            
   Seminal Vesicle                                    (50)         (25)         (50)                                                
      Dilatation                                       1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Hyperplasia                   2 (4%)       4 (8%)                                                          
      Seminiferous Tubule, Degeneration                7 (14%)      3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
      Lumbar, Hyperplasia, Lymphoid                                 1 (2%)                                                          
      Mediastinal, Congestion                          5 (10%)      2 (4%)       3 (6%)                                             
      Mediastinal, Cyst                                                          1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Pigmentation                        1 (2%)       3 (6%)       1 (2%)                                             
      Pancreatic, Cyst                                                           1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                                     22 (44%)     21 (42%)                                            
      Renal, Congestion                                                          1 (2%)                                             
      Renal, Pigmentation                                           1 (2%)                                                          
   Lymph Node, Mandibular                             (49)         (14)         (47)                                                
      Hyperplasia, Plasma Cell                         3 (6%)       1 (7%)       4 (9%)                                             
   Lymph Node, Mesenteric                             (49)         (49)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Necrosis, Focal                                                            1 (2%)                                             
      Pigmentation                                    20 (41%)     22 (45%)     42 (84%)                                            
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (50)         (29)         (50)                                                
      Congestion                                                    2 (7%)                                                          
      Cyst                                                                       1 (2%)                                             
      Ectopic Tissue                                                1 (3%)                                                          
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (3%)                                                          
      Hyperplasia, Nodular                                                       1 (2%)                                             
      Hyperplasia, Re Cell                                          1 (3%)                                                          
      Pigmentation, Hemosiderin                        2 (4%)       1 (3%)       1 (2%)                                             
      Endothelium, Hyperplasia                         2 (4%)                    1 (2%)                                             
      Red Pulp, Atrophy                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (9)          (10)         (12)                                                
      Hyperplasia                                      1 (11%)                   1 (8%)                                             
      Hyperplasia, Cystic                              1 (11%)      1 (10%)                                                         
      Inflammation, Focal, Granulomatous                            1 (10%)                                                         
      Duct, Cyst                                                    1 (10%)                                                         
      Duct, Hemorrhage, Chronic                                     1 (10%)                                                         
   Skin                                               (20)         (26)         (28)                                                
      Cyst Epithelial Inclusion                        1 (5%)       1 (4%)                                                          
      Hyperkeratosis                                   1 (5%)                    1 (4%)                                             
      Head, Inflammation, Acute                                     1 (4%)                                                          
      Subcutaneous Tissue, Hemorrhage                  1 (5%)       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (20)         (50)                                                
      Lateral Ventricle, Hemorrhage                    1 (2%)                                                                       
      Pons, Hemorrhage                                              1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (50)                                                
      Adenomatosis                                                               1 (2%)                                             
      Congestion                                      12 (24%)     22 (73%)     16 (32%)                                            
      Hemorrhage                                                    1 (3%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Granulomatous                     11 (22%)      1 (3%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                                                       
      Alveolar Epithelium, Pigmentation                                          1 (2%)                                             
      Alveolus, Inflammation, Acute                                 1 (3%)                                                          
      Interstitium, Inflammation, Chronic              1 (2%)                                                                       
      Perivascular, Inflammation, Chronic                           1 (3%)       1 (2%)                                             
   Nose                                               (12)         (21)         (21)                                                
      Nasolacrimal Duct, Inflammation, Chronic         4 (33%)      4 (19%)      1 (5%)                                             
      Sinus, Inflammation, Chronic                                  2 (10%)                                                         
   Trachea                                            (50)         (19)         (50)                                                
      Mucosa, Pigmentation                                                       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (5)          (3)                                                 
      Cataract                                         2 (40%)                   1 (33%)                                            
      Anterior Chamber, Inflammation, Suppurative                                1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Congestion                                       4 (8%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
      Nephropathy                                     47 (94%)     46 (94%)     50 (100%)                                           
      Artery, Pelvis, Inflammation, Chronic                         1 (2%)                                                          
      Capsule, Developmental Malformation              1 (2%)                                                                       
      Renal Tubule, Hyperplasia, Focal                              2 (4%)       6 (12%)                                            
      Renal Tubule, Pigmentation, Hemosiderin          1 (2%)      27 (55%)     42 (84%)                                            
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Concretion                                                    1 (2%)       1 (2%)                                             
      Mucosa, Hyperplasia, Focal                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05043-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 17:45:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .0125 G/     .025G/KG                                               
                                                   72 VM        KG 72LM      72HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Wall, Inflammation, Suppurative                  1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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