National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1672

TDMS Study 05043-01 Pathology Tables

NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97
Route: GAVAGE                                                                                                     Time: 08:06:21




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +                             +              +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X                 X        X           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +        +  +   |             
      Hemangiosarcoma                      |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                 +     +  +        +                 +           +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  M  +     +  +  +  +  +  M  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Leukemia Mononuclear                 | X                                                                        |             
      Medulla, Osteosarcoma, Metastatic,   |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     M  +  +     +  +  +  +  M  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +     +  +  +  +     +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +     M  M  +  +  +  +  M  M     M  +     M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Pars Distalis, Adenoma               |    X                    X  X  X  X  X           X           X     X  X   |             
      Pars Distalis, Carcinoma             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                      +     +                    +        +  +           +|             
      Adenoma                              |                                                 X                        |             
      Adenoma, Moderate                    |                                                                          |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +     +  +  +  +  M  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Periovarian Tissue, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                      +                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                  X  X           X                 X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +  +  +  +  M  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X        X           X         |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +     +                             +              M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +     +  +  +  +  +  +           +        +  +     +  +  +|             
      Carcinoma                            |                      X                                                   |             
      Fibroadenoma                         | X              X        X     X     X                             X  X   |             
      Fibroadenoma, Multiple               |    X                             X              X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|             
                                           | 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +     +                             +     +  +     +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                X  X      |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +     +                             +              +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Cerebrum, Carcinoma, Deep Invasion,  |                                                                          |             
           Metastatic, Pituitary Gland     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Leukemia Mononuclear                 | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +     +                             +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                 +                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X                 X        X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  M  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                                            A     +         |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X        X        X           X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +                 +  +  +                 +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Medulla, Osteosarcoma, Metastatic,   |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Pheochromocytoma Benign              |                                              X        X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  M  +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Pars Distalis, Adenoma               |    X     X        X     X  X                    X     X        X  X      |             
      Pars Distalis, Carcinoma             |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                   X                                   X        X         |             
      C-Cell, Carcinoma                    |                                                 X                       X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                                            +     +         |             
      Adenoma                              |                                                                          |             
      Adenoma, Moderate                    |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Periovarian Tissue, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                                                  +         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Polyp Stromal                        | X                       X        X  X           X           X        X   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                            A     +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                              X                          X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X     X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X        X        X           X     X|             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                                            A     +         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                    +  +        +           +     +  +  +   |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |    X                             X  X        X                       X   |             
      Fibroadenoma, Multiple               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|             
                                           | 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                                            +  +  +         |             
      Subcutaneous Tissue, Fibroma         |                                                             X            |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                                            +     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Carcinoma, Deep Invasion,  |                                                                          |             
           Metastatic, Pituitary Gland     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                         X           X        X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                                            +     +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X        X        X           X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                 +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                 +                                                   |   9        |
      Adenocarcinoma                       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |       X              X                                                   |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                                   |   6        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +        +                                                   |  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +     +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +     +     +                                             |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +     +     +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +     +     +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Medulla, Osteosarcoma, Metastatic,   |                                                                          |            |
           Uncertain Primary Site          |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +        +     +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +     +     +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +     M  +     +     +                                             |  38        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X        X              X                                             |         22 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +     +     +                                             |  50        |
      C-Cell, Adenoma                      |    X  X                    X                                             |          7 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +                 +                                                   |  12        |
      Adenoma                              |                                                                          |          1 |
      Adenoma, Moderate                    |    X                                                                     |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +     +     +                                             |  49        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                X                                                         |          1 |
      Periovarian Tissue, Leukemia         |                                                                          |            |
          Mononuclear                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |       X                                                                  |         12 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                    +                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +     +     +                                             |  49        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +     M  M     +     +                                             |  44        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +     +     +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +     +     +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X              X                                                   |         12 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                    +                                                   |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                    +     +                                             |  27        |
      Carcinoma                            | X                          X                                             |          3 |
      Fibroadenoma                         |                                                                          |         12 |
      Fibroadenoma, Multiple               |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                    +                                                   |  12        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          3 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                    +                                                   |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +     +     +                                             |  50        |
      Cerebrum, Carcinoma, Deep Invasion,  |                                                                          |            |
           Metastatic, Pituitary Gland     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +     +     +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          6 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                    +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +     +     +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 4| 7| 7| 4| 2| 4| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3|                                            |            |
                                           | 9| 6| 6| 0| 6| 6| 2| 6| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +     +     +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +     +     +                                             |  50        |
      Leukemia Mononuclear                 |       X              X                                                   |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                             +           +  +              M|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +     +                 +  +  +     +     +  +  +  +     +  +     +|             
      Leukemia Mononuclear                 |                                     X           X                 X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                             +           +  +              +|             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                       +     +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                       +     +           +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                       +     +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                    +        +           +  +              +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +                             +           +  +              +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +                             +           +  +              +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                       +     +           +  +              +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X     X     X  X  X     X        X              X  X  X           X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                             +           +  +              +|             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +                       +     +           +  +              M|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +     +                       +           +  +              +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                           +           +  +              +|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +        +  +                 +        +           +  +              +|             
      Polyp Stromal                        |                X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             M                             +           M  +              M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +                       +     +     +  +  +  +        +     +|             
      Leukemia Mononuclear                 |                                     X           X                 X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                             +           +  M              +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           M     +  +        +  +  +     +        +  +  +  +  +  +     +|             
      Fibroadenoma                         |                   X  X        X     X              X        X  X  X     X|             
      Fibroadenoma, Multiple               | X                                X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +                          +           +  +              +|             
      Subcutaneous Tissue, Fibroma         |                X                                                         |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +           +  +              +|             
      Pons, Glioma NOS                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +                          +     +     +  +        +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|             
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +           +  +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                             +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                      +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pelvis, Leukemia Mononuclear         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Papilloma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                     X           X                 X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +     +                             +     A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +                             A     A               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +     +                             A     A  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +                             +     A               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +                             A     A               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +                             A     +               |             
                                            __________________________________________________________________________|             
   Liver                                   |                +     +              +        +  +  +     +           +   |             
      Leukemia Mononuclear                 |                X                                X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                                                              +   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +                             +     +               |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +                             +     +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +                          +  +     +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +                          +  +     +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +                          +  +     +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    +                             +     +               |             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      +                             +     M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pars Distalis, Adenoma               | X     X        X  X              X  X        X  X              X     X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +                             +     +               |             
      C-Cell, Carcinoma                    |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +           +  +                             +     M           +   |             
      Adenoma                              |       X                                                                  |             
      Carcinoma                            | X                                                                    X   |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +              +                             +     +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  |                      +                             +     +               |             
      Polyp Stromal                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +        +  +  +  +     +  +  +     +  M  +  +  +  +|             
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +                             +     +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +        +  +  +  +     +  +  +     +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +     +                          +  +     +           +   |             
      Leukemia Mononuclear                 |                X                                X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +                          +  +     +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +  M                 +     +     +     M     +  +      |             
      Fibroadenoma                         |    X  X                                X     X                 X  X      |             
      Fibroadenoma, Multiple               | X              X  X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +                             +     +               |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +                             +     +               |             
      Pons, Glioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +                             +     +               |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|             
                                           | 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .0125 G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +                             +     +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +                             +     +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +              +                 +  +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pelvis, Leukemia Mononuclear         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +        +  +  +                                             |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +        +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  30        |
      Leukemia Mononuclear                 |                      X  X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +  +  +                                             |  13        |
      Acinus, Adenoma                      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +        +  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +        +  +  +                                             |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +        +  +  +                                             |  13        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +        +  +  +                                             |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +        +  +  +                                             |  15        |
      Leukemia Mononuclear                 |                      X  X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +        +  +  +                                             |  15        |
      Leukemia Mononuclear                 |                      X  X                                                |          3 |
      Pheochromocytoma Benign              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +        +  +  +                                             |  14        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +        +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Pars Distalis, Adenoma               | X        X        X     X                                                |         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +        +  +  +                                             |  12        |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +  M  +     +  +  +                                             |  17        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +        +  +  +                                             |  15        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |             +              +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +        +  +  +                                             |  15        |
      Polyp Stromal                        |                      X                                                   |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +        +  +  +                                             |  10        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +  +     +  +  +                                             |  20        |
      Leukemia Mononuclear                 |                      X  X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M        +  +  +                                             |  11        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +        +  +  +                                             |  29        |
      Fibroadenoma                         |                            X                                             |         16 |
      Fibroadenoma, Multiple               |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +        +  +  +                                             |  13        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +        +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +        +  M  +                                             |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9|                                            |            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    .0125 G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pons, Glioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +     +        +  +  +                                             |  17        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X  X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +        +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +        +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Pelvis, Leukemia Mononuclear         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X  X                                                |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +           +        +                 +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +        +                                +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +        +                 +              +     +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +           +        +                                +     +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X  X     X                             X     X           X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +              +                                                |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +        +     +  +  +  +  +  +        +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X                                      X     X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                   X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  M     +  M  M  +  +  +  +  M  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               | X              X     X           X  X  X  X              X  X  X  X      |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bilateral, C-Cell, Adenoma           |    X                                                                     |             
      C-Cell, Adenoma                      |                                              X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                         +                    +                    +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                                                                   X      |             
      Periovarian Tissue, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |       X           X                             X           X           X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +                                         +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pancreatic, Leukemia Mononuclear     |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X  X     X                             X     X           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  +           +                                         +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +     +           +  +  +     +  +              +     +|             
      Fibroadenoma                         |                X                    X  X  X     X  X                     |             
      Fibroadenoma, Multiple               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +                    +                    +     +|             
      Basal Cell Adenoma                   |                                              X                           |             
      Sebaceous Gland, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +                                         +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Abdominal, Sarcoma                   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|             
                                           | 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma, Metastatic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X  X     X                             X     X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +                                         M     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X  X     X                             X     X           X      |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           +                              |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           M                              |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                  M        +                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                               X                 X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +              +        +     +     +                       +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +     +  +  M  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +     +  +  +  M        +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  M     +  +  +     M  +  M  M        +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X           X  X  X        X  X           X  X           X     X      |             
      Pars Distalis, Carcinoma             |       X                             X              X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      | X              X  X              X                                       |             
      C-Cell, Carcinoma                    |    X                                                                 X  X|             
      Follicular Cell, Adenoma             |                X        X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           +  +                       +   |             
      Adenoma                              |                                              X                           |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Periovarian Tissue, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X                 X                             X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +           +  +  +     M  +  +     +  +  +  +        +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                               X                 X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                           +                              |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +  +                 M                 +  +         |             
      Fibroadenoma                         |                      X  X                                   X            |             
      Fibroadenoma, Multiple               |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    |                                     +     +                              |             
      Basal Cell Adenoma                   |                                                                          |             
      Sebaceous Gland, Adenoma             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                           +                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Sarcoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|             
                                           | 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .025G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Carcinoma, Metastatic                |       X                             X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           +                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +     +  +  +     +  +  +  +        +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                               X                 X      |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +  +                                                |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      +  +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                      +  +                                                |   9        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      +  +                                                |   7        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X           X                                                   |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +                                                   |   4        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +        +  +  +  +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  48        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Pheochromocytoma Benign              |    X     X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  M                                                |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Pars Distalis, Adenoma               |    X  X        X        X                                                |         25 |
      Pars Distalis, Carcinoma             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          6 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      +  +                                                |   9        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +                                                |  49        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Periovarian Tissue, Leukemia         |                                                                          |            |
          Mononuclear                      |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                      +  +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Polyp Stromal                        |                   X                                                      |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                      +  +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +     +  +  +  +                                                |  46        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X           X                                                   |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      +  +                                                |   8        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +           +     +  +                                                |  19        |
      Fibroadenoma                         |    X           X                                                         |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5|                                            |            |
                                           | 1| 1| 1| 3| 0| 1| 1| 6| 8| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    .025G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     72HF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma, Multiple               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +  +                                                |   9        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                      +  +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Sarcoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Carcinoma, Metastatic                |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X           X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                      +  +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X           X                                                   |         11 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +  +                                +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                 +  +                                +        +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +  +                                M        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                 +  +                                +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  A  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +                 +  +                                +        +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                 +  +                                +        +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                 X        X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +           +     +                 +        +         |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Mesothelioma Malignant               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Acinus, Adenoma                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +           +  +        +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Extra Adrenal Tissue, Leukemia       |                                                                          |             
          Mononuclear                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                X                 X     X              X                  |             
      Pheochromocytoma Benign              |                   X                    X                                 |             
      Bilateral, Pheochromocytoma Benign   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                  X                     |             
      Carcinoma                            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X        X     X     X           X  X     X  X     X  X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Carcinoma         |                                                                          |             
      C-Cell, Adenoma                      |       X                             X                                    |             
      C-Cell, Carcinoma                    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Malignant       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +     +  +           +                    +        +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X           X  X     X        X     X     X  X         |             
      Interstitial Cell, Adenoma           |                      X              X        X     X                 X   |             
      Tunic, Mesothelioma Malignant        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                 +  +                                M        +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                 X                                    |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Poorly Differentiated       |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +                 +  +                                +        +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|             
                                           | 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M                 M  +                             +  +     +  M  M  M|             
      Fibroadenoma                         | X                                                     X        X         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                 +  +     +        +           +     +        +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                        X                                 |             
      Squamous Cell Carcinoma              |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                    X                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                 +  +                                +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +  +                                +        +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                            +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                               +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Serosa, Mesothelioma Malignant       |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                 X        X                           |             
      Mesothelioma Malignant               |                   X                    X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             A              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             A              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                           A              +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                           A              +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             A              +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                           A              +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                    X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +        +     +  +  +  +     +  +  +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +        +  +  +  +  A  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Extra Adrenal Tissue, Leukemia       |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pheochromocytoma Malignant           |                                  X                             X         |             
      Pheochromocytoma Benign              |             X     X           X                             X            |             
      Bilateral, Pheochromocytoma Benign   |                                              X                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Adenoma               |    X     X           X        X  X                    X  X        X      |             
      Pars Distalis, Carcinoma             |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Bilateral, C-Cell, Carcinoma         |                   X                                                      |             
      C-Cell, Adenoma                      |                               X  X                                       |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           A     +                    +              +               |             
      Adenoma                              |    X                                                                     |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Adenoma                              |                   X                          X                           |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X     X           X  X  X  X        X  X  X        X         |             
      Interstitial Cell, Adenoma           |                X     X                    X  X           X  X            |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                           +              +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                    X               |             
      Sarcoma                              |                                                 X                        |             
      Sarcoma, Poorly Differentiated       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +              +  +  +              +     +         |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|             
                                           | 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           +              M  +            |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |          +                       +        +        +     +  +  +         |             
      Basal Cell Adenoma                   |                                                                X         |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                             X            |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                           +              +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |       X                                      X                           |             
      Leukemia Mononuclear                 |                                     X                    X               |             
                                            __________________________________________________________________________|             
   Nose                                    |                                           A              +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Renal Tubule, Carcinoma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                    X               |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +                                                               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +                                                               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +     +  +  +  +                                                |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +                                                               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +                                                               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   7        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +        +                                                      |  40        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      Extra Adrenal Tissue, Leukemia       |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Pheochromocytoma Malignant           |       X                                                                  |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |    X                    X                                                |          8 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
      Adenoma                              |    X                                                                     |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +                                                |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Pars Distalis, Adenoma               |          X     X  X  X                                                   |         23 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      Bilateral, C-Cell, Carcinoma         |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +                                                               |  17        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X     X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  49        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Bilateral, Interstitial Cell, Adenoma|    X                                                                     |         25 |
      Interstitial Cell, Adenoma           | X        X     X  X  X  X                                                |         17 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  11        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          6 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Poorly Differentiated       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +              +                                                |  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +     +                                                         |   9        |
      Fibroadenoma                         |                X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +                                                               |  20        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |          X                                                               |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Sebaceous Gland, Carcinoma           |    X                                                                     |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 |          X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 4| 7| 7| 6| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5|                                            |            |
                                           | 1| 0| 5| 2| 4| 6| 7| 6| 9| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
    72 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +        +  +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +        +  +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +           +  +  +  +        +     +        +      |             
      Leukemia Mononuclear                 |                      X           X        X                              |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +        +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +              +  +  +        +     +     +         |             
      Acinus, Adenoma, Multiple            |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                X                 X                                X      |             
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +                 +  +  +        +     +               |             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M           M                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Pars Distalis, Adenoma               |    X                 X        X     X  X  X                       X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +                 +  +  +        +     +               |             
      C-Cell, Adenoma                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +                 +  +  +  +  +  +     +               |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +           +                 +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +           +     +           +  +  +        +     +               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Bilateral, Interstitial Cell, Adenoma|                X        X     X              X  X           X  X  X  X   |             
      Interstitial Cell, Adenoma           |    X  X              X           X  X              X                     |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +                 +  +  +        +     +               |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X                              |             
      Mediastinal, Leukemia Mononuclear    |                                           X                              |             
      Pancreatic, Leukemia Mononuclear     |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +     +           +  +  +        M     M               |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +  +  +  M  +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +        +  +  +  +  +  +  +     +               |             
      Hemangiosarcoma                      |                      X                                                   |             
      Leukemia Mononuclear                 |                      X           X        X                              |             
      Sarcoma                              |                         X                       X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           +                 +  +  M        +     +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +  +           +     M  M  M        M     +               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +           +                 +  +  +        +     +        +      |             
      Basal Cell Adenoma                   |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +                 +  +  +        +     +               |             
      Glioma NOS                           |                                                                          |             
      Squamous Cell Carcinoma, Early       |                                                                          |             
          Invasion, Metastatic, Zymbal's   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|             
                                           | 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +           +                 +  +  +     +  +     +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +           +                 +  +  +        +     +               |             
      Nares, Squamous Cell Papilloma       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +                 +  +  +        +     +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                      X           X        X                              |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +                             M        +        +     +     M|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +                             +        +        +     +     A|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +     +  +     +  +        +        +     +     A|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Serosa, Mesothelioma Malignant       |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +     +     +                                          |             
      Mesothelioma Malignant               |                   X     X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +                    +        +        +        +     +     M|             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +                             +        +        +     +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +                             +        +        +     +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Pheochromocytoma Malignant           |                               X              X                           |             
      Pheochromocytoma Benign              |                      X        X                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +                    +        +        +        +     +     M|             
      Adenoma                              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M  M                             M        +        +     +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Pars Distalis, Adenoma               |                   X  X                             X        X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +                 +           +        +        +     +     A|             
      C-Cell, Adenoma                      |                               X                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +           +                 +        +        +     +     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Serosa, Mesothelioma Malignant       |                         X                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +           +                 +        +        +     +     +|             
      Adenoma                              |       X                 X                                                |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +                             +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +  +  +     +                 +  +        +        +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X  X     X     X        X     X  X           X     X      |             
      Interstitial Cell, Adenoma           |          X           X           X  X     X                              |             
      Tunic, Mesothelioma Malignant        |                   X     X                                         X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +                             +        +        +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       M  +  M                             +        +        +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +                 +        +  +     +  +        +     +     +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                        X                                 |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +                             +        +        +     +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M                             M        +                    M|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +                 +     +        +        +     +     +|             
      Basal Cell Adenoma                   |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                     X                                    |             
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +                             +        +              +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +                             +        +        +     +     +|             
      Glioma NOS                           |                                                                   X      |             
      Squamous Cell Carcinoma, Early       |                                                                          |             
          Invasion, Metastatic, Zymbal's   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|             
                             DAY ON TEST   | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|             
                                           | 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .0125 G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +                    +  +  +  +  +  +  +        +     +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +           +                 +        +        +     +     +|             
      Nares, Squamous Cell Papilloma       |                         X                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +                             +        +        +     +     A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +           +        +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Carcinoma                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     A|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  A  +        +     +     +|             
      Serosa, Mesothelioma Malignant       |                         X                                                |             
      Transitional Epithelium, Carcinoma   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +     +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                   X     X                                         X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +           +  +                                             |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +           +  A                                             |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +           +  +                                             |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +           +  A                                             |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  +           +  +                                             |  31        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +                                             |   8        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +           +  +                                             |  22        |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +           +  +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +           +  +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +           +  +                                             |  23        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +  +                                             |  22        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              | X                 X                                                      |          7 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +           +  +                                             |  22        |
      Adenoma                              |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +           +  M                                             |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               | X  X  X  X     X  X                                                      |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +           +  +                                             |  20        |
      C-Cell, Adenoma                      |          X                                                               |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +           +  +                                             |  20        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  +           +  +                                             |  24        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                |          M  +           +  +                                             |  19        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Bilateral, Interstitial Cell, Adenoma| X        X     X     X                                                   |         25 |
      Interstitial Cell, Adenoma           |    X  X     X     X     X  X                                             |         17 |
      Tunic, Mesothelioma Malignant        |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +           +  +                                             |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          M  M           M  +                                             |  14        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +           +  +                                             |  29        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Sarcoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  M           M  +                                             |  17        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  M           M  M                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +        +  +  +                                             |  26        |
      Basal Cell Adenoma                   | X                                                                        |          1 |
      Squamous Cell Papilloma              |                      X                                                   |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +           +  +                                             |  19        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 4| 7| 7| 7| 6| 5|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0|                                            |            |
                                           | 3| 8| 3| 8| 0| 3| 3| 3| 4| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .0125 G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +  +                                             |  20        |
      Glioma NOS                           |                                                                          |          1 |
      Squamous Cell Carcinoma, Early       |                                                                          |            |
          Invasion, Metastatic, Zymbal's   |                                                                          |            |
          Gland                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +  +        +  +                                             |  30        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +           +  +                                             |  21        |
      Nares, Squamous Cell Papilloma       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +           +  +                                             |  19        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +                             M        +  +           +  +   |             
      Serosa, Sarcoma, Metastatic          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +                             +        +  +     +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +                             +        +  +           +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X        X           X         |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +           +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +     +     +           +  +  +  +  +  +  +     +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Squamous Cell Papilloma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X                              |             
      Pheochromocytoma Malignant           |                                                 X                        |             
      Pheochromocytoma Benign              |                      X              X           X           X        X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  M     +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  M  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X     X                 X              X     X  X     X     X  X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      C-Cell, Adenoma                      |                                                             X            |             
      C-Cell, Adenoma, Mild                |                                                                          |             
      C-Cell, Carcinoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Serosa, Sarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +                          +  +     +  +  +           +  +   |             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                        X           X                     |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Bilateral, Interstitial Cell, Adenoma| X  X        X     X  X  X        X  X  X     X  X  X        X     X      |             
      Interstitial Cell, Adenoma           |       X  X                                X                    X     X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +                             +        +  +           +  +   |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +     +        +  +  +  +  +  +  +  M     +  +  M  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X        X           X         |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +                    +        M  +           +  +   |             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M                             +        +  M           +  +   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +                 +  +     +  +           +  +   |             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                         X                    X                           |             
      Keratoacanthoma, Multiple            |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                       X                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Metastatic, Uncertain Primary    |                                                                          |             
          Site                             |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +                             +           +           +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Sarcoma                   |                                                                          |             
      Hindlimb, Sarcoma, Metastatic,       |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Astrocytoma Malignant                |                                                                X         |             
      Granular Cell Tumor Benign           |                                                             X            |             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebellum, Leukemia Mononuclear     |                                                    X                     |             
      Cerebrum, Leukemia Mononuclear       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                      X                       X     X                     |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                                           X        X           X         |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|             
                                           | 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +                             +        M  +           +  +   |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                          M                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic                  |                                                                          |             
      Renal Tubule, Adenoma                |                                     X                                    |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X        X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +        +        +           +  +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +        +        +           +  +     +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +        +        +           +  +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +        +        +           +  +     +  +  +  +               |             
      Serosa, Sarcoma, Metastatic          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +        +        +              A        +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +        +        +              +        +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Acinus, Adenoma                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +  +     +  +           +  +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                         X                    X                           |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     M  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X     X                       X                    X      |             
      Pars Distalis, Carcinoma             |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      C-Cell, Adenoma                      |                   X                                                      |             
      C-Cell, Adenoma, Mild                |       X                                                                  |             
      C-Cell, Carcinoma                    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Serosa, Sarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +     +           +  +     +  +  +  +        +      |             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X  X  X  X  X  X  X  X  X     X  X        X  X         |             
      Interstitial Cell, Adenoma           |    X     X                                   X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +        +        +           +  M     +  +  +  +               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Mediastinal, Leukemia Mononuclear    |       X                                                                  |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Sarcoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +        +     +  +           +  +     +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +        +        M           M  M     M  M  M  +        +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +        +        +           +  +  +  +  +  +  +  +            |             
      Basal Cell Adenoma                   | X                                                                        |             
      Keratoacanthoma                      |                                        X                                 |             
      Keratoacanthoma, Multiple            |                                              X                           |             
      Squamous Cell Carcinoma              | X                                                                        |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         | X                                                                        |             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                                                     |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Metastatic, Uncertain Primary    |                                                                          |             
          Site                             |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +        +        +           +  +     +  +  +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Abdominal, Sarcoma                   |                                                          X               |             
      Hindlimb, Sarcoma, Metastatic,       |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Astrocytoma Malignant                |                                                                          |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Cerebellum, Leukemia Mononuclear     |                                                                          |             
      Cerebrum, Leukemia Mononuclear       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|    X                                                                     |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|             
                             DAY ON TEST   | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|             
                                           | 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .025G/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +        +        +           +  +     +  +  +  +               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Sarcoma, Metastatic                  |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +  +  +  +                                                |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     +  +  +  +                                                |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +                                                |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +  +  +  +                                                |  21        |
      Serosa, Sarcoma, Metastatic          |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
      Acinus, Adenoma                      | X  X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +     +  +  +  +                                                |  37        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Pheochromocytoma Malignant           |                                                                          |          3 |
      Pheochromocytoma Benign              | X                                                                        |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Pars Distalis, Adenoma               |                X                                                         |         14 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Adenoma, Mild                |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
      Serosa, Sarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +  +  +  +                                                |  26        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X                                                         |         35 |
      Interstitial Cell, Adenoma           |                   X  X  X                                                |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     +  +  +  +                                                |  21        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |       X                                                                  |          2 |
      Pancreatic, Leukemia Mononuclear     |       X                                                                  |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +                                                |  47        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +     +  +  +  +                                                |  24        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  +  M  +                                                |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +  +  +  +                                                |  28        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          3 |
      Keratoacanthoma, Multiple            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Metastatic, Uncertain Primary    |                                                                          |            |
          Site                             |          X                                                               |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +                                                |  20        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
      Abdominal, Sarcoma                   |                                                                          |          1 |
      Hindlimb, Sarcoma, Metastatic,       |                                                                          |            |
          Uncertain Primary Site           |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05043-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:06:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 4| 5| 5| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5|                                            |            |
                                           | 4| 4| 5| 5| 6| 2| 6| 2| 2| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    .025G/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
    72HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Cerebellum, Leukemia Mononuclear     |                                                                          |          1 |
      Cerebrum, Leukemia Mononuclear       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +  +  +  +                                                |  21        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Sarcoma, Metastatic                  |          X                                                               |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
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