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TDMS Study 05044-02 Pathology Tables

NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X        X                                                |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                        X  X     X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +        +              +                 +            |             
      Hemangioma                           |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                             X            |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                             X            |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              | X                          X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                  X                                       |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X                       X  X  X  X     X        X        X     X   |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Osteosarcoma, Metastatic, Metastatic |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Luteoma                              |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |                   X                                               X      |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                           X                              |             
      Mast Cell Tumor NOS                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                   X                                               X      |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             | X                                      X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +     +                 +                                    |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                  X        X                              |             
      Hemangiosarcoma, Metastatic          |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                   X                                               X      |             
      Lymphoma Malignant Mixed             | X                                X     X  X     X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |       X              X                                      X            |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Abdominal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X     X                                                                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|             
                                           | 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             | X                                      X                                 |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |       X                                                     X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X              X                 X           X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                               X      |             
      Lymphoma Malignant Mixed             |                                        X        X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                             X            |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X        X                                               X      |             
      Lymphoma Malignant Mixed             | X                                X     X  X     X           X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |       X              X              X                       X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                          X        X      |             
      Hepatocellular Adenoma               |          X  X                    X                 X                    X|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |             X                                                            |             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X     X                    X        X        X  X        X         |             
      Pars Intermedia, Adenoma             |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Osteosarcoma, Metastatic, Metastatic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                         +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |             X                                                            |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Polyp Stromal                        |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Mast Cell Tumor NOS                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                       +                    +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma, Metastatic          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |             X     X              X                                   X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X                                                                  |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |    X                                                                     |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|             
                                           | 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +|             
      Adenoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |             X     X              X                                   X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |          7 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Squamous Cell Papilloma              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Adenoma                     |                                                                          |          2 |
      Capsule, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Adenoma               |                                                                          |         17 |
      Pars Intermedia, Adenoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Osteosarcoma, Metastatic, Metastatic |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Cystadenoma                          |                                                                          |          1 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Mast Cell Tumor NOS                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   6        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hemangioma                           |                                                                          |          2 |
      Hemangiosarcoma, Metastatic          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          9 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          3 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  44        |
      Adenocarcinoma                       |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  43        |
      Adenoma                              |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 8| 9| 9| 8| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |         10 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                                            X   |             
      Hepatocellular Adenoma               |       X        X     X        X                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Histiocytic       |                                                                          |             
          Sarcoma, Metastatic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                     X                                    |             
      Extra Adrenal Tissue, Histiocytic    |                                                                          |             
          Sarcoma, Metastatic              |                                                             X            |             
      Extra Adrenal Tissue, Lymphoma       |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X           X     X     X                       X              X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Bilateral, Histiocytic Sarcoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Bilateral, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangiosarcoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Histiocytic Sarcoma,         |                                                                          |             
          Metastatic                       |                                                             X            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                    +           +         |             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Mixed             |                X                       X                                 |             
      Capsule, Histiocytic Sarcoma,        |                                                                          |             
          Metastatic                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Back, Lymphoma Malignant Lymphocytic |                                                                          |             
      Back, Squamous Cell Carcinoma        |                                                                         X|             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Scapula, Squamous Cell Carcinoma     |       X                                X                       X         |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                                                                         X|             
      Sebaceous Gland, Adenocarcinoma      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                        X                          X  X   |             
      Alveolar/Bronchiolar Carcinoma       |             X                    X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Metastatic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|             
                                           | 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                X                       X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Sarcoma, Metastatic                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Hepatocellular Adenoma               |                         X              X                                 |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +        +      |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
      Peridontal Tissue, Histiocytic       |                                                                          |             
          Sarcoma, Metastatic              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Capsule, Adenoma                     |                                                                          |             
      Extra Adrenal Tissue, Histiocytic    |                                                                          |             
          Sarcoma, Metastatic              |                                                                          |             
      Extra Adrenal Tissue, Lymphoma       |                                                                          |             
          Malignant Lymphocytic            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Adenoma               |    X  X     X  X  X  X  X  X  X                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X               |             
      Bilateral, Histiocytic Sarcoma,      |                                                                          |             
          Metastatic                       |                                     X                                    |             
      Bilateral, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |             
      Histiocytic Sarcoma                  |                                     X                                    |             
      Polyp Stromal                        |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Femoral, Hemangiosarcoma             |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lumbar, Histiocytic Sarcoma,         |                                                                          |             
          Metastatic                       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                          X               |             
      Pancreatic, Lymphoma Malignant Mixed |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                          X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                    |             
      Histiocytic Sarcoma, Metastatic      |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hemangiosarcoma                      |          X                                                               |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Capsule, Histiocytic Sarcoma,        |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  M      |             
      Adenocarcinoma                       |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Back, Lymphoma Malignant Lymphocytic |                                                                   X      |             
      Back, Squamous Cell Carcinoma        |                                                                          |             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Scapula, Squamous Cell Carcinoma     |                X                          X                              |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                                                                          |             
      Sebaceous Gland, Adenocarcinoma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                X         |             
      Alveolar/Bronchiolar Adenoma         |                         X  X                                             |             
      Alveolar/Bronchiolar Carcinoma       |             X        X                                                   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Metastatic                      |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|             
                                           | 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                          X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Histiocytic Sarcoma, Metastatic      |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Histiocytic Sarcoma                  |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +                    +                                             |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                    +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                    +                                             |  50        |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +                    +                                             |  50        |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               |                                                                          |          6 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                    +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                    +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Histiocytic       |                                                                          |            |
          Sarcoma, Metastatic              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                    +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                    +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Adenoma                     |                                                                          |          1 |
      Extra Adrenal Tissue, Histiocytic    |                                                                          |            |
          Sarcoma, Metastatic              |                                                                          |          1 |
      Extra Adrenal Tissue, Lymphoma       |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                    +                                             |  49        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                    +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M                    M                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +                    M                                             |  48        |
      Pars Distalis, Adenoma               |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +                    +                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                    +                                             |  49        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Bilateral, Histiocytic Sarcoma,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Bilateral, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +                    +                                             |  49        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                    +                                             |  50        |
      Femoral, Hemangiosarcoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                    I                                             |  49        |
      Lumbar, Histiocytic Sarcoma,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                    I                                             |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   4        |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +                    +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Capsule, Histiocytic Sarcoma,        |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                    M                                             |  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +                    M                                             |  41        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                    +                                             |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Back, Lymphoma Malignant Lymphocytic |                                                                          |          1 |
      Back, Squamous Cell Carcinoma        |                                                                          |          1 |
      Scapula, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Scapula, Squamous Cell Carcinoma     |                                                                          |          5 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Sebaceous Gland, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                    +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                    +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +                    +                                             |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                    +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                    +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       M                    +                                             |  46        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                    +                                             |  50        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                    +                                             |  49        |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +                    +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2|                                            |            |
                                           | 8| 9| 1| 8| 9| 8| 8| 8| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Sarcoma, Metastatic                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                   X      |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |          X                                X                             X|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic, Metastatic          |                                                                          |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                +               |             
      Sarcoma, Metastatic                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Adenoma          |                                                                          |             
      Capsule, Adenoma                     |                X                             X                          X|             
      Extra Adrenal Tissue, Histiocytic    |                                                                          |             
          Sarcoma, Metastatic              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Granulocytic                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                   X  X  X                                                |             
      Pars Distalis, Carcinoma             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                  X                                       |             
      Granulosa Cell Tumor Benign          |    X                                            X  X                     |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Mixed Tumor Benign                   |    X        X                 X                                          |             
      Bilateral, Lymphoma Malignant        |                                                                          |             
          Histiocytic                      |                                                                          |             
      Bilateral, Lymphoma Malignant Mixed  |                                                                         X|             
      Bilateral, Mixed Tumor Benign        |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Metastatic                      |                            X                                             |             
      Axillary, Adenocarcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Mammary Gland                   |                                                                      X   |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                         X                                                |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                         X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                         X                                                |             
      Mediastinal, Lymphoma Malignant Mixed|                               X                                         X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                         X                                                |             
      Renal, Lymphoma Malignant Histiocytic|                         X                                                |             
      Renal, Lymphoma Malignant Mixed      |                               X                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                         X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |       X        X                 X  X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                    +  +  +                                         +|             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                         X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Capsule, Fibrous Histiocytoma        |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  M  +  +  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  +  M  M|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|             
      Adenocarcinoma                       |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                X           X        X                                    |             
      Back, Fibrous Histiocytoma           |                                                          X               |             
      Back, Osteosarcoma, Metastatic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Back, Squamous Cell Carcinoma        |                            X        X                 X                  |             
      Back, Squamous Cell Carcinoma,       |                                                                          |             
          Multiple                         |                                                                          |             
      Scapula, Basosquamous Tumor Malignant|                                                                          |             
      Scapula, Fibrous Histiocytoma        |                                                          X               |             
      Scapula, Squamous Cell Carcinoma     | X     X  X                       X  X              X              X      |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |    X        X  X  X  X     X  X           X     X     X                 X|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Scapula,        |                                                                          |             
          Squamous Cell Carcinoma,         |                                                                          |             
          Metastatic                       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                             +               |             
      Back, Sarcoma, Metastatic            |                                                          X               |             
      Intercostal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                      X   |             
      Alveolar/Bronchiolar Adenoma         |                                           X              X           X   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |             X                                                            |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                  X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Skin                            |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                         X|             
      Sarcoma, Metastatic                  |                                                          X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |       X                    X        X              X              X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|             
                             DAY ON TEST   | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|             
                                           | 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                  X                          X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                         X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
      Lymphoma Malignant Mixed             |                               X                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                   X                                                      |             
      Hepatocellular Carcinoma             |       X        X                                               X         |             
      Hepatocellular Adenoma               |    X        X                                                            |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic, Metastatic          |                                  X                                       |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                  X                                       |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +                                   +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                  X                                       |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Adenoma          |                                           X                              |             
      Capsule, Adenoma                     |    X                       X                             X               |             
      Extra Adrenal Tissue, Histiocytic    |                                                                          |             
          Sarcoma, Metastatic              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Granulocytic                |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                 X                        |             
      Pheochromocytoma Benign              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                     X                             X      |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                      X                                                   |             
      Granulosa Cell Tumor Benign          |                                                             X     X      |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                  X                                       |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mixed Tumor Benign                   |             X     X        X        X                 X              X   |             
      Bilateral, Lymphoma Malignant        |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Bilateral, Lymphoma Malignant Mixed  |                                                                          |             
      Bilateral, Mixed Tumor Benign        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |                                                                   X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Metastatic                      |                                                                          |             
      Axillary, Adenocarcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Mammary Gland                   |                                                                          |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |          X                                                               |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                    X                     |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                               X                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Renal, Lymphoma Malignant Histiocytic| X                                                                        |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic      |                                  X                                       |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                         +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                    X                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                               X                                          |             
      Capsule, Fibrous Histiocytoma        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Thymoma Benign                       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +|             
      Adenocarcinoma                       |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Back, Fibrous Histiocytoma           |                                                                          |             
      Back, Osteosarcoma, Metastatic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Back, Squamous Cell Carcinoma        |                                                                          |             
      Back, Squamous Cell Carcinoma,       |                                                                          |             
          Multiple                         |                                                                X         |             
      Scapula, Basosquamous Tumor Malignant|                                                    X                     |             
      Scapula, Fibrous Histiocytoma        |                                                                          |             
      Scapula, Squamous Cell Carcinoma     |             X     X        X  X                 X     X                 X|             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |    X  X  X     X     X                 X  X  X           X  X  X  X      |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                             |             
      Subcutaneous Tissue, Scapula,        |                                                                          |             
          Squamous Cell Carcinoma,         |                                                                          |             
          Metastatic                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Back, Sarcoma, Metastatic            |                                                                          |             
      Intercostal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |    X                                               X     X  X           X|             
      Alveolar/Bronchiolar Carcinoma       |             X                             X                          X   |             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Skin                            |                                                                X         |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Metastatic                      |                                  X                                       |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic                  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                X     X        X                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|             
                                           | 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  I  +  +  I  M  +|             
      Adenoma                              |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Leukemia Granulocytic                |             X                                                            |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic, Metastatic          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Bilateral, Capsule, Adenoma          |                                                                          |          1 |
      Capsule, Adenoma                     |                                                                          |          6 |
      Extra Adrenal Tissue, Histiocytic    |                                                                          |            |
          Sarcoma, Metastatic              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Leukemia Granulocytic                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Adenoma               |                                                                          |          5 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Granulosa Cell Tumor Malignant       |                                                                          |          2 |
      Granulosa Cell Tumor Benign          |                                                                          |          5 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mixed Tumor Benign                   |                                                                          |          9 |
      Bilateral, Lymphoma Malignant        |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Bilateral, Lymphoma Malignant Mixed  |                                                                          |          1 |
      Bilateral, Mixed Tumor Benign        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  47        |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Axillary, Adenocarcinoma, Metastatic,|                                                                          |            |
           Mammary Gland                   |                                                                          |          1 |
      Axillary, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                                                          |          2 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          2 |
      Renal, Lymphoma Malignant Histiocytic|                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  47        |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   6        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Capsule, Fibrous Histiocytoma        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  33        |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  41        |
      Adenocarcinoma                       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Squamous Cell Carcinoma              |                                                                          |          3 |
      Back, Fibrous Histiocytoma           |                                                                          |          1 |
      Back, Osteosarcoma, Metastatic       |                                                                          |          1 |
      Back, Squamous Cell Carcinoma        |                                                                          |          3 |
      Back, Squamous Cell Carcinoma,       |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Scapula, Basosquamous Tumor Malignant|                                                                          |          1 |
      Scapula, Fibrous Histiocytoma        |                                                                          |          1 |
      Scapula, Squamous Cell Carcinoma     |                                                                          |         14 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |         23 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Scapula,        |                                                                          |            |
          Squamous Cell Carcinoma,         |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  49        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Back, Sarcoma, Metastatic            |                                                                          |          1 |
      Intercostal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          8 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Granulosa Cell Tumor Malignant,      |                                                                          |            |
          Metastatic, Ovary                |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Skin                            |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Sarcoma, Metastatic                  |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  42        |
      Adenoma                              |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Granulocytic                |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                X         |             
      Hepatocellular Carcinoma             |                         X                                                |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic                      |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Papilloma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +        +                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X  X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                X                                                         |             
      Capsule, Carcinoma                   |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Granular Cell Tumor   |                                                                          |             
          Malignant, Metastatic            |                            X                                             |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                            X                             X               |             
      Granulosa Cell Tumor Benign          |    X                                         X                 X  X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Mixed Tumor Benign                   |       X                 X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |                   X                                                      |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |    X                                                  X     X            |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Deep Cervical, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Skin      |             X                                                            |             
      Lumbar, Squamous Cell Carcinoma,     |                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                                   +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M|             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma              |                                        X                                 |             
      Squamous Cell Carcinoma, Multiple    |                            X                                             |             
      Back, Lymphoma Malignant Lymphocytic |                                                                          |             
      Scapula, Basosquamous Tumor Malignant|                                                 X                        |             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Scapula, Squamous Cell Carcinoma     | X        X  X  X     X  X     X  X  X                 X  X  X  X        X|             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |    X  X                                      X                       X   |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple, Metastatic            |                      X                                      X            |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic                      |                                        X                 X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Intercostal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |          X                                                               |             
      Neck, Lymphoma Malignant Lymphocytic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|             
                             DAY ON TEST   | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|             
                                           | 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                        X                                 |             
      Alveolar/Bronchiolar Adenoma         |                                                          X  X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                            X                             X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                         X                                                |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |    X  X  X  X  X                    X        X                           |             
      Bronchiole, Adenocarcinoma,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X        X  X        X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma              |          X                                                               |             
      Squamous Cell Carcinoma, Metastatic  |          X                                                               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                                          X               |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic                      |                                                       X                  |             
      Hepatocellular Adenoma               |                                  X                                   X   |             
      Hepatocellular Adenoma, Multiple     |                                                       X                  |             
      Squamous Cell Carcinoma, Metastatic  |                                  X  X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Papilloma              |    X                                                  X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Carcinoma, Metastatic  |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     | X                                                                    X   |             
      Capsule, Carcinoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Granular Cell Tumor   |                                                                          |             
          Malignant, Metastatic            |                                                                          |             
      Pars Intermedia, Adenoma             |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Granulosa Cell Tumor Benign          |                   X  X     X        X                 X           X      |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Mixed Tumor Benign                   |          X                       X        X                          X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Polyp Stromal                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic  |             X                                                            |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |    X                                                                     |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Renal, Lymphoma Malignant Lymphocytic|                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                             X            |             
      Deep Cervical, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Skin      |                                                                          |             
      Lumbar, Squamous Cell Carcinoma,     |                                                                          |             
           Metastatic, Skin                |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +                 +           +  +                                 |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  M  M  +|             
      Squamous Cell Carcinoma, Metastatic  |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  I  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |          X     X                                         X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Back, Lymphoma Malignant Lymphocytic |                         X                                                |             
      Scapula, Basosquamous Tumor Malignant|                                                                          |             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Scapula, Squamous Cell Carcinoma     | X  X  X  X  X  X  X  X  X  X     X  X        X  X           X  X     X   |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                                        X  X           X  X        X     X|             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple, Metastatic            |                                                                          |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Intercostal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Neck, Lymphoma Malignant Lymphocytic |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|             
                                           | 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                            X                          X           X  X   |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Carcinoma, Metastatic  |                   X                                                      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X  X        X              X     X  X           X        X  X  X  X      |             
      Bronchiole, Adenocarcinoma,          |                                                                          |             
          Metastatic                       |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Adenoma                              |                X        X           X                                    |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                            X        X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Adenoma                     |                                                                          |          3 |
      Capsule, Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  45        |
      Pars Distalis, Granular Cell Tumor   |                                                                          |            |
          Malignant, Metastatic            |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          2 |
      Granulosa Cell Tumor Benign          |                                                                          |         10 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mixed Tumor Benign                   |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          2 |
      Axillary, Squamous Cell Carcinoma,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          4 |
      Axillary, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Deep Cervical, Squamous Cell         |                                                                          |            |
          Carcinoma, Metastatic, Skin      |                                                                          |          1 |
      Lumbar, Squamous Cell Carcinoma,     |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  33        |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  39        |
      Adenocarcinoma                       |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Squamous Cell Carcinoma, Multiple    |                                                                          |          1 |
      Back, Lymphoma Malignant Lymphocytic |                                                                          |          1 |
      Scapula, Basosquamous Tumor Malignant|                                                                          |          1 |
      Scapula, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Scapula, Squamous Cell Carcinoma     |                                                                          |         31 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple, Metastatic            |                                                                          |          2 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Metastatic                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Intercostal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Neck, Lymphoma Malignant Lymphocytic |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          6 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Granulosa Cell Tumor Malignant,      |                                                                          |            |
          Metastatic, Ovary                |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |         18 |
      Bronchiole, Adenocarcinoma,          |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  45        |
      Adenoma                              |                                                                          |          8 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 9| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                X         |             
      Hepatocellular Carcinoma             |       X                 X     X                          X  X            |             
      Hepatocellular Carcinoma, Multiple   |             X                                                            |             
      Hepatocellular Adenoma               |             X  X                       X                             X  X|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Lipoma                               |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoid Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     | X                                                  X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                                                          |             
      Pars Intermedia, Adenoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                 +                    +     +        +  +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangioma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  I  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X     X           X     X                    X                           |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|             
                                           | 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +|             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Polyp Adenomatous                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |    X                                                                     |             
      Hemangiosarcoma                      |                X                                                         |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X  X        X  X     X                 X                       X     X  X|             
      Hepatocellular Adenoma, Multiple     |                            X     X                 X  X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoid Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +              +                                      +|             
      Odontoma                             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                   X                                X                    X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                                                X         |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +                    +                 +               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                         +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangioma                  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +                                               +         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                        X|             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                      X                                      X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|             
                                           | 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/ML                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  M  +  +  M  +  M  +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                       X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatocellular Carcinoma             |                                                                          |          5 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |         14 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Carcinoid Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Odontoma                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Adenoma                     |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  43        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Femoral, Hemangioma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   5        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hemangiosarcoma                      |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 9| 8| 9| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 MG/ML                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  39        |
      Adenoma                              |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |          X                    X     X           X                        |             
      Hemangioma, Multiple                 |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |                                                    X           X         |             
      Hepatocellular Adenoma               | X     X                    X                                         X   |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +        +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                         +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                            X                             X               |             
      Capsule, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Deep Cervical, Mediastinal,|                                                                          |             
           Squamous Cell Carcinoma,        |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                      X   |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  +                                      +        +         |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Back, Squamous Cell Carcinoma        |                                                 X        X           X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Scapula, Basosquamous Tumor Malignant|    X                                         X                           |             
      Scapula, Squamous Cell Carcinoma     |             X                                         X  X               |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hindlimb, Hemangiosarcoma            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X        X  X        X  X           X                        |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X           X                       X            |             
      Bilateral, Adenoma                   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|             
                                           | 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangioma, Multiple                 |                                                                         X|             
      Hemangiosarcoma, Multiple            |                                        X        X                        |             
      Hepatocellular Carcinoma             | X                                         X        X                     |             
      Hepatocellular Adenoma               |                         X                 X                              |             
      Hepatocellular Adenoma, Multiple     |                               X     X                                    |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                    X              X     X|             
      Capsule, Lymphoma Malignant Mixed    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                  +  +                 +     +            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Deep Cervical, Mediastinal,|                                                                          |             
           Squamous Cell Carcinoma,        |                                                                          |             
          Metastatic, Skin                 | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                      X   |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                      X   |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                          +                       +     +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |             X              X                                         X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  +  M  +  M  M  M  +  M  M  M  +  M  M  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Back, Squamous Cell Carcinoma        |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Scapula, Basosquamous Tumor Malignant|                                                                          |             
      Scapula, Squamous Cell Carcinoma     | X     X              X           X  X              X     X               |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Hindlimb, Hemangiosarcoma            |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X  X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |       X                                                                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M     +  +  +  +  +  +|             
      Adenoma                              | X                          X                                      X      |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |             X              X                                         X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|             
                                           | 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    25 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangioma                           |                                                                          |          4 |
      Hemangioma, Multiple                 |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          2 |
      Hepatocellular Carcinoma             |                                                                          |          5 |
      Hepatocellular Adenoma               |                                                                          |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Adenoma                     |                                                                          |          5 |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Axillary, Deep Cervical, Mediastinal,|                                                                          |            |
           Squamous Cell Carcinoma,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   8        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Back, Squamous Cell Carcinoma        |                                                                          |          4 |
      Scapula, Basosquamous Tumor Malignant|                                                                          |          2 |
      Scapula, Squamous Cell Carcinoma     |                                                                          |         10 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hindlimb, Hemangiosarcoma            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          8 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  76                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 8| 8| 9| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    25 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  42        |
      Adenoma                              |                                                                          |          6 |
      Bilateral, Adenoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                          X               |             
      Hepatocellular Carcinoma             |                                                                      X   |             
      Hepatocellular Adenoma               | X              X        X     X     X                          X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                X                                               X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Medulla, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic, Skin                |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Subacute, Mild                   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +                    +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                    X                     |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic                      |                X                                                         |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +     +                    +                          +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                      X   |             
      Hemangiosarcoma                      |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  I  +  +  M  +  M  M  +  M  +  M  M  M  +  +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|             
                                           | 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Squamous Cell Carcinoma, Multiple    |    X                                                                     |             
      Back, Lymphoma Malignant Lymphocytic |                            X                                             |             
      Scapula, Basal Cell Carcinoma        |                                                             X            |             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Scapula, Squamous Cell Carcinoma     | X        X     X  X  X     X     X  X  X     X  X              X         |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |       X     X           X                 X        X     X  X     X  X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Skin                |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X              X              X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X  X     X     X     X              X           X  X           X  X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Squamous Cell Carcinoma, Metastatic  |          X                                                               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |    X           X                                               X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        M  +   |             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |    X        X           X                                                |             
      Hepatocellular Adenoma               |                   X  X        X                                          |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Squamous Cell Papilloma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Capsule, Adenoma                     |                      X                       X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Medulla, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +        +  M   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +        +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M        +  M   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  M   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Subacute, Mild                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                      +        +                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +        M  +   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic                      |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  M  +  +        M  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +  +  +  +  +  +              +        +                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  M  +  M  +  +  +  M  +  +  +  M  +  M  M  +  M        M  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M  M  +  M  M  +  M  M  M  +  M        +  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Keratoacanthoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|             
                             DAY ON TEST   | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|             
                                           | 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    50 MG/ML                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                                                       X                  |             
      Squamous Cell Carcinoma, Multiple    |                                                                          |             
      Back, Lymphoma Malignant Lymphocytic |                                                                          |             
      Scapula, Basal Cell Carcinoma        |                                                                          |             
      Scapula, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Scapula, Squamous Cell Carcinoma     | X  X     X  X     X  X     X  X     X  X  X     X  X  X  X               |             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                         X        X           X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Skin                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Alveolar/Bronchiolar Adenoma         |                   X              X     X     X  X                        |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X        X  X  X  X                       X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  M   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +        +  +   |             
      Adenoma                              |                      X                 X                                 |             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +                                                               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M     +                                                               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     M                                                               |  46        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +                                                               |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Adenoma               | X                                                                        |         10 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +                                                               |  50        |
      Submandibular Gland, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +                                                               |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +                                                               |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +                                                               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +                                                               |  49        |
      Capsule, Adenoma                     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +                                                               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Medulla, Squamous Cell Carcinoma,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +                                                               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +                                                               |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     +                                                               |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +                                                               |  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +                                                               |  49        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +                                                               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Subacute, Mild                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +                                                               |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +                                                               |  45        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic                      |                                                                          |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +                                                               |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  13        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  85                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +                                                               |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M     +                                                               |  27        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M     M                                                               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +                                                               |  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Squamous Cell Carcinoma, Multiple    |                                                                          |          1 |
      Back, Lymphoma Malignant Lymphocytic |                                                                          |          1 |
      Scapula, Basal Cell Carcinoma        |                                                                          |          1 |
      Scapula, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Scapula, Squamous Cell Carcinoma     |                                                                          |         27 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |         12 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +                                                               |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +                                                               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +                                                               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          8 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +                                                               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  86                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 0| 4| 2| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 4| 9| 8| 8| 9| 8| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    50 MG/ML                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +     +                                                               |  48        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +                                                               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +                                                               |  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +                                                               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Pheochromocytoma Complex, Diffuse,   |                                                                          |             
           Metastatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Hepatocellular Carcinoma             |                            X                                             |             
      Hepatocellular Adenoma               |                            X                                             |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |       X                       X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |             X                          X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Medulla, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic, Skin                |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |             X                                                            |             
      Axillary, Mediastinal, Squamous Cell |                                                                          |             
          Carcinoma, Metastatic, Skin      |                               X                                          |             
      Inguinal, Mediastinal, Squamous Cell |                                                                          |             
          Carcinoma, Metastatic, Skin      |                         X                                                |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |       X                                                                  |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Deep Cervical, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Skin      |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                    +                                +  +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                         X           X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|             
                                           | 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Scapula, Basosquamous Tumor Malignant|                   X                                                      |             
      Scapula, Squamous Cell Carcinoma     | X  X  X  X  X  X           X  X  X     X  X  X  X  X  X     X  X  X  X  X|             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                         X                                X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                       X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                                                   X      |             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                   X                                                      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X     X     X           X     X  X     X     X     X  X     X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +     +  +  +|             
      Adenoma                              |                   X                                X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            | X                             X        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Mesothelioma Malignant               |                                              X                           |             
      Pheochromocytoma Complex, Diffuse,   |                                                                          |             
           Metastatic                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                         X                       X                        |             
      Hepatocellular Carcinoma             |                X                       X                                 |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Capsule, Adenoma                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Medulla, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  I  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Axillary, Mediastinal, Squamous Cell |                                                                          |             
          Carcinoma, Metastatic, Skin      |                                                                          |             
      Inguinal, Mediastinal, Squamous Cell |                                                                          |             
          Carcinoma, Metastatic, Skin      |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                X                    X                                    |             
      Axillary, Squamous Cell Carcinoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Deep Cervical, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Skin      |    X                                                                     |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +           +        +  +     +                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  M  M  +  M  M  +  +  M  M  M  +  +  M  +                 M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M                 +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Squamous Cell Carcinoma              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|             
                                           | 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    100 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X                                                               |             
      Scapula, Basosquamous Tumor Malignant|                         X                       X                        |             
      Scapula, Squamous Cell Carcinoma     |    X  X  X  X     X  X     X  X  X     X     X     X  X                 X|             
      Scapula, Squamous Cell Carcinoma,    |                                                                          |             
           Multiple                        |                X                    X     X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                         X                       X                        |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |    X     X  X  X           X  X           X           X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +                 M|             
      Adenoma                              |          X                                X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Skin                 |                         X                       X                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +                 +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +|             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Mesothelioma Malignant               |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +     +  +  +                                                   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +     +  +  +                                                   |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Pheochromocytoma Complex, Diffuse,   |                                                                          |            |
           Metastatic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +     +  +  +                                                   |  50        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          2 |
      Hepatocellular Carcinoma             |                      X                                                   |          4 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +     +  +  +                                                   |  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +     +  +  +                                                   |  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +     +  +  +                                                   |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  94                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +     +  +  +                                                   |  50        |
      Medulla, Squamous Cell Carcinoma,    |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +     +  +  +                                                   |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +     +  +  +                                                   |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +     +  M  +                                                   |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +     +  +  +                                                   |  38        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +     +  +  +                                                   |  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +     +     +  +  +                                                   |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +     +  +  +                                                   |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     M     +  +  +                                                   |  46        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Axillary, Mediastinal, Squamous Cell |                                                                          |            |
          Carcinoma, Metastatic, Skin      |                                                                          |          1 |
      Inguinal, Mediastinal, Squamous Cell |                                                                          |            |
          Carcinoma, Metastatic, Skin      |                                                                          |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     M     +  +  +                                                   |  44        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          3 |
      Axillary, Squamous Cell Carcinoma,   |                                                                          |            |
           Metastatic, Skin                |    X                                                                     |          1 |
      Deep Cervical, Squamous Cell         |                                                                          |            |
          Carcinoma, Metastatic, Skin      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  95                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +     +  +  M                                                   |  27        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M     M     M  M  M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +     +  +  +                                                   |  50        |
      Squamous Cell Carcinoma              |                                                                          |          3 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Scapula, Basosquamous Tumor Malignant|                                                                          |          3 |
      Scapula, Squamous Cell Carcinoma     |    X     X           X                                                   |         37 |
      Scapula, Squamous Cell Carcinoma,    |                                                                          |            |
           Multiple                        |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +     +  +  +                                                   |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                      X                                                   |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +     +  +  +                                                   |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +     +  +  +                                                   |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +     +  +  +                                                   |  42        |
      Adenoma                              |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  96                                                               
NTP Experiment-Test: 05044-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 05/05/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:50:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5|                                            |            |
                                           | 9| 1| 8| 2| 8| 4| 4| 2| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    100 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
    ML                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +     +  +  +                                                   |  50        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +     +  +  +                                                   |  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +     +     +  +  +                                                   |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
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