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TDMS Study 05044-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE


NTP Experiment-Test: 05044-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            3            8           29                                     
    Dead                                               3            7            7            9                                     
    Accident                                           1                                                                            
    Drowned                                            1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           14           10                                     
    Moribund                                           7            7           15            2                                     
    Dead                                               4            1            6                                                  
    Accidently Killed                                  1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (49)         (48)         (49)                                   
      Sarcoma, Metastatic                                                        1 (2%)                                             
   Intestine Large, Cecum                             (50)         (48)         (49)         (50)                                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic                                           1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (49)         (50)         (50)                                   
   Intestine Small, Ileum                             (48)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)       1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         2 (4%)       3 (6%)       3 (6%)       2 (4%)                                
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic                                                                          1 (2%)                                
      Hepatocellular Adenoma                           7 (14%)      6 (12%)      5 (10%)      2 (4%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Metastatic,                                                                                  
           Metastatic                                                            1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic                                                     2 (4%)                                
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
   Mesentery                                          (5)          (4)          (2)                                                 
      Hemangioma                                       1 (20%)                                                                      
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (25%)                                                         
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (20%)                                                                      
                                                             Page   2                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic                                                        1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Metastatic                                1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          3 (6%)                    1 (2%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Tooth                                                           (1)                       (1)                                    
      Peridontal Tissue, Histiocytic Sarcoma,                                                                                       
          Metastatic                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Metastatic                                1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic                                                     1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, Capsule, Adenoma                                                1 (2%)                                             
      Capsule, Adenoma                                 2 (4%)       1 (2%)       6 (12%)      3 (6%)                                
      Capsule, Carcinoma                                                                      1 (2%)                                
      Extra Adrenal Tissue, Histiocytic Sarcoma,                                                                                    
           Metastatic                                               1 (2%)       1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma, Metastatic                                                     1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (48)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (49)         (48)         (47)         (45)                                   
      Pars Distalis, Adenoma                          17 (35%)     16 (33%)      5 (11%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Distalis, Granular Cell Tumor Malignant,                                                                                 
           Metastatic                                                                         1 (2%)                                
      Pars Intermedia, Adenoma                         2 (4%)                                 1 (2%)                                
   Thyroid Gland                                      (49)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Osteosarcoma, Metastatic, Metastatic             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (49)         (50)                                   
      Cystadenoma                                      1 (2%)                                                                       
      Granulosa Cell Tumor Malignant                                             2 (4%)       2 (4%)                                
      Granulosa Cell Tumor Benign                                                5 (10%)     10 (20%)                               
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (2%)       1 (2%)                                             
      Luteoma                                          1 (2%)                                                                       
      Mixed Tumor Benign                                                         9 (18%)      6 (12%)                               
      Bilateral, Histiocytic Sarcoma, Metastatic                    1 (2%)                                                          
      Bilateral, Mixed Tumor Benign                                              2 (4%)                                             
   Uterus                                             (50)         (49)         (49)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
      Polyp Stromal                                    1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Mast Cell Tumor NOS                              1 (2%)                                                                       
      Femoral, Hemangiosarcoma                                      1 (2%)                                                          
   Lymph Node                                         (49)         (49)         (47)         (50)                                   
      Squamous Cell Carcinoma, Metastatic                                        1 (2%)       2 (4%)                                
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Metastatic                                                             1 (2%)                                             
      Axillary, Adenocarcinoma, Metastatic,                                                                                         
          Mammary Gland                                                          1 (2%)                                             
      Axillary, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                       1 (2%)       1 (2%)                                
      Lumbar, Histiocytic Sarcoma, Metastatic                       1 (2%)                                                          
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Skin                                                       1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (49)         (47)         (48)                                   
      Histiocytic Sarcoma, Metastatic                                            1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)       5 (11%)      4 (8%)                                
      Axillary, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                                    1 (2%)                                
      Deep Cervical, Squamous Cell Carcinoma,                                                                                       
          Metastatic, Skin                                                                    1 (2%)                                
                                                             Page   4                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Lumbar, Squamous Cell Carcinoma, Metastatic,                                                                                  
           Skin                                                                               1 (2%)                                
   Lymph Node, Mesenteric                             (6)          (4)          (6)          (7)                                    
      Histiocytic Sarcoma, Metastatic                               1 (25%)                                                         
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangioma                                       2 (4%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic                      1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)                                             
      Capsule, Fibrous Histiocytoma                                              1 (2%)                                             
      Capsule, Histiocytic Sarcoma, Metastatic                      1 (2%)                                                          
   Thymus                                             (42)         (45)         (33)         (33)                                   
      Squamous Cell Carcinoma, Metastatic                                                     1 (3%)                                
      Thymoma Benign                                                             1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (41)         (41)         (39)                                   
      Adenocarcinoma                                   1 (2%)       1 (2%)       3 (7%)       4 (10%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    3 (6%)       2 (4%)                                
      Squamous Cell Carcinoma, Multiple                                                       1 (2%)                                
      Back, Fibrous Histiocytoma                                                 1 (2%)                                             
      Back, Osteosarcoma, Metastatic                                             1 (2%)                                             
      Back, Squamous Cell Carcinoma                                 1 (2%)       3 (6%)                                             
      Back, Squamous Cell Carcinoma, Multiple                                    1 (2%)                                             
      Scapula, Basosquamous Tumor Malignant                                      1 (2%)       1 (2%)                                
      Scapula, Fibrous Histiocytoma                                              1 (2%)                                             
      Scapula, Squamous Cell Carcinoma                              5 (10%)     14 (28%)     31 (62%)                               
      Scapula, Squamous Cell Carcinoma, Multiple                    1 (2%)      23 (46%)     10 (20%)                               
      Scapula, Squamous Cell Carcinoma, Multiple,                                                                                   
           Metastatic                                                                         2 (4%)                                
      Scapula, Squamous Cell Carcinoma, Metastatic                                            2 (4%)                                
      Sebaceous Gland, Adenocarcinoma                               1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Scapula, Squamous Cell                                                                                   
          Carcinoma, Metastatic                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (1)                       (2)          (2)                                    
      Back, Sarcoma, Metastatic                                                  1 (50%)                                            
      Intercostal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Skin                                                       1 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       5 (10%)      8 (16%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                  1 (2%)                                             
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                                 1 (2%)       2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Skin                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic,                                                                                         
          Metastatic                                                1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (2%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic                                                     2 (4%)                                
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)       9 (18%)     18 (36%)                               
      Bronchiole, Adenocarcinoma, Metastatic                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (43)         (46)         (42)         (45)                                   
      Adenoma                                          5 (12%)      1 (2%)       4 (10%)      8 (18%)                               
      Carcinoma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Metastatic                   1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic                                                     1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)       3 (6%)                                
   Urinary Bladder                                    (49)         (49)         (48)         (50)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
      Leukemia Granulocytic                                                      1 (2%)                                             
      Lymphoma Malignant Histiocytic                                             2 (4%)                                             
      Lymphoma Malignant Lymphocytic                   4 (8%)       2 (4%)                    1 (2%)                                
      Lymphoma Malignant Mixed                        10 (20%)      3 (6%)       2 (4%)                                             
      Lymphoma Malignant Undifferentiated Cell         4 (8%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   7                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          36          47          46                                       
     Total Primary Neoplasms                           76          59         123          99                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          25          34          29                                       
     Total Benign Neoplasms                            52          33          51          42                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          22          44          44                                       
     Total Malignant Neoplasms                         23          26          72          57                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           7          20          29                                       
     Total Metastatic Neoplasm                          8          19          40          53                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   8                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            4           27           30                                     
    Dead                                               6           11           17           20                                     
    Drowned                                            3                         2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           35            4                                                  
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (50)         (48)         (50)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (50)         (46)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Pheochromocytoma Complex, Diffuse, Metastatic                                           1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (49)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                               2 (4%)                                
      Hemangioma                                       1 (2%)       4 (8%)                                                          
      Hemangioma, Multiple                                          1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
      Hemangiosarcoma, Multiple                                     2 (4%)                                                          
      Hepatocellular Carcinoma                         5 (10%)      5 (10%)      4 (8%)       4 (8%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          14 (28%)      6 (12%)     10 (20%)      1 (2%)                                
      Hepatocellular Adenoma, Multiple                 4 (8%)       2 (4%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                                               2 (4%)                                
   Mesentery                                          (1)          (1)                       (1)                                    
      Lipoma                                           1 (100%)                                                                     
   Pancreas                                           (49)         (50)         (50)         (49)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Carcinoid Tumor Malignant                        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
   Tooth                                              (4)          (3)                       (1)                                    
      Odontoma                                         1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                  3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (49)         (50)                                   
      Capsule, Adenoma                                 5 (10%)      5 (10%)      3 (6%)       1 (2%)                                
   Adrenal Gland, Cortex                              (50)         (49)         (49)         (50)                                   
      Medulla, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Skin                                                                  1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (48)         (50)         (47)         (48)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (43)         (47)         (42)         (38)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)         (49)         (48)                                   
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (1)          (1)                                    
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Interstitial Cell, Adenoma                                    1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (49)         (49)                                   
      Femoral, Hemangioma                              1 (2%)                                                                       
   Lymph Node                                         (49)         (49)         (45)         (46)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (2%)       1 (2%)                                
      Axillary, Deep Cervical, Mediastinal,                                                                                         
          Squamous Cell Carcinoma, Metastatic, Skin                 1 (2%)                                                          
      Axillary, Mediastinal, Squamous Cell                                                                                          
          Carcinoma, Metastatic, Skin                                                         1 (2%)                                
                                                             Page  10                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Inguinal, Mediastinal, Squamous Cell                                                                                          
          Carcinoma, Metastatic, Skin                                                         1 (2%)                                
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic                                                             1 (2%)                                             
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Skin                                          1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (48)         (46)         (43)         (44)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                  2 (5%)       3 (7%)                                
      Axillary, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Skin                                                                    1 (2%)                                
      Deep Cervical, Squamous Cell Carcinoma,                                                                                       
          Metastatic, Skin                                                                    1 (2%)                                
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Skin                                                                    1 (2%)                                
   Lymph Node, Mesenteric                             (5)          (8)          (13)         (9)                                    
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Hemangioma                                                    1 (2%)       1 (2%)                                             
      Hemangiosarcoma                                  3 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Keratoacanthoma                                                            1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)       2 (4%)       3 (6%)                                
      Squamous Cell Carcinoma, Multiple                                          1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
      Back, Squamous Cell Carcinoma                                 4 (8%)                                                          
      Scapula, Basal Cell Carcinoma                                              1 (2%)                                             
      Scapula, Basosquamous Tumor Malignant                         2 (4%)                    3 (6%)                                
      Scapula, Squamous Cell Carcinoma                             10 (20%)     27 (54%)     37 (74%)                               
      Scapula, Squamous Cell Carcinoma, Multiple                    2 (4%)      12 (24%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Diaphragm, Squamous Cell Carcinoma,                                                                                           
          Metastatic, Skin                                                       1 (100%)                                           
      Hindlimb, Hemangiosarcoma                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     7 (14%)      8 (16%)      8 (16%)      2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                               3 (6%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                     2 (4%)      16 (32%)     20 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (39)         (42)         (48)         (42)                                   
      Adenoma                                          3 (8%)       6 (14%)      3 (6%)       4 (10%)                               
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, Adenoma                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                               2 (4%)                                
      Squamous Cell Carcinoma, Metastatic                                        1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Skin                     2 (4%)       3 (6%)       5 (10%)                               
   Urinary Bladder                                    (50)         (48)         (49)         (48)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant Histiocytic                                1 (2%)                    1 (2%)                                
      Lymphoma Malignant Lymphocytic                                1 (2%)       2 (4%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       4 (8%)                                                          
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)                                                          
      Mesothelioma Malignant                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05044-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:35:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          40          42          47                                       
     Total Primary Neoplasms                           62          73          84          64                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          26          23           7                                       
     Total Benign Neoplasms                            43          37          31           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          26          40          47                                       
     Total Malignant Neoplasms                         19          36          53          55                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2          17          26                                       
     Total Metastatic Neoplasm                          2           6          31          52                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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