National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1287

TDMS Study 05044-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/06/94   
EXP: 05044             4-VINYL-1-CYCLOHEXENE DIEPOXIDE         TIME: 19:52:34   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DERMAL,SOLUTION             NTP C#: 60139A   
CONT: N01-CP-95653                                             CAS: 106-87-6    
PATHOLOGIST: M. RYAN                                                            
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/06/94  
EXP: 05044             4-VINYL-1-CYCLOHEXENE DIEPOXIDE         TIME: 19:52:34  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DERMAL,SOLUTION             NTP C#: 60139A  
CONT: N01-CP-95653                                             CAS: 106-87-6   
PATHOLOGIST: M. RYAN                                                           

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/ML                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 9      CENSORED DEATHS 13   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      4     5     215   495   574   587   600   612   639                       |
 |  CENSORED DEATHS                                                               |
 |      438   458   458   458   458   458   458   459   459   459                 |
 |      459   624   624                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 MG/ML                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      14    30    38    381   470   481   525   590   609   653                 |
 |      654   673   694   698   721                                               |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   459   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/ML                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 44     CENSORED DEATHS 12   TERMINAL 4         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      4     4     4     4     30    218   244   411   435   436                 |
 |      520   523   543   564   572   594   604   613   614   625                 |
 |      625   625   625   625   635   643   652   672   678   684                 |
 |      687   687   687   688   689   695   696   698   707   708                 |
 |      711   711   723   726                                                     |
 |  CENSORED DEATHS                                                               |
 |      42    458   458   458   458   458   459   459   459   459                 |
 |      459   527                                                                 |
 |                                                                                |
 ==================================================================================

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 100 MG/ ML                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 50     CENSORED DEATHS 10   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      29    204   204   315   376   376   416   419   429   449                 |
 |      450   451   451   452   452   466   477   480   486   493                 |
 |      493   498   499   505   506   508   509   510   514   515                 |
 |      515   516   520   522   523   534   536   544   550   558                 |
 |      565   565   565   572   572   577   577   579   579   579                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/ML    |    96.7  96.7  95.0  95.0  95.0  95.0  92.9  86.7  82.5  82.5      |
 |           |                                                                    |
 |           |                                                                    |
 |25 MG/ML   |    95.0  95.0  95.0  95.0  93.3  89.3  87.2  85.2  79.1  71.0      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/ML   |    91.7  91.7  88.3  88.3  86.6  83.2  76.7  68.0  46.0   8.8      |
 |           |                                                                    |
 |           |                                                                    |
 |100 MG/ ML |    98.3  98.3  95.0  93.3  86.7  68.6  25.7   0.0   0.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/ML      25 MG/ML     50 MG/ML     100 MG/ M|
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.5%        71.0%         8.8%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.306      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       414.6        482.1        541.8        479.6    |
 |NATURAL DEATHS (C)      |       (88.3)       (65.6)       (33.7)       (14.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       628.4        622.2        531.8        476.1    |
 |(STANDARD ERROR)        |       (21.8)       (23.0)       (27.1)       (12.4)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 593 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/ML                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 6      CENSORED DEATHS 12   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      392   451   451   500   534   569                                         |
 |  CENSORED DEATHS                                                               |
 |      64    437   458   458   458   458   458   459   459   459                 |
 |      459   459                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 MG/ML                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 10     CENSORED DEATHS 11   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      31    196   217   415   428   457   515   553   556   576                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |      477                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/ML                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      3     4     45    402   436   452   464   495   497   566                 |
 |      569   572   579   579   584                                               |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 593 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 100 MG/ ML                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 38     CENSORED DEATHS 10   TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      2     162   186   376   388   407   431   444   449   464                 |
 |      474   474   487   495   499   499   503   519   523   523                 |
 |      532   535   535   541   541   544   550   550   550   558                 |
 |      558   562   578   578   579   579   579   579                             |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                          4-VINYL-1-CYCLOHEXENE DIEPOXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 593 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   593 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/ML    |   100.0 100.0 100.0 100.0  98.3  94.9  90.6  88.5  88.5  88.5      |
 |           |                                                                    |
 |           |                                                                    |
 |25 MG/ML   |    98.3  98.3  95.0  95.0  93.3  90.0  87.9  81.6  81.6  81.6      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/ML   |    95.0  95.0  95.0  95.0  93.3  88.0  83.9  71.6  71.6  71.6      |
 |           |                                                                    |
 |           |                                                                    |
 |100 MG/ ML |    98.3  96.7  95.0  95.0  90.0  78.8  49.8  24.9  24.9  24.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 MG/ML      25 MG/ML     50 MG/ML     100 MG/ M|
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       88.5%        81.6%        71.6%        24.9%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.417      P=0.061      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       482.8        394.4        416.5        482.4    |
 |NATURAL DEATHS (C)      |       (26.2)       (58.4)       (55.5)       (20.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       548.2        535.6        526.5        500.6    |
 |(STANDARD ERROR)        |       (11.4)       (14.0)       (17.1)       (14.0)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/ML          = 1
                                                        25 MG/ML         = 2
                                                        50 MG/ML         = 3
                                                        100 MG/ ML       = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 112   4
      |  12   22                         41
      |        2                         41               4          2                1
      |  3    3                            3              4        4 2             22 1           1
   90 +                                    3   3                   4      4         2      2      1 1  1
      |                                        3                         34 43             2          21 1
      |                                                                     4   4                     2 21   1
      |                                                                      3             3            2    1 2            1
   80 +                                                                                    3  3                2   2
      |                                                                                       3  3                 2  2
      |                                                                         4 4              33
      |                                                                           4 4             3   3               2  2
P  70 +                                                                                               3 3                2  2
E     |                                                                             444                 33
R     |
C     |                                                                               44                 3 3
E  60 +
N     |                                                                                44
T     |
      |                                                                                                    33
S  50 +                                                                                                     33
U     |                                                                                 44                   3 3
R     |                                                                                                        3  33
V     |                                                                                                            33
I  40 +                                                                                                             33
V     |                                                                                  4 4
A     |
L     |                                                                                    4 4
   30 +
      |                                                                                      44                      33
      |                                                                                       44
      |                                                                                        444                    33
   20 +                                                                                                                33
      |
      |                                                                                          44
      |                                                                                                                 3 3
   10 +                                                                                           44                      3 3
      |
      |
      |
    0 +                                                                                            4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/ML          = 1
                                                        25 MG/ML         = 2
                                                        50 MG/ML         = 3
                                                        100 MG/ ML       = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

       |
       |
   100 +  13     2                                                                 1
       |   3     2 3                     4   42   2                                1           1
       |           3                         4    2                             4    3  2      1        1
       |                                                                        4  4 3 42  23  32       1     1
    90 +                                                                               4   4   323        2   1      1
       |                                                                                   4 4 4 3    3   2      2   1   1
       |                                                                                       4 4    3          223
       |                                                                                         44               23 32  2
 P  80 +                                                                                          4  4
 E     |                                                                                             44              33
 R     |                                                                                              4 4
 C     |                                                                                                              33 3
 E  70 +
 N     |                                                                                                4   4
 T     |
       |                                                                                                    44
 S  60 +                                                                                                     44
 U     |
 R     |                                                                                                      44
 V     |
 I  50 +                                                                                                       4 4
 V     |
 A     |
 L     |                                                                                                         44
    40 +                                                                                                          44
       |                                                                                                           4  4
       |
       |
    30 +
       |
       |                                                                                                              4  4
       |
    20 +
       |
       ---+------------+------------+------------+------------+------------+------------+------------+------------+------------+--
          0           10           20           30           40           50           60           70           80           90

                                                                   WEEK

NOTE: 13 obs hidden.

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