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TDMS Study 05044-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE


NTP Experiment-Test: 05044-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           13           21                                                  
    Moribund                                          15           14           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           23           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (47)         (45)                                                
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (47)         (50)         (48)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                             1 (2%)       3 (6%)                                             
   Intestine Large, Rectum                            (48)         (48)         (48)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                5 (10%)      7 (15%)      4 (8%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (49)                                                
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (44)         (42)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                38 (76%)     32 (64%)     35 (70%)                                            
      Clear Cell Focus                                              2 (4%)                                                          
      Degeneration, Cystic                                          1 (2%)                                                          
      Eosinophilic Focus                                            1 (2%)                                                          
      Fatty Change                                     9 (18%)      5 (10%)      1 (2%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Focal                                            1 (2%)                                                          
      Inflammation, Acute, Necrotizing                 1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  4 (8%)       2 (4%)                                             
      Bile Duct, Hyperplasia                           7 (14%)     10 (20%)     14 (28%)                                            
      Centrilobular, Necrosis                          5 (10%)      5 (10%)      1 (2%)                                             
      Hepatocyte, Regeneration                         1 (2%)                                                                       
   Mesentery                                          (4)          (2)                                                              
      Inflammation, Acute, Necrotizing                 1 (25%)                                                                      
      Inflammation, Chronic Active                     3 (75%)                                                                      
      Artery, Inflammation, Chronic Active                          1 (50%)                                                         
   Pancreas                                           (48)         (47)         (48)                                                
      Focal Cellular Change                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       1 (2%)                                                          
      Metaplasia                                       1 (2%)                                                                       
      Acinus, Atrophy                                 19 (40%)     17 (36%)     17 (35%)                                            
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Pharynx                                                         (1)          (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
   Salivary Glands                                    (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Focal Cellular Change                                         1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Duct, Inflammation, Chronic Active                                         1 (2%)                                             
   Stomach, Forestomach                               (50)         (48)         (50)                                                
      Inflammation, Chronic Active                     2 (4%)       3 (6%)                                                          
      Ulcer                                            5 (10%)                                                                      
      Epithelium, Hyperplasia                          5 (10%)      4 (8%)                                                          
   Stomach, Glandular                                 (50)         (48)         (50)                                                
      Inflammation, Acute, Necrotizing                 4 (8%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
   Tooth                                              (2)          (1)          (2)                                                 
      Dysplasia                                        1 (50%)                                                                      
      Gingiva, Hyperplasia, Squamous                                             1 (50%)                                            
      Peridontal Tissue, Inflammation, Suppurative     1 (50%)      1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Degeneration, Chronic                           45 (90%)     40 (80%)     35 (70%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Atrium, Thrombosis                               2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (48)         (50)                                                
      Hyperplasia                                     38 (76%)     29 (60%)     34 (68%)                                            
      Hypertrophy                                      4 (8%)       1 (2%)       2 (4%)                                             
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (48)         (50)                                                
      Hyperplasia                                      9 (18%)     10 (21%)      6 (12%)                                            
   Islets, Pancreatic                                 (48)         (48)         (48)                                                
      Hyperplasia                                      2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Parathyroid Gland                                  (47)         (43)         (48)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (47)         (49)         (48)                                                
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Degeneration, Focal                                         1 (2%)                                             
      Pars Distalis, Hyperplasia                      19 (40%)     20 (41%)     15 (31%)                                            
   Thyroid Gland                                      (46)         (48)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      C-Cell, Hyperplasia                             37 (80%)     33 (69%)     23 (47%)                                            
      Follicular Cell, Hyperplasia                     2 (4%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (50)         (49)                                                
      Hyperplasia                                      6 (13%)      3 (6%)       4 (8%)                                             
      Inflammation, Acute, Necrotizing                              1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                     8 (18%)      2 (4%)       5 (10%)                                            
      Duct, Hyperplasia                                             1 (2%)       2 (4%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Cyst                                             4 (8%)       5 (10%)      9 (18%)                                            
   Uterus                                             (50)         (50)         (50)                                                
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Prolapse                                                      1 (2%)       1 (2%)                                             
   Vagina                                             (3)                                                                           
      Inflammation, Suppurative                        3 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)                                                
      Femoral, Hyperplasia, Reticulum Cell             4 (8%)       5 (10%)      6 (12%)                                            
      Femoral, Myelofibrosis                           3 (6%)       1 (2%)                                                          
      Femoral, Necrosis                                1 (2%)                    1 (2%)                                             
      Femoral, Myeloid Cell, Hyperplasia                                         1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Inflammation, Acute, Necrotizing                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (3)                       (2)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Edema                                            1 (33%)                   1 (50%)                                            
   Spleen                                             (50)         (50)         (49)                                                
      Fibrosis                                         2 (4%)       2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           3 (6%)                                             
      Hemorrhage, Chronic                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)                                                
      Hyperplasia, Cystic                             41 (82%)     20 (41%)     37 (74%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Back, Acanthosis                                 1 (2%)       4 (8%)      11 (22%)                                            
      Back, Sebaceous Gland, Hypertrophy                                        15 (30%)                                            
      Hair Follicle, Inflammation, Chronic             1 (2%)                                                                       
      Scapula, Acanthosis                              4 (8%)      33 (66%)     42 (84%)                                            
      Scapula, Cyst Epithelial Inclusion                            1 (2%)                                                          
      Scapula, Inflammation, Acute, Necrotizing        1 (2%)       1 (2%)       1 (2%)                                             
      Scapula, Inflammation, Chronic Active                         1 (2%)                                                          
      Sebaceous Gland, Scapula, Hypertrophy            1 (2%)      20 (40%)     43 (86%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Fibrous Osteodystrophy                  1 (2%)                                                                       
      Femur, Fibrous Osteodystrophy                    1 (2%)                                                                       
      Mandible, Fibrous Osteodystrophy                 1 (2%)                                                                       
      Tarsal, Hyperostosis                             1 (2%)                                                                       
      Tarsal, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                     12 (24%)      7 (14%)      5 (10%)                                            
      Infarct                                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Inflammation, Chronic Active                     4 (8%)       4 (8%)       6 (12%)                                            
      Mineralization                                   1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                              2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mediastinum, Inflammation, Chronic Active                                  1 (2%)                                             
   Nose                                               (49)         (50)         (49)                                                
      Hyperplasia, Squamous                                                      1 (2%)                                             
      Mucosa, Inflammation, Suppurative                             2 (4%)       3 (6%)                                             
      Mucosa, Thrombosis                               2 (4%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       2 (4%)       3 (6%)                                             
   Trachea                                            (50)         (50)         (49)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (3)          (3)                                                 
      Degeneration                                     4 (80%)      2 (67%)      2 (67%)                                            
   Harderian Gland                                                              (2)                                                 
      Inflammation, Chronic                                                      2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Bacterium                                        1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Nephropathy, Chronic                            47 (94%)     45 (90%)     46 (94%)                                            
      Cortex, Atrophy, Focal                                        1 (2%)                                                          
      Pelvis, Inflammation, Suppurative                             1 (2%)                                                          
      Renal Tubule, Hyperplasia                        6 (12%)                                                                      
   Urinary Bladder                                    (50)         (50)         (48)                                                
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          31           37           29                                                  
    Dead                                              12            5           16                                                  
    Drowned                                                                      1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            8            4                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
   Intestine Large, Cecum                             (45)         (48)         (40)                                                
      Inflammation, Suppurative                        1 (2%)                    1 (3%)                                             
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (3%)                                             
      Thrombosis                                       1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (49)         (40)                                                
      Mineralization                                   5 (10%)      3 (6%)                                                          
      Parasite Metazoan                                2 (4%)       2 (4%)                                                          
   Intestine Large, Rectum                            (48)         (48)         (44)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   2 (4%)       2 (4%)                                                          
      Parasite Metazoan                                4 (8%)                    1 (2%)                                             
   Intestine Small, Duodenum                          (48)         (50)         (45)                                                
      Inflammation, Acute, Necrotizing                 4 (8%)       5 (10%)      1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (49)         (37)                                                
      Inflammation, Acute, Necrotizing                 1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                15 (30%)     15 (30%)     10 (20%)                                            
      Degeneration, Cystic                             7 (14%)      7 (14%)      3 (6%)                                             
      Eosinophilic Focus                                            1 (2%)                                                          
      Fatty Change                                     5 (10%)      6 (12%)      2 (4%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Necrotizing                              3 (6%)       2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Cyst                                                            1 (2%)                                             
      Bile Duct, Hyperplasia                          20 (40%)     39 (78%)     19 (38%)                                            
      Centrilobular, Necrosis                         11 (22%)      9 (18%)      8 (16%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Regeneration                                      1 (2%)                                                          
   Mesentery                                          (7)          (6)          (6)                                                 
      Inflammation, Acute, Necrotizing                 1 (14%)                   2 (33%)                                            
      Inflammation, Chronic Active                     2 (29%)                   1 (17%)                                            
      Artery, Mineralization                           4 (57%)      3 (50%)      1 (17%)                                            
   Pancreas                                           (50)         (50)         (45)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Acinus, Atrophy                                 23 (46%)     24 (48%)     19 (42%)                                            
      Acinus, Hyperplasia                              2 (4%)                    1 (2%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
   Pharynx                                            (2)          (2)                                                              
      Inflammation, Suppurative                        1 (50%)      2 (100%)                                                        
   Salivary Glands                                    (50)         (50)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
      Artery, Mineralization                           2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (47)                                                
      Inflammation, Chronic Active                     1 (2%)      10 (20%)      2 (4%)                                             
      Mineralization                                   6 (12%)      3 (6%)       1 (2%)                                             
      Ulcer                                            8 (16%)      6 (12%)      8 (17%)                                            
      Epithelium, Hyperplasia                          6 (12%)     10 (20%)      2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (48)                                                
      Inflammation, Acute, Necrotizing                11 (22%)      3 (6%)       5 (10%)                                            
      Mineralization                                  10 (20%)     11 (22%)      4 (8%)                                             
   Tooth                                              (2)          (5)                                                              
      Dysplasia                                                     1 (20%)                                                         
      Peridontal Tissue, Inflammation, Suppurative     2 (100%)     4 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (7)          (5)          (2)                                                 
      Aneurysm                                                      1 (20%)                                                         
      Aorta, Mineralization                            7 (100%)     4 (80%)      2 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Degeneration, Chronic                           45 (90%)     42 (84%)     48 (96%)                                            
      Inflammation, Suppurative                                     2 (4%)       3 (6%)                                             
      Mineralization                                   9 (18%)      7 (14%)      3 (6%)                                             
      Atrium, Thrombosis                               4 (8%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Hyperplasia                                     23 (46%)     24 (48%)     31 (62%)                                            
      Hypertrophy                                      1 (2%)                                                                       
      Necrosis                                                      3 (6%)       2 (4%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Hyperplasia                                     28 (56%)     28 (56%)     20 (40%)                                            
   Islets, Pancreatic                                 (50)         (50)         (46)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       5 (11%)                                            
   Parathyroid Gland                                  (49)         (45)         (45)                                                
      Hyperplasia                                     14 (29%)     14 (31%)      4 (9%)                                             
      Hypertrophy                                                   1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (48)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      23 (46%)     10 (20%)     11 (23%)                                            
      Pars Distalis, Mineralization                    2 (4%)       1 (2%)                                                          
      Pars Distalis, Necrosis                                       1 (2%)                                                          
   Thyroid Gland                                      (48)         (50)         (43)                                                
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Pigmentation, Lipofuscin                                      1 (2%)                                                          
      C-Cell, Hyperplasia                             28 (58%)     30 (60%)     22 (51%)                                            
      Follicular Cell, Hyperplasia                                  2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (2)                       (1)                                                 
      Mineralization                                   2 (100%)                  1 (100%)                                           
   Epididymis                                         (50)         (50)         (48)                                                
      Mineralization                                                             1 (2%)                                             
   Penis                                                                        (1)                                                 
      Inflammation, Acute, Necrotizing                                           1 (100%)                                           
   Preputial Gland                                    (49)         (49)         (50)                                                
      Hyperplasia                                      1 (2%)                    3 (6%)                                             
      Inflammation, Chronic Active                    11 (22%)     16 (33%)      9 (18%)                                            
      Duct, Hyperplasia                                             1 (2%)       1 (2%)                                             
   Prostate                                           (49)         (50)         (50)                                                
      Inflammation, Chronic Active                    34 (69%)     32 (64%)     41 (82%)                                            
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Thrombosis                                       1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   9 (18%)      7 (14%)     14 (28%)                                            
      Seminiferous Tubule, Atrophy                     9 (18%)      2 (4%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Femoral, Myelofibrosis                           3 (6%)       1 (2%)       4 (8%)                                             
   Lymph Node, Mandibular                             (50)         (49)         (50)                                                
      Edema                                                                      2 (4%)                                             
      Inflammation, Acute, Necrotizing                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (7)          (10)         (3)                                                 
      Edema                                            1 (14%)      4 (40%)                                                         
      Hemorrhage                                                    1 (10%)                                                         
      Inflammation, Acute, Necrotizing                              1 (10%)                                                         
   Spleen                                             (50)         (50)         (49)                                                
      Abscess                                                                    1 (2%)                                             
      Amyloid Deposition                                                         1 (2%)                                             
      Fibrosis                                         8 (16%)      8 (16%)      7 (14%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage, Chronic                                           1 (2%)                                                          
      Necrosis                                                      3 (6%)       3 (6%)                                             
   Thymus                                             (41)         (40)         (42)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute, Necrotizing                              1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (48)         (42)                                                
      Hyperplasia, Cystic                             34 (76%)     25 (52%)     36 (86%)                                            
      Mineralization                                   1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Abscess                                          2 (4%)                                                                       
      Acanthosis                                                    2 (4%)       1 (2%)                                             
      Cyst Epithelial Inclusion, Multiple                                        1 (2%)                                             
      Inflammation, Acute, Necrotizing                 3 (6%)       1 (2%)       2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Back, Acanthosis                                              6 (12%)      8 (16%)                                            
      Back, Inflammation, Acute, Necrotizing                        1 (2%)                                                          
      Back, Sebaceous Gland, Hypertrophy                            4 (8%)       8 (16%)                                            
      Scapula, Acanthosis                                          39 (78%)     40 (80%)                                            
      Scapula, Cyst Epithelial Inclusion                            1 (2%)       1 (2%)                                             
      Scapula, Hypertrophy                                          2 (4%)                                                          
      Scapula, Inflammation, Acute, Necrotizing        1 (2%)                    1 (2%)                                             
      Sebaceous Gland, Hypertrophy                                  1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Sebaceous Gland, Scapula, Hypertrophy                        28 (56%)     39 (78%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Fibrous Osteodystrophy                 13 (26%)     12 (24%)      4 (8%)                                             
      Femur, Fibrous Osteodystrophy                   13 (26%)     12 (24%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Compression                                      7 (14%)      7 (14%)     11 (22%)                                            
      Infarct                                          4 (8%)       2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Infarct                                                       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                    11 (22%)     15 (30%)      1 (2%)                                             
      Mineralization                                   9 (18%)      7 (14%)      2 (4%)                                             
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              3 (6%)                                                          
      Artery, Mediastinum, Mineralization              3 (6%)       6 (12%)                                                         
      Mediastinum, Inflammation, Chronic Active                     1 (2%)                                                          
      Pleura, Inflammation, Suppurative                                          2 (4%)                                             
   Nose                                               (50)         (50)         (49)                                                
      Mucosa, Inflammation, Suppurative               21 (42%)     12 (24%)     13 (27%)                                            
      Mucosa, Thrombosis                               1 (2%)       1 (2%)       3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     3 (6%)       2 (4%)       4 (8%)                                             
      Septum, Necrosis                                 1 (2%)                    1 (2%)                                             
   Trachea                                            (50)         (49)         (48)                                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (3)          (6)                                                 
      Degeneration                                     3 (43%)      2 (67%)      6 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05044-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 10:15:13  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/ML      50 MG/ML     100 MG/                                                
                                                                             ML                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Hydronephrosis                                                1 (2%)                                                          
      Mineralization                                   9 (18%)      7 (14%)      5 (10%)                                            
      Nephropathy, Chronic                            50 (100%)    49 (98%)     49 (100%)                                           
      Pelvis, Inflammation, Suppurative                2 (4%)       5 (10%)      4 (8%)                                             
      Renal Tubule, Cytoplasmic Alteration             2 (4%)                                                                       
      Renal Tubule, Hyperplasia                        2 (4%)       6 (12%)      4 (8%)                                             
      Renal Tubule, Necrosis                           1 (2%)                                                                       
   Urethra                                            (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Urinary Bladder                                    (49)         (50)         (49)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)                                                                       
      Mineralization                                   2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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