National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1337

TDMS Study 05049-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             DICHLORVOS


NTP Experiment-Test: 05049-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: GAVAGE                                                                                                     Time: 05:32:15




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15            5            9                                                  
    Accident                                           6            5            2                                                  
    Dead                                               3           11            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           29           34                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (48)         (50)                                                
      Diverticulum                                     1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Muscularis, Inflammation, Chronic                             1 (2%)                                                          
   Gallbladder                                        (33)         (41)         (45)                                                
      Cyst                                                                       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
   Intestine Large                                    (49)         (50)         (50)                                                
      Cecum, Hyperplasia, Lymphoid                     2 (4%)                                                                       
      Cecum, Mucosa, Necrosis                                                    1 (2%)                                             
   Intestine Small                                    (46)         (49)         (48)                                                
      Duodenum, Amyloid Deposition                                               1 (2%)                                             
      Duodenum, Hyperplasia, Re Cell                   1 (2%)                                                                       
      Ileum, Amyloid Deposition                                                  3 (6%)                                             
      Jejunum, Amyloid Deposition                                                2 (4%)                                             
      Jejunum, Fibrosis                                             1 (2%)                                                          
      Jejunum, Inflammation, Suppurative                            1 (2%)                                                          
      Jejunum, Necrosis                                             1 (2%)                                                          
      Jejunum, Peyer's Patch, Hyperplasia, Lymphoid                 1 (2%)       3 (6%)                                             
      Jejunum, Peyer's Patch, Hyperplasia,                                                                                          
          Mononuclear Cell                             1 (2%)                                                                       
      Mucosa, Ileum, Dysplasia                         1 (2%)                                                                       
      Submucosa, Ileum, Infiltration Cellular,                                                                                      
           Plasma Cell                                 1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Clear Cell Focus                                                           1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 8 (16%)      5 (10%)      3 (6%)                                             
      Infiltration Cellular, Mononuclear Cell                                    1 (2%)                                             
      Inflammation, Chronic                           15 (30%)      5 (10%)     13 (26%)                                            
      Inflammation, Chronic Active                     2 (4%)       3 (6%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Suppurative                                     1 (2%)                                                          
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             
      Hepatocyte, Cytoplasmic Alteration               1 (2%)                    1 (2%)                                             
      Hepatocyte, Karyomegaly                          1 (2%)       1 (2%)       1 (2%)                                             
      Hepatocyte, Necrosis                             5 (10%)      8 (16%)      5 (10%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            4 (8%)       2 (4%)       4 (8%)                                             
      Kupffer Cell, Hyperplasia                        3 (6%)       5 (10%)      4 (8%)                                             
      Kupffer Cell, Pigmentation                       3 (6%)                                                                       
   Mesentery                                          (13)         (10)         (7)                                                 
      Inflammation, Chronic                            1 (8%)       2 (20%)                                                         
      Inflammation, Chronic Active                                  1 (10%)                                                         
      Inflammation, Suppurative                        5 (38%)      2 (20%)      1 (14%)                                            
      Artery, Hypertrophy                              1 (8%)                                                                       
      Artery, Inflammation, Chronic                    2 (15%)                                                                      
      Fat, Inflammation, Chronic Active                                          1 (14%)                                            
      Fat, Mineralization                                                        3 (43%)                                            
      Fat, Necrosis, Focal                             1 (8%)       1 (10%)      4 (57%)                                            
   Pancreas                                           (47)         (49)         (49)                                                
      Atrophy                                          2 (4%)                    1 (2%)                                             
      Cytoplasmic Alteration                           1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic                            4 (9%)       3 (6%)       1 (2%)                                             
      Acinus, Vacuolization Cytoplasmic                                          1 (2%)                                             
   Salivary Glands                                    (49)         (50)         (50)                                                
      Inflammation, Chronic                            5 (10%)      6 (12%)      7 (14%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
   Stomach                                            (49)         (49)         (50)                                                
      Forestomach, Cyst                                1 (2%)                                                                       
      Forestomach, Diverticulum                        1 (2%)                    1 (2%)                                             
      Forestomach, Erosion                             1 (2%)                                                                       
      Forestomach, Foreign Body                                                  1 (2%)                                             
      Forestomach, Hyperplasia, Focal                  6 (12%)      6 (12%)      5 (10%)                                            
      Forestomach, Inflammation, Acute                 1 (2%)                                                                       
      Forestomach, Inflammation, Chronic               1 (2%)                                                                       
      Forestomach, Inflammation, Chronic Active                     2 (4%)       2 (4%)                                             
      Forestomach, Inflammation, Suppurative                                     2 (4%)                                             
      Forestomach, Mineralization                                   1 (2%)                                                          
      Forestomach, Mucosa, Hyperplasia, Focal                       1 (2%)                                                          
      Glandular, Atrophy                                                         1 (2%)                                             
      Glandular, Cyst                                               2 (4%)                                                          
      Glandular, Edema                                 1 (2%)                                                                       
      Glandular, Erosion                               1 (2%)                                                                       
      Glandular, Hemorrhage                                         1 (2%)                                                          
      Glandular, Inflammation, Chronic                 1 (2%)                                                                       
      Glandular, Inflammation, Suppurative             3 (6%)                    1 (2%)                                             
      Glandular, Metaplasia, Squamous                               1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Glandular, Mineralization                        5 (10%)      1 (2%)                                                          
      Glandular, Necrosis                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)          (1)                                                 
      Inflammation, Chronic, Multiple                  1 (100%)                                                                     
      Inflammation, Chronic Active, Multiple                        1 (100%)                                                        
      Aorta, Mineralization                                                      1 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Thrombosis                                                    2 (4%)                                                          
      Artery, Mineralization                                        1 (2%)                                                          
      Coronary Artery, Inflammation, Chronic           2 (4%)                                                                       
      Coronary Artery, Media, Hypertrophy              1 (2%)                                                                       
      Endocardium, Inflammation, Chronic Active                                  1 (2%)                                             
      Endocardium, Inflammation, Suppurative                        1 (2%)                                                          
      Myocardium, Angiectasis                          1 (2%)                                                                       
      Myocardium, Fibrosis                             3 (6%)                                                                       
      Myocardium, Inflammation, Chronic                2 (4%)                    1 (2%)                                             
      Myocardium, Inflammation, Chronic Active                      2 (4%)       1 (2%)                                             
      Myocardium, Inflammation, Suppurative            3 (6%)                                                                       
      Myocardium, Mineralization                                                 1 (2%)                                             
      Pericardium, Inflammation, Chronic Active                     1 (2%)                                                          
      Pericardium, Inflammation, Suppurative           1 (2%)                                                                       
      Valve, Inflammation, Suppurative                              1 (2%)                                                          
      Ventricle, Embolus Bacterial                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)                                                          
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Degeneration, Fatty                      4 (8%)       2 (4%)       2 (4%)                                             
      Cortex, Developmental Malformation               1 (2%)       3 (6%)                                                          
      Cortex, Hyperplasia, Focal                       1 (2%)       1 (2%)                                                          
      Cortex, Necrosis                                              1 (2%)       1 (2%)                                             
      Cortex, Vacuolization Cytoplasmic                             1 (2%)                                                          
      Medulla, Angiectasis                                                       1 (2%)                                             
      Medulla, Vacuolization Cytoplasmic               1 (2%)                                                                       
      Spindle Cell, Hyperplasia                       40 (80%)     43 (88%)     48 (96%)                                            
   Islets, Pancreatic                                 (46)         (49)         (49)                                                
      Hyperplasia                                                                7 (14%)                                            
   Parathyroid Gland                                  (46)         (43)         (41)                                                
      Cyst                                             3 (7%)       3 (7%)                                                          
      Ectopic Thymus                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (45)         (45)         (44)                                                
      Angiectasis                                      1 (2%)       2 (4%)       6 (14%)                                            
      Pars Distalis, Angiectasis                       2 (4%)                    2 (5%)                                             
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                      13 (29%)     11 (24%)     13 (30%)                                            
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (49)         (48)         (50)                                                
      Infiltration Cellular, Lymphocyte                2 (4%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Ultimobranchial Cyst                                          1 (2%)                                                          
      Follicle, Dilatation                             6 (12%)      8 (17%)      8 (16%)                                            
      Follicle, Hyperplasia                                                      1 (2%)                                             
      Follicular Cell, Hyperplasia                     5 (10%)      6 (13%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (7)          (2)                                                              
      Foreign Body                                     6 (86%)      2 (100%)                                                        
      Hemorrhage                                                    1 (50%)                                                         
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Inflammation, Suppurative                        6 (86%)      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (46)         (47)         (49)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Angiectasis                                                                2 (4%)                                             
      Cyst                                            18 (39%)     16 (34%)     19 (39%)                                            
      Hemorrhage                                       3 (7%)       1 (2%)       7 (14%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                        7 (15%)      5 (11%)      2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
   Oviduct                                            (1)          (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
   Uterus                                             (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hydrometra                                       1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Cystic                             40 (80%)     41 (82%)     45 (90%)                                            
      Hyperplasia, Cystic, Multiple                    1 (2%)                                                                       
      Hyperplasia, Glandular                           1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Inflammation, Suppurative                        8 (16%)     13 (26%)      7 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Edema                                            1 (2%)                                                          
      Endometrium, Vacuolization Cytoplasmic                                     1 (2%)                                             
      Mucosa, Metaplasia, Squamous                                  1 (2%)       2 (4%)                                             
   Vagina                                             (1)                       (1)                                                 
      Hyperplasia, Squamous                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                     14 (28%)     10 (20%)      2 (4%)                                             
      Hyperplasia, Reticulum Cell                      1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (48)         (49)         (49)                                                
      Bronchial, Inflammation, Suppurative                          1 (2%)                                                          
      Iliac, Hematopoietic Cell Proliferation          1 (2%)                                                                       
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)       3 (6%)                                                          
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Lymphatic, Mandibular, Ectasia                   1 (2%)                                                                       
      Mandibular, Hyperplasia, Histiocytic                          1 (2%)                                                          
      Mandibular, Hyperplasia, Lymphoid                1 (2%)       2 (4%)       4 (8%)                                             
      Mandibular, Hyperplasia, Plasma Cell             3 (6%)       1 (2%)       1 (2%)                                             
      Mandibular, Necrosis, Diffuse                                              1 (2%)                                             
      Mandibular, Pigmentation                                      2 (4%)       3 (6%)                                             
      Mediastinal, Angiectasis                         1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation    1 (2%)       1 (2%)                                                          
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Hyperplasia, Histiocytic            1 (2%)       1 (2%)       1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                         2 (4%)                                                          
      Mediastinal, Inflammation, Suppurative                        1 (2%)                                                          
      Mesenteric, Angiectasis                          1 (2%)                    1 (2%)                                             
      Mesenteric, Atrophy                              1 (2%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation     3 (6%)       2 (4%)       1 (2%)                                             
      Mesenteric, Hemorrhage                           7 (15%)      5 (10%)      4 (8%)                                             
      Mesenteric, Hyperplasia, Histiocytic             1 (2%)       1 (2%)       2 (4%)                                             
      Mesenteric, Hyperplasia, Lymphoid                2 (4%)       3 (6%)                                                          
      Mesenteric, Hyperplasia, Plasma Cell             1 (2%)       1 (2%)                                                          
      Mesenteric, Infiltration Cellular,                                                                                            
          Polymorphonuclear                            1 (2%)                                                                       
      Mesenteric, Inflammation, Granulomatous          1 (2%)                                                                       
      Mesenteric, Lymphatic, Ectasia                   1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                                          2 (4%)                                             
      Pancreatic, Necrosis                                                       1 (2%)                                             
      Renal, Hematopoietic Cell Proliferation          1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                     1 (2%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hyperplasia, Plasma Cell                  4 (8%)       1 (2%)       1 (2%)                                             
      Renal, Inflammation, Suppurative                 1 (2%)                                                                       
   Spleen                                             (48)         (49)         (50)                                                
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation Granulocytic    8 (17%)      8 (16%)      2 (4%)                                             
      Hematopoietic Cell Proliferation Erythrocytic    9 (19%)      8 (16%)      7 (14%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            4 (8%)       4 (8%)       7 (14%)                                            
      Hyperplasia, Megakaryocyte                                    1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Red Pulp, Pigmentation                                                     1 (2%)                                             
   Thymus                                             (41)         (43)         (45)                                                
      Atrophy                                          2 (5%)       4 (9%)       2 (4%)                                             
      Cyst                                             2 (5%)                    3 (7%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis, Diffuse                                2 (5%)                                                                       
      Medulla, Hyperplasia, Mononuclear Cell           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (48)         (49)                                                
      Hyperplasia, Cystic                             12 (25%)      7 (15%)      9 (18%)                                            
      Hyperplasia, Lobular                             1 (2%)                                                                       
   Skin                                               (50)         (49)         (50)                                                
      Acanthosis                                       1 (2%)       2 (4%)       3 (6%)                                             
      Exudate                                                                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hyperostosis                                    15 (30%)     15 (30%)     14 (28%)                                            
      Necrosis                                         1 (2%)                                                                       
      Cranium, Hyperostosis                            1 (2%)                                                                       
   Skeletal Muscle                                    (4)          (2)          (1)                                                 
      Inflammation, Chronic                            1 (25%)                                                                      
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Mineralization                                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebellum, Degeneration, Multifocal                                       1 (2%)                                             
      Cerebellum, Hemorrhage                           1 (2%)       1 (2%)       1 (2%)                                             
      Cerebellum, Infiltration Cellular, Lymphocyte    2 (4%)                                                                       
      Cerebrum, Hemorrhage                             1 (2%)       1 (2%)                                                          
      Cerebrum, Infiltration Cellular, Lymphocyte      1 (2%)                                                                       
      Hippocampus, Necrosis                                                      1 (2%)                                             
      Meninges, Infiltration Cellular, Lymphocyte                                2 (4%)                                             
      Meninges, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                                      1 (2%)                                             
      Thalamus, Degeneration                                                     1 (2%)                                             
      Thalamus, Hemorrhage                             1 (2%)                    1 (2%)                                             
      Thalamus, Infiltration Cellular, Lymphocyte      1 (2%)                                                                       
      Thalamus, Mineralization                        24 (48%)     25 (50%)     18 (36%)                                            
      Vein, Adventitia, Infiltration Cellular,                                                                                      
           Lymphocyte                                  1 (2%)       1 (2%)                                                          
      Ventricle, Hydrocephalus                                                   1 (2%)                                             
      Ventricle, Mineralization                                     1 (2%)                                                          
   Peripheral Nerve                                   (41)         (49)         (45)                                                
      Degeneration                                                  1 (2%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                                               1 (2%)                                             
      Bacterium                                                     1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                2 (4%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic                           24 (48%)     17 (34%)     19 (38%)                                            
      Inflammation, Suppurative                        2 (4%)       1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Artery, Inflammation, Suppurative                             1 (2%)                                                          
      Artery, Mineralization                                                     1 (2%)                                             
      Interstitium, Edema                              3 (6%)                    2 (4%)                                             
      Pleura, Inflammation, Chronic                                 1 (2%)                                                          
      Pleura, Inflammation, Chronic Active                          1 (2%)                                                          
      Pleura, Inflammation, Suppurative                8 (16%)      2 (4%)                                                          
   Nose                                               (43)         (44)         (47)                                                
      Foreign Body                                     1 (2%)       4 (9%)       2 (4%)                                             
      Fungus                                                        1 (2%)       1 (2%)                                             
      Hemorrhage                                                                 3 (6%)                                             
      Inflammation, Chronic                            4 (9%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active                     3 (7%)                                                                       
      Inflammation, Suppurative                       26 (60%)     29 (66%)     33 (70%)                                            
      Mucosa, Atrophy                                               1 (2%)                                                          
      Mucosa, Necrosis                                              1 (2%)                                                          
      Submucosa, Hyperplasia, Lymphoid                                           2 (4%)                                             
   Trachea                                            (49)         (49)         (49)                                                
      Foreign Body                                     2 (4%)                                                                       
      Glands, Inflammation, Suppurative                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)                                                 
      Middle Ear, Inflammation, Suppurative                                      2 (100%)                                           
   Harderian Gland                                    (3)          (3)          (3)                                                 
      Infiltration Cellular, Lymphocyte                1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Casts                                           12 (24%)     10 (20%)      7 (14%)                                            
      Cyst                                             1 (2%)       2 (4%)                                                          
      Glomerulosclerosis                               1 (2%)       2 (4%)                                                          
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                           30 (61%)     24 (48%)     26 (52%)                                            
      Inflammation, Suppurative                        1 (2%)       2 (4%)       1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)       3 (6%)       1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Artery, Media, Hypertrophy                       1 (2%)                                                                       
      Glomerulus, Inflammation, Chronic Active                      1 (2%)                                                          
      Renal Tubule, Atrophy                            3 (6%)       1 (2%)       5 (10%)                                            
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Mineralization                                  2 (4%)                                                          
      Renal Tubule, Regeneration                       8 (16%)      5 (10%)      6 (12%)                                            
   Urinary Bladder                                    (44)         (45)         (49)                                                
      Edema                                            1 (2%)                                                                       
      Inflammation, Chronic                           19 (43%)     13 (29%)     13 (27%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            6            8                                                  
    Moribund                                           5           17           13                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           27           29                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (40)         (35)         (37)                                                
      Amyloid Deposition                                            1 (3%)                                                          
      Concretion                                       2 (5%)                                                                       
      Hemorrhage                                       1 (3%)                                                                       
      Inflammation, Suppurative                        1 (3%)       1 (3%)                                                          
   Intestine Large                                    (49)         (50)         (49)                                                
      Cecum, Hyperplasia, Lymphoid                     2 (4%)                                                                       
      Cecum, Mucosa, Fibrosis                          1 (2%)                                                                       
      Cecum, Serosa, Ectopic Tissue                                              1 (2%)                                             
   Intestine Small                                    (48)         (50)         (49)                                                
      Duodenum, Ulcer                                               1 (2%)                                                          
      Ileum, Peyer's Patch, Hyperplasia, Lymphoid      3 (6%)       2 (4%)       3 (6%)                                             
      Mucosa, Ileum, Dysplasia                         1 (2%)                                                                       
      Serosa, Jejunum, Cyst                                         1 (2%)                                                          
      Serosa, Jejunum, Inflammation, Granulomatous                  1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                                                1 (2%)                                             
      Clear Cell Focus                                 2 (4%)       1 (2%)       2 (4%)                                             
      Eosinophilic Focus                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       3 (6%)       4 (8%)                                             
      Hyperplasia, Focal                                                         1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       3 (6%)       5 (10%)                                            
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
      Bile Duct, Cyst                                               1 (2%)                                                          
      Hepatocyte, Anisokaryosis                        1 (2%)                                                                       
      Hepatocyte, Cytomegaly                           2 (4%)                                                                       
      Hepatocyte, Cytoplasmic Alteration                            2 (4%)                                                          
      Hepatocyte, Karyomegaly                          3 (6%)       2 (4%)       2 (4%)                                             
      Hepatocyte, Necrosis                             3 (6%)       4 (8%)       3 (6%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)      6 (12%)     10 (20%)                                            
      Kupffer Cell, Hyperplasia                        3 (6%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Pigmentation                       3 (6%)                    1 (2%)                                             
      Vein, Thrombosis                                                           1 (2%)                                             
      Vein, Adventitia, Fibrosis                                                 1 (2%)                                             
   Mesentery                                          (5)          (6)          (8)                                                 
      Fibrosis                                                                   1 (13%)                                            
      Hemorrhage                                                    1 (17%)                                                         
      Inflammation, Suppurative                        1 (20%)                                                                      
      Mineralization                                                1 (17%)      1 (13%)                                            
      Artery, Inflammation, Chronic                                              1 (13%)                                            
      Artery, Necrosis                                              1 (17%)                                                         
      Artery, Thrombosis                                            1 (17%)                                                         
      Fat, Necrosis, Focal                             1 (20%)      3 (50%)      3 (38%)                                            
   Pancreas                                           (50)         (48)         (48)                                                
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Atypia Cellular, Focal                           1 (2%)                                                                       
      Cyst                                                          2 (4%)                                                          
      Hyperplasia, Focal                                            1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       2 (4%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
      Inflammation, Chronic                           13 (26%)      8 (16%)      8 (16%)                                            
   Stomach                                            (50)         (50)         (50)                                                
      Forestomach, Cyst                                1 (2%)                                                                       
      Forestomach, Hyperplasia                        10 (20%)      5 (10%)      9 (18%)                                            
      Forestomach, Inflammation, Chronic               3 (6%)       1 (2%)       1 (2%)                                             
      Forestomach, Inflammation, Chronic Active        4 (8%)       2 (4%)       2 (4%)                                             
      Forestomach, Inflammation, Suppurative                        1 (2%)                                                          
      Forestomach, Mineralization                      1 (2%)       1 (2%)                                                          
      Forestomach, Ulcer                               2 (4%)                                                                       
      Forestomach, Mucosa, Hyperplasia                 1 (2%)                                                                       
      Glandular, Cyst                                  1 (2%)                    1 (2%)                                             
      Glandular, Dysplasia                             2 (4%)                                                                       
      Glandular, Erosion                                            2 (4%)                                                          
      Glandular, Inflammation, Chronic Active          1 (2%)                                                                       
      Glandular, Inflammation, Suppurative             3 (6%)       2 (4%)                                                          
      Glandular, Metaplasia, Squamous                  1 (2%)                                                                       
      Glandular, Mineralization                        2 (4%)       3 (6%)       3 (6%)                                             
   Tooth                                              (7)          (10)         (4)                                                 
      Developmental Malformation                       4 (57%)     10 (100%)     3 (75%)                                            
      Foreign Body                                                  1 (10%)                                                         
      Peridontal Tissue, Fibrosis                      1 (14%)                                                                      
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       2 (29%)      1 (10%)                                                         
      Peridontal Tissue, Inflammation, Suppurative     1 (14%)      2 (20%)                                                         
      Pulp, Inflammation, Suppurative                               2 (20%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (1)                                                 
      Inflammation, Chronic Active                     1 (33%)                   1 (100%)                                           
      Aorta, Embolus Bacterial                         2 (67%)                                                                      
      Aorta, Inflammation, Chronic Active              1 (33%)                                                                      
   Heart                                              (50)         (50)         (50)                                                
      Embolus Bacterial                                1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic                        2 (4%)       1 (2%)                                             
      Coronary Artery, Inflammation, Chronic Active                              1 (2%)                                             
      Coronary Artery, Inflammation, Suppurative       1 (2%)                                                                       
      Coronary Artery, Necrosis, Fibrinoid             1 (2%)                                                                       
      Endocardium, Inflammation, Chronic               1 (2%)                                                                       
      Epicardium, Fibrosis                             1 (2%)                                                                       
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
      Myocardium, Fibrosis                             1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                1 (2%)       2 (4%)                                                          
      Myocardium, Inflammation, Suppurative            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (50)         (49)                                                
      Developmental Malformation                       1 (2%)       1 (2%)       2 (4%)                                             
      Cortex, Atrophy                                                            1 (2%)                                             
      Cortex, Hyperplasia                              1 (2%)                                                                       
      Cortex, Hyperplasia, Focal                       2 (4%)       4 (8%)       1 (2%)                                             
      Cortex, Infiltration Cellular, Lymphocyte        1 (2%)                                                                       
      Cortex, Vacuolization Cytoplasmic                             2 (4%)                                                          
      Medulla, Hyperplasia                             2 (4%)       1 (2%)       2 (4%)                                             
      Spindle Cell, Hyperplasia                       27 (56%)     27 (54%)     21 (43%)                                            
   Islets, Pancreatic                                 (50)         (47)         (48)                                                
      Dysplasia                                        1 (2%)                                                                       
      Hyperplasia                                     15 (30%)     13 (28%)      7 (15%)                                            
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Parathyroid Gland                                  (28)         (40)         (43)                                                
      Crystals                                                                   1 (2%)                                             
      Cyst                                                          1 (3%)       2 (5%)                                             
      Infiltration Cellular, Lymphocyte                1 (4%)                    1 (2%)                                             
   Pituitary Gland                                    (40)         (44)         (40)                                                
      Pars Distalis, Cyst                              3 (8%)       4 (9%)                                                          
      Pars Distalis, Hyperplasia                                    2 (5%)       1 (3%)                                             
   Thyroid Gland                                      (45)         (50)         (49)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Follicle, Crystals                               1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Dilatation                             5 (11%)      3 (6%)       3 (6%)                                             
      Follicular Cell, Hyperplasia                     4 (9%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)          (1)                                                 
      Foreign Body                                     1 (50%)                                                                      
      Hemorrhage                                       1 (50%)      1 (50%)                                                         
      Inflammation, Suppurative                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)                       (1)                                                 
      Dilatation                                       1 (50%)                   1 (100%)                                           
   Epididymis                                         (50)         (49)         (49)                                                
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Preputial Gland                                    (20)         (14)         (11)                                                
      Ectasia                                         14 (70%)     12 (86%)      5 (45%)                                            
      Inflammation, Chronic                           10 (50%)      6 (43%)      7 (64%)                                            
      Inflammation, Chronic Active                     1 (5%)                                                                       
      Inflammation, Suppurative                        9 (45%)      3 (21%)      5 (45%)                                            
   Prostate                                           (47)         (49)         (49)                                                
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic                            7 (15%)      4 (8%)       2 (4%)                                             
      Inflammation, Suppurative                        4 (9%)       3 (6%)       1 (2%)                                             
   Seminal Vesicle                                    (5)          (5)          (5)                                                 
      Amyloid Deposition                               1 (20%)                                                                      
      Dilatation                                       1 (20%)                   1 (20%)                                            
      Fibrosis                                         2 (40%)      1 (20%)      2 (40%)                                            
      Inflammation, Chronic                            1 (20%)                   1 (20%)                                            
      Inflammation, Chronic Active                                               1 (20%)                                            
      Inflammation, Suppurative                        2 (40%)      3 (60%)                                                         
      Pigmentation                                                  1 (20%)                                                         
   Testes                                             (50)         (50)         (49)                                                
      Artery, Mineralization                           1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     3 (6%)       7 (14%)      2 (4%)                                             
      Seminiferous Tubule, Mineralization              4 (8%)       4 (8%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Hyperplasia                                      9 (18%)      7 (14%)     10 (20%)                                            
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
   Lymph Node                                         (47)         (48)         (50)                                                
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Inguinal, Fibrosis                               1 (2%)                                                                       
      Inguinal, Hyperplasia, Histiocytic               2 (4%)       1 (2%)       2 (4%)                                             
      Inguinal, Hyperplasia, Plasma Cell                            1 (2%)       2 (4%)                                             
      Inguinal, Infiltration Cellular,                                                                                              
          Polymorphonuclear                                         1 (2%)                                                          
      Inguinal, Pigmentation                                        4 (8%)       4 (8%)                                             
      Lymphatic, Mandibular, Ectasia                                             1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)       1 (2%)                                             
      Mandibular, Hyperplasia, Plasma Cell             1 (2%)       2 (4%)       5 (10%)                                            
      Mandibular, Pigmentation                                      2 (4%)                                                          
      Mesenteric, Angiectasis                                       2 (4%)       1 (2%)                                             
      Mesenteric, Atrophy                              1 (2%)       1 (2%)       1 (2%)                                             
      Mesenteric, Congestion                                                     1 (2%)                                             
      Mesenteric, Hematopoietic Cell Proliferation     4 (9%)       6 (13%)      4 (8%)                                             
      Mesenteric, Hemorrhage                          19 (40%)     14 (29%)     14 (28%)                                            
      Mesenteric, Hyperplasia, Histiocytic             1 (2%)                    1 (2%)                                             
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                    3 (6%)                                             
      Mesenteric, Hyperplasia, Plasma Cell                          1 (2%)       1 (2%)                                             
      Mesenteric, Infiltration Cellular, Mast Cell                               1 (2%)                                             
      Mesenteric, Infiltration Cellular,                                                                                            
          Megakaryocyte                                                          1 (2%)                                             
      Mesenteric, Infiltration Cellular,                                                                                            
          Polymorphonuclear                                         1 (2%)                                                          
      Mesenteric, Lymphatic, Ectasia                                2 (4%)                                                          
      Renal, Hemorrhage                                             1 (2%)                                                          
      Renal, Hyperplasia, Histiocytic                                            1 (2%)                                             
      Renal, Hyperplasia, Plasma Cell                               1 (2%)                                                          
      Renal, Lymphatic, Ectasia                                     1 (2%)                                                          
   Spleen                                             (49)         (49)         (49)                                                
      Hematopoietic Cell Proliferation Granulocytic    2 (4%)       4 (8%)       5 (10%)                                            
      Hematopoietic Cell Proliferation Erythrocytic   10 (20%)     10 (20%)      9 (18%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       3 (6%)       1 (2%)                                             
      Hyperplasia, Megakaryocyte                                    1 (2%)                                                          
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Lymphoid Follicle, Atrophy                                    1 (2%)                                                          
   Thymus                                             (35)         (32)         (36)                                                
      Atrophy                                                       1 (3%)                                                          
      Cyst                                             3 (9%)       7 (22%)      7 (19%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)                                                
      Acanthosis                                      12 (24%)     16 (33%)     17 (34%)                                            
      Acanthosis, Multiple                                          1 (2%)                                                          
      Edema                                                         3 (6%)       1 (2%)                                             
      Erosion                                                                    2 (4%)                                             
      Exudate                                          1 (2%)       1 (2%)       2 (4%)                                             
      Fibrosis                                         3 (6%)       3 (6%)       1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Fungus                                                        1 (2%)       1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       7 (14%)      7 (14%)                                            
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic Active, Multiple           1 (2%)                                                                       
      Inflammation, Granulomatous                                   2 (4%)       2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       3 (6%)       1 (2%)                                             
      Ulcer                                            1 (2%)       2 (4%)       6 (12%)                                            
      Lymphatic, Angiectasis                                        1 (2%)                                                          
      Sebaceous Gland, Hyperplasia                                               1 (2%)                                             
      Subcutaneous Tissue, Fibrosis                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (47)                                                
      Dysplasia                                                     2 (4%)                                                          
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Proliferation                                    1 (2%)                                                                       
   Skeletal Muscle                                    (5)          (1)          (4)                                                 
      Foreign Body                                                               1 (25%)                                            
      Hemorrhage                                                                 1 (25%)                                            
      Inflammation, Chronic                            2 (40%)      1 (100%)     1 (25%)                                            
      Inflammation, Chronic Active                     1 (20%)                                                                      
      Inflammation, Granulomatous                                                1 (25%)                                            
      Inflammation, Suppurative                        2 (40%)                   1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebrum, Vacuolization Cytoplasmic                                        1 (2%)                                             
      Hippocampus, Infiltration Cellular,                                                                                           
          Lymphocyte                                                             1 (2%)                                             
      Thalamus, Mineralization                        20 (40%)     26 (52%)     25 (50%)                                            
      Venule, Infiltration Cellular, Lymphocyte        1 (2%)                                                                       
   Peripheral Nerve                                   (40)         (50)         (42)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Degeneration                                                  1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (3%)                    2 (5%)                                             
      Inflammation, Subacute                           4 (10%)                   2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Hemorrhage                                                    1 (2%)       3 (6%)                                             
      Infiltration Cellular, Eosinophil                                          1 (2%)                                             
      Infiltration Cellular, Histiocyte                3 (6%)       8 (16%)      5 (10%)                                            
      Inflammation, Chronic                           27 (54%)     10 (20%)     17 (34%)                                            
      Inflammation, Suppurative                        1 (2%)       2 (4%)       9 (18%)                                            
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       4 (8%)                                                          
      Artery, Mineralization                           1 (2%)                                                                       
      Bronchus, Foreign Body                                                     1 (2%)                                             
      Capillary, Infiltration Cellular,                                                                                             
          Polymorphonuclear                                                      1 (2%)                                             
      Glands, Ectasia                                               1 (2%)                                                          
      Interstitium, Edema                              4 (8%)       4 (8%)       3 (6%)                                             
      Pleura, Inflammation, Suppurative                1 (2%)                                                                       
   Nose                                               (46)         (50)         (48)                                                
      Fungus                                                                     2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                       16 (35%)      5 (10%)     16 (33%)                                            
      Glands, Cyst                                                  1 (2%)                                                          
      Mucosa, Metaplasia, Squamous                                               1 (2%)                                             
   Trachea                                            (49)         (50)         (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Submucosa, Cyst                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Hyperplasia                                                        1 (100%)                                           
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
   Harderian Gland                                    (6)          (3)          (8)                                                 
      Cyst                                                                       1 (13%)                                            
      Inflammation, Chronic                            1 (17%)                   1 (13%)                                            
   Lacrimal Gland                                     (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05049-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Amyloid Deposition                               1 (2%)                                                                       
      Bacterium                                        1 (2%)                    1 (2%)                                             
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Casts                                            5 (10%)     11 (22%)      5 (10%)                                            
      Congestion                                                    1 (2%)                                                          
      Cyst                                             3 (6%)       8 (16%)      2 (4%)                                             
      Glomerulosclerosis                                            4 (8%)       3 (6%)                                             
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           29 (58%)     27 (54%)     26 (52%)                                            
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                        3 (6%)       2 (4%)       3 (6%)                                             
      Metaplasia, Osseous                              1 (2%)       2 (4%)                                                          
      Cortex, Necrosis                                                           1 (2%)                                             
      Renal Tubule, Atrophy                            2 (4%)       4 (8%)       4 (8%)                                             
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Dilatation                         2 (4%)                                                                       
      Renal Tubule, Mineralization                     2 (4%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Regeneration                      26 (52%)     24 (48%)     22 (44%)                                            
      Renal Tubule, Vacuolization Cytoplasmic          1 (2%)                                                                       
   Urethra                                            (2)                                                                           
      Angiectasis                                      1 (50%)                                                                      
      Inflammation, Chronic Active                     1 (50%)                                                                      
      Inflammation, Suppurative                        1 (50%)                                                                      
   Urinary Bladder                                    (50)         (48)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Calculus Gross Observation                       1 (2%)                                                                       
      Calculus Micro Observation Only                                            2 (4%)                                             
      Edema                                                         1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Mucosa, Hyperplasia                              2 (4%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
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