National Toxicology Program

National Toxicology Program
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TDMS Study 05049-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             DICHLORVOS


NTP Experiment-Test: 05049-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: GAVAGE                                                                                                     Time: 05:40:06




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15            5            9                                                  
    Accident                                           6            5            2                                                  
    Dead                                               3           11            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           29           34                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (49)         (50)         (50)                                                
   Intestine Small                                    (46)         (49)         (48)                                                
      Jejunum, Fibrous Histiocytoma                    1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         4 (8%)       3 (6%)       3 (6%)                                             
      Hepatocellular Adenoma                           2 (4%)       1 (2%)       4 (8%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Mesentery                                          (13)         (10)         (7)                                                 
      Fibrous Histiocytoma, Multiple                   1 (8%)                                                                       
   Pancreas                                           (47)         (49)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)                                                
   Stomach                                            (49)         (49)         (50)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Forestomach, Squamous Cell Carcinoma                                       2 (4%)                                             
      Forestomach, Squamous Cell Papilloma             5 (10%)      6 (12%)     18 (36%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Medulla, Pheochromocytoma Benign                 4 (8%)       1 (2%)                                                          
   Islets, Pancreatic                                 (46)         (49)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (45)         (45)         (44)                                                
      Pars Distalis, Adenoma                          11 (24%)      6 (13%)      6 (14%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                         2 (4%)       1 (2%)                                                          
   Thyroid Gland                                      (49)         (48)         (50)                                                
      Follicular Cell, Adenocarcinoma                  1 (2%)                                                                       
      Follicular Cell, Adenoma                         3 (6%)       4 (8%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (7)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (46)         (47)         (49)                                                
      Cystadenoma                                      2 (4%)                                                                       
   Oviduct                                            (1)          (1)                                                              
   Uterus                                             (50)         (50)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    2 (4%)                                                                       
      Sarcoma Stromal                                  1 (2%)                    1 (2%)                                             
   Vagina                                             (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
   Lymph Node                                         (48)         (49)         (49)                                                
      Adenocarcinoma, Metastatic, Thyroid Gland        1 (2%)                                                                       
   Spleen                                             (48)         (49)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (41)         (43)         (45)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (48)         (49)                                                
      Adenocarcinoma                                   2 (4%)                                                                       
   Skin                                               (50)         (49)         (50)                                                
      Sebaceous Gland, Adenoma                                                   2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Osteosarcoma                                                  1 (2%)       1 (2%)                                             
   Skeletal Muscle                                    (4)          (2)          (1)                                                 
      Fibrous Histiocytoma                             1 (25%)                                                                      
      Hemangiosarcoma                                  1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Meningioma Benign                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       3 (6%)       5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)       1 (2%)                                             
   Nose                                               (43)         (44)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (3)                                                 
      Adenoma                                          1 (33%)      3 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
   Ureter                                                                       (1)                                                 
   Urinary Bladder                                    (44)         (45)         (49)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   2 (4%)                    2 (4%)                                             
      Lymphoma Malignant Lymphocytic                   5 (10%)      2 (4%)                                                          
      Lymphoma Malignant Mixed                         8 (16%)      9 (18%)      7 (14%)                                            
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      20.0         40.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          26          37                                                   
     Total Primary Neoplasms                           73          40          68                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          17          32                                                   
     Total Benign Neoplasms                            34          25          43                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          15          18                                                   
     Total Malignant Neoplasms                         39          15          25                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           1           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            6            8                                                  
    Moribund                                           5           17           13                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           27           29                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (49)         (50)         (49)                                                
      Cecum, Carcinoma                                 1 (2%)                                                                       
   Intestine Small                                    (48)         (50)         (49)                                                
      Duodenum, Adenocarcinoma                         1 (2%)       1 (2%)       1 (2%)                                             
      Duodenum, Polyp Adenomatous                                                1 (2%)                                             
      Jejunum, Adenocarcinoma                                       1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Multiple                                     2 (4%)                                                          
      Hepatocellular Carcinoma                         7 (14%)     13 (26%)      8 (16%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       3 (6%)       2 (4%)                                             
      Hepatocellular Adenoma                           5 (10%)      3 (6%)       8 (16%)                                            
      Hepatocellular Adenoma, Multiple                 2 (4%)                    3 (6%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (2%)                                             
   Mesentery                                          (5)          (6)          (8)                                                 
      Hemangioma                                       1 (20%)                                                                      
      Hemangiosarcoma                                               1 (17%)                                                         
   Pancreas                                           (50)         (48)         (48)                                                
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach                                            (50)         (50)         (50)                                                
      Forestomach, Squamous Cell Papilloma                          1 (2%)       5 (10%)                                            
      Forestomach, Squamous Cell Papilloma,                                                                                         
          Multiple                                     1 (2%)                                                                       
      Glandular, Carcinoid Tumor Malignant                                       1 (2%)                                             
   Tooth                                              (7)          (10)         (4)                                                 
      Neoplasm NOS                                                               1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (50)         (49)                                                
      Cortex, Adenoma                                               1 (2%)                                                          
      Medulla, Pheochromocytoma Malignant                                        1 (2%)                                             
      Medulla, Pheochromocytoma Benign                 2 (4%)       5 (10%)      1 (2%)                                             
   Islets, Pancreatic                                 (50)         (47)         (48)                                                
   Pituitary Gland                                    (40)         (44)         (40)                                                
      Pars Distalis, Adenoma                                        1 (2%)       1 (3%)                                             
   Thyroid Gland                                      (45)         (50)         (49)                                                
      Follicular Cell, Adenoma                                      3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (49)                                                
   Preputial Gland                                    (20)         (14)         (11)                                                
      Hemangiosarcoma                                  1 (5%)                                                                       
   Testes                                             (50)         (50)         (49)                                                
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                               2 (4%)                                                          
   Lymph Node                                         (47)         (48)         (50)                                                
      Mandibular, Sarcoma                                           1 (2%)       1 (2%)                                             
   Spleen                                             (49)         (49)         (49)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
   Thymus                                             (35)         (32)         (36)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)         (50)                                                
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Keratoacanthoma, Multiple                                                  1 (2%)                                             
      Papilloma                                                                  1 (2%)                                             
      Plasma Cell Tumor Malignant                      1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)                    2 (4%)                                             
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       4 (8%)       4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      4 (8%)       4 (8%)       3 (6%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Sarcoma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant,                                                                                    
           Multiple                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     9 (18%)     13 (26%)      8 (16%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic             1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       1 (2%)       3 (6%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Nose                                               (46)         (50)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (3)          (8)                                                 
      Adenoma                                          5 (83%)      3 (100%)     5 (63%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Sarcoma                                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         6 (12%)                   3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05049-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 05:40:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      10.0         20.0                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          41          37                                                   
     Total Primary Neoplasms                           60          77          68                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          26          28                                                   
     Total Benign Neoplasms                            30          32          38                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          31          23                                                   
     Total Malignant Neoplasms                         30          45          29                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           4                                                   
     Total Metastatic Neoplasm                          4           1           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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