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TDMS Study 05049-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                    DICHLORVOS                                      DATE: 09/07/94       
EXPERIMENT: 05049 TEST: 02                                                                                     TIME: 05:49:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 00113B       
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 62-73-7         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                    DICHLORVOS                                      DATE: 09/07/94      
EXPERIMENT: 05049 TEST: 02                                                                                     TIME: 05:49:49      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 00113B      
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 62-73-7        
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                    DICHLORVOS                                      DATE: 09/07/94       
EXPERIMENT: 05049 TEST: 02                                                                                     TIME: 05:49:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-28024          ROUTE: GAVAGE                                                                      NTP C#: 00113B       
PATHOLOGIST: J. HEATH                        S. EUSTIS                                                         CAS: 62-73-7         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                           IN THE ANALYSIS OF THE STUDY OF DICHLORVOS
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Skin: Subcutaneous Tissue     Fibroma
                             Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
                                                           Squamous Cell Papilloma
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
                                                           Squamous Cell Papilloma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   1
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/48 (4%)       5/50 (10%)      1/49 (2%)      |     4/50 (8%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      6.1%           12.7%            2.4%          |     14.8%            3.4%            0.0%          |
|TERMINAL (d)           |     2/33 (6%)       1/27 (4%)       0/29 (0%)      |     3/26 (12%)      1/29 (3%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         559             578           |      724             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.445N        P=0.201         P=0.527N       |     P=0.014N*       P=0.151N        P=0.036N*      |
|INCIDENTAL TUMOR       |     P=0.234N        P=0.395         P=0.425N       |     P=0.018N*       P=0.170N        P=0.045N*      |
|LOGISTIC REGRESSION    |     P=0.405N        P=0.226         P=0.492N       |     P=0.015N*       P=0.158N        P=0.036N*      |
|COCHRAN-ARMITAGE       |     P=0.402N                                       |     P=0.026N*                                      |
|FISHER EXACT           |                     P=0.235         P=0.492N       |                     P=0.187N        P=0.059N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/48 (4%)       5/50 (10%)      2/49 (4%)      |     4/50 (8%)       1/49 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      6.1%           12.7%            5.7%          |     14.8%            3.4%            0.0%          |
|TERMINAL (d)           |     2/33 (6%)       1/27 (4%)       1/29 (3%)      |     3/26 (12%)      1/29 (3%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         559             578           |      724             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.545         P=0.201         P=0.661        |     P=0.014N*       P=0.151N        P=0.036N*      |
|INCIDENTAL TUMOR       |     P=0.418N        P=0.395         P=0.652N       |     P=0.018N*       P=0.170N        P=0.045N*      |
|LOGISTIC REGRESSION    |     P=0.574N        P=0.226         P=0.691N       |     P=0.015N*       P=0.158N        P=0.036N*      |
|COCHRAN-ARMITAGE       |     P=0.574N                                       |     P=0.026N*                                      |
|FISHER EXACT           |                     P=0.235         P=0.684N       |                     P=0.187N        P=0.059N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   2
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            5.4%            0.0%          |      3.8%            0.0%            2.1%          |
|TERMINAL (d)           |     0/35 (0%)       0/27 (0%)       0/29 (0%)      |     1/26 (4%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             624             ---           |      729 (T)         ---             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.638         P=0.236           (e)          |     P=0.626N        P=0.478N        P=0.718N       |
|INCIDENTAL TUMOR       |     P=0.592N        P=0.500           (e)          |     P=0.591N        P=0.478N        P=0.684N       |
|LOGISTIC REGRESSION    |     P=0.667         P=0.225           (e)          |     P=0.668         P=0.478N        P=0.761        |
|COCHRAN-ARMITAGE       |     P=0.669                                        |     P=0.669N                                       |
|FISHER EXACT           |                     P=0.247           (e)          |                     P=0.500N        P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      3/50 (6%)       5/50 (10%)     |     1/50 (2%)       3/50 (6%)       3/50 (6%)      |
|ADJUSTED (b)           |     13.4%            9.8%           14.6%          |      3.8%           10.3%            7.2%          |
|TERMINAL (d)           |     4/35 (11%)      1/27 (4%)       3/29 (10%)     |     1/26 (4%)       3/29 (10%)      1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      541             694             578           |      729 (T)         729 (T)         534           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.483         P=0.464N        P=0.548        |     P=0.329         P=0.344         P=0.385        |
|INCIDENTAL TUMOR       |     P=0.566N        P=0.274N        P=0.602N       |     P=0.299         P=0.344         P=0.328        |
|LOGISTIC REGRESSION    |     P=0.564         P=0.337N        P=0.627        |     P=0.272         P=0.344         P=0.313        |
|COCHRAN-ARMITAGE       |     P=0.571N                                       |     P=0.238                                        |
|FISHER EXACT           |                     P=0.357N        P=0.630N       |                     P=0.309         P=0.309        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   3
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.9%            7.4%            3.4%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/35 (3%)       2/27 (7%)       1/29 (3%)      |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         729 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.557         P=0.409         P=0.720        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.557         P=0.409         P=0.720        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.557         P=0.409         P=0.720        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.753N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.9%            4.5%            0.0%          |      3.8%            0.0%            0.0%          |
|TERMINAL (d)           |     1/35 (3%)       0/27 (0%)       0/29 (0%)      |     1/26 (4%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         514             ---           |      729 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.386N        P=0.486         P=0.538N       |     P=0.235N        P=0.478N        P=0.446N       |
|INCIDENTAL TUMOR       |     P=0.305N        P=0.515         P=0.538N       |     P=0.235N        P=0.478N        P=0.446N       |
|LOGISTIC REGRESSION    |     P=0.368N        P=0.463         P=0.538N       |     P=0.235N        P=0.478N        P=0.446N       |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P=0.269N                                       |
|FISHER EXACT           |                     P=0.500         P=0.500N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   4
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      3/50 (6%)      11/50 (22%)     |     2/50 (4%)       1/50 (2%)       4/50 (8%)      |
|ADJUSTED (b)           |     20.0%           11.1%           36.0%          |      7.2%            3.4%           10.9%          |
|TERMINAL (d)           |     7/35 (20%)      3/27 (11%)     10/29 (34%)     |     1/26 (4%)       1/29 (3%)       3/34 (9%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         578           |      707             729 (T)         624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.080         P=0.277N        P=0.107        |     P=0.337         P=0.475N        P=0.459        |
|INCIDENTAL TUMOR       |     P=0.092         P=0.277N        P=0.128        |     P=0.269         P=0.508N        P=0.357        |
|LOGISTIC REGRESSION    |     P=0.093         P=0.277N        P=0.134        |     P=0.295         P=0.489N        P=0.401        |
|COCHRAN-ARMITAGE       |     P=0.157                                        |     P=0.238                                        |
|FISHER EXACT           |                     P=0.159N        P=0.218        |                     P=0.500N        P=0.339        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    10/50 (20%)     16/50 (32%)     10/50 (20%)     |     4/50 (8%)       3/50 (6%)       3/50 (6%)      |
|ADJUSTED (b)           |     25.9%           40.0%           25.1%          |     12.7%            9.1%            7.5%          |
|TERMINAL (d)           |     7/35 (20%)      6/27 (22%)      3/29 (10%)     |     2/26 (8%)       2/29 (7%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      543             534             505           |      452             551             656           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.420         P=0.087         P=0.491        |     P=0.322N        P=0.463N        P=0.392N       |
|INCIDENTAL TUMOR       |     P=0.295N        P=0.317         P=0.380N       |     P=0.403N        P=0.488N        P=0.468N       |
|LOGISTIC REGRESSION    |     P=0.324N        P=0.137         P=0.598N       |     P=0.396N        P=0.493N        P=0.484N       |
|COCHRAN-ARMITAGE       |     P=0.547                                        |     P=0.421N                                       |
|FISHER EXACT           |                     P=0.127         P=0.598N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   5
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    16/50 (32%)     18/50 (36%)     20/50 (40%)     |     6/50 (12%)      4/50 (8%)       7/50 (14%)     |
|ADJUSTED (b)           |     41.8%           45.8%           52.3%          |     19.2%           12.4%           17.6%          |
|TERMINAL (d)           |    13/35 (37%)      8/27 (30%)     12/29 (41%)     |     3/26 (12%)      3/29 (10%)      3/34 (9%)      |
|FIRST INCIDENCE (DAYS) |      543             534             505           |      452             551             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.128         P=0.245         P=0.141        |     P=0.525N        P=0.330N        P=0.559N       |
|INCIDENTAL TUMOR       |     P=0.359         P=0.587N        P=0.351        |     P=0.477         P=0.366N        P=0.540        |
|LOGISTIC REGRESSION    |     P=0.229         P=0.471         P=0.253        |     P=0.497         P=0.358N        P=0.558        |
|COCHRAN-ARMITAGE       |     P=0.233                                        |     P=0.437                                        |
|FISHER EXACT           |                     P=0.417         P=0.266        |                     P=0.370N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    16/50 (32%)     18/50 (36%)     20/50 (40%)     |     6/50 (12%)      4/50 (8%)       7/50 (14%)     |
|ADJUSTED (b)           |     41.8%           45.8%           52.3%          |     19.2%           12.4%           17.6%          |
|TERMINAL (d)           |    13/35 (37%)      8/27 (30%)     12/29 (41%)     |     3/26 (12%)      3/29 (10%)      3/34 (9%)      |
|FIRST INCIDENCE (DAYS) |      543             534             505           |      452             551             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.128         P=0.245         P=0.141        |     P=0.525N        P=0.330N        P=0.559N       |
|INCIDENTAL TUMOR       |     P=0.359         P=0.587N        P=0.351        |     P=0.477         P=0.366N        P=0.540        |
|LOGISTIC REGRESSION    |     P=0.229         P=0.471         P=0.253        |     P=0.497         P=0.358N        P=0.558        |
|COCHRAN-ARMITAGE       |     P=0.233                                        |     P=0.437                                        |
|FISHER EXACT           |                     P=0.417         P=0.266        |                     P=0.370N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   6
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)     14/50 (28%)      9/50 (18%)     |     1/50 (2%)       3/50 (6%)       5/50 (10%)     |
|ADJUSTED (b)           |     24.7%           44.1%           27.0%          |      3.7%            9.4%           14.7%          |
|TERMINAL (d)           |     8/35 (23%)     10/27 (37%)      6/29 (21%)     |     0/26 (0%)       2/29 (7%)       5/34 (15%)     |
|FIRST INCIDENCE (DAYS) |      543             637             573           |      724             632             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.375         P=0.064         P=0.463        |     P=0.127         P=0.339         P=0.173        |
|INCIDENTAL TUMOR       |     P=0.506         P=0.151         P=0.603N       |     P=0.094         P=0.301         P=0.155        |
|LOGISTIC REGRESSION    |     P=0.492         P=0.171         P=0.573        |     P=0.106         P=0.313         P=0.160        |
|COCHRAN-ARMITAGE       |     P=0.549N                                       |     P=0.070                                        |
|FISHER EXACT           |                     P=0.171         P=0.602N       |                     P=0.309         P=0.102        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       2/50 (4%)      |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      2.6%            6.8%            6.9%          |      6.4%            0.0%            2.9%          |
|TERMINAL (d)           |     0/35 (0%)       1/27 (4%)       2/29 (7%)      |     1/26 (4%)       0/29 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      590             714             729 (T)       |      602             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.336         P=0.465         P=0.447        |     P=0.301N        P=0.231N        P=0.419N       |
|INCIDENTAL TUMOR       |     P=0.404         P=0.712         P=0.562        |     P=0.363N        P=0.228N        P=0.516N       |
|LOGISTIC REGRESSION    |     P=0.377         P=0.509         P=0.497        |     P=0.335N        P=0.234N        P=0.469N       |
|COCHRAN-ARMITAGE       |     P=0.390                                        |     P=0.360N                                       |
|FISHER EXACT           |                     P=0.500         P=0.500        |                     P=0.247N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   7
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    10/50 (20%)     15/50 (30%)     10/50 (20%)     |     3/50 (6%)       3/50 (6%)       6/50 (12%)     |
|ADJUSTED (b)           |     26.6%           45.9%           30.1%          |      9.8%            9.4%           17.6%          |
|TERMINAL (d)           |     8/35 (23%)     10/27 (37%)      7/29 (24%)     |     1/26 (4%)       2/29 (7%)       6/34 (18%)     |
|FIRST INCIDENCE (DAYS) |      543             637             573           |      602             632             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.368         P=0.074         P=0.452        |     P=0.294         P=0.627N        P=0.381        |
|INCIDENTAL TUMOR       |     P=0.527         P=0.224         P=0.564N       |     P=0.213         P=0.659N        P=0.303        |
|LOGISTIC REGRESSION    |     P=0.498         P=0.194         P=0.576        |     P=0.242         P=0.654N        P=0.325        |
|COCHRAN-ARMITAGE       |     P=0.547N                                       |     P=0.178                                        |
|FISHER EXACT           |                     P=0.178         P=0.598N       |                     P=0.661N        P=0.243        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      7.2%            0.0%            0.0%          |
|TERMINAL (d)           |     0/35 (0%)       0/27 (0%)       0/29 (0%)      |     1/26 (4%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      707             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.075N        P=0.228N        P=0.186N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.094N        P=0.258N        P=0.224N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.080N        P=0.231N        P=0.198N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.095N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.247N        P=0.247N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   8
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/46 (4%)       0/47 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |                                                    |      8.0%            0.0%            0.0%          |
|TERMINAL (d)           |                                                    |     2/25 (8%)       0/27 (0%)       0/33 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      729 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.072N        P=0.221N        P=0.179N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.072N        P=0.221N        P=0.179N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.072N        P=0.221N        P=0.179N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.090N                                       |
|FISHER EXACT           |                                                    |                     P=0.242N        P=0.232N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/40 (0%)       1/44 (2%)       1/40 (3%)      |    11/45 (24%)      6/45 (13%)      6/44 (14%)     |
|ADJUSTED (b)           |      0.0%            4.0%            3.8%          |     37.6%           22.2%           19.4%          |
|TERMINAL (d)           |     0/30 (0%)       1/25 (4%)       1/26 (4%)      |     8/25 (32%)      6/27 (22%)      6/31 (19%)     |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         729 (T)       |      427             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.304         P=0.464         P=0.471        |     P=0.041N*       P=0.108N        P=0.060N       |
|INCIDENTAL TUMOR       |     P=0.304         P=0.464         P=0.471        |     P=0.050N        P=0.121N        P=0.077N       |
|LOGISTIC REGRESSION    |     P=0.304         P=0.464         P=0.471        |     P=0.072N        P=0.153N        P=0.111N       |
|COCHRAN-ARMITAGE       |     P=0.329                                        |     P=0.112N                                       |
|FISHER EXACT           |                     P=0.524         P=0.500        |                     P=0.141N        P=0.152N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE   9
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/40 (0%)       1/44 (2%)       1/40 (3%)      |    12/45 (27%)      6/45 (13%)      6/44 (14%)     |
|ADJUSTED (b)           |      0.0%            4.0%            3.8%          |     41.2%           22.2%           19.4%          |
|TERMINAL (d)           |     0/30 (0%)       1/25 (4%)       1/26 (4%)      |     9/25 (36%)      6/27 (22%)      6/31 (19%)     |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         729 (T)       |      427             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.304         P=0.464         P=0.471        |     P=0.022N*       P=0.067N        P=0.034N*      |
|INCIDENTAL TUMOR       |     P=0.304         P=0.464         P=0.471        |     P=0.027N*       P=0.076N        P=0.045N*      |
|LOGISTIC REGRESSION    |     P=0.304         P=0.464         P=0.471        |     P=0.042N*       P=0.102N        P=0.069N       |
|COCHRAN-ARMITAGE       |     P=0.329                                        |     P=0.071N                                       |
|FISHER EXACT           |                     P=0.524         P=0.500        |                     P=0.093N        P=0.102N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/40 (0%)       0/44 (0%)       0/40 (0%)      |     2/45 (4%)       1/45 (2%)       0/44 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      8.0%            3.7%            0.0%          |
|TERMINAL (d)           |     0/30 (0%)       0/25 (0%)       0/26 (0%)      |     2/25 (8%)       1/27 (4%)       0/31 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      729 (T)         729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.110N        P=0.473N        P=0.192N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.110N        P=0.473N        P=0.192N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.110N        P=0.473N        P=0.192N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.145N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.253N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  10
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            3.7%            5.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/35 (0%)       1/27 (4%)       0/29 (0%)      |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         579           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.125         P=0.448         P=0.220        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.228         P=0.448         P=0.464        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.142         P=0.448         P=0.234        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.142                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.247        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      0/50 (0%)       3/50 (6%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     13.8%            0.0%           10.3%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     4/35 (11%)      0/27 (0%)       3/29 (10%)     |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      690             ---             729 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.336N        P=0.058N        P=0.465N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.319N        P=0.023N*       P=0.449N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.308N        P=0.036N*       P=0.434N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.252N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.028N*       P=0.357N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  11
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      8/50 (16%)      7/50 (14%)     |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     16.6%           23.9%           20.9%          |      0.0%            0.0%            2.3%          |
|TERMINAL (d)           |     5/35 (14%)      4/27 (15%)      5/29 (17%)     |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      690             616             422           |      ---             ---             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.326         P=0.265         P=0.386        |     P=0.300           (e)           P=0.540        |
|INCIDENTAL TUMOR       |     P=0.467         P=0.521         P=0.442        |     P=0.175           (e)           P=0.362        |
|LOGISTIC REGRESSION    |     P=0.429         P=0.408         P=0.487        |     P=0.266           (e)           P=0.495        |
|COCHRAN-ARMITAGE       |     P=0.443                                        |     P=0.269                                        |
|FISHER EXACT           |                     P=0.387         P=0.500        |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            2.5%            0.0%          |      0.0%            0.0%            5.0%          |
|TERMINAL (d)           |     0/35 (0%)       0/27 (0%)       0/29 (0%)      |     0/26 (0%)       0/29 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             624             ---           |      ---             ---             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.722         P=0.510           (e)          |     P=0.118           (e)           P=0.282        |
|INCIDENTAL TUMOR       |     P=0.613N        P=0.638           (e)          |     P=0.139           (e)           P=0.316        |
|LOGISTIC REGRESSION    |     P=0.726         P=0.479           (e)          |     P=0.092           (e)           P=0.229        |
|COCHRAN-ARMITAGE       |     P=0.731                                        |     P=0.095                                        |
|FISHER EXACT           |                     P=0.500           (e)          |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  12
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)     10/50 (20%)     10/50 (20%)     |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     24.9%           28.7%           29.0%          |      0.0%            0.0%            2.3%          |
|TERMINAL (d)           |     8/35 (23%)      5/27 (19%)      7/29 (24%)     |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      690             511             422           |      ---             ---             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.313         P=0.336         P=0.358        |     P=0.300           (e)           P=0.540        |
|INCIDENTAL TUMOR       |     P=0.431         P=0.554         P=0.402        |     P=0.175           (e)           P=0.362        |
|LOGISTIC REGRESSION    |     P=0.442         P=0.537         P=0.486        |     P=0.266           (e)           P=0.495        |
|COCHRAN-ARMITAGE       |     P=0.450                                        |     P=0.269                                        |
|FISHER EXACT           |                     P=0.500         P=0.500        |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)     10/50 (20%)      8/50 (16%)     |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     19.4%           28.7%           22.5%          |      0.0%            0.0%            2.3%          |
|TERMINAL (d)           |     6/35 (17%)      5/27 (19%)      5/29 (17%)     |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      690             511             422           |      ---             ---             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.328         P=0.187         P=0.385        |     P=0.300           (e)           P=0.540        |
|INCIDENTAL TUMOR       |     P=0.455         P=0.368         P=0.435        |     P=0.175           (e)           P=0.362        |
|LOGISTIC REGRESSION    |     P=0.445         P=0.328         P=0.496        |     P=0.266           (e)           P=0.495        |
|COCHRAN-ARMITAGE       |     P=0.447                                        |     P=0.269                                        |
|FISHER EXACT           |                     P=0.298         P=0.500        |                       (e)           P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  13
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.9%            5.6%            2.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/35 (3%)       1/27 (4%)       0/29 (0%)      |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         511             466           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.592         P=0.452         P=0.745        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.589         P=0.407         P=0.740        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.610         P=0.494         P=0.758        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.753N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            0.0%            5.9%          |
|TERMINAL (d)           |     0/35 (0%)       0/27 (0%)       0/29 (0%)      |     0/26 (0%)       0/29 (0%)       2/34 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.125           (e)           P=0.299        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.125           (e)           P=0.299        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.125           (e)           P=0.299        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.095                                        |
|FISHER EXACT           |                       (e)             (e)          |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  14
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       5/50 (10%)     |     5/50 (10%)      6/50 (12%)     19/50 (38%)     |
|ADJUSTED (b)           |      2.9%            3.2%           17.2%          |     17.4%           18.1%           47.5%          |
|TERMINAL (d)           |     1/35 (3%)       0/27 (0%)       5/29 (17%)     |     3/26 (12%)      4/29 (14%)     14/34 (41%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         714             729 (T)       |      669             442             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.033 *       P=0.718         P=0.064        |     P=0.004 **      P=0.556         P=0.011 *      |
|INCIDENTAL TUMOR       |     P=0.029 *       P=0.645N        P=0.064        |     P=0.001 **      P=0.494         P=0.003 **     |
|LOGISTIC REGRESSION    |     P=0.032 *       P=0.753         P=0.064        |     P<0.001 **      P=0.515         P=0.003 **     |
|COCHRAN-ARMITAGE       |     P=0.049 *                                      |     P<0.001 **                                     |
|FISHER EXACT           |                     P=0.753N        P=0.102        |                     P=0.500         P<0.001 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       5/50 (10%)     |     5/50 (10%)      6/50 (12%)     18/50 (36%)     |
|ADJUSTED (b)           |      2.9%            3.2%           17.2%          |     17.4%           18.1%           44.9%          |
|TERMINAL (d)           |     1/35 (3%)       0/27 (0%)       5/29 (17%)     |     3/26 (12%)      4/29 (14%)     13/34 (38%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         714             729 (T)       |      669             442             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.033 *       P=0.718         P=0.064        |     P=0.006 **      P=0.556         P=0.016 *      |
|INCIDENTAL TUMOR       |     P=0.029 *       P=0.645N        P=0.064        |     P=0.002 **      P=0.494         P=0.005 **     |
|LOGISTIC REGRESSION    |     P=0.032 *       P=0.753         P=0.064        |     P=0.002 **      P=0.515         P=0.004 **     |
|COCHRAN-ARMITAGE       |     P=0.049 *                                      |     P<0.001 **                                     |
|FISHER EXACT           |                     P=0.753N        P=0.102        |                     P=0.500         P=0.002 **     |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  15
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/45 (0%)       3/50 (6%)       0/49 (0%)      |     3/49 (6%)       4/48 (8%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            9.6%            0.0%          |      8.7%           14.3%            8.2%          |
|TERMINAL (d)           |     0/31 (0%)       2/27 (7%)       0/29 (0%)      |     1/26 (4%)       4/28 (14%)      2/34 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             616             ---           |      582             729 (T)         656           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.621         P=0.112           (e)          |     P=0.454N        P=0.523         P=0.562N       |
|INCIDENTAL TUMOR       |     P=0.582N        P=0.142           (e)          |     P=0.550N        P=0.529         P=0.612        |
|LOGISTIC REGRESSION    |     P=0.625N        P=0.146           (e)          |     P=0.520N        P=0.498         P=0.635N       |
|COCHRAN-ARMITAGE       |     P=0.618N                                       |     P=0.568N                                       |
|FISHER EXACT           |                     P=0.142           (e)          |                     P=0.488         P=0.651N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/45 (0%)       3/50 (6%)       0/49 (0%)      |     4/49 (8%)       4/48 (8%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            9.6%            0.0%          |     12.3%           14.3%            8.2%          |
|TERMINAL (d)           |     0/31 (0%)       2/27 (7%)       0/29 (0%)      |     2/26 (8%)       4/28 (14%)      2/34 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             616             ---           |      582             729 (T)         656           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.621         P=0.112           (e)          |     P=0.301N        P=0.618N        P=0.385N       |
|INCIDENTAL TUMOR       |     P=0.582N        P=0.142           (e)          |     P=0.382N        P=0.613N        P=0.532N       |
|LOGISTIC REGRESSION    |     P=0.625N        P=0.146           (e)          |     P=0.360N        P=0.643         P=0.457N       |
|COCHRAN-ARMITAGE       |     P=0.618N                                       |     P=0.413N                                       |
|FISHER EXACT           |                     P=0.142           (e)          |                     P=0.631         P=0.489N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  16
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |                                                    |      6.7%            0.0%            0.0%          |
|TERMINAL (d)           |                                                    |     0/26 (0%)       0/29 (0%)       0/34 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      693             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.079N        P=0.236N        P=0.194N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.114N        P=0.298N        P=0.262N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.084N        P=0.232N        P=0.210N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.095N                                       |
|FISHER EXACT           |                                                    |                     P=0.247N        P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     3/50 (6%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |                                                    |     10.3%            0.0%            2.9%          |
|TERMINAL (d)           |                                                    |     1/26 (4%)       0/29 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      693             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.132N        P=0.116N        P=0.227N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.166N        P=0.145N        P=0.280N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.142N        P=0.115N        P=0.247N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.176N                                       |
|FISHER EXACT           |                                                    |                     P=0.121N        P=0.309N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  17
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       3/50 (6%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      5.7%            7.3%            0.0%          |      3.8%            0.0%            5.0%          |
|TERMINAL (d)           |     2/35 (6%)       0/27 (0%)       0/29 (0%)      |     1/26 (4%)       0/29 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         514             ---           |      729 (T)         ---             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.243N        P=0.458         P=0.280N       |     P=0.421         P=0.478N        P=0.575        |
|INCIDENTAL TUMOR       |     P=0.168N        P=0.613         P=0.280N       |     P=0.450         P=0.478N        P=0.608        |
|LOGISTIC REGRESSION    |     P=0.202N        P=0.490         P=0.280N       |     P=0.373         P=0.478N        P=0.514        |
|COCHRAN-ARMITAGE       |     P=0.202N                                       |     P=0.360                                        |
|FISHER EXACT           |                     P=0.500         P=0.247N       |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/50 (6%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      8.6%            7.3%            0.0%          |      3.8%            0.0%            5.0%          |
|TERMINAL (d)           |     3/35 (9%)       0/27 (0%)       0/29 (0%)      |     1/26 (4%)       0/29 (0%)       1/34 (3%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         514             ---           |      729 (T)         ---             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.135N        P=0.604         P=0.156N       |     P=0.421         P=0.478N        P=0.575        |
|INCIDENTAL TUMOR       |     P=0.087N        P=0.591N        P=0.156N       |     P=0.450         P=0.478N        P=0.608        |
|LOGISTIC REGRESSION    |     P=0.100N        P=0.662N        P=0.156N       |     P=0.373         P=0.478N        P=0.514        |
|COCHRAN-ARMITAGE       |     P=0.101N                                       |     P=0.360                                        |
|FISHER EXACT           |                     P=0.661N        P=0.121N       |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  18
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      2/50 (4%)       4/50 (8%)      |    16/50 (32%)     11/50 (22%)      9/50 (18%)     |
|ADJUSTED (b)           |     17.8%            7.4%           10.3%          |     42.6%           30.8%           24.6%          |
|TERMINAL (d)           |     4/35 (11%)      2/27 (7%)       0/29 (0%)      |     6/26 (23%)      6/29 (21%)      7/34 (21%)     |
|FIRST INCIDENCE (DAYS) |      527             729 (T)         578           |      452             568             654           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.250N        P=0.127N        P=0.333N       |     P=0.024N*       P=0.171N        P=0.031N*      |
|INCIDENTAL TUMOR       |     P=0.096N        P=0.093N        P=0.098N       |     P=0.063N        P=0.188N        P=0.082N       |
|LOGISTIC REGRESSION    |     P=0.188N        P=0.074N        P=0.262N       |     P=0.037N*       P=0.168N        P=0.050N*      |
|COCHRAN-ARMITAGE       |     P=0.187N                                       |     P=0.064N                                       |
|FISHER EXACT           |                     P=0.080N        P=0.262N       |                     P=0.184N        P=0.083N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      2/50 (4%)       4/50 (8%)      |    16/50 (32%)     11/50 (22%)      9/50 (18%)     |
|ADJUSTED (b)           |     17.8%            7.4%           10.3%          |     42.6%           30.8%           24.6%          |
|TERMINAL (d)           |     4/35 (11%)      2/27 (7%)       0/29 (0%)      |     6/26 (23%)      6/29 (21%)      7/34 (21%)     |
|FIRST INCIDENCE (DAYS) |      527             729 (T)         578           |      452             568             654           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.250N        P=0.127N        P=0.333N       |     P=0.024N*       P=0.171N        P=0.031N*      |
|INCIDENTAL TUMOR       |     P=0.096N        P=0.093N        P=0.098N       |     P=0.063N        P=0.188N        P=0.082N       |
|LOGISTIC REGRESSION    |     P=0.188N        P=0.074N        P=0.262N       |     P=0.037N*       P=0.168N        P=0.050N*      |
|COCHRAN-ARMITAGE       |     P=0.187N                                       |     P=0.064N                                       |
|FISHER EXACT           |                     P=0.080N        P=0.262N       |                     P=0.184N        P=0.083N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  19
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/50 (48%)     26/50 (52%)     28/50 (56%)     |    26/50 (52%)     17/50 (34%)     32/50 (64%)     |
|ADJUSTED (b)           |     62.9%           67.5%           74.8%          |     71.6%           52.2%           72.3%          |
|TERMINAL (d)           |    21/35 (60%)     15/27 (56%)     20/29 (69%)     |    16/26 (62%)     14/29 (48%)     22/34 (65%)     |
|FIRST INCIDENCE (DAYS) |      541             559             573           |      427             442             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.078         P=0.142         P=0.084        |     P=0.530N        P=0.031N*       P=0.507N       |
|INCIDENTAL TUMOR       |     P=0.227         P=0.534         P=0.238        |     P=0.309         P=0.033N*       P=0.308        |
|LOGISTIC REGRESSION    |     P=0.186         P=0.504         P=0.215        |     P=0.283         P=0.034N*       P=0.328        |
|COCHRAN-ARMITAGE       |     P=0.242                                        |     P=0.136                                        |
|FISHER EXACT           |                     P=0.421         P=0.274        |                     P=0.053N        P=0.156        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/50 (48%)     31/50 (62%)     23/50 (46%)     |    24/50 (48%)     15/50 (30%)     18/50 (36%)     |
|ADJUSTED (b)           |     55.7%           68.8%           53.0%          |     60.6%           39.9%           41.4%          |
|TERMINAL (d)           |    16/35 (46%)     14/27 (52%)     10/29 (34%)     |    11/26 (42%)      8/29 (28%)      9/34 (26%)     |
|FIRST INCIDENCE (DAYS) |      527             511             422           |      452             551             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.385         P=0.067         P=0.441        |     P=0.045N*       P=0.056N        P=0.051N       |
|INCIDENTAL TUMOR       |     P=0.185N        P=0.363         P=0.237N       |     P=0.132N        P=0.042N*       P=0.151N       |
|LOGISTIC REGRESSION    |     P=0.189N        P=0.137         P=0.497N       |     P=0.097N        P=0.028N*       P=0.121N       |
|COCHRAN-ARMITAGE       |     P=0.460N                                       |     P=0.129N                                       |
|FISHER EXACT           |                     P=0.114         P=0.500N       |                     P=0.050N        P=0.156N       |
|=================================================================================================================================|
 
         DATE: 09/07/94                     EXPERIMENT: 05049 TEST: 02                                                 PAGE  20
                                 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         10.0            20.0          |      VEHICLE         20.0            40.0          |
|                       |      CONTROL         MG/KG           MG/KG         |      CONTROL         MG/KG           MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    37/50 (74%)     41/50 (82%)     37/50 (74%)     |    37/50 (74%)     26/50 (52%)     37/50 (74%)     |
|ADJUSTED (b)           |     84.1%           88.8%           85.6%          |     90.1%           67.3%           80.3%          |
|TERMINAL (d)           |    28/35 (80%)     22/27 (81%)     23/29 (79%)     |    22/26 (85%)     17/29 (59%)     25/34 (74%)     |
|FIRST INCIDENCE (DAYS) |      527             511             422           |      427             442             520           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.199         P=0.066         P=0.229        |     P=0.112N        P=0.020N*       P=0.103N       |
|INCIDENTAL TUMOR       |     P=0.372N        P=0.503         P=0.456N       |     P=0.316N        P=0.007N**      P=0.313N       |
|LOGISTIC REGRESSION    |     P=0.512N        P=0.417         P=0.566N       |     P=0.270N        P=0.007N**      P=0.265N       |
|COCHRAN-ARMITAGE       |     P=0.547                                        |     P=0.542                                        |
|FISHER EXACT           |                     P=0.235         P=0.590N       |                     P=0.019N*       P=0.590N       |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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