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TDMS Study 05049-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             DICHLORVOS


NTP Experiment-Test: 05049-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: GAVAGE                                                                                                     Time: 02:51:01




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            3            5                                                  
    Accident                                           1                                                                            
    Moribund                                          14           21           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           26           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)                                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Large                                    (50)         (49)         (50)                                                
      Cecum, Parasite Metazoan                         2 (4%)                    1 (2%)                                             
      Colon, Mineralization                                         1 (2%)                                                          
      Colon, Parasite Metazoan                         5 (10%)      1 (2%)       8 (16%)                                            
      Colon, Serosa, Cyst                                                        1 (2%)                                             
      Rectum, Parasite Metazoan                        2 (4%)       3 (6%)       3 (6%)                                             
   Intestine Small                                    (50)         (49)         (50)                                                
      Duodenum, Ectopic Tissue                                      1 (2%)                                                          
      Duodenum, Ulcer                                               1 (2%)                                                          
      Jejunum, Developmental Malformation                                        1 (2%)                                             
      Jejunum, Hemorrhage                                                        1 (2%)                                             
      Jejunum, Hyperplasia, Re Cell                                              1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      3 (6%)                    1 (2%)                                             
      Basophilic Focus                                32 (64%)     27 (54%)     24 (48%)                                            
      Clear Cell Focus                                 1 (2%)       6 (12%)      2 (4%)                                             
      Developmental Malformation                                    2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                            8 (16%)      7 (14%)      6 (12%)                                            
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                     11 (22%)     10 (20%)     13 (26%)                                            
      Mixed Cell Focus                                 1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                          27 (54%)     29 (58%)     17 (34%)                                            
      Capsule, Fibrosis                                                          1 (2%)                                             
      Hepatocyte, Atrophy, Multifocal                  5 (10%)     12 (24%)     11 (22%)                                            
      Hepatocyte, Cytoplasmic Alteration               1 (2%)       1 (2%)                                                          
      Hepatocyte, Hyperplasia, Nodular                 2 (4%)       5 (10%)      3 (6%)                                             
      Hepatocyte, Necrosis, Multifocal                 2 (4%)       3 (6%)       2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            6 (12%)      7 (14%)      5 (10%)                                            
      Hepatocyte, Centrilobular, Necrosis                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Hyperplasia                        1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       4 (8%)       1 (2%)       2 (4%)                                             
      Portal, Fibrosis                                13 (26%)     13 (26%)      3 (6%)                                             
      Vein, Thrombosis                                              1 (2%)                                                          
   Mesentery                                          (10)         (12)         (7)                                                 
      Ectopic Tissue                                                             1 (14%)                                            
      Inflammation, Granulomatous                                   2 (17%)                                                         
      Inflammation, Suppurative                                     1 (8%)                                                          
      Fat, Fibrosis                                                              1 (14%)                                            
      Fat, Hemorrhage                                               1 (8%)                                                          
      Fat, Mineralization                              4 (40%)      1 (8%)       3 (43%)                                            
      Fat, Necrosis, Focal                             9 (90%)     12 (100%)     6 (86%)                                            
   Pancreas                                           (50)         (47)         (50)                                                
      Atrophy                                          5 (10%)      6 (13%)     15 (30%)                                            
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       3 (6%)                                                          
   Pharynx                                            (1)                       (2)                                                 
      Palate, Inflammation, Suppurative                1 (100%)                  1 (50%)                                            
      Palate, Necrosis                                 1 (100%)                  1 (50%)                                            
   Salivary Glands                                    (49)         (50)         (49)                                                
      Ectopic Tissue                                   2 (4%)                    1 (2%)                                             
      Parotid Gland, Hyperplasia, Focal                             1 (2%)                                                          
      Parotid Gland, Vacuolization Cytoplasmic                      1 (2%)                                                          
   Stomach                                            (50)         (49)         (50)                                                
      Forestomach, Diverticulum                        1 (2%)                                                                       
      Forestomach, Edema                               1 (2%)       4 (8%)                                                          
      Forestomach, Foreign Body                                     1 (2%)                                                          
      Forestomach, Granuloma                                        1 (2%)                                                          
      Forestomach, Inflammation, Chronic Active        1 (2%)                                                                       
      Forestomach, Inflammation, Suppurative                        1 (2%)       1 (2%)                                             
      Forestomach, Ulcer                               5 (10%)      6 (12%)      3 (6%)                                             
      Forestomach, Mucosa, Dysplasia                   1 (2%)                    2 (4%)                                             
      Forestomach, Mucosa, Hyperplasia                 5 (10%)      6 (12%)      6 (12%)                                            
      Glandular, Dysplasia                             1 (2%)       1 (2%)                                                          
      Glandular, Edema                                 1 (2%)                                                                       
      Glandular, Erosion                               3 (6%)       4 (8%)       2 (4%)                                             
      Glandular, Inflammation, Suppurative                          1 (2%)                                                          
      Glandular, Mineralization                        5 (10%)     11 (22%)      3 (6%)                                             
      Glandular, Ulcer                                 1 (2%)       3 (6%)                                                          
   Tongue                                             (3)          (1)          (1)                                                 
      Inflammation, Suppurative                        1 (33%)                                                                      
      Epithelium, Hyperplasia                          2 (67%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Thrombosis                                                    1 (2%)                                                          
      Myocardium, Fibrosis                            19 (38%)     18 (36%)      9 (18%)                                            
      Myocardium, Hemorrhage                                        1 (2%)                                                          
      Myocardium, Inflammation, Chronic                8 (16%)      9 (18%)      3 (6%)                                             
      Myocardium, Mineralization                       1 (2%)                                                                       
      Myocardium, Pigmentation                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Infiltration Cellular, Eosinophil                1 (2%)                                                                       
      Infiltration Cellular, Mononuclear Cell                                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       1 (2%)                                                          
      Cortex, Congestion                               1 (2%)                    1 (2%)                                             
      Cortex, Cyst                                     2 (4%)                                                                       
      Cortex, Cytoplasmic Alteration, Diffuse                                    1 (2%)                                             
      Cortex, Hematocyst                                                         1 (2%)                                             
      Cortex, Hyperplasia                              5 (10%)      1 (2%)       7 (14%)                                            
      Cortex, Necrosis                                 1 (2%)                    1 (2%)                                             
      Cortex, Pigmentation                             1 (2%)                                                                       
      Cortex, Vacuolization Cytoplasmic                9 (18%)     17 (34%)     12 (24%)                                            
      Extra Adrenal Tissue, Developmental                                                                                           
          Malformation                                              2 (4%)       1 (2%)                                             
      Medulla, Hyperplasia, Focal                      3 (6%)       2 (4%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (49)         (47)         (45)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Angiectasis                       2 (4%)       4 (8%)       6 (12%)                                            
      Pars Distalis, Cyst                             17 (34%)     19 (39%)     16 (32%)                                            
      Pars Distalis, Hyperplasia                       4 (8%)       5 (10%)      6 (12%)                                            
      Pars Distalis, Pigmentation                                   1 (2%)                                                          
      Pars Intermedia, Cyst                            1 (2%)                                                                       
      Pars Intermedia, Infiltration Cellular                        1 (2%)                                                          
      Pars Nervosa, Hemorrhage                                      1 (2%)                                                          
      Pars Nervosa, Infiltration Cellular                           1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Ultimobranchial Cyst                             2 (4%)                                                                       
      C-Cell, Hyperplasia                             15 (30%)      9 (18%)     10 (20%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (43)         (41)                                                
      Dysplasia                                                                  1 (2%)                                             
      Ectasia                                          4 (9%)       5 (12%)      3 (7%)                                             
      Hyperplasia                                      3 (7%)       3 (7%)       5 (12%)                                            
      Inflammation, Chronic                                         2 (5%)       1 (2%)                                             
      Inflammation, Suppurative                        8 (18%)      6 (14%)      7 (17%)                                            
      Metaplasia, Squamous                             1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)                                                
      Cyst                                             6 (12%)      4 (8%)       6 (12%)                                            
   Uterus                                             (50)         (50)         (50)                                                
      Abscess                                          2 (4%)       4 (8%)       6 (12%)                                            
      Atrophy                                                       1 (2%)                                                          
      Cyst                                                          5 (10%)      1 (2%)                                             
      Hydrometra                                       3 (6%)       1 (2%)       3 (6%)                                             
      Hyperplasia, Cystic                                           6 (12%)      2 (4%)                                             
      Hyperplasia, Glandular                                                     1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                                             
      Prolapse                                                                   1 (2%)                                             
      Endometrium, Dysplasia                                                     1 (2%)                                             
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)       1 (2%)                                             
   Vagina                                             (4)          (8)          (7)                                                 
      Abscess                                                                    1 (14%)                                            
      Cyst                                                                       1 (14%)                                            
      Inflammation, Suppurative                        1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      3 (6%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Reticulum Cell                      8 (16%)      5 (10%)      5 (10%)                                            
      Myelofibrosis                                    1 (2%)       2 (4%)       5 (10%)                                            
   Lymph Node                                         (50)         (50)         (50)                                                
      Axillary, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Axillary, Inflammation, Suppurative              1 (2%)                                                                       
      Axillary, Lymphatic, Ectasia                     1 (2%)                                                                       
      Bronchial, Hemorrhage                            2 (4%)                                                                       
      Bronchial, Infiltration Cellular, Mast Cell      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inguinal, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Lymphatic, Mandibular, Ectasia                   1 (2%)                    2 (4%)                                             
      Mandibular, Hyperplasia, Histiocytic                                       1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Mandibular, Hyperplasia, Plasma Cell             4 (8%)       5 (10%)      7 (14%)                                            
      Mandibular, Infiltration Cellular, Mast Cell                               1 (2%)                                             
      Mediastinal, Erythrophagocytosis                 3 (6%)                    1 (2%)                                             
      Mediastinal, Hemorrhage                          5 (10%)      5 (10%)      6 (12%)                                            
      Mediastinal, Hyperplasia, Histiocytic                                      1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Infiltration Cellular, Mast Cell    1 (2%)                                                                       
      Mediastinal, Pigmentation                       10 (20%)      8 (16%)     10 (20%)                                            
      Mesenteric, Atrophy                              3 (6%)       4 (8%)       5 (10%)                                            
      Mesenteric, Erythrophagocytosis                  1 (2%)                                                                       
      Mesenteric, Hemorrhage                           2 (4%)       2 (4%)       2 (4%)                                             
      Mesenteric, Hyperplasia, Histiocytic             1 (2%)                                                                       
      Mesenteric, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Mesenteric, Infiltration Cellular, Mast Cell     2 (4%)                    1 (2%)                                             
      Mesenteric, Pigmentation                         1 (2%)                                                                       
      Mesenteric, Lymphatic, Ectasia                                             2 (4%)                                             
      Pancreatic, Hemorrhage                                                     1 (2%)                                             
      Pancreatic, Hyperplasia, Histiocytic             1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Developmental Malformation                                    1 (2%)                                                          
      Erythrophagocytosis                              1 (2%)                                                                       
      Fibrosis                                         1 (2%)       5 (10%)      1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    3 (6%)                    2 (4%)                                             
      Hematopoietic Cell Proliferation Erythrocytic    7 (14%)      7 (14%)      9 (18%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                      1 (2%)       2 (4%)                                             
      Pigmentation, Hemosiderin                        2 (4%)       5 (10%)      4 (8%)                                             
   Thymus                                             (39)         (39)         (39)                                                
      Atrophy                                                       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)                                                
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Cystic                             41 (82%)     43 (86%)     35 (71%)                                            
      Hyperplasia, Lobular                             2 (4%)       5 (10%)      3 (6%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
   Skin                                               (50)         (48)         (48)                                                
      Acanthosis                                       2 (4%)       1 (2%)       2 (4%)                                             
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Exudate                                                       1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Developmental Malformation                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperostosis                                                  1 (2%)       2 (4%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Skeletal Muscle                                    (1)          (1)                                                              
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      2 (4%)       5 (10%)      4 (8%)                                             
      Degeneration, Multiple                           7 (14%)      7 (14%)      5 (10%)                                            
      Hydrocephalus                                    1 (2%)       1 (2%)                                                          
      Cerebrum, Degeneration                           2 (4%)       2 (4%)       4 (8%)                                             
      Thalamus, Degeneration                                                     2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                     3 (6%)       1 (2%)       3 (6%)                                             
      Edema, Diffuse                                   1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       3 (6%)                                                                       
      Infiltration Cellular, Histiocyte               35 (70%)     39 (78%)     46 (92%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
   Nose                                               (50)         (49)         (47)                                                
      Lumen, Foreign Body                                           1 (2%)       2 (4%)                                             
      Lumen, Fungus                                    2 (4%)       1 (2%)       3 (6%)                                             
      Lumen, Inflammation, Suppurative                 3 (6%)       4 (8%)       4 (9%)                                             
      Mucosa, Metaplasia, Squamous                     2 (4%)       1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     3 (6%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasopharyngeal Duct, Inflammation,                                                                                            
          Suppurative                                                            1 (2%)                                             
      Submucosa, Inflammation, Chronic                 1 (2%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (23)         (3)                                                 
      Angiectasis                                                   2 (9%)                                                          
      Cataract                                         2 (100%)    23 (100%)     1 (33%)                                            
      Hemorrhage                                                    2 (9%)                                                          
      Retinal Detachment                                                         1 (33%)                                            
      Cornea, Inflammation, Chronic                                 1 (4%)                                                          
      Cornea, Mineralization                                        1 (4%)                                                          
      Retina, Atrophy                                  1 (50%)     23 (100%)     1 (33%)                                            
   Harderian Gland                                                              (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic                            4 (8%)       2 (4%)       3 (6%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Nephropathy                                     34 (68%)     38 (76%)     35 (70%)                                            
      Pelvis, Mineralization                          13 (26%)     19 (38%)     18 (36%)                                            
      Pelvis, Epithelium, Hyperplasia                               1 (2%)       1 (2%)                                             
      Renal Tubule, Mineralization                     4 (8%)      12 (24%)      3 (6%)                                             
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                       8 (16%)      6 (12%)      5 (10%)                                            
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Edema                                            1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           17           18                                                  
    Dead                                               4            3            4                                                  
    Accident                                           1            5            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           25           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
      Cecum, Erosion                                                1 (2%)                                                          
      Cecum, Fibrosis                                                            1 (2%)                                             
      Cecum, Mineralization                                                      1 (2%)                                             
      Cecum, Parasite Metazoan                         4 (8%)                    1 (2%)                                             
      Colon, Edema                                                               1 (2%)                                             
      Colon, Inflammation, Chronic Active                                        1 (2%)                                             
      Colon, Mineralization                            1 (2%)                                                                       
      Colon, Parasite Metazoan                         9 (18%)      6 (12%)                                                         
      Rectum, Parasite Metazoan                        3 (6%)       4 (8%)       4 (8%)                                             
   Intestine Small                                    (50)         (50)         (50)                                                
      Duodenum, Erosion                                                          1 (2%)                                             
      Duodenum, Inflammation, Chronic                                            1 (2%)                                             
      Duodenum, Inflammation, Suppurative                                        1 (2%)                                             
      Duodenum, Mucosa, Hyperplasia                                 1 (2%)                                                          
      Ileum, Mineralization                                         1 (2%)                                                          
      Ileum, Ulcer                                                  1 (2%)                                                          
      Jejunum, Inflammation, Chronic                   2 (4%)                                                                       
      Muscularis, Jejunum, Hyperplasia                                           1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      4 (8%)       3 (6%)       2 (4%)                                             
      Basophilic Focus                                16 (32%)     12 (24%)     10 (20%)                                            
      Clear Cell Focus                                 4 (8%)       7 (14%)      6 (12%)                                            
      Cyst Multilocular                                             6 (12%)      5 (10%)                                            
      Eosinophilic Focus                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       2 (4%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Inflammation, Chronic                            8 (16%)      6 (12%)      4 (8%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)       2 (4%)                                             
      Mixed Cell Focus                                                           1 (2%)                                             
      Bile Duct, Hyperplasia                          47 (94%)     39 (78%)     43 (86%)                                            
      Hepatocyte, Atrophy, Multifocal                  6 (12%)      8 (16%)      9 (18%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hyperplasia, Nodular                 1 (2%)       6 (12%)      3 (6%)                                             
      Hepatocyte, Necrosis, Multifocal                 3 (6%)       1 (2%)       1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)     13 (26%)     19 (38%)                                            
      Hepatocyte, Centrilobular, Necrosis              3 (6%)                    1 (2%)                                             
      Portal, Fibrosis                                24 (48%)     14 (28%)     15 (30%)                                            
   Mesentery                                          (9)          (7)          (8)                                                 
      Ectopic Tissue                                                1 (14%)                                                         
      Inflammation, Chronic Active                     1 (11%)                                                                      
      Mineralization                                                             1 (13%)                                            
      Pigmentation                                     1 (11%)                                                                      
      Fat, Fibrosis                                                 1 (14%)                                                         
      Fat, Inflammation, Granulomatous                              1 (14%)      1 (13%)                                            
      Fat, Inflammation, Suppurative                                2 (29%)                                                         
      Fat, Necrosis                                    1 (11%)                                                                      
      Fat, Necrosis, Focal                             3 (33%)      2 (29%)      6 (75%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Atrophy                                         17 (34%)     14 (29%)     18 (36%)                                            
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      9 (18%)      9 (18%)      9 (18%)                                            
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Pharynx                                            (1)          (2)          (1)                                                 
      Palate, Hyperplasia                              1 (100%)                                                                     
      Palate, Inflammation, Suppurative                1 (100%)                                                                     
      Palate, Ulcer                                                 2 (100%)                                                        
   Salivary Glands                                    (48)         (48)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
   Stomach                                            (50)         (49)         (50)                                                
      Forestomach, Diverticulum                                     1 (2%)                                                          
      Forestomach, Edema                                            1 (2%)       1 (2%)                                             
      Forestomach, Erosion                                                       2 (4%)                                             
      Forestomach, Fibrosis                                                      1 (2%)                                             
      Forestomach, Inflammation, Chronic               1 (2%)       1 (2%)       2 (4%)                                             
      Forestomach, Inflammation, Chronic Active        1 (2%)                    1 (2%)                                             
      Forestomach, Inflammation, Suppurative                        1 (2%)                                                          
      Forestomach, Mineralization                      2 (4%)       2 (4%)       1 (2%)                                             
      Forestomach, Necrosis                                         1 (2%)                                                          
      Forestomach, Perforation                                      2 (4%)       1 (2%)                                             
      Forestomach, Ulcer                               2 (4%)       3 (6%)       2 (4%)                                             
      Forestomach, Mucosa, Dysplasia                                1 (2%)                                                          
      Forestomach, Mucosa, Hyperplasia                 9 (18%)      8 (16%)      6 (12%)                                            
      Glandular, Cyst                                  1 (2%)                                                                       
      Glandular, Erosion                               4 (8%)       3 (6%)       1 (2%)                                             
      Glandular, Hemorrhage                                         1 (2%)                                                          
      Glandular, Inflammation, Chronic Active                                    1 (2%)                                             
      Glandular, Mineralization                       10 (20%)      9 (18%)      4 (8%)                                             
      Glandular, Necrosis                                           1 (2%)                                                          
      Glandular, Ulcer                                              1 (2%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tongue                                                          (1)          (2)                                                 
      Epithelium, Hyperplasia                                       1 (100%)     1 (50%)                                            
   Tooth                                              (2)          (1)                                                              
      Inflammation, Chronic                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (4)          (4)          (3)                                                 
      Hypertrophy                                      2 (50%)      2 (50%)                                                         
      Inflammation, Chronic Active                     2 (50%)      3 (75%)      3 (100%)                                           
      Mineralization                                   1 (25%)      1 (25%)      1 (33%)                                            
      Thrombosis                                                    1 (25%)                                                         
   Heart                                              (50)         (50)         (49)                                                
      Thrombosis                                       2 (4%)                    3 (6%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
      Myocardium, Fibrosis                            36 (72%)     38 (76%)     36 (73%)                                            
      Myocardium, Inflammation, Chronic                9 (18%)      9 (18%)      3 (6%)                                             
      Myocardium, Inflammation, Chronic Active         1 (2%)       2 (4%)                                                          
      Myocardium, Metaplasia, Osseous                  1 (2%)       1 (2%)                                                          
      Myocardium, Mineralization                       2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
      Cortex, Cyst                                     2 (4%)       1 (2%)                                                          
      Cortex, Fibrosis                                 1 (2%)                                                                       
      Cortex, Hematocyst                               3 (6%)       1 (2%)                                                          
      Cortex, Hyperplasia                              3 (6%)       3 (6%)       1 (2%)                                             
      Cortex, Inflammation, Suppurative                1 (2%)                                                                       
      Cortex, Necrosis                                              1 (2%)                                                          
      Cortex, Vacuolization Cytoplasmic                3 (6%)       8 (16%)     13 (26%)                                            
      Extra Adrenal Tissue, Developmental                                                                                           
          Malformation                                 3 (6%)       2 (4%)       2 (4%)                                             
      Medulla, Hyperplasia                             3 (6%)       5 (10%)      4 (8%)                                             
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (48)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Pars Distalis, Angiectasis                       1 (2%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Cyst                              4 (8%)       5 (10%)      2 (4%)                                             
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                       5 (10%)      4 (8%)       3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Necrosis                                                    1 (2%)                                             
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                            2 (4%)                    3 (6%)                                             
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Ultimobranchial Cyst                                          2 (4%)       2 (4%)                                             
      C-Cell, Hyperplasia                              7 (14%)      4 (8%)      11 (22%)                                            
      Follicle, Dilatation                             1 (2%)                    4 (8%)                                             
      Follicle, Pigmentation                           2 (4%)       2 (4%)                                                          
      Follicular Cell, Hyperplasia                                  2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)                                                 
      Ectasia                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)                                                
      Edema                                            1 (2%)                                                                       
   Preputial Gland                                    (48)         (46)         (45)                                                
      Cyst                                             1 (2%)                                                                       
      Ectasia                                                       6 (13%)      1 (2%)                                             
      Hyperplasia                                      9 (19%)      3 (7%)       5 (11%)                                            
      Inflammation, Chronic                           16 (33%)     16 (35%)     12 (27%)                                            
      Inflammation, Suppurative                       16 (33%)     13 (28%)     10 (22%)                                            
      Metaplasia, Squamous                                          1 (2%)                                                          
   Prostate                                           (50)         (50)         (49)                                                
      Corpora Amylacea                                 6 (12%)      4 (8%)       3 (6%)                                             
      Edema                                                                      1 (2%)                                             
      Fibrosis                                         2 (4%)                                                                       
      Foreign Body                                                  1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                       17 (34%)     18 (36%)     17 (35%)                                            
      Epithelium, Hyperplasia                          1 (2%)       2 (4%)       2 (4%)                                             
   Seminal Vesicle                                    (3)          (4)          (2)                                                 
      Fibrosis                                                      1 (25%)                                                         
   Testes                                             (50)         (50)         (50)                                                
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Interstitial Cell, Hyperplasia                   2 (4%)                    1 (2%)                                             
      Seminiferous Tubule, Atrophy                     6 (12%)      6 (12%)      3 (6%)                                             
      Seminiferous Tubule, Mineralization             17 (34%)     20 (40%)     14 (28%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Reticulum Cell                      1 (2%)       1 (2%)       1 (2%)                                             
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)                                                
      Axillary, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Bronchial, Pigmentation                                                    1 (2%)                                             
      Inguinal, Hemorrhage                             1 (2%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Inguinal, Lymphatic, Ectasia                     1 (2%)                    1 (2%)                                             
      Lumbar, Lymphatic, Ectasia                                                 1 (2%)                                             
      Lymphatic, Mandibular, Ectasia                   4 (8%)       4 (8%)       7 (14%)                                            
      Mandibular, Hyperplasia, Lymphoid                             2 (4%)                                                          
      Mandibular, Hyperplasia, Plasma Cell             8 (16%)      7 (14%)      6 (12%)                                            
      Mandibular, Metaplasia, Osseous                  1 (2%)                                                                       
      Mediastinal, Atrophy                             1 (2%)                    1 (2%)                                             
      Mediastinal, Erythrophagocytosis                 2 (4%)       3 (6%)       1 (2%)                                             
      Mediastinal, Hemorrhage                          6 (12%)      4 (8%)       3 (6%)                                             
      Mediastinal, Hyperplasia, Histiocytic                         1 (2%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)       1 (2%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)                                                          
      Mediastinal, Pigmentation                        3 (6%)       3 (6%)       3 (6%)                                             
      Mediastinal, Lymphatic, Ectasia                  1 (2%)       2 (4%)       1 (2%)                                             
      Mesenteric, Atrophy                              3 (6%)       2 (4%)       5 (10%)                                            
      Mesenteric, Hematopoietic Cell Proliferation     1 (2%)                                                                       
      Mesenteric, Hemorrhage                                        1 (2%)       1 (2%)                                             
      Mesenteric, Hyperplasia, Histiocytic             1 (2%)                                                                       
      Mesenteric, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Mesenteric, Hyperplasia, Plasma Cell             1 (2%)                                                                       
      Mesenteric, Necrosis                             1 (2%)                                                                       
      Mesenteric, Lymphatic, Ectasia                   2 (4%)                    1 (2%)                                             
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Pancreatic, Pigmentation                         1 (2%)                                                                       
      Pancreatic, Lymphatic, Ectasia                   1 (2%)                                                                       
      Renal, Pigmentation                                                        1 (2%)                                             
   Spleen                                             (49)         (50)         (50)                                                
      Atrophy                                          4 (8%)       3 (6%)                                                          
      Congestion                                       1 (2%)                                                                       
      Degeneration, Fatty                              1 (2%)                                                                       
      Fibrosis                                         4 (8%)       6 (12%)      1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)       2 (4%)       3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation Erythrocytic    9 (18%)      8 (16%)      8 (16%)                                            
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Necrosis                                                      2 (4%)                                                          
      Pigmentation, Hemosiderin                        2 (4%)       1 (2%)       1 (2%)                                             
      Lymphatic, Ectasia                               1 (2%)       1 (2%)                                                          
   Thymus                                             (34)         (29)         (34)                                                
      Cyst                                             5 (15%)      1 (3%)       1 (3%)                                             
      Ectopic Parathyroid Gland                        1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (44)         (46)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia, Cystic                             16 (35%)     13 (30%)     12 (26%)                                            
      Hyperplasia, Lobular                             1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
   Skin                                               (49)         (49)         (49)                                                
      Acanthosis                                                    4 (8%)       3 (6%)                                             
      Cyst Epithelial Inclusion                        2 (4%)       1 (2%)       1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Exudate                                                                    3 (6%)                                             
      Foreign Body                                     1 (2%)                                                                       
      Hyperkeratosis                                                3 (6%)       1 (2%)                                             
      Inflammation, Chronic                                         3 (6%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Suppurative                        2 (4%)       2 (4%)       2 (4%)                                             
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                           2 (4%)                                                                       
      Hyperostosis                                     2 (4%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Skeletal Muscle                                    (1)          (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (48)                                                
      Compression                                      2 (4%)       1 (2%)                                                          
      Degeneration, Multiple                           3 (6%)       8 (16%)      4 (8%)                                             
      Necrosis                                                                   1 (2%)                                             
      Cerebellum, Mineralization                                                 1 (2%)                                             
      Cerebrum, Degeneration                           1 (2%)       1 (2%)       1 (2%)                                             
      Cerebrum, Hemorrhage                                                       1 (2%)                                             
      Cerebrum, Necrosis                                                         1 (2%)                                             
      Thalamus, Degeneration                                                     1 (2%)                                             
      Thalamus, Hemorrhage                             1 (2%)                                                                       
   Peripheral Nerve                                   (50)         (48)         (48)                                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte,                                                                                            
          Polymorphonuclear                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Adenomatosis                                     5 (10%)      4 (8%)       3 (6%)                                             
      Edema, Diffuse                                   1 (2%)       2 (4%)       1 (2%)                                             
      Foreign Body                                                  6 (12%)      2 (4%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Infiltration Cellular, Histiocyte               28 (56%)     27 (54%)     29 (59%)                                            
      Inflammation, Chronic                            1 (2%)       2 (4%)                                                          
      Inflammation, Granulomatous                      4 (8%)       2 (4%)       3 (6%)                                             
      Inflammation, Suppurative                        2 (4%)                                                                       
      Metaplasia, Osseous                                           1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Artery, Mineralization                           2 (4%)                                                                       
      Artery, Media, Hypertrophy                                    2 (4%)                                                          
      Parenchyma, Mineralization                       1 (2%)                                                                       
   Nose                                               (49)         (49)         (47)                                                
      Lumen, Foreign Body                              2 (4%)       1 (2%)                                                          
      Lumen, Fungus                                    4 (8%)       1 (2%)       1 (2%)                                             
      Lumen, Hemorrhage                                             1 (2%)                                                          
      Lumen, Inflammation, Suppurative                 8 (16%)      3 (6%)       7 (15%)                                            
      Mucosa, Hyperplasia                              1 (2%)                    1 (2%)                                             
      Mucosa, Inflammation, Chronic                    1 (2%)                                                                       
      Mucosa, Metaplasia, Squamous                                  1 (2%)                                                          
      Mucosa, Necrosis                                 1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                                   1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       2 (4%)       1 (2%)                                             
      Nasopharyngeal Duct, Foreign Body                             1 (2%)                                                          
      Nasopharyngeal Duct, Inflammation,                                                                                            
          Suppurative                                               1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05049-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:51:01  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Submucosa, Inflammation, Chronic                 1 (2%)       3 (6%)       2 (4%)                                             
   Trachea                                            (49)         (49)         (49)                                                
      Lumen, Exudate                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Middle Ear, Inflammation, Suppurative                                      1 (100%)                                           
   Eye                                                (2)          (2)          (28)                                                
      Angiectasis                                                                1 (4%)                                             
      Cataract                                         1 (50%)      1 (50%)     25 (89%)                                            
      Retinal Detachment                                                         1 (4%)                                             
      Synechia                                                                   1 (4%)                                             
      Retina, Atrophy                                  2 (100%)     2 (100%)    28 (100%)                                           
   Harderian Gland                                    (1)                                                                           
      Hyperplasia                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hydronephrosis                                   3 (6%)                                                                       
      Inflammation, Chronic                           30 (60%)     30 (60%)     27 (54%)                                            
      Inflammation, Suppurative                        6 (12%)      6 (12%)      8 (16%)                                            
      Nephropathy                                     50 (100%)    49 (98%)     49 (98%)                                            
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Mineralization                           1 (2%)       1 (2%)                                                          
      Pelvis, Epithelium, Hyperplasia                               1 (2%)                                                          
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Mineralization                     8 (16%)     12 (24%)      6 (12%)                                            
      Renal Tubule, Pigmentation                       3 (6%)       3 (6%)       2 (4%)                                             
   Ureter                                             (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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