TDMS Study 05049-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DICHLORVOS
NTP Experiment-Test: 05049-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: GAVAGE Time: 02:51:01
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 4 3 5
Accident 1
Moribund 14 21 19
Survivors
Terminal Sacrifice 31 26 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50)
Ulcer 1 (2%)
Intestine Large (50) (49) (50)
Cecum, Parasite Metazoan 2 (4%) 1 (2%)
Colon, Mineralization 1 (2%)
Colon, Parasite Metazoan 5 (10%) 1 (2%) 8 (16%)
Colon, Serosa, Cyst 1 (2%)
Rectum, Parasite Metazoan 2 (4%) 3 (6%) 3 (6%)
Intestine Small (50) (49) (50)
Duodenum, Ectopic Tissue 1 (2%)
Duodenum, Ulcer 1 (2%)
Jejunum, Developmental Malformation 1 (2%)
Jejunum, Hemorrhage 1 (2%)
Jejunum, Hyperplasia, Re Cell 1 (2%)
Liver (50) (50) (50)
Angiectasis 3 (6%) 1 (2%)
Basophilic Focus 32 (64%) 27 (54%) 24 (48%)
Clear Cell Focus 1 (2%) 6 (12%) 2 (4%)
Developmental Malformation 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 8 (16%) 7 (14%) 6 (12%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 11 (22%) 10 (20%) 13 (26%)
Mixed Cell Focus 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 27 (54%) 29 (58%) 17 (34%)
Capsule, Fibrosis 1 (2%)
Hepatocyte, Atrophy, Multifocal 5 (10%) 12 (24%) 11 (22%)
Hepatocyte, Cytoplasmic Alteration 1 (2%) 1 (2%)
Hepatocyte, Hyperplasia, Nodular 2 (4%) 5 (10%) 3 (6%)
Hepatocyte, Necrosis, Multifocal 2 (4%) 3 (6%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 7 (14%) 5 (10%)
Hepatocyte, Centrilobular, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 4 (8%) 1 (2%) 2 (4%)
Portal, Fibrosis 13 (26%) 13 (26%) 3 (6%)
Vein, Thrombosis 1 (2%)
Mesentery (10) (12) (7)
Ectopic Tissue 1 (14%)
Inflammation, Granulomatous 2 (17%)
Inflammation, Suppurative 1 (8%)
Fat, Fibrosis 1 (14%)
Fat, Hemorrhage 1 (8%)
Fat, Mineralization 4 (40%) 1 (8%) 3 (43%)
Fat, Necrosis, Focal 9 (90%) 12 (100%) 6 (86%)
Pancreas (50) (47) (50)
Atrophy 5 (10%) 6 (13%) 15 (30%)
Cyst 1 (2%)
Cytoplasmic Alteration 1 (2%)
Hyperplasia 2 (4%) 3 (6%)
Pharynx (1) (2)
Palate, Inflammation, Suppurative 1 (100%) 1 (50%)
Palate, Necrosis 1 (100%) 1 (50%)
Salivary Glands (49) (50) (49)
Ectopic Tissue 2 (4%) 1 (2%)
Parotid Gland, Hyperplasia, Focal 1 (2%)
Parotid Gland, Vacuolization Cytoplasmic 1 (2%)
Stomach (50) (49) (50)
Forestomach, Diverticulum 1 (2%)
Forestomach, Edema 1 (2%) 4 (8%)
Forestomach, Foreign Body 1 (2%)
Forestomach, Granuloma 1 (2%)
Forestomach, Inflammation, Chronic Active 1 (2%)
Forestomach, Inflammation, Suppurative 1 (2%) 1 (2%)
Forestomach, Ulcer 5 (10%) 6 (12%) 3 (6%)
Forestomach, Mucosa, Dysplasia 1 (2%) 2 (4%)
Forestomach, Mucosa, Hyperplasia 5 (10%) 6 (12%) 6 (12%)
Glandular, Dysplasia 1 (2%) 1 (2%)
Glandular, Edema 1 (2%)
Glandular, Erosion 3 (6%) 4 (8%) 2 (4%)
Glandular, Inflammation, Suppurative 1 (2%)
Glandular, Mineralization 5 (10%) 11 (22%) 3 (6%)
Glandular, Ulcer 1 (2%) 3 (6%)
Tongue (3) (1) (1)
Inflammation, Suppurative 1 (33%)
Epithelium, Hyperplasia 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Thrombosis 1 (2%)
Myocardium, Fibrosis 19 (38%) 18 (36%) 9 (18%)
Myocardium, Hemorrhage 1 (2%)
Myocardium, Inflammation, Chronic 8 (16%) 9 (18%) 3 (6%)
Myocardium, Mineralization 1 (2%)
Myocardium, Pigmentation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Eosinophil 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Cortex, Congestion 1 (2%) 1 (2%)
Cortex, Cyst 2 (4%)
Cortex, Cytoplasmic Alteration, Diffuse 1 (2%)
Cortex, Hematocyst 1 (2%)
Cortex, Hyperplasia 5 (10%) 1 (2%) 7 (14%)
Cortex, Necrosis 1 (2%) 1 (2%)
Cortex, Pigmentation 1 (2%)
Cortex, Vacuolization Cytoplasmic 9 (18%) 17 (34%) 12 (24%)
Extra Adrenal Tissue, Developmental
Malformation 2 (4%) 1 (2%)
Medulla, Hyperplasia, Focal 3 (6%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (48) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (47) (45)
Hyperplasia 1 (2%)
Pigmentation 1 (2%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Angiectasis 2 (4%) 4 (8%) 6 (12%)
Pars Distalis, Cyst 17 (34%) 19 (39%) 16 (32%)
Pars Distalis, Hyperplasia 4 (8%) 5 (10%) 6 (12%)
Pars Distalis, Pigmentation 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Infiltration Cellular 1 (2%)
Pars Nervosa, Hemorrhage 1 (2%)
Pars Nervosa, Infiltration Cellular 1 (2%)
Thyroid Gland (50) (49) (50)
Inflammation, Chronic 1 (2%)
Ultimobranchial Cyst 2 (4%)
C-Cell, Hyperplasia 15 (30%) 9 (18%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (43) (41)
Dysplasia 1 (2%)
Ectasia 4 (9%) 5 (12%) 3 (7%)
Hyperplasia 3 (7%) 3 (7%) 5 (12%)
Inflammation, Chronic 2 (5%) 1 (2%)
Inflammation, Suppurative 8 (18%) 6 (14%) 7 (17%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (50) (50)
Cyst 6 (12%) 4 (8%) 6 (12%)
Uterus (50) (50) (50)
Abscess 2 (4%) 4 (8%) 6 (12%)
Atrophy 1 (2%)
Cyst 5 (10%) 1 (2%)
Hydrometra 3 (6%) 1 (2%) 3 (6%)
Hyperplasia, Cystic 6 (12%) 2 (4%)
Hyperplasia, Glandular 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Prolapse 1 (2%)
Endometrium, Dysplasia 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Vagina (4) (8) (7)
Abscess 1 (14%)
Cyst 1 (14%)
Inflammation, Suppurative 1 (25%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Hemorrhage 1 (2%)
Hyperplasia 3 (6%) 1 (2%) 2 (4%)
Hyperplasia, Reticulum Cell 8 (16%) 5 (10%) 5 (10%)
Myelofibrosis 1 (2%) 2 (4%) 5 (10%)
Lymph Node (50) (50) (50)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Axillary, Inflammation, Suppurative 1 (2%)
Axillary, Lymphatic, Ectasia 1 (2%)
Bronchial, Hemorrhage 2 (4%)
Bronchial, Infiltration Cellular, Mast Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Lymphatic, Mandibular, Ectasia 1 (2%) 2 (4%)
Mandibular, Hyperplasia, Histiocytic 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 4 (8%) 5 (10%) 7 (14%)
Mandibular, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Erythrophagocytosis 3 (6%) 1 (2%)
Mediastinal, Hemorrhage 5 (10%) 5 (10%) 6 (12%)
Mediastinal, Hyperplasia, Histiocytic 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Pigmentation 10 (20%) 8 (16%) 10 (20%)
Mesenteric, Atrophy 3 (6%) 4 (8%) 5 (10%)
Mesenteric, Erythrophagocytosis 1 (2%)
Mesenteric, Hemorrhage 2 (4%) 2 (4%) 2 (4%)
Mesenteric, Hyperplasia, Histiocytic 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Mesenteric, Infiltration Cellular, Mast Cell 2 (4%) 1 (2%)
Mesenteric, Pigmentation 1 (2%)
Mesenteric, Lymphatic, Ectasia 2 (4%)
Pancreatic, Hemorrhage 1 (2%)
Pancreatic, Hyperplasia, Histiocytic 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (50) (50)
Congestion 1 (2%)
Developmental Malformation 1 (2%)
Erythrophagocytosis 1 (2%)
Fibrosis 1 (2%) 5 (10%) 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 3 (6%) 2 (4%)
Hematopoietic Cell Proliferation Erythrocytic 7 (14%) 7 (14%) 9 (18%)
Hemorrhage 1 (2%)
Necrosis 1 (2%) 2 (4%)
Pigmentation, Hemosiderin 2 (4%) 5 (10%) 4 (8%)
Thymus (39) (39) (39)
Atrophy 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49)
Fibrosis 1 (2%)
Hyperplasia, Cystic 41 (82%) 43 (86%) 35 (71%)
Hyperplasia, Lobular 2 (4%) 5 (10%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Skin (50) (48) (48)
Acanthosis 2 (4%) 1 (2%) 2 (4%)
Cyst Epithelial Inclusion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Exudate 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Developmental Malformation 1 (2%)
Hemorrhage 1 (2%)
Hyperostosis 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
Skeletal Muscle (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 2 (4%) 5 (10%) 4 (8%)
Degeneration, Multiple 7 (14%) 7 (14%) 5 (10%)
Hydrocephalus 1 (2%) 1 (2%)
Cerebrum, Degeneration 2 (4%) 2 (4%) 4 (8%)
Thalamus, Degeneration 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenomatosis 3 (6%) 1 (2%) 3 (6%)
Edema, Diffuse 1 (2%)
Fibrosis 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 3 (6%)
Infiltration Cellular, Histiocyte 35 (70%) 39 (78%) 46 (92%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Mineralization 1 (2%)
Nose (50) (49) (47)
Lumen, Foreign Body 1 (2%) 2 (4%)
Lumen, Fungus 2 (4%) 1 (2%) 3 (6%)
Lumen, Inflammation, Suppurative 3 (6%) 4 (8%) 4 (9%)
Mucosa, Metaplasia, Squamous 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasopharyngeal Duct, Inflammation,
Suppurative 1 (2%)
Submucosa, Inflammation, Chronic 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (23) (3)
Angiectasis 2 (9%)
Cataract 2 (100%) 23 (100%) 1 (33%)
Hemorrhage 2 (9%)
Retinal Detachment 1 (33%)
Cornea, Inflammation, Chronic 1 (4%)
Cornea, Mineralization 1 (4%)
Retina, Atrophy 1 (50%) 23 (100%) 1 (33%)
Harderian Gland (1)
Hemorrhage 1 (100%)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 4 (8%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Nephropathy 34 (68%) 38 (76%) 35 (70%)
Pelvis, Mineralization 13 (26%) 19 (38%) 18 (36%)
Pelvis, Epithelium, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Mineralization 4 (8%) 12 (24%) 3 (6%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 8 (16%) 6 (12%) 5 (10%)
Urinary Bladder (50) (49) (50)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 14 17 18
Dead 4 3 4
Accident 1 5 4
Survivors
Terminal Sacrifice 31 25 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Cecum, Erosion 1 (2%)
Cecum, Fibrosis 1 (2%)
Cecum, Mineralization 1 (2%)
Cecum, Parasite Metazoan 4 (8%) 1 (2%)
Colon, Edema 1 (2%)
Colon, Inflammation, Chronic Active 1 (2%)
Colon, Mineralization 1 (2%)
Colon, Parasite Metazoan 9 (18%) 6 (12%)
Rectum, Parasite Metazoan 3 (6%) 4 (8%) 4 (8%)
Intestine Small (50) (50) (50)
Duodenum, Erosion 1 (2%)
Duodenum, Inflammation, Chronic 1 (2%)
Duodenum, Inflammation, Suppurative 1 (2%)
Duodenum, Mucosa, Hyperplasia 1 (2%)
Ileum, Mineralization 1 (2%)
Ileum, Ulcer 1 (2%)
Jejunum, Inflammation, Chronic 2 (4%)
Muscularis, Jejunum, Hyperplasia 1 (2%)
Liver (50) (50) (50)
Angiectasis 4 (8%) 3 (6%) 2 (4%)
Basophilic Focus 16 (32%) 12 (24%) 10 (20%)
Clear Cell Focus 4 (8%) 7 (14%) 6 (12%)
Cyst Multilocular 6 (12%) 5 (10%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 2 (4%)
Hemorrhage 2 (4%)
Inflammation, Chronic 8 (16%) 6 (12%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Mixed Cell Focus 1 (2%)
Bile Duct, Hyperplasia 47 (94%) 39 (78%) 43 (86%)
Hepatocyte, Atrophy, Multifocal 6 (12%) 8 (16%) 9 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Hyperplasia, Nodular 1 (2%) 6 (12%) 3 (6%)
Hepatocyte, Necrosis, Multifocal 3 (6%) 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 13 (26%) 19 (38%)
Hepatocyte, Centrilobular, Necrosis 3 (6%) 1 (2%)
Portal, Fibrosis 24 (48%) 14 (28%) 15 (30%)
Mesentery (9) (7) (8)
Ectopic Tissue 1 (14%)
Inflammation, Chronic Active 1 (11%)
Mineralization 1 (13%)
Pigmentation 1 (11%)
Fat, Fibrosis 1 (14%)
Fat, Inflammation, Granulomatous 1 (14%) 1 (13%)
Fat, Inflammation, Suppurative 2 (29%)
Fat, Necrosis 1 (11%)
Fat, Necrosis, Focal 3 (33%) 2 (29%) 6 (75%)
Pancreas (50) (49) (50)
Atrophy 17 (34%) 14 (29%) 18 (36%)
Cyst 1 (2%)
Hyperplasia 9 (18%) 9 (18%) 9 (18%)
Infiltration Cellular, Lymphocyte 1 (2%)
Pharynx (1) (2) (1)
Palate, Hyperplasia 1 (100%)
Palate, Inflammation, Suppurative 1 (100%)
Palate, Ulcer 2 (100%)
Salivary Glands (48) (48) (49)
Atrophy 1 (2%)
Stomach (50) (49) (50)
Forestomach, Diverticulum 1 (2%)
Forestomach, Edema 1 (2%) 1 (2%)
Forestomach, Erosion 2 (4%)
Forestomach, Fibrosis 1 (2%)
Forestomach, Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Forestomach, Inflammation, Chronic Active 1 (2%) 1 (2%)
Forestomach, Inflammation, Suppurative 1 (2%)
Forestomach, Mineralization 2 (4%) 2 (4%) 1 (2%)
Forestomach, Necrosis 1 (2%)
Forestomach, Perforation 2 (4%) 1 (2%)
Forestomach, Ulcer 2 (4%) 3 (6%) 2 (4%)
Forestomach, Mucosa, Dysplasia 1 (2%)
Forestomach, Mucosa, Hyperplasia 9 (18%) 8 (16%) 6 (12%)
Glandular, Cyst 1 (2%)
Glandular, Erosion 4 (8%) 3 (6%) 1 (2%)
Glandular, Hemorrhage 1 (2%)
Glandular, Inflammation, Chronic Active 1 (2%)
Glandular, Mineralization 10 (20%) 9 (18%) 4 (8%)
Glandular, Necrosis 1 (2%)
Glandular, Ulcer 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tongue (1) (2)
Epithelium, Hyperplasia 1 (100%) 1 (50%)
Tooth (2) (1)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4) (4) (3)
Hypertrophy 2 (50%) 2 (50%)
Inflammation, Chronic Active 2 (50%) 3 (75%) 3 (100%)
Mineralization 1 (25%) 1 (25%) 1 (33%)
Thrombosis 1 (25%)
Heart (50) (50) (49)
Thrombosis 2 (4%) 3 (6%)
Artery, Mineralization 1 (2%)
Myocardium, Fibrosis 36 (72%) 38 (76%) 36 (73%)
Myocardium, Inflammation, Chronic 9 (18%) 9 (18%) 3 (6%)
Myocardium, Inflammation, Chronic Active 1 (2%) 2 (4%)
Myocardium, Metaplasia, Osseous 1 (2%) 1 (2%)
Myocardium, Mineralization 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Pigmentation 1 (2%)
Cortex, Cyst 2 (4%) 1 (2%)
Cortex, Fibrosis 1 (2%)
Cortex, Hematocyst 3 (6%) 1 (2%)
Cortex, Hyperplasia 3 (6%) 3 (6%) 1 (2%)
Cortex, Inflammation, Suppurative 1 (2%)
Cortex, Necrosis 1 (2%)
Cortex, Vacuolization Cytoplasmic 3 (6%) 8 (16%) 13 (26%)
Extra Adrenal Tissue, Developmental
Malformation 3 (6%) 2 (4%) 2 (4%)
Medulla, Hyperplasia 3 (6%) 5 (10%) 4 (8%)
Islets, Pancreatic (50) (48) (50)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (48) (49)
Angiectasis 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Cyst 4 (8%) 5 (10%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 4 (8%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Necrosis 1 (2%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 3 (6%)
Thyroid Gland (49) (49) (49)
Ultimobranchial Cyst 2 (4%) 2 (4%)
C-Cell, Hyperplasia 7 (14%) 4 (8%) 11 (22%)
Follicle, Dilatation 1 (2%) 4 (8%)
Follicle, Pigmentation 2 (4%) 2 (4%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Ectasia 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49)
Edema 1 (2%)
Preputial Gland (48) (46) (45)
Cyst 1 (2%)
Ectasia 6 (13%) 1 (2%)
Hyperplasia 9 (19%) 3 (7%) 5 (11%)
Inflammation, Chronic 16 (33%) 16 (35%) 12 (27%)
Inflammation, Suppurative 16 (33%) 13 (28%) 10 (22%)
Metaplasia, Squamous 1 (2%)
Prostate (50) (50) (49)
Corpora Amylacea 6 (12%) 4 (8%) 3 (6%)
Edema 1 (2%)
Fibrosis 2 (4%)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 17 (34%) 18 (36%) 17 (35%)
Epithelium, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Seminal Vesicle (3) (4) (2)
Fibrosis 1 (25%)
Testes (50) (50) (50)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%) 1 (2%)
Seminiferous Tubule, Atrophy 6 (12%) 6 (12%) 3 (6%)
Seminiferous Tubule, Mineralization 17 (34%) 20 (40%) 14 (28%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%) 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (50) (50) (50)
Axillary, Hyperplasia, Plasma Cell 1 (2%)
Bronchial, Pigmentation 1 (2%)
Inguinal, Hemorrhage 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Inguinal, Lymphatic, Ectasia 1 (2%) 1 (2%)
Lumbar, Lymphatic, Ectasia 1 (2%)
Lymphatic, Mandibular, Ectasia 4 (8%) 4 (8%) 7 (14%)
Mandibular, Hyperplasia, Lymphoid 2 (4%)
Mandibular, Hyperplasia, Plasma Cell 8 (16%) 7 (14%) 6 (12%)
Mandibular, Metaplasia, Osseous 1 (2%)
Mediastinal, Atrophy 1 (2%) 1 (2%)
Mediastinal, Erythrophagocytosis 2 (4%) 3 (6%) 1 (2%)
Mediastinal, Hemorrhage 6 (12%) 4 (8%) 3 (6%)
Mediastinal, Hyperplasia, Histiocytic 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Pigmentation 3 (6%) 3 (6%) 3 (6%)
Mediastinal, Lymphatic, Ectasia 1 (2%) 2 (4%) 1 (2%)
Mesenteric, Atrophy 3 (6%) 2 (4%) 5 (10%)
Mesenteric, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Hemorrhage 1 (2%) 1 (2%)
Mesenteric, Hyperplasia, Histiocytic 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Mesenteric, Hyperplasia, Plasma Cell 1 (2%)
Mesenteric, Necrosis 1 (2%)
Mesenteric, Lymphatic, Ectasia 2 (4%) 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Pigmentation 1 (2%)
Pancreatic, Lymphatic, Ectasia 1 (2%)
Renal, Pigmentation 1 (2%)
Spleen (49) (50) (50)
Atrophy 4 (8%) 3 (6%)
Congestion 1 (2%)
Degeneration, Fatty 1 (2%)
Fibrosis 4 (8%) 6 (12%) 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 1 (2%) 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation Erythrocytic 9 (18%) 8 (16%) 8 (16%)
Hyperplasia, Histiocytic 1 (2%)
Necrosis 2 (4%)
Pigmentation, Hemosiderin 2 (4%) 1 (2%) 1 (2%)
Lymphatic, Ectasia 1 (2%) 1 (2%)
Thymus (34) (29) (34)
Cyst 5 (15%) 1 (3%) 1 (3%)
Ectopic Parathyroid Gland 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (44) (46)
Angiectasis 1 (2%)
Hyperplasia, Cystic 16 (35%) 13 (30%) 12 (26%)
Hyperplasia, Lobular 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Skin (49) (49) (49)
Acanthosis 4 (8%) 3 (6%)
Cyst Epithelial Inclusion 2 (4%) 1 (2%) 1 (2%)
Edema 1 (2%)
Exudate 3 (6%)
Foreign Body 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%)
Inflammation, Chronic 3 (6%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 2 (4%)
Hyperostosis 2 (4%)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
Skeletal Muscle (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (48)
Compression 2 (4%) 1 (2%)
Degeneration, Multiple 3 (6%) 8 (16%) 4 (8%)
Necrosis 1 (2%)
Cerebellum, Mineralization 1 (2%)
Cerebrum, Degeneration 1 (2%) 1 (2%) 1 (2%)
Cerebrum, Hemorrhage 1 (2%)
Cerebrum, Necrosis 1 (2%)
Thalamus, Degeneration 1 (2%)
Thalamus, Hemorrhage 1 (2%)
Peripheral Nerve (50) (48) (48)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Lymphocyte,
Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Adenomatosis 5 (10%) 4 (8%) 3 (6%)
Edema, Diffuse 1 (2%) 2 (4%) 1 (2%)
Foreign Body 6 (12%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 28 (56%) 27 (54%) 29 (59%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Granulomatous 4 (8%) 2 (4%) 3 (6%)
Inflammation, Suppurative 2 (4%)
Metaplasia, Osseous 1 (2%)
Pigmentation 1 (2%)
Artery, Mineralization 2 (4%)
Artery, Media, Hypertrophy 2 (4%)
Parenchyma, Mineralization 1 (2%)
Nose (49) (49) (47)
Lumen, Foreign Body 2 (4%) 1 (2%)
Lumen, Fungus 4 (8%) 1 (2%) 1 (2%)
Lumen, Hemorrhage 1 (2%)
Lumen, Inflammation, Suppurative 8 (16%) 3 (6%) 7 (15%)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
Mucosa, Inflammation, Chronic 1 (2%)
Mucosa, Metaplasia, Squamous 1 (2%)
Mucosa, Necrosis 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 2 (4%) 1 (2%)
Nasopharyngeal Duct, Foreign Body 1 (2%)
Nasopharyngeal Duct, Inflammation,
Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:51:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Submucosa, Inflammation, Chronic 1 (2%) 3 (6%) 2 (4%)
Trachea (49) (49) (49)
Lumen, Exudate 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Middle Ear, Inflammation, Suppurative 1 (100%)
Eye (2) (2) (28)
Angiectasis 1 (4%)
Cataract 1 (50%) 1 (50%) 25 (89%)
Retinal Detachment 1 (4%)
Synechia 1 (4%)
Retina, Atrophy 2 (100%) 2 (100%) 28 (100%)
Harderian Gland (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hydronephrosis 3 (6%)
Inflammation, Chronic 30 (60%) 30 (60%) 27 (54%)
Inflammation, Suppurative 6 (12%) 6 (12%) 8 (16%)
Nephropathy 50 (100%) 49 (98%) 49 (98%)
Papilla, Necrosis 1 (2%)
Pelvis, Mineralization 1 (2%) 1 (2%)
Pelvis, Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Mineralization 8 (16%) 12 (24%) 6 (12%)
Renal Tubule, Pigmentation 3 (6%) 3 (6%) 2 (4%)
Ureter (1)
Dilatation 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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