National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2620

TDMS Study 05049-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             DICHLORVOS


NTP Experiment-Test: 05049-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: GAVAGE                                                                                                     Time: 02:52:19




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            3            5                                                  
    Accident                                           1                                                                            
    Moribund                                          14           21           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           26           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
      Rectum, Leiomyosarcoma                           1 (2%)                                                                       
   Intestine Small                                    (50)         (49)         (50)                                                
      Jejunum, Leiomyoma                                            1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplastic Nodule                                                          1 (2%)                                             
   Mesentery                                          (10)         (12)         (7)                                                 
   Pancreas                                           (50)         (47)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)       4 (8%)                                             
   Pharynx                                            (1)                       (2)                                                 
      Squamous Cell Carcinoma                                                    1 (50%)                                            
   Salivary Glands                                    (49)         (50)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Stomach                                            (50)         (49)         (50)                                                
      Forestomach, Squamous Cell Papilloma                          1 (2%)                                                          
   Tongue                                             (3)          (1)          (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Pheochromocytoma Benign                                       1 (2%)                                                          
      Cortex, Adenoma                                  1 (2%)       4 (8%)                                                          
      Medulla, Pheochromocytoma Malignant                                        2 (4%)                                             
      Medulla, Pheochromocytoma Benign                 4 (8%)       1 (2%)       2 (4%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Medulla, Pheochromocytoma Benign, Multiple                                 2 (4%)                                             
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)                                             
   Parathyroid Gland                                  (49)         (47)         (45)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          27 (54%)     19 (39%)     19 (38%)                                            
      Pars Distalis, Carcinoma                         1 (2%)       2 (4%)       4 (8%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)                                             
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)                                                
      C-Cell, Adenoma                                  4 (8%)       7 (14%)      5 (10%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (43)         (41)                                                
      Adenoma                                          3 (7%)       1 (2%)       3 (7%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa Cell Tumor                             2 (4%)                                                                       
      Leiomyosarcoma                                                1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                   15 (30%)     14 (28%)     13 (26%)                                            
      Sarcoma Stromal                                                            2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (2)          (3)                                                 
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (39)         (39)         (39)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        2 (4%)       2 (4%)                                                          
      Fibroadenoma                                     9 (18%)     13 (26%)     13 (27%)                                            
      Fibroadenoma, Multiple                                        6 (12%)      3 (6%)                                             
   Skin                                               (50)         (48)         (48)                                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                  1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
      Sebaceous Gland, Carcinoma                       2 (4%)                                                                       
      Subcutaneous Tissue, Fibroma                                               2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Nose                                               (50)         (49)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Papilloma                                        1 (2%)                    1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            17 (34%)     21 (42%)     23 (46%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          46          46                                                   
     Total Primary Neoplasms                           97         108         111                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          40          39                                                   
     Total Benign Neoplasms                            70          75          75                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          32          30                                                   
     Total Malignant Neoplasms                         25          33          36                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2                                                                           
     Total Uncertain Neoplasms                          2                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           17           18                                                  
    Dead                                               4            3            4                                                  
    Accident                                           1            5            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           25           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)         (50)                                                
      Cecum, Lipoma                                                 1 (2%)                                                          
      Colon, Polyp Adenomatous                                                   1 (2%)                                             
   Intestine Small                                    (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)       1 (2%)                                             
      Neoplastic Nodule                                             2 (4%)       1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Mesentery                                          (9)          (7)          (8)                                                 
      Sarcoma                                          1 (11%)                                                                      
   Pancreas                                           (50)         (49)         (50)                                                
      Adenoma                                         14 (28%)     18 (37%)     17 (34%)                                            
      Adenoma, Multiple                                2 (4%)       7 (14%)     13 (26%)                                            
   Pharynx                                            (1)          (2)          (1)                                                 
      Palate, Fibrosarcoma                                                       1 (100%)                                           
   Salivary Glands                                    (48)         (48)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Stomach                                            (50)         (49)         (50)                                                
      Forestomach, Fibrosarcoma                        1 (2%)                                                                       
      Forestomach, Squamous Cell Papilloma             2 (4%)       1 (2%)                                                          
      Glandular, Adenoma                                                         1 (2%)                                             
   Tongue                                                          (1)          (2)                                                 
      Squamous Cell Papilloma                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Cortex, Adenoma                                  1 (2%)       1 (2%)                                                          
      Medulla, Pheochromocytoma Malignant              2 (4%)       5 (10%)      4 (8%)                                             
      Medulla, Pheochromocytoma Malignant, Multiple                 1 (2%)                                                          
      Medulla, Pheochromocytoma Benign                13 (26%)     12 (24%)     12 (24%)                                            
      Medulla, Pheochromocytoma Benign, Multiple       8 (16%)      4 (8%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Adenoma                                          6 (12%)      5 (10%)      3 (6%)                                             
      Adenoma, Multiple                                             1 (2%)       2 (4%)                                             
   Parathyroid Gland                                  (45)         (46)         (47)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (49)                                                
      Pars Distalis, Adenoma                           9 (18%)     11 (23%)      7 (14%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                    2 (4%)                                             
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
   Thyroid Gland                                      (49)         (49)         (49)                                                
      C-Cell, Adenoma                                  6 (12%)      9 (18%)      7 (14%)                                            
      C-Cell, Adenoma, Multiple                                                  1 (2%)                                             
      C-Cell, Carcinoma, Multiple                                   1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (48)         (46)         (45)                                                
      Adenoma                                          2 (4%)       4 (9%)       3 (7%)                                             
      Carcinoma                                        1 (2%)                    3 (7%)                                             
   Prostate                                           (50)         (50)         (49)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Seminal Vesicle                                    (3)          (4)          (2)                                                 
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                      29 (58%)     18 (36%)     19 (38%)                                            
      Interstitial Cell, Adenoma, Multiple            16 (32%)     28 (56%)     27 (54%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Spleen                                             (49)         (50)         (50)                                                
      Fibrosarcoma                                                               1 (2%)                                             
   Thymus                                             (34)         (29)         (34)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (44)         (46)                                                
      Fibroadenoma                                     6 (13%)      1 (2%)       2 (4%)                                             
   Skin                                               (49)         (49)         (49)                                                
      Basal Cell Adenoma                                                         1 (2%)                                             
      Basal Cell Carcinoma                                          1 (2%)       2 (4%)                                             
      Carcinosarcoma                                                1 (2%)                                                          
      Keratoacanthoma                                  3 (6%)       4 (8%)       1 (2%)                                             
      Squamous Cell Papilloma                          3 (6%)       3 (6%)       2 (4%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     7 (14%)      6 (12%)      4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    2 (4%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (48)                                                
      Astrocytoma Malignant                            1 (2%)                    1 (2%)                                             
      Granular Cell Tumor Benign                                    1 (2%)                                                          
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Adenoma                                               3 (6%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Neoplasm NOS, Metastatic                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Adrenal Gland                                             1 (2%)                                                          
   Nose                                               (49)         (49)         (47)                                                
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (28)                                                
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Hamartoma                                        1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            11 (22%)     20 (40%)     21 (42%)                                            
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Mesothelioma Malignant                           3 (6%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05049-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 09/07/94  
Route: GAVAGE                                                                                                     Time: 02:52:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      4.0          8.0                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50                                                   
     Total Primary Neoplasms                          163         174         173                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          49                                                   
     Total Benign Neoplasms                           135         140         130                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          29          32                                                   
     Total Malignant Neoplasms                         28          34          43                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1                                                   
     Total Metastatic Neoplasm                          3           1           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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