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TDMS Study 05049-01 Pathology Tables

NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97
Route: GAVAGE                                                                                                     Time: 11:18:24




       Facility:  Southern Research Institute

       Chemical CAS #:  62-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|             
                                           | 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Parasite Metazoan             |                                                                         2|             
      Colon, Parasite Metazoan             |          2                                               2              2|             
      Rectum, Parasite Metazoan            |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
      Basophilic Focus                     |    X  X  X  X  X     X  X  X     X     X  X        X  X  X           X  X|             
      Clear Cell Focus                     |                                                       X                  |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                   2              2     2  2        1              1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                            2                             2               |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  2  2  2        2              4  2  2  3        1  1  2  3         |             
      Hepatocyte, Atrophy, Multifocal      |                               3                                          |             
      Hepatocyte, Cytoplasmic Alteration   |                                              3                           |             
      Hepatocyte, Hyperplasia, Nodular     |                                                                          |             
      Hepatocyte, Necrosis, Multifocal     |                                              3                           |             
      Hepatocyte, Vacuolization Cytoplasmic|       2        3              3              3                           |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           | 2        2                    4              3                           |             
      Portal, Fibrosis                     |    2  2                 2  1        4  2  2  3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +  +                    +                             +        +   |             
      Fat, Mineralization                  |       3                                                              3   |             
      Fat, Necrosis, Focal                 |       4  4                    2                             3        4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                             2               |             
      Cyst                                 |                   X                                                      |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
      Palate, Inflammation, Suppurative    |                3                                                         |             
      Palate, Necrosis                     |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Diverticulum            |                                                                          |             
      Forestomach, Edema                   |       3                                                                  |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|             
                                           | 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Ulcer                   | 3     3        3                                                         |             
      Forestomach, Mucosa, Dysplasia       |                                                                          |             
      Forestomach, Mucosa, Hyperplasia     |    2  3        3              2                                          |             
      Glandular, Dysplasia                 |                                                                          |             
      Glandular, Edema                     |       3                                                                  |             
      Glandular, Erosion                   |                3                             2                           |             
      Glandular, Mineralization            |                                                          2        2      |             
      Glandular, Ulcer                     |                                                             3            |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |             3  2              2  2     2  2        2     2  2     3     3|             
      Myocardium, Inflammation, Chronic    |          2  3  3                                                         |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Eosinophil    |                               2                                          |             
      Inflammation, Chronic                |    2                                   3                                 |             
      Cortex, Congestion                   |                                                                          |             
      Cortex, Cyst                         |                                                          X               |             
      Cortex, Hyperplasia                  |                                                                          |             
      Cortex, Necrosis                     | 3                                                                        |             
      Cortex, Pigmentation                 |    3                                                                     |             
      Cortex, Vacuolization Cytoplasmic    |       2        2                                                  2      |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                           1                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          X  X  X        X  X        X        X        X              X   |             
      Pars Distalis, Hyperplasia           |             2           2           2                                    |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          3               |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2     3                 3     2        2        2     3           2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|             
                                           | 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    3              4      |             
      Hyperplasia                          |                                                       4           4      |             
      Inflammation, Suppurative            |                                  2                 2  2           3     2|             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X  X  X  X                                               X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                       3                  |             
      Hydrometra                           |                                                                      2   |             
      Inflammation, Suppurative            |                2                       2                                 |             
      Mucosa, Hyperplasia                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +              +              +                           |             
      Inflammation, Suppurative            |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                   3      |             
      Hyperplasia, Reticulum Cell          |                   2     1                                3               |             
      Myelofibrosis                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Axillary, Inflammation, Suppurative  |                                                                          |             
      Axillary, Lymphatic, Ectasia         |                                                                          |             
      Bronchial, Hemorrhage                |                   2                                                      |             
      Bronchial, Infiltration Cellular,    |                                                                          |             
           Mast Cell                       |                   3                                                      |             
      Lymphatic, Mandibular, Ectasia       |             2                                                            |             
      Mandibular, Hyperplasia, Plasma Cell |    2                                            3                        |             
      Mediastinal, Erythrophagocytosis     |                                                    3                 3   |             
      Mediastinal, Hemorrhage              |                   2                                         3            |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                   3                                                      |             
      Mediastinal, Pigmentation            |    2     3           3                 2  3              3           3   |             
      Mesenteric, Atrophy                  |                                                                          |             
      Mesenteric, Erythrophagocytosis      |                                                                          |             
      Mesenteric, Hemorrhage               |                3                                                         |             
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                3        3                                                |             
      Mesenteric, Pigmentation             |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|             
                                           | 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              4                           |             
      Erythrophagocytosis                  |                                                                          |             
      Fibrosis                             |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       3                                                           3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |       2                                                           3      |             
      Pigmentation, Hemosiderin            |    3           3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  3     3  1  2  2     2  2  2  3     1  2  4  2     2     2  4  1  1|             
      Hyperplasia, Lobular                 |                                                                          |             
      Inflammation, Suppurative            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       2           2                                                      |             
      Degeneration, Multiple               |    3        2  3     2                                                   |             
      Hydrocephalus                        |                                  2                                       |             
      Cerebrum, Degeneration               |       1                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                      2                                                   |             
      Edema, Diffuse                       | 3                                                                        |             
      Fibrosis                             |                                                                      2   |             
      Foreign Body                         |    4                                                                     |             
      Hemorrhage                           |                                                          3              3|             
      Infiltration Cellular, Histiocyte    |    2  2     2     1  2  1  2  1     2  2  1  1  1  1  1  1  1     1  1  4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|             
                                           | 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2     2                          2                              |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                        M         |             
      Cataract                             |       4                                                                  |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  1        2        2                     |             
      Inflammation, Suppurative            |                                                    2                     |             
      Nephropathy                          | 1  2  1     1  1     1  1        1        2  2  1  1  1  1        1     1|             
      Pelvis, Mineralization               |    1     2  1  2     2                 1        1  2                     |             
      Renal Tubule, Mineralization         |                                           2           1  1        1      |             
      Renal Tubule, Necrosis               |                                     4                                    |             
      Renal Tubule, Pigmentation           |    3           2  2           3  2                 2              2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Hyperplasia                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Parasite Metazoan             |                                  2                                       |      2  2.0|
      Colon, Parasite Metazoan             |                               2           2                              |      5  2.0|
      Rectum, Parasite Metazoan            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 1     2                  |      3  2.0|
      Basophilic Focus                     |             X  X  X  X  X  X     X  X  X  X        X  X  X        X  X  X|     32     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |       2                          2                                       |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
      Inflammation, Chronic                |                                           3                              |      8  1.8|
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Inflammation, Granulomatous          |          1              2  2              2  4  2  1           2     3   |     11  2.1|
      Mixed Cell Focus                     |                X                                                         |      1     |
      Bile Duct, Hyperplasia               |    2        2        2        2  2  2  2  2     1  1  2        1     2   |     27  2.0|
      Hepatocyte, Atrophy, Multifocal      |                               3              2        2        2         |      5  2.4|
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      1  3.0|
      Hepatocyte, Hyperplasia, Nodular     |             3                                            3               |      2  3.0|
      Hepatocyte, Necrosis, Multifocal     |       1                                                                  |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|    4                             2                                       |      6  2.8|
      Kupffer Cell, Hyperplasia            |                2                                                         |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                                          |      4  2.8|
      Portal, Fibrosis                     |                1              2     1                       2        2   |     13  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                 +                    +           +      |  10        |
      Fat, Mineralization                  |                3                                                  4      |      4  3.3|
      Fat, Necrosis, Focal                 |                3                 4                    4           4      |      9  3.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1        1                                                  2   |      5  1.6|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                2         |      1  2.0|
      Hyperplasia                          |                            3                                2            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Palate, Necrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |             2     2                                                      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Diverticulum            |                                        X                                 |      1     |
      Forestomach, Edema                   |                                                                          |      1  3.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Forestomach, Ulcer                   |                                                                3  4      |      5  3.2|
      Forestomach, Mucosa, Dysplasia       |                                                                3         |      1  3.0|
      Forestomach, Mucosa, Hyperplasia     |                                                                3         |      5  2.6|
      Glandular, Dysplasia                 |                                                                   2      |      1  2.0|
      Glandular, Edema                     |                                                                          |      1  3.0|
      Glandular, Erosion                   | 3                                                                        |      3  2.7|
      Glandular, Mineralization            |             2  3  2                                                      |      5  2.2|
      Glandular, Ulcer                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                 +        +               |   3        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
      Epithelium, Hyperplasia              |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Fibrosis                 |          3        3  2           2        2           3  2              2|     19  2.3|
      Myocardium, Inflammation, Chronic    |                                     1     2  2                       1  2|      8  2.0|
      Myocardium, Mineralization           |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      3   |      1  3.0|
      Infiltration Cellular, Eosinophil    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Cortex, Congestion                   | 4                                                                        |      1  4.0|
      Cortex, Cyst                         |                                        X                                 |      2     |
      Cortex, Hyperplasia                  | 4                                         2                    2  2     2|      5  2.4|
      Cortex, Necrosis                     |                                                                          |      1  3.0|
      Cortex, Pigmentation                 |                                                                          |      1  3.0|
      Cortex, Vacuolization Cytoplasmic    | 4                          1              2  2           2        2      |      9  2.1|
      Medulla, Hyperplasia, Focal          |                                                    2     2        1      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                1     3                                                   |      2  2.0|
      Pars Distalis, Cyst                  |    X     X           X              X  X  X     X        X               |     17     |
      Pars Distalis, Hyperplasia           |                      2                                                   |      4  2.0|
      Pars Intermedia, Cyst                |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ultimobranchial Cyst                 |                                           X        X                     |      2     |
      C-Cell, Hyperplasia                  |                   2                       2     2  1           3  3      |     15  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Ectasia                              |          3                 4                                             |      4  3.5|
      Hyperplasia                          |                                  2                                       |      3  3.3|
      Inflammation, Suppurative            |       2                 2  3                                             |      8  2.3|
      Metaplasia, Squamous                 |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       X                  |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                 3                        |      2  3.0|
      Hydrometra                           |                                        2  3                              |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                        +                                 |   4        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                             +            |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  3                                       |      3  2.7|
      Hyperplasia, Reticulum Cell          |                         3  3              3              2           4   |      8  2.6|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Lymphoid      |                                                          3               |      1  3.0|
      Axillary, Inflammation, Suppurative  |                                                          3               |      1  3.0|
      Axillary, Lymphatic, Ectasia         |                                                          4               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Bronchial, Hemorrhage                |                                                 3                        |      2  2.5|
      Bronchial, Infiltration Cellular,    |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|
      Lymphatic, Mandibular, Ectasia       |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Plasma Cell |                   3                                               3      |      4  2.8|
      Mediastinal, Erythrophagocytosis     |                3                                                         |      3  3.0|
      Mediastinal, Hemorrhage              | 3     3        3                                                         |      5  2.8|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                   3      |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                      3  3                                               3|     10  2.8|
      Mesenteric, Atrophy                  |                4                                               3     3   |      3  3.3|
      Mesenteric, Erythrophagocytosis      |                4                                                         |      1  4.0|
      Mesenteric, Hemorrhage               |                                                                2         |      2  2.5|
      Mesenteric, Hyperplasia, Histiocytic |                                  2                                       |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      2  3.0|
      Mesenteric, Pigmentation             |                                                                      3   |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Erythrophagocytosis                  |                3                                                         |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                          3               |      3  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |       3                 2  2     3                       3               |      7  2.6|
      Pigmentation, Hemosiderin            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 4  2  3  2  3  2  3  2        2  3  3  2  2  2     2  1  4  2  3  2     1|     41  2.3|
      Hyperplasia, Lobular                 |                            2                                   3         |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                2     4                                                   |      2  3.0|
      Hyperkeratosis                       |                      4                                                   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.0|
      Degeneration, Multiple               |                   3     3                                         3      |      7  2.7|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Cerebrum, Degeneration               |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                1                       3                                 |      3  2.0|
      Edema, Diffuse                       |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  4.0|
      Hemorrhage                           | 3                                                                        |      3  3.0|
      Infiltration Cellular, Histiocyte    | 2              1  2  1  2  1     1  1     2     1  1  1           1  1  1|     35  1.4|
      Inflammation, Chronic                |                                           2                              |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Fungus                        | 2        3                                                               |      2  2.5|
      Lumen, Inflammation, Suppurative     | 3        3                                                           1   |      3  2.3|
      Mucosa, Metaplasia, Squamous         | X                                                                    2   |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      3  2.0|
      Submucosa, Inflammation, Chronic     |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +     M            |   2        |
      Cataract                             |                                                       3                  |      2  3.5|
      Retina, Atrophy                      |                                                       3                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3|            |
                                           | 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                2         |      4  1.8|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy                          | 3           1  1  1  1     2     1  2  1     2  1  2  2  1     2  1  1  1|     34  1.3|
      Pelvis, Mineralization               |       2                    1        2              2              1      |     13  1.5|
      Renal Tubule, Mineralization         |                                                                          |      4  1.3|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |                                                    2                     |      8  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                       2                  |      1  2.0|
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|             
                                           | 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0                                    | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Parasite Metazoan             |                                                                          |             
      Colon, Parasite Metazoan             |                         1                       2  2                     |             
      Colon, Serosa, Cyst                  |                                                                          |             
      Rectum, Parasite Metazoan            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Jejunum, Developmental Malformation  |                                                                   X      |             
      Jejunum, Hemorrhage                  |                                                                          |             
      Jejunum, Hyperplasia, Re Cell        |                                                          3               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |             X  X  X  X     X  X     X  X  X  X  X  X  X  X     X  X  X   |             
      Clear Cell Focus                     |                                           X     X                        |             
      Developmental Malformation           |             X                                                  X         |             
      Inflammation, Chronic                |                   2     1              2        2  2                     |             
      Inflammation, Granulomatous          |             2     2        3              3              1     1     1   |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |          2                       3  2                 2        2  3     4|             
      Capsule, Fibrosis                    |          2                                                               |             
      Hepatocyte, Atrophy, Multifocal      |       3  3                       3  3                             2     2|             
      Hepatocyte, Hyperplasia, Nodular     |                                                                          |             
      Hepatocyte, Necrosis, Multifocal     |                                     1                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|                               2                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                               2                                          |             
      Kupffer Cell, Pigmentation           |       4                                                                 3|             
      Portal, Fibrosis                     |                                     2                 2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +              +                    +              +|             
      Ectopic Tissue                       |                                                                          |             
      Fat, Fibrosis                        |                                     3                                    |             
      Fat, Mineralization                  |                                     3                    3              3|             
      Fat, Necrosis, Focal                 |                      3              4                    3              4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  3     2                          1     3  3                       1|             
                                            __________________________________________________________________________|             
   Pharynx                                 | +                                                                        |             
      Palate, Inflammation, Suppurative    |                                                                          |             
      Palate, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Inflammation,           |                                                                          |             
          Suppurative                      |                                                             2            |             
      Forestomach, Ulcer                   |                                                                3         |             
      Forestomach, Mucosa, Dysplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|             
                                           | 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0                                    | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Mucosa, Hyperplasia     |                               2                                2         |             
      Glandular, Erosion                   |                               3                             4            |             
      Glandular, Mineralization            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |                            2           2  2        3  2  3     2         |             
      Myocardium, Inflammation, Chronic    |                   1  1                                                   |             
      Myocardium, Pigmentation             |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                        3                                 |             
      Cortex, Congestion                   |    3                                                                     |             
      Cortex, Cytoplasmic Alteration,      |                                                                          |             
          Diffuse                          |    4                                                                     |             
      Cortex, Hematocyst                   |                                                                          |             
      Cortex, Hyperplasia                  |                                                    3           2         |             
      Cortex, Necrosis                     |                                                             2            |             
      Cortex, Vacuolization Cytoplasmic    |       2        2        2        2     3                          3      |             
      Extra Adrenal Tissue, Developmental  |                                                                          |             
          Malformation                     |                                                                          |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            2                 4                           |             
      Pars Distalis, Cyst                  | X     X  X     X     X                                         X  X     X|             
      Pars Distalis, Hyperplasia           |       2        2           2                                      2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2                                         1        1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Ectasia                              |                   3                                      3               |             
      Hyperplasia                          |                                           4                       3      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             2     2                       4                       3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|             
                                           | 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0                                    | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                 X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                        3     4           4               |             
      Cyst                                 |                X                                                         |             
      Hydrometra                           |                                                 2                    2   |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                2                                                         |             
      Prolapse                             |                                                                          |             
      Endometrium, Dysplasia               |                                                       2                  |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +     +                                      +        M  M           M|             
      Abscess                              |    3                                                                     |             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +     +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                      2      |             
      Hyperplasia, Reticulum Cell          |                                        4        1                        |             
      Myelofibrosis                        |       2                                                                 3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lymphatic, Mandibular, Ectasia       |                                                                3         |             
      Mandibular, Hyperplasia, Histiocytic |                                                    3                     |             
      Mandibular, Hyperplasia, Plasma Cell |                                  3                 3     2     3         |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                          2               |             
      Mediastinal, Erythrophagocytosis     |             2                                                            |             
      Mediastinal, Hemorrhage              |                      3     2              3        2  2                  |             
      Mediastinal, Hyperplasia, Histiocytic|                         3                                                |             
      Mediastinal, Pigmentation            |             3              2     3                 3  3                  |             
      Mesenteric, Atrophy                  |                3                                3              3         |             
      Mesenteric, Hemorrhage               |                                        4                                 |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                                          |             
      Mesenteric, Lymphatic, Ectasia       |                                                                   3      |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                         2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|             
                                           | 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0                                    | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Granulocytic                     |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                            2        2  2  2              2  4            |             
      Hemorrhage                           |                                  4                                       |             
      Necrosis                             |          4                       4                                       |             
      Pigmentation, Hemosiderin            |                               4                 2  3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Cystic                  |       2  2        2        2  4  3  2  2  2     1  3  2  3  2            |             
      Hyperplasia, Lobular                 |       3                                3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     3                                    |             
      Inflammation, Chronic                |                                     2                                    |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                  3                             3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                             2        3                              |             
      Degeneration, Multiple               |                                                    3           3         |             
      Cerebrum, Degeneration               |                                              2                    1      |             
      Thalamus, Degeneration               |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                        1                                 |             
      Infiltration Cellular, Histiocyte    |       1  2  2  1  3  2  2  3     3  2  2  2  2  1  2  3  2  2  2  2  3  2|             
      Inflammation, Suppurative            |                                                    1                     |             
      Mineralization                       |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                    3           2         |             
      Lumen, Fungus                        |                            3                                   2         |             
      Lumen, Inflammation, Suppurative     |                            3                       2           2         |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|             
                                           | 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0                                    | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +  M            |             
      Cataract                             |                                                          4               |             
      Retinal Detachment                   |                                                          3               |             
      Retina, Atrophy                      |                                                          3               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Suppurative            |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                           2                              |             
      Nephropathy                          |          2  1  1  2     1  1  1  1     1  3     1  1  1  1  2     1  1   |             
      Pelvis, Mineralization               |             2  1        3        1  1                 1  1     1         |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |       2                 2                                   2           2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3|            |
                                           | 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Parasite Metazoan             |                                                       2                  |      1  2.0|
      Colon, Parasite Metazoan             |    2           2     2     2           2                                 |      8  1.9|
      Colon, Serosa, Cyst                  |                   X                                                      |      1     |
      Rectum, Parasite Metazoan            |                      2     2           2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Jejunum, Developmental Malformation  |                                                                          |      1     |
      Jejunum, Hemorrhage                  |                   2                                                      |      1  2.0|
      Jejunum, Hyperplasia, Re Cell        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2                     |      1  2.0|
      Basophilic Focus                     |          X  X        X  X           X              X  X                  |     24     |
      Clear Cell Focus                     |                                                                          |      2     |
      Developmental Malformation           |                                                                          |      2     |
      Inflammation, Chronic                |       2                                                                  |      6  1.8|
      Inflammation, Granulomatous          |             2           1  2           2           1              1      |     13  1.7|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Bile Duct, Hyperplasia               |       2     1                             2  2  2  2  2        2     2  2|     17  2.2|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
      Hepatocyte, Atrophy, Multifocal      |                               2        2  3                 2        3   |     11  2.5|
      Hepatocyte, Hyperplasia, Nodular     |          2                                               3  2            |      3  2.3|
      Hepatocyte, Necrosis, Multifocal     |                                                                3         |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                3                                3           2     2      |      5  2.4|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                                          |      2  3.5|
      Portal, Fibrosis                     |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +                                   +      |   7        |
      Ectopic Tissue                       |          X                                                               |      1     |
      Fat, Fibrosis                        |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      3  3.0|
      Fat, Necrosis, Focal                 |                               4                                   3      |      6  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3                    4     2     1     2     2                 2  1|     15  2.1|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |             +                                                            |   2        |
      Palate, Inflammation, Suppurative    |             4                                                            |      1  4.0|
      Palate, Necrosis                     |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                                                         X|      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3|            |
                                           | 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Forestomach, Ulcer                   |                4  4                                                      |      3  3.7|
      Forestomach, Mucosa, Dysplasia       |    3                    1                                                |      2  2.0|
      Forestomach, Mucosa, Hyperplasia     |    3              2                             2                 2      |      6  2.2|
      Glandular, Erosion                   |                                                                          |      2  3.5|
      Glandular, Mineralization            |       2                                                           1      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Fibrosis                 |                         2                                               2|      9  2.2|
      Myocardium, Inflammation, Chronic    |                                     1                                    |      3  1.0|
      Myocardium, Pigmentation             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Cortex, Congestion                   |                                                                          |      1  3.0|
      Cortex, Cytoplasmic Alteration,      |                                                                          |            |
          Diffuse                          |                                                                          |      1  4.0|
      Cortex, Hematocyst                   |                   X                                                      |      1     |
      Cortex, Hyperplasia                  |             3        3              2        3                    3      |      7  2.7|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Cortex, Vacuolization Cytoplasmic    |    2              2                       2     3           3           2|     12  2.3|
      Extra Adrenal Tissue, Developmental  |                                                                          |            |
          Malformation                     |                                        X                                 |      1     |
      Medulla, Hyperplasia, Focal          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |             2                    4     2        2                        |      6  2.7|
      Pars Distalis, Cyst                  |       X                 X     X     X  X     X        X        X         |     16     |
      Pars Distalis, Hyperplasia           |                         1              3                                 |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          2  1                 2        2  3           3                  |     10  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3|            |
                                           | 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Dysplasia                            |                                  3                                       |      1  3.0|
      Ectasia                              |                                                                         2|      3  2.7|
      Hyperplasia                          |                      3           4  2                                    |      5  3.2|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Inflammation, Suppurative            |                      3           4                                   4   |      7  3.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             X  X              X  X                                       |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |          4                 3                                      3      |      6  3.5|
      Cyst                                 |                                                                          |      1     |
      Hydrometra                           |                                     2                                    |      3  2.0|
      Hyperplasia, Cystic                  | 2                                      3                                 |      2  2.5|
      Hyperplasia, Glandular               |                                                                2         |      1  2.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Prolapse                             | X                                                                        |      1     |
      Endometrium, Dysplasia               |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                  +              +                    +   |   7        |
      Abscess                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                           +                              |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Hyperplasia, Reticulum Cell          |    3                                   4           2                     |      5  2.8|
      Myelofibrosis                        |                                           2  2                       2   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                      2   |      1  2.0|
      Lymphatic, Mandibular, Ectasia       |                      2                                                   |      2  2.5|
      Mandibular, Hyperplasia, Histiocytic |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |             3  3                                2                        |      7  2.7|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      1  2.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                       3                  |      6  2.5|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3|            |
                                           | 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Pigmentation            |       3  3                                            3  3     3         |     10  2.9|
      Mesenteric, Atrophy                  |                               3                          3               |      5  3.0|
      Mesenteric, Hemorrhage               |                                              2                           |      2  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                       3                  |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                               2                                          |      1  2.0|
      Mesenteric, Lymphatic, Ectasia       |                                  4                                       |      2  3.5|
      Pancreatic, Hemorrhage               |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                  3                                       |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     | 2                                      2           2                     |      9  2.2|
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      2  4.0|
      Pigmentation, Hemosiderin            |                   3                                                      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                               2                                          |      1  2.0|
      Hyperplasia, Cystic                  |    4  2  2  2  2  2        2  2  3  2     3  1  2  2  2  3  2  2  3  3  2|     35  2.3|
      Hyperplasia, Lobular                 |                                     3                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                               2                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    4                                                                     |      4  3.0|
      Degeneration, Multiple               |             2                                                  3        3|      5  2.8|
      Cerebrum, Degeneration               |                   2              2                                       |      4  1.8|
      Thalamus, Degeneration               |                   2              2                                       |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3|            |
                                           | 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |             2                                3                           |      3  2.0|
      Infiltration Cellular, Histiocyte    |    3  2  2  2  2  2  2  2  2  2  2  2  3  3  1  2  2  3  2  1  3  1  1  2|     46  2.1|
      Inflammation, Suppurative            |                                                                2         |      2  1.5|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumen, Foreign Body                  |                                                                          |      2  2.5|
      Lumen, Fungus                        |                                                                      2   |      3  2.3|
      Lumen, Inflammation, Suppurative     |                                                                      2   |      4  2.3|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                 3                        |      1  3.0|
      Submucosa, Inflammation, Chronic     |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                           +            |   3        |
      Cataract                             |                                                                          |      1  4.0|
      Retinal Detachment                   |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         X|      1     |
      Inflammation, Chronic                |    3     2                                                               |      3  2.3|
      Nephropathy                          |    3  1  2  2  2     1  1  1           1  1  1  1  1     1  1     1  1  2|     35  1.3|
      Pelvis, Mineralization               | 1                    1  1        2              2  1  2        1     1  1|     18  1.3|
      Pelvis, Epithelium, Hyperplasia      |                                                 2                        |      1  2.0|
      Renal Tubule, Mineralization         |       1                             2     1                              |      3  1.3|
      Renal Tubule, Pigmentation           |                   2                                                      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|             
                                           | 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Mineralization                |                      3                                                   |             
      Colon, Parasite Metazoan             |                                                       1                  |             
      Rectum, Parasite Metazoan            |                                                 2                 2      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Ectopic Tissue             |                                                    X                     |             
      Duodenum, Ulcer                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X  X  X  X  X  X  X     X  X  X  X     X  X     X     X  X     X|             
      Clear Cell Focus                     |                                        X        X  X                     |             
      Developmental Malformation           |    X                                                                     |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Inflammation, Chronic                |                         2        2                                       |             
      Inflammation, Chronic Active         |                                           2                              |             
      Inflammation, Granulomatous          |          2              2        2        2              1           2   |             
      Bile Duct, Hyperplasia               | 3  2  2  2  2        2  1  2  3     2  2     2  2  1           1     1  2|             
      Hepatocyte, Atrophy, Multifocal      |       3              2              2                 2           2     2|             
      Hepatocyte, Cytoplasmic Alteration   |                                                             2            |             
      Hepatocyte, Hyperplasia, Nodular     |                               3                       3           2      |             
      Hepatocyte, Necrosis, Multifocal     |    3                 2                                3                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                   2           3                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Portal, Fibrosis                     |                                     2           1  2  3        1         |             
      Vein, Thrombosis                     | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +              +  +     +                 +        +         |             
      Inflammation, Granulomatous          |                            3                                             |             
      Inflammation, Suppurative            |                            2                                             |             
      Fat, Hemorrhage                      |                               3                                          |             
      Fat, Mineralization                  |                                                       3                  |             
      Fat, Necrosis, Focal                 | 3           3              2  3     3                 3        2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |          1              1                    3              2            |             
      Hyperplasia                          |                                  2              2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Hyperplasia, Focal    |                                                                          |             
      Parotid Gland, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                3         |             
      Forestomach, Foreign Body            |                                                                         3|             
      Forestomach, Granuloma               |                                                                         4|             
      Forestomach, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|             
                                           | 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Ulcer                   |                   3                                            2         |             
      Forestomach, Mucosa, Hyperplasia     |                   2                                            2         |             
      Glandular, Dysplasia                 |                                                                          |             
      Glandular, Erosion                   |       2                       1                                          |             
      Glandular, Inflammation, Suppurative | 2                                                                        |             
      Glandular, Mineralization            |          1        1  2  2              1        2                 2     3|             
      Glandular, Ulcer                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Epithelium, Hyperplasia              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Myocardium, Fibrosis                 |          2  2  2                 3              2  2                 2   |             
      Myocardium, Hemorrhage               |                                                                          |             
      Myocardium, Inflammation, Chronic    |                2        1  1                       2                     |             
      Myocardium, Pigmentation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Inflammation, Chronic                |                   2                                                      |             
      Cortex, Hyperplasia                  |                                                                          |             
      Cortex, Vacuolization Cytoplasmic    |                2  3           3                                      3  2|             
      Extra Adrenal Tissue, Developmental  |                                                                          |             
          Malformation                     |          X                                X                              |             
      Medulla, Hyperplasia, Focal          |    2                    3                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2                                            2         |             
      Pars Distalis, Cyst                  | X  X  X     X     X              X     X  X     X        X     X         |             
      Pars Distalis, Hyperplasia           |    3        2                             2              2               |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Infiltration        |                                                                          |             
          Cellular                         |                                                 3                        |             
      Pars Nervosa, Hemorrhage             |                                                                          |             
      Pars Nervosa, Infiltration Cellular  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                 2        1                    1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|             
                                           | 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Ectasia                              |                            3           2                                 |             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Chronic                |                            2                                             |             
      Inflammation, Suppurative            |                         2  2                                      2  2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                       X              X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                               X        X  X  X                           |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                               2                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +     +           +           +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +        +                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
      Hyperplasia                          |                3                                                         |             
      Hyperplasia, Reticulum Cell          |                      4  3                 2                       4  2   |             
      Myelofibrosis                        |    4  4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                         2                                                |             
      Mandibular, Hyperplasia, Plasma Cell | 3                                                                    2   |             
      Mediastinal, Hemorrhage              |                      2                 2           2                     |             
      Mediastinal, Pigmentation            | 3     3                             3  3                             3   |             
      Mesenteric, Atrophy                  |                                                                3         |             
      Mesenteric, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                               X                                          |             
      Fibrosis                             |                      3                                2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                4  3     2                                         3      |             
      Necrosis                             |                                              3                           |             
      Pigmentation, Hemosiderin            |                      3                                3        3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  M  +  M  +  +  M  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  1  2  2  2  3  2  2  3  2  2  2  2  2  2  3  1  2  3  2  2  3     2  2|             
      Hyperplasia, Lobular                 |       3        3        3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|             
                                           | 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Exudate                              |                   1                                                      |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperostosis                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration, Multiple               |       2                                                        3        2|             
      Hydrocephalus                        |                                                                          |             
      Cerebrum, Degeneration               |                                              1                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                   1      |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2  2  2  2  2  2  2     3  3  2  2     1  1  2  1  3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                 2                    2   |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                             2            |             
      Submucosa, Inflammation, Chronic     |                                        2        2                 2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +     +  +     +        +  +     +  +     +  +  +  +|             
      Angiectasis                          |       3           2                                                      |             
      Cataract                             | 3  2  3  3  3  3  2  3     3  3     3        2  3     3  3     2  3  3  3|             
      Hemorrhage                           |          3                    4                                          |             
      Cornea, Inflammation, Chronic        |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|             
                                           | 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4.0                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Mineralization               |                            1                                             |             
      Retina, Atrophy                      | 3  3  3  3  3  3  3  3     3  4     3        3  3     3  3     3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                      3   |             
      Inflammation, Chronic                |                                           2                              |             
      Nephropathy                          |    1     1     1  1  2  1  1  1  1  1  1  1     1  1  1  1        1  3  1|             
      Pelvis, Mineralization               |    1     1     1     2  1     2     1  1     1  1              2         |             
      Pelvis, Epithelium, Hyperplasia      |                                           2                              |             
      Renal Tubule, Mineralization         |                                  1                    1  1        2  1   |             
      Renal Tubule, Pigmentation           | 2     2        2                                      2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2|            |
                                           | 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4.0                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Colon, Mineralization                |                                                                          |      1  3.0|
      Colon, Parasite Metazoan             |                                                                          |      1  1.0|
      Rectum, Parasite Metazoan            |                                                       2                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duodenum, Ectopic Tissue             |                                                                          |      1     |
      Duodenum, Ulcer                      |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X     X           X  X        X  X              X  X        X  X   |     27     |
      Clear Cell Focus                     |          X  X              X                                             |      6     |
      Developmental Malformation           |                               X                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |       1                    1           2        2        2               |      7  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |       2     1                          2                 2               |     10  1.8|
      Bile Duct, Hyperplasia               |    2     2     2  3                 1              3  3     3  2  3  1  2|     29  2.0|
      Hepatocyte, Atrophy, Multifocal      |    3     2        3                                3  3                 3|     12  2.5|
      Hepatocyte, Cytoplasmic Alteration   |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia, Nodular     |          2                                                              3|      5  2.6|
      Hepatocyte, Necrosis, Multifocal     |                                                                          |      3  2.7|
      Hepatocyte, Vacuolization Cytoplasmic|    3                          4              2  3           3            |      7  2.9|
      Kupffer Cell, Pigmentation           |                   3                                                      |      1  3.0|
      Portal, Fibrosis                     |       1                                   1        2     2  3  1  2  1   |     13  1.7|
      Vein, Thrombosis                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +     +                       +        +                  |  12        |
      Inflammation, Granulomatous          |                                                       3                  |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Fat, Hemorrhage                      |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |             4  4     4                       3        4                  |     12  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Atrophy                              |       2        2                                                         |      6  1.8|
      Hyperplasia                          |                                                                1         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parotid Gland, Hyperplasia, Focal    |                               2                                          |      1  2.0|
      Parotid Gland, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2|            |
                                           | 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4.0                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Edema                   |                      3           4           2                           |      4  3.0|
      Forestomach, Foreign Body            |                                                                          |      1  3.0|
      Forestomach, Granuloma               |                                                                          |      1  4.0|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                              2                           |      1  2.0|
      Forestomach, Ulcer                   |                      4        3  4                             4         |      6  3.3|
      Forestomach, Mucosa, Hyperplasia     |                      3           3              1              3         |      6  2.3|
      Glandular, Dysplasia                 |    1                                                                     |      1  1.0|
      Glandular, Erosion                   |    2                 1                                                   |      4  1.5|
      Glandular, Inflammation, Suppurative |                                                                          |      1  2.0|
      Glandular, Mineralization            |                                     3                    1              2|     11  1.8|
      Glandular, Ulcer                     |                               3                 2              2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                       X                  |      1     |
      Myocardium, Fibrosis                 |       3     2        2  2        3  2  1  2              2        2  2   |     18  2.1|
      Myocardium, Hemorrhage               |       1                                                                  |      1  1.0|
      Myocardium, Inflammation, Chronic    |       2              2           2                       1           1   |      9  1.6|
      Myocardium, Pigmentation             |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Cortex, Hyperplasia                  |                                                                      3   |      1  3.0|
      Cortex, Vacuolization Cytoplasmic    |    3  1     2              1     1  2     2        2  2        1     2  3|     17  2.1|
      Extra Adrenal Tissue, Developmental  |                                                                          |            |
          Malformation                     |                                                                          |      2     |
      Medulla, Hyperplasia, Focal          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|  47        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                     2     2                              |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2|            |
                                           | 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4.0                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |       X     X     X              X        X           X     X           X|     19     |
      Pars Distalis, Hyperplasia           |                                           2                              |      5  2.2|
      Pars Distalis, Pigmentation          |                                           3                              |      1  3.0|
      Pars Intermedia, Infiltration        |                                                                          |            |
          Cellular                         |                                                                          |      1  3.0|
      Pars Nervosa, Hemorrhage             |                   2                                                      |      1  2.0|
      Pars Nervosa, Infiltration Cellular  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |       1     2           2        1                                2      |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  43        |
      Ectasia                              |       3                          2  3                                    |      5  2.6|
      Hyperplasia                          |       2                                4                                 |      3  2.3|
      Inflammation, Chronic                |                                        4                                 |      2  3.0|
      Inflammation, Suppurative            |       4                                4                                 |      6  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                           X                              |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |       4     4        4                                                   |      4  4.0|
      Atrophy                              |                                                                   3      |      1  3.0|
      Cyst                                 |                                     X                                    |      5     |
      Hydrometra                           |                            2                                             |      1  2.0|
      Hyperplasia, Cystic                  |    2  2                 2                                   2           2|      6  2.0|
      Mucosa, Hyperplasia                  |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                  +                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      5  3.0|
      Myelofibrosis                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2|            |
                                           | 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4.0                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Hyperplasia, Plasma Cell |             3                          3              2                  |      5  2.6|
      Mediastinal, Hemorrhage              |                3        2                                                |      5  2.2|
      Mediastinal, Pigmentation            |                      3                 3                          3      |      8  3.0|
      Mesenteric, Atrophy                  |                3                 3              3                        |      4  3.0|
      Mesenteric, Hemorrhage               |                         4        2                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |             3     3                                         2            |      5  2.6|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |          3                          2  3                                 |      7  2.9|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                  3                             3         |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +|  39        |
      Atrophy                              |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    2  1  2        2     2  2  2  2     2  2     2  2  2  2  2  2  3  2  2|     43  2.1|
      Hyperplasia, Lobular                 |                                        3           3                     |      5  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                                     3                                    |      1  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Exudate                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                     2                                    |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                      X   |      1     |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Hyperostosis                         |                                        3                                 |      1  3.0|
      Hyperplasia                          |                4                                                         |      1  4.0|
      Necrosis                             |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               3                 3        3        3  3   |      5  3.0|
      Degeneration, Multiple               |                      3           3     1                       2         |      7  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2|            |
                                           | 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4.0                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        |                                                          2               |      1  2.0|
      Cerebrum, Degeneration               |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |    2  1  1  2     1  1  2  1     2  1  2  1     2  2  1  2               |     39  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Foreign Body                  |                                           2                              |      1  2.0|
      Lumen, Fungus                        |                                              2                           |      1  2.0|
      Lumen, Inflammation, Suppurative     |                                           2  2                           |      4  2.0|
      Mucosa, Metaplasia, Squamous         |                                              3                           |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Submucosa, Inflammation, Chronic     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +     M        +                             +  M           +|  23        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cataract                             |             3              3                             2              2|     23  2.7|
      Hemorrhage                           |                                                                          |      2  3.5|
      Cornea, Inflammation, Chronic        |                                                                          |      1  1.0|
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Retina, Atrophy                      |             3              3                             3              3|     23  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |          1                                                               |      2  1.5|
      Nephropathy                          |    1  1  1  1        1  1  2  2  2  1     1     2     1  2  1  1  1  1  1|     38  1.2|
      Pelvis, Mineralization               |                      2  2           2  1  2           2  3           2   |     19  1.6|
      Pelvis, Epithelium, Hyperplasia      |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |             1        2  1  2                                   1     2  1|     12  1.3|
      Renal Tubule, Pigmentation           |       2                          2                                       |      6  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Parasite Metazoan             |          1  1                                                            |             
      Colon, Mineralization                |                                                                          |             
      Colon, Parasite Metazoan             |    1                    2           2  2                       2         |             
      Rectum, Parasite Metazoan            |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Jejunum, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                       3  2        2         |             
      Basophilic Focus                     |                         X                             X  X               |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                            2        2        2                           |             
      Bile Duct, Hyperplasia               | 2  1  3  2  4  3  3  2  2     3  3  1  2  3  3  2  2  3  3  2  4  2  1  4|             
      Hepatocyte, Atrophy, Multifocal      |          2        2                                            2        3|             
      Hepatocyte, Hyperplasia, Nodular     |                                                                3         |             
      Hepatocyte, Necrosis, Multifocal     |                                                 2  2                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                3     2        2                                      1   |             
      Hepatocyte, Centrilobular, Necrosis  |                                                             2            |             
      Portal, Fibrosis                     |       2  2     2  2     2     2  2  1        2           2        1     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                                               +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                                             3            |             
      Fat, Necrosis, Focal                 |          3                                                     4         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3        4     1        4        2     2                    2     1  3|             
      Cyst                                 |                   X                                                      |             
      Hyperplasia                          |    2                       2  3                          3     2         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                     +                                    |             
      Palate, Hyperplasia                  |                                     3                                    |             
      Palate, Inflammation, Suppurative    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                    3                     |             
      Forestomach, Mineralization          |                                                          4               |             
      Forestomach, Ulcer                   |                                                                          |             
      Forestomach, Mucosa, Hyperplasia     |                      3  2           2              3                    3|             
      Glandular, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Glandular, Erosion                   |       2                                         3                        |             
      Glandular, Mineralization            |                         2                 2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                       +  +               |             
      Hypertrophy                          |                                                          3               |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                      X   |             
      Artery, Mineralization               |                                                                          |             
      Myocardium, Fibrosis                 | 3  3  2     2  3     2     2  2        3  2     2  2     2     3     2  2|             
      Myocardium, Inflammation, Chronic    |    3                 2  2        1     1                                 |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Myocardium, Metaplasia, Osseous      |                            2                                             |             
      Myocardium, Mineralization           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Fibrosis                     |                                                                   3      |             
      Cortex, Hematocyst                   |                                  X                                   X   |             
      Cortex, Hyperplasia                  |          2                                                               |             
      Cortex, Inflammation, Suppurative    |                                                                          |             
      Cortex, Vacuolization Cytoplasmic    |                                                                          |             
      Extra Adrenal Tissue, Developmental  |                                                                          |             
          Malformation                     |                                                                         X|             
      Medulla, Hyperplasia                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X                    X        X                                   X   |             
      Pars Distalis, Hyperplasia           |                            2                 3                    1      |             
      Pars Intermedia, Cyst                |             X                                                  X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                      2  2|             
      Follicle, Dilatation                 |                                  2                                       |             
      Follicle, Pigmentation               |          2                       2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Hyperplasia                          |       3     2                                4                    4      |             
      Inflammation, Chronic                | 3              2  2  3           3        3           3  3  3            |             
      Inflammation, Suppurative            |       4                    4        2  2  3  3     2           3  4      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |             3           2                                      2         |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            | 3        3  2                                   2     2        2        2|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |          3                 3                                3            |             
      Seminiferous Tubule, Mineralization  |       2  2  2           2  3  2           3              2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |             2                                                            |             
      Hyperplasia, Reticulum Cell          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hemorrhage                 |                                                                          |             
      Inguinal, Lymphatic, Ectasia         |                                                                          |             
      Lymphatic, Mandibular, Ectasia       |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |       2              3     2        3                                    |             
      Mandibular, Metaplasia, Osseous      |       4                                                                  |             
      Mediastinal, Atrophy                 |                                                                          |             
      Mediastinal, Erythrophagocytosis     |                      3        3                                          |             
      Mediastinal, Hemorrhage              |          2           2     2                                      3      |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Pigmentation            |          2                                                  3            |             
      Mediastinal, Lymphatic, Ectasia      |                                                                          |             
      Mesenteric, Atrophy                  | 3  3                                                                     |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hyperplasia, Histiocytic |                                        2                                 |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                                2         |             
      Mesenteric, Necrosis                 |                                        2                                 |             
      Mesenteric, Lymphatic, Ectasia       |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Pigmentation             |                                                                         3|             
      Pancreatic, Lymphatic, Ectasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3        3                 2         |             
      Congestion                           | 2                                                                        |             
      Degeneration, Fatty                  |                   4                                                      |             
      Fibrosis                             |                                              3                 2        3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             3              2                 2                           |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphatic, Ectasia                   |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  M  M|             
      Cyst                                 |          X                 X                 X                           |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Cystic                  | 3  2     2  1     2                                3           2         |             
      Hyperplasia, Lobular                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                      X              X                                    |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                    2                     |             
      Hyperostosis                         |                                     3                          X         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Degeneration, Multiple               |                      4                                                   |             
      Cerebrum, Degeneration               |                                                                          |             
      Thalamus, Hemorrhage                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Infiltration Cellular, Lymphocyte,   |                                                                          |             
           Polymorphonuclear               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         | 2           3     4           3                                          |             
      Edema, Diffuse                       |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  1  1  1        1  1     1  1     1  1  1        1  1  1     1      |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Granulomatous          |    3                                            3              3         |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Mineralization               |             2                 2                                          |             
      Parenchyma, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        |                      3                                         3         |             
      Lumen, Inflammation, Suppurative     |                      3                                         3         |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                3         |             
      Mucosa, Necrosis                     |                            2                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         3|             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Hyperplasia                          |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |             2              2                                             |             
      Inflammation, Chronic                | 1  3  3  3              3  3     3  3  3  2        3  3  2        2  3  4|             
      Inflammation, Suppurative            |                                        1              1                  |             
      Nephropathy                          | 2  3  3  3  1  2  2  3  3  3  2  3  3  3  2  2  2  4  3  2  1  2  2  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Mineralization               |                               1                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |          1                                1                              |             
      Renal Tubule, Pigmentation           |                                                             3            |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Parasite Metazoan             |                                                 2        2               |      4  1.5|
      Colon, Mineralization                |                   4                                                      |      1  4.0|
      Colon, Parasite Metazoan             | 2                                2                    2                 4|      9  2.1|
      Rectum, Parasite Metazoan            |             2                                   2                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Jejunum, Inflammation, Chronic       |    3                                                           3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      4  2.3|
      Basophilic Focus                     |       X  X  X     X  X  X  X        X           X  X  X              X  X|     16     |
      Clear Cell Focus                     |                            X           X              X                 X|      4     |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Hematopoietic Cell Proliferation     | 2                                                              2         |      2  2.0|
      Inflammation, Chronic                |                                     2     3     2  2                    2|      8  2.1|
      Bile Duct, Hyperplasia               |    2  2  3  3  3  2  2  2  3     4  2  3  2  3  2  2  2  2  2  2  2  3  3|     47  2.5|
      Hepatocyte, Atrophy, Multifocal      |                                  3     2                                 |      6  2.3|
      Hepatocyte, Hyperplasia, Nodular     |                                                                          |      1  3.0|
      Hepatocyte, Necrosis, Multifocal     |                      2                                                   |      3  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                3                             3  2                        |      7  2.3|
      Hepatocyte, Centrilobular, Necrosis  | 2                                                              3         |      3  2.3|
      Portal, Fibrosis                     |          2  2        2  2        3  2  3  2     1     2  1        2      |     24  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +        +           +                              |   9        |
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |          2                                                               |      3  3.0|
      Fat, Necrosis                        |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1                 3                    1     3  4     3     2  2|     17  2.4|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |       1                             3           3              2         |      9  2.3|
      Infiltration Cellular, Lymphocyte    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Hyperplasia                  |                                                                          |      1  3.0|
      Palate, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Inflammation, Chronic   |                                                 2                        |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Forestomach, Mineralization          |                   4                                                      |      2  4.0|
      Forestomach, Ulcer                   |    4                                                        3            |      2  3.5|
      Forestomach, Mucosa, Hyperplasia     |    3        2           2                       2                        |      9  2.4|
      Glandular, Cyst                      |                                                    X                     |      1     |
      Glandular, Erosion                   |    4                                                        2            |      4  2.8|
      Glandular, Mineralization            |       2     2     4  2                             3  3  2           3   |     10  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   2        |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +           +                                                      |   4        |
      Hypertrophy                          |       3                                                                  |      2  3.0|
      Inflammation, Chronic Active         |       3                                                                  |      2  2.5|
      Mineralization                       |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           | X                                                                        |      2     |
      Artery, Mineralization               |                   2                                                      |      1  2.0|
      Myocardium, Fibrosis                 | 3  2  1     2  3  3     2  3     3  3  2  2  2  2  2     2  2     3  2  3|     36  2.3|
      Myocardium, Inflammation, Chronic    |                      2                    2           2        1         |      9  1.8|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           | 3                                                                        |      1  3.0|
      Myocardium, Metaplasia, Osseous      |                                                                          |      1  2.0|
      Myocardium, Mineralization           |                   2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2                                                                        |      1  2.0|
      Cortex, Cyst                         |                                                                X  X      |      2     |
      Cortex, Fibrosis                     |                                                                          |      1  3.0|
      Cortex, Hematocyst                   |                   X                                                      |      3     |
      Cortex, Hyperplasia                  |                                                    2        3            |      3  2.3|
      Cortex, Inflammation, Suppurative    |                                                             1            |      1  1.0|
      Cortex, Vacuolization Cytoplasmic    |    2                 2                                               2   |      3  2.0|
      Extra Adrenal Tissue, Developmental  |                                                                          |            |
          Malformation                     |                   X                                X                     |      3     |
      Medulla, Hyperplasia                 | 2                                               3                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                 3                        |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |    1                                                                    1|      5  1.6|
      Pars Intermedia, Cyst                |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          2  2                                   2                 2     2|      7  2.0|
      Follicle, Dilatation                 |                                                                          |      1  2.0|
      Follicle, Pigmentation               |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    4     2           3        3  3                                       |      9  3.1|
      Inflammation, Chronic                |          3  2                          3     3        2     3     2      |     16  2.7|
      Inflammation, Suppurative            | 4  4     3           4        4        2                                2|     16  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |          2                 2                                            3|      6  2.3|
      Fibrosis                             |    3                 4                                                   |      2  3.5|
      Inflammation, Chronic                |                      4                                                   |      1  4.0|
      Inflammation, Suppurative            | 2        2           4        3     2  2     2                 3     2  2|     17  2.4|
      Epithelium, Hyperplasia              |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                          +           +  +|   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       | 2                                                                    2   |      2  2.0|
      Seminiferous Tubule, Atrophy         |    3              4  2                                                   |      6  3.0|
      Seminiferous Tubule, Mineralization  |             2           3        2  2     3     3     2        2        3|     17  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia                          |                      3                                                   |      2  2.5|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hemorrhage                 |                                                 3                        |      1  3.0|
      Inguinal, Lymphatic, Ectasia         |                                                 3                        |      1  3.0|
      Lymphatic, Mandibular, Ectasia       |       2                          3                          3           2|      4  2.5|
      Mandibular, Hyperplasia, Plasma Cell |       2              3                 3                          3      |      8  2.6|
      Mandibular, Metaplasia, Osseous      |                                                                          |      1  4.0|
      Mediastinal, Atrophy                 | 3                                                                        |      1  3.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      2  3.0|
      Mediastinal, Hemorrhage              |                                           3                    2         |      6  2.3|
      Mediastinal, Hyperplasia, Plasma Cell|                      3                                                   |      1  3.0|
      Mediastinal, Pigmentation            |       3                                                                  |      3  2.7|
      Mediastinal, Lymphatic, Ectasia      |       2                                                                  |      1  2.0|
      Mesenteric, Atrophy                  |                      3                                                   |      3  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                2         |      1  2.0|
      Mesenteric, Hyperplasia, Histiocytic |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mesenteric, Necrosis                 |                                                                          |      1  2.0|
      Mesenteric, Lymphatic, Ectasia       |       2                                                        2         |      2  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |       2                                                                  |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Pancreatic, Lymphatic, Ectasia       |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                            3                                             |      4  2.8|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      1  4.0|
      Fibrosis                             |                            3                                             |      4  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                3         |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     | 4     2  2           2                                         3  2      |      9  2.4|
      Hyperplasia, Histiocytic             |                3                                                         |      1  3.0|
      Pigmentation, Hemosiderin            |                   4                       3                              |      2  3.5|
      Lymphatic, Ectasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  +  +  +  +  +  +  M  +  +  +  M  M  M  M  +  +  M  +  +  +|  34        |
      Cyst                                 |                            X              X                              |      5     |
      Ectopic Parathyroid Gland            |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Hyperplasia, Cystic                  | 2        1     1  4  3        3                             3     3  3   |     16  2.4|
      Hyperplasia, Lobular                 |                   4                                                      |      1  4.0|
      Inflammation, Suppurative            |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Foreign Body                         |                                        3                                 |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                        3                                 |      1  3.0|
      Inflammation, Suppurative            |                            2                                      3      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                   2                                                      |      2  2.0|
      Hyperostosis                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                   3  3   |      2  3.0|
      Degeneration, Multiple               |                                           3                    2         |      3  3.0|
      Cerebrum, Degeneration               |                                  2                                       |      1  2.0|
      Thalamus, Hemorrhage                 |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mast Cell     |                                                                         2|      1  2.0|
      Infiltration Cellular, Lymphocyte,   |                                                                          |            |
           Polymorphonuclear               |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                                                   2      |      5  2.8|
      Edema, Diffuse                       |                                              3                           |      1  3.0|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Infiltration Cellular, Histiocyte    |    2  1  1  1           3  2              2  1  1  2  1  2               |     28  1.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                      3                                                   |      4  3.0|
      Inflammation, Suppurative            |                   2                          3                           |      2  2.5|
      Artery, Mineralization               |                                                                          |      2  2.0|
      Parenchyma, Mineralization           |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3|            |
                                           | 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Foreign Body                  |       2                                               3                  |      2  2.5|
      Lumen, Fungus                        |                      4                                      3            |      4  3.3|
      Lumen, Inflammation, Suppurative     | 2  2  2              4                                2     3            |      8  2.6|
      Mucosa, Hyperplasia                  |                                                       2                  |      1  2.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      1  3.0|
      Mucosa, Necrosis                     |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                           2                              |      2  2.5|
      Submucosa, Inflammation, Chronic     |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   2        |
      Cataract                             |                                                                   2      |      1  2.0|
      Retina, Atrophy                      |                                                                   4      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                   4                                                      |      3  2.7|
      Inflammation, Chronic                |    3  3  2  3        3  3           3           3  2  2  2     2  3  2   |     30  2.7|
      Inflammation, Suppurative            |       1  1                          2                             2      |      6  1.3|
      Nephropathy                          | 2  4  3  2  3  1  3  3  3  2  2  2  3  2  2  2  3  2  3  2  2  2  3  3  2|     50  2.5|
      Papilla, Necrosis                    |                   3                                                      |      1  3.0|
      Pelvis, Mineralization               |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |                   3                                                      |      1  3.0|
      Renal Tubule, Mineralization         |    2     1        4  1                 1  2                              |      8  1.6|
      Renal Tubule, Pigmentation           |                                           2                       2      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                   +                                                      |   1        |
      Dilatation                           |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|             
                                           | 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Fibrosis                      | 3                                                                        |             
      Cecum, Mineralization                |                                                                          |             
      Cecum, Parasite Metazoan             |                                                                          |             
      Colon, Edema                         |                                                                          |             
      Colon, Inflammation, Chronic Active  |                                                                          |             
      Rectum, Parasite Metazoan            |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Erosion                    |                                                                          |             
      Duodenum, Inflammation, Chronic      |                                                                          |             
      Duodenum, Inflammation, Suppurative  |                                                             2            |             
      Muscularis, Jejunum, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
      Basophilic Focus                     |          X              X  X     X                       X              X|             
      Clear Cell Focus                     |                      X     X                                            X|             
      Cyst Multilocular                    |       X     X                    X                 X                 X   |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hemorrhage                           |                      3                             3                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                 1                        |             
      Inflammation, Granulomatous          |                                                                   2      |             
      Mixed Cell Focus                     |                                                    X                     |             
      Bile Duct, Hyperplasia               | 1  3     3        2  2  2     2  2  2     2  2  2  2  3  2  3  3  1  3  2|             
      Hepatocyte, Atrophy, Multifocal      |       2                                               2        3     3   |             
      Hepatocyte, Hyperplasia, Nodular     |       2                                                                  |             
      Hepatocyte, Necrosis, Multifocal     |                                                             1            |             
      Hepatocyte, Vacuolization Cytoplasmic|                3  3        2        3     2  3  3        2     3  2      |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
      Portal, Fibrosis                     |          2  3     2     2  1                       3     2     2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +        +     +                                          |             
      Mineralization                       |                                                                          |             
      Fat, Inflammation, Granulomatous     |    4                                                                     |             
      Fat, Necrosis, Focal                 |    4           4        2     4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     1                          2     4              3     2  4     1  2|             
      Hyperplasia                          |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                          |             
      Forestomach, Erosion                 |                                        3                                 |             
      Forestomach, Fibrosis                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|             
                                           | 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           | 3                                                                        |             
      Forestomach, Mineralization          |                                                                          |             
      Forestomach, Perforation             |                                                                          |             
      Forestomach, Ulcer                   | 4                                                     2                  |             
      Forestomach, Mucosa, Hyperplasia     |                                        3                                 |             
      Glandular, Erosion                   |                                                                          |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Mineralization            |    2                                                                 2   |             
      Glandular, Ulcer                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                          +            |             
      Inflammation, Chronic Active         |                                  3                          3            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                      X                                                   |             
      Myocardium, Fibrosis                 | 2  3     2  2  3  3  3  3  2        3  2     2  2  3  3  3     2  2     3|             
      Myocardium, Inflammation, Chronic    |                      3                                                   |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Hyperplasia                  |                                                                          |             
      Cortex, Vacuolization Cytoplasmic    | 2  2           1        2                       2     2                 2|             
      Extra Adrenal Tissue, Developmental  |                                                                          |             
          Malformation                     |                   X     X                                                |             
      Medulla, Hyperplasia                 |          2           2                                               2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                             4            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Necrosis              |                                                             3            |             
      Pars Intermedia, Cyst                |                                                                X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|             
                                           | 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Ultimobranchial Cyst                 |                               X              X                           |             
      C-Cell, Hyperplasia                  |          1  2           1  1  2                    1                 1  3|             
      Follicle, Dilatation                 | 3                       3                                                |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
      Ectasia                              |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                       2                  |             
      Hyperplasia                          |    3                 4  2              4           2                     |             
      Inflammation, Chronic                |             3           3        2                 3  2     2            |             
      Inflammation, Suppurative            | 3  3                 4  3              3                             4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |    2                                      2                              |             
      Inflammation, Suppurative            |    2                    2           2              1  1     3     2     3|             
      Epithelium, Hyperplasia              |                         2                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             4            |             
      Hemorrhage                           |                                                             4            |             
      Necrosis                             |                                                             4            |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                          4               |             
      Seminiferous Tubule, Mineralization  |    2                 3              2  1           2  2        2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      4                                                   |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Plasma Cell   |                      3                                                   |             
      Bronchial, Pigmentation              |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                      4                                                   |             
      Inguinal, Lymphatic, Ectasia         |                      3                                                   |             
      Lumbar, Lymphatic, Ectasia           |                      4                                                   |             
      Lymphatic, Mandibular, Ectasia       |    3     2           4                                                   |             
      Mandibular, Hyperplasia, Plasma Cell |    3     2           3                                                   |             
      Mediastinal, Atrophy                 | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|             
                                           | 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Erythrophagocytosis     | 3                                                                        |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |       3                                                                  |             
      Mediastinal, Lymphatic, Ectasia      |                      3                                                   |             
      Mesenteric, Atrophy                  |             3                                3                 3         |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                   3      |             
      Mesenteric, Lymphatic, Ectasia       |                                                                         3|             
      Renal, Pigmentation                  |                         3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |             2        3                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             2        2        3                                          |             
      Pigmentation, Hemosiderin            |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  M  +  +  M  M  M  M  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3                             3                 2        2           2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Exudate                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Multiple               |                                                    3                     |             
      Necrosis                             |                                                                          |             
      Cerebellum, Mineralization           |                                                                          |             
      Cerebrum, Degeneration               |                                                                          |             
      Cerebrum, Hemorrhage                 |                                                 3                        |             
      Cerebrum, Necrosis                   |                                                 3                        |             
      Thalamus, Degeneration               |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|             
                                           | 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8.0                                    | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Edema, Diffuse                       |                                                                          |             
      Foreign Body                         |                                                 2  3                     |             
      Hemorrhage                           |    3                                                                     |             
      Infiltration Cellular, Histiocyte    | 1           2           1  1  1     1           3     2  2  2     2  1   |             
      Inflammation, Granulomatous          |                                  2                 3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |          3                                                               |             
      Lumen, Inflammation, Suppurative     |    1     3                                         1        2            |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                         2                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Submucosa, Inflammation, Chronic     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +           +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Angiectasis                          |                                                          3               |             
      Cataract                             | 3  3  2  3  3           3  3  3  3  3  3  3     3  3  3  3     3     3  3|             
      Retinal Detachment                   |                                                                          |             
      Synechia                             |                                                 3                        |             
      Retina, Atrophy                      | 3  3  3  3  3           3  3  3  3  3  3  4     3  4  3  3     3     4  4|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                | 3  3     3           2  3  3  2  3  2  3  2        2                 2  3|             
      Inflammation, Suppurative            | 1        1              1                          1                     |             
      Nephropathy                          | 3  3  2  3  2  1     2  3  3  2  3  2  3  2  2  1  2  2  1  2  3  2  2  3|             
      Renal Tubule, Mineralization         |                                                                1         |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  M  M  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cecum, Fibrosis                      |                                                                          |      1  3.0|
      Cecum, Mineralization                |                                        3                                 |      1  3.0|
      Cecum, Parasite Metazoan             |                                        2                                 |      1  2.0|
      Colon, Edema                         |                               2                                          |      1  2.0|
      Colon, Inflammation, Chronic Active  |                               3                                          |      1  3.0|
      Rectum, Parasite Metazoan            |       2                    2              1                              |      4  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duodenum, Erosion                    |                                  3                                       |      1  3.0|
      Duodenum, Inflammation, Chronic      |                                  2                                       |      1  2.0|
      Duodenum, Inflammation, Suppurative  |                                                                          |      1  2.0|
      Muscularis, Jejunum, Hyperplasia     |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                3                                                         |      2  3.0|
      Basophilic Focus                     |          X                          X  X                 X               |     10     |
      Clear Cell Focus                     |          X  X                       X                                    |      6     |
      Cyst Multilocular                    |                                                                          |      5     |
      Hematopoietic Cell Proliferation     |                                              2                           |      2  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Chronic                |                         2              2                       2  2      |      4  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |          2                                                               |      2  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2  2  3  2  2     1  2  2  2  2     1  2  2  1  4  3  3  3  2  2  1  2  2|     43  2.1|
      Hepatocyte, Atrophy, Multifocal      |                3                                3  2  2                 2|      9  2.4|
      Hepatocyte, Hyperplasia, Nodular     |                3           3                                             |      3  2.7|
      Hepatocyte, Necrosis, Multifocal     |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                         2  2  2  4  3     2  1     3        3            |     19  2.5|
      Hepatocyte, Centrilobular, Necrosis  |                   2                                                      |      1  2.0|
      Portal, Fibrosis                     |       1                             1     1     3     2  3              1|     15  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +           +  +        +   |   8        |
      Mineralization                       |                                                                      2   |      1  2.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                              3           3               |      6  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2        2     4  2     2     2                    2        2           3|     18  2.3|
      Hyperplasia                          | 3                       2                    2  2              2  3  2   |      9  2.4|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   |                2                                                         |      1  2.0|
      Forestomach, Erosion                 |                               2                                          |      2  2.5|
      Forestomach, Fibrosis                |                                                                          |      1  3.0|
      Forestomach, Inflammation, Chronic   |                                                                2        2|      2  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Forestomach, Mineralization          |                         2                                                |      1  2.0|
      Forestomach, Perforation             |                                  X                                       |      1     |
      Forestomach, Ulcer                   |                                                                          |      2  3.0|
      Forestomach, Mucosa, Hyperplasia     |          2     2                 3                             3        3|      6  2.7|
      Glandular, Erosion                   |                                  3                                       |      1  3.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                   2                                                      |      1  2.0|
      Glandular, Mineralization            |                         2           3                                    |      4  2.3|
      Glandular, Ulcer                     |                   4                                3                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +           +                                                   |   2        |
      Epithelium, Hyperplasia              |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +                                                                  |   3        |
      Inflammation, Chronic Active         |       3                                                                  |      3  3.0|
      Mineralization                       |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thrombosis                           |                   X                          X                           |      3     |
      Myocardium, Fibrosis                 | 2     2  3  3  2        2     3  2  3     3     2  2  2     2  2  2  3   |     36  2.4|
      Myocardium, Inflammation, Chronic    |                                        1                          2      |      3  2.0|
      Myocardium, Mineralization           |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Hyperplasia                  |                   2                                                      |      1  2.0|
      Cortex, Vacuolization Cytoplasmic    |          2                       2                    1     2  3  3      |     13  2.0|
      Extra Adrenal Tissue, Developmental  |                                                                          |            |
          Malformation                     |                                                                          |      2     |
      Medulla, Hyperplasia                 |                      3                                                   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                     2                                    |      1  2.0|
      Pars Distalis, Cyst                  |                                        X                 X               |      2     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |    2                                   3                             1   |      3  2.0|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                          X               |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |          2                                                     1  1      |     11  1.5|
      Follicle, Dilatation                 |          2              3                                                |      4  2.8|
      Follicular Cell, Hyperplasia         |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Ectasia                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      5  3.0|
      Inflammation, Chronic                |       2     2        2  3                                2  3            |     12  2.4|
      Inflammation, Suppurative            | 2                 3                                      2           4   |     10  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Corpora Amylacea                     |       3                                                     3     3      |      3  3.0|
      Edema                                |                               4                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |          2              2  2  4  3  2                    2     3  2      |     17  2.2|
      Epithelium, Hyperplasia              |                            3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                         +                          +                     |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                2         |      1  2.0|
      Seminiferous Tubule, Atrophy         |                   3                 3                                    |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Mineralization  |             3        2                    2        3  1           2  2   |     14  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        2                                 |      2  3.0|
      Hyperplasia, Reticulum Cell          |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |      1  3.0|
      Bronchial, Pigmentation              |                                                             3            |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  4.0|
      Inguinal, Lymphatic, Ectasia         |                                                                          |      1  3.0|
      Lumbar, Lymphatic, Ectasia           |                                                                          |      1  4.0|
      Lymphatic, Mandibular, Ectasia       |                            2                          3              2  3|      7  2.7|
      Mandibular, Hyperplasia, Plasma Cell |          3                                      3     3                  |      6  2.8|
      Mediastinal, Atrophy                 |                                                                          |      1  4.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                               3              2                       2   |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |       3                                                                  |      1  3.0|
      Mediastinal, Pigmentation            |                                                             3        3   |      3  3.0|
      Mediastinal, Lymphatic, Ectasia      |                                                                          |      1  3.0|
      Mesenteric, Atrophy                  |          4                                                  3            |      5  3.2|
      Mesenteric, Hemorrhage               | 2                                                                        |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mesenteric, Lymphatic, Ectasia       |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                   3                                                      |      3  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |    2                                   2     3           2  2            |      8  2.3|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  M  M  M  M  M  M  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  34        |
      Cyst                                 |                                           X                              |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|  46        |
      Hyperplasia, Cystic                  |          3                    2  4           2  3              4         |     12  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           | 2                                         3                          4   |      3  3.0|
      Cyst Epithelial Inclusion            |    X                                                                     |      1     |
      Exudate                              | 2                                         3                          4   |      3  3.0|
      Hyperkeratosis                       |                                                                      4   |      1  4.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                 3              2         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Multiple               |                      2              3              2                     |      4  2.5|
      Necrosis                             |          2                                                               |      1  2.0|
      Cerebellum, Mineralization           |                                                    3                     |      1  3.0|
      Cerebrum, Degeneration               | 2                                                                        |      1  2.0|
      Cerebrum, Hemorrhage                 |                                                                          |      1  3.0|
      Cerebrum, Necrosis                   |                                                                          |      1  3.0|
      Thalamus, Degeneration               |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenomatosis                         | 2                                            2                          2|      3  2.0|
      Edema, Diffuse                       |                               3                                          |      1  3.0|
      Foreign Body                         |                                                                          |      2  2.5|
      Hemorrhage                           |                                              2                           |      2  2.5|
      Infiltration Cellular, Histiocyte    | 2     1  2        1  1  1        2  1  2  2  2     2  1     2     1  2  1|     29  1.6|
      Inflammation, Granulomatous          |                            1                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumen, Fungus                        |                                                                          |      1  3.0|
      Lumen, Inflammation, Suppurative     |             2              3     2                                       |      7  2.0|
      Mucosa, Hyperplasia                  |                            2                                             |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                            3                                             |      1  3.0|
      Submucosa, Inflammation, Chronic     |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    8.0                                    | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Exudate                       | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
      Middle Ear, Inflammation, Suppurative|                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +        +                       +        +           +  +  +  +  +|  28        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cataract                             |       1                                2                       3  3  2  2|     25  2.8|
      Retinal Detachment                   |                                                                   X      |      1     |
      Synechia                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |       3        3                       4        2           3  3  4  3  3|     28  3.2|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                    2                     |      1  2.0|
      Inflammation, Chronic                |       2  3     3     2     3  2  2     2                 2     3  4  2  2|     27  2.5|
      Inflammation, Suppurative            |                                        2              1           1  1   |      8  1.1|
      Nephropathy                          | 2  3  2  3  2  3  2  2  2  3  3  3  2  2  2  1  2  2  1  2  2  4  3  3  2|     49  2.3|
      Renal Tubule, Mineralization         |       1  2                          1                 1              1   |      6  1.2|
      Renal Tubule, Pigmentation           | 2                                                           3            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Erosion                       |                                                                          |             
      Colon, Parasite Metazoan             |    2                             2                       2           2   |             
      Rectum, Parasite Metazoan            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Mucosa, Hyperplasia        |                                                                          |             
      Ileum, Mineralization                |                                                                          |             
      Ileum, Ulcer                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                X        X  X                    X     X                  |             
      Clear Cell Focus                     | X                       X  X                          X                  |             
      Cyst Multilocular                    |                                  X                                   X   |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  2  4  2  2  4  2  1        2  3  2  2  2  3  2  2  3           3  2|             
      Hepatocyte, Atrophy, Multifocal      |    3              2  2                                   2           2   |             
      Hepatocyte, Hyperplasia, Nodular     |          3        2                 2                    2               |             
      Hepatocyte, Necrosis, Multifocal     |          2                                                               |             
      Hepatocyte, Vacuolization Cytoplasmic| 2              2           3  4  3           2              4            |             
      Portal, Fibrosis                     |    3     2                 1        2     2     2                    2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +  +  +     +                                                |             
      Ectopic Tissue                       |                                                                          |             
      Fat, Fibrosis                        |                                                                          |             
      Fat, Inflammation, Granulomatous     |                   3                                                      |             
      Fat, Inflammation, Suppurative       |                         2                                                |             
      Fat, Necrosis, Focal                 |             3           3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              | 1           2           2                 1              1     2        1|             
      Hyperplasia                          |                                           2        2     3     2         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
      Palate, Ulcer                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Diverticulum            |             X                                                            |             
      Forestomach, Edema                   |                               3                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Forestomach, Inflammation,           |                                                                          |             
          Suppurative                      |                                     2                                    |             
      Forestomach, Mineralization          |                                                                          |             
      Forestomach, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Perforation             |       X                                                                  |             
      Forestomach, Ulcer                   |                               4                                          |             
      Forestomach, Mucosa, Dysplasia       |                                                                          |             
      Forestomach, Mucosa, Hyperplasia     |       4        2              3     1                             2      |             
      Glandular, Erosion                   |       3  3                                                               |             
      Glandular, Hemorrhage                |                                                                          |             
      Glandular, Mineralization            |                3                          1           2  3              2|             
      Glandular, Necrosis                  |                                                                          |             
      Glandular, Ulcer                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +              +                                 |             
      Hypertrophy                          |                         3                                                |             
      Inflammation, Chronic Active         |                         3              2                                 |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 | 2  3     2  2  2  3  2  2  2     2  2  2     3  3  3  3  3  2        2  2|             
      Myocardium, Inflammation, Chronic    |                            1              1        2                     |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |    2                                                                     |             
      Myocardium, Metaplasia, Osseous      |                                                                          |             
      Myocardium, Mineralization           |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                4                                                         |             
      Pigmentation                         |                4                                                         |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Hematocyst                   |                                                                      X   |             
      Cortex, Hyperplasia                  |             2                                                            |             
      Cortex, Necrosis                     |                      4                                                   |             
      Cortex, Vacuolization Cytoplasmic    |       2     2  3           2                                            2|             
      Extra Adrenal Tissue, Developmental  |                                                                          |             
          Malformation                     |                                                                          |             
      Medulla, Hyperplasia                 |                                        2           2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Angiectasis           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                   3  2                 2                                 |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2                 3                                                |             
      Follicle, Pigmentation               |                                              2                          2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +|             
      Ectasia                              |                               4     3                 3                  |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic                | 2     3  2           2                       2        2              3   |             
      Inflammation, Suppurative            |                            4  2     2                                2  4|             
      Metaplasia, Squamous                 |                            4                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |          3     4  1     2     3  2        1  1  3           2            |             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +                                      +                  |             
      Fibrosis                             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                   3                                3                    4|             
      Seminiferous Tubule, Mineralization  |    3     3     2     2  2  2        2  2              2              3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                         2|             
      Hyperplasia, Reticulum Cell          |                            1                                             |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphatic, Mandibular, Ectasia       |                                                 3                    3   |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |          2  2                                                            |             
      Mediastinal, Erythrophagocytosis     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hemorrhage              | 3                                            3                           |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                              3                           |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                              3                           |             
      Mediastinal, Pigmentation            |                         3                                                |             
      Mediastinal, Lymphatic, Ectasia      |                                                                          |             
      Mesenteric, Atrophy                  |             3                                                            |             
      Mesenteric, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |    3              3                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                2        3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             2  3           2  2              2                          2|             
      Necrosis                             |    4                                                                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphatic, Ectasia                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  M  +  I  M  +  +  +  M  +  +  M  +  +  +  M  +  +|             
      Cyst                                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  M|             
      Angiectasis                          |                         4                                                |             
      Hyperplasia, Cystic                  |       2  3     2              2              1  1                        |             
      Hyperplasia, Lobular                 |                                                                          |             
      Inflammation, Granulomatous          |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Acanthosis                           |                                                    3                     |             
      Cyst Epithelial Inclusion            |                               X                                          |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    3                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2                                                               |             
      Degeneration, Multiple               |                                        1                 3               |             
      Cerebrum, Degeneration               |    1                                                                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                              2                           |             
      Edema, Diffuse                       |                                                                          |             
      Foreign Body                         | 4                                3                          2     3      |             
      Hemorrhage                           |                                  3                                       |             
      Infiltration Cellular, Histiocyte    |       1     2        2     1        3  1  1  1  1     1        1  1  1  2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          | 2                                                                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation                         |                   3                                                      |             
      Artery, Media, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Fungus                        |                            3                                             |             
      Lumen, Hemorrhage                    |                                                                   2      |             
      Lumen, Inflammation, Suppurative     |                            2                                             |             
      Mucosa, Metaplasia, Squamous         |                                     3                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2                                          |             
      Nasopharyngeal Duct, Foreign Body    |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Submucosa, Inflammation, Chronic     |                            3        2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +              M         |             
      Cataract                             |                                                 3                        |             
      Retina, Atrophy                      |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Inflammation, Chronic                |       3     3     3  2  2  2           3  2     2  2  2                 2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|             
                             DAY ON TEST   | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|             
                                           | 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4.0                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |    2              1                                                      |             
      Nephropathy                          | 1  2  3  1  4  2  3  3  2  2  3  1  1  3  2  2  2  2  2  1  1  1     3  2|             
      Pelvis, Mineralization               |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Renal Tubule, Mineralization         |          1              2                                1              1|             
      Renal Tubule, Pigmentation           |                               2     3                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cecum, Erosion                       |    3                                                                     |      1  3.0|
      Colon, Parasite Metazoan             |                         2                          1                     |      6  1.8|
      Rectum, Parasite Metazoan            |             2        2                                                  2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duodenum, Mucosa, Hyperplasia        |                                                             4            |      1  4.0|
      Ileum, Mineralization                |                      3                                                   |      1  3.0|
      Ileum, Ulcer                         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     3                                3  3|      3  3.0|
      Basophilic Focus                     |          X              X  X                          X        X     X  X|     12     |
      Clear Cell Focus                     |                      X                                X                 X|      7     |
      Cyst Multilocular                    |                                           X           X  X  X            |      6     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |             2           2                          2        2        1   |      6  1.8|
      Inflammation, Granulomatous          |                                                    2                     |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2     2  1  3  3  2  2  2        4  2  4  2  4     2        2  2  2  3|     39  2.4|
      Hepatocyte, Atrophy, Multifocal      |                3                    2     2                              |      8  2.3|
      Hepatocyte, Hyperplasia, Nodular     |                3                    2                                    |      6  2.3|
      Hepatocyte, Necrosis, Multifocal     |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic| 3              3        3  2  3                             2            |     13  2.8|
      Portal, Fibrosis                     |       2        2     1           1              3           3     1      |     14  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +  +         |   7        |
      Ectopic Tissue                       |                                                             X            |      1     |
      Fat, Fibrosis                        |                                                             3            |      1  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Inflammation, Suppurative       |                                                             3            |      2  2.5|
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                         3                 4           1  2  3  2  2      |     14  1.9|
      Hyperplasia                          |       2     3     2                                      3              2|      9  2.3|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                +         |   2        |
      Palate, Ulcer                        |                                                                3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Diverticulum            |                                                                          |      1     |
      Forestomach, Edema                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Inflammation, Chronic   |                                        2                                 |      1  2.0|
      Forestomach, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Forestomach, Mineralization          |                                           3              2               |      2  2.5|
      Forestomach, Necrosis                |                                  4                                       |      1  4.0|
      Forestomach, Perforation             |                                  X                                       |      2     |
      Forestomach, Ulcer                   |    3                                                        4            |      3  3.7|
      Forestomach, Mucosa, Dysplasia       |                                                                   1      |      1  1.0|
      Forestomach, Mucosa, Hyperplasia     |                                  3                          4     2      |      8  2.6|
      Glandular, Erosion                   |                                     2                                    |      3  2.7|
      Glandular, Hemorrhage                |    3                                                                     |      1  3.0|
      Glandular, Mineralization            |                         3  2           2                          1      |      9  2.1|
      Glandular, Necrosis                  |    3                                                                     |      1  3.0|
      Glandular, Ulcer                     |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                           +                              |   1        |
      Epithelium, Hyperplasia              |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                   +      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +     +                                                            |   4        |
      Hypertrophy                          |       3                                                                  |      2  3.0|
      Inflammation, Chronic Active         |       3                                                                  |      3  2.7|
      Mineralization                       |             2                                                            |      1  2.0|
      Thrombosis                           |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Fibrosis                 | 2     3  2     2     2  2  3  2  2  2     3  3  2  2     3  2     3     3|     38  2.4|
      Myocardium, Inflammation, Chronic    |    2     2  2           1                                      1        2|      9  1.6|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                   2                                                      |      2  2.0|
      Myocardium, Metaplasia, Osseous      |                                     2                                    |      1  2.0|
      Myocardium, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  4.0|
      Cortex, Cyst                         |                                                 X                        |      1     |
      Cortex, Hematocyst                   |                                                                          |      1     |
      Cortex, Hyperplasia                  |                                                    2        3            |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Necrosis                     |                                                                          |      1  4.0|
      Cortex, Vacuolization Cytoplasmic    |                2                          2        2                     |      8  2.1|
      Extra Adrenal Tissue, Developmental  |                                                                          |            |
          Malformation                     |                                        X              X                  |      2     |
      Medulla, Hyperplasia                 |                               2                    2           2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                         3|      2  2.5|
      Pars Distalis, Cyst                  |          X                       X  X                             X      |      5     |
      Pars Distalis, Hyperplasia           |                                           1                              |      4  2.0|
      Pars Intermedia, Angiectasis         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ultimobranchial Cyst                 |                                        X  X                              |      2     |
      C-Cell, Hyperplasia                  |                                        1                 1               |      4  1.8|
      Follicle, Pigmentation               |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |                            2                                         1   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ectasia                              |                                     2        4                 3         |      6  3.2|
      Hyperplasia                          |                                              4     3                     |      3  3.0|
      Inflammation, Chronic                |    2           3     2  3                 3           2  2  2           2|     16  2.3|
      Inflammation, Suppurative            |                         2  2              3  4     3     2     2        2|     13  2.6|
      Metaplasia, Squamous                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |                            2                    3                 2     2|      4  2.3|
      Foreign Body                         |                                              2                           |      1  2.0|
      Inflammation, Granulomatous          |                                              4                           |      1  4.0|
      Inflammation, Suppurative            | 2  2                    2  3           3     3              4           2|     18  2.4|
      Epithelium, Hyperplasia              |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                        +                       +         |   4        |
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Atrophy         |       3                                         2              3         |      6  3.0|
      Seminiferous Tubule, Mineralization  |          2  2     3  2                 2  2        2              3  2  3|     20  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Hyperplasia                          |                                              3                           |      2  2.5|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  1.0|
      Myelofibrosis                        |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphatic, Mandibular, Ectasia       |                3                                            2            |      4  2.8|
      Mandibular, Hyperplasia, Lymphoid    |          3                                               3               |      2  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                   3  3                 3     2                    2      |      7  2.4|
      Mediastinal, Erythrophagocytosis     |       3                                                  3     4         |      3  3.3|
      Mediastinal, Hemorrhage              |                                              3                 4         |      4  3.3|
      Mediastinal, Hyperplasia, Histiocytic|                                                 3                        |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |          2                                                               |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |          4                                                        3      |      3  3.3|
      Mediastinal, Lymphatic, Ectasia      |                                     3           3                        |      2  3.0|
      Mesenteric, Atrophy                  |                                                 3                        |      2  3.0|
      Mesenteric, Hemorrhage               |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2              3                                      3            |      3  2.7|
      Fibrosis                             |                2                          3     3           2            |      6  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                              3  2                        |      8  2.3|
      Necrosis                             |                                           3                              |      2  3.5|
      Pigmentation, Hemosiderin            |                                                             3            |      1  3.0|
      Lymphatic, Ectasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  M  M  M  M  +  M  +  +  +  I  M  M  M  M  +  +  +  +  +  +  +|  29        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  44        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  |                               1        2  2     2           1  1  2      |     13  1.7|
      Hyperplasia, Lobular                 |                3                                                         |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |          2                                            2  2               |      4  2.3|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |                                              2                           |      1  2.0|
      Hyperkeratosis                       |                                                       3  2               |      3  2.3|
      Inflammation, Chronic                |          3                                               3  3            |      3  3.0|
      Inflammation, Suppurative            |          2                                                               |      2  2.5|
      Necrosis                             |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             3                                                            |      1  3.0|
      Necrosis                             |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
      Inflammation, Suppurative            |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  2.0|
      Degeneration, Multiple               |       3  3        2                    3                       3  4      |      8  2.8|
      Cerebrum, Degeneration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                3     2              2                                    |      4  2.3|
      Edema, Diffuse                       | 2                                   3                                    |      2  2.5|
      Foreign Body                         | 2     2                                                                  |      6  2.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |    1        1     1  2  1           3  1        1  1  1           1  1  1|     27  1.3|
      Inflammation, Chronic                |          2                             3                                 |      2  2.5|
      Inflammation, Granulomatous          |       3                                                                  |      2  2.5|
      Metaplasia, Osseous                  |                                                 1                        |      1  1.0|
      Pigmentation                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05049-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             DICHLORVOS                                        Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 11:18:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3|            |
                                           | 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    4.0                                    | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Artery, Media, Hypertrophy           |    2                                         2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Foreign Body                  |                   3                                                      |      1  3.0|
      Lumen, Fungus                        |                                                                          |      1  3.0|
      Lumen, Hemorrhage                    |                                                                          |      1  2.0|
      Lumen, Inflammation, Suppurative     |                   3                 2                                    |      3  2.3|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             2                                                            |      2  2.0|
      Nasopharyngeal Duct, Foreign Body    |                   3                                                      |      1  3.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                   2                                                      |      1  2.0|
      Submucosa, Inflammation, Chronic     |                   2                                                      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                         M|            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +        M                           |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                     2                                    |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |          2  3  2  2     2  2     3  3  2     2     4  4  3  3  2  3  2  2|     30  2.5|
      Inflammation, Suppurative            |                   1                 1              2     2               |      6  1.5|
      Nephropathy                          | 1  2  2  2  3  3  3  2  3  2  1  3  3  3  3  2  1  4  3  3  4  2  3  2  2|     49  2.3|
      Pelvis, Mineralization               |                                                 2                        |      1  2.0|
      Pelvis, Epithelium, Hyperplasia      |                                                 3                        |      1  3.0|
      Renal Tubule, Mineralization         |             1           1           2     1              1     1  1     1|     12  1.2|
      Renal Tubule, Pigmentation           |                                              2                           |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
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