https://ntp.niehs.nih.gov/go/2657

TDMS Study 05052-02 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         2,4-DICHLOROPHENOL
NTP Experiment-Test: 05052-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 23:50:15
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  120-83-2
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4           10            5                                                  
    Moribund                                           1                         2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           40           43                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (46)                      (45)                                                
      Papilloma                                        1 (2%)                                                                       
   Intestine Small                                    (48)         (2)          (47)                                                
   Liver                                              (50)         (6)          (50)                                                
      Hepatocellular Carcinoma                         2 (4%)                    1 (2%)                                             
      Hepatocellular Adenoma                                        2 (33%)                                                         
   Mesentery                                          (47)         (1)          (48)                                                
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Pancreas                                           (49)                      (47)                                                
   Salivary Glands                                    (49)                      (47)                                                
   Stomach                                            (49)         (14)         (48)                                                
      Forestomach, Squamous Cell Carcinoma             1 (2%)                                                                       
      Forestomach, Squamous Cell Papilloma             3 (6%)       3 (21%)                                                         
      Glandular, Hepatocellular Carcinoma,                                                                                          
          Metastatic                                   1 (2%)                                                                       
   Tooth                                              (48)                      (44)                                                
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland                                      (49)         (1)          (50)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Medulla, Pheochromocytoma Benign                 2 (4%)                    2 (4%)                                             
      Spindle Cell, Adenoma                            1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (49)                      (47)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)                      (48)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenocarcinoma                                              1 (2%)                                             
      Pars Distalis, Adenoma                           4 (8%)                    3 (6%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)                      (47)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (48)         (22)         (48)                                                
      Choriocarcinoma                                                            1 (2%)                                             
      Cystadenoma                                                                1 (2%)                                             
      Granulosa Cell Tumor                                          1 (5%)       1 (2%)                                             
   Uterus                                             (49)         (40)         (49)                                                
      Polyp Stromal                                    2 (4%)       2 (5%)       1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Blood                                              (13)                      (7)                                                 
   Bone Marrow                                        (50)                      (50)                                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
   Lymph Node                                         (48)         (9)          (46)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Spleen                                             (49)         (9)          (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
   Thymus                                             (47)         (1)          (42)                                                
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (19)         (1)          (29)                                                
      Adenocarcinoma                                   1 (5%)                                                                       
      Basosquamous Tumor Benign                                     1 (100%)                                                        
   Skin                                               (48)         (1)          (49)                                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Liposarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (50)         (2)          (50)                                                
   Skeletal Muscle                                                 (2)          (1)                                                 
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)                      (48)                                                
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (1)          (50)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (100%)     2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
   Nose                                               (48)                      (44)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Ear                                                (1)                                                                           
      Schwannoma Malignant                             1 (100%)                                                                     
   Harderian Gland                                    (35)         (2)          (41)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          1 (3%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (49)                      (50)                                                
   Urinary Bladder                                    (48)                      (47)                                                
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   3 (6%)                                                                       
      Lymphoma Malignant Lymphocytic                   6 (12%)      3 (6%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       3 (6%)       2 (4%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    1 (2%)                                             
      Mesothelioma Benign                              1 (2%)                                                                       
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            26          14          22                                                   
     Total Primary Neoplasms                           38          16          28                                                   
   Total Animals with Benign Neoplasms                 16           8          10                                                   
     Total Benign Neoplasms                            19           9          15                                                   
   Total Animals with Malignant Neoplasms              16           6          12                                                   
     Total Malignant Neoplasms                         19           6          12                                                   
   Total Animals with Metastatic Neoplasms              3                       3                                                   
     Total Metastatic Neoplasm                          3                       8                                                   
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              12           14           12                                                  
    Moribund                                           5            4            3                                                  
    Drowned                                                                      4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (42)                      (40)                                                
   Intestine Large                                    (48)         (1)          (45)                                                
   Intestine Small                                    (44)         (1)          (41)                                                
   Liver                                              (50)         (49)         (48)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                         5 (10%)      7 (14%)      3 (6%)                                             
      Hepatocellular Carcinoma, Trabecular,                                                                                         
          Multiple                                     1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           3 (6%)       5 (10%)      6 (13%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Mesentery                                          (21)         (1)          (37)                                                
   Pancreas                                           (49)                      (45)                                                
   Salivary Glands                                    (50)                      (49)                                                
   Stomach                                            (48)         (6)          (46)                                                
      Forestomach, Squamous Cell Carcinoma                                       1 (2%)                                             
      Forestomach, Squamous Cell Papilloma                                       2 (4%)                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (1)          (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland                                      (49)                      (45)                                                
      Medulla, Pheochromocytoma Benign                                           1 (2%)                                             
      Spindle Cell, Adenoma                            1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)                      (48)                                                
      Follicular Cell, Adenoma                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (48)                      (48)                                                
   Penis                                              (5)          (4)          (2)                                                 
      Sarcoma                                          1 (20%)                                                                      
   Preputial Gland                                    (10)         (5)          (9)                                                 
      Sarcoma                                          1 (10%)                                                                      
   Prostate                                           (48)         (49)         (49)                                                
   Testes                                             (48)         (1)          (48)                                                
      Interstitial Cell, Adenoma                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node                                         (48)         (11)         (47)                                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (49)         (46)         (47)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (38)                      (38)                                                
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (50)         (21)         (49)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       5 (24%)      2 (4%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             5 (24%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Leiomyosarcoma              1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     5 (10%)      3 (14%)      1 (2%)                                             
      Subcutaneous Tissue, Sarcoma, Multiple           2 (4%)       1 (5%)                                                          
      Tail, Subcutaneous Tissue, Sarcoma                            1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                                 (1)                                                              
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (4)          (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (25%)                                                         
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (25%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (25%)                                                         
      Fibrosarcoma, Metastatic, Skin                                1 (25%)                                                         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (44)         (3)          (30)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          2 (5%)       2 (67%)      4 (13%)                                            
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (49)         (6)          (49)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (17%)                                                         
   Urinary Bladder                                    (48)         (3)          (46)                                                
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)       2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                    3 (6%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            29          29          24                                                   
     Total Primary Neoplasms                           39          37          33                                                   
   Total Animals with Benign Neoplasms                 11          13          16                                                   
     Total Benign Neoplasms                            13          14          21                                                   
   Total Animals with Malignant Neoplasms              21          21          10                                                   
     Total Malignant Neoplasms                         26          23          12                                                   
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           5                                                               
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
--multipart-boundary
Content-type: text/plain
Range: bytes 57149-57149/57149
--multipart-boundary--