National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2657

TDMS Study 05052-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         2,4-DICHLOROPHENOL


NTP Experiment-Test: 05052-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 23:50:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-83-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4           10            5                                                  
    Moribund                                           1                         2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           40           43                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)                      (45)                                                
      Papilloma                                        1 (2%)                                                                       
   Intestine Small                                    (48)         (2)          (47)                                                
   Liver                                              (50)         (6)          (50)                                                
      Hepatocellular Carcinoma                         2 (4%)                    1 (2%)                                             
      Hepatocellular Adenoma                                        2 (33%)                                                         
   Mesentery                                          (47)         (1)          (48)                                                
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Pancreas                                           (49)                      (47)                                                
   Salivary Glands                                    (49)                      (47)                                                
   Stomach                                            (49)         (14)         (48)                                                
      Forestomach, Squamous Cell Carcinoma             1 (2%)                                                                       
      Forestomach, Squamous Cell Papilloma             3 (6%)       3 (21%)                                                         
      Glandular, Hepatocellular Carcinoma,                                                                                          
          Metastatic                                   1 (2%)                                                                       
   Tooth                                              (48)                      (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (1)          (50)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Medulla, Pheochromocytoma Benign                 2 (4%)                    2 (4%)                                             
      Spindle Cell, Adenoma                            1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (49)                      (47)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)                      (48)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenocarcinoma                                              1 (2%)                                             
      Pars Distalis, Adenoma                           4 (8%)                    3 (6%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)                      (47)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (22)         (48)                                                
      Choriocarcinoma                                                            1 (2%)                                             
      Cystadenoma                                                                1 (2%)                                             
      Granulosa Cell Tumor                                          1 (5%)       1 (2%)                                             
   Uterus                                             (49)         (40)         (49)                                                
      Polyp Stromal                                    2 (4%)       2 (5%)       1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (13)                      (7)                                                 
   Bone Marrow                                        (50)                      (50)                                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
   Lymph Node                                         (48)         (9)          (46)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Spleen                                             (49)         (9)          (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
   Thymus                                             (47)         (1)          (42)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (19)         (1)          (29)                                                
      Adenocarcinoma                                   1 (5%)                                                                       
      Basosquamous Tumor Benign                                     1 (100%)                                                        
   Skin                                               (48)         (1)          (49)                                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Liposarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (2)          (50)                                                
   Skeletal Muscle                                                 (2)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (1)          (50)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (100%)     2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Liposarcoma, Metastatic, Skin                                              1 (2%)                                             
   Nose                                               (48)                      (44)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Schwannoma Malignant                             1 (100%)                                                                     
   Harderian Gland                                    (35)         (2)          (41)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          1 (3%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)                      (50)                                                
   Urinary Bladder                                    (48)                      (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   3 (6%)                                                                       
      Lymphoma Malignant Lymphocytic                   6 (12%)      3 (6%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       3 (6%)       2 (4%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    1 (2%)                                             
      Mesothelioma Benign                              1 (2%)                                                                       
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            26          14          22                                                   
     Total Primary Neoplasms                           38          16          28                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16           8          10                                                   
     Total Benign Neoplasms                            19           9          15                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16           6          12                                                   
     Total Malignant Neoplasms                         19           6          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       3                                                   
     Total Metastatic Neoplasm                          3                       8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              12           14           12                                                  
    Moribund                                           5            4            3                                                  
    Drowned                                                                      4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)                      (40)                                                
   Intestine Large                                    (48)         (1)          (45)                                                
   Intestine Small                                    (44)         (1)          (41)                                                
   Liver                                              (50)         (49)         (48)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                         5 (10%)      7 (14%)      3 (6%)                                             
      Hepatocellular Carcinoma, Trabecular,                                                                                         
          Multiple                                     1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           3 (6%)       5 (10%)      6 (13%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Mesentery                                          (21)         (1)          (37)                                                
   Pancreas                                           (49)                      (45)                                                
   Salivary Glands                                    (50)                      (49)                                                
   Stomach                                            (48)         (6)          (46)                                                
      Forestomach, Squamous Cell Carcinoma                                       1 (2%)                                             
      Forestomach, Squamous Cell Papilloma                                       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)                      (45)                                                
      Medulla, Pheochromocytoma Benign                                           1 (2%)                                             
      Spindle Cell, Adenoma                            1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)                      (48)                                                
      Follicular Cell, Adenoma                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)                      (48)                                                
   Penis                                              (5)          (4)          (2)                                                 
      Sarcoma                                          1 (20%)                                                                      
   Preputial Gland                                    (10)         (5)          (9)                                                 
      Sarcoma                                          1 (10%)                                                                      
   Prostate                                           (48)         (49)         (49)                                                
   Testes                                             (48)         (1)          (48)                                                
      Interstitial Cell, Adenoma                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (48)         (11)         (47)                                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (49)         (46)         (47)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (38)                      (38)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (21)         (49)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       5 (24%)      2 (4%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             5 (24%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Leiomyosarcoma              1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     5 (10%)      3 (14%)      1 (2%)                                             
      Subcutaneous Tissue, Sarcoma, Multiple           2 (4%)       1 (5%)                                                          
      Tail, Subcutaneous Tissue, Sarcoma                            1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (4)          (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (25%)                                                         
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (25%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (25%)                                                         
      Fibrosarcoma, Metastatic, Skin                                1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (44)         (3)          (30)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          2 (5%)       2 (67%)      4 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (6)          (49)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (17%)                                                         
   Urinary Bladder                                    (48)         (3)          (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)       2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                    3 (6%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05052-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 23:50:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            29          29          24                                                   
     Total Primary Neoplasms                           39          37          33                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11          13          16                                                   
     Total Benign Neoplasms                            13          14          21                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          21          10                                                   
     Total Malignant Neoplasms                         26          23          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2                                                               
     Total Metastatic Neoplasm                          1           5                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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