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TDMS Study 05052-02 Pathology Tables

NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 11:10:40




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-83-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Mucosa, Cyst                         |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Inflammation,  |                                                                          |             
           Acute, Focal                    |                                                                          |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid, Multifocal            |             3                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X                                                                        |             
      Basophilic Focus, Single             |                                                 X                       X|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                            2                                             |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
      Inflammation, Multifocal, Subacute   |       1                                                                  |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Hepatocyte, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
      Hepatocyte, Inflammation, Multifocal,|                                                                          |             
           Necrotizing, Subacute           |                                                             2            |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                   2                                                      |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Left Lateral Lobe, Angiectasis, Focal|                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                            2                                             |             
      Thrombosis                           |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multifocal                     |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |       2                                                                  |             
      Acinus, Atrophy, Multifocal          |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Erosion, Focal          |                                                                          |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           | 4           2     4                                4     4     4         |             
      Mucosa, Glandular, Mineralization,   |                                                                          |             
           Diffuse                         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Focal                    |       3                                                                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Focal, Granulomatous            |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Focal, Necrotizing              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Focal Cellular Change        |                         2              2                                 |             
      Cortex, Hyperplasia, Focal           |       2                                      1                           |             
      Medulla, Hyperplasia, Focal          |       3     2                                                            |             
      Medulla, Hypertrophy                 |                                                                          |             
      Spindle Cell, Hyperplasia, Diffuse   | 2  3     2  2     2     2  2  2     2  2  2  2  2  2  2  2  2  2  2  3  2|             
      Spindle Cell, Hyperplasia, Multifocal|       2                                                                  |             
      Subcapsular, Cyst                    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  M  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          3              2  1                                             |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                   2                                2                     |             
      Pars Intermedia, Hyperplasia, Focal  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Follicle, Cyst, Multiple             |                            X                                             |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Diffuse                 |                                                                          |             
      Cyst                                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Abscess, Chronic Active,  |                                                                          |             
           Multifocal                      |                            4                                             |             
      Bilateral, Periovarian Tissue, Cyst  |                                                       X                  |             
      Follicle, Cyst                       |                                                                          |             
      Left, Follicle, Cyst                 |                                           X  X                           |             
      Periovarian Tissue, Cyst             |                                                                          |             
      Periovarian Tissue, Right, Cyst      |                                                                          |             
      Periovarian Tissue, Left, Cyst       |                                                             X            |             
      Right, Follicle, Cyst                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Angiectasis, Focal      |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse, Glandular              | 3  3  3  3  4  2  2  3  3  2  3     2  3  3  3  3  3  3  2  3  3  2  3  3|             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
      Lumen, Dilatation, Diffuse           |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +           +        +  +                                +     +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Diffuse,     |                                                                          |             
           Lymphoid                        |                                           3                              |             
      Lumbar, Sinus, Ectasia, Focal        | 3                                                                        |             
      Mediastinal, Pigmentation, Diffuse   |                                                                          |             
      Mesenteric, Angiectasis, Diffuse     |       2                       2                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Diffuse                |                2                    2                                    |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Diffuse, Lymphoid                |                                                                      3   |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid                         |                                           3                              |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid, Multifocal             |                                                             2            |             
      Red Pulp, Angiectasis, Multifocal    |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                            3                                      2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Depletion Lymphoid, Diffuse          |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  +  M  +  M  +  M  M  M  M  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Face, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Focal,             |                                                                          |             
          Granulomatous                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Myelofibrosis, Multifocal   |                                                                      2   |             
      Femur, Myelofibrosis, Diffuse        | 3                                                  4                     |             
      Femur, Myelofibrosis, Focal          |                                                             1            |             
      Femur, Myelofibrosis, Multifocal     |    2     2              2  2     2           2                 1  3     2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                 4                        |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Multifocal, Lymphocyte          |             2                                               2            |             
      Thalamus, Mineralization             |                         1                       2           2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2                                                               |             
      Inflammation, Focal, Granulomatous   |          1                                                               |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             3     1                    1                                 |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                                   3      |             
      Vein, Intima, Mineralization, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                   2                                                      |             
      Submucosa, Glands, Ectasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +     +  +        +        +  +  +  +     +        +        +|             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Multifocal,   |                                                                          |             
           Subacute                        |                            2                                             |             
      Cortex, Infarct, Chronic             |                                                                          |             
      Cortex, Metaplasia, Focal, Osseous   |    2                                                                     |             
      Glomerulus, Inflammation, Diffuse,   |                                                                          |             
           Proliferative                   |                                     3                                    |             
      Renal Tubule, Casts Protein, Diffuse |                                     2                                    |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Diffuse                         |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Degeneration, Diffuse  |                                     3                                    |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Regeneration, Focal    |       2                                                                  |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Mucosa, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Ileum, Peyer's Patch, Inflammation,  |                                                                          |            |
           Acute, Focal                    |    2                                                                     |      1  2.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Basophilic Focus, Single             |                                                                          |      2     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  1.0|
      Hepatocyte, Hyperplasia, Focal       |             2                                                            |      1  2.0|
      Hepatocyte, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                   1  1                                                   |      2  1.0|
      Hepatocyte, Inflammation, Multifocal,|                                                                          |            |
           Necrotizing, Subacute           |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       |                      2                                                   |      1  2.0|
      Left Lateral Lobe, Angiectasis, Focal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  47        |
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Thrombosis                           |                      X                                                   |      1     |
      Fat, Necrosis, Focal                 |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst, Multifocal                     |                      3                                                   |      1  3.0|
      Acinus, Atrophy, Diffuse             |                      4                                                   |      1  4.0|
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Erosion, Focal          |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                              4  2           4     4      |     10  3.6|
      Mucosa, Glandular, Mineralization,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Focal                    |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Focal, Granulomatous            |    3                                                                     |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Focal, Necrotizing              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cortex, Focal Cellular Change        |       1                                                                  |      3  1.7|
      Cortex, Hyperplasia, Focal           |                                                                          |      2  1.5|
      Medulla, Hyperplasia, Focal          |                                                                          |      2  2.5|
      Medulla, Hypertrophy                 |                                                             1            |      1  1.0|
      Spindle Cell, Hyperplasia, Diffuse   | 2  2  2     2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2|     45  2.0|
      Spindle Cell, Hyperplasia, Multifocal|                                                                          |      1  2.0|
      Subcapsular, Cyst                    |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  39        |
      Cyst                                 |                                                       X                  |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis, Focal    |             2                                                            |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                          2               |      3  2.0|
      Pars Intermedia, Hyperplasia, Focal  |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |       X                                                                  |      1     |
      Follicle, Cyst, Multiple             |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis, Diffuse                 |                                  2                                       |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Bilateral, Abscess, Chronic Active,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      1     |
      Follicle, Cyst                       |                                     X                          X         |      2     |
      Left, Follicle, Cyst                 |                                                                          |      2     |
      Periovarian Tissue, Cyst             |                                  X                                       |      1     |
      Periovarian Tissue, Right, Cyst      |       X        X           X              X                              |      4     |
      Periovarian Tissue, Left, Cyst       |          X                                                           X   |      3     |
      Right, Follicle, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Endometrium, Angiectasis, Focal      |                                           2                              |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse, Glandular              | 2  2  2  3  2  2  2  3  3  3  3  3  3  3  3  3  2  3  3  3  2  2  3     2|     48  2.7|
      Endometrium, Metaplasia, Squamous    |                                                 2                        |      1  2.0|
      Lumen, Dilatation                    |                                                       X              X   |      2     |
      Lumen, Dilatation, Diffuse           | 3                                                                        |      1  3.0|
      Lumen, Dilatation                    |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                 +                       +  +     +              +  +|  13        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Bronchial, Hyperplasia, Diffuse,     |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
      Lumbar, Sinus, Ectasia, Focal        |                                                                          |      1  3.0|
      Mediastinal, Pigmentation, Diffuse   |                      2                                                   |      1  2.0|
      Mesenteric, Angiectasis, Diffuse     |                                                          2           3   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphoid, Diffuse                |                                                                          |      2  2.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Diffuse, Lymphoid                |          3                                                               |      2  3.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  2.0|
      Red Pulp, Angiectasis, Multifocal    |       2                                                                  |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                3                                                     3   |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy, Diffuse                     |                                                                3         |      1  3.0|
      Depletion Lymphoid, Diffuse          |                3                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  M  M  M  M  M  M  M  M  +  M  M  +  M  +  M  +  +  M  +  M  +|  19        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Face, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Focal,             |                                                                          |            |
          Granulomatous                    |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Myelofibrosis, Multifocal   |                                                                          |      1  2.0|
      Femur, Myelofibrosis, Diffuse        |                                                                          |      2  3.5|
      Femur, Myelofibrosis, Focal          | 1                                                        2  2            |      4  1.5|
      Femur, Myelofibrosis, Multifocal     |       3  2  2        2  2  2        2  2                          2     2|     19  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                                                          |      1  4.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Lymphocyte          |    2                                                                     |      3  2.0|
      Thalamus, Mineralization             |                                                 1                        |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Inflammation, Focal, Subacute        |                                           2                              |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  1.7|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      1  3.0|
      Vein, Intima, Mineralization, Focal  |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mucosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Submucosa, Glands, Ectasia,          |                                                                          |            |
          Multifocal                       |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   1        |
      Developmental Malformation           |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +|  35        |
      Hyperplasia, Focal                   |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Multifocal,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Cortex, Infarct, Chronic             |                                                 2                        |      1  2.0|
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |      1  2.0|
      Glomerulus, Inflammation, Diffuse,   |                                                                          |            |
           Proliferative                   |                                                                          |      1  3.0|
      Renal Tubule, Casts Protein, Diffuse |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Diffuse                         |                                                                      3   |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Multifocal                      |                2                                                         |      1  2.0|
      Renal Tubule, Degeneration, Diffuse  |                                                                          |      1  3.0|
      Renal Tubule, Degeneration           |                                                 1                        |      1  1.0|
      Renal Tubule, Regeneration, Focal    |                               1                    1                     |      3  1.3|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                         2                                         2      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 7| 4| 9| 9| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 9| 8| 2| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Diffuse, Lymphoid               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +              +  +              A            |             
      Eosinophilic Focus, Single           |                                                                          |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Chronic, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                            +                                             |             
      Palate, Epithelium, Hyperplasia      |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                                +  +  +  +  +  +  +                     |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                  4  4  4  4     4  4                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +     +  +        +  +     +  +        +     +     +     +   |             
      Bilateral, Abscess, Chronic Active,  |                                                                          |             
           Multifocal                      |                   4                                                      |             
      Bilateral, Periovarian Tissue, Cyst  |                                                    X                     |             
      Follicle, Cyst                       |                      X                 X                                 |             
      Left, Abscess, Chronic, Focal        |                               3                                          |             
      Left, Follicle, Cyst                 |                                                                          |             
      Periovarian Tissue, Cyst             |                      X                 X                 X               |             
      Periovarian Tissue, Right, Cyst      |             X     X                       X                          X   |             
      Periovarian Tissue, Left, Cyst       | X                                                                        |             
      Right, Abscess, Chronic Active,      |                                                                          |             
          Single                           |    3                                                                     |             
      Right, Follicle, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +        A  +     +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse, Glandular              | 3  2  3  3  3  3  2  3  3  3     2  3  2  3  3  3  3                 3  3|             
      Endometrium, Inflammation, Focal,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 5| 6| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 7| 4| 9| 9| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 9| 8| 2| 0| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +     +                                   A  +         |             
      Lumbar, Hyperplasia, Diffuse,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Mesenteric, Angiectasis, Multifocal  |                         2                                                |             
      Mesenteric, Hyperplasia, Diffuse,    |                                                                          |             
           Lymphoid                        |                   2                                                      |             
      Renal, Hyperplasia, Diffuse, Lymphoid|                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +  +        +                                A            |             
      Inflammation, Chronic                |                                                                          |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Diffuse, Lymphoid                |                   3                                                      |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       I                                                        +         |             
      Vertebra, Myelofibrosis, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Thoracic, Hemorrhage, Acute, Focal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                                               +                  |   2        |
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Diffuse, Lymphoid               |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |          +                                                  +           +|   6        |
      Eosinophilic Focus, Single           |                                                             X            |      1     |
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                                                                         3|      1  3.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Fat, Necrosis, Chronic, Focal        |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Epithelium, Hyperplasia      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                       +  +  +                    +                 +   |  14        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           | 4                       4  2                                         4   |     10  3.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +  +  +        +           +        +           +         |  22        |
      Bilateral, Abscess, Chronic Active,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Bilateral, Periovarian Tissue, Cyst  |                               X                                          |      2     |
      Follicle, Cyst                       |                                                                          |      2     |
      Left, Abscess, Chronic, Focal        |                                           3                              |      2  3.0|
      Left, Follicle, Cyst                 |                X                                                         |      1     |
      Periovarian Tissue, Cyst             |                                                                          |      3     |
      Periovarian Tissue, Right, Cyst      |             X                                                  X         |      6     |
      Periovarian Tissue, Left, Cyst       |                   X  X                             X                     |      4     |
      Right, Abscess, Chronic Active,      |                                                                          |            |
          Single                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Right, Follicle, Cyst                | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +  +     +   |  40        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse, Glandular              | 3  3  3  3  3     3  2     2  2  3     3     2  3  3  3  3  3  3     2   |     38  2.8|
      Endometrium, Inflammation, Focal,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                             +                                      +|   9        |
      Lumbar, Hyperplasia, Diffuse,        |                                                                          |            |
          Lymphoid                         |    2                                                                     |      1  2.0|
      Mesenteric, Angiectasis, Multifocal  |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Diffuse,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Renal, Hyperplasia, Diffuse, Lymphoid|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +           +           +                                      +|   9        |
      Inflammation, Chronic                |                                  4                                       |      1  4.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Diffuse, Lymphoid                |                                                                          |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                         3|      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                                                                     |   2        |
      Vertebra, Myelofibrosis, Multifocal  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
      Thoracic, Hemorrhage, Acute, Focal   |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Single             |                                        X                    X            |             
      Clear Cell Focus                     |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                 2                        |             
      Hepatocyte, Necrosis, Acute, Diffuse |                                                                          |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                               3                                          |             
      Hepatocyte, Nuclear Alteration, Focal|    1                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                           3                              |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                      3                                                   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Hyperplasia, Diffuse   | 2  2  2  2  2  2     2  2  3  2  3  2  2  2  2  2     2  2  2  2  3  3  2|             
      Spindle Cell, Hyperplasia, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                         X|             
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                         X|             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicle, Inflammation, Focal,       |                                                                          |             
          Granulomatous                    |                                        2                                 |             
      Follicle, Inflammation, Multifocal,  |                                                                          |             
           Subacute                        |                                           2                              |             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Bilateral, Periovarian Tissue, Cyst  |                                        X              X                  |             
      Follicle, Cyst                       |       X                                                                 X|             
      Left, Follicle, Cyst                 |                                                                   X      |             
      Periovarian Tissue, Cyst             |                         X           X        X                           |             
      Periovarian Tissue, Right, Cyst      |                                                                          |             
      Periovarian Tissue, Left, Cyst       |                X                                X                    X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Diffuse,        |                                                                          |             
          Glandular                        |                                                                3         |             
      Endometrium, Angiectasis             |             3                                                            |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse, Glandular              | 2  3     2  2  3     3  3  2  1  2  3  2  2  3  3  2  2  3  2     3  3  2|             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
      Lumen, Dilatation, Diffuse           |       4                                                                  |             
      Lumen, Dilatation                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                    +                    +     +                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |             
           Lymphoid                        |                                                                          |             
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |             
           Lymphoid                        |                                                                          |             
      Renal, Hyperplasia, Diffuse, Lymphoid|                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Acute, Diffuse|                                           2                              |             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Diffuse                |                                                                          |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Diffuse, Lymphoid                | 2                    2     3                                             |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Lymphoid, Multifocal             |                                                                2         |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                               2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Diffuse          |                                                                          |             
      Medulla, Hyperplasia, Diffuse,       |                                                                          |             
          Lymphoid                         |                            2                                             |             
      Thymocyte, Necrosis, Acute, Diffuse  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  +  M  +  M  M  M  M  +  M  +  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Myelofibrosis, Focal        |                                                                          |             
      Cranium, Myelofibrosis               |    2                                            2                        |             
      Cranium, Myelofibrosis, Multifocal   |                                                                          |             
      Cranium, Femur, Myelofibrosis,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Cranium, Femur, Myelofibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Femur, Myelofibrosis, Diffuse        |                                        2                                 |             
      Femur, Myelofibrosis, Focal          |          2  2                    2                             1         |             
      Femur, Myelofibrosis, Multifocal     | 2  2  2              2              3     2  2  2        3        1      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thalamus, Mineralization             |                                                 2                       2|             
      Third Ventricle, Infiltration        |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      3                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                         2                                                |             
      Interstitium, Inflammation, Focal,   |                                                                          |             
           Subacute                        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +        +  +  +  +  +     +  +  +  +     +     +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              2                           |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            3                 3                           |             
      Capsule, Inflammation, Diffuse,      |                                                                          |             
          Subacute                         |                                           2                              |             
      Glomerulus, Inflammation, Diffuse,   |                                                                          |             
           Subacute, Membranoproliferative |                                                                          |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Multifocal                      |                                                 2                        |             
      Renal Tubule, Inflammation,          |                                                                          |             
          Multifocal, Necrotizing, Subacute|                                                                          |             
      Renal Tubule, Necrosis, Acute,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Pigmentation, Diffuse  |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |          1           1                          2        1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                           1                              |             
      Submucosa, Infiltration Cellular,    |                                                                          |             
           Multifocal, Lymphocyte          |                      3     2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Single             |                                                                          |      2     |
      Clear Cell Focus                     |          X                                                               |      1     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Hepatocyte, Necrosis, Acute, Diffuse |                                        1                                 |      1  1.0|
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                   1                                                      |      2  2.0|
      Hepatocyte, Nuclear Alteration, Focal|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  48        |
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                2         |      1  2.0|
      Acinus, Atrophy, Diffuse             |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |                                                                   2      |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                              2              3            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |             3                       2  2                                 |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +|  44        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Focal                    |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spindle Cell, Hyperplasia, Diffuse   | 2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2|     47  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Spindle Cell, Hyperplasia, Multifocal|                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  M  M  M  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Pars Distalis, Angiectasis, Focal    |                   2                                                      |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                            2                                3            |      3  2.3|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  47        |
      Follicle, Cyst                       |             X                                                            |      2     |
      Follicle, Cyst, Multiple             |    X                                                                     |      1     |
      Follicle, Inflammation, Focal,       |                                                                          |            |
          Granulomatous                    |                                                                          |      1  2.0|
      Follicle, Inflammation, Multifocal,  |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |             2                                                            |      1  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                2                       2                                 |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                 3                        |      1  3.0|
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      2     |
      Follicle, Cyst                       |          X                       X        X                              |      5     |
      Left, Follicle, Cyst                 |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                X                                   X                     |      5     |
      Periovarian Tissue, Right, Cyst      |    X                                                     X               |      2     |
      Periovarian Tissue, Left, Cyst       |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic, Diffuse,        |                                                                          |            |
          Glandular                        |                                                                          |      1  3.0|
      Endometrium, Angiectasis             |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse, Glandular              | 2  3  3  3  2  3  2  3     2  2  3  2     2  3  3  3  2  3  2  2  1     2|     44  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Metaplasia, Squamous    |                                                             2            |      1  2.0|
      Lumen, Dilatation, Diffuse           |                                                                          |      1  4.0|
      Lumen, Dilatation                    |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                             +           +                        |   7        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  46        |
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |            |
           Lymphoid                        |                                                                3         |      1  3.0|
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |            |
           Lymphoid                        |                                                                3         |      1  3.0|
      Renal, Hyperplasia, Diffuse, Lymphoid|                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Acute, Diffuse|                                                                          |      1  2.0|
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Diffuse                |                                                       3                  |      1  3.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Diffuse, Lymphoid                |                                                                3         |      4  2.5|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                   3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +|  42        |
      Depletion Lymphoid, Diffuse          |                                                                         2|      1  2.0|
      Medulla, Hyperplasia, Diffuse,       |                                                                          |            |
          Lymphoid                         |                                                                3         |      2  2.5|
      Thymocyte, Necrosis, Acute, Diffuse  |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  M  M  M  M|  29        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Myelofibrosis, Focal        | 4                                                                        |      1  4.0|
      Cranium, Myelofibrosis               |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Cranium, Myelofibrosis, Multifocal   |                            2                                             |      1  2.0|
      Cranium, Femur, Myelofibrosis,       |                                                                          |            |
          Diffuse                          |                2              2                                          |      2  2.0|
      Cranium, Femur, Myelofibrosis,       |                                                                          |            |
          Multifocal                       |    4  3                                   2  2  2        2              2|      7  2.4|
      Femur, Myelofibrosis, Diffuse        |                                                                          |      1  2.0|
      Femur, Myelofibrosis, Focal          |                                                             2            |      5  1.8|
      Femur, Myelofibrosis, Multifocal     |                                  2                 2                     |     12  2.1|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  48        |
      Compression, Focal                   |                                        3                                 |      1  3.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Lymphocyte          |                                  2                                       |      1  2.0|
      Thalamus, Mineralization             |                                                             2            |      3  2.0|
      Third Ventricle, Infiltration        |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                                      2                              |      3  2.0|
      Interstitium, Inflammation, Focal,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +|  44        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +|  41        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      |             2                                                  2         |      4  2.5|
      Capsule, Inflammation, Diffuse,      |                                                                          |            |
          Subacute                         |                                                                          |      1  2.0|
      Glomerulus, Inflammation, Diffuse,   |                                                                          |            |
           Subacute, Membranoproliferative |                                                                         3|      1  3.0|
      Interstitial Tissue, Inflammation,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Renal Tubule, Inflammation,          |                                                                          |            |
          Multifocal, Necrotizing, Subacute|       2                                                                  |      1  2.0|
      Renal Tubule, Necrosis, Acute,       |                                                                          |            |
          Multifocal                       |                                                             2            |      1  2.0|
      Renal Tubule, Pigmentation, Diffuse  |                                                                   2      |      1  2.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |          1                                               2              2|      7  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Serosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Submucosa, Infiltration Cellular,    |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Colon, Parasite Metazoan, Single     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  M  +  +  +  +     +  +  +     +  +  M  M  +  A        +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +  +     +  +  +     +  +  +  +  +  A        M        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  M  +  M  +  +     +  +  +     +  M  M  +  +  A        +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis, Acute, Multifocal        |                                                       3                  |             
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |             
           Lymphoid, Multifocal            |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  M  M  +  +  +     +  +  +     +  +  M  +  M  M        +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  M  +  +  +  +     +  +  +     +  +  M  +  +  M        +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +  +  +     +  +  +     +  +  +  +  +           +        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                   X                                                      |             
      Basophilic Focus, Single             |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                         2              2                                 |             
      Hepatocyte, Necrosis, Coagulative,   |                                                                          |             
           Multifocal, Subacute            |                                                                          |             
      Hepatocyte, Nuclear Alteration,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Hepatocyte, Nuclear Alteration, Focal| 1  1           1        1  1        1     2  2           2               |             
      Hepatocyte, Nuclear Alteration,      |                                                                          |             
          Multifocal                       |                               1                                          |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Diffuse                         |    1                          1                       1        1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                 +              +     +  +     +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |             4  4           2           4                                 |             
      Glandular, Dysplasia, Focal          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +        +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Focal                    |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                                                                      2   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic Active, Focal           |                3              2                                3         |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      |                                                 2                        |             
      Pulp, Inflammation, Acute, Focal     |                                        3                 2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Degeneration, Fatty, Focal   |       2                                                                  |             
      Cortex, Focal Cellular Change        |                            X           X                                 |             
      Cortex, Focal Cellular Change,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Cortex, Hyperplasia, Focal           |                            2                                             |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
      Spindle Cell, Hyperplasia, Multifocal| 2                          2                             3               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +     +           +  +     +  +           +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +     +           +  +     +  +           +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  M|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst, Single               |                   X              X              X     X                  |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                2           2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Wall, Inflammation, Acute, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm, Focal               |                                                                          |             
      Inflammation, Chronic, Focal         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                +                             +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess, Chronic, Focal              | 4                                                                 3      |             
      Bilateral, Abscess, Chronic          |                                                                          |             
      Bilateral, Inflammation,             |                                                                          |             
          Granulomatous, Multifocal,       |                                                                          |             
          Suppurative                      |                                  3                                       |             
      Duct, Ectasia, Focal                 |                                                                3         |             
      Duct, Ectasia, Multifocal            |                                                                          |             
      Right, Abscess, Chronic, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +     +        +        +                 +   |             
      Inflammation, Acute, Focal           |                                                                          |             
      Lumen, Dilatation, Diffuse           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy, Focal  |                                                    2                     |             
      Germinal Epithelium, Atrophy,        |                                                                          |             
          Multifocal                       |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +     +           +     +     +     +                 +         |             
      Leukocytosis                         |          3                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                                                                          |             
      Femoral, Hypoplasia, Focal           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Diffuse,      |                                                                          |             
          Lymphoid                         |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Diffuse, Plasma Cell            |                                                                          |             
      Lumbar, Hemorrhage, Acute, Diffuse   |                                  3                                       |             
      Lumbar, Hyperplasia, Diffuse, Plasma |                                                                          |             
          Cell                             |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Diffuse, Plasma Cell             |          2                                                               |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Diffuse, Polymorphonuclear       |                                                             2            |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation, Diffuse           | 2                                                                        |             
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |             
           Lymphoid                        |                                                                2         |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Diffuse, Plasma Cell            |                2                    3                       2            |             
      Mesenteric, Angiectasis, Diffuse     |                3           2     2        2        2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Angiectasis, Multifocal  |                                                                          |             
      Mesenteric, Erythrophagocytosis,     |                                                                          |             
           Diffuse                         |                                                                         2|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation, Diffuse           |                                                             2  2        2|             
      Pancreatic, Inflammation, Acute,     |                                                                          |             
           Diffuse                         |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       M           M  M     M                       M           M        M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +  +  +  +     +  +  +     +  +  +     +           +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       M           M  M     M     +              +  M           M        M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  +           M     +                       +           +        +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Fibrosis, Focal             |                                                                          |             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |                                                                          |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Diffuse, Lymphoid                |                                                                          |             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Focal, Lymphoid                  |                            3                                             |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |    3     2              3           4                       3        3   |             
      Red Pulp, Infiltration Cellular,     |                                                                          |             
           Focal, Plasma Cell              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid, Diffuse          |                                        3  2                 3            |             
      Thymocyte, Necrosis, Acute, Diffuse  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Diffuse                  |                                                                          |             
      Acanthosis, Focal                    |                                                                          |             
      Hyperkeratosis, Diffuse              |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Focal, Subacute        |                                                       1                  |             
      Back, Fibrosis, Diffuse              |                                  3                                       |             
      Back, Fibrosis, Focal                |                                                                          |             
      Back, Hyperplasia, Diffuse,          |                                                                          |             
          Pseudoepitheliomatous            |                                                                          |             
      Back, Inflammation, Chronic, Diffuse |                                                                          |             
      Back, Inflammation, Chronic Active,  |                                                                          |             
           Diffuse                         |                                                 2                        |             
      Back, Ulcer, Acute, Diffuse          |                                                                      3   |             
      Back, Ulcer, Acute, Focal            |                3                    2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Back, Ulcer, Chronic Active, Focal   |                                                 3                        |             
      Back, Ulcer, Chronic Active,         |                                                                          |             
          Multifocal                       |                                                          3               |             
      Dermis, Fibrosis, Focal              |                                                                          |             
      Dermis, Inflammation, Focal, Subacute|                                                                          |             
      Face, Ulcer, Chronic Active,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Face, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Focal                           |                                  2                                       |             
      Neck, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Acute, Focal       |                                                 2                        |             
      Prepuce, Ulcer, Acute, Focal         |                                                                          |             
      Right, Inflammation, Chronic Active, |                                                                          |             
           Focal                           |                                              3                           |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute, Focal                    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                          2               |             
      Thoracic, Fibrosis, Focal            |                                                                          |             
      Thoracic, Ulcer, Chronic Active,     |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |             
           Chronic                         | 2  3  3     3  3     3     2     3     2  3              3  3  3     3  3|             
      Joint, Right, Tarsal, Inflammation,  |                                                                          |             
           Chronic Active, Diffuse         |                         3                                                |             
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |             
           Chronic                         |                   2     3     3                 3  2              2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Perivascular Cuffing,    |                                                                          |             
           Focal                           |                                                                          |             
      Meninges, Perivascular Cuffing, Focal|                                                                          |             
      Meninges, Perivascular Cuffing,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Thalamus, Mineralization             |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Diffuse, Subacute        |                                                                          |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                         1|             
      Inflammation, Acute, Multifocal      |                                           2                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                   1  1                          3                 2     2|             
      Capillary, Infiltration Cellular,    |                                                                          |             
           Acute, Diffuse,                 |                                                                          |             
          Polymorphonuclear                |                                                             3            |             
      Capillary, Infiltration Cellular,    |                                                                          |             
           Diffuse, Polymorphonuclear      |                         2                                                |             
      Interstitium, Inflammation,          |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
      Right, Edema, Chronic, Diffuse       |                                           4                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Cyst, Focal                  |                                                                          |             
      Cortex, Infarct, Chronic, Focal      |                                                                         2|             
      Cortex, Inflammation, Acute, Focal   |       1                                                                  |             
      Corticomedullary Junction,           |                                                                          |             
          Angiectasis, Multifocal          |                                              2                           |             
      Corticomedullary Junction,           |                                                                          |             
          Thrombosis, Chronic, Focal       |                                                                          |             
      Left, Inflammation, Chronic Active,  |                                                                          |             
           Diffuse                         |                                                                          |             
      Renal Tubule, Dilatation, Focal      |                                                                          |             
      Renal Tubule, Necrosis, Diffuse,     |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|             
                                           | 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |       1                       1                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Acute,      |                                                                          |             
          Diffuse                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  A  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Colon, Parasite Metazoan, Single     |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M           +                       +        +  +  M           M     M   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +                       +        +  +  M           +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M           +                       +        +  +  M           M     M   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  44        |
      Thrombosis, Acute, Multifocal        |                                                                          |      1  3.0|
      Jejunum, Peyer's Patch, Hyperplasia, |                                                                          |            |
           Lymphoid, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A           +                       +        +  +  M           M     M   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A           +                       +        +  +  M           M     M   |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A           +                       +        +  +  M           +     M   |  21        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Basophilic Focus, Single             |    X                 X                                                   |      2     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                            3                                             |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   |                            2                                             |      1  2.0|
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Hepatocyte, Necrosis, Coagulative,   |                                                                          |            |
           Multifocal, Subacute            |                            3                                             |      1  3.0|
      Hepatocyte, Nuclear Alteration,      |                                                                          |            |
          Diffuse                          |                                                 1           1            |      2  1.0|
      Hepatocyte, Nuclear Alteration, Focal|          1     1  1  1                                1           1      |     15  1.2|
      Hepatocyte, Nuclear Alteration,      |                                                                          |            |
          Multifocal                       |                                     1                                    |      2  1.0|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Diffuse                         |    1        1                    1     1              1     1            |     11  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +     +  +     +  +     +  +  +        +  +  +     +     +|  21        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |             4                                                            |      5  3.6|
      Glandular, Dysplasia, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +     +|  40        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Focal                    |    1     1                                                               |      2  1.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Multifocal               |                                                             3            |      2  2.5|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Focal           |                         2     3  3                                       |      6  2.7|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      1  2.0|
      Pulp, Inflammation, Acute, Focal     |                2                                                         |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Cortex, Degeneration, Fatty, Focal   |                                                                          |      1  2.0|
      Cortex, Focal Cellular Change        |                      X  X                                                |      4     |
      Cortex, Focal Cellular Change,       |                                                                          |            |
          Multifocal                       |                                           X                              |      1     |
      Cortex, Hyperplasia, Focal           |                                     2                 3                  |      3  2.3|
      Medulla, Hyperplasia, Focal          |                2                                                         |      1  2.0|
      Spindle Cell, Hyperplasia, Multifocal|       2     2                 3                          1               |      7  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +                       +        +  +  M           +     +   |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +                       +        +  +  M           +     +   |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +|  38        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst, Single               |                      X                                                   |      5     |
      Follicular Cell, Hyperplasia, Focal  |                                     1                                    |      1  1.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |       +           +                       +                 +            |   4        |
      Wall, Inflammation, Acute, Multifocal|       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|  48        |
      Granuloma Sperm, Focal               |                                              2                           |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                  +  M     +     +|   5        |
      Inflammation, Acute, Focal           |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +                                      +     +  +  M     +      |  10        |
      Abscess, Chronic, Focal              |                                                 4                        |      3  3.7|
      Bilateral, Abscess, Chronic          |          3                                            3                  |      2  3.0|
      Bilateral, Inflammation,             |                                                                          |            |
          Granulomatous, Multifocal,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Duct, Ectasia, Focal                 |                                                                          |      1  3.0|
      Duct, Ectasia, Multifocal            |                                                          2               |      1  2.0|
      Right, Abscess, Chronic, Focal       |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Diffuse         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | A  +  +           +  +        +        +  +  +  +           +     +     +|  17        |
      Inflammation, Acute, Focal           |       2                                                                  |      1  2.0|
      Lumen, Dilatation, Diffuse           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|  48        |
      Germinal Epithelium, Atrophy, Focal  |                                                                          |      1  2.0|
      Germinal Epithelium, Atrophy,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +           +        +        +  +  M            |  12        |
      Leukocytosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                                                                3         |      1  3.0|
      Femoral, Hypoplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Inguinal, Hyperplasia, Diffuse,      |                                                                          |            |
          Lymphoid                         |                         3                                                |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Plasma Cell            |                         3                                                |      1  3.0|
      Lumbar, Hemorrhage, Acute, Diffuse   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hyperplasia, Diffuse, Plasma |                                                                          |            |
          Cell                             |                                              1                           |      1  1.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Diffuse, Plasma Cell             |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Diffuse, Polymorphonuclear       |                                                                          |      1  2.0|
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Diffuse, Plasma Cell            |                                                                          |      3  2.3|
      Mesenteric, Angiectasis, Diffuse     |                         3           2  3              2  2               |     10  2.3|
      Mesenteric, Angiectasis, Multifocal  |                                                             2            |      1  2.0|
      Mesenteric, Erythrophagocytosis,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Diffuse           |       2                                               2                  |      5  2.0|
      Pancreatic, Inflammation, Acute,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M           +                       M        M     M                 M   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M           +                       +        +  +  M           +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M           +                       M        M     M                 M   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M           +                       +        M     M                 M   |   7        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Capsule, Fibrosis, Focal             |                   2                                                      |      1  2.0|
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |                                           2                              |      1  2.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Diffuse, Lymphoid                |                2                                                         |      1  2.0|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Focal, Lymphoid                  |                                                                          |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |       2           2        3                                         2   |     10  2.7|
      Red Pulp, Infiltration Cellular,     |                                                                          |            |
           Focal, Plasma Cell              |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  M  M  +  +  M  M  +  +  +  +  +  +  M  +  +  +|  38        |
      Depletion Lymphoid, Diffuse          |                                                                          |      3  2.7|
      Thymocyte, Necrosis, Acute, Diffuse  | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis, Diffuse                  |                                                                2         |      1  2.0|
      Acanthosis, Focal                    |                                              1                           |      1  1.0|
      Hyperkeratosis, Diffuse              |                                                                2         |      1  2.0|
      Inflammation, Acute, Focal           |                                                                      1   |      1  1.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  1.0|
      Back, Fibrosis, Diffuse              |                                                          3               |      2  3.0|
      Back, Fibrosis, Focal                |                      3                                                   |      1  3.0|
      Back, Hyperplasia, Diffuse,          |                                                                          |            |
          Pseudoepitheliomatous            |                                        3                                 |      1  3.0|
      Back, Inflammation, Chronic, Diffuse |                                        3                                 |      1  3.0|
      Back, Inflammation, Chronic Active,  |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Back, Ulcer, Acute, Diffuse          |                                                                          |      1  3.0|
      Back, Ulcer, Acute, Focal            |                                        2                                 |      3  2.3|
      Back, Ulcer, Chronic Active, Focal   |                                                                          |      1  3.0|
      Back, Ulcer, Chronic Active,         |                                                                          |            |
          Multifocal                       |                      3                                                   |      2  3.0|
      Dermis, Fibrosis, Focal              |                                                 2                        |      1  2.0|
      Dermis, Inflammation, Focal, Subacute|                                              1                           |      1  1.0|
      Face, Ulcer, Chronic Active,         |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
      Face, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Neck, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Acute, Focal       |                                                                          |      1  2.0|
      Prepuce, Ulcer, Acute, Focal         |                                                          3               |      1  3.0|
      Right, Inflammation, Chronic Active, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute, Focal                    |                                                                   2      |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Diffuse                |             2                                                            |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Thoracic, Fibrosis, Focal            |                                                                   3      |      1  3.0|
      Thoracic, Ulcer, Chronic Active,     |                                                                          |            |
           Multifocal                      |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |            |
           Chronic                         |    2  3  2     3  3  3  2     3     3  3  2     3     2  3        3     3|     31  2.7|
      Joint, Right, Tarsal, Inflammation,  |                                                                          |            |
           Chronic Active, Diffuse         |                                                                          |      1  3.0|
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |            |
           Chronic                         |             3              3                 3                           |      9  2.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Perivascular Cuffing,    |                                                                          |            |
           Focal                           |                2                                                         |      1  2.0|
      Meninges, Perivascular Cuffing, Focal|                                        1                                 |      1  1.0|
      Meninges, Perivascular Cuffing,      |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
      Thalamus, Mineralization             |                                                          1               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Diffuse, Subacute        |                                     2                                    |      1  2.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                                              2                           |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                2                                                         |      6  1.8|
      Capillary, Infiltration Cellular,    |                                                                          |            |
           Acute, Diffuse,                 |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Capillary, Infiltration Cellular,    |                                                                          |            |
           Diffuse, Polymorphonuclear      |                                                                          |      1  2.0|
      Interstitium, Inflammation,          |                                                                          |            |
          Multifocal, Subacute             |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7|            |
                             DAY ON TEST   | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Right, Edema, Chronic, Diffuse       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +|  43        |
      Mucosa, Inflammation, Acute          |             2                                                            |      1  2.0|
      Mucosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                         2                                                |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Multifocal               |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +              M            |   1        |
      Atrophy                              |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Cortex, Cyst, Focal                  |                                           X                              |      1     |
      Cortex, Infarct, Chronic, Focal      |                                                                          |      1  2.0|
      Cortex, Inflammation, Acute, Focal   |                                                                          |      1  1.0|
      Corticomedullary Junction,           |                                                                          |            |
          Angiectasis, Multifocal          |                                                                          |      1  2.0|
      Corticomedullary Junction,           |                                                                          |            |
          Thrombosis, Chronic, Focal       |                            3                                             |      1  3.0|
      Left, Inflammation, Chronic Active,  |                                                                          |            |
           Diffuse                         |       3                                                                  |      1  3.0|
      Renal Tubule, Dilatation, Focal      |                                              1                           |      1  1.0|
      Renal Tubule, Necrosis, Diffuse,     |                                                                          |            |
           Subacute                        |                                                                      3   |      1  3.0|
      Renal Tubule, Regeneration, Focal    |                      2                    2              1               |      3  1.7|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |    2     2              2  2     2                                       |      8  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Submucosa, Inflammation, Acute,      |                                                                          |            |
          Diffuse                          | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|             
                                           | 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                    A                    +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Basophilic Focus, Single             |                                                                          |             
      Inflammation, Multifocal, Subacute   |       1                                                                  |             
      Caudate Lobe, Necrosis, Chronic      |                                                                          |             
          Active, Focal                    |                                                                          |             
      Hepatocyte, Cytomegaly, Diffuse      |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                          |             
      Hepatocyte, Cytomegaly, Multifocal   |                                                                          |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                         2                          1        4            |             
      Hepatocyte, Nuclear Alteration, Focal| 1     1  1        1     2     1        1     2     1           1  2  1  2|             
      Hepatocyte, Nuclear Alteration,      |                                                                          |             
          Multifocal                       |             1        1                                                   |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Diffuse                         | 1  2  2  2  2  1     2  2  1  1  2  2  1  1        1     1     1  2  1  2|             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Diffuse, Polymorphonuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                           +        +     +               |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                           4        4     4               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +  +        M                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                    +           +                  |             
      Abscess, Chronic, Focal              |                                           4                              |             
      Duct, Ectasia, Focal                 |                                                       4                  |             
      Duct, Ectasia, Multifocal            |                                                                          |             
      Left, Abscess, Chronic, Focal        |                                                                          |             
      Right, Abscess, Chronic Active, Focal|                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Diffuse                  |    3           3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|             
                                           | 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                         3                                                |             
      Inflammation, Multifocal,            |                                                                          |             
          Necrotizing, Subacute            |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +           +                                             |             
      Dilatation, Diffuse                  |                3           3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +              +        +           +                        |             
      Lumbar, Infiltration Cellular, Focal,|                                                                          |             
           Plasma Cell                     |                            2                                             |             
      Mesenteric, Angiectasis, Diffuse     |          2  2                                                            |             
      Mesenteric, Angiectasis, Multifocal  |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation, Diffuse           |          2                                                               |             
      Pancreatic, Angiectasis, Multifocal  | 2                                   2                                    |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation, Diffuse           | 3                                   1                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |    1                                               3                     |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |       2           3                             2           2  3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +        +  +  +  +     +           +           +        +     +   |             
      Back, Alopecia, Focal                |                                                                          |             
      Prepuce, Inflammation, Acute, Focal  |                                                                          |             
      Prepuce, Inflammation, Acute, Focal, |                                                                          |             
           Necrotizing                     |       3        3                                                         |             
      Prepuce, Inflammation, Acute,        |                                                                          |             
          Multifocal, Necrotizing          |    3                                                                     |             
      Prepuce, Inflammation, Chronic,      |                                                                          |             
          Focal, Necrotizing               |                                                       4                  |             
      Prepuce, Inflammation, Focal,        |                                                                          |             
          Granulomatous, Necrotizing       |                   3  3                                                   |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active, Diffuse                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  M  M  +  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|             
                                           | 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                               3                                          |             
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |             
           Chronic                         | 3  3  3  2        3  2  2     3  2  2     2              2        2  2   |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Diffuse, Osseous                |                                                                          |             
      Joint, Tarsal, Arthrosis, Chronic    |                                              2                           |             
      Joint, Phalanges, Inflammation,      |                                                                          |             
          Chronic Active, Focal            |    3                                                                     |             
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                 +                        |             
      Hemorrhage, Acute, Multifocal        |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +              +                                +         |             
      Infarct, Acute, Multifocal           |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +     +                                                            |             
      Hyperplasia, Focal                   |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +                                                        +         |             
      Inflammation, Multifocal, Subacute   |       3                                                                  |             
      Bilateral, Infarct, Acute, Multifocal|                                                                4         |             
      Bilateral, Inflammation, Acute,      |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
      Corticomedullary Junction, Renal     |                                                                          |             
          Tubule, Mineralization,          |                                                                          |             
          Multifocal                       |    2                                                                     |             
      Pelvis, Inflammation, Acute, Diffuse |       2                                                                  |             
      Renal Tubule, Dilatation, Diffuse    |    2                                                                     |             
      Renal Tubule, Necrosis, Acute,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Right, Atrophy                       |                                                                          |             
      Right, Inflammation, Chronic Active, |                                                                          |             
           Diffuse                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                                                     |             
      Concretion, Focal                    |    3                                                                     |             
      Transitional Epithelium, Necrosis,   |                                                                          |             
           Acute, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|             
                                           | 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +                    A                       A                     |             
      Calculus Gross Observation           |       X                                                                  |             
      Lumen, Ectasia                       |    3                                                                     |             
      Submucosa, Inflammation, Acute,      |                                                                          |             
          Diffuse                          |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8|            |
                                           | 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus, Single             |                X                                                         |      1     |
      Inflammation, Multifocal, Subacute   |                                                                          |      1  1.0|
      Caudate Lobe, Necrosis, Chronic      |                                                                          |            |
          Active, Focal                    |                      4                                                   |      1  4.0|
      Hepatocyte, Cytomegaly, Diffuse      |    3                                                                     |      1  3.0|
      Hepatocyte, Cytomegaly               |                                     3                                    |      1  3.0|
      Hepatocyte, Cytomegaly, Multifocal   |                   3                                                      |      1  3.0|
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |    2                                2     1                              |      6  2.0|
      Hepatocyte, Nuclear Alteration, Focal|       1  1           1  1  2  1           1  1     1        1  1  1  2  1|     27  1.2|
      Hepatocyte, Nuclear Alteration,      |                                                                          |            |
          Multifocal                       |                                                          1               |      3  1.0|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Diffuse                         |             2  2     1  1  1     1     2  1  1     1        1  1  1      |     33  1.4|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Polymorphonuclear      |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Fat, Necrosis, Multifocal            |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +              +                             +            |   6        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                4              4                             4            |      6  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   | +     +                                                                  |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +              +                     |   5        |
      Abscess, Chronic, Focal              |                                                                          |      1  4.0|
      Duct, Ectasia, Focal                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8|            |
                                           | 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Ectasia, Multifocal            |                                                    3                     |      1  3.0|
      Left, Abscess, Chronic, Focal        |                                                    3                     |      1  3.0|
      Right, Abscess, Chronic Active, Focal|                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Dilatation, Diffuse                  |                                                                          |      2  3.0|
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Multifocal,            |                                                                          |            |
          Necrotizing, Subacute            | 3                                                                        |      1  3.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   2        |
      Dilatation, Diffuse                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                 M                        |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +        +           +                       +            |  11        |
      Lumbar, Infiltration Cellular, Focal,|                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Mesenteric, Angiectasis, Diffuse     |                2                                            2            |      4  2.0|
      Mesenteric, Angiectasis, Multifocal  |                         2                                                |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  2.0|
      Pancreatic, Angiectasis, Multifocal  |                                                                          |      2  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  46        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             | 2                                                                    2   |      4  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 2  3              2                 3  2                                2|     11  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +        +              +  +        +        +     +     +  +|  21        |
      Back, Alopecia, Focal                |                      2                                                   |      1  2.0|
      Prepuce, Inflammation, Acute, Focal  |                                                 3                        |      1  3.0|
      Prepuce, Inflammation, Acute, Focal, |                                                                          |            |
           Necrotizing                     |                                                                          |      2  3.0|
      Prepuce, Inflammation, Acute,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8|            |
                                           | 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Multifocal, Necrotizing          |                                                                          |      1  3.0|
      Prepuce, Inflammation, Chronic,      |                                                                          |            |
          Focal, Necrotizing               |                                                                          |      1  4.0|
      Prepuce, Inflammation, Focal,        |                                                                          |            |
          Granulomatous, Necrotizing       |                                                                          |      2  3.0|
      Thoracic, Inflammation, Chronic      |                                                                          |            |
          Active, Diffuse                  |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  M  +|  39        |
      Hyperostosis                         |                                                                          |      1  3.0|
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |            |
           Chronic                         |    2  2  2  2  2  2  2  2  3  2     2     2  2     2  2     2  2  2     2|     33  2.2|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Diffuse, Osseous                |                                                                         2|      1  2.0|
      Joint, Tarsal, Arthrosis, Chronic    |                                                                          |      1  2.0|
      Joint, Phalanges, Inflammation,      |                                                                          |            |
          Chronic Active, Focal            |                                                                          |      1  3.0|
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |            |
           Chronic                         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   1        |
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                           +                              |   4        |
      Infarct, Acute, Multifocal           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                   +      |   3        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                               +        +               |   6        |
      Inflammation, Multifocal, Subacute   |                                                                          |      1  3.0|
      Bilateral, Infarct, Acute, Multifocal|                                                                          |      1  4.0|
      Bilateral, Inflammation, Acute,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8|            |
                                           | 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Multifocal, Suppurative          | 3                                                                        |      1  3.0|
      Corticomedullary Junction, Renal     |                                                                          |            |
          Tubule, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute, Diffuse |                                                                          |      1  2.0|
      Renal Tubule, Dilatation, Diffuse    |                                                 2                        |      2  2.0|
      Renal Tubule, Necrosis, Acute,       |                                                                          |            |
          Diffuse                          |                                                 1                        |      1  1.0|
      Right, Atrophy                       |                                                          4               |      1  4.0|
      Right, Inflammation, Chronic Active, |                                                                          |            |
           Diffuse                         |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                 +                        |   2        |
      Concretion, Focal                    |                                                 3                        |      2  3.0|
      Transitional Epithelium, Necrosis,   |                                                                          |            |
           Acute, Focal                    |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                 +                        |   3        |
      Calculus Gross Observation           |                                                                          |      1     |
      Lumen, Ectasia                       |                                                 3                        |      2  3.0|
      Submucosa, Inflammation, Acute,      |                                                                          |            |
          Diffuse                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Colon, Parasite Metazoan, Single     |                         1                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                             M  M     M  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                             +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                             M  M     M  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                             M        M  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                             M        M  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                             +  A     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                                                       X                  |             
      Basophilic Focus, Single             |       X                       X                                          |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Hepatocyte, Necrosis, Acute, Diffuse | 1              2                                      2                  |             
      Hepatocyte, Necrosis, Acute, Focal   |                                                                          |             
      Hepatocyte, Nuclear Alteration, Focal| 2     1  1  1  1                             1                    1      |             
      Hepatocyte, Syncytial Alteration,    |                                                                          |             
           Diffuse                         | 3  2  2  1        2  2  1  2  3  3  2  2     1  1  2     2  2  2  1  1  2|             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +      |             
      Fat, Necrosis, Acute, Diffuse        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periductular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                               4                 4                        |             
      Glandular, Inflammation, Acute, Focal|                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Focal                    |       2                                                                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                            3                                             |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      | 2  3                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                                                                          |             
      Pulp, Inflammation, Acute, Focal,    |                                                                          |             
           Necrotizing                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pulp, Necrosis, Acute, Diffuse       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal, Suppurative              |                                                                          |             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Myocardium, Inflammation, Multifocal,|                                                                          |             
           Subacute                        |                                                                          |             
      Ventricle Right, Necrosis, Chronic,  |                                                                          |             
           Focal                           |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Accessory Adrenal Cortical Nodule,   |                                                                          |             
           Focal                           |                                                                          |             
      Cortex, Focal Cellular Change        |                      X                       X                           |             
      Cortex, Focal Cellular Change,       |                                                                          |             
          Multifocal                       |    X                                X                                    |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Cortex, Hypertrophy                  |                3                                         2               |             
      Medulla, Hyperplasia, Focal          |                                  2                                       |             
      Spindle Cell, Hyperplasia, Focal     |                                                          2               |             
      Spindle Cell, Hyperplasia, Multifocal|                      2           2              3           2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                             +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                             +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Inflammation, Acute,  |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst, Multiple             |                                  X                                       |             
      Follicle, Cyst, Single               |                         X                                X               |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +     +     +  +     +                       +  +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Inflammation, Diffuse,   |                                                                          |             
           Necrotizing                     |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                     +     +           +|             
      Abscess, Chronic, Focal              |                                                             4            |             
      Abscess, Focal, Subacute             |                                                                         3|             
      Duct, Ectasia, Focal                 | 3                                                     3                  |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Diffuse                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Granuloma, Focal                     |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +     +  +     +        +  +        +                     |             
      Dilatation                           |                                                                          |             
      Lumen, Dilatation, Diffuse           |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
      Parenchyma, Inflammation, Acute,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Serosa, Inflammation, Acute, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy, Diffuse|                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                    +                     |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                         3                                                |             
      Femoral, Thrombosis, Focal, Subacute | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +|             
      Mandibular, Depletion Lymphoid,      |                                                                          |             
          Diffuse                          |                                                             2        3   |             
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |             
           Lymphoid                        |             2                                                            |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Diffuse, Plasma Cell            |    2                                                                     |             
      Mediastinal, Depletion Lymphoid,     |                                                                          |             
           Diffuse                         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Angiectasis, Diffuse     |                         2                                                |             
      Mesenteric, Angiectasis, Multifocal  |                                                                          |             
      Mesenteric, Inflammation, Chronic    |                                                                          |             
      Pancreatic, Angiectasis, Diffuse     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                             M  M        M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                  +                          +  M        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                             +  M        M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             M  M        M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |                                                                2     2  2|             
      Lymphoid Follicle, Hyperplasia,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |             
           Multifocal                      |                                                             2            |             
      Red Pulp, Angiectasis, Multifocal    | 1                                                                        |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |             2                                      2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Diffuse          |             2                                                            |             
      Cortex, Cyst, Single                 |                                     X                                    |             
      Medulla, Cyst, Multiple              |                                                       X                  |             
      Thymocyte, Necrosis, Acute, Diffuse  |                                                             4  4     4  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Acute, Diffuse             |                         3                                                |             
      Abdominal, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                                                                          |             
      Abdominal, Ulcer, Acute, Focal       |                                                                          |             
      Abdominal, Ulcer, Acute, Multifocal  |                                              3                           |             
      Back, Acanthosis, Focal              |                                        2                                 |             
      Back, Fibrosis, Focal                |                                        2  3                              |             
      Back, Fibrosis, Multifocal           |                            3                                             |             
      Back, Ulcer, Acute, Focal            |                                           2                              |             
      Back, Ulcer, Acute, Multifocal       |                            2                                             |             
      Back, Ulcer, Chronic Active,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Face, Subcutaneous Tissue, Granuloma,|                                                                          |             
           Focal                           |                                              2                           |             
      Hindlimb, Subcutaneous Tissue,       |                                                                          |             
          Inflammation, Chronic, Focal,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Granulomatous                   |                                  3                                       |             
      Prepuce, Inflammation, Acute,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Prepuce, Inflammation, Chronic,      |                                                                          |             
          Focal, Necrotizing               |                                                                          |             
      Prepuce, Inflammation, Chronic       |                                                                          |             
          Active, Focal                    |                                                                          |             
      Subcutaneous Tissue, Granuloma, Focal|                                                                         2|             
      Subcutaneous Tissue, Granuloma,      |                                                                          |             
          Multiple                         |                                        1                                 |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute, Diffuse                  |                                  2                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute, Focal                    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                          2               |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active, Focal                    |                                                                          |             
      Thoracic, Ulcer, Chronic Active,     |                                                                          |             
           Multifocal                      |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   X                                                      |             
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |             
           Chronic                         | 2  2     2              3  3  3        3  3     3  2                     |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             |                                                                          |             
      Joint, Left, Tarsal, Metaplasia,     |                                                                          |             
           Multifocal, Osseous             |                                                                          |             
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |             
           Chronic                         |       3     2  2  2  2           2           2           2        2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Inflammation, Acute, Focal |                                                                          |             
      Fourth Ventricle, Lateral Ventricle, |                                                                          |             
           Hydrocephalus                   |                                                                   3      |             
      Lateral Ventricle, Hydrocephalus     |                                              2                           |             
      Thalamus, Mineralization             |                1                 1                          1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Multifocal, Subacute          | 2                                                                        |             
      Foreign Body, Multifocal             |                                                             1  2     2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          3                          2                                    |             
      Diaphragmatic Lobe, Right, Edema,    |                                                                          |             
           Focal, Subacute                 |                            2                                             |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Acute, Diffuse,                 |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Diffuse                         |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          | 3                                                                        |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  M|             
      Septum, Inflammation, Acute, Focal   | 1                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +           +      |             
      Bilateral, Hyperplasia, Multifocal   |                      2                                                   |             
      Right, Hyperplasia, Focal            |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Bilateral, Inflammation, Acute,      |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |             
      Cortex, Renal Tubule, Necrosis,      |                                                                          |             
          Acute, Multifocal                |                                                                      2   |             
      Corticomedullary Junction,           |                                                                          |             
          Metaplasia, Focal, Osseous       |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Mineralization, Multifocal       |                                                                          |             
      Pelvis, Inflammation, Acute,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|             
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
      Pelvis, Mineralization, Focal        |                                                          2               |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Dilatation, Diffuse    |                                                                          |             
      Renal Tubule, Regeneration, Focal    |       1           1        2                                             |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                                    2                 2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Necrosis, Focal, Single      |                                                                          |             
      Serosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  A  A  +  +  +  +  +  +  A  +  +  M  +  +  A  +  +  A  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +|  45        |
      Colon, Parasite Metazoan, Single     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          M        M                    +  M              M     M        M|   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +        +                    +  +              +     +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          M        M                    M  M              M     M        M|            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  A  A  A  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  A  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                           M              M     M        M|            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                           +              M     M        M|   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          A                                +              +     +        +|   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Basophilic Focus, Single             |                                                                          |      2     |
      Inflammation, Multifocal, Subacute   |                         2                                                |      1  2.0|
      Hepatocyte, Necrosis, Acute, Diffuse |                                                                          |      3  1.7|
      Hepatocyte, Necrosis, Acute, Focal   |       2                                                                  |      1  2.0|
      Hepatocyte, Nuclear Alteration, Focal|    1  2           1  1           1  1        1     1  1     1        1   |     18  1.1|
      Hepatocyte, Syncytial Alteration,    |                                                                          |            |
           Diffuse                         | 1  2  2  1        2  2  2  2  2  2  2  2     2  2  2  2  2  2  1     2  1|     42  1.8|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +              +  +  +  +  +  +        +     +  +  +  +  +     +  +|  37        |
      Fat, Necrosis, Acute, Diffuse        |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  45        |
      Acinus, Atrophy, Focal               |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Periductular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                  3                 4                     |      4  3.8|
      Glandular, Inflammation, Acute, Focal|                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +              +     +  +  +  +        +     +  +     +        +   |  34        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Focal                    |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      2  2.5|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Focal, Subacute                 | 2                                                                        |      1  2.0|
      Pulp, Inflammation, Acute, Focal,    |                                                                          |            |
           Necrotizing                     |                                                       3                  |      1  3.0|
      Pulp, Necrosis, Acute, Diffuse       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Focal, Suppurative              |                3                                                         |      1  3.0|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Multifocal                      |                                                          1               |      1  1.0|
      Myocardium, Inflammation, Multifocal,|                                                                          |            |
           Subacute                        |                                        2                                 |      1  2.0|
      Ventricle Right, Necrosis, Chronic,  |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  A  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|  45        |
      Accessory Adrenal Cortical Nodule    |                                                                         X|      1     |
      Accessory Adrenal Cortical Nodule,   |                                                                          |            |
           Focal                           |                      X                                                   |      1     |
      Cortex, Focal Cellular Change        |                      X                             X                     |      4     |
      Cortex, Focal Cellular Change,       |                                                                          |            |
          Multifocal                       |                                                                          |      2     |
      Cortex, Hyperplasia, Focal           |                                                          2               |      1  2.0|
      Cortex, Hypertrophy                  |    3                                                                     |      3  2.7|
      Medulla, Hyperplasia, Focal          |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia, Multifocal|                                                             2            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +        +                    +                       +        +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +        +                    +                       +        +|   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  M  +  +  M  +  M  M  M  +  +  M  +  +  +  M  +  +  +  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Pars Distalis, Inflammation, Acute,  |                                                                          |            |
           Focal                           |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst, Multiple             |                                                       X                  |      2     |
      Follicle, Cyst, Single               |                                                                          |      2     |
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +                 +     +     +  +              +  +     +        +   |  20        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Epithelium, Inflammation, Diffuse,   |                                                                          |            |
           Necrotizing                     |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                        +              +                  |   2        |
      Inflammation, Acute, Focal           |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +     +                       +           +                  |   9        |
      Abscess, Chronic, Focal              |                                                                          |      1  4.0|
      Abscess, Focal, Subacute             |                                                                          |      1  3.0|
      Duct, Ectasia, Focal                 |                                                                          |      2  3.0|
      Duct, Ectasia, Multifocal            |          3                                3           2                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Dilatation, Diffuse                  |                                                                      3   |      1  3.0|
      Dilatation                           |       3                                                                  |      1  3.0|
      Granuloma, Focal                     |          3                                                               |      1  3.0|
      Inflammation, Acute, Diffuse         |                                                          3               |      1  3.0|
      Inflammation, Acute, Multifocal      |             3     2                    3                       3  3      |      5  2.8|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +  +        +        +                             +           +  +|  15        |
      Dilatation                           |       3  4        X                                                      |      3  3.5|
      Lumen, Dilatation, Diffuse           |                                                                      3   |      1  3.0|
      Lumen, Dilatation                    |                                                          3              3|      2  3.0|
      Parenchyma, Inflammation, Acute,     |                                                                          |            |
           Multifocal                      |                                                          2               |      1  2.0|
      Serosa, Inflammation, Acute, Diffuse |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Germinal Epithelium, Atrophy, Diffuse|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +                                                  +     +            |   6        |
      Neutrophilia                         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                                                                          |      1  3.0|
      Femoral, Thrombosis, Focal, Subacute |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mandibular, Depletion Lymphoid,      |                                                                          |            |
          Diffuse                          |                                        3                       2         |      4  2.5|
      Mandibular, Hyperplasia, Diffuse,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Diffuse, Plasma Cell            |                                                                          |      1  2.0|
      Mediastinal, Depletion Lymphoid,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Mesenteric, Angiectasis, Diffuse     | 2                                                  2                     |      3  2.0|
      Mesenteric, Angiectasis, Multifocal  |                                                       2                  |      1  2.0|
      Mesenteric, Inflammation, Chronic    |                         4                                                |      1  4.0|
      Pancreatic, Angiectasis, Diffuse     |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +        +                    +  +              +              +|   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                        +  +                              |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute, Multifocal      |                                                                1         |      1  1.0|
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |          2        2                    2                 3     3     2  2|     10  2.2|
      Lymphoid Follicle, Hyperplasia,      |                                                                          |            |
          Diffuse                          |                                                             3            |      1  3.0|
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Red Pulp, Angiectasis, Multifocal    |                                                                          |      1  1.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                       2                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M  +  M  +  +  +  +  +  M  +  +  M  M  +  M  +  +  M  +  +|  38        |
      Depletion Lymphoid, Diffuse          |                                                                      3   |      2  2.5|
      Cortex, Cyst, Single                 |                                                                          |      1     |
      Medulla, Cyst, Multiple              |                                                                          |      1     |
      Thymocyte, Necrosis, Acute, Diffuse  |          4        3                                            3        2|      8  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis, Acute, Diffuse             |                                                                          |      1  3.0|
      Abdominal, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |    2                                                                     |      1  2.0|
      Abdominal, Ulcer, Acute, Focal       |                                              2                           |      1  2.0|
      Abdominal, Ulcer, Acute, Multifocal  |                                                       2                  |      2  2.5|
      Back, Acanthosis, Focal              | 2                                                                        |      2  2.0|
      Back, Fibrosis, Focal                | 2     2                    2                                             |      5  2.2|
      Back, Fibrosis, Multifocal           |                                                                          |      1  3.0|
      Back, Ulcer, Acute, Focal            |       3                                                                  |      2  2.5|
      Back, Ulcer, Acute, Multifocal       |                                                                          |      1  2.0|
      Back, Ulcer, Chronic Active,         |                                                                          |            |
          Multifocal                       |                                     3                                    |      1  3.0|
      Face, Subcutaneous Tissue, Granuloma,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Hindlimb, Subcutaneous Tissue,       |                                                                          |            |
          Inflammation, Chronic, Focal,    |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
      Prepuce, Inflammation, Acute,        |                                                                          |            |
          Multifocal                       |                                        3                                 |      1  3.0|
      Prepuce, Inflammation, Chronic,      |                                                                          |            |
          Focal, Necrotizing               |                                                       3                  |      1  3.0|
      Prepuce, Inflammation, Chronic       |                                                                          |            |
          Active, Focal                    |                   2                                                      |      1  2.0|
      Subcutaneous Tissue, Granuloma, Focal|                                                                          |      1  2.0|
      Subcutaneous Tissue, Granuloma,      |                                                                          |            |
          Multiple                         |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute, Diffuse                  |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute, Focal                    |                                  1                                       |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                 1                        |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                   2           1                                          |      3  1.7|
      Thoracic, Inflammation, Chronic      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Active, Focal                    |                                              2                           |      1  2.0|
      Thoracic, Ulcer, Chronic Active,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      1     |
      Bilateral, Joint, Tarsal, Arthrosis, |                                                                          |            |
           Chronic                         |    3  2                 3  2  3  2  2                       3            |     18  2.6|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             |                                                       2                  |      1  2.0|
      Joint, Left, Tarsal, Metaplasia,     |                                                                          |            |
           Multifocal, Osseous             |                                                    2                     |      1  2.0|
      Unilateral, Joint, Tarsal, Arthrosis,|                                                                          |            |
           Chronic                         | 2                    2                                                   |     11  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebrum, Inflammation, Acute, Focal |                                                          2               |      1  2.0|
      Fourth Ventricle, Lateral Ventricle, |                                                                          |            |
           Hydrocephalus                   |                                                                          |      1  3.0|
      Lateral Ventricle, Hydrocephalus     |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema, Multifocal, Subacute          |                                                                          |      1  2.0|
      Foreign Body, Multifocal             |                                        2                                 |      5  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                                                                     |      3  2.3|
      Diaphragmatic Lobe, Right, Edema,    |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Acute, Diffuse,                 |                                                                          |            |
          Polymorphonuclear                |                                                 2                        |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Diffuse                         |                                                                   2      |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      1  3.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  M  M  M  +  M  +  +  +  +  M  M  +  M  +  +  M  +  M  M  +  M|  34        |
      Septum, Inflammation, Acute, Focal   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +              +     +  +  +  +        +     +  +     +            |  30        |
      Bilateral, Hyperplasia, Multifocal   |                                                                          |      1  2.0|
      Right, Hyperplasia, Focal            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Multifocal      |                                        2                 2               |      2  2.0|
      Inflammation, Chronic, Focal         |       2                                                                  |      1  2.0|
      Bilateral, Inflammation, Acute,      |                                                                          |            |
          Multifocal, Suppurative          |                4                                                         |      1  4.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 3                                                                        |      1  3.0|
      Cortex, Metaplasia, Focal, Osseous   |                         2                                                |      1  2.0|
      Cortex, Renal Tubule, Necrosis,      |                                                                          |            |
          Acute, Multifocal                |                                                                          |      1  2.0|
      Corticomedullary Junction,           |                                                                          |            |
          Metaplasia, Focal, Osseous       |                               1                                          |      1  1.0|
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization, Multifocal       |          2        2                                      2     2         |      4  2.0|
      Pelvis, Inflammation, Acute,         |                                                                          |            |
          Multifocal, Suppurative          |                   2                                                      |      1  2.0|
      Pelvis, Mineralization, Focal        |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Multifocal                      |                                           3                              |      1  3.0|
      Renal Tubule, Dilatation, Diffuse    |                                                          2              2|      2  2.0|
      Renal Tubule, Regeneration, Focal    |                                     1                                    |      4  1.3|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                  2                 2                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05052-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4|            |
                             DAY ON TEST   | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1|            |
                                           | 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Necrosis, Focal, Single      |                                                          1               |      1  1.0|
      Serosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
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