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TDMS Study 05052-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/08/94   
EXP: 05052                   2,4-DICHLOROPHENOL                TIME: 00:06:25   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C55345   
CONT: N01-ES-38068                                             CAS: 120-83-2    
PATHOLOGIST: S. EUSTIS                       G. DILL                            
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/08/94  
EXP: 05052                   2,4-DICHLOROPHENOL                TIME: 00:06:25  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C55345  
CONT: N01-ES-38068                                             CAS: 120-83-2   
PATHOLOGIST: S. EUSTIS                       G. DILL                           

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      28    107   561   575   577   590   605   651   660   678                 |
 |      682   682   687   689   700   717   718                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      105   138   395   469   476   482   510   547   610   651                 |
 |      657   665   668   673   681   687   717   724                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10000   PPM                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 4    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      171   265   274   315   375   392   394   413   483   537                 |
 |      589   600   660   668   675                                               |
 |  CENSORED DEATHS                                                               |
 |      416   416   416   416                                                     |
 |                                                                                |
 ==================================================================================

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |    98.0  96.0  96.0  96.0  96.0  96.0  96.0  86.0  82.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0  96.0  96.0  96.0  94.0  88.0  86.0  84.0  76.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10000   PPM|   100.0  98.0  96.0  92.0  84.0  81.8  79.6  75.2  72.9  68.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            5000 PPM         10000   PPM   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            64.0%            68.5%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.961          P=0.859          P=1.000       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       582.8            547.5            454.1         |
 |NATURAL DEATHS (C)      |       (48.8)           (43.2)           (41.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       678.0            662.4            620.2         |
 |(STANDARD ERROR)        |       (19.0)           (19.6)           (23.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      567   577   668   679   689                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      269   508   521   542   595   616   623   651   678   690                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10000   PPM                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      242   274   445   549   612   616   697                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  96.0  96.0  90.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0 100.0  98.0  98.0  98.0  98.0  92.0  90.0  84.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10000   PPM|   100.0 100.0  98.0  96.0  96.0  94.0  94.0  92.0  88.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            5000 PPM         10000   PPM   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       90.0%            80.0%            86.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.623          P=0.236          P=0.708       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.0            569.3            490.7         |
 |NATURAL DEATHS (C)      |       (26.4)           (38.8)           (66.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       718.8            696.3            694.8         |
 |(STANDARD ERROR)        |       ( 4.6)           (11.7)           (14.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         2,4-DICHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        5000 PPM         = 2
                                                        10000   PPM      = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1   1            2          3
      |
      |     1            21   2     3             3
      |                   1   2                   3 3                  2                         1
   95 +
      |                                             3     3            2          2              1 1
      |                                                   3        3              22
      |
P  90 +                                                            3  3            22              1  1
E     |
R     |                                                               33            2   2             1 1
C     |                                                                3 3              2      2        1     1
E  85 +
N     |                                                                  3          3          2         2    1  1
T     |                                                                                                  2    2  1 1
      |                                                                             3        3
S  80 +                                                                                      3        3       22   11
U     |
R     |                                                                                               33       2 2
V     |                                                                                                          22 11
I  75 +                                                                                                3         3
V     |                                                                                                           22
A     |                                                                                                          332211
L     |                                                                                                           33
   70 +                                                                                                             221  1
      |                                                                                                            3      3
      |                                                                                                              2   2
      |                                                                                                                  11
   65 +
      |                                                                                                                   2
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

                                                         2,4-DICHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        5000 PPM         = 2
                                                        10000   PPM      = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                      3   2                                             1
      |
      |
      |
   98 +                                        3   23                                   2        1 1
      |
      |
      |
   96 +                                             3                         3         2  2       1              1
      |
      |
      |
P  94 +                                                                       3            2  23                  11
E     |
R     |
C     |
E  92 +                                                                                       23      2  3         1 1
N     |
T     |
      |
S  90 +                                                                                               2  2           1    1
U     |
R     |
V     |
I  88 +                                                                                                  22           3
V     |
A     |
L     |
   86 +                                                                                                   2   2       3   3
      |
      |
      |
   84 +                                                                                                       2    2
      |
      |
      |
   82 +                                                                                                            2 2
      |
      |
      |
   80 +                                                                                                              2    2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

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