National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1807

TDMS Study 05052-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         2,4-DICHLOROPHENOL


NTP Experiment-Test: 05052-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 20:32:32




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-83-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14            3            8                                                  
    Dead                                               2            4            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           43           40                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (48)                      (49)                                                
   Intestine Small                                    (48)                      (49)                                                
      Muscularis, Jejunum, Leiomyoma                   1 (2%)                                                                       
   Liver                                              (50)         (23)         (50)                                                
      Neoplastic Nodule                                             1 (4%)                                                          
   Pancreas                                           (50)         (48)         (49)                                                
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (50)                      (50)                                                
   Stomach                                            (49)                      (50)                                                
   Tongue                                                          (1)                                                              
      Mucosa, Squamous Cell Papilloma                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (49)                                                
      Bilateral, Medulla, Pheochromocytoma Benign      1 (2%)                    1 (2%)                                             
      Cortex, Adenoma                                                            1 (2%)                                             
      Cortex, Carcinoma                                             1 (2%)                                                          
      Medulla, Pheochromocytoma Benign                 4 (8%)       3 (6%)       1 (2%)                                             
      Medulla, Pheochromocytoma Benign, Multiple                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (2)          (49)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (32)         (48)                                                
      Pars Distalis, Adenoma                          29 (58%)     24 (75%)     22 (46%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                    1 (2%)                                             
      Pars Distalis, Carcinoma                         2 (4%)       1 (3%)       5 (10%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)                      (49)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  8 (16%)                   6 (12%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                3 (6%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (38)         (2)          (40)                                                
      Adenoma                                          5 (13%)      2 (100%)     3 (8%)                                             
   Ovary                                              (50)         (5)          (49)                                                
   Uterus                                             (50)         (10)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Polyp Stromal                                   11 (22%)      6 (60%)     10 (20%)                                            
      Sarcoma                                                       1 (10%)                                                         
      Bilateral, Polyp Stromal                         1 (2%)                    1 (2%)                                             
      Cervix, Sarcoma Stromal                          1 (2%)                                                                       
      Endometrium, Deciduoma NOS                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (12)                      (8)                                                 
   Bone Marrow                                        (50)                      (49)                                                
   Lymph Node                                         (48)         (47)         (50)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
   Spleen                                             (50)         (48)         (50)                                                
   Thymus                                             (39)                      (47)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (9)          (46)                                                
      Adenocarcinoma                                   1 (2%)       1 (11%)                                                         
      Fibroadenoma                                     8 (17%)      7 (78%)      3 (7%)                                             
      Fibroadenoma, Multiple                           1 (2%)       1 (11%)      1 (2%)                                             
   Skin                                               (50)         (2)          (50)                                                
      Basosquamous Tumor Benign                                                  1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Trichoepithelioma                                                          1 (2%)                                             
      Subcutaneous Tissue, Carcinoma                                             1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (50%)      2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Thoracic, Subcutaneous Tissue, Lipoma                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)                      (50)                                                
      Lumbar, Osteosarcoma                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (48)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                    2 (4%)                                             
      Cerebrum, Granular Cell Tumor Benign                                       1 (2%)                                             
      Media, Astrocytoma Malignant                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (1)          (50)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (1)          (49)                                                
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (50)         (1)          (48)                                                
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            11 (22%)      7 (14%)     11 (22%)                                            
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          36          44                                                   
     Total Primary Neoplasms                           95          58          83                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          33          37                                                   
     Total Benign Neoplasms                            75          46          61                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          12          20                                                   
     Total Malignant Neoplasms                         19          12          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       4                                                   
     Total Metastatic Neoplasm                          2                       6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           16           12                                                  
    Dead                                               5            9            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           25           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (47)         (1)          (47)                                                
   Intestine Small                                    (47)         (1)          (47)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
      Jejunum, Sarcoma                                 1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
      Hepatocellular Carcinoma                         3 (6%)       1 (2%)                                                          
      Neoplastic Nodule                                3 (6%)                    1 (2%)                                             
      Neoplastic Nodule, Multiple                      1 (2%)                                                                       
   Mesentery                                          (3)          (2)          (2)                                                 
      Adenocarcinoma, Metastatic, Kidney               1 (33%)                                                                      
   Pancreas                                           (49)                      (49)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
      Acinus, Adenoma                                  1 (2%)                    1 (2%)                                             
   Pharynx                                                         (1)                                                              
      Palate, Squamous Cell Papilloma                               1 (100%)                                                        
   Salivary Glands                                    (50)                      (50)                                                
   Stomach                                            (49)         (2)          (49)                                                
      Forestomach, Squamous Cell Papilloma             1 (2%)                    2 (4%)                                             
   Tongue                                                                       (1)                                                 
      Mucosa, Squamous Cell Papilloma                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (2)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (3)          (50)                                                
      Bilateral, Medulla, Pheochromocytoma Complex     1 (2%)                                                                       
      Bilateral, Medulla, Pheochromocytoma Benign      9 (18%)      2 (67%)      6 (12%)                                            
      Cortex, Adenoma                                  1 (2%)                                                                       
      Medulla, Pheochromocytoma Benign                12 (24%)                  12 (24%)                                            
   Islets, Pancreatic                                 (49)                      (49)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Mixed Tumor Malignant                            1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (1)          (44)                                                
      Adenoma                                          1 (2%)       1 (100%)     1 (2%)                                             
   Pituitary Gland                                    (49)         (44)         (49)                                                
      Pars Distalis, Adenoma                           6 (12%)     10 (23%)      8 (16%)                                            
      Pars Intermedia, Carcinoma                                                 1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (50)                                                
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      C-Cell, Adenoma                                 11 (22%)      7 (14%)      5 (10%)                                            
      C-Cell, Adenoma, Multiple                                     1 (2%)                                                          
      Follicle, Adenoma, Cystic                                     2 (4%)                                                          
      Follicle, Adenoma, Cystic, Papillary                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (1)          (1)                                                 
      Adenocarcinoma, Metastatic, Kidney               1 (50%)                                                                      
      Chemodectoma Benign                                                        1 (100%)                                           
      Chemodectoma Malignant                           1 (50%)                                                                      
      Organ Of Zuckerkandl                             1 (50%)                                                                      
      Abdominal, Liposarcoma                                        1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (1)          (50)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
   Preputial Gland                                    (43)         (3)          (47)                                                
      Adenoma                                          2 (5%)       2 (67%)      7 (15%)                                            
      Carcinoma                                                     1 (33%)                                                         
   Prostate                                           (48)         (3)          (50)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
   Testes                                             (50)         (38)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           35 (70%)     25 (66%)     37 (74%)                                            
      Interstitial Cell, Adenoma                      13 (26%)     12 (32%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (26)                      (16)                                                
   Bone Marrow                                        (49)                      (50)                                                
   Lymph Node                                         (50)         (9)          (50)                                                
      Carcinoma, Metastatic, Skin                      1 (2%)                                                                       
   Spleen                                             (50)         (14)         (50)                                                
   Thymus                                             (39)         (1)          (43)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (25)         (4)          (22)                                                
      Adenocarcinoma                                   1 (4%)       1 (25%)                                                         
      Fibroadenoma                                     1 (4%)       3 (75%)                                                         
   Skin                                               (49)         (12)         (50)                                                
      Basal Cell Adenoma                                            1 (8%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Fibrosarcoma                                                  1 (8%)                                                          
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma                                                    2 (4%)                                             
      Squamous Cell Papilloma                          2 (4%)       1 (8%)       1 (2%)                                             
      Trichoepithelioma                                             1 (8%)       1 (2%)                                             
      Sebaceous Gland, Adenocarcinoma                               1 (8%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       2 (17%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             2 (17%)      2 (4%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma NOS                           1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (1)          (50)                                                
      Carcinoma, Metastatic, Skin                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (3)          (50)                                                
      Adenocarcinoma, Metastatic, Kidney               1 (2%)                                                                       
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (33%)                                                         
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Skin                      1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Liposarcoma, Metastatic, Tissue NOS                           1 (33%)                                                         
      Sarcoma, Metastatic                              1 (2%)                                                                       
      Mediastinum, Lipoma                              1 (2%)                                                                       
   Nose                                               (45)         (48)         (46)                                                
      Turbinate, Respiratory Epithelium,                                                                                            
          Adenocarcinoma                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (43)                      (36)                                                
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)                                                                     
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (8)          (49)                                                
      Mixed Tumor Malignant                                         1 (13%)                                                         
      Renal Tubule, Adenocarcinoma                     2 (4%)                                                                       
   Urinary Bladder                                    (48)         (2)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            31 (62%)     17 (34%)     17 (34%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05052-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 20:32:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        5000 PPM     10000                                                  
                                                                             PPM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          48                                                   
     Total Primary Neoplasms                          152         102         119                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          43          47                                                   
     Total Benign Neoplasms                           106          73          97                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          25          21                                                   
     Total Malignant Neoplasms                         45          28          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2                                                               
     Total Metastatic Neoplasm                         12           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                                                               
     Total Uncertain Neoplasms                          1           1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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