National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1811

TDMS Study 05052-01 Pathology Tables

NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 11:10:02




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  120-83-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rectum, Parasite Metazoan            |                                  2                                       |             
      Rectum, Parasite Metazoan, Multifocal|          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                                                                        |             
      Basophilic Focus, Multiple           | X  X  X  X  X     X     X  X     X           X  X  X        X  X  X     X|             
      Basophilic Focus, Single             |                                           X                              |             
      Clear Cell Focus, Single             |                                        X                                 |             
      Hemorrhage, Acute, Multifocal        |                                        3                                 |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |    2     2  2     2  2           2  2  2     2  2              2        4|             
      Bile Duct, Hyperplasia, Multifocal   | 2  2     2     3                                                     3   |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                   2                                                      |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                                        2           3                     |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |             1        3                 2           2     3           4   |             
      Periportal, Hematopoietic Cell       |                                                                          |             
          Proliferation, Multifocal        |                                                 2                       3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |    1           2                                                  3      |             
      Acinus, Atrophy, Multifocal          |          2              2  2  2  1           3  2  2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glandular, Ulcer, Acute, Multifocal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Degeneration, Chronic,   |                                                                          |             
           Multifocal                      | 2  1  2  2  1     3     1  1  2  3  2  2  2  2  2  1  2     1     2     3|             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Cortex, Congestion,       |                                                                          |             
          Multifocal                       |                               3                                          |             
      Bilateral, Cortex, Congestion,       |                                                                          |             
          Multifocal, Subacute             |                3                                                         |             
      Bilateral, Cortex, Hyperplasia, Focal|                                                             2            |             
      Bilateral, Cortex, Hyperplasia,      |                                                                          |             
          Multifocal                       |       2                                                                  |             
      Bilateral, Medulla, Hyperplasia,     |                                                                          |             
           Multifocal                      |                                                                         3|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Cytoplasmic Alteration, Focal|             2                                   2                        |             
      Cortex, Degeneration, Cystic, Focal  |                                                                2         |             
      Cortex, Degeneration, Fatty, Focal   |    2  2           3     3        2              2                    3   |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Cortex, Hyperplasia, Focal           |                   2           2                       2                  |             
      Cortex, Hyperplasia, Multifocal      |             2                    2                                       |             
      Cortex, Hypertrophy, Focal           |       3                                                                  |             
      Cortex, Karyomegaly, Focal           |                                                                          |             
      Cortex, Necrosis, Multifocal         |                                                    2                     |             
      Medulla, Hyperplasia, Focal          |                                                                      2   |             
      Medulla, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +           +     +        +     +  +           +        +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +        +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Hyperplasia, Multifocal              |                                                                         2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |          X              X                                X        X  X  X|             
      Pars Distalis, Cyst, Single          |                X                                                         |             
      Pars Distalis, Hemorrhage, Focal     |                         3                                                |             
      Pars Distalis, Hemorrhage, Multifocal|                                                                3         |             
      Pars Distalis, Hyperplasia, Focal    |       2                       3                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |          2                                                        2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Multifocal      | 2  2  2  2     2  1  2  3  2        2  2  2  2           2  2  2  2      |             
      Follicle, Cyst, Single               |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Cyst, Multiple                       |             X  X                                                         |             
      Inflammation, Chronic Active, Focal  |                                                             2            |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                      2   |             
      Inflammation, Multifocal, Subacute   |                   2                                                      |             
      Necrosis, Acute, Focal               |                                                                          |             
      Necrosis, Chronic Active, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |             
      Bilateral, Follicle, Cyst            |                                                                          |             
      Follicle, Cyst, Multiple             |                            X                                             |             
      Follicle, Cyst, Single               |                   X                                                     X|             
      Germinal Epithelium, Mineralization, |                                                                          |             
           Multifocal                      |                                                                          |             
      Left, Follicle, Cyst                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                     X                                    |             
      Periovarian Tissue, Right, Cyst      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Cervix, Diverticulum                 |                                                 X                        |             
      Cervix, Inflammation, Multifocal,    |                                                                          |             
           Suppurative                     |                                                 3                        |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 2                 3                 2  2  2     2  3     2     2  2     2|             
      Lumen, Ectasia, Multifocal           |                            4                                             |             
      Lumen, Right, Ectasia, Focal         |                                                                          |             
      Lumen, Right, Ectasia, Multifocal    |                                                                          |             
      Serosa, Inflammation, Chronic, Focal |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +              +                    +     +           +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal, Neutrophil  |                                                                          |             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |       2     2                                2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mandibular, Hemorrhage, Multifocal   | 3     2                                      3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |    2                             3              3                        |             
      Mandibular, Hyperplasia, Multifocal, |                                                                          |             
           Plasma Cell                     |                                     3     3                 3  3         |             
      Mandibular, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        |             2                                                           2|             
      Mediastinal, Depletion Lymphoid,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinal, Hemorrhage, Multifocal  |                   3              3              3           3            |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous, Multifocal        |             3           3           2                                   2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |                                                                          |             
      Lymphoid Follicle, Inflammation,     |                                                                          |             
           Granulomatous, Multifocal       |       2                                                                  |             
      Red Pulp, Congestion, Focal          |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multifocal        |          2           3  2        2              2     3     2  2  2     3|             
      Red Pulp, Necrosis, Acute, Focal     |                                                          3               |             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +|             
      Depletion Lymphoid, Multifocal       | 3  2  3  2  2     2  3     2  3           2        3  2  3  2           3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia, Cystic,         |                                                                          |             
          Multifocal                       |    3  3     3                       3  3  3        3  3  3  3  3  2  2  2|             
      Acinus, Hyperplasia, Cystic, Multiple|                            3                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Subcutaneous Tissue,       |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Multifocal                      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis, Multifocal     | 3           2                       3                    3               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage, Acute, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cerebrum, Compression, Focal         |                                     3     4                    3         |             
      Medulla, Hemorrhage, Multifocal      |                                                    2                     |             
      Ventricle, Hydrocephalus, Multifocal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute, Multifocal        |                                                                          |             
      Hemorrhage, Acute, Multifocal        |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                          3               |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                            2     2                                      2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal, Subacute            |    2        2  2  3                                         2  2  3  3   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Multifocal                      | 3  2     2  2                       2        2        2           3     2|             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Congestion, Acute, Multifocal   |                            3                                             |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         | 2           2  2        2     1  2     2     2  2                 2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                      +                 +           +   |             
      Hemorrhage, Acute, Multifocal        | 3                                                                        |             
      Lens, Cataract, Multifocal           |                                        2                                 |             
      Retina, Atrophy, Multifocal          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Multifocal, Subacute   | 2  2  2     2  2  2     2        2                    2              2  3|             
      Bilateral, Inflammation, Multifocal, |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Nephropathy, Chronic,     |                                                                          |             
           Multifocal                      | 2  1  1  2  3  2  1  2  3  3     3  3  4  4  1  2  3  3  1  2  2  1  1  3|             
      Cortex, Casts, Single                |                                                                          |             
      Cortex, Inflammation, Chronic, Focal |    3                                                                     |             
      Medulla, Left, Cyst, Multiple        |                               X                                          |             
      Renal Tubule, Degeneration, Acute,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|             
                                           | 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|  48        |
      Rectum, Parasite Metazoan            |                            2                                             |      2  2.0|
      Rectum, Parasite Metazoan, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +     +  +  +  +  +     +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +     +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +     +  +  +  +     +     +  +  +  +  +     +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +     +     +  +  +  +  +     +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +        +  +  +  +  +  +  +     +     +  +  +  +  +     +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +     +     +  +     +  +  +  +     +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus, Multiple           |    X     X  X  X     X  X  X        X     X  X  X     X  X  X  X  X  X   |     33     |
      Basophilic Focus, Single             | X                                                                        |      2     |
      Clear Cell Focus, Single             |                            X                                             |      2     |
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 2  2     3              2  2        2     2  2  3     3     3  3     2  4|     26  2.3|
      Bile Duct, Hyperplasia, Multifocal   |                                        3        2        2               |      8  2.4|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                                                 2                        |      3  2.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                               4        3                                4|      9  2.9|
      Periportal, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                  +   |   2        |
      Inflammation, Chronic, Multifocal    |                   2                                                      |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |                                                                2        2|      5  2.0|
      Acinus, Atrophy, Multifocal          | 2           2                                      2  3  3        3  2   |     15  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Glandular, Ulcer, Acute, Multifocal  |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Degeneration, Chronic,   |                                                                          |            |
           Multifocal                      | 1  2  1     2     2  2  2  3  2     2     2  3  2     2  2  2  2  2  3  2|     40  2.0|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Multifocal                      |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Cortex, Congestion,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Bilateral, Cortex, Congestion,       |                                                                          |            |
          Multifocal, Subacute             |                                                                          |      1  3.0|
      Bilateral, Cortex, Hyperplasia, Focal|                                                                          |      1  2.0|
      Bilateral, Cortex, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Bilateral, Medulla, Hyperplasia,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Cortex, Cyst                         | X                                                                        |      1     |
      Cortex, Cytoplasmic Alteration, Focal|                                              3                           |      3  2.3|
      Cortex, Degeneration, Cystic, Focal  |                                                                          |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |    2     2                 2  2                                      2   |     12  2.3|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                  2        2                              |      2  2.0|
      Cortex, Hyperplasia, Focal           |                         2           2           2        2     2         |      8  2.0|
      Cortex, Hyperplasia, Multifocal      |                                                                          |      2  2.0|
      Cortex, Hypertrophy, Focal           |                                                          3               |      2  3.0|
      Cortex, Karyomegaly, Focal           |                                           2                 2     2      |      3  2.0|
      Cortex, Necrosis, Multifocal         |                                                                          |      1  2.0|
      Medulla, Hyperplasia, Focal          |                               2                                          |      2  2.0|
      Medulla, Hyperplasia, Multifocal     |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +     +  +  +  +                 +           +  +                 +|  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +     +           +  +     +     +  +     +  +  +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  M  M  M  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  M  +  +|  36        |
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                         X                                                |      1     |
      Pars Distalis, Cyst, Multiple        | X                                X  X           X        X        X      |     12     |
      Pars Distalis, Cyst, Single          |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hemorrhage, Focal     |                                                                          |      1  3.0|
      Pars Distalis, Hemorrhage, Multifocal|                                                                3  3  3   |      4  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                     2           3           3            |      5  2.6|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Multifocal      |       2  2  2     2  2  2  2  2     2     2     2           2           2|     30  2.0|
      Follicle, Cyst, Single               |                                                          X               |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  M  +  +  +  M  +  +     M  +  +  +  +  M  +  M  +  +  +  M  +  M  +|  38        |
      Cyst, Multiple                       |                                                                          |      2     |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Necrosis, Acute, Focal               |                2                                                         |      1  2.0|
      Necrosis, Chronic Active, Focal      |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Periovarian Tissue, Cyst  |    X                                                                     |      1     |
      Bilateral, Follicle, Cyst            |                                                       X                  |      1     |
      Follicle, Cyst, Multiple             |                                                                          |      1     |
      Follicle, Cyst, Single               |                                                                          |      2     |
      Germinal Epithelium, Mineralization, |                                                                          |            |
           Multifocal                      |                                           2                              |      1  2.0|
      Left, Follicle, Cyst                 |                X                                                         |      1     |
      Periovarian Tissue, Cyst             |                                                                          |      1     |
      Periovarian Tissue, Right, Cyst      |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |          3                                                               |      2  3.5|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       | 3                                                                        |      1  3.0|
      Cervix, Diverticulum                 |          X                                                               |      2     |
      Cervix, Inflammation, Multifocal,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Glandular, Multifocal           |    2     2  2  2           2  1     2     2        2        2  2  2     2|     24  2.0|
      Lumen, Ectasia, Multifocal           | 3        3                                                               |      3  3.3|
      Lumen, Right, Ectasia, Focal         |                         3                                                |      1  3.0|
      Lumen, Right, Ectasia, Multifocal    |                                                                      3   |      1  3.0|
      Serosa, Inflammation, Chronic, Focal |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +                       +  +     +        +                        |  12        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Multifocal, Neutrophil  | 3                                                                        |      1  3.0|
      Hyperplasia, Multifocal, Reticulum   |                                                                          |            |
          Cell                             |                3                    3                                    |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           | X                                                                        |      1     |
      Mandibular, Hemorrhage, Multifocal   |                         2           2                    2  2  2     2   |      9  2.2|
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |          2     2                                                         |      5  2.4|
      Mandibular, Hyperplasia, Multifocal, |                                                                          |            |
           Plasma Cell                     |                                                                          |      4  3.0|
      Mandibular, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |                                                                   2     2|      4  2.0|
      Mediastinal, Depletion Lymphoid,     |                                                                          |            |
           Multifocal                      |                                              2                           |      1  2.0|
      Mediastinal, Hemorrhage, Multifocal  | 2                                                                    3   |      6  2.8|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous, Multifocal        |                                                          2              2|      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |                                              2                       2   |      2  2.0|
      Lymphoid Follicle, Inflammation,     |                                                                          |            |
           Granulomatous, Multifocal       |                                                             3            |      2  2.5|
      Red Pulp, Congestion, Focal          |                         2                                                |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multifocal        |             2  2     3  2  2        2     2        2  2  3  2  2  2  3  2|     25  2.2|
      Red Pulp, Necrosis, Acute, Focal     |                                                                          |      1  3.0|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |                   3                                                  3   |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  +  M  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  39        |
      Depletion Lymphoid, Multifocal       | 2  2     2     2              3     3     2        2  2  3  2  2  2  3  3|     30  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|  46        |
      Acinus, Hyperplasia, Cystic,         |                                                                          |            |
          Multifocal                       |             3  3  2  3        4     3  2  3           3  2           4  2|     26  2.8|
      Acinus, Hyperplasia, Cystic, Multiple|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Subcutaneous Tissue,       |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femur, Osteopetrosis, Multifocal     |                                        2        2                 2      |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage, Acute, Focal |                                  4                                       |      1  4.0|
      Cerebrum, Compression, Focal         |       3                                   3  3              2        3  3|      9  3.0|
      Medulla, Hemorrhage, Multifocal      |                                                                          |      1  2.0|
      Ventricle, Hydrocephalus, Multifocal |       3                                                              3  2|      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute, Multifocal        |                                              3                       3   |      2  3.0|
      Hemorrhage, Acute, Multifocal        |                                  2                                       |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Focal                           |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|  45        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Focal, Subacute                 |             2                                               2            |      5  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Multifocal, Subacute            |    2     3     2     3        2  2  2     3              2        3      |     18  2.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Multifocal                      |    2        2  2           2     3  2           3     2  2        2      |     19  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2|            |
                                           | 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Congestion, Acute, Multifocal   |                                                                          |      1  3.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         |    2  2        2        2           2     2           2  2  2  2        2|     21  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  3.0|
      Lens, Cataract, Multifocal           |                                                                          |      1  2.0|
      Retina, Atrophy, Multifocal          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +  +  +  M     +  +     +     +  +  +  M  +     +     +  +  +  +  +|  40        |
      Inflammation, Multifocal, Subacute   |    3                                2                          2  2      |     15  2.1|
      Bilateral, Inflammation, Multifocal, |                                                                          |            |
           Subacute                        |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Nephropathy, Chronic,     |                                                                          |            |
           Multifocal                      | 2  2  1  1  2  3  2  2  2  2  1  2  3  2  4     2     1  3     3  2  3  3|     46  2.2|
      Cortex, Casts, Single                |                                     X                                    |      1     |
      Cortex, Inflammation, Chronic, Focal |                                                                          |      1  3.0|
      Medulla, Left, Cyst, Multiple        |                                                                          |      1     |
      Renal Tubule, Degeneration, Acute,   |                                                                          |            |
           Multifocal                      |                                        4     3                           |      2  3.5|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic, Multifocal          |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +              +     +  +        +     +     +        +  +            |             
      Angiectasis, Multifocal              | 3                                                                        |             
      Basophilic Focus, Multiple           | X  X              X     X           X     X     X        X  X            |             
      Basophilic Focus, Single             |                                                                          |             
      Clear Cell Focus                     |                                                 X                        |             
      Cyst                                 |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       | 2                       2  2                             1  2            |             
      Inflammation, Multifocal, Subacute   |                                     2                                    |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                           3              2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 1     1  1              2                          2        1           2|             
      Acinus, Atrophy, Multifocal          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Cortex, Atrophy, Diffuse  |                                                                         3|             
      Bilateral, Cortex, Congestion,       |                                                                          |             
          Multifocal                       |                               3                                          |             
      Bilateral, Cortex, Degeneration,     |                                                                          |             
           Diffuse, Fatty                  |          4                                                               |             
      Bilateral, Cortex, Degeneration,     |                                                                          |             
           Fatty, Multifocal               |                                                       2                  |             
      Bilateral, Cortex, Hyperplasia,      |                                                                          |             
          Multifocal                       | 2                          2                    2        3               |             
      Capsule, Hyperplasia, Focal          |                                                             2            |             
      Cortex, Cytoplasmic Alteration, Focal|                                           2     2                        |             
      Cortex, Cytoplasmic Alteration,      |                                                                          |             
          Multifocal                       |                      2                                                   |             
      Cortex, Degeneration, Cystic, Focal  |                                                                          |             
      Cortex, Degeneration, Fatty, Focal   | 2              2        3  3                                2            |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Cortex, Hyperplasia, Focal           |    2                 2           4                          2            |             
      Cortex, Hyperplasia, Multifocal      |                2                                                         |             
      Cortex, Karyomegaly, Focal           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Right, Atrophy, Multifocal   |                                     3                                    |             
      Medulla, Cyst                        |                                                                          |             
      Medulla, Karyomegaly, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +     +                    +     +     +           +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +        +  +           +  +        +  +  +  +  +  +  +     +  +|             
      Cyst, Multiple                       |                                                 X                        |             
      Pars Distalis, Cyst                  |                                     X                 X     X            |             
      Pars Distalis, Cyst, Multiple        |    X     X                                                               |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                     3                                    |             
      Pars Distalis, Necrosis, Chronic,    |                                                                          |             
           Multifocal                      |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                     +                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                  +                                   +   |             
      Necrosis, Coagulative, Multifocal    |                                                                      4   |             
      Periovarian Tissue, Cyst             |                                  X                                       |             
      Periovarian Tissue, Right, Cyst      |                                                                          |             
      Periovarian Tissue, Left, Cyst       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +                    +                 +           +        +         |             
      Bilateral, Lumen, Ectasia            |                         3                                                |             
      Cervix, Diverticulum                 |                                           X                              |             
      Cervix, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Cervix, Prolapse, Multifocal         |                                                                          |             
      Endometrium, Hemorrhage, Multifocal  |    3                                                                     |             
      Lumen, Hemorrhage, Focal, Subacute   |                                                       4        4         |             
      Lumen, Right, Ectasia, Focal         |                                                       4                  |             
      Lumen, Right, Ectasia, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                          3               |             
      Cortex, Mandibular, Cyst, Multiple   |                                                                          |             
      Mandibular, Hemorrhage, Multifocal   |                            2                                             |             
      Mandibular, Hyperplasia, Multifocal, |                                                                          |             
           Plasma Cell                     |                                  2                                   3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Mandibular, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        |                2                          2        3                     |             
      Mandibular, Pigmentation,            |                                                                          |             
          Hemosiderin, Multifocal          |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |          3                                                           3   |             
      Red Pulp, Congestion, Focal          |                                                    3                     |             
      Red Pulp, Fibrosis, Focal            |                                                    3                     |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multifocal        | 2  3              3        3     2  3                    2  2            |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multiple          |                               2                                          |             
      Red Pulp, Inflammation, Chronic      |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Red Pulp, Inflammation,              |                                                                          |             
          Granulomatous, Multifocal        |                                                                          |             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |                3              2              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                                                                    +   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                                                                     |             
      Hindlimb, Subcutaneous Tissue,       |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Granulomatous                   |                                                                          |             
      Hindlimb, Epidermis, Acanthosis,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Hindlimb, Epidermis, Hyperkeratosis, |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                              +                           |             
      Congestion, Acute, Diffuse           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Cortex, Left, Cyst, Single           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +                                          |             
      Lumen, Calculus Gross Observation    |                               X                                          |             
      Mucosa, Hyperplasia, Chronic,        |                                                                          |             
          Multifocal                       |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +     +     +  +  +     +        +           +  +  +     +  +   |  23        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Basophilic Focus, Multiple           | X                    X  X                             X  X               |     14     |
      Basophilic Focus, Single             |                                  X                                   X   |      2     |
      Clear Cell Focus                     |                                                                   X      |      2     |
      Cyst                                 |                      X                                                   |      1     |
      Inflammation, Focal, Granulomatous   | 2                          2                                             |      2  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                         2                             2                  |      7  1.9|
      Inflammation, Multifocal, Subacute   |                                           2                              |      2  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                3                                                  2      |      2  2.5|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |                            3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                M                                                         |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy, Focal               |       1                    2                          1                  |     10  1.4|
      Acinus, Atrophy, Multifocal          |    2           2     1        1        2                             2  2|      8  1.8|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Bilateral, Cortex, Atrophy, Diffuse  |                                                                          |      1  3.0|
      Bilateral, Cortex, Congestion,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Bilateral, Cortex, Degeneration,     |                                                                          |            |
           Diffuse, Fatty                  |                                                                          |      1  4.0|
      Bilateral, Cortex, Degeneration,     |                                                                          |            |
           Fatty, Multifocal               |          3                                                           2   |      3  2.3|
      Bilateral, Cortex, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                             2  2     2   |      7  2.1|
      Capsule, Hyperplasia, Focal          |                                                                          |      1  2.0|
      Cortex, Cytoplasmic Alteration, Focal|                            2                                             |      3  2.0|
      Cortex, Cytoplasmic Alteration,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Cortex, Degeneration, Cystic, Focal  |       2                                                                  |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |             2                                2                           |      7  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Focal           |                   2                                                     3|      6  2.5|
      Cortex, Hyperplasia, Multifocal      |                                                       2  2               |      3  2.0|
      Cortex, Karyomegaly, Focal           |                                        3                                 |      2  2.5|
      Cortex, Right, Atrophy, Multifocal   |                                                                          |      1  3.0|
      Medulla, Cyst                        | X                                                                        |      1     |
      Medulla, Karyomegaly, Focal          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +                 +  +     +  +        +  +  +                 +      |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +     +  +  +  +  +  +     +  +  +  +     +  +        +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                  +                                      +|   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +  +        +     +  +  +     +        +  +  +  +     +|  32        |
      Cyst, Multiple                       |                                                                          |      1     |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Cyst, Multiple        |             X                 X                          X  X  X         |      7     |
      Pars Distalis, Hemorrhage, Focal     |                3                                                         |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  3.0|
      Pars Distalis, Necrosis, Chronic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                         +|   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +                       +                                +   |   5        |
      Necrosis, Coagulative, Multifocal    |                                                                          |      1  4.0|
      Periovarian Tissue, Cyst             |                                                                          |      1     |
      Periovarian Tissue, Right, Cyst      |             X                                                            |      1     |
      Periovarian Tissue, Left, Cyst       |                                     X                                X   |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +     +                       +           +                     |  10        |
      Bilateral, Lumen, Ectasia            |                                                                          |      1  3.0|
      Cervix, Diverticulum                 |                                                                          |      1     |
      Cervix, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |       4                                                                  |      1  4.0|
      Cervix, Prolapse, Multifocal         |       3                                                                  |      1  3.0|
      Endometrium, Hemorrhage, Multifocal  |                                                                          |      1  3.0|
      Lumen, Hemorrhage, Focal, Subacute   |                                                                          |      2  4.0|
      Lumen, Right, Ectasia, Focal         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Right, Ectasia, Multifocal    |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Cortex, Mandibular, Cyst, Multiple   |                                                 X                        |      1     |
      Mandibular, Hemorrhage, Multifocal   |                                           1  2           2              1|      5  1.6|
      Mandibular, Hyperplasia, Multifocal, |                                                                          |            |
           Plasma Cell                     |       3                          2        2  2                          3|      8  2.5|
      Mandibular, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                  2                                       |      1  2.0|
      Mandibular, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |                               2        2  2           3                  |      7  2.3|
      Mandibular, Pigmentation,            |                                                                          |            |
          Hemosiderin, Multifocal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      2  3.0|
      Red Pulp, Congestion, Focal          |                                                                          |      1  3.0|
      Red Pulp, Fibrosis, Focal            |                                                                          |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multifocal        | 2                       2        2        2     2     3        3  2     3|     17  2.4|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multiple          |                                                                          |      1  2.0|
      Red Pulp, Inflammation, Chronic      |                                                                          |            |
          Active, Multifocal               |                                                             3            |      1  3.0|
      Red Pulp, Inflammation,              |                                                                          |            |
          Granulomatous, Multifocal        |                                     4                                    |      1  4.0|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                       +  +     +                 +        +        +|   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                 +                        |   2        |
      Hindlimb, Subcutaneous Tissue,       |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Granulomatous                   |                                                 3                        |      1  3.0|
      Hindlimb, Epidermis, Acanthosis,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Multifocal                      |                                                 3                        |      1  3.0|
      Hindlimb, Epidermis, Hyperkeratosis, |                                                                          |            |
           Multifocal                      |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   1        |
      Congestion, Acute, Diffuse           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                A                                      +                  |   1        |
      Lens, Cataract                       |                                                       4                  |      1  4.0|
      Retina, Atrophy, Multifocal          |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                           +                              |   1        |
      Cortex, Left, Cyst, Single           |                                           X                              |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
      Lumen, Calculus Gross Observation    |                                                                          |      1     |
      Mucosa, Hyperplasia, Chronic,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Parasite Metazoan, Single     |                                              2                           |             
      Rectum, Parasite Metazoan, Single    |          2        X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid, Multifocal            |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                  2                                       |             
      Basophilic Focus, Multiple           | X  X  X  X  X  X  X  X  X  X  X     X  X        X     X     X  X  X     X|             
      Basophilic Focus, Single             |                                                                      X   |             
      Clear Cell Focus, Multiple           |                                                       X                  |             
      Clear Cell Focus, Single             |                   X                                                      |             
      Hyperplasia, Focal                   |                                              3                           |             
      Inflammation, Focal,                 |                                                                          |             
          Membranoproliferative            |                                                                      1   |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       | 3  3  2     2  2        3           2  3              3        2  2      |             
      Bile Duct, Hyperplasia, Multifocal   |          2                       3  2                    3               |             
      Centrilobular, Pigmentation,         |                                                                          |             
          Hemosiderin, Multifocal          |                            3                                             |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                                                    1                     |             
      Hepatocyte, Necrosis, Multifocal     |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |                               3                       4                  |             
      Hepatocyte, Centrilobular, Necrosis, |                                                                          |             
           Multifocal, Subacute            |                                                 4                        |             
      Left Lateral Lobe, Angiectasis, Focal|                                                                          |             
      Median Lobe, Atrophy, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Periportal, Infiltration Cellular,   |                                                                          |             
           Acute, Multifocal, Lymphocyte   |                                                                          |             
      Sinusoid, Subserosa, Congestion,     |                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Acinus, Atrophy, Focal               |          2                                                              3|             
      Acinus, Atrophy, Multifocal          |    2                 2                                   4               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperkeratosis,         |                                                                          |             
          Multifocal                       |                            3                                             |             
      Forestomach, Hyperplasia, Multifocal,|                                                                          |             
           Squamous                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Thrombosis, Multifocal, |                                                                          |             
           Subacute                        |                                                 X                        |             
      Myocardium, Degeneration, Chronic,   |                                                                          |             
           Multifocal                      | 2     2  3  2  2     2        3     2  2     3  3  2  2     2  2     1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Bilateral, Cortex, Degeneration,     |                                                                          |             
           Fatty, Multifocal               |                                                 2                        |             
      Bilateral, Cortex, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                                             2            |             
      Bilateral, Medulla, Hyperplasia,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Medulla, Infiltration     |                                                                          |             
          Cellular, Acute, Multifocal,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Cortex, Cytoplasmic Alteration, Focal|          2                                                               |             
      Cortex, Degeneration, Fatty, Focal   |    2                       2                                            2|             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                                          2               |             
      Cortex, Hyperplasia, Focal           |    2           3     2              3                             2  3  2|             
      Cortex, Hyperplasia, Multifocal      |                               2                                          |             
      Cortex, Hypertrophy, Focal           |                                                                          |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
      Medulla, Hyperplasia, Multifocal     |          2                                                  2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +     +              +     +  +  +     +           +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +     +  +     +  +  +  +     +           +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  A  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Hyperplasia, Glandular, Multifocal   |                2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         X     X                                          |             
      Pars Distalis, Cyst, Multiple        |                                  X              X     X                  |             
      Pars Distalis, Cyst, Single          |                                                                      X   |             
      Pars Distalis, Hemorrhage, Multifocal|                3     3                                                   |             
      Pars Distalis, Hemorrhage,           |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse  |                                                             3            |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |             2                                3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           | 3                                                                        |             
      C-Cell, Hyperplasia, Multifocal      |    2     2  2     2     2     2              2              2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Glandular        |                                        2                                 |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Cyst, Multiple             |       X        X  X                                                      |             
      Periovarian Tissue, Cyst             |                                        X                                 |             
      Periovarian Tissue, Left, Cyst       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Lumen, Ectasia, Multifocal| 3                                                                        |             
      Cervix, Diverticulum                 |                                                                          |             
      Cervix, Fibrosis, Chronic, Multifocal|                                                                          |             
      Cervix, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 2     2  2        2  1     2  2     2     2  3     2        1     2  2  2|             
      Lumen, Ectasia, Focal                |                                     2                                    |             
      Lumen, Ectasia, Multifocal           |             3                 3                                         3|             
      Lumen, Right, Ectasia, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lumen, Left, Ectasia, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                          +     +     +               |             
      Neutrophilia                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal, Neutrophil  |          2                                         4                     |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Myelofibrosis, Multifocal            |                                                    3                     |             
      Erythroid Cell, Hypoplasia,          |                                                                          |             
          Multifocal                       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Angiectasis, Multifocal  |                                                                          |             
      Mandibular, Depletion Lymphoid,      |                                                                          |             
          Multifocal                       |                            3                                             |             
      Mandibular, Hemorrhage, Multifocal   |    2  2        3  2  3        3     3  2              2           2  3   |             
      Mandibular, Hyperplasia, Histiocytic,|                                                                          |             
           Multifocal                      |                   3                                                      |             
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                                                             2            |             
      Mandibular, Hyperplasia, Multifocal, |                                                                          |             
           Plasma Cell                     |                                                                3         |             
      Mandibular, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Mandibular, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        | 2           2           4                                                |             
      Mandibular, Pigmentation,            |                                                                          |             
          Hemosiderin, Multifocal          |                                                                          |             
      Mediastinal, Hemorrhage, Multifocal  |                            4                                             |             
      Mediastinal, Inflammation, Chronic,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous, Multifocal        | 2              2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |                            4                                             |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multifocal        | 2  2  2     2           2     3     2  3  2     2  4  3     3  2  2  3  2|             
      Red Pulp, Inflammation,              |                                                                          |             
          Granulomatous, Multifocal        |                                                                          |             
      Red Pulp, Necrosis, Acute, Multifocal|                                                                          |             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |                3           3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Multifocal       | 3  2  2  3  3  3  2  2           2     3     3  2           2  3  2  2  2|             
      Pigmentation, Hemosiderin, Multifocal|                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia, Cystic,         |                                                                          |             
          Multifocal                       | 3  3  2        3     2           2  2  2        3              2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Ulcer, Acute, Focal       |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis, Multifocal     |                                     3                             3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cerebellum, Hemorrhage, Multifocal   |                                                                          |             
      Cerebrum, Compression, Focal         |                3                       3                                 |             
      Cerebrum, Hemorrhage, Focal          |                                                                          |             
      Cerebrum, Perivascular Cuffing, Focal|                                                                          |             
      Medulla, Hemorrhage, Focal           |                                  3                                       |             
      Ventricle, Hydrocephalus, Multifocal |                2                       2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                3                                      4                  |             
      Bronchiole, Epithelium, Hyperplasia, |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                            2                                             |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |       1                                                                  |             
      Interstitium, Inflammation,          |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                2              3                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal, Subacute            |    3  3                          3                                       |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Multifocal                      |    2  2  2  2  1  2     2     2              2                       2   |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         | 2  2     2        3  2  2        2                          2  2  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Wall, Hemorrhage, Multifocal         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                       +                             +         |             
      Lens, Cataract                       |          3                                                     4         |             
      Retina, Atrophy, Multifocal          |          4                                                     4         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +     +     +  +     +  +     +  +     +  +  +   |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Inflammation, Multifocal, Subacute   |       2                 2              2                       2         |             
      Bilateral, Inflammation, Multifocal, |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Nephropathy, Chronic,     |                                                                          |             
           Multifocal                      | 2  1  3  2  2  2                    1  2     1  1     2  3  2  1  2      |             
      Bilateral, Nephropathy, Multifocal   |                               1                                          |             
      Cortex, Infarct, Focal               |                                                                          |             
      Cortex, Inflammation, Chronic, Focal |                                                                          |             
      Cortex, Left, Cyst, Single           |                                                                      X   |             
      Renal Tubule, Degeneration, Acute,   |                                                                          |             
           Multifocal                      |                                  3                                       |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Mucosa, Hyperplasia, Multifocal      |                                                                          |             
      Mucosa, Hyperplasia, Multifocal,     |                                                                          |             
           Squamous                        |                                                          4               |             
      Mucosa, Metaplasia, Multifocal,      |                                                                          |             
          Squamous                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Colon, Parasite Metazoan, Single     |                                                                          |      1  2.0|
      Rectum, Parasite Metazoan, Single    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ileum, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Basophilic Focus, Multiple           | X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X|     42     |
      Basophilic Focus, Single             |                                                                          |      1     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Clear Cell Focus, Single             |                            X        X                                    |      3     |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Focal,                 |                                                                          |            |
          Membranoproliferative            |                                                                          |      1  1.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 2  2     3     2     2  2  2  2  2                       2              2|     22  2.3|
      Bile Duct, Hyperplasia, Multifocal   |             3        2                                                  2|      7  2.4|
      Centrilobular, Pigmentation,         |                                                                          |            |
          Hemosiderin, Multifocal          |                                                                          |      1  3.0|
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Hepatocyte, Necrosis, Multifocal     |          2                                2                              |      2  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                         3           3        3  2                        |      6  3.0|
      Hepatocyte, Centrilobular, Necrosis, |                                                                          |            |
           Multifocal, Subacute            |                                                                          |      1  4.0|
      Left Lateral Lobe, Angiectasis, Focal|                                                             4            |      1  4.0|
      Median Lobe, Atrophy, Chronic,       |                                                                          |            |
          Multifocal                       |                                              3                           |      1  3.0|
      Periportal, Infiltration Cellular,   |                                                                          |            |
           Acute, Multifocal, Lymphocyte   |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sinusoid, Subserosa, Congestion,     |                                                                          |            |
           Acute, Multifocal               |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                         2                                                |      1  2.0|
      Acinus, Atrophy, Focal               |                                                                          |      2  2.5|
      Acinus, Atrophy, Multifocal          |                            2                    2        3               |      6  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Hyperkeratosis,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Forestomach, Hyperplasia, Multifocal,|                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Thrombosis, Multifocal, |                                                                          |            |
           Subacute                        |                                                                          |      1     |
      Myocardium, Degeneration, Chronic,   |                                                                          |            |
           Multifocal                      | 2  2  2  2        2  2  3  2  2     2  3  2  2  3     1  3  3  3  3  2  2|     38  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Cortex, Degeneration,     |                                                                          |            |
           Fatty, Multifocal               |                                                                          |      1  2.0|
      Bilateral, Cortex, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                   3      |      2  2.5|
      Bilateral, Medulla, Hyperplasia,     |                                                                          |            |
           Multifocal                      |                                        2                 2               |      2  2.0|
      Bilateral, Medulla, Infiltration     |                                                                          |            |
          Cellular, Acute, Multifocal,     |                                                                          |            |
           Lymphocyte                      |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Cytoplasmic Alteration, Focal|                                                                          |      1  2.0|
      Cortex, Degeneration, Fatty, Focal   |    3                                            2                       2|      6  2.2|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                               3              2                           |      3  2.3|
      Cortex, Hyperplasia, Focal           |                      2                       3  3        3               |     11  2.5|
      Cortex, Hyperplasia, Multifocal      |                                                                         2|      2  2.0|
      Cortex, Hypertrophy, Focal           |                      3                                                   |      1  3.0|
      Medulla, Hyperplasia, Focal          |                                     2        2                           |      2  2.0|
      Medulla, Hyperplasia, Multifocal     | 2              2                                            2            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +        +     +  +     +  +  +  +        +  +        +     +   |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +        +     +  +  +  +        +        +  +        +  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  I  M|  39        |
      Hyperplasia, Glandular, Multifocal   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Cyst, Multiple        |                   X                                      X           X   |      6     |
      Pars Distalis, Cyst, Single          |                                                                          |      1     |
      Pars Distalis, Hemorrhage, Multifocal|    4                 2                                                   |      4  3.0|
      Pars Distalis, Hemorrhage,           |                                                                          |            |
          Multifocal, Subacute             |                               3                 3                        |      2  3.0|
      Pars Distalis, Hyperplasia, Diffuse  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                  3                                       |      2  2.5|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                        3                                2|      4  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  3.0|
      C-Cell, Hyperplasia, Multifocal      | 2  2  2  2        1     2     2        2     2  2     2  2  2  2         |     25  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +|  40        |
      Cyst                                 |             X                                                            |      1     |
      Hyperplasia, Focal, Glandular        |                                        2     3                           |      3  2.3|
      Inflammation, Chronic Active, Focal  |                                              2                           |      1  2.0|
      Inflammation, Multifocal, Suppurative|                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |       X        X                                                         |      2     |
      Follicle, Cyst, Multiple             |                         X                 X                              |      5     |
      Periovarian Tissue, Cyst             |                         X                                X               |      3     |
      Periovarian Tissue, Left, Cyst       |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Lumen, Ectasia, Multifocal|                                                                          |      1  3.0|
      Cervix, Diverticulum                 |                                                       X                  |      1     |
      Cervix, Fibrosis, Chronic, Multifocal|                                                             4            |      1  4.0|
      Cervix, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                       2                  |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 2  2  2           2  1  1  2     2           2  2  2  2     2  2  2  2  3|     32  1.9|
      Lumen, Ectasia, Focal                |                                                                          |      1  2.0|
      Lumen, Ectasia, Multifocal           |                                     3     4                              |      5  3.2|
      Lumen, Right, Ectasia, Multifocal    |                                                                         3|      1  3.0|
      Lumen, Left, Ectasia, Focal          |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +     +                          +     +                     |   8        |
      Neutrophilia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal, Neutrophil  |                            3                                             |      3  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                            2                                             |      1  2.0|
      Myelofibrosis, Multifocal            |                                        4                                 |      2  3.5|
      Erythroid Cell, Hypoplasia,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Angiectasis, Multifocal  | 2                                                                        |      1  2.0|
      Mandibular, Depletion Lymphoid,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Mandibular, Hemorrhage, Multifocal   |                2        2                    3        1        2         |     16  2.3|
      Mandibular, Hyperplasia, Histiocytic,|                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |                         3           3                                    |      3  2.7|
      Mandibular, Hyperplasia, Multifocal, |                                                                          |            |
           Plasma Cell                     |                                                 3                        |      2  3.0|
      Mandibular, Inflammation, Chronic,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Multifocal                      |                                        3     3           2  2            |      4  2.5|
      Mandibular, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |                            3                                             |      4  2.8|
      Mandibular, Pigmentation,            |                                                                          |            |
          Hemosiderin, Multifocal          | 3                                                                        |      1  3.0|
      Mediastinal, Hemorrhage, Multifocal  |                      2                                                   |      2  3.0|
      Mediastinal, Inflammation, Chronic,  |                                                                          |            |
           Multifocal                      |                                              4                           |      1  4.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous, Multifocal        |                            2                                            3|      4  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multifocal        | 3  3     3     3     2  2     3     3  3  2  2        2     3            |     30  2.5|
      Red Pulp, Inflammation,              |                                                                          |            |
          Granulomatous, Multifocal        |                            4                                   4         |      2  4.0|
      Red Pulp, Necrosis, Acute, Multifocal|             4                                                            |      1  4.0|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Depletion Lymphoid, Multifocal       | 2  2           2  3  2     3  3  2     3  3  3  3  3  3  3  3  3  3     3|     36  2.6|
      Pigmentation, Hemosiderin, Multifocal|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  46        |
      Acinus, Hyperplasia, Cystic,         |                                                                          |            |
          Multifocal                       | 3  2  3  3  2  3  2  3        3     2  2              2  3  3  2  3      |     27  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abdominal, Ulcer, Acute, Focal       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteopetrosis, Multifocal     |                               4  3  2  3     2  4        2  2        3   |     11  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cerebellum, Hemorrhage, Multifocal   |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cerebrum, Compression, Focal         |    3                          3     3           2           3            |      7  2.9|
      Cerebrum, Hemorrhage, Focal          |                                                    2                     |      1  2.0|
      Cerebrum, Perivascular Cuffing, Focal|                                                          2               |      1  2.0|
      Medulla, Hemorrhage, Focal           |                                                                          |      1  3.0|
      Ventricle, Hydrocephalus, Multifocal |          2                    2                             3            |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin, Multifocal|                                              3                           |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.5|
      Bronchiole, Epithelium, Hyperplasia, |                                                                          |            |
           Multifocal                      |                                              3                           |      1  3.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Interstitium, Inflammation,          |                                                                          |            |
          Multifocal, Subacute             |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Focal, Subacute                 |          3     2        2        2                          2            |      7  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Multifocal, Subacute            |       2                    2        2        3        2        2         |      9  2.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Multifocal                      |    2                 2                       3        2        2     2  2|     17  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         |    2  3  2           2  2  2     2  2        2  2     2     2  2        2|     24  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Wall, Hemorrhage, Multifocal         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   4        |
      Lens, Cataract                       |                                                          3               |      3  3.3|
      Retina, Atrophy, Multifocal          |                                                          4               |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  42        |
      Inflammation, Focal, Subacute        |                2                    2                                    |      2  2.0|
      Inflammation, Multifocal, Subacute   | 2  2                             2                       2               |      8  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2|            |
                                           | 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Inflammation, Multifocal, |                                                                          |            |
           Subacute                        |                                              2              2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Nephropathy, Chronic,     |                                                                          |            |
           Multifocal                      | 3  2  2  3     2  1     1  1  3  2  2  1  2     3     1  1  2     1      |     33  1.8|
      Bilateral, Nephropathy, Multifocal   |                                                                          |      1  1.0|
      Cortex, Infarct, Focal               |             3                                                            |      1  3.0|
      Cortex, Inflammation, Chronic, Focal |                                  3                                       |      1  3.0|
      Cortex, Left, Cyst, Single           |                                                                          |      1     |
      Renal Tubule, Degeneration, Acute,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Calculus Micro Observation Only      |                X                                                         |      1     |
      Mucosa, Hyperplasia, Multifocal      |                2                                                         |      1  2.0|
      Mucosa, Hyperplasia, Multifocal,     |                                                                          |            |
           Squamous                        |                                                                          |      1  4.0|
      Mucosa, Metaplasia, Multifocal,      |                                                                          |            |
          Squamous                         |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Rectum, Parasite Metazoan            |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +     +  +  +  +     +  +     +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +     +  +  +     +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +     +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |          2                                         2                     |             
      Angiectasis, Multifocal              |                      2                                                   |             
      Basophilic Focus                     |                      X                                                   |             
      Basophilic Focus, Focal              |             X                                                            |             
      Basophilic Focus, Multiple           |       X                 X     X           X        X  X        X     X   |             
      Basophilic Focus, Single             |                                        X                                 |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus, Multiple         |    X                                                                     |             
      Eosinophilic Focus, Single           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                             2  2         |             
      Mixed Cell Focus                     |                         X                                                |             
      Bile Duct, Hyperplasia, Chronic,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |    3     3  2  2        2  2  2           2  3  3  2  2  4  2  3        4|             
      Bile Duct, Hyperplasia, Multifocal,  |                                                                          |             
           Nodular                         |                                     3                                    |             
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |             
           Focal                           |                      2                                                   |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |    2     3     2                          2     2                       3|             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Multifocal                      |                   1        3                          2                  |             
      Hepatocyte, Necrosis, Multifocal,    |                                                                          |             
           Subacute                        |                                              3                           |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |                         2                    3                       4   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +           +     M         |             
      Fat, Necrosis, Acute, Multifocal     |                                                          2               |             
      Fat, Necrosis, Chronic, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Focal               |                                  1                             1         |             
      Acinus, Atrophy, Multifocal          |                      2  2  1        1  1  2  2  3  3  3     4        2   |             
      Acinus, Cytoplasmic Alteration, Focal|                                                                          |             
      Duct, Ectasia, Focal                 |                                                                          |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                               2                                          |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis, Multifocal  |                                                                      2   |             
      Forestomach, Hyperkeratosis,         |                                                                          |             
          Multifocal                       |                                                                      2   |             
      Forestomach, Ulcer, Focal, Subacute  | 3                                                                        |             
      Forestomach, Ulcer, Multifocal,      |                                                                          |             
          Subacute                         |                                              3                           |             
      Forestomach, Muscularis,             |                                                                          |             
          Mineralization, Multifocal       |                                                                          |             
      Glandular, Necrosis, Acute, Focal    |                                                                      2   |             
      Glandular, Ulcer, Acute, Multifocal  |                                                          2               |             
      Glandular, Ulcer, Focal, Subacute    | 3                                                                        |             
      Muscularis, Glandular,               |                                                                          |             
          Mineralization, Multifocal       |                                                                          |             
      Submucosa, Glandular, Inflammation,  |                                                                          |             
           Multifocal, Subacute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Atrium Left, Thrombosis, Single      |                                                                          |             
      Myocardium, Degeneration, Chronic,   |                                                                          |             
           Multifocal                      | 2  3  3  2  3  3     2  3  3  3  2     3  3     3  3  3  3  3  2  2  3  2|             
      Myocardium, Degeneration, Multifocal |                   2                                                      |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Ventricle Left, Thrombosis, Chronic, |                                                                          |             
           Focal                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Cortex, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                        2                                 |             
      Bilateral, Cortex, Vacuolization     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic, Multifocal          |                   3                                                      |             
      Bilateral, Medulla, Hyperplasia,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Cortex, Cytoplasmic Alteration, Focal|                                        1                                 |             
      Cortex, Degeneration, Fatty, Focal   |             2                       2                    2              2|             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |          2                 2                                             |             
      Cortex, Hematopoietic Cell           |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
      Cortex, Hyperplasia, Focal           |       2     2                 2                    2              2      |             
      Cortex, Hyperplasia, Multifocal      |                                                                          |             
      Cortex, Nuclear Alteration, Focal    |                            2                                             |             
      Cortex, Vacuolization Cytoplasmic,   |                                                                          |             
           Diffuse                         | 4                                                                        |             
      Cortex, Vacuolization Cytoplasmic,   |                                                                          |             
           Multifocal                      |                                                                      3   |             
      Medulla, Cyst, Single                |                      X                                                   |             
      Medulla, Hyperplasia, Focal          |       2              2                             2                 2   |             
      Medulla, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +                 +        +  +  +     +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +  +              +  +        +  +              +  +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  M  +  +  +  M  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                      2   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia, Focal    |                                           2        3                     |             
      Pars Intermedia, Cyst                |       X                                                                  |             
      Pars Intermedia, Cyst, Multiple      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                           2              2           2   |             
      C-Cell, Hyperplasia, Multifocal      | 2     2                 2                             2                  |             
      Follicle, Cyst                       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +  +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Hyperplasia, Glandular, Multifocal   |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell, Mononuclear Cell,          |                                                                          |             
          Multifocal                       |    3                                                                     |             
      Inflammation, Chronic, Multifocal    |             2                                                            |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                            4                          3                  |             
      Inflammation, Multifocal, Subacute   |                               1     2                                    |             
      Bilateral, Hyperplasia, Glandular,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active, Multifocal               |                3     2  2              2        2  2        2  2     2  2|             
      Bilateral, Duct, Ectasia, Focal      |                                     3                                    |             
      Bilateral, Duct, Ectasia, Multifocal |                                                                          |             
      Duct, Ectasia, Multifocal            |                                                                          |             
      Duct, Right, Ectasia, Diffuse        |                                                    4                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |    3        2                                                            |             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                      3   |             
      Inflammation, Multifocal, Subacute   | 2                                      2                                 |             
      Epithelium, Hyperplasia, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Atrophy, Multifocal       |                                     3                                    |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia, Multifocal          | 2                                                                        |             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Atrophy, Multifocal              |       3  3  3  3        4     4                 4  3        3  4     3   |             
      Interstitial Cell, Right,            |                                                                          |             
          Hyperplasia, Multifocal          |                2                                                         |             
      Interstitial Cell, Left, Hyperplasia,|                                                                          |             
           Multifocal                      |                                        3                                 |             
      Seminiferous Tubule, Atrophy,        |                                                                          |             
          Multifocal                       |    3                 3                    3              2               |             
      Seminiferous Tubule, Right, Atrophy, |                                                                          |             
           Multifocal                      |                            4           4                                 |             
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |             
           Multifocal                      |                            2                 4                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +  +  +  +  +     +        M  +        +  +              +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Neutrophilia                         |                                              X                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Multifocal, Neutrophil  |                                              4     2                     |             
      Myelofibrosis, Multifocal            |                                                                          |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hypoplasia, Multifocal           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid, Multifocal    |       3                                                                  |             
      Mandibular, Cyst                     |                               X                                          |             
      Mandibular, Hemorrhage, Multifocal   |                                                       3                  |             
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                      2                             2        3            |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Multifocal, Plasma Cell         |                                                                          |             
      Mandibular, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                2                                                         |             
      Mediastinal, Hemorrhage, Multifocal  |                2     2                                                   |             
      Mediastinal, Hyperplasia, Lymphoid,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous, Multifocal        |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
      Mesenteric, Cyst                     |                                                                          |             
      Mesenteric, Cyst, Multiple           |                                                                          |             
      Mesenteric, Hemorrhage, Multifocal   |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                                                                2         |             
      Mesenteric, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                2                                                         |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        |                                                                2         |             
      Pancreatic, Cyst                     |                               X                                          |             
      Pancreatic, Hemorrhage, Multifocal   |                            3  2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Diffuse, Subacute          | 3                                                                        |             
      Red Pulp, Fibrosis, Chronic,         |                                                                          |             
          Multifocal                       |                                        3                                 |             
      Red Pulp, Fibrosis, Focal            |                                                                          |             
      Red Pulp, Fibrosis, Multifocal       |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multifocal        |                                              3                           |             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  I  +  +|             
      Depletion Lymphoid, Multifocal       |    3  2  3     3     2  2  3  3     3  3        3              2     3  2|             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic, Multifocal,            |                                                                          |             
          Proliferative                    |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M     +  +     +  +     M  +  +  +  +  +  M  +  M  +  M  M  +  M  +|             
      Acinus, Hyperplasia, Cystic,         |                                                                          |             
          Multifocal                       | 3           3  2     2  1           2  4     2     1     3        2     3|             
      Acinus, Hyperplasia, Multifocal      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Ulcer, Chronic Active,     |                                                                          |             
           Focal                           |                                                       3                  |             
      Tail, Hyperkeratosis, Multifocal     | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis, Multifocal     |                                                          3              3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage, Acute,       |                                                                          |             
          Multifocal                       |                                                                         3|             
      Cerebrum, Hemorrhage, Acute,         |                                                                          |             
          Multifocal                       |                                                                         3|             
      Cerebrum, Hemorrhage, Focal          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                3  3                                                      |             
      Bronchiole, Epithelium, Hyperplasia, |                                                                          |             
           Multifocal                      |                                                 2                        |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Metaplasia, Focal,     |                                                                          |             
           Osseous                         |                                                                          |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                                                    2           2        2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal, Subacute            |       2  2  3  2     2        3        2  3  2              2        2   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Multifocal                      |       1  2  2  1     3     1           2  2  2  2  1  3     2  2     1  1|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Chronic, Focal                  |                                                                         2|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Multifocal, Subacute            |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Multifocal, Squamous            |                                                    2                     |             
      Submucosa, Olfactory Epithelium,     |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         |                                                 2                        |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Acute, Multifocal |                                           2                              |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Multifocal                       |                                        2                                 |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal        |                            2                                             |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         |    2  3     3        3  2     2              3        3     2  2         |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              M                 +                          M     +   |             
      Cornea, Inflammation, Multifocal,    |                                                                          |             
           Subacute                        |                                                                      2   |             
      Lens, Cataract, Multifocal           |    3                                                                 3   |             
      Retina, Atrophy, Multifocal          |    4                                3                                3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +     +   |             
      Hyperplasia, Glandular, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                M         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|             
                                           | 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                           X                              |             
      Bilateral, Nephropathy, Chronic,     |                                                                          |             
           Multifocal                      | 2  3  4  3  3  3  2  4  4  4  4  1  4  4  3     4  2  4  2  4  4  2  4  2|             
      Cortex, Cyst                         |       X                                                                  |             
      Cortex, Cyst, Multiple               |                               X                                          |             
      Cortex, Cyst, Single                 |                                                                      X   |             
      Left, Nephropathy, Chronic,          |                                                                          |             
          Multifocal                       |                                              2                           |             
      Papilla, Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Multifocal                       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Multifocal      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Rectum, Parasite Metazoan            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +     +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                      2                                            3      |      4  2.3|
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Focal              |                                                                          |      1     |
      Basophilic Focus, Multiple           |       X                 X                             X  X  X        X   |     14     |
      Basophilic Focus, Single             |    X                                                                     |      2     |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Clear Cell Focus, Multiple           |    X                                                                     |      1     |
      Eosinophilic Focus, Multiple         |                      X                                X                  |      3     |
      Eosinophilic Focus, Single           |       X                                                                  |      1     |
      Hyperplasia, Focal                   |                                                    2                     |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2              2           2                                          |      5  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Hyperplasia, Chronic,     |                                                                          |            |
           Multifocal                      |                                                                   4      |      1  4.0|
      Bile Duct, Hyperplasia, Multifocal   | 3  2  2  3  3  2  3  3  3  4  2  3     2  2  4  3  3                 3  3|     35  2.7|
      Bile Duct, Hyperplasia, Multifocal,  |                                                                          |            |
           Nodular                         |                                                                          |      1  3.0|
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |       2                          3                    2           3      |     10  2.4|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Multifocal                      | 4                    2  3           3  2                             2   |      9  2.4|
      Hepatocyte, Necrosis, Multifocal,    |                                                                          |            |
           Subacute                        |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Cytoplasmic, Multifocal          | 4        4  3  3                                                        3|      8  3.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Fat, Necrosis, Acute, Multifocal     |                                                                          |      1  2.0|
      Fat, Necrosis, Chronic, Multifocal   |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                                                          |      2  1.0|
      Acinus, Atrophy, Multifocal          | 3  2  2  2  2        2  2  2  2  2     4        3     2              2  2|     27  2.2|
      Acinus, Cytoplasmic Alteration, Focal|                               2           2                              |      2  2.0|
      Duct, Ectasia, Focal                 |                                                                   2      |      1  2.0|
      Duct, Ectasia, Multifocal            |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Acanthosis, Multifocal  |                            2                                             |      2  2.0|
      Forestomach, Hyperkeratosis,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Forestomach, Ulcer, Focal, Subacute  |                                                                          |      1  3.0|
      Forestomach, Ulcer, Multifocal,      |                                                                          |            |
          Subacute                         |                                                                          |      1  3.0|
      Forestomach, Muscularis,             |                                                                          |            |
          Mineralization, Multifocal       |                                                                4         |      1  4.0|
      Glandular, Necrosis, Acute, Focal    |                                                                          |      1  2.0|
      Glandular, Ulcer, Acute, Multifocal  |                                                                          |      1  2.0|
      Glandular, Ulcer, Focal, Subacute    |                                                                          |      1  3.0|
      Muscularis, Glandular,               |                                                                          |            |
          Mineralization, Multifocal       |                                                                4         |      1  4.0|
      Submucosa, Glandular, Inflammation,  |                                                                          |            |
           Multifocal, Subacute            |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Mineralization, Multifocal   |                                                                2         |      1  2.0|
      Atrium Left, Thrombosis, Single      |          X              X                                                |      2     |
      Myocardium, Degeneration, Chronic,   |                                                                          |            |
           Multifocal                      | 2  2  2  2     2  3  2  2  3  3  3  3  3  3  2  3  2  2  2  3  4  2  2  2|     46  2.6|
      Myocardium, Degeneration, Multifocal |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                3         |      1  3.0|
      Ventricle Left, Thrombosis, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Cortex, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                           3        2                     |      3  2.3|
      Bilateral, Cortex, Vacuolization     |                                                                          |            |
          Cytoplasmic, Multifocal          |                                                                          |      1  3.0|
      Bilateral, Medulla, Hyperplasia,     |                                                                          |            |
           Multifocal                      |                                     2                                    |      1  2.0|
      Cortex, Cytoplasmic Alteration, Focal|                                                                          |      1  1.0|
      Cortex, Degeneration, Fatty, Focal   |                                                       2                  |      5  2.0|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |          3     2                 2                                       |      5  2.2|
      Cortex, Hematopoietic Cell           |                                                                          |            |
          Proliferation, Multifocal        |                                                          2               |      1  2.0|
      Cortex, Hyperplasia, Focal           |                                                                2         |      6  2.0|
      Cortex, Hyperplasia, Multifocal      |                               2                                          |      1  2.0|
      Cortex, Nuclear Alteration, Focal    |                                                                          |      1  2.0|
      Cortex, Vacuolization Cytoplasmic,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
      Cortex, Vacuolization Cytoplasmic,   |                                                                          |            |
           Multifocal                      | 2           2  2                                                         |      4  2.3|
      Medulla, Cyst, Single                |                                                                          |      1     |
      Medulla, Hyperplasia, Focal          |             2                                               2            |      6  2.0|
      Medulla, Hyperplasia, Multifocal     |                      2        2  2                 2     3           2   |      6  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +              +  +  +                 +  +           +     +  +   |  20        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +        +                                                  +      |  14        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  42        |
      Cytoplasmic Alteration, Focal        |                                                          3               |      1  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                        3                                 |      1  3.0|
      Hyperplasia, Multifocal              |                                                       2        3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |       2        2     3                                      2  1         |      7  2.1|
      Pars Intermedia, Cyst                |                                                          X               |      2     |
      Pars Intermedia, Cyst, Multiple      |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |    2        2                                         2                  |      6  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                         2|      5  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  43        |
      Abscess                              |                      X                                                   |      1     |
      Hyperplasia, Focal, Glandular        |                               2                                          |      1  2.0|
      Hyperplasia, Glandular, Multifocal   |                      2                                                   |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell, Mononuclear Cell,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                              3  2                        |      4  3.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  1.5|
      Bilateral, Hyperplasia, Glandular,   |                                                                          |            |
           Multifocal                      |                                                             3            |      1  3.0|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active, Multifocal               | 2     1  2     2  2  2     2  3  2  2  2  3        2  2  2  2        3   |     27  2.1|
      Bilateral, Duct, Ectasia, Focal      |                                                                          |      1  3.0|
      Bilateral, Duct, Ectasia, Multifocal |          4                          3  3  3           3  3               |      6  3.2|
      Duct, Ectasia, Multifocal            |             3                                                            |      1  3.0|
      Duct, Right, Ectasia, Diffuse        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Multifocal    |          2              2                    3           3               |      6  2.5|
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |                                                                4        3|      2  3.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia, Multifocal  |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Atrophy, Multifocal       |                                                                          |      1  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                         2|      2  2.0|
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Atrophy, Multifocal              | 4  4     3  3        4  3  3     4  4  3  4  4     3  3  4           3   |     27  3.4|
      Interstitial Cell, Right,            |                                                                          |            |
          Hyperplasia, Multifocal          | 2  2  2           2  2     2                                      2      |      8  2.0|
      Interstitial Cell, Left, Hyperplasia,|                                                                          |            |
           Multifocal                      |                         2                       2           2  2         |      5  2.2|
      Seminiferous Tubule, Atrophy,        |                                                                          |            |
          Multifocal                       |                                                                          |      4  2.8|
      Seminiferous Tubule, Right, Atrophy, |                                                                          |            |
           Multifocal                      |       4                                         4           4            |      5  4.0|
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |            |
           Multifocal                      |                   4           4                 2                 4      |      6  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +        +     +     +  +  +  +  +  +  +  +  +     +                    +|  26        |
      Neutrophilia                         |                X                                                         |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal, Neutrophil  |                                                                3        3|      4  3.0|
      Myelofibrosis, Multifocal            |                                                                4         |      1  4.0|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hypoplasia, Multifocal           |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      1  3.0|
      Mandibular, Cyst                     |                            X                                X            |      3     |
      Mandibular, Hemorrhage, Multifocal   |    3                                                        3            |      3  3.0|
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |    2                 3                                2                  |      6  2.3|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Multifocal, Plasma Cell         |                                        3                                 |      1  3.0|
      Mandibular, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage, Multifocal  |                      3                                                   |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid,  |                                                                          |            |
           Multifocal                      |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous, Multifocal        |                                           3                              |      1  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Multifocal, Subacute             |                                                                3         |      1  3.0|
      Mesenteric, Cyst                     |          X                                                               |      1     |
      Mesenteric, Cyst, Multiple           |                                     X                                    |      1     |
      Mesenteric, Hemorrhage, Multifocal   |                                              3                           |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Mesenteric, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |                                                                          |      1  2.0|
      Pancreatic, Cyst                     |                                                                          |      1     |
      Pancreatic, Hemorrhage, Multifocal   |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Diffuse, Subacute          |                                                                          |      1  3.0|
      Red Pulp, Fibrosis, Chronic,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Red Pulp, Fibrosis, Focal            |                   3                          2                           |      2  2.5|
      Red Pulp, Fibrosis, Multifocal       |                                  3                             2        3|      3  2.7|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multifocal        |                3                                                         |      2  3.0|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  I  +  I  I  +  +  +  +  +  +  I  +  +  I  +  +  +  +  M  +|  39        |
      Depletion Lymphoid, Multifocal       | 3  2     3  3              3  3  3  3  3  3     3  2     2     3  3     3|     30  2.7|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic, Multifocal,            |                                                                          |            |
          Proliferative                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  +  M  M  M  M  +  +  M  +  +  +  M  +  +  M  +  M  M  +|  25        |
      Acinus, Hyperplasia, Cystic,         |                                                                          |            |
          Multifocal                       |          3        2              3           3        3        3        3|     19  2.5|
      Acinus, Hyperplasia, Multifocal      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inguinal, Ulcer, Chronic Active,     |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Tail, Hyperkeratosis, Multifocal     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femur, Osteopetrosis, Multifocal     |             3                                                            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage, Acute,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Cerebrum, Hemorrhage, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Cerebrum, Hemorrhage, Focal          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                            3                                             |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  3.0|
      Bronchiole, Epithelium, Hyperplasia, |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                         3        2  2              2        2  3         |      6  2.3|
      Interstitium, Metaplasia, Focal,     |                                                                          |            |
           Osseous                         |                                                       1                  |      1  1.0|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic, Multifocal             |                3                                                         |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Focal, Subacute                 |                                        3                                 |      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Multifocal                      |                      2                                                   |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Multifocal, Subacute            |       2  1  2     2     2     3           2                    2     3   |     20  2.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Multifocal                      |             3     2  2                 1     1  1  3        2  1         |     25  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  2.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Multifocal, Subacute            |       2  2                                                               |      2  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Multifocal, Squamous            |                                                                3         |      2  2.5|
      Submucosa, Olfactory Epithelium,     |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         |                                                                          |      1  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Acute, Multifocal |                                                                          |      1  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Multifocal                       |                   2  2              2                                    |      4  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal        |                                                                          |      1  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         | 2              2        2  2  2        2  3  2  2                        |     19  2.3|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Suppurative                      |             3                                         3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +              I                                                         |   4        |
      Cornea, Inflammation, Multifocal,    |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Lens, Cataract, Multifocal           |                                                                          |      2  3.0|
      Retina, Atrophy, Multifocal          |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +   |  43        |
      Hyperplasia, Glandular, Multifocal   |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |                                                                          |      1     |
      Bilateral, Nephropathy, Chronic,     |                                                                          |            |
           Multifocal                      | 3  2  3  3  3  2  3  4  4  3  4  4  3  4  3  3  2  4  4  4  4  4  3  3  2|     49  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6|            |
                                           | 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Cyst                         |             X        X                                                   |      3     |
      Cortex, Cyst, Multiple               |                         X                                                |      2     |
      Cortex, Cyst, Single                 |                                           X           X     X            |      4     |
      Left, Nephropathy, Chronic,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Papilla, Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                  2                                       |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mucosa, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|             
                                           | 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
      Colon, Mesothelium, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
      Lamina Propria, Rectum, Inflammation,|                                                                          |             
           Multifocal, Subacute            |                                                                          |             
      Rectum, Mesothelium, Inflammation,   |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Jejunum, Inflammation, Chronic       |                                                                          |             
          Active, Multifocal, Proliferative|                                                                          |             
      Jejunum, Necrosis                    |                                                                          |             
      Jejunum, Lamina Propria, Metaplasia, |                                                                          |             
           Multifocal, Osseous             |                                                                          |             
      Jejunum, Subserosa, Diverticulum     |                                                                          |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |    X  X                          X        X                              |             
      Basophilic Focus, Single             | X                          X                                             |             
      Clear Cell Focus, Multiple           |                                        X                                 |             
      Clear Cell Focus, Single             |          X                                                               |             
      Eosinophilic Focus, Single           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |          2                                               2              1|             
      Bile Duct, Hyperplasia, Multifocal   | 2  2  3     4     3  3                       3  3  2     2     3     4   |             
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |    2              2  2                                   2        2      |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Multifocal                      |                         2                                                |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |          2                    4        3     3     3                     |             
      Left Lateral Lobe, Necrosis, Acute,  |                                                                          |             
           Focal                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                           3                              |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                            +                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
      Forestomach, Acanthosis, Focal       |                                                                          |             
      Forestomach, Hyperkeratosis, Focal   |                                                                          |             
      Glandular, Necrosis, Acute,          |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|             
                                           | 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +                                                            |             
      Atrium Left, Thrombosis, Chronic     |             X                                                            |             
      Myocardium, Degeneration, Chronic,   |                                                                          |             
           Multifocal                      |    2        2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +              +                                       |             
      Cortex, Degeneration, Fatty, Focal   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X                    X   |             
      Pars Distalis, Cyst, Multiple        |                                  X                                       |             
      Pars Distalis, Hyperplasia, Focal    |                            2                                             |             
      Pars Distalis, Karyomegaly,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Intermedia, Hemorrhage, Chronic,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Follicle, Cyst, Multiple  | X                                                                        |             
      C-Cell, Hyperplasia, Focal           |             3                    2                                       |             
      C-Cell, Hyperplasia, Multifocal      |                   2     2              2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
      Head, Granuloma Sperm, Single        |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                    +                                   +   |             
                                            __________________________________________________________________________|             
   Prostate                                |                      +                                            +      |             
      Dilatation, Multifocal               |                                                                   3      |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                      4                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                   +      |             
      Dilatation, Multifocal               |                                                                   3      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +           +  +  +  +     +  +  +     +  +  +  +|             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Atrophy, Multifocal              | 4  4  4                 3                 3  3                       4  3|             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                                          2               |             
      Interstitial Cell, Right,            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|             
                                           | 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Hyperplasia, Multifocal          |          2                                                              3|             
      Interstitial Cell, Left, Hyperplasia,|                                                                          |             
           Multifocal                      |                                     2                          2         |             
      Interstitial Tissue, Hemorrhage,     |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
      Interstitial Tissue, Right,          |                                                                          |             
          Hemorrhage, Chronic Active,      |                                                                          |             
           Multifocal                      |                                                                   4      |             
      Left, Atrophy, Multifocal            |                                        4                                 |             
      Seminiferous Tubule, Atrophy,        |                                                                          |             
          Multifocal                       |                                                    3  4  4               |             
      Seminiferous Tubule, Right, Atrophy, |                                                                          |             
           Multifocal                      |                                     4                          4  3      |             
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |             
           Multifocal                      |          4        4                                                      |             
      Vein, Ectasia, Chronic, Multifocal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +              +                                +      |             
      Inguinal, Inflammation,              |                                                                          |             
          Granulomatous, Multifocal        |                                  3                                       |             
      Lumbar, Inflammation, Granulomatous, |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinal, Inflammation, Chronic,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active, Multifocal               |                                                                   4      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin, Multifocal          |                                                                   3      |             
      Mesenteric, Hemorrhage, Multifocal   |                                                                          |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +     +                          +                       +   |             
      Capsule, Cyst, Multiple              |                                                                          |             
      Red Pulp, Fibrosis, Chronic, Focal   |       2                                                                  |             
      Red Pulp, Fibrosis, Chronic,         |                                                                          |             
          Multifocal                       |                                                                      3   |             
      Red Pulp, Fibrosis, Focal            |                                                                          |             
      Red Pulp, Fibrosis, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                      +   |             
      Epithelial Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|             
                                           | 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   +                          +                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +  +        +  +  +              +           +            |             
      Thoracic, Subcutaneous Tissue,       |                                                                          |             
          Hemorrhage, Chronic Active,      |                                                                          |             
           Diffuse                         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +                                                      |             
      Cerebellum, Cerebrum, Hemorrhage,    |                                                                          |             
           Multifocal                      |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                                                            |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |             3                                                            |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal, Subacute            |    3     3        2           2           2     2        2           4  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Multifocal                      |       3  2  2  2  3  2  3     2  1  3  1  3     3  2  2  3  3  3  2  2  2|             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Concretion, Multifocal          |                                                                3         |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Acute, Multifocal |                                  3  3                                    |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Focal, Subacute   |                                              3                       2   |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         | 3  3  1     2  2     2  3                       2  2  2  2  2  2  2     2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +                       +        +                  |             
      Lens, Cataract, Multifocal           |                3                                      3                  |             
      Retina, Atrophy, Multifocal          |                3                                      4                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|             
                                           | 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +                          +                          +  +   |             
      Congestion, Multifocal               |                                                                          |             
      Cyst                                 |                                                                          |             
      Polycystic Kidney                    |                                                                      X   |             
      Bilateral, Nephropathy, Chronic,     |                                                                          |             
           Multifocal                      |             3                          4                          4  4   |             
      Bilateral, Cortex, Cyst, Multiple    |                                                                      X   |             
      Bilateral, Cortex, Mineralization,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Pelvis, Hydronephrosis,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Right, Cyst                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                     +                                    |             
      Inflammation, Acute, Hemorrhagic,    |                                                                          |             
           Multifocal                      |                                     4                                    |             
      Mucosa, Hyperplasia, Multifocal      |                                                                          |             
      Muscularis, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2|            |
                                           | 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                                                                     |   1        |
      Colon, Mesothelium, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |    3                                                                     |      1  3.0|
      Lamina Propria, Rectum, Inflammation,|                                                                          |            |
           Multifocal, Subacute            |    3                                                                     |      1  3.0|
      Rectum, Mesothelium, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +                                                               |   1        |
      Necrosis                             |          X                                                               |      1     |
      Jejunum, Inflammation, Chronic       |                                                                          |            |
          Active, Multifocal, Proliferative|          4                                                               |      1  4.0|
      Jejunum, Necrosis                    |          X                                                               |      1     |
      Jejunum, Lamina Propria, Metaplasia, |                                                                          |            |
           Multifocal, Osseous             |          4                                                               |      1  4.0|
      Jejunum, Subserosa, Diverticulum     |          X                                                               |      1     |
      Mucosa, Necrosis                     |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |    X           X           X              X              X  X  X     X   |     12     |
      Basophilic Focus, Single             |                                                                          |      2     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Clear Cell Focus, Single             |                                                                          |      1     |
      Eosinophilic Focus, Single           |                                                                      X   |      1     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 2                          2                       3                    3|      7  2.1|
      Bile Duct, Hyperplasia, Multifocal   |          3  3  3  3  3  2  2        3  2  2  3  4  3  2     2  3  3     2|     30  2.7|
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |            |
           Multifocal                      |                                                          2           2   |      2  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |       2                                                     2            |      7  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Multifocal                      |                            1              3              3              2|      5  2.2|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                      3        3           2                              |      8  2.9|
      Left Lateral Lobe, Necrosis, Acute,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2|            |
                                           | 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                         +              +                                 |   2        |
      Forestomach, Acanthosis, Focal       |                         2                                                |      1  2.0|
      Forestomach, Hyperkeratosis, Focal   |                         2                                                |      1  2.0|
      Glandular, Necrosis, Acute,          |                                                                          |            |
          Multifocal                       |                         2              2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   2        |
      Atrium Left, Thrombosis, Chronic     |                                                                          |      1     |
      Myocardium, Degeneration, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                      +                                                   |   3        |
      Cortex, Degeneration, Fatty, Focal   |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  I  +  +  +  +  +     +  +  +  +  +     +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                            X                    X                        |      4     |
      Pars Distalis, Cyst, Multiple        |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |    3  2                             2           3        3              3|      7  2.6|
      Pars Distalis, Karyomegaly,          |                                                                          |            |
          Multifocal                       |                            2                                             |      1  2.0|
      Pars Intermedia, Hemorrhage, Chronic,|                                                                          |            |
           Focal                           |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Follicle, Cyst, Multiple  |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |             3                                            2               |      4  2.5|
      C-Cell, Hyperplasia, Multifocal      |                               2                                      2   |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                    +                     |   1        |
      Head, Granuloma Sperm, Single        |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                 +                        |   3        |
      Dilatation, Multifocal               |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2|            |
                                           | 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                 2                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Dilatation, Multifocal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +  +  +        +  +     +  +  +  +        +  +  +  +     +  +|  38        |
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Atrophy, Multifocal              | 4        4  4     3        3  3     3     4  4           4  4        3   |     20  3.6|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                               2     2                 2                  |      4  2.0|
      Interstitial Cell, Right,            |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                2         |      3  2.3|
      Interstitial Cell, Left, Hyperplasia,|                                                                          |            |
           Multifocal                      |                2           2                                             |      4  2.0|
      Interstitial Tissue, Hemorrhage,     |                                                                          |            |
           Chronic Active, Multifocal      | 3                                                                        |      1  3.0|
      Interstitial Tissue, Right,          |                                                                          |            |
          Hemorrhage, Chronic Active,      |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Left, Atrophy, Multifocal            |                                                                          |      1  4.0|
      Seminiferous Tubule, Atrophy,        |                                                                          |            |
          Multifocal                       |                                                       3                  |      4  3.5|
      Seminiferous Tubule, Right, Atrophy, |                                                                          |            |
           Multifocal                      |                4                                                         |      4  3.8|
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |            |
           Multifocal                      |                                                                4         |      3  4.0|
      Vein, Ectasia, Chronic, Multifocal   | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +        +     +                          +              +      |   9        |
      Inguinal, Inflammation,              |                                                                          |            |
          Granulomatous, Multifocal        |                                                                          |      1  3.0|
      Lumbar, Inflammation, Granulomatous, |                                                                          |            |
           Multifocal                      | 3                                                                        |      1  3.0|
      Mediastinal, Inflammation, Chronic,  |                                                                          |            |
           Multifocal                      |                                                    3                     |      1  3.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  4.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin, Multifocal          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2|            |
                                           | 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Hemorrhage, Multifocal   |                                                                   3      |      1  3.0|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +        +  +  +           +     +     +           +     +      |  14        |
      Capsule, Cyst, Multiple              |                                                             X            |      1     |
      Red Pulp, Fibrosis, Chronic, Focal   |                                                                          |      1  2.0|
      Red Pulp, Fibrosis, Chronic,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Red Pulp, Fibrosis, Focal            |                                                 2                        |      1  2.0|
      Red Pulp, Fibrosis, Multifocal       |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   1        |
      Epithelial Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                            +                       +                     |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +                                               +                  |  12        |
      Thoracic, Subcutaneous Tissue,       |                                                                          |            |
          Hemorrhage, Chronic Active,      |                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   1        |
      Cerebellum, Cerebrum, Hemorrhage,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                                               +                     |   3        |
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Focal, Subacute                 |                      2                                                   |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2|            |
                                           | 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    5000 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Multifocal, Subacute            | 3        3                    2     2           2        2  2  2     2  2|     19  2.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Multifocal                      |          3  3     3        2  2  2  2  3  3  3  2  1     2  3  2     3  3|     38  2.4|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Concretion, Multifocal          |                                                                          |      1  3.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Acute, Multifocal |    2                                                                     |      3  2.7|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Focal, Subacute   |                                                                          |      2  2.5|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         | 2           2        2           2              3           2  2  2      |     23  2.1|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract, Multifocal           |                                                                          |      2  3.0|
      Retina, Atrophy, Multifocal          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                               +        +           +                 +   |   8        |
      Congestion, Multifocal               |                                        4                                 |      1  4.0|
      Cyst                                 |                                                                      X   |      1     |
      Polycystic Kidney                    |                                                                          |      1     |
      Bilateral, Nephropathy, Chronic,     |                                                                          |            |
           Multifocal                      |                               4                                      4   |      6  3.8|
      Bilateral, Cortex, Cyst, Multiple    |                                                                          |      1     |
      Bilateral, Cortex, Mineralization,   |                                                                          |            |
           Multifocal                      |                                                    3                     |      1  3.0|
      Bilateral, Pelvis, Hydronephrosis,   |                                                                          |            |
           Multifocal                      |                                                    4                     |      1  4.0|
      Cortex, Cyst                         |                                                                      X   |      1     |
      Right, Cyst                          |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                                                                     |   2        |
      Inflammation, Acute, Hemorrhagic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Mucosa, Hyperplasia, Multifocal      |    3                                                                     |      1  3.0|
      Muscularis, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Colon, Peyer's Patch, Hyperplasia,   |                                                                          |             
           Lymphoid, Multifocal            |       3                                                                  |             
      Peyer's Patch, Rectum, Hyperplasia,  |                                                                          |             
           Lymphoid, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                                              X      |             
      Basophilic Focus, Multiple           | X           X        X                          X                        |             
      Basophilic Focus, Single             |                                        X                                 |             
      Clear Cell Focus, Focal              |                                                                          |             
      Clear Cell Focus, Multiple           |                                           X     X              X         |             
      Clear Cell Focus, Single             |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                                                   X      |             
      Eosinophilic Focus, Single           |          X                                                               |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                      1   |             
      Bile Duct, Hyperplasia, Cystic,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |       2           3        2     4  2     2        3  3     2     2     4|             
      Capsule, Hematocyst, Single          |                                                                          |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       |                                                                3         |             
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |             
           Focal                           |    2                                                                     |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                              2                          2|             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Multifocal                      |                                                 2                        |             
      Hepatocyte, Necrosis, Acute,         |                                                                          |             
          Multifocal                       |                                                    2     1               |             
      Hepatocyte, Necrosis, Focal          |                                                             3            |             
      Hepatocyte, Necrosis, Multifocal     |                         2                                                |             
      Hepatocyte, Vacuolization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic, Focal               |                                              2                           |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          | 1  2     4                             2                                 |             
      Median Lobe, Hepatocyte,             |                                                                          |             
          Degeneration, Fatty, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Necrosis, Chronic, Focal             |                                                                          |             
      Fat, Necrosis                        |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |             1                    2                                       |             
      Acinus, Atrophy, Multifocal          | 3        2              2           2  1  1     2  3  2                  |             
      Acinus, Cytoplasmic Alteration,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                           4                              |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Muscularis,             |                                                                          |             
          Inflammation, Chronic, Multifocal|                                                          3               |             
      Glandular, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                          2               |             
      Glandular, Necrosis, Acute,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Thrombosis              |          X                                                               |             
      Atrium Left, Thrombosis, Multiple,   |                                                                          |             
           Subacute                        |                                                                X         |             
      Myocardium, Degeneration, Chronic,   |                                                                          |             
           Multifocal                      | 2  3  3     2  3  2  3     3  3  3  3  2  3  2  2  3  2     3  3  3  2   |             
      Myocardium, Degeneration, Multifocal |                         2                                                |             
      Myocardium, Mineralization,          |                                                                          |             
          Multifocal                       |          2                                                               |             
      Ventricle Left, Thrombosis, Multiple |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Cortex, Hematopoietic     |                                                                          |             
          Cell Proliferation, Multifocal   |                                                                          |             
      Bilateral, Cortex, Vacuolization     |                                                                          |             
          Cytoplasmic, Multifocal          |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Congestion, Multifocal       |                                                                          |             
      Cortex, Cytoplasmic Alteration, Focal|                                                       3                  |             
      Cortex, Degeneration, Fatty, Focal   |                   2        2     2              2                        |             
      Cortex, Degeneration, Fatty,         |                                                                          |             
          Multifocal                       |                                        2                                 |             
      Cortex, Hyperplasia, Focal           |             2              2  3                                          |             
      Cortex, Hyperplasia, Multifocal      |                                                                          |             
      Cortex, Karyomegaly, Focal           |                                                                          |             
      Cortex, Necrosis, Multifocal         |                                  2                                       |             
      Medulla, Hyperplasia, Focal          |                            2           2                          2      |             
      Medulla, Hyperplasia, Multifocal     |    2                                      2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +     +  +           +     +  +           +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +     +  +  +                    +  +  +  +  +              +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hemorrhage, Focal     |                                     4                                    |             
      Pars Distalis, Hyperplasia, Focal    |             3                                                     3      |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |       2                 2  2        2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                           1           2        2         |             
      C-Cell, Hyperplasia, Multifocal      |                                  2                                       |             
      Follicle, Cyst                       |                                              X                    X      |             
      Follicle, Cyst, Multiple             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Inflammation, Multifocal, |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                          +               |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Necrotizing                     |                                                          3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal, Nodular,    |                                                                          |             
           Squamous                        |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                            3              3                              |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal, Necrotizing          |                                                          4               |             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active, Multifocal               |    2  2  2  2  3  2  4  2     3  2  2  3     2     3  2     2     2  2  2|             
      Bilateral, Duct, Ectasia, Focal      |                                                       3                  |             
      Bilateral, Duct, Ectasia, Multifocal |    2                                                                     |             
      Duct, Ectasia, Focal                 |                                                 3                       3|             
      Duct, Ectasia, Multifocal            |                                        3                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                               2                                2         |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                    3                    3|             
      Inflammation, Focal, Subacute        | 2                                                                        |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                      4                                                   |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia, Multifocal          |                                  2                    2                  |             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Atrophy, Chronic, Multifocal     |                                                                          |             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Atrophy, Multifocal              |    4        4                 4     4     4     4  4              3      |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Interstitial Cell, Right,            |                                                                          |             
          Hyperplasia, Multifocal          |                2                                                         |             
      Interstitial Cell, Left, Hyperplasia,|                                                                          |             
           Focal                           |                                              3                           |             
      Interstitial Cell, Left, Hyperplasia,|                                                                          |             
           Multifocal                      |       2                                                                  |             
      Seminiferous Tubule, Atrophy,        |                                                                          |             
          Multifocal                       |          3                 3                                   3         |             
      Seminiferous Tubule, Right, Atrophy, |                                                                          |             
           Multifocal                      |       4                                                                  |             
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |             
           Multifocal                      |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +     +     +           +        +        +  +              +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Neutrophil  |                                                                          |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hypoplasia, Diffuse              |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Multifocal       |                                                                3         |             
      Mandibular, Cyst                     |                                                                          |             
      Mandibular, Depletion Lymphoid,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Mandibular, Hemorrhage, Multifocal   |          2                 2                                             |             
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                                     2           2                 2  3   |             
      Mandibular, Hyperplasia, Multifocal, |                                                                          |             
           Plasma Cell                     | 3     3                                                                  |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Multifocal, Plasma Cell         |                         3                                                |             
      Mandibular, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                          3               |             
      Mandibular, Inflammation,            |                                                                          |             
          Granulomatous, Multifocal        |                                                             2            |             
      Mediastinal, Hemorrhage, Multifocal  |                                           2                              |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous, Multifocal        |       2                                                     2            |             
      Mesenteric, Cyst, Multiple           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Red Pulp, Fibrosis, Multifocal       |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Multifocal        |                                                             3  4     2   |             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |                         4                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I|             
      Depletion Lymphoid, Multifocal       | 3  3     3  3  2  3  3     3  2        2     3  2  4     3  3  3  2  3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  M  M  +  +  M  +  M  +  +  +  M  +  M  +  M  M  M  M  M  M|             
      Acinus, Hyperplasia, Cystic,         |                                                                          |             
          Multifocal                       |                      2  2     2           2           3                  |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Inflammation, Chronic,    |                                                                          |             
           Focal, Suppurative              |                                     4                                    |             
      Abdominal, Subcutaneous Tissue,      |                                                                          |             
          Edema, Multifocal, Subacute      |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Abscess                    |                      X                                                   |             
      Inguinal, Subcutaneous Tissue,       |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Multifocal                      |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Femur, Osteopetrosis, Multifocal     |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Medulla, Cerebrum, Hemorrhage, Acute,|                                                                          |             
           Multifocal                      |                                                                          |             
      Third Ventricle, Hemorrhage, Focal   |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Acute, Diffuse           |                                                             3            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                          3               |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Focal                           |             2                                   2                        |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                  2                                       |             
      Interstitium, Inflammation,          |                                                                          |             
          Multifocal, Subacute             |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous, Multifocal        |                                                          3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Degeneration, Multifocal             |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Focal, Subacute                 |                                                                   2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Multifocal, Subacute            | 2           2           2  2                 2              2            |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Multifocal                      | 2  3  3  3  3  3  2  3  3  2  2  2  2  2  3  3  3  3  3     3  3  3  3  1|             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Acute, Focal      |                                                                          |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Acute, Multifocal | 2                                                                        |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|             
                                           | 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10000                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Inflammation, Focal, Subacute   |                                                             1            |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Subacute                         |          4  3                    3  2  2        2     3           3  2   |             
      Submucosa, Respiratory Epithelium,   |                                                                          |             
           Inflammation, Multifocal,       |                                                                          |             
          Suppurative                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +   |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                       3                  |             
      Inflammation, Multifocal, Subacute   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Nephropathy, Chronic,     |                                                                          |             
           Multifocal                      | 4  2  2  2  3  3  3  3  2  1  3  3  2  3  3  3  4  2  2     3  2  3  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Multifocal      |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submucosa, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Colon, Peyer's Patch, Hyperplasia,   |                                                                          |            |
           Lymphoid, Multifocal            |                                                                3        3|      3  3.0|
      Peyer's Patch, Rectum, Hyperplasia,  |                                                                          |            |
           Lymphoid, Multifocal            |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +        +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +        +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                          X               |      3     |
      Basophilic Focus, Multiple           | X  X     X        X                       X           X                 X|     11     |
      Basophilic Focus, Single             |                                                                          |      1     |
      Clear Cell Focus, Focal              |       X                                                                  |      1     |
      Clear Cell Focus, Multiple           |                                     X                                    |      4     |
      Clear Cell Focus, Single             | X                                         X                             X|      3     |
      Eosinophilic Focus                   |       X                                                                 X|      2     |
      Eosinophilic Focus, Multiple         |    X                                                        X            |      3     |
      Eosinophilic Focus, Single           |                                                                          |      1     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                2                                                         |      2  1.5|
      Bile Duct, Hyperplasia, Cystic,      |                                                                          |            |
          Multifocal                       |                                                                         2|      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   | 3           3           4  2  2  2     2  2  2     3     2           2   |     23  2.5|
      Capsule, Hematocyst, Single          | X                                                                        |      1     |
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Hepatocyte, Cytoplasmic Alteration,  |                                                                          |            |
           Focal                           |       2                                                                  |      2  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |    2        2           3                    2                           |      6  2.2|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Multifocal                      |                                                       2                  |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hepatocyte, Necrosis, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      2  1.5|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  3.0|
      Hepatocyte, Necrosis, Multifocal     |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |          3                       3        3     3  4  2                  |     10  2.7|
      Median Lobe, Hepatocyte,             |                                                                          |            |
          Degeneration, Fatty, Multifocal  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   2        |
      Necrosis, Chronic, Focal             |                                     X                                    |      1     |
      Fat, Necrosis                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |    2                                1  2  2           2                  |      7  1.7|
      Acinus, Atrophy, Multifocal          |          2              2                    2  2        2     1     3   |     16  2.0|
      Acinus, Cytoplasmic Alteration,      |                                                                          |            |
          Multifocal                       |    2                                                                     |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Duct, Ectasia, Multifocal            |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Forestomach, Muscularis,             |                                                                          |            |
          Inflammation, Chronic, Multifocal|                                                                          |      1  3.0|
      Glandular, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Glandular, Necrosis, Acute,          |                                                                          |            |
          Multifocal                       |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Thrombosis              |                                                                          |      1     |
      Atrium Left, Thrombosis, Multiple,   |                                                                          |            |
           Subacute                        |                                                                          |      1     |
      Myocardium, Degeneration, Chronic,   |                                                                          |            |
           Multifocal                      |    2  3  3  3  3  3  4  2  3  2  2  3  3  3  3  3  2  3  2  3  2     3  3|     44  2.7|
      Myocardium, Degeneration, Multifocal |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Mineralization,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Ventricle Left, Thrombosis, Multiple |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Cortex, Hematopoietic     |                                                                          |            |
          Cell Proliferation, Multifocal   |                                                          2               |      1  2.0|
      Bilateral, Cortex, Vacuolization     |                                                                          |            |
          Cytoplasmic, Multifocal          |                                                                          |      1  3.0|
      Cortex, Congestion, Multifocal       |                      2                                                   |      1  2.0|
      Cortex, Cytoplasmic Alteration, Focal|                                  2                                       |      2  2.5|
      Cortex, Degeneration, Fatty, Focal   |                               2                          3               |      6  2.2|
      Cortex, Degeneration, Fatty,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Focal           |    2                                                     2               |      5  2.2|
      Cortex, Hyperplasia, Multifocal      |                                                 2                        |      1  2.0|
      Cortex, Karyomegaly, Focal           |                                     3                                    |      1  3.0|
      Cortex, Necrosis, Multifocal         |                                                                          |      1  2.0|
      Medulla, Hyperplasia, Focal          |    2     2     2                 2           3        2  2               |     10  2.1|
      Medulla, Hyperplasia, Multifocal     |                                                             3            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +     +  +  +        +  +  +     +  +     +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +        +     +           +        +  +           +  +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  44        |
      Hyperplasia, Multifocal              |                                              2  2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst, Multiple        |                               X                                          |      1     |
      Pars Distalis, Hemorrhage, Focal     |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |    2              2        3                                             |      5  2.6|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                           3                              |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |             2     2                          2                           |      6  1.8|
      C-Cell, Hyperplasia, Multifocal      |       2                       2                                          |      3  2.0|
      Follicle, Cyst                       |                                           X  X           X               |      5     |
      Follicle, Cyst, Multiple             |          X                                                               |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                                  3                                       |      1  3.0|
      Bilateral, Inflammation, Multifocal, |                                                                          |            |
           Subacute                        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Necrotizing                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Hyperplasia, Multifocal, Nodular,    |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                 2                        |      3  2.7|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal, Necrotizing          |                                                                          |      1  4.0|
      Bilateral, Inflammation, Chronic     |                                                                          |            |
          Active, Multifocal               | 2  2  2  2  3  3        2  3     3  3     2  3     2        2  2     2  2|     36  2.3|
      Bilateral, Duct, Ectasia, Focal      |                                                                          |      1  3.0|
      Bilateral, Duct, Ectasia, Multifocal |                                              3                           |      2  2.5|
      Duct, Ectasia, Focal                 |          3                                                               |      3  3.0|
      Duct, Ectasia, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Multifocal    |                                        3                                 |      3  2.3|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  3.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                         2  2  2                                          |      3  2.0|
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Multifocal                  |                                                                          |      1  4.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia, Multifocal          |                         2                          2                     |      4  2.0|
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Atrophy, Chronic, Multifocal     |                                                                         4|      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Atrophy, Multifocal              | 3        4  3  4              4     4           3     4  3  4  4     4   |     20  3.8|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                      2           2                                       |      2  2.0|
      Interstitial Cell, Right,            |                                                                          |            |
          Hyperplasia, Multifocal          |       2                    2                                             |      3  2.0|
      Interstitial Cell, Left, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Interstitial Cell, Left, Hyperplasia,|                                                                          |            |
           Multifocal                      |    2                                                                     |      2  2.0|
      Seminiferous Tubule, Atrophy,        |                                                                          |            |
          Multifocal                       |                                                                          |      3  3.0|
      Seminiferous Tubule, Right, Atrophy, |                                                                          |            |
           Multifocal                      |    4                                         4                           |      3  4.0|
      Seminiferous Tubule, Left, Atrophy,  |                                                                          |            |
           Multifocal                      |       4           4        4                                             |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +        +  +        +  +                          +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Multifocal, Neutrophil  |                                                                2         |      1  2.0|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hypoplasia, Diffuse              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid, Multifocal       |                                                                          |      1  3.0|
      Mandibular, Cyst                     |                               X                                          |      1     |
      Mandibular, Depletion Lymphoid,      |                                                                          |            |
          Multifocal                       |                      2                                                   |      1  2.0|
      Mandibular, Hemorrhage, Multifocal   |                3                    2                 2                  |      5  2.2|
      Mandibular, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |       3                                                                  |      5  2.4|
      Mandibular, Hyperplasia, Multifocal, |                                                                          |            |
           Plasma Cell                     |                   3                                                  3  3|      5  3.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Multifocal, Plasma Cell         |                                                                          |      1  3.0|
      Mandibular, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Mandibular, Inflammation,            |                                                                          |            |
          Granulomatous, Multifocal        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage, Multifocal  |                      3                                      2     2      |      4  2.3|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous, Multifocal        |          2                                                               |      3  2.0|
      Mesenteric, Cyst, Multiple           |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |            |
           Multifocal                      |                      2                                                   |      1  2.0|
      Red Pulp, Fibrosis, Multifocal       |                   1                                                      |      1  1.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Multifocal        |                                           3                          3   |      5  3.0|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |                                        3                                 |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  I  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Depletion Lymphoid, Multifocal       | 2  2  2  2     2           2  3     2     3     2     3     3  3     2  2|     33  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  M  +  M  M  M  M  +  M  +  +  M  +  +  +  M  M  +  M  M  M  +|  22        |
      Acinus, Hyperplasia, Cystic,         |                                                                          |            |
          Multifocal                       |    2     2                    3        3     3  3  3                     |     12  2.5|
      Acinus, Hyperplasia, Multifocal      |                                     2                                   2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abdominal, Inflammation, Chronic,    |                                                                          |            |
           Focal, Suppurative              |                                                                          |      1  4.0|
      Abdominal, Subcutaneous Tissue,      |                                                                          |            |
          Edema, Multifocal, Subacute      |                                                                          |      1  3.0|
      Inguinal, Abscess                    |                                                                          |      1     |
      Inguinal, Subcutaneous Tissue,       |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femur, Osteopetrosis, Multifocal     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Medulla, Cerebrum, Hemorrhage, Acute,|                                                                          |            |
           Multifocal                      |                         2                                                |      1  2.0|
      Third Ventricle, Hemorrhage, Focal   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Acute, Diffuse           |                                                                          |      1  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interstitium, Inflammation,          |                                                                          |            |
          Multifocal, Subacute             |                2                                                         |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Granulomatous, Multifocal        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Degeneration, Multifocal             |                               3                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Focal, Subacute                 |                         2     2  3                       2           3   |      6  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Multifocal, Subacute            |       2                    2        2     2           2                  |     11  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Multifocal                      | 2     3  3  2  3  3     3  3     2  3     3  3  3  3  1  3  2        2   |     42  2.6|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Acute, Focal      |                   2                                                      |      1  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Acute, Multifocal |                                                                          |      1  2.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Multifocal, Suppurative          | 3                                                                        |      1  3.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Focal, Subacute   |                                                                          |      1  1.0|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Subacute                         |       2  3     3           2     2  2     2     2     2     2  3     2  2|     22  2.4|
      Submucosa, Respiratory Epithelium,   |                                                                          |            |
           Inflammation, Multifocal,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05052-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         2,4-DICHLOROPHENOL                                    Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 11:10:02  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|            |
                                           | 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10000                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    PPM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   2        |
      Lens, Cataract                       |                      2                                                   |      1  2.0|
      Retina, Atrophy, Multifocal          |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +        +  +     +     +  +     +  +        +         |  36        |
      Hyperplasia, Focal, Glandular        |    2                                                                     |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Inflammation, Multifocal, Subacute   |    2              2                                                      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Bilateral, Nephropathy, Chronic,     |                                                                          |            |
           Multifocal                      | 3  3  2  3  3  4  4  1  3  3  4  2  3  1  3  3  3     2  3  3  4  1  3  3|     48  2.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
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