National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1813

TDMS Study 05052-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/07/94   
EXP: 05052                   2,4-DICHLOROPHENOL                TIME: 20:46:29   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C55345   
CONT: N01-ES-38068                                             CAS: 120-83-2    
PATHOLOGIST: S. ESUTIS                       R. PERSING                         
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/07/94  
EXP: 05052                   2,4-DICHLOROPHENOL                TIME: 20:46:29  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C55345  
CONT: N01-ES-38068                                             CAS: 120-83-2   
PATHOLOGIST: S. ESUTIS                       R. PERSING                        

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      419   498   548   571   622   652   656   658   663   665                 |
 |      671   671   674   680   680   695   713                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   426   469   477   516   559   562   577   592   622                 |
 |      625   636   642   665   669   674   674   679   681   690                 |
 |      700   700   700   710   713                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10000   PPM                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      219   454   519   597   611   623   625   631   645   658                 |
 |      659   665   674   680   681   681   693   700                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  92.0  80.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0 100.0 100.0 100.0  98.0  92.0  90.0  82.0  72.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10000   PPM|   100.0 100.0  98.0  98.0  98.0  96.0  94.0  92.0  76.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            5000 PPM         10000   PPM   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            50.0%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.877          P=0.148          P=0.939       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       631.5            614.9            611.9         |
 |NATURAL DEATHS (C)      |       (19.0)           (18.4)           (27.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       694.5            670.9            685.6         |
 |(STANDARD ERROR)        |       ( 9.0)           (12.1)           (12.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      289   429   560   580   610   636   659   692   693   693                 |
 |      693   695   701   708   713   722                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      188   562   584   610   647   674   722                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      343   343   426   464   548   571   638   671   674   713                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                2,4-DICHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.0  98.0  96.0  96.0  92.0  86.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0 100.0  98.0  98.0  98.0  98.0  98.0  94.0  90.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0 100.0 100.0  96.0  96.0  92.0  92.0  88.0  86.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            2500 PPM         5000 PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%            86.0%            80.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.234N         P=0.066N         P=0.319N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       629.6            569.6            539.1         |
 |NATURAL DEATHS (C)      |       (29.7)           (66.8)           (43.7)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       696.5            705.8            690.2         |
 |(STANDARD ERROR)        |       (11.4)           (11.8)           (13.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         2,4-DICHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        5000 PPM         = 2
                                                        10000   PPM      = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                  3                              1
      |
      |                                    3                              12    3      1
      |                                                                    2    3 2    1   3   1
   95 +
      |                                                                           2 2      3   1  1    3
      |                                                                             2    2        1    3 31
      |
   90 +                                                                                  2      2        31    1
      |
      |                                                                                         22        33
      |                                                                                          2 2       33
P  85 +
E     |                                                                                            2  2     3 31 1
R     |                                                                                               2   2   33
C     |
E  80 +                                                                                                   22   3 11
N     |
T     |                                                                                                    22
      |                                                                                                     22   311
S  75 +
U     |                                                                                                      2   2 11
R     |                                                                                                          22
V     |
I  70 +                                                                                                           221 1
V     |
A     |                                                                                                             331 1
L     |                                                                                                              33 1 1
   65 +
      |                                                                                                            22 3   3
      |                                                                                                             22
      |
   60 +                                                                                                              22
      |
      |
      |
   55 +
      |                                                                                                               2 2
      |
      |
   50 +                                                                                                                 2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

                                                         2,4-DICHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        2500 PPM         = 2
                                                        5000 PPM         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                             2               1       3
      |
      |                               2               1                     1                    2
      |                                                       3            31                   12  2
   95 +
      |                                                                    3      3             1  12    2
P     |                                                                           3            3   1     1    2
E     |
R  90 +                                                                                        3  3      1  1 2    2
C     |
E     |                                                                                           3         13   1 2      2
N     |                                                                                                      3   13  1    2
T  85 +
      |                                                                                                           33
S     |                                                                                                            3    3
U     |
R  80 +                                                                                                                 3 3
V     |
I     |                                                                                                              11
V     |                                                                                                               11
A  75 +
L     |                                                                                                                11
      |
      |
   70 +                                                                                                                 1 1
      |
      |                                                                                                                   1
      |
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

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