TDMS Study 05053-02 Pathology Tables
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|
| 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + A + + + + + M + M + A + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + M + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Inflammation, Acute | 3 |
Necrosis | 2 |
Lymphoid Nodule, Hyperplasia | 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Basophilic Focus | X |
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 2 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 1 1 2|
Infarct | 3 |
Mineralization | |
Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Acute | 2 3 3 2 3 2 2|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + M + + + + + + + + + + +|
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 2 |
Forestomach, Angiectasis | 1 |
Forestomach, Hyperkeratosis | 1 1 2|
Forestomach, Inflammation, Chronic | |
Active | 1 1|
Glandular, Hyperplasia | 1 |
Glandular, Inflammation, Chronic | |
Active | 1 1 1 1 |
Glandular, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hematopoietic Cell Proliferation | 1 1 1 1 1|
Capsule, Hyperplasia | 1 2 2 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1|
Medulla, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|
| 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + M + M M + + M M + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + M + + + + M +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 1 1 2 1 1 3 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 1 1 1 |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M M |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + M + + + + + +|
Abscess | 2 3 4 3|
Cyst | X X X X X X |
Hemorrhage | |
Mineralization | 1 |
Bilateral, Abscess | 4 4 4 4 4 4 |
__________________________________________________________________________|
Oviduct | |
Inflammation, Acute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | 2 |
Inflammation, Acute | 1 1 1 1 1 2 1|
Necrosis | |
Endometrium, Hyperplasia | 3 2 1 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + +|
Inguinal, Hematopoietic Cell | |
Proliferation | 2 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Lymphoid | 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Necrosis | |
Mandibular, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|
| 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 1|
Mandibular, Inflammation, Acute | 3 |
Mediastinal, Angiectasis | 2 |
Mediastinal, Bacterium | X |
Mediastinal, Hematopoietic Cell | |
Proliferation | 1 1 1 1 1 1 |
Mediastinal, Hyperplasia, Plasma Cell| 1 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 2|
Mediastinal, Inflammation, Acute | 3 3 2|
Mediastinal, Necrosis | 2 3 |
Mesenteric, Angiectasis | 1 1 1 1 1 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 2 1 1 3 2 2 2 1 |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Hyperplasia, Lymphoid | 4 |
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Infiltration Cellular, | |
Plasma Cell | 2 |
Renal, Angiectasis | |
Renal, Hematopoietic Cell | |
Proliferation | 2 1 2 |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Plasma Cell | 3 3 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | 3 1 1 2 3 1 2 3 2 1 2 2 3 3 2 3 3 2 2 3|
Hyperplasia, Lymphoid | 3 |
Necrosis | 1 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + M + M M + M + + + + + + + + + + + M + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + M M M M + + + M M + M M M M M M + M M|
Galactocele | |
__________________________________________________________________________|
Skin | + M + + + + M + + + + + M + + + M M + + + + + +|
Hyperkeratosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Metaplasia, | |
Osseous | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|
| 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 1 1|
Alveolar Epithelium, Hyperplasia | 1 |
Pleura, Inflammation, Acute | 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 1|
Metaplasia, Osseous | |
Cortex, Mineralization | |
Glomerulus, Inflammation, Acute | 2 2 1 1 1|
Papilla, Mineralization | 1 1 1 1 1 |
Papilla, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9| |
| 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + + M + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | M + + + M + M + + + + + + + + + + + + + + A M + +| 38 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoid Nodule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Necrosis | | 1 2.0|
Lymphoid Nodule, Hyperplasia | 1 1 2 1 1 1 1 | 16 1.1|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 1 2.0|
Basophilic Focus | | 1 |
Fatty Change, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 1 2 1 3 1 2 1 1 1 2 1| 32 1.5|
Infarct | | 1 3.0|
Mineralization | 1 | 1 1.0|
Necrosis | 2 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 16 |
Inflammation, Acute | 2 2 2 2 1 3 2 | 14 2.2|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
Necrosis, Coagulative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Forestomach, Acanthosis | 2 | 2 2.0|
Forestomach, Angiectasis | | 1 1.0|
Forestomach, Hyperkeratosis | 1 1 1 | 6 1.2|
Forestomach, Inflammation, Chronic | | |
Active | 2 2 | 4 1.5|
Glandular, Hyperplasia | | 1 1.0|
Glandular, Inflammation, Chronic | | |
Active | 1 | 5 1.0|
Glandular, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9| |
| 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 |
Hematopoietic Cell Proliferation | 1 1 1 3 | 9 1.2|
Capsule, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 2 2 1 1 2 1 1 2| 38 1.3|
Medulla, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + M M + + + + M + M M + M + M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + M + + + + + +| 44 |
Pars Distalis, Angiectasis | 2 2 1 | 4 1.8|
Pars Distalis, Hyperplasia | 1 1 1 2 2 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | 1 | 4 1.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + M + + + M + + + + + + + + + +| 45 |
Abscess | 4 4 2 3 1 4 3 4 2 | 13 3.0|
Cyst | X X X X X| 11 |
Hemorrhage | 2 | 1 2.0|
Mineralization | | 1 1.0|
Bilateral, Abscess | 3 4 4 4 | 10 3.9|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 3 3 | 2 3.0|
Angiectasis | | 1 2.0|
Inflammation, Acute | 1 1 1 1 1 2 2 | 14 1.2|
Necrosis | 2 | 1 2.0|
Endometrium, Hyperplasia | 1 2 2 2 3 1 1 2 1 2 2 | 20 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9| |
| 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + M + M + + + + + + + + + + + + + + M + + + M| 44 |
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | | 1 4.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Lumbar, Necrosis | 2 | 1 2.0|
Mandibular, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
Mandibular, Inflammation, Acute | | 1 3.0|
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Bacterium | | 1 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | 1 1 | 8 1.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 3 1.7|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 2 | 4 2.3|
Mediastinal, Inflammation, Acute | | 3 2.7|
Mediastinal, Necrosis | 3 1 | 4 2.3|
Mesenteric, Angiectasis | 1 1 | 7 1.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 1 2 3 1 2 2 | 16 1.8|
Mesenteric, Hemorrhage | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 4.0|
Mesenteric, Hyperplasia, Plasma Cell | 1 | 2 1.5|
Mesenteric, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Renal, Angiectasis | 1 | 1 1.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 3 1.7|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hyperplasia, Plasma Cell | | 2 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | 3 1 3 2 2 3 3 2 3 4 1 1 2 1 3 2 1 3 2 2 3 3 1| 43 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9| |
| 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 1 1 | 4 1.5|
Necrosis | 2 | 2 1.5|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + M + + M + + + M M + + + M| 37 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M + M M M M M + + + M M + M + M + + M M M M| 17 |
Galactocele | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + M + + + M + + + + + + M + M + + + + + + + +| 40 |
Hyperkeratosis | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Subcutaneous Tissue, Metaplasia, | | |
Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Joint, Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thalamus, Mineralization | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bacterium | X | 2 |
Inflammation, Acute | 2 1 | 4 1.3|
Inflammation, Chronic Active | 1 1 | 4 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Pleura, Inflammation, Acute | 1 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| |
DAY ON TEST | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9| |
| 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 2 | 7 1.3|
Metaplasia, Osseous | 1 | 1 1.0|
Cortex, Mineralization | 1 | 1 1.0|
Glomerulus, Inflammation, Acute | | 5 1.4|
Papilla, Mineralization | | 5 1.0|
Papilla, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|
| 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + A A + + + A M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + |
Mineralization | 1 |
Necrosis | 3 |
Epithelium, Hyperplasia | 1 |
Lymphoid Nodule, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 1 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Necrosis | 1 1 |
Pigmentation | 1 1 1|
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Inflammation, Acute | 2 1 2 2 3 2 2 1 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
Forestomach, Acanthosis | 1 2 2 |
Forestomach, Hyperkeratosis | 1 1 2 1 1 2 |
Forestomach, Inflammation, Chronic | |
Active | 1 1|
Glandular, Hyperplasia | 1 1 |
Glandular, Inflammation, Chronic | |
Active | 1 1 |
Glandular, Necrosis | 1 |
Glandular, Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Cardiomyopathy | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 1 1 1 |
Capsule, Hyperplasia | 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + M + + + M |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + M + + + + + + |
Pars Distalis, Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|
| 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 1 1 1 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 |
Follicular Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Abscess | 3 4 4 2 4 4 4 4 3 |
Cyst | |
Degeneration, Cystic | 3 |
Mineralization | 2 |
Pigmentation | |
Bilateral, Abscess | 4 4 3 4 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Abscess | |
Angiectasis | |
Inflammation, Acute | 1 2 2 1 2 |
Endometrium, Hyperplasia | 2 2 1 2 1 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Plasma Cell | |
Lumbar, Hematopoietic Cell | |
Proliferation | 1 |
Lumbar, Hyperplasia, Plasma Cell | 2 |
Lumbar, Necrosis | 2 |
Mandibular, Hematopoietic Cell | |
Proliferation | 2 2 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 2 2 1 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Necrosis | 2 2 |
Mesenteric, Angiectasis | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 2 2 2 |
Mesenteric, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|
| 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hyperplasia, Plasma Cell | |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2 |
Renal, Hematopoietic Cell | |
Proliferation | 1 1 |
Renal, Hyperplasia, Plasma Cell | 2 2 |
Renal, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 1 3 2 2 3 2 3 3 3 2 1 3 3 2|
Hemorrhage | 2 |
__________________________________________________________________________|
Thymus | M M M + + + + M M + + |
Atrophy | 1 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Bacterium | X X X |
Edema | |
Inflammation, Chronic Active | 2 |
Pleura, Inflammation, Acute | 2 3 2 2 1 2 |
__________________________________________________________________________|
Nose | + M + + M + + M M + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|
DAY ON TEST | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|
| 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Necrosis | |
Cortex, Mineralization | |
Glomerulus, Inflammation, Acute | 1 2 1 |
Papilla, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | M M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4| |
DAY ON TEST | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9| |
| 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + M + + M + + + M + + M| 36 |
__________________________________________________________________________|____________|
Gallbladder | + M M + + + + A + A M + A +| 16 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + A + + + M + + A +| 22 |
Mineralization | | 1 1.0|
Necrosis | | 1 3.0|
Epithelium, Hyperplasia | | 1 1.0|
Lymphoid Nodule, Hyperplasia | 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Fatty Change, Diffuse | 2 1 | 2 1.5|
Fatty Change, Focal | 1 1 | 7 1.3|
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 | 34 1.1|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | 1 1 | 4 1.0|
Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 19 |
Inflammation, Acute | 2 2 1 3 2 2 4 2 2 | 19 2.1|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + M + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + M + + + +| 24 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Forestomach, Acanthosis | | 3 1.7|
Forestomach, Hyperkeratosis | 1 1 2 1 1 1 1 | 13 1.2|
Forestomach, Inflammation, Chronic | | |
Active | | 2 1.0|
Glandular, Hyperplasia | 1 1 | 4 1.0|
Glandular, Inflammation, Chronic | | |
Active | 1 1 1| 5 1.0|
Glandular, Necrosis | 1 2| 3 1.3|
Glandular, Pigmentation | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + +| 26 |
Cardiomyopathy | 1 1 | 2 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + M| 26 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4| |
DAY ON TEST | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9| |
| 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 2 1 | 17 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + M + + + + + + M +| 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + M M + + + + M + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + M + + M + + + + + +| 27 |
Pars Distalis, Angiectasis | 2 2 1 2 | 5 1.6|
Pars Distalis, Hyperplasia | 1 3 1 | 7 1.4|
Pars Distalis, Pigmentation | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Follicular Cell, Hyperplasia, Focal | 1 1 | 3 1.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + +| 36 |
Abscess | 3 4 4 4 3 4 4 | 16 3.6|
Cyst | X X X X X | 5 |
Degeneration, Cystic | | 1 3.0|
Mineralization | 1 | 2 1.5|
Pigmentation | 2 | 1 2.0|
Bilateral, Abscess | 4 4 4 3 4 4 4 4 | 15 3.9|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + +| 39 |
Abscess | 3 | 1 3.0|
Angiectasis | 1 | 1 1.0|
Inflammation, Acute | 1 2 1 1 2 1 1 | 12 1.4|
Endometrium, Hyperplasia | 2 2 1 1 2 1 1 2 1| 19 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + M + + + + + M| 32 |
Axillary, Hyperplasia, Plasma Cell | 1 | 1 1.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | 1 | 2 1.0|
Lumbar, Hyperplasia, Plasma Cell | 2 2 1 | 4 1.8|
Lumbar, Necrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4| |
DAY ON TEST | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9| |
| 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Hematopoietic Cell | | |
Proliferation | 2 2 1 1 | 7 1.7|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 2 | 4 1.8|
Mediastinal, Hyperplasia, Plasma Cell| 2 2 2 3 | 4 2.3|
Mediastinal, Necrosis | 2 | 3 2.0|
Mesenteric, Angiectasis | 2 2 1 | 3 1.7|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 2 2 2 | 9 2.1|
Mesenteric, Hemorrhage | | 1 2.0|
Mesenteric, Hyperplasia, Plasma Cell | 2 2 | 2 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 | 2 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 1 1 | 4 1.0|
Renal, Hyperplasia, Plasma Cell | 3 2 3 2 | 6 2.3|
Renal, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + +| 35 |
Hematopoietic Cell Proliferation | 2 3 2 2 2 3 3 3 3 3 2 3 3 4 3 3 | 32 2.6|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M M + M + M + + + + M M| 14 |
Atrophy | | 1 1.0|
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M + M M M + M M + + +| 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 25 |
Subcutaneous Tissue, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + +| 25 |
Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + +| 27 |
Bacterium | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4| |
DAY ON TEST | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9| |
| 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 | 4 1.3|
Pleura, Inflammation, Acute | 2 3 1 1 2 | 11 1.9|
__________________________________________________________________________|____________|
Nose | M + + + + + M + + M + M + M| 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 32 |
Inflammation, Acute | 3 | 3 2.7|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 2 | 4 1.3|
Necrosis | 2 | 1 2.0|
Cortex, Mineralization | 1 | 1 1.0|
Glomerulus, Inflammation, Acute | 1 2 2 | 6 1.5|
Papilla, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | A + A + + + + M + M M + M +| 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|
DAY ON TEST | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|
| 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A M + + + M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 1 1 2 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Fatty Change, Diffuse | 1 2 |
Fatty Change, Focal | 2 1 1 1 2 1 1 2 2 2 1|
Hematopoietic Cell Proliferation | 2 1 2 2 1 1 1 1 2 2 2 1 1 1 1 1 1 1 1 |
Infarct | |
Inflammation, Chronic Active | |
Necrosis | 1 1 1 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Inflammation, Acute | 2 2 1 2 2 1 4 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 1 2 |
Forestomach, Hyperkeratosis | 1 1 2 |
Forestomach, Inflammation, Chronic | |
Active | 2 |
Glandular, Ectopic Tissue | |
Glandular, Hyperplasia | 1 1 |
Glandular, Inflammation, Chronic | |
Active | 1 |
Glandular, Mineralization | |
Glandular, Necrosis | 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Mineralization | |
Artery, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + M + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 |
Capsule, Hyperplasia | 1 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|
DAY ON TEST | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|
| 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Medulla, Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + M + M M M + + + + + + M M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 3 1 2 2 |
Pars Intermedia, Hyperplasia | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + M M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4 4 4 3 |
Angiectasis | |
Cyst | X X |
Pigmentation | |
Bilateral, Abscess | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Abscess | 2 2 |
Hemorrhage | 2 |
Inflammation, Acute | 1 1 2 2 |
Endometrium, Hyperplasia | 1 2 1 1 1 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + M + + + + + + + + +|
Lumbar, Angiectasis | |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Lumbar, Hyperplasia, Plasma Cell | 1 3 |
Mandibular, Angiectasis | 3 |
Mandibular, Hematopoietic Cell | |
Proliferation | 1 1 1 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 1 2 2 1 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|
DAY ON TEST | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|
| 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Necrosis | 2 2 |
Mesenteric, Angiectasis | 2 1 1|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 1 1 1 1 |
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Renal, Hematopoietic Cell | |
Proliferation | 2 1 |
Renal, Hyperplasia, Plasma Cell | 3 1 |
Renal, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 3 2 1 2 3 2 3 3 3 2 1 1 1 2 2 1 1 3 1 2 2|
Hyperplasia, Lymphoid | 1 |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | M M M + + + + M + + + M + + M + + + M + + + + + +|
Atrophy | 2 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M + M M + M M M + M M M M M M M M + M|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + M + M + + + + + M +|
Necrosis | 2|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | X |
Edema | |
Hemorrhage | 1 1 1 |
Inflammation, Chronic Active | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Pleura, Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Nose | + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|
DAY ON TEST | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|
| 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 1 1 1 |
Pigmentation | |
Cortex, Mineralization | |
Glomerulus, Inflammation, Acute | 1 2 |
Papilla, Mineralization | 1 |
Papilla, Necrosis | 1 |
Renal Tubule, Casts | 1 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| |
DAY ON TEST | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3| |
| 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | A A + + + + A + M M + A A + + + + + + + + + A M +| 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoid Nodule, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Lymphoid Nodule, Hyperplasia | 1 2 1 1 1 1 1 1 1| 15 1.2|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 1 |
Fatty Change, Diffuse | 2 2 | 4 1.8|
Fatty Change, Focal | 1 1 1 1 2 1 2 1 1| 20 1.4|
Hematopoietic Cell Proliferation | 1 2 1 1 1 3 3 2 2 2 1 1 1 1 1 2 1| 36 1.4|
Infarct | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Necrosis | 1 1 1 1 | 8 1.0|
Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 19 |
Inflammation, Acute | 2 3 2 3 2 3 1 2 3 3 | 19 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + M + +| 47 |
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + M + + + + M + + + + + M M + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Acanthosis | | 2 1.5|
Forestomach, Hyperkeratosis | 1 1 1 | 6 1.2|
Forestomach, Inflammation, Chronic | | |
Active | | 1 2.0|
Glandular, Ectopic Tissue | X | 1 |
Glandular, Hyperplasia | 1 1 | 4 1.0|
Glandular, Inflammation, Chronic | | |
Active | 1 1 | 3 1.0|
Glandular, Mineralization | 1 | 1 1.0|
Glandular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 2 1.0|
Mineralization | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| |
DAY ON TEST | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3| |
| 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 8 1.0|
Capsule, Hyperplasia | 1 1 1 2 1 2 1 1 1 1 2 2 2 1 2 1 1 1 3| 38 1.3|
Medulla, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M + + M + M + M + + + + + M + M M M M + +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + M + + + + + + + + + + M +| 46 |
Pars Distalis, Angiectasis | | 2 1.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 1 2 | 13 1.5|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + M M + + + + + + + + + + + + + + + M + + + + +| 47 |
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 1 1 2 1 1 | 17 1.1|
Follicular Cell, Hyperplasia, | | |
Multifocal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M M M M M M| 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Abscess | 4 4 4 2 4 4 4 4 4 4 | 19 3.8|
Angiectasis | 2 | 1 2.0|
Cyst | X X | 4 |
Pigmentation | 2 | 1 2.0|
Bilateral, Abscess | 4 4 4 3 4 | 7 3.9|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 2 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Acute | 2 1 2 1 1 1 2 1 | 12 1.4|
Endometrium, Hyperplasia | 2 1 1 2 1 2 2 2 2 2 2| 22 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + M + + + + + M + + + M + +| 45 |
Lumbar, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| |
DAY ON TEST | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3| |
| 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | 1 | 3 1.7|
Mandibular, Angiectasis | | 1 3.0|
Mandibular, Hematopoietic Cell | | |
Proliferation | 3 2 | 5 1.6|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 1 2 1 | 7 1.4|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 2 2 2 2 | 10 2.3|
Mediastinal, Necrosis | 2 1 1 | 5 1.6|
Mesenteric, Angiectasis | 2 1 | 5 1.4|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 3 2 2 2 2 | 11 1.9|
Mesenteric, Hyperplasia, Plasma Cell | 1 | 2 1.5|
Renal, Hematopoietic Cell | | |
Proliferation | 2 | 3 1.7|
Renal, Hyperplasia, Plasma Cell | 2 | 3 2.0|
Renal, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 1 2 3 3 3 2 3 4 1 3 2 3 1 1 1 3 1 2 1 1 3 3 1| 48 2.1|
Hyperplasia, Lymphoid | 1 2 2 3 | 5 1.8|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + M M M + M M + + + + M + + + + + +| 35 |
Atrophy | | 2 1.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M + M M M M M + + + M M M + M M M +| 13 |
__________________________________________________________________________|____________|
Skin | + + + + M + + M + + + + + + + + + + + + + + + + +| 44 |
Necrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7| |
DAY ON TEST | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3| |
| 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 2 | 1 2.0|
Bacterium | X X X X | 5 |
Edema | 1 | 1 1.0|
Hemorrhage | 1 1 1 | 6 1.0|
Inflammation, Chronic Active | 1 1 | 4 1.3|
Alveolar Epithelium, Hyperplasia | | 3 1.0|
Pleura, Inflammation, Acute | 1 2 1 1 3 1 2 | 9 1.4|
__________________________________________________________________________|____________|
Nose | + M + + + + M + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Glomerulosclerosis | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 11 1.0|
Pigmentation | 1 | 1 1.0|
Cortex, Mineralization | 1 1 | 2 1.0|
Glomerulus, Inflammation, Acute | 2 1 1 | 5 1.4|
Papilla, Mineralization | 1 1 | 3 1.0|
Papilla, Necrosis | | 1 1.0|
Renal Tubule, Casts | | 1 1.0|
Renal Tubule, Regeneration | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|
| 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + M + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + M + + M + + + + + + + + + A|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Ileum, Epithelium, Hyperplasia | |
Lymphoid Nodule, Hyperplasia | 2 1 1 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Fatty Change, Focal | 2 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1|
Infarct | 1 |
Mineralization | 1 1 |
Necrosis | 1 1 2 1 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | |
Inflammation, Chronic Active | |
Forestomach, Acanthosis | 2 1 |
Forestomach, Fibrosis | 1 |
Forestomach, Hyperkeratosis | 1 2 |
Forestomach, Inflammation, Chronic | |
Active | 1 |
Forestomach, Ulcer | 1 1 |
Glandular, Inflammation, Chronic | |
Active | 1 |
Glandular, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 1 2 1 2 1 1 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|
| 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Hyperplasia | 1 |
Cortex, Hypertrophy, Focal | 1 |
Medulla, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M M M M M M + M M + M + M + M + M M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + + + + + + M +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + M + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Dilatation | |
Inflammation, Chronic Active | 1 1 1 |
Necrosis | |
__________________________________________________________________________|
Prostate | + + M + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 1 1|
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M +|
Lumbar, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Angiectasis | 1 1 1 1 1 2 1 2 3 2|
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 1 1 1 1 3 1 1|
Mesenteric, Necrosis | |
Renal, Necrosis | |
Thoracic, Angiectasis | 2 |
Thoracic, Necrosis | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|
| 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 |
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 2 1 1 1 1 1 1 2 1 2 2 1 1 3|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + + + + M M M + M + + M + M + + + + + M + + M|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Necrosis | 3|
Subcutaneous Tissue, Metaplasia, | |
Osseous | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 1 2 2 2 2 1 2 2 1 2 2 1 1 1 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor | |
Hemorrhage | 2 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + M + + + + + + + + + M + + M + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
Embolus Tumor | |
Inflammation, Chronic Active | 2 2 |
Cortex, Mineralization | 2 1 1 1 1 1 |
Papilla, Mineralization | 1 |
Renal Tubule, Casts | 1 2 |
Renal Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|
| 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4| |
| 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic Active | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Nodule, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Ileum, Epithelium, Hyperplasia | 1 | 1 1.0|
Lymphoid Nodule, Hyperplasia | 1 2 1 1 1 1 1 3 2 1 2 2 1 1 1| 26 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Fatty Change, Focal | 1 1 1 1 | 7 1.1|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1| 20 1.0|
Infarct | | 1 1.0|
Mineralization | 1 | 3 1.0|
Necrosis | 1 1 2 1 1| 10 1.3|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Glandular | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Forestomach, Acanthosis | 1 1| 4 1.3|
Forestomach, Fibrosis | | 1 1.0|
Forestomach, Hyperkeratosis | 2 2 1| 5 1.6|
Forestomach, Inflammation, Chronic | | |
Active | | 1 1.0|
Forestomach, Ulcer | | 2 1.0|
Glandular, Inflammation, Chronic | | |
Active | 1 1 1 | 4 1.0|
Glandular, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4| |
| 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 1 1 1 1 2 1 1 3 1 1 2 2 2 1 1 | 31 1.4|
Cortex, Hyperplasia | | 1 1.0|
Cortex, Hypertrophy, Focal | | 1 1.0|
Medulla, Hyperplasia | 2 1 1 1 1| 8 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + M + + + + M + + M + + M + M M M M +| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +| 45 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 | 3 1.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Preputial Gland | + + +| 7 |
Dilatation | 1 | 1 1.0|
Inflammation, Chronic Active | 3 1| 5 1.4|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + M| 46 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 1 1 1 1 | 7 1.0|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + M + + + + + + + + + + + + M| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4| |
| 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Plasma Cell | | 1 2.0|
Mesenteric, Angiectasis | 1 1 1 2 3 2 1 2 1 3 1 1 | 22 1.5|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 2 1 1 1 1 1 | 15 1.3|
Mesenteric, Necrosis | 2 | 1 2.0|
Renal, Necrosis | 1 | 1 1.0|
Thoracic, Angiectasis | | 1 2.0|
Thoracic, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 1 2 1 1 2 3 1 3 1 1 1 2 1 2 1 1 1 1| 40 1.4|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + M + + M + + + M + + + + + M + + +| 35 |
Atrophy | 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Bacterium | X | 1 |
Necrosis | 3 2 3 | 4 2.8|
Subcutaneous Tissue, Metaplasia, | | |
Osseous | 2 | 1 2.0|
Subcutaneous Tissue, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Tarsal, Hyperostosis | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 2 2| 35 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Tumor | X | 1 |
Hemorrhage | 1 1 1 1 | 7 1.1|
Infiltration Cellular, Histiocyte | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4| |
| 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 4 |
Embolus Tumor | X | 1 |
Inflammation, Chronic Active | 2 | 3 2.0|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.1|
Papilla, Mineralization | | 1 1.0|
Renal Tubule, Casts | 2 1 1| 5 1.4|
Renal Tubule, Degeneration | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 18 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Calculus Micro Observation Only | X X | 2 |
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.05 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + |
__________________________________________________________________________|
Gallbladder | + + + A |
__________________________________________________________________________|
Intestine Large | + + + + + |
Circumanal Gland, Inflammation, Acute| 1 |
Lymphoid Nodule, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small | + + + A |
Duodenum, Fibrosis | 2 |
Duodenum, Hyperplasia | 2 |
Duodenum, Inflammation, Chronic | |
Active | 2 |
Duodenum, Necrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 2 1 1 |
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | 2 |
Mineralization | 1 |
Necrosis | 2 2 1 2 |
Regeneration | 3 |
Thrombosis | 1 |
__________________________________________________________________________|
Mesentery | |
Abscess | |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 1 |
Forestomach, Acanthosis | 2 |
Forestomach, Fibrosis | 1 |
Forestomach, Hyperkeratosis | 1 2 |
Forestomach, Inflammation, Chronic | |
Active | 2 |
Forestomach, Mineralization | |
Forestomach, Ulcer | 1 |
Glandular, Hyperplasia | 1 1 |
Glandular, Inflammation, Chronic | |
Active | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Pericardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.05 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + +|
Capsule, Hyperplasia | 2 1 1 1 1|
Cortex, Hypertrophy | 1 |
Medulla, Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
Abscess | 2 |
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | X |
Inflammation, Chronic Active | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Prostate | + + + + |
Hemorrhage | |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + |
Spermatocele | X |
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + M + + + +|
Lumbar, Hyperplasia, Plasma Cell | |
Mesenteric, Angiectasis | 2 1 1 2 1|
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 1 2 1 1|
Pancreatic, Hematopoietic Cell | |
Proliferation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Angiectasis | 1 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 1 3 1 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.05 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Mast Cell | 1 |
__________________________________________________________________________|
Thymus | M + + + |
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Bacterium | X |
Hemorrhage | |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Necrosis | 2 2 |
Prepuce, Inflammation, Chronic Active| |
Sebaceous Gland, Hyperplasia | 2 |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 2 2 2 2 1 2 1 2 1 2 2 1 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 3 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic Active | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.05 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Mineralization | |
Renal Tubule, Casts | |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + A + + + |
Angiectasis | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3| |
| 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.05 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large | + + | 7 |
Circumanal Gland, Inflammation, Acute| | 1 1.0|
Lymphoid Nodule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + | 6 |
Duodenum, Fibrosis | | 1 2.0|
Duodenum, Hyperplasia | | 1 2.0|
Duodenum, Inflammation, Chronic | | |
Active | | 1 2.0|
Duodenum, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Cyst | 1 | 1 1.0|
Fatty Change, Diffuse | 2 | 1 2.0|
Fatty Change, Focal | 2 | 5 1.6|
Hematopoietic Cell Proliferation | 1 1 1 | 5 1.0|
Hemorrhage | | 1 2.0|
Mineralization | 1 1 | 3 1.0|
Necrosis | 3 2 2 1 | 8 1.9|
Regeneration | | 1 3.0|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Abscess | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 8 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Glandular | | 1 1.0|
Forestomach, Acanthosis | 2 2 | 3 2.0|
Forestomach, Fibrosis | | 1 1.0|
Forestomach, Hyperkeratosis | 1 2 2 | 5 1.6|
Forestomach, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Forestomach, Mineralization | 1 | 1 1.0|
Forestomach, Ulcer | 2 | 2 1.5|
Glandular, Hyperplasia | 1 1 | 4 1.0|
Glandular, Inflammation, Chronic | | |
Active | 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3| |
| 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.05 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 6 |
Pericardium, Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 9 |
Capsule, Hyperplasia | 1 | 6 1.2|
Cortex, Hypertrophy | | 1 1.0|
Medulla, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M | 6 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 7 |
Abscess | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 9 |
Cyst | X X | 3 |
Inflammation, Chronic Active | 1 | 2 1.0|
Necrosis | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Prostate | + + | 6 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 10 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + | 9 |
Spermatocele | | 1 |
Seminiferous Tubule, Atrophy | | 1 1.0|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3| |
| 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.05 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + +| 15 |
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mesenteric, Angiectasis | 1 2 2 2 3| 10 1.7|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 1 2 2 2 1| 10 1.4|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 18 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 2 2 3 2 2 2 | 15 1.7|
Hyperplasia, Mast Cell | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + | 6 |
Atrophy | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 23 |
Bacterium | X X | 3 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 1| 2 1.5|
Necrosis | 3 3 2 2 2 2 | 8 2.3|
Prepuce, Inflammation, Chronic Active| 1 | 1 1.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Fibrosis | 2 1 1 | 3 1.3|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Joint, Tarsal, Hyperostosis | 1 2 1 1 1 1 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2| 40 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3| |
| 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.05 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 1 1 1 | 4 1.0|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Chronic Active | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
Bronchiole, Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 20 |
Cyst | X | 1 |
Inflammation, Chronic Active | 2 | 4 1.5|
Cortex, Mineralization | 1 1 | 2 1.0|
Renal Tubule, Casts | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 7 |
Angiectasis | | 1 2.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M + + + + + M + M M + + + + + + + + + + M +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Lymphoid Nodule, Necrosis | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change, Focal | 1 1 2 1 1 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 |
Hemorrhage | 1 |
Mineralization | 1 |
Necrosis | 2 1 1 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 2 2 2 2 2 |
Forestomach, Cyst Epithelial | |
Inclusion, Multiple | |
Forestomach, Hyperkeratosis | 1 1 2 1 1 |
Forestomach, Inflammation, Chronic | |
Active | 2 2 |
Forestomach, Ulcer | 1 2 |
Glandular, Cyst | X |
Glandular, Dysplasia | 1 |
Glandular, Hyperplasia | 2 1 2 |
Glandular, Inflammation, Chronic | |
Active | 1 2 1 1 1 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + M + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Cortex, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Hypertrophy, Diffuse | 4 |
Cortex, Hypertrophy | 1 1 |
Medulla, Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + M M + + + M + M + M M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + + + + M + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic Active | 1 1 |
Necrosis | 3 2 |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + M + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 1 1 |
Seminiferous Tubule, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node | M + + + + + + + + M + + + + + + + + + + + + + + +|
Lumbar, Angiectasis | |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | |
Mesenteric, Angiectasis | 1 1 1 1 1 2 2 2 1 1 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 1 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + + + + + + M M + M M + + + + + + + + M + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hemorrhage | |
Necrosis | 2 |
Prepuce, Acanthosis | |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Necrosis | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 1 2 2 1 2 1 2 1 2 1 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Mineralization | |
Thalamus, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Fungus | |
Hemorrhage | 1 1 1 1 1|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Abscess | |
Fibrosis | |
Fungus | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 2 |
Cortex, Mineralization | 1 1 1 1 1 1 |
Papilla, Mineralization | 1 |
Papilla, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Casts | 1 3 |
Renal Tubule, Degeneration | 1|
Renal Tubule, Regeneration | 1 1 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5| |
DAY ON TEST | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6| |
| 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + M +| 47 |
__________________________________________________________________________|____________|
Gallbladder | M A + M M M + M + + M M M + + + M M + + M + + M M| 30 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Lymphoid Nodule, Hyperplasia | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + M + + M + + M +| 46 |
Lymphoid Nodule, Hyperplasia | 1 1 1 2 1 1 1 | 21 1.1|
Lymphoid Nodule, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Fatty Change, Focal | 1 | 7 1.1|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 3 1 2 1 1 1 1 | 14 1.2|
Hemorrhage | | 1 1.0|
Mineralization | 1 1 | 3 1.0|
Necrosis | 1 2 2 2 1 1 2 1 1| 12 1.4|
Bile Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + M +| 48 |
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + M +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Forestomach, Acanthosis | 2 | 6 2.0|
Forestomach, Cyst Epithelial | | |
Inclusion, Multiple | X | 1 |
Forestomach, Hyperkeratosis | 2 1 | 7 1.3|
Forestomach, Inflammation, Chronic | | |
Active | | 2 2.0|
Forestomach, Ulcer | | 2 1.5|
Glandular, Cyst | | 1 |
Glandular, Dysplasia | | 1 1.0|
Glandular, Hyperplasia | 1 1 2 | 6 1.5|
Glandular, Inflammation, Chronic | | |
Active | 2 1 | 8 1.4|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5| |
DAY ON TEST | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6| |
| 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 | 30 1.1|
Cortex, Hyperplasia | 1 1 | 2 1.0|
Cortex, Hypertrophy, Diffuse | | 1 4.0|
Cortex, Hypertrophy | | 2 1.0|
Medulla, Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + M +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + M M + M M + + M + M + M M M + M + M M +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + M M + + + M M + + + + + + M + + M +| 40 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M + M + + + + + + + + + + M + + M +| 46 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + +| 10 |
Inflammation, Chronic Active | 1 1 2 | 5 1.2|
Necrosis | 2 2 1| 5 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + + + + + + + + + + + M + + M +| 45 |
Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Seminiferous Tubule, Atrophy | 1 1 1 | 6 1.0|
Seminiferous Tubule, Mineralization | 1| 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + M + + + + + + + + M M + + M +| 43 |
Lumbar, Angiectasis | 1| 1 1.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | 1 | 1 1.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Mesenteric, Angiectasis | 1 2 1 1 | 14 1.3|
Mesenteric, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5| |
DAY ON TEST | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6| |
| 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation | 2 1 3 2 | 10 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Atrophy | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 2 1 1 2 1 3 4 2 1 2 3 1 2 2 1 1 3 1 | 38 1.4|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M M + + M M + M M + + + + M + M + M + M M M + M M| 30 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Bacterium | X X | 2 |
Hemorrhage | 1 | 1 1.0|
Necrosis | 2 3 2 2 2 2 2 | 8 2.1|
Prepuce, Acanthosis | 2 | 1 2.0|
Prepuce, Inflammation, Chronic Active| 2 | 1 2.0|
Prepuce, Necrosis | 1 2 | 2 1.5|
Subcutaneous Tissue, Fibrosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Joint, Tarsal, Hyperostosis | 1 1 2 1 1 1 1 2 2 2 1 1 | 27 1.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + M + + M +| 48 |
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 | 1 1.0|
Thalamus, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Abscess | 2 | 1 2.0|
Fungus | X | 1 |
Hemorrhage | 1 1 | 7 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + M + + M +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05053-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:53:04
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5| |
DAY ON TEST | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6| |
| 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Abscess | 3 | 1 3.0|
Fibrosis | 3 | 1 3.0|
Fungus | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Abscess | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 2 1.5|
Cortex, Mineralization | 1 1 2 2 | 10 1.2|
Papilla, Mineralization | | 1 1.0|
Papilla, Necrosis | 1 | 1 1.0|
Renal Tubule, Casts | 1 1 | 4 1.5|
Renal Tubule, Degeneration | | 1 1.0|
Renal Tubule, Regeneration | 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + M +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
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---------- END OF REPORT ----------
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