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TDMS Study 05053-02 Pathology Tables

NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97
Route: GAVAGE                                                                                                     Time: 08:53:04




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|             
                                           | 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +  +  +  A  +  +  A  +  +  +  +  +  M  +  M  +  A  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   1      |             
      Inflammation, Acute                  |                                                                   3      |             
      Necrosis                             |                                                                   2      |             
      Lymphoid Nodule, Hyperplasia         |    1           1  2                 1                 1     1  1     1  1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                            2                                             |             
      Basophilic Focus                     |                                              X                           |             
      Fatty Change, Focal                  |    1                                                                     |             
      Hematopoietic Cell Proliferation     | 2  1     1  2  2     1  1  2        2     1  1  2  1     1  2  2  1  1  2|             
      Infarct                              |                                                       3                  |             
      Mineralization                       |                                                                          |             
      Necrosis                             | 1              2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +        +           +           +  +        +|             
      Inflammation, Acute                  | 2                          3        3           2           3  2        2|             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |                                                                      2   |             
      Forestomach, Angiectasis             |                                                                   1      |             
      Forestomach, Hyperkeratosis          |          1                                                           1  2|             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                      1  1|             
      Glandular, Hyperplasia               |          1                                                               |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |          1                                               1     1  1      |             
      Glandular, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X                           |             
      Hematopoietic Cell Proliferation     | 1                          1                                1  1        1|             
      Capsule, Hyperplasia                 | 1  2     2  1  1  2     1  1        1  1  1  1  1  1  3  1  1  1  1     1|             
      Medulla, Hyperplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|             
                                           | 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     +  M  +  +  M  +  M  M  +  +  M  M  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|             
      Pars Distalis, Angiectasis           |                   2                                                      |             
      Pars Distalis, Hyperplasia           |    1     1     1        2     1        1                 3     1        1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Cyst                |                                                          X               |             
      Follicular Cell, Hyperplasia, Focal  |    1                                   1           1                     |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                      M     M                                   M         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Abscess                              |             2                       3                       4           3|             
      Cyst                                 |    X        X     X     X              X                             X   |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |             1                                                            |             
      Bilateral, Abscess                   | 4              4     4     4                    4              4         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                2                                                         |             
      Inflammation, Acute                  | 1              1        1           1        1                 2        1|             
      Necrosis                             |                                                                          |             
      Endometrium, Hyperplasia             | 3        2     1        2              2  2              2        2  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                         2                                                |             
      Inguinal, Hyperplasia, Plasma Cell   |                         3                                                |             
      Lumbar, Hyperplasia, Lymphoid        | 4                                                                        |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Lumbar, Necrosis                     |                                                                          |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|             
                                           | 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation                    |                                                                         1|             
      Mandibular, Inflammation, Acute      | 3                                                                        |             
      Mediastinal, Angiectasis             |             2                                                            |             
      Mediastinal, Bacterium               |                                                             X            |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |             1  1                             1  1           1  1         |             
      Mediastinal, Hyperplasia, Plasma Cell|                1                                               2         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                            2                                            2|             
      Mediastinal, Inflammation, Acute     |                                                 3              3        2|             
      Mediastinal, Necrosis                | 2                    3                                                   |             
      Mesenteric, Angiectasis              |                1  1              1  1                                1   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |             2  2  1        1     3  2                    2  2        1   |             
      Mesenteric, Hemorrhage               |                               2                                          |             
      Mesenteric, Hyperplasia, Lymphoid    | 4                                                                        |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                             2            |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                            2                                             |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |             2  1        2                                                |             
      Renal, Hyperplasia, Lymphoid         | 4                                                                        |             
      Renal, Hyperplasia, Plasma Cell      |                3        3                                                |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |             2              3                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Hematopoietic Cell Proliferation     | 3  1     1  2  3  1     2  3        2  1  2  2  3     3  2  3  3  2  2  3|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Necrosis                             |                                                       1                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M     M  +  +  M  M  M  M  +  +  +  M  M  +  M  M  M  M  M  M  +  M  M|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  M     +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Metaplasia,     |                                                                          |             
           Osseous                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 0| 7| 7| 6| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 8| 3| 3| 9| 3| 6| 3| 0| 0| 3| 9| 3| 3| 4| 8| 3| 3| 3| 0| 1| 3| 3| 2|             
                                           | 1| 5| 9| 6| 5| 4| 6| 5| 5| 0| 2| 6| 8| 5| 6| 2| 2| 6| 5| 5| 5| 6| 6| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                      X                                                   |             
      Inflammation, Acute                  |                                              1              1            |             
      Inflammation, Chronic Active         | 1                                                                       1|             
      Alveolar Epithelium, Hyperplasia     |                            1                                             |             
      Pleura, Inflammation, Acute          |                      2     1                 2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                 1           2           1|             
      Metaplasia, Osseous                  |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Glomerulus, Inflammation, Acute      | 2              2                             1                 1        1|             
      Papilla, Mineralization              | 1        1                    1     1                 1                  |             
      Papilla, Necrosis                    |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9|            |
                                           | 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia         |       1              1        2  1           1              1     1      |     16  1.1|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |       2     2  1  2     1  3           1     2  1        1  1        2  1|     32  1.5|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                          1               |      1  1.0|
      Necrosis                             |                2              2                          1               |      5  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +     +     +  +        +        +           +           +   |  16        |
      Inflammation, Acute                  | 2           2     2     2  1                 3           2               |     14  2.2|
      Fat, Necrosis                        |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Necrosis, Coagulative                |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Forestomach, Acanthosis              |                                                    2                     |      2  2.0|
      Forestomach, Angiectasis             |                                                                          |      1  1.0|
      Forestomach, Hyperkeratosis          |       1                                         1  1                     |      6  1.2|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                            2                       2                     |      4  1.5|
      Glandular, Hyperplasia               |                                                                          |      1  1.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                   1      |      5  1.0|
      Glandular, Necrosis                  |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9|            |
                                           | 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1           1     1        3                                             |      9  1.2|
      Capsule, Hyperplasia                 | 1  1  1     1  2     1     1  2  1  1  2     2  1        1  2  1  1     2|     38  1.3|
      Medulla, Hyperplasia                 |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +  M  M  +  M  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
      Pars Distalis, Angiectasis           |    2                             2                          1            |      4  1.8|
      Pars Distalis, Hyperplasia           |             1  1  1                 2  2                    1     1      |     16  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Cyst                |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Focal  |                                                                      1   |      4  1.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                       M                                                |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Abscess                              | 4           4  2  3  1              4           3        4           2   |     13  3.0|
      Cyst                                 |    X     X                             X                          X     X|     11     |
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Bilateral, Abscess                   |       3                 4  4                 4                           |     10  3.9|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |       +                                                                  |   1        |
      Inflammation, Acute                  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                              3           3               |      2  3.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Acute                  | 1              1     1  1                 1                       2  2   |     14  1.2|
      Necrosis                             |                                        2                                 |      1  2.0|
      Endometrium, Hyperplasia             |          1     2     2           2  3  1  1           2     1  2  2      |     20  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9|            |
                                           | 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myelofibrosis                        |                      2                 2                 2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|  44        |
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  4.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      | 2                                                                        |      1  2.0|
      Lumbar, Necrosis                     | 2                                                                        |      1  2.0|
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Mandibular, Inflammation, Acute      |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  2.0|
      Mediastinal, Bacterium               |                                                                          |      1     |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |             1              1                                             |      8  1.0|
      Mediastinal, Hyperplasia, Plasma Cell|                            2                                             |      3  1.7|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |             3     2                                                      |      4  2.3|
      Mediastinal, Inflammation, Acute     |                                                                          |      3  2.7|
      Mediastinal, Necrosis                | 3                 1                                                      |      4  2.3|
      Mesenteric, Angiectasis              |                                              1                    1      |      7  1.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   2  1     2                 3        1  2        2      |     16  1.8|
      Mesenteric, Hemorrhage               |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Mesenteric, Hyperplasia, Plasma Cell |                                        1                                 |      2  1.5|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                                                1         |      1  1.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      3  1.7|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     | 3  1  3  2  2  3  3  2  3  4     1  1  2  1  3  2     1  3  2  2  3  3  1|     43  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9|            |
                                           | 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |    1                 1                                1                  |      4  1.5|
      Necrosis                             |                                                    2                     |      2  1.5|
      Pigmentation                         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  M  +  +  +  M|  37        |
      Atrophy                              |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  +  M  M  M  M  M  +  +  +  M  M  +  M  +  M  +  +  M  M  M  M|  17        |
      Galactocele                          |                               X  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|  40        |
      Hyperkeratosis                       |                                     2                                    |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                     1                                    |      1  1.0|
      Subcutaneous Tissue, Metaplasia,     |                                                                          |            |
           Osseous                         |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Joint, Hyperostosis                  |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thalamus, Mineralization             |             2                          2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bacterium                            | X                                                                        |      2     |
      Inflammation, Acute                  | 2                          1                                             |      4  1.3|
      Inflammation, Chronic Active         |             1                                            1               |      4  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Pleura, Inflammation, Acute          |                   1                                                      |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 6| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 1| 3| 8| 3| 2| 3| 8| 4| 9| 0| 3| 3| 3| 2| 3| 0| 3| 2| 3| 4| 3| 3| 9|            |
                                           | 4| 5| 8| 5| 5| 5| 6| 5| 7| 5| 2| 0| 5| 5| 6| 4| 5| 0| 6| 3| 5| 3| 6| 6| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                             1            |      1  1.0|
      Inflammation, Chronic Active         | 1           1     1        2                                             |      7  1.3|
      Metaplasia, Osseous                  |                                                                      1   |      1  1.0|
      Cortex, Mineralization               |       1                                                                  |      1  1.0|
      Glomerulus, Inflammation, Acute      |                                                                          |      5  1.4|
      Papilla, Mineralization              |                                                                          |      5  1.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|             
                                           | 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     A        A  +           +  +  A  M           +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +        +  +           +  +  +  A                    +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +        +  +     +     +  +  A  A  +                 +  +   |             
      Mineralization                       |                               1                                          |             
      Necrosis                             |                               3                                          |             
      Epithelium, Hyperplasia              |                               1                                          |             
      Lymphoid Nodule, Hyperplasia         |                                     2  1        2                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                1        1                                1     2  2      |             
      Hematopoietic Cell Proliferation     | 1  1  1           1  1     2  1  1  1  1     1  1  1  1  1  1     1  1   |             
      Inflammation, Chronic Active         |          1                                                               |             
      Necrosis                             |                      1        1                                          |             
      Pigmentation                         |                1                                1                       1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +     +  +     +  +              +     +                    +  +   |             
      Inflammation, Acute                  |    2  1     2  2     3  2              2     1                    2  2   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +     +  M           +  +  +  +                    +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +        +  +           +  +  +  +                    +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |                                                    1     2     2         |             
      Forestomach, Hyperkeratosis          | 1           1                                      2     1  1  2         |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                1        1|             
      Glandular, Hyperplasia               | 1                                                     1                  |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           | 1                                                  1                     |             
      Glandular, Necrosis                  |                1                                                         |             
      Glandular, Pigmentation              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +        +  +           +  +  +  +                    +  +   |             
      Cardiomyopathy                       |                                                                          |             
      Mineralization                       |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    M  +     +        +  +           +  +  +  +  +                 +  +   |             
      Hematopoietic Cell Proliferation     |                                     1  1                             1   |             
      Capsule, Hyperplasia                 |       1     1           1           1  1        1                 2  1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +     +  M           +  +  +  +                    +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +     +  +  +  +     +  M  +  +  M     +     +        +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  +     +        +  +           +  +  M  +        +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|             
                                           | 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                     2  1              1     1            |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Focal  |                   1                                                      |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +        +  +  +  +  +        +  +     +  +   |             
      Abscess                              | 3  4  4        2     4     4                 4              4     3      |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                          3               |             
      Mineralization                       |                2                                                         |             
      Pigmentation                         |                                                                          |             
      Bilateral, Abscess                   |             4     4     3           4  4        4                    4   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +  +  +        +  +  +  +  +  +  +     +     +  +  +   |             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Inflammation, Acute                  |    1        2     2                 1                             2      |             
      Endometrium, Hyperplasia             | 2                 2  1           2  1     2     1  2     2     1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +        +  +           +  +  +  +                    +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +  +     +     +  +  +  +  +                 +  +  +|             
      Axillary, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                              1                           |             
      Lumbar, Hyperplasia, Plasma Cell     |                                     2                                    |             
      Lumbar, Necrosis                     |                               2                                          |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                     2  2                             2   |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                2                    2                                1   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Necrosis                |             2                                                     2      |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                     3        2  2                 2  2   |             
      Mesenteric, Hemorrhage               |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|             
                                           | 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                        2                                 |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                     1                                1   |             
      Renal, Hyperplasia, Plasma Cell      |                                     2                                2   |             
      Renal, Necrosis                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  M  +  +  +        +  +  +  +  +        +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  2  1  3  2     2  3  2        3  3     3  2              1  3  3  2|             
      Hemorrhage                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  M     M        +  +           +  +  M  M                    +  +   |             
      Atrophy                              |                         1                                                |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M     M        M  +           +  +  M  M                    M  +   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +        +  +           +  +  +  +                    +  +   |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +        +  +           +  +  +  +                    +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +        +  +           +  +  +  +                    +  +   |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +        +  +     +     +  +  +  +                    +  +   |             
      Bacterium                            |       X     X        X                                                   |             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                              2                           |             
      Pleura, Inflammation, Acute          |       2     3        2  2                                         1  2   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  M     +        +  M           +  +  M  M                    +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                 +                     |             
      Hyperplasia                          |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +     +  +           +  +  +  +                    +  +  +|             
      Inflammation, Acute                  |                                        3                             2   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 7| 5| 6| 7| 5| 5| 7| 6| 7| 6| 5| 6| 4| 6| 7| 7| 7| 7| 7| 5| 5| 7|             
                             DAY ON TEST   | 5| 2| 9| 4| 6| 5| 4| 6| 7| 4| 7| 4| 2| 9| 3| 9| 5| 4| 4| 4| 3| 4| 8| 9| 0|             
                                           | 0| 3| 4| 1| 5| 6| 1| 8| 6| 1| 3| 1| 8| 0| 3| 5| 9| 1| 1| 1| 6| 1| 4| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Glomerulus, Inflammation, Acute      |    1                                2        1                           |             
      Papilla, Necrosis                    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    M  M     +        +  +           +  +  +  +                    +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4|            |
                             DAY ON TEST   | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9|            |
                                           | 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +  M  +  +  +  +  +  +  M  +     +  M     +  +  +  M  +  +  M|  36        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +              M  M  +  +  +  +     A        +  A     M  +     A        +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +  +  +  +  +  +     +        +  +     +  +     +        +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A           +  +  +  +  +  A  +     +        +  M     +  +     A        +|  22        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
      Lymphoid Nodule, Hyperplasia         |             1                                1                           |      5  1.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                X         |      1     |
      Fatty Change, Diffuse                |             2                 1                                          |      2  1.5|
      Fatty Change, Focal                  |    1                                                           1         |      7  1.3|
      Hematopoietic Cell Proliferation     | 1              1  1  2  1  1  1  1  1  1     2  1     1  2  1     1      |     34  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis                             |       1              1                                                   |      4  1.0|
      Pigmentation                         |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +  +  +     +        +        +        +  +               |  19        |
      Inflammation, Acute                  | 2              2  1  3     2        2        4        2  2               |     19  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A           +  +  +  +  +  +  +     M        +  +     +  +  +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +  M  +  +  +  +     +        +  +     M  +     +     +  +|  24        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Forestomach, Acanthosis              |                                                                          |      3  1.7|
      Forestomach, Hyperkeratosis          | 1  1        2     1              1        1        1                     |     13  1.2|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      2  1.0|
      Glandular, Hyperplasia               |    1                                   1                                 |      4  1.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |    1                                               1                    1|      5  1.0|
      Glandular, Necrosis                  |                                              1                          2|      3  1.3|
      Glandular, Pigmentation              |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +  +  +  +  +  +  +     +        +  +     +  +     +        +|  26        |
      Cardiomyopathy                       |                   1                                      1               |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +              +  +  +  +  +  +     +        +  +     +  +  +  +  +     M|  26        |
      Hematopoietic Cell Proliferation     |                1           1                             1  1     1      |      8  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4|            |
                             DAY ON TEST   | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9|            |
                                           | 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 | 1              1     1              1        1  1     1  2  1            |     17  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A           +  +  +  +  +  +  +     M        +  +     +  +  +  +  M     +|  25        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M     +  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +     +  M  +  +  +  +     M  +     +  M     +  +     +  +  +  +|  27        |
      Pars Distalis, Angiectasis           |          2                             2                          1  2   |      5  1.6|
      Pars Distalis, Hyperplasia           |                1                             3           1               |      7  1.4|
      Pars Distalis, Pigmentation          |                                                                      1   |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia, Focal  |    1                             1                                       |      3  1.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +              +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|  36        |
      Abscess                              |                   3                 4        4           4  3  4  4      |     16  3.6|
      Cyst                                 |                   X        X     X                          X        X   |      5     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Mineralization                       |                                                                      1   |      2  1.5|
      Pigmentation                         |                                                                      2   |      1  2.0|
      Bilateral, Abscess                   | 4              4     4  3  4  4                 4     4                  |     15  3.9|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +        +|  39        |
      Abscess                              |                                                 3                        |      1  3.0|
      Angiectasis                          |                                        1                                 |      1  1.0|
      Inflammation, Acute                  | 1  2           1        1  2  1     1                                    |     12  1.4|
      Endometrium, Hyperplasia             |    2     2     1              1  2     1              1     2           1|     19  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +  +  +  +  +  +     +        +  +     +  +     +        +|  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +        +  +  +  +  +  +  +     +        +  +     M  +  +  +  +  +  M|  32        |
      Axillary, Hyperplasia, Plasma Cell   |                                                                1         |      1  1.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                1                                                         |      2  1.0|
      Lumbar, Hyperplasia, Plasma Cell     |                2                             2           1               |      4  1.8|
      Lumbar, Necrosis                     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4|            |
                             DAY ON TEST   | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9|            |
                                           | 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                2        2                    1                 1         |      7  1.7|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                         2                                                |      4  1.8|
      Mediastinal, Hyperplasia, Plasma Cell|                2           2                 2           3               |      4  2.3|
      Mediastinal, Necrosis                |                                                 2                        |      3  2.0|
      Mesenteric, Angiectasis              |    2                                                     2           1   |      3  1.7|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |    2                                         2           2           2   |      9  2.1|
      Mesenteric, Hemorrhage               |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Plasma Cell |                            2                             2               |      2  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                   2      |      2  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                              1           1               |      4  1.0|
      Renal, Hyperplasia, Plasma Cell      |                3                             2           3  2            |      6  2.3|
      Renal, Necrosis                      | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +              +  +  +  +  +  +     +        +  +  +  +  +  +  +  +     +|  35        |
      Hematopoietic Cell Proliferation     | 2              3  2  2  2  3  3     3        3  3  2  3  3  4  3  3      |     32  2.6|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +  M  M  M  +  M  +     M        +  +     +  +     M        M|  14        |
      Atrophy                              |                                                                          |      1  1.0|
      Cyst                                 |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              M  M  M  +  M  M     M        +  M     M  +     +        +|  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +  +  +  +  +  +     +        +  +     +  +     +        +|  25        |
      Subcutaneous Tissue, Necrosis        |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +  +  +  +  +  +     +        +  +     +  +     +        +|  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +  +  +  +  +  +     +        +  +     +  +     +        +|  25        |
      Inflammation, Acute                  |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +  +  +  +  +  +  +     +        +  +     +  +     +        +|  27        |
      Bacterium                            |                      X                                                   |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 6| 6| 5| 5| 6| 5| 5| 7| 5| 7| 7| 5| 4| 7| 5| 5| 6| 5| 7| 6| 4|            |
                             DAY ON TEST   | 2| 4| 7| 4| 6| 1| 5| 6| 0| 6| 4| 4| 3| 4| 4| 5| 9| 4| 4| 9| 7| 4| 1| 8| 9|            |
                                           | 1| 1| 7| 1| 7| 4| 3| 6| 1| 1| 5| 1| 8| 1| 1| 8| 0| 1| 1| 1| 4| 2| 5| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                1         |      1  1.0|
      Inflammation, Chronic Active         |                                     1                 1        1         |      4  1.3|
      Pleura, Inflammation, Acute          | 2                    3     1                 1  2                        |     11  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | M              +  +  +  +  +  M     +        +  M     +  M     +        M|  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +     +|  32        |
      Inflammation, Acute                  |                                                                   3      |      3  2.7|
      Inflammation, Chronic                |                                           1                              |      1  1.0|
      Inflammation, Chronic Active         |                               1     1        2                           |      4  1.3|
      Necrosis                             |                      2                                                   |      1  2.0|
      Cortex, Mineralization               |                      1                                                   |      1  1.0|
      Glomerulus, Inflammation, Acute      |                1                                         2  2            |      6  1.5|
      Papilla, Necrosis                    |                                                                   3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A              +  A  +  +  +  +     M        +  M     M  +     M        +|  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|             
                                           | 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                 1                    1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         | 1     1                                   1        2  1        2         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                       X                  |             
      Fatty Change, Diffuse                |          1                                         2                     |             
      Fatty Change, Focal                  |             2        1              1  1     2  1     1     2  2     2  1|             
      Hematopoietic Cell Proliferation     | 2  1  2  2  1     1  1  1  2  2  2     1  1     1  1  1  1     1     1   |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |             1           1                 1              1               |             
      Pigmentation                         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +     +  +        +     +  +  +     +                                 |             
      Inflammation, Acute                  | 2  2     1  2        2     1  4  3     1                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |                                              1                       2   |             
      Forestomach, Hyperkeratosis          |                                              1     1                 2   |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                      2   |             
      Glandular, Ectopic Tissue            |                                                                          |             
      Glandular, Hyperplasia               |                                           1                    1         |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                           1                              |             
      Glandular, Mineralization            |                                                                          |             
      Glandular, Necrosis                  |                                                             2            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                           1                              |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1  1           1                                                   |             
      Capsule, Hyperplasia                 | 1  1  1  1  1  2     2     1  1        1     1  1  1  2  2  1  2     1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|             
                                           | 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Medulla, Hyperplasia                 |                                                          1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  M  +  M  M  M  +  +  +  +  +  +  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    1                    1|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  1  3                                   1     2     2               |             
      Pars Intermedia, Hyperplasia         |                                                                         1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Focal  |       1     1           1           1           1        1     1     1   |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                    M  M        +     M  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4     4  4  4     4  4     4  4        3                                 |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                   X  X   |             
      Pigmentation                         |                                                                          |             
      Bilateral, Abscess                   |    4                             4                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       2                          2                                       |             
      Hemorrhage                           |                                           2                              |             
      Inflammation, Acute                  |             1                 1        2                       2         |             
      Endometrium, Hyperplasia             |       1        2        1           1     1     2  2  2        2     1  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lumbar, Angiectasis                  |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |    1                             3                                       |             
      Mandibular, Angiectasis              |                   3                                                      |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |       1  1                       1                                       |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    | 1     2  2                 1                                             |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell| 3  3     2           3        2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|             
                                           | 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Necrosis                |                   2        2                                             |             
      Mesenteric, Angiectasis              |                                                 2     1                 1|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    | 3     1                          1              1     1                  |             
      Mesenteric, Hyperplasia, Plasma Cell | 2                                                                        |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |       2  1                                                               |             
      Renal, Hyperplasia, Plasma Cell      |    3                 1                                                   |             
      Renal, Necrosis                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  3  3  3  2  1  2  3  2  3  3  3     2  1  1  1  2  2  1  1  3  1  2  2|             
      Hyperplasia, Lymphoid                |                                     1                                    |             
      Capsule, Fibrosis                    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                            2  1                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  +  M  +  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +|             
      Necrosis                             |                                                                         2|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                   X                                                      |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                1                    1        1                           |             
      Inflammation, Chronic Active         |                   2        1                                             |             
      Alveolar Epithelium, Hyperplasia     |    1                 1                                   1               |             
      Pleura, Inflammation, Acute          |             1                          1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 5| 6| 7| 5| 5| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 7| 4| 6| 0| 3| 3| 4| 3| 3| 0| 8| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3|             
                                           | 4| 0| 9| 6| 9| 5| 7| 5| 5| 9| 4| 0| 5| 4| 5| 5| 5| 5| 6| 6| 7| 6| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 1  1     1                    1  1                                       |             
      Pigmentation                         |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Glomerulus, Inflammation, Acute      |       1              2                                                   |             
      Papilla, Mineralization              |          1                                                               |             
      Papilla, Necrosis                    |                                                       1                  |             
      Renal Tubule, Casts                  |                                           1                              |             
      Renal Tubule, Regeneration           |                                           1              1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7|            |
                             DAY ON TEST   | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3|            |
                                           | 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +  +  +  +  A  +  M  M  +  A  A  +  +  +  +  +  +  +  +  +  A  M  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoid Nodule, Hyperplasia         |             1  2     1           1     1  1  1     1                    1|     15  1.2|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Fatty Change, Diffuse                |                      2                                      2            |      4  1.8|
      Fatty Change, Focal                  |             1  1                          1  1  2  1           2     1  1|     20  1.4|
      Hematopoietic Cell Proliferation     | 1        2  1  1  1     3  3     2     2  2     1  1     1     1  1  2  1|     36  1.4|
      Infarct                              |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         |       1                                                                  |      1  1.0|
      Necrosis                             | 1                 1                                1              1      |      8  1.0|
      Pigmentation                         |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +     +  +     +        +  +              +     +           +   |  19        |
      Inflammation, Acute                  | 2        3     2  3     2        3  1              2     3           3   |     19  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Acinus, Hyperplasia, Focal           |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Acanthosis              |                                                                          |      2  1.5|
      Forestomach, Hyperkeratosis          |                                     1     1           1                  |      6  1.2|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Glandular, Ectopic Tissue            |                                     X                                    |      1     |
      Glandular, Hyperplasia               |                                           1                    1         |      4  1.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |             1                                1                           |      3  1.0|
      Glandular, Mineralization            |                                     1                                    |      1  1.0|
      Glandular, Necrosis                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   1        |
      Inflammation, Chronic Active         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                       1                  |      2  1.0|
      Mineralization                       |                                                       1                  |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7|            |
                             DAY ON TEST   | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3|            |
                                           | 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     | 1                 1     1                                         1  1   |      8  1.0|
      Capsule, Hyperplasia                 | 1     1  1  2     1  2  1  1  1  1     2  2  2        1     2  1  1  1  3|     38  1.3|
      Medulla, Hyperplasia                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  M  +  +  M  +  M  +  M  +  +  +  +  +  M  +  M  M  M  M  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Pars Distalis, Angiectasis           |                                                                          |      2  1.0|
      Pars Distalis, Cyst                  |                      X                                                   |      1     |
      Pars Distalis, Hyperplasia           |       1     2           1  1                 1  1           2            |     13  1.5|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Follicular Cell, Hyperplasia, Focal  | 1           1        1     1           1     1  2     1     1            |     17  1.1|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                           1                              |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                         M                                M  M  M  M     M|   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Abscess                              | 4              4  4  2  4        4  4     4              4        4      |     19  3.8|
      Angiectasis                          |                      2                                                   |      1  2.0|
      Cyst                                 |             X                                               X            |      4     |
      Pigmentation                         |                                                             2            |      1  2.0|
      Bilateral, Abscess                   |          4                 4           4           3                 4   |      7  3.9|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |          2           1  2  1     1  1  2                             1   |     12  1.4|
      Endometrium, Hyperplasia             |       2     1        1  2              1  2  2  2           2  2        2|     22  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +|  45        |
      Lumbar, Angiectasis                  |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7|            |
                             DAY ON TEST   | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3|            |
                                           | 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                   2                                                      |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                            1                                             |      3  1.7|
      Mandibular, Angiectasis              |                                                                          |      1  3.0|
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                         3                 2                              |      5  1.6|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                            1           2  1                              |      7  1.4|
      Mediastinal, Hemorrhage              |    2                                                                     |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell| 2                       2  2     2                                   2   |     10  2.3|
      Mediastinal, Necrosis                |                   2              1                                   1   |      5  1.6|
      Mesenteric, Angiectasis              |                                  2           1                           |      5  1.4|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                         3  3     2     2  2  2                           |     11  1.9|
      Mesenteric, Hyperplasia, Plasma Cell |          1                                                               |      2  1.5|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                            2                                             |      3  1.7|
      Renal, Hyperplasia, Plasma Cell      |                   2                                                      |      3  2.0|
      Renal, Necrosis                      |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  1  2  3     3  3  2  3  4  1  3  2  3  1  1  1  3  1  2  1  1  3  3  1|     48  2.1|
      Hyperplasia, Lymphoid                |                                           1           2     2  3         |      5  1.8|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  +  +  +  M  M  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +|  35        |
      Atrophy                              |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  +  M  M  M  M  M  +  +  +  M  M  M  +  M  M  M  +|  13        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Necrosis                             |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 3| 6| 6| 7| 5| 4| 7| 7| 5| 3| 6| 6| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 5| 7|            |
                             DAY ON TEST   | 7| 7| 7| 2| 3| 3| 4| 3| 1| 6| 0| 1| 7| 3| 3| 3| 3| 6| 7| 5| 3| 3| 6| 8| 3|            |
                                           | 5| 2| 2| 2| 6| 7| 0| 6| 9| 5| 3| 6| 1| 5| 5| 6| 5| 0| 1| 8| 5| 6| 7| 3| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |       2                                                                  |      1  2.0|
      Bacterium                            |          X     X                 X                                X      |      5     |
      Edema                                |                   1                                                      |      1  1.0|
      Hemorrhage                           | 1              1              1                                          |      6  1.0|
      Inflammation, Chronic Active         |                   1        1                                             |      4  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.0|
      Pleura, Inflammation, Acute          |          1     2                 1  1  3           1              2      |      9  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                                 |      1     |
      Glomerulosclerosis                   |                                                       2                  |      1  2.0|
      Inflammation, Acute                  |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         |                         1        1  1  1                 1        1      |     11  1.0|
      Pigmentation                         |                                                       1                  |      1  1.0|
      Cortex, Mineralization               |                                                          1        1      |      2  1.0|
      Glomerulus, Inflammation, Acute      |                                           2        1                 1   |      5  1.4|
      Papilla, Mineralization              |                   1                          1                           |      3  1.0|
      Papilla, Necrosis                    |                                                                          |      1  1.0|
      Renal Tubule, Casts                  |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|             
                                           | 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  4                                       |             
      Ileum, Epithelium, Hyperplasia       |                                                                          |             
      Lymphoid Nodule, Hyperplasia         |    2           1        1  2           2        2  1     2  2  2     2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X                                 |             
      Fatty Change, Focal                  |             2        1           1                                       |             
      Hematopoietic Cell Proliferation     |                               1  1     1     1     1  1  1  1     1     1|             
      Infarct                              | 1                                                                        |             
      Mineralization                       |                      1                                               1   |             
      Necrosis                             | 1           1        2     1                                         2   |             
      Pigmentation                         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Fat, Necrosis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                   1      |             
      Acinus, Hyperplasia                  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Forestomach, Acanthosis              |             2  1                                                         |             
      Forestomach, Fibrosis                |                1                                                         |             
      Forestomach, Hyperkeratosis          |             1  2                                                         |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                1                                                         |             
      Forestomach, Ulcer                   |             1  1                                                         |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                   1      |             
      Glandular, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                       1     1            |             
      Mineralization                       |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    1  1     1     2     1  2     1  1  2     1  1     1     2  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|             
                                           | 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Hyperplasia                  |                                                       1                  |             
      Cortex, Hypertrophy, Focal           |                                                 1                        |             
      Medulla, Hyperplasia                 |       1                                      1           2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  M  M  +  M  M  +  M  +  M  +  M  +  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                   X                                                      |             
      Pars Distalis, Hyperplasia           |                                              1        1                  |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                   X      |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +        +                                      +  +                  |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |    1        1                                      1                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |    1                                         1                          1|             
      Seminiferous Tubule, Mineralization  |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                             2            |             
      Mesenteric, Angiectasis              |       1  1                             1     1  1        2  1  2  3     2|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |       1                          1     1     1           1  3     1     1|             
      Mesenteric, Necrosis                 |                                                                          |             
      Renal, Necrosis                      |                                                                          |             
      Thoracic, Angiectasis                |                               2                                          |             
      Thoracic, Necrosis                   |                               1                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|             
                                           | 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              | 2                                                                        |             
      Hematopoietic Cell Proliferation     |       1     2  1  1  1     1  2  1  1  1     1  1  1  2  1  2  2  1  1  3|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  M  M  +  M  +  +  M  +  M  +  +  +  +  +  M  +  +  M|             
      Atrophy                              |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Necrosis                             |                                                                         3|             
      Subcutaneous Tissue, Metaplasia,     |                                                                          |             
           Osseous                         |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | 1     2  2  2     2  1     2  2  1  2  2     1        1  1  2  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Tumor                        |                                                                          |             
      Hemorrhage                           |       2                             1        1                           |             
      Infiltration Cellular, Histiocyte    |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X           X                                X              X|             
      Embolus Tumor                        |                                                                          |             
      Inflammation, Chronic Active         |             2                                               2            |             
      Cortex, Mineralization               | 2  1              1           1           1           1                  |             
      Papilla, Mineralization              |                                                 1                        |             
      Renal Tubule, Casts                  |             1  2                                                         |             
      Renal Tubule, Degeneration           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 4| 3| 4| 8| 4| 4| 4| 4| 4| 4| 3| 4| 8| 4| 4| 3| 3| 4| 3| 4| 4| 1| 2|             
                                           | 5| 6| 0| 4| 0| 8| 0| 2| 1| 1| 0| 0| 4| 0| 8| 1| 1| 4| 6| 1| 4| 1| 1| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Regeneration           |             1  1                                      1                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic Active         |                                                             2            |             
      Transitional Epithelium, Hyperplasia |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4|            |
                                           | 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Nodule, Hyperplasia         |                                                 1           1            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Ileum, Epithelium, Hyperplasia       |                         1                                                |      1  1.0|
      Lymphoid Nodule, Hyperplasia         |    1  2  1  1     1  1           1     3  2     1     2     2  1     1  1|     26  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                              X                           |      2     |
      Fatty Change, Focal                  |             1  1     1           1                                       |      7  1.1|
      Hematopoietic Cell Proliferation     | 1           1              1  1        1              1     1  1     1  1|     20  1.0|
      Infarct                              |                                                                          |      1  1.0|
      Mineralization                       |                         1                                                |      3  1.0|
      Necrosis                             |             1     1     2  1                                            1|     10  1.3|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   2        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                               1                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Glandular               |                            1                                             |      1  1.0|
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
      Forestomach, Acanthosis              |                                     1                                   1|      4  1.3|
      Forestomach, Fibrosis                |                                                                          |      1  1.0|
      Forestomach, Hyperkeratosis          |                         2           2                                   1|      5  1.6|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Forestomach, Ulcer                   |                                                                          |      2  1.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                              1           1  1            |      4  1.0|
      Glandular, Mineralization            |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4|            |
                                           | 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  1  1  1     1     2  1     1        3  1  1     2  2     2  1     1   |     31  1.4|
      Cortex, Hyperplasia                  |                                                                          |      1  1.0|
      Cortex, Hypertrophy, Focal           |                                                                          |      1  1.0|
      Medulla, Hyperplasia                 | 2     1                 1                                      1        1|      8  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  +  +  M  +  M  M  M  M  +|  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Cyst                  |       X                                                                  |      2     |
      Pars Distalis, Hyperplasia           | 1                                                                        |      3  1.0|
      Pars Intermedia, Cyst                |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Focal  |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                    +           +|   7        |
      Dilatation                           |                                                             1            |      1  1.0|
      Inflammation, Chronic Active         |                                        3                                1|      5  1.4|
      Necrosis                             |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  46        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         | 1                       1  1                                1            |      7  1.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4|            |
                                           | 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  2.0|
      Mesenteric, Angiectasis              | 1  1  1  2  3     2  1  2     1     3        1     1                     |     22  1.5|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |       2  2  1           1                    1     1  1                  |     15  1.3|
      Mesenteric, Necrosis                 |                                     2                                    |      1  2.0|
      Renal, Necrosis                      |                                     1                                    |      1  1.0|
      Thoracic, Angiectasis                |                                                                          |      1  2.0|
      Thoracic, Necrosis                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                           1                              |      2  1.0|
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  1  1  2  1  1  2     3  1  3  1  1  1  2              1  2  1  1  1  1|     40  1.4|
      Hyperplasia, Lymphoid                | 2                    2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +|  35        |
      Atrophy                              |                               1     2                                    |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Bacterium                            |                               X                                          |      1     |
      Necrosis                             | 3        2              3                                                |      4  2.8|
      Subcutaneous Tissue, Metaplasia,     |                                                                          |            |
           Osseous                         |          2                                                               |      1  2.0|
      Subcutaneous Tissue, Necrosis        |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Tarsal, Hyperostosis          | 2  2  1  1     1  1  2  2  2  2        2  2  2              2        2  2|     35  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Mineralization             |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Tumor                        |                         X                                                |      1     |
      Hemorrhage                           |    1     1     1                          1                              |      7  1.1|
      Infiltration Cellular, Histiocyte    |                         2                                                |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |          1                                            1                  |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 3| 4| 9| 4| 4| 3| 4| 3| 4| 4| 4| 3| 3| 4| 4| 3| 3| 2| 3| 4| 4|            |
                                           | 4| 1| 1| 2| 6| 2| 4| 2| 2| 6| 2| 4| 4| 2| 2| 4| 4| 2| 2| 4| 6| 9| 4| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +     +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      4     |
      Embolus Tumor                        |                         X                                                |      1     |
      Inflammation, Chronic Active         |                   2                                                      |      3  2.0|
      Cortex, Mineralization               |    1        1        1     1     1  1  1        1  1  1  1        1  1   |     19  1.1|
      Papilla, Mineralization              |                                                                          |      1  1.0|
      Renal Tubule, Casts                  |                   2        1                                            1|      5  1.4|
      Renal Tubule, Degeneration           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |       1  1  1  1     1     1     1              1  1        1  1  1  1  2|     18  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Calculus Micro Observation Only      |          X                 X                                             |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .05 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +     M                 +                    +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +     +                 +                    A            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +                 +                    +            |             
      Circumanal Gland, Inflammation, Acute|                   1                                                      |             
      Lymphoid Nodule, Hyperplasia         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +     +                 +                    A            |             
      Duodenum, Fibrosis                   |                2                                                         |             
      Duodenum, Hyperplasia                |                2                                                         |             
      Duodenum, Inflammation, Chronic      |                                                                          |             
          Active                           |                2                                                         |             
      Duodenum, Necrosis                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                                                                        |             
      Cyst                                 |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |    2                                      2                       1  1   |             
      Hematopoietic Cell Proliferation     | 1                             1                                          |             
      Hemorrhage                           |                                        2                                 |             
      Mineralization                       |                                           1                              |             
      Necrosis                             |                2     2              1  2                                 |             
      Regeneration                         |                                        3                                 |             
      Thrombosis                           |                                        1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +     +                 +  +                 +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +     +                 +                    +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |       1                                                                  |             
      Forestomach, Acanthosis              |                                                                2         |             
      Forestomach, Fibrosis                |                                                                1         |             
      Forestomach, Hyperkeratosis          | 1                                                              2         |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                2         |             
      Forestomach, Mineralization          |                                                                          |             
      Forestomach, Ulcer                   |                                                                1         |             
      Glandular, Hyperplasia               |    1                                                  1                  |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                        1              1              1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +     +                 +                    +            |             
      Pericardium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .05 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +     +     +                 +     +                          +|             
      Capsule, Hyperplasia                 |          2     1                       1     1                          1|             
      Cortex, Hypertrophy                  |          1                                                               |             
      Medulla, Hyperplasia                 |                      1                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +     +                 +  +                 +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +     +                 +                    M            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +     +                 +                    +            |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +     +                 +                    +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +  +  +                 +                    +            |             
      Abscess                              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +        +                                                     +      |             
      Cyst                                 |             X                                                            |             
      Inflammation, Chronic Active         |    1                                                                     |             
      Necrosis                             |             2                                                            |             
                                            __________________________________________________________________________|             
   Prostate                                |                +     +                 +                    +            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +     +                 +  +                 +     +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                +  +  +                 +                    +            |             
      Spermatocele                         |                   X                                                      |             
      Seminiferous Tubule, Atrophy         |                1                                                         |             
      Seminiferous Tubule, Mineralization  |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +     +                 +                    +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +     M  +              +                    +           +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mesenteric, Angiectasis              |                2        1              1                    2           1|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |          1     1        2              1                                1|             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                1                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  +  +     +  +        +                    +     +      |             
      Angiectasis                          |                            1                                             |             
      Hematopoietic Cell Proliferation     |          1  2  2  1  1     1  3                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .05 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Mast Cell               |                            1                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  |                M     +                 +                    +            |             
      Atrophy                              |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                M     M                 M                    M            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +     +  +     +  +     +                    +        +   |             
      Bacterium                            |    X                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                  2                                       |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |    2                    2                                                |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Sebaceous Gland, Hyperplasia         |                                  2                                       |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | 2  2  2  2  1  2  1        2  1  2  2  1  2  1  1        2        2  2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +     +                 +                    +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 1                        |             
      Infiltration Cellular, Histiocyte    |                1                                            3            |             
      Inflammation, Chronic Active         |                   1                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +     +                 +                    +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +  +  +  +  +           +     +           +  +  +         |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |             1  2                             1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 6| 9| 0| 0| 3| 0| 0| 2| 0| 0| 0| 0| 0| 0| 7| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .05 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Renal Tubule, Casts                  |                                                                          |             
      Renal Tubule, Regeneration           |                2                             1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  A  +                 +                    +            |             
      Angiectasis                          |                2                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3|            |
                                           | 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .05 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +              +     +           +           +           +     +   |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                 +                 +                                 |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                                   +                                 |   7        |
      Circumanal Gland, Inflammation, Acute|                                                                          |      1  1.0|
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                    +              +                                 |   6        |
      Duodenum, Fibrosis                   |                                                                          |      1  2.0|
      Duodenum, Hyperplasia                |                                                                          |      1  2.0|
      Duodenum, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Duodenum, Necrosis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X                                                                        |      2     |
      Cyst                                 |                      1                                                   |      1  1.0|
      Fatty Change, Diffuse                |                                              2                           |      1  2.0|
      Fatty Change, Focal                  | 2                                                                        |      5  1.6|
      Hematopoietic Cell Proliferation     |             1                       1  1                                 |      5  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |       1                                                  1               |      3  1.0|
      Necrosis                             |       3                 2                                2  1            |      8  1.9|
      Regeneration                         |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Abscess                              |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                    +              +                          +      |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                       +           +     +                           |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Glandular               |                                                                          |      1  1.0|
      Forestomach, Acanthosis              |                                  2                       2               |      3  2.0|
      Forestomach, Fibrosis                |                                                                          |      1  1.0|
      Forestomach, Hyperkeratosis          |                   1              2                       2               |      5  1.6|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                          2               |      2  2.0|
      Forestomach, Mineralization          |                                                       1                  |      1  1.0|
      Forestomach, Ulcer                   |                                                          2               |      2  1.5|
      Glandular, Hyperplasia               |                1  1                                                      |      4  1.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           | 1              1                    1                                    |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3|            |
                                           | 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .05 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                                   +                                 |   6        |
      Pericardium, Inflammation, Acute     |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                                   +                       +         |   9        |
      Capsule, Hyperplasia                 |                                        1                                 |      6  1.2|
      Cortex, Hypertrophy                  |                                                                          |      1  1.0|
      Medulla, Hyperplasia                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                    +              +                          +      |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                                   M                                 |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +                                   +     M                           |   6        |
      Pars Distalis, Cyst                  |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                                   +                                 |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                         +                                            +   |   7        |
      Abscess                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +           +     +        +     +           +               |   9        |
      Cyst                                 |             X                                X                           |      3     |
      Inflammation, Chronic Active         |                         1                                                |      2  1.0|
      Necrosis                             |                               2                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +                                   +                                 |   6        |
      Hemorrhage                           |                                        1                                 |      1  1.0|
      Inflammation, Chronic Active         |                                        3                                 |      1  3.0|
      Necrosis                             |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                   +                 +     +         |  10        |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +                    +              +                             +   |   9        |
      Spermatocele                         |                                                                          |      1     |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  1.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                                   +                                 |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3|            |
                                           | 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .05 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  M     +     +        +           +        +              +  +     +|  15        |
      Lumbar, Hyperplasia, Plasma Cell     |                                        3                                 |      1  3.0|
      Mesenteric, Angiectasis              |                   1                             2              2  2     3|     10  1.7|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   1                             2              2  2     1|     10  1.4|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +              +              +     +  +                 +      |  18        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |    1  2  2              3              2        2                 2      |     15  1.7|
      Hyperplasia, Mast Cell               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M                    +              +                          +      |   6        |
      Atrophy                              |                         3                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M                                   M                                 |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +     +  +  +     +     +  +  +     +                 +  +  +|  23        |
      Bacterium                            |                         X                                         X      |      3     |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation, Acute                  |                         3                                                |      1  3.0|
      Inflammation, Chronic Active         |    2                                                                    1|      2  1.5|
      Necrosis                             |             3           3           2     2     2                 2      |      8  2.3|
      Prepuce, Inflammation, Chronic Active|                                        1                                 |      1  1.0|
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                   2                 1     1                              |      3  1.3|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                               1                                          |      1  1.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
      Joint, Tarsal, Hyperostosis          |    1  2  1  1  1  1  2  2  2  2  1  2  2  2  1  2  1  2        2  2  2  2|     40  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                                   +                                 |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 6| 7| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 9| 3| 3| 4| 4| 4| 4| 6| 7| 8| 3| 3|            |
                                           | 3| 3| 8| 3| 3| 3| 3| 3| 2| 3| 8| 8| 8| 3| 8| 8| 0| 0| 0| 0| 9| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .05 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |    1                                               1  1                  |      4  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                2         |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                       1                  |      2  1.0|
      Bronchiole, Inflammation, Acute      |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +        +              +                 +     +         |  20        |
      Cyst                                 |                                                                X         |      1     |
      Inflammation, Chronic Active         |                                                                2         |      4  1.5|
      Cortex, Mineralization               | 1              1                                                         |      2  1.0|
      Renal Tubule, Casts                  |                                                          1               |      1  1.0|
      Renal Tubule, Regeneration           | 1                                                        1               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                                   +                       +         |   7        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                        1                                 |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |          1              1                 1                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |    1  1     1        1        2        1  1  1     1  1  1  1  1     1   |             
      Lymphoid Nodule, Necrosis            |                               1                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change, Focal                  | 1     1     2                          1  1                    1         |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       1  1                    1     1                       1  1         |             
      Hemorrhage                           |                                     1                                    |             
      Mineralization                       |                            1                                             |             
      Necrosis                             |                            2        1                          1         |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              | 2           2                 2           2                       2      |             
      Forestomach, Cyst Epithelial         |                                                                          |             
          Inclusion, Multiple              |                                                                          |             
      Forestomach, Hyperkeratosis          | 1           1                 2           1                       1      |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           | 2                             2                                          |             
      Forestomach, Ulcer                   |                                  1                                2      |             
      Glandular, Cyst                      |                                  X                                       |             
      Glandular, Dysplasia                 |             1                                                            |             
      Glandular, Hyperplasia               |             2                    1     2                                 |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |    1        2  1     1           1     2                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Developmental Malformation           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    1  1  1  1  1  1  1  1  1  2        1  1  1     1  1  1     1        1|             
      Cortex, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Hypertrophy, Diffuse         |          4                                                               |             
      Cortex, Hypertrophy                  |                                              1                 1         |             
      Medulla, Hyperplasia                 |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  M  M  +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +        +                                                      |             
      Inflammation, Chronic Active         | 1                 1                                                      |             
      Necrosis                             |       3  2                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |    1  1                                                     1            |             
      Seminiferous Tubule, Mineralization  |          1                                                  1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Angiectasis                  |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mesenteric, Angiectasis              |    1           1     1           1     1     2  2  2     1     1         |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |    1           1  1  2                 1        1                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 1     1  1  1  1  1     1        1  1        1  1  1  1  1  1  1     1  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                   2                                                      |             
      Prepuce, Acanthosis                  |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Necrosis                    |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | 1  2  2  1  2  1  2  1  2        1           1  1     2  2              2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          1                                                               |             
      Mineralization                       |                                                                          |             
      Thalamus, Mineralization             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |    1                             1        1           1                 1|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Abscess                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Cortex, Mineralization               | 1  1                                                     1  1  1     1   |             
      Papilla, Mineralization              |          1                                                               |             
      Papilla, Necrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 8| 8| 8| 8| 8| 4| 8| 4| 0| 4| 8| 3| 8| 8| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Casts                  |             1              3                                             |             
      Renal Tubule, Degeneration           |                                                                         1|             
      Renal Tubule, Regeneration           | 1     1     2              2           1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6|            |
                                           | 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  A  +  M  M  M  +  M  +  +  M  M  M  +  +  +  M  M  +  +  M  +  +  M  M|  30        |
      Inflammation, Chronic Active         |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Lymphoid Nodule, Hyperplasia         |                         1        1                                       |      5  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +|  46        |
      Lymphoid Nodule, Hyperplasia         |    1        1  1              2  1                             1  1      |     21  1.1|
      Lymphoid Nodule, Necrosis            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Fatty Change, Focal                  | 1                                                                        |      7  1.1|
      Fibrosis                             |                1                                                         |      1  1.0|
      Hematopoietic Cell Proliferation     |       1                 3     1        2  1           1        1  1      |     14  1.2|
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization                       |    1                                1                                    |      3  1.0|
      Necrosis                             | 1  2  2     2  1  1                 2                             1     1|     12  1.4|
      Bile Duct, Hyperplasia               |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  48        |
      Acinus, Atrophy                      |                         1                                                |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Forestomach, Acanthosis              |                   2                                                      |      6  2.0|
      Forestomach, Cyst Epithelial         |                                                                          |            |
          Inclusion, Multiple              |                            X                                             |      1     |
      Forestomach, Hyperkeratosis          |                   2                                                  1   |      7  1.3|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      2  2.0|
      Forestomach, Ulcer                   |                                                                          |      2  1.5|
      Glandular, Cyst                      |                                                                          |      1     |
      Glandular, Dysplasia                 |                                                                          |      1  1.0|
      Glandular, Hyperplasia               |       1  1     2                                                         |      6  1.5|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |       2                                               1                  |      8  1.4|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6|            |
                                           | 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Capsule, Hyperplasia                 |       1        1        1     1  1  1  1  1  1        1        2  1      |     30  1.1|
      Cortex, Hyperplasia                  |          1              1                                                |      2  1.0|
      Cortex, Hypertrophy, Diffuse         |                                                                          |      1  4.0|
      Cortex, Hypertrophy                  |                                                                          |      2  1.0|
      Medulla, Hyperplasia                 |    1        1                       1                                    |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  M  M  +  M  M  +  +  M  +  M  +  M  M  M  +  M  +  M  M  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  M  M  +  +  +  M  M  +  +  +  +  +  +  M  +  +  M  +|  40        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +|  47        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +        +  +              +                          +|  10        |
      Inflammation, Chronic Active         |                            1  1              2                           |      5  1.2|
      Necrosis                             |                   2                          2                          1|      5  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  45        |
      Inflammation, Chronic Active         |                                              2  2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Seminiferous Tubule, Atrophy         |          1  1                          1                                 |      6  1.0|
      Seminiferous Tubule, Mineralization  |                                                                         1|      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +|  43        |
      Lumbar, Angiectasis                  |                                                                         1|      1  1.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                         1                                                |      1  1.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                         3                                                |      1  3.0|
      Mesenteric, Angiectasis              |       1           2  1     1                                             |     14  1.3|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6|            |
                                           | 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation                    |                   2  1  3              2                                 |     10  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Atrophy                              |                                                          1               |      1  1.0|
      Hematopoietic Cell Proliferation     | 1  1  2  1  1  2  1  3  4     2  1  2  3        1  2  2  1     1  3  1   |     38  1.4|
      Hyperplasia, Lymphoid                |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  M  M  +  M  M  +  +  +  +  M  +  M  +  M  +  M  M  M  +  M  M|  30        |
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Bacterium                            |                                        X              X                  |      2     |
      Hemorrhage                           |                                     1                                    |      1  1.0|
      Necrosis                             |                2     3        2     2  2           2              2      |      8  2.1|
      Prepuce, Acanthosis                  |                                                       2                  |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                                                       2                  |      1  2.0|
      Prepuce, Necrosis                    |                                                       1  2               |      2  1.5|
      Subcutaneous Tissue, Fibrosis        |                               2     2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Joint, Tarsal, Hyperostosis          |       1        1  2     1  1        1     1  2     2  2        1  1      |     27  1.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  48        |
      Inflammation, Acute                  |                         1                                                |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |                         1                                                |      1  1.0|
      Thalamus, Mineralization             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Abscess                              |                         2                                                |      1  2.0|
      Fungus                               |                         X                                                |      1     |
      Hemorrhage                           |          1                 1                                             |      7  1.0|
      Inflammation, Chronic Active         |                                     1                                    |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  M  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05053-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 4| 5| 7| 5| 6| 7| 7| 6| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 7| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 6|            |
                                           | 3| 4| 3| 8| 9| 8| 4| 6| 8| 8| 4| 4| 8| 6| 8| 8| 3| 9| 8| 0| 4| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                    +                           |   3        |
      Abscess                              |                         3                                                |      1  3.0|
      Fibrosis                             |                         3                                                |      1  3.0|
      Fungus                               |                         3                                                |      1  3.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Abscess                              |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                                                          1               |      2  1.5|
      Cortex, Mineralization               |       1                                   1     2        2               |     10  1.2|
      Papilla, Mineralization              |                                                                          |      1  1.0|
      Papilla, Necrosis                    |                                                          1               |      1  1.0|
      Renal Tubule, Casts                  |             1     1                                                      |      4  1.5|
      Renal Tubule, Degeneration           |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |             1     1                       1                              |      8  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------