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TDMS Study 05053-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/08/94   
EXP: 05053                        BROMOFORM                    TIME: 03:01:34   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55130    
CONT: N01ES2803301                                             CAS: 75-25-2     
PATHOLOGIST: K. MURTHY                                                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/08/94  
EXP: 05053                        BROMOFORM                    TIME: 03:01:34  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55130   
CONT: N01ES2803301                                             CAS: 75-25-2    
PATHOLOGIST: K. MURTHY                                                         

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE 46                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      455   544   588   629   642   688   694   713   721                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .05 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      163   393   507   532   602   629   656   669   670   673                 |
 |      678   688   692                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      438   483   509   526   530   565   570   623   632   634                 |
 |      646   663   664   679                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE 46 |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  94.0  90.0  82.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.05 G/KG 46|   100.0  98.0  98.0  98.0  96.0  96.0  92.0  90.0  86.0  74.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1 G/KG 46|   100.0 100.0 100.0 100.0 100.0  96.0  90.0  86.0  74.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE 46       .05 G/KG 46      0.1 G/KG 46   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.0%            74.0%            72.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.231          P=0.416          P=0.277       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       630.4            580.9            583.0         |
 |NATURAL DEATHS (C)      |       (29.5)           (42.6)           (20.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       712.1            691.2            688.8         |
 |(STANDARD ERROR)        |       ( 7.4)           (14.2)           (10.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE 46                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      502   565   584   587   600   600   600   605   616   623                 |
 |      624   642   643   645   682   685   692   694   698   699                 |
 |      701   718   722   726                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      490   494   495   497   521   523   538   541   542   545                 |
 |      553   558   561   565   566   568   576   584   590   591                 |
 |      597   601   614   628   633   650   656   659   667   673                 |
 |      674   677   688   706   715                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.2 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   359   372   440   447   470   537   537   545   554                 |
 |      560   564   565   566   567   575   583   604   609   616                 |
 |      622   635   639   649   658   671   671   672   680   719                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE 46 |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  83.7  71.4  51.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1 G/KG 46|   100.0 100.0 100.0 100.0 100.0 100.0  80.0  56.0  44.0  30.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.2 G/KG 46|   100.0 100.0 100.0  96.0  94.0  88.0  82.0  64.0  50.0  40.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE 46       0.1 G/KG 46      0.2 G/KG 46   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       51.0%            30.0%            40.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.081          P=0.006          P=0.097       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       643.9            592.5            566.3         |
 |NATURAL DEATHS (C)      |       (11.9)           (11.0)           (18.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       690.4            635.2            633.8         |
 |(STANDARD ERROR)        |       ( 8.7)           (12.1)           (16.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             BROMOFORM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE 46       = 1
                                                        .05 G/KG 46      = 2
                                                        0.1 G/KG 46      = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                         2                                          3  1
      |
      |                           2                                    2     3  1   3         1
      |                                                                2            3   2     1     1
P  95 +
E     |                                                                                 2   2       1      1
R     |                                                                                     2          2   1 1
C     |
E  90 +                                                                                     3    3     2   2 1       1
N     |
T     |                                                                                          33        2   2     11
      |                                                                                           3       3    2  2   1 1
S  85 +
U     |                                                                                                   3 3           11
R     |                                                                                                           22     1  1
V     |
I  80 +                                                                                                     3 3
V     |
A     |                                                                                                       3  3 2 2
L     |
   75 +
      |                                                                                                          3 3 2      2
      |                                                                                                            3        3
      |
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

                                                             BROMOFORM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE 46       = 1
                                                        0.1 G/KG 46      = 2
                                                        0.2 G/KG 46      = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                               3                            2 1
      |                                                 3        3                   221         1
      |                                                          3 3         3                   1  1
      |                                                                      33       2    2        1  1
   90 +                                                                       3    3
      |                                                                            3       2 2
P     |                                                                                      22        11
E     |                                                                                       3 3       111
R  80 +                                                                                       22          11
C     |                                                                                        223         1 1
E     |                                                                                         22
N     |                                                                                                      11     1
T  70 +                                                                                          223
      |                                                                                           223               11
S     |                                                                                            22 2 3            11
U     |                                                                                                 33
R  60 +                                                                                               22 33           11
V     |                                                                                                   3 3          1 1
I     |                                                                                                2 2 2333          11
V     |                                                                                                    22 33
A  50 +                                                                                                     2 23  3       1 1
L     |                                                                                                       22
      |                                                                                                        2 22 3
      |                                                                                                           223    3
   40 +                                                                                                                  3  3
      |
      |                                                                                                            2 2 2
      |                                                                                                                2 2
   30 +                                                                                                                  2  2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.