TDMS Study 05053-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05053 BROMOFORM TIME: 03:01:34
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55130
CONT: N01ES2803301 CAS: 75-25-2
PATHOLOGIST: K. MURTHY
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05053 BROMOFORM TIME: 03:01:34
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55130
CONT: N01ES2803301 CAS: 75-25-2
PATHOLOGIST: K. MURTHY
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 455 544 588 629 642 688 694 713 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .05 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 163 393 507 532 602 629 656 669 670 673 |
| 678 688 692 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 438 483 509 526 530 565 570 623 632 634 |
| 646 663 664 679 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 46 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 90.0 82.0 |
| | |
| | |
|.05 G/KG 46| 100.0 98.0 98.0 98.0 96.0 96.0 92.0 90.0 86.0 74.0 |
| | |
| | |
|0.1 G/KG 46| 100.0 100.0 100.0 100.0 100.0 96.0 90.0 86.0 74.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 46 .05 G/KG 46 0.1 G/KG 46 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.0% 74.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.231 P=0.416 P=0.277 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 630.4 580.9 583.0 |
|NATURAL DEATHS (C) | (29.5) (42.6) (20.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 712.1 691.2 688.8 |
|(STANDARD ERROR) | ( 7.4) (14.2) (10.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 46 |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 502 565 584 587 600 600 600 605 616 623 |
| 624 642 643 645 682 685 692 694 698 699 |
| 701 718 722 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 490 494 495 497 521 523 538 541 542 545 |
| 553 558 561 565 566 568 576 584 590 591 |
| 597 601 614 628 633 650 656 659 667 673 |
| 674 677 688 706 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 303 359 372 440 447 470 537 537 545 554 |
| 560 564 565 566 567 575 583 604 609 616 |
| 622 635 639 649 658 671 671 672 680 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 46 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 83.7 71.4 51.0 |
| | |
| | |
|0.1 G/KG 46| 100.0 100.0 100.0 100.0 100.0 100.0 80.0 56.0 44.0 30.0 |
| | |
| | |
|0.2 G/KG 46| 100.0 100.0 100.0 96.0 94.0 88.0 82.0 64.0 50.0 40.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 46 0.1 G/KG 46 0.2 G/KG 46 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 51.0% 30.0% 40.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.081 P=0.006 P=0.097 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 643.9 592.5 566.3 |
|NATURAL DEATHS (C) | (11.9) (11.0) (18.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.4 635.2 633.8 |
|(STANDARD ERROR) | ( 8.7) (12.1) (16.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BROMOFORM
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 46 = 1
.05 G/KG 46 = 2
0.1 G/KG 46 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 2 3 1 3 1
| 2 3 2 1 1
P 95 +
E | 2 2 1 1
R | 2 2 1 1
C |
E 90 + 3 3 2 2 1 1
N |
T | 33 2 2 11
| 3 3 2 2 1 1
S 85 +
U | 3 3 11
R | 22 1 1
V |
I 80 + 3 3
V |
A | 3 3 2 2
L |
75 +
| 3 3 2 2
| 3 3
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
BROMOFORM
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 46 = 1
0.1 G/KG 46 = 2
0.2 G/KG 46 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 221 1
| 3 3 3 1 1
| 33 2 2 1 1
90 + 3 3
| 3 2 2
P | 22 11
E | 3 3 111
R 80 + 22 11
C | 223 1 1
E | 22
N | 11 1
T 70 + 223
| 223 11
S | 22 2 3 11
U | 33
R 60 + 22 33 11
V | 3 3 1 1
I | 2 2 2333 11
V | 22 33
A 50 + 2 23 3 1 1
L | 22
| 2 22 3
| 223 3
40 + 3 3
|
| 2 2 2
| 2 2
30 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.