TDMS Study 05053-01 Pathology Tables
NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | Acinus, Adenoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Forestomach, Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Medulla, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | M + + + + M M + M M M + M M M + + + M + + M M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + M + + M + M M + + + + M M + + + + M + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + M + + + +| Leiomyosarcoma | X | Leukemia Mononuclear | | Polyp Stromal | X X | Polyp Stromal, Multiple | X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X | Mesenteric, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Lymphocytic | X | Epithelial Cell, Thymoma NOS | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + M + + + + + + M M +| Adenocarcinoma, Multiple | | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + A + + M M + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | Forestomach, Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Medulla, Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M + M M M M M + + + + + + M M M M + M M| 21 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X | 26 | Pars Distalis, Adenoma, Multiple | X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X | 4 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + M M M + + M + + + M + + M M + +| 34 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X X X X X X | 9 | Polyp Stromal, Multiple | | 1 | Sarcoma Stromal | X| 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lumbar, Leukemia Mononuclear | X | 2 | Mandibular, Leukemia Mononuclear | X X X X | 5 | Mediastinal, Leukemia Mononuclear | X X X | 4 | Mesenteric, Leukemia Mononuclear | X X X | 5 | Pancreatic, Leukemia Mononuclear | X X | 2 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Leukemia Mononuclear | X X X | 4 | Lymphoma Malignant Lymphocytic | | 1 | Epithelial Cell, Thymoma NOS | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +| 44 | Adenocarcinoma, Multiple | X | 1 | Fibroadenoma | X X X X X X X X| 14 | Fibroadenoma, Multiple | X X X X | 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Nose | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 45 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Large | + + + A + + A +| Polyp Adenomatous | | __________________________________________________________________________| Intestine Small | + + + + A + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X| Neoplastic Nodule | X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +| Acinus, Carcinoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + M + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + M + + + M M + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X | Pars Distalis, Adenoma, Multiple | X X | __________________________________________________________________________| Thyroid Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| C-Cell, Adenoma | X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M M + +| Adenoma | | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + +| Granulosa Cell Tumor | | Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Vagina | + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + M + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | Mesenteric, Leukemia Mononuclear | X X| Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Thymus | M + + M + M +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + + + + + M + + + M + + + + + + M +| Fibroadenoma | X X X X X X X X X X X X | Fibroadenoma, Multiple | | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + M + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + M + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + M + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Clitoral Gland| | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Nose | + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X| __________________________________________________________________________| Urinary Bladder | + M + A + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + +| 18 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + +| 16 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X | 13 | Neoplastic Nodule | X | 4 | __________________________________________________________________________|____________| Mesentery | + + | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Carcinoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + +| 26 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + +| 16 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + M + +| 18 | Leukemia Mononuclear | X X X X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + M M M +| 16 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 46 | Leukemia Mononuclear | X X | 2 | Pars Distalis, Adenoma | X X X | 10 | Pars Distalis, Adenoma, Multiple | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | C-Cell, Adenoma | X X | 3 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + | 9 | Adenoma | X | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + +| 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Granulosa Cell Tumor | X | 1 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X | 9 | __________________________________________________________________________|____________| Vagina | + | 2 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + +| 16 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Axillary, Leukemia Mononuclear | X X | 2 | Mandibular, Leukemia Mononuclear | X X X X X | 5 | Mediastinal, Leukemia Mononuclear | X X X X | 4 | Mesenteric, Leukemia Mononuclear | X X X X X | 7 | Pancreatic, Leukemia Mononuclear | X X X X | 4 | Renal, Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + +| 28 | Leukemia Mononuclear | X X X X X X X X | 13 | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + +| 14 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + M + + + + + + + + + + + + M + + + + +| 42 | Fibroadenoma | X X X X | 16 | Fibroadenoma, Multiple | X | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + +| 17 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + +| 32 | Alveolar/Bronchiolar Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Clitoral Gland| X | 1 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + | 12 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 7 | __________________________________________________________________________|____________| Urinary Bladder | + + + M + + + + + +| 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| Adenocarcinoma | X | Polyp Adenomatous | X X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Neoplastic Nodule | | Neoplastic Nodule, Multiple | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Acinus, Adenoma | X X | Acinus, Adenoma, Multiple | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pericardium, Alveolar/Bronchiolar | | Carcinoma, Metastatic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Medulla, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M M M M M + M M + M + M M + M + M + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + M + + + + + + + M + + +| Adenoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granulosa Cell Tumor | | Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X X | Mesenteric, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + M + + + M + + + + + + + + + + + +| Fibroadenoma | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Sarcoma | | Pelvis, Transitional Epithelium, | | Papilloma | X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + M M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenocarcinoma | X | 2 | Polyp Adenomatous | X X | 6 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 6 | Neoplastic Nodule | X | 1 | Neoplastic Nodule, Multiple | X | 1 | __________________________________________________________________________|____________| Mesentery | + | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Acinus, Adenoma | | 2 | Acinus, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | Pericardium, Alveolar/Bronchiolar | | | Carcinoma, Metastatic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Medulla, Pheochromocytoma Benign | X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + + M M M M + + M M M M M M M M M +| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X X X X X X X X X X X | 16 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X | 2 | Follicular Cell, Adenoma | X X | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + M M M + + + M + + + + + + + + + + +| 39 | Adenoma | X | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor | X | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Mandibular, Leukemia Mononuclear | | 1 | Mediastinal, Leukemia Mononuclear | | 2 | Mesenteric, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 6 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + M M M + + + M M + M M + + + + + + + + +| 39 | Fibroadenoma | X X | 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X| 5 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 4 | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Sarcoma | X | 1 | Pelvis, Transitional Epithelium, | | | Papilloma | | 1 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoid Nodule, Leukemia Mononuclear| | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X| Neoplastic Nodule | X X X| __________________________________________________________________________| Mesentery | + | Fat, Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Acinus, Adenoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Bilateral, Medulla, Pheochromocytoma | | Benign | X X | Medulla, Pheochromocytoma Benign | X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| Adenoma | X X | __________________________________________________________________________| Parathyroid Gland | M M + M + + M + + + + M M M + + + M M M M M M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Pars Distalis, Adenoma | X X X X X X X| Pars Distalis, Adenoma, Multiple | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + + + M + + + + + + + +| Adenoma | | Carcinoma | X X X | Leukemia Mononuclear | X| Bilateral, Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X| Tunic, Mesothelioma Benign | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | X| Mandibular, Leukemia Mononuclear | X X X X| Mediastinal, Hepatocellular | | Carcinoma, Metastatic | | Mediastinal, Leukemia Mononuclear | X X X X| Mesenteric, Leukemia Mononuclear | X X X| Pancreatic, Leukemia Mononuclear | X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M + M M M + M M M + M + + M M M M + M + M +| Fibroadenoma | X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Benign | X | Keratoacanthoma | X | Squamous Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Osteosarcoma | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Hepatocellular Carcinoma, Metastatic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic | | Leukemia Mononuclear | X X X X X| Squamous Cell Carcinoma, Multiple | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Squamous Cell Carcinoma, Metastatic, | | Skin | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Mesothelioma Benign | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + M| 47 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Leukemia Mononuclear | X | 1 | Lymphoid Nodule, Leukemia Mononuclear| X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X| 14 | Neoplastic Nodule | X | 4 | __________________________________________________________________________|____________| Mesentery | + + + | 4 | Fat, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Acinus, Adenoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| 48 | Leukemia Mononuclear | X X X | 6 | Bilateral, Medulla, Pheochromocytoma | | | Benign | X | 3 | Medulla, Pheochromocytoma Benign | X X X X X X X | 13 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Adenoma | X X| 4 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + M + M M M M M + + M M + M M M + M| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Pars Distalis, Adenoma | X X X X | 11 | Pars Distalis, Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + M M + + M + + + + +| 41 | Adenoma | X X X X| 4 | Carcinoma | X X | 5 | Leukemia Mononuclear | | 1 | Bilateral, Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| 33 | Interstitial Cell, Adenoma | X X X X X X X | 13 | Tunic, Mesothelioma Benign | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Axillary, Leukemia Mononuclear | X | 1 | Lumbar, Leukemia Mononuclear | X | 2 | Mandibular, Leukemia Mononuclear | X X X X | 8 | Mediastinal, Hepatocellular | | | Carcinoma, Metastatic | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X | 9 | Mesenteric, Leukemia Mononuclear | X X X | 6 | Pancreatic, Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 14 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + M M + + + + +| 47 | Leukemia Mononuclear | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M M M M + M M + + M M M M + M + + + M + + +| 20 | Fibroadenoma | X X| 4 | Fibroadenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Basosquamous Tumor Benign | X | 2 | Keratoacanthoma | | 1 | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | X X | 4 | Subcutaneous Tissue, Osteosarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Hepatocellular Carcinoma, Metastatic | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic | X | 1 | Leukemia Mononuclear | X X X X X X X| 12 | Squamous Cell Carcinoma, Multiple | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| 45 | Leukemia Mononuclear | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 14 | Mesothelioma Benign | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + M M + + + + + + + + M M + + + + + + M +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Neoplastic Nodule | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Acinus, Adenoma | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Bilateral, Medulla, Pheochromocytoma | | Benign | X | Medulla, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + M + + M M + M M + + M M M + M + M M M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X | Pars Distalis, Adenoma, Multiple | X X | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | Follicular Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Adenoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + M + M M + + M M + + + + M +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Adenoma | | Carcinoma | X X | __________________________________________________________________________| Prostate | + + + M + + + + M M + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | Tunic, Mesothelioma Benign | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X | Mesenteric, Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + M + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M + M M M M + M M M M M M M M M + M + M + M M| Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + I + + + + + + + + + +| Squamous Cell Carcinoma | X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Benign | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + + + + + M M + + + M M M M +| 36 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | Neoplastic Nodule | X X | 2 | __________________________________________________________________________|____________| Mesentery | + + + | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 2 | Acinus, Adenoma | X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Forestomach, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 6 | Bilateral, Medulla, Pheochromocytoma | | | Benign | | 1 | Medulla, Pheochromocytoma Benign | X X X X X X | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M M M + + M + M + M M M + M M M M + M + + M| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + M + + +| 48 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X| 10 | Pars Distalis, Adenoma, Multiple | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Mesothelioma Benign | X | 1 | __________________________________________________________________________|____________| Preputial Gland | M M + + + + + M + + M M + + + + + + + + + + + +| 38 | Adenoma | X X X| 3 | Carcinoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X| 41 | Interstitial Cell, Adenoma | X X | 4 | Tunic, Mesothelioma Benign | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + M + + + + M + + + + + + + + + + + + + + + +| 48 | Mandibular, Leukemia Mononuclear | X X X | 5 | Mediastinal, Leukemia Mononuclear | X X X| 5 | Mesenteric, Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | __________________________________________________________________________|____________| Thymus | + + + + + + + M M + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M + + M M + + M + + + M M + M M M + M M M| 15 | Fibroadenoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Carcinoma | | 1 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | X X X | 4 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Leukemia Mononuclear | X X X X X| 8 | __________________________________________________________________________|____________| Nose | + M + + + + + + + + M + + + + + + + + + M + + +| 46 | Carcinoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | Mesothelioma Benign | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + M M + M + + + + + + + + + + M M +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Mesentery | + +| Fat, Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X X | Acinus, Adenoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, Medulla, Pheochromocytoma | | Benign | X | Medulla, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X| __________________________________________________________________________| Parathyroid Gland | M + M M M M M M M M + M + M + M M + M + M M M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X | Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + M + + M M + + + + + + + + + + + +| Mesothelioma Malignant | X X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + M + + + + + +| Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | Tunic, Mesothelioma Malignant | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + M + + + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Lung | X | Carcinoma, Metastatic, Thyroid Gland | X | Mandibular, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mesenteric, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Thymus | + + + + + M + + M M + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + M + M M M + + M M M + M + + + M + M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Renal Tubule, Adenocarcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Lymphocytic | | Mesothelioma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + M + + + + + + + + M + + + + +| 42 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Polyp Adenomatous | X | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | | 2 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Bilateral, Medulla, Pheochromocytoma | | | Benign | X | 2 | Medulla, Pheochromocytoma Benign | X X | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M M M M M M + + + + + + + M M M M + M + + M| 18 | __________________________________________________________________________|____________| Pituitary Gland | + + M + + + + + + + M + + + + + + + + M + + + M +| 45 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | | 1 | Pars Distalis, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + M M + + + + + + + + + + M + + + + +| 47 | C-Cell, Adenoma | X X | 3 | C-Cell, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + M + + + + + + + +| 41 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Preputial Gland | M + + + + + + + + M + M + M + + + + M + +| 34 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| 29 | Interstitial Cell, Adenoma | X X X X | 8 | Tunic, Mesothelioma Malignant | X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Lung | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Mandibular, Leukemia Mononuclear | X X | 3 | Mediastinal, Leukemia Mononuclear | X X X | 4 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mesenteric, Leukemia Mononuclear | X X X | 4 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | M M M + + + + + + + + + + + + + + + + M + M + + +| 41 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05053-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:32:21 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + M M M M M M + M M M + M M M M M M M + M| 19 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X | 4 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + M + + + + + + +| 38 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | Renal Tubule, Adenocarcinoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | Lymphoma Malignant Lymphocytic | X | 1 | Mesothelioma Malignant | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------