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TDMS Study 05053-01 Pathology Tables

NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97
Route: GAVAGE                                                                                                     Time: 08:35:28




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|             
                                           | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                                          1               |             
      Colon, Fibrosis                      |    1                                                                     |             
      Colon, Necrosis                      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X     X  X  X  X           X     X  X  X  X           X  X  X  X|             
      Fatty Change, Diffuse                |                         2        2     1                    3           2|             
      Fatty Change, Focal                  |          1  1                 2                    1                     |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Chronic Active         |                      1           1                 1           1     1   |             
      Mixed Cell Focus                     |    X                                                                     |             
      Necrosis                             |    1                 1  3                    1                           |             
      Bile Duct, Hyperplasia               |                      1        1           1     1     1     1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +                                       |             
      Fat, Necrosis                        |                      3           1                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1     3  2                          1  2        1         |             
      Acinus, Hyperplasia                  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |             1           1              2                    2           1|             
      Forestomach, Hyperkeratosis          |             1           1     1        2                    2           1|             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                             1           1|             
      Forestomach, Ulcer                   |                               2                                         1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1     1  1     1     1     1  1  1  2  1  1  1  1     1  1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Cortex, Hyperplasia                  |                                        2                                 |             
      Medulla, Hyperplasia                 | 1                                   1  1        1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  M  +  M  M  M  +  M  M  M  +  +  +  M  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Angiectasis           | 1  2  3     3  1  2              3  1     2        1  2  2  3        1  1|             
      Pars Distalis, Cyst                  |             X  X     X                                         X         |             
      Pars Distalis, Hyperplasia           |          1                          2                          1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|             
                                           | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                1                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1                                               1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  M  +  +  M  +  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +|             
      Inflammation, Chronic Active         |       1                                                                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                    X                        |             
      Inflammation, Chronic Active         |                   2                                                      |             
      Mineralization                       |                                                 1                        |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Hemorrhage                           |                                        1                                 |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Mineralization                       |                                        1                                 |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Pigmentation            |                1                                         1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  2  1        1  2  1           1  2  3  1     1  1  2  2     1     1   |             
      Hemorrhage                           |                                                          2               |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                         3        1                          2     1     1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +|             
      Galactocele                          |    X  X  X  X  X  X  X  X        X  X     X     X              X        X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|             
                                           | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hemorrhage               |             2                                                     1      |             
      Cerebellum, Hemorrhage               |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                        1        1     1  1               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            1                 1                          1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1  1  1  1     2        1  2  2  1  1  1  1  2     2     1  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  A  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |    1                                                                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3|            |
                                           | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             |                      2  1  1              1                              |      5  1.2|
      Colon, Fibrosis                      |                                                                          |      1  1.0|
      Colon, Necrosis                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X        X        X  X  X     X  X     X  X  X                    X   |     28     |
      Fatty Change, Diffuse                |                   2                    1                       4         |      8  2.1|
      Fatty Change, Focal                  |    1     2     2           1  1                    1              1      |     11  1.3|
      Hepatodiaphragmatic Nodule           |                         X     X                                          |      3     |
      Hyperplasia, Multifocal              |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |                   3                       1              2     1         |      9  1.3|
      Mixed Cell Focus                     |       X  X           X        X                             X     X     X|      8     |
      Necrosis                             |          1        2                                1     2     1  1  1   |     11  1.4|
      Bile Duct, Hyperplasia               |    1  1        2     1  2  2     1     2     1  1                 1      |     17  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                +                              |   4        |
      Fat, Necrosis                        |          2                                2                              |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |                      1              2     1     1        1     1         |     12  1.4|
      Acinus, Hyperplasia                  | 1                                                        1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Acanthosis              |                                                                2         |      6  1.5|
      Forestomach, Hyperkeratosis          |                                                                2         |      7  1.4|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                1         |      3  1.0|
      Forestomach, Ulcer                   |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  2     1  1  1  1     1     1  1     1        1        1     1   |     34  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                         1|      1  1.0|
      Cortex, Hyperplasia                  |                                                                          |      1  2.0|
      Medulla, Hyperplasia                 |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3|            |
                                           | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  M  M  +  M  M  M  M  M  +  +  +  +  +  +  M  M  M  M  +  M  M|  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |    1  2  2  2           1        2        2     2  2     2     1  3      |     27  1.9|
      Pars Distalis, Cyst                  |    X                                X                                    |      6     |
      Pars Distalis, Hyperplasia           |    2  1  1                    2           2  1                           |      9  1.4|
      Pars Intermedia, Hyperplasia         |                                                    2                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                      1     1           1     1  1  1              1      |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  M  M  M  +  +  M  +  +  +  M  +  +  M  M  +  +|  34        |
      Inflammation, Chronic Active         |          2                                                               |      2  1.5|
      Necrosis                             |          2                                      1                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          X        X     X|      5     |
      Inflammation, Chronic Active         |                                              2                           |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Interstitium, Hyperplasia            |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Pigmentation            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                1         |      1  1.0|
      Hematopoietic Cell Proliferation     | 1  1  2  2  2        2  1        1  1     2  2  1     2  1  2  1  2  2  1|     35  1.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                    2                     |      1  2.0|
      Pigmentation                         | 2                                                              1         |      7  1.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5|            |
                             DAY ON TEST   | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3|            |
                                           | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |
      Galactocele                          | X           X  X              X  X  X  X                 X     X  X  X   |     25     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Brain Stem, Hemorrhage               |                                                                          |      2  1.5|
      Cerebellum, Hemorrhage               |                                                    3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |          1           1  1                          1     2     1        1|     11  1.1|
      Inflammation, Chronic                |                                                                      1   |      1  1.0|
      Inflammation, Chronic Active         |                                                          1               |      4  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  1  1  1  2        1  1  1  2  2  1     1  1  1  1     2  1  2  2  1   |     40  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         | 2                                                                        |      2  1.5|
      Necrosis                             | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|             
                                           | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +                             A  +        +        A  +|             
      Parasite                             |                                                                          |             
      Colon, Necrosis                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +              +              A  +                 A  +|             
      Lymphoid Nodule, Mineralization      |                                                                         1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X           X                    X        X           X        X|             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                        1              2     2           2|             
      Fatty Change, Focal                  |    1     1           2  1  1  1  1  2     1  1           2     1  1  1   |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                          2               |             
      Inflammation, Chronic Active         |                      1  1  1  1           2                       1      |             
      Mixed Cell Focus                     |    X        X  X     X  X  X  X  X  X  X  X  X        X     X     X      |             
      Necrosis                             |          1                                                  1     1      |             
      Bile Duct, Hyperplasia               |                1                 2        2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                       1  1               |             
      Acinus, Hyperplasia                  |                                        1                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Artery, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |       1                                                                  |             
      Duct, Inflammation, Chronic Active   |                                                                         1|             
      Duct, Metaplasia, Squamous           |                                                                         1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +     +     +  +     +        +     +  +        +        +  +|             
      Forestomach, Acanthosis              | 2                          2              1                 1            |             
      Forestomach, Hyperkeratosis          | 2                       2  1     2        1                 1            |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           | 2                                         1                              |             
      Forestomach, Ulcer                   | 2                                         1                              |             
      Glandular, Abscess                   |                                                                          |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Glandular, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|             
                                           | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +                             M  +                 +  +|             
      Cardiomyopathy                       | 1     1           1                                1                 1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +                             +  +                 +  +|             
      Necrosis                             |                   3                                                     1|             
      Medulla, Hyperplasia                 |                                                    1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M        +  M     +           +     +     M  M  +              +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    1                    1     2        2  1  2                       2   |             
      Pars Distalis, Cyst                  |          X     X                                            X  X         |             
      Pars Distalis, Hyperplasia           |    1           1     1        1           1           2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Necrosis                             |                               3                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       M           M                                M                 +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +        +                             +  +        +        +  +|             
      Cyst                                 |                                                             X            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +                             M  +                 +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +|             
      Lumbar, Pigmentation                 |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mesenteric, Depletion Lymphoid       |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|             
                                           | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +           +                       +     +  +  +     +  +     +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  1  2           2                       2        2        1  1         |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1                                               3              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +           +                             M  +                 M  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +|             
      Galactocele                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperkeratosis                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +                             M  +                 +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +                             +  +                 +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +     +  +     +  +     +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       1        1                             1     1                     |             
      Inflammation, Chronic Active         |                   1                          1                           |             
      Inflammation, Granulomatous          |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    |       +           +                                +                 +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Lens, Synechia                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Nephropathy                          | 4  1        1        1  2  1  1  1  2  1  1  1     1  2  1  2  1  2  1  1|             
      Transitional Epithelium, Hyperplasia |                   2              2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     M           +                             A  +                 +  +|             
      Mineralization                       |                   1                                                      |             
      Transitional Epithelium, Hyperplasia |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3|            |
                             DAY ON TEST   | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4|            |
                                           | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +     +        +     +        +     +  +     +        +  +  +|  18        |
      Parasite                             |                                  1                                       |      1  1.0|
      Colon, Necrosis                      |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +     +        +     +        +        +     +        +  +  +|  16        |
      Lymphoid Nodule, Mineralization      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |             X           X     X  X        X  X     X        X            |     15     |
      Cyst                                 |                                           X                    X         |      2     |
      Eosinophilic Focus                   |                         X     X                                          |      2     |
      Fatty Change, Diffuse                |       2  2  1  2     2     2              2     2                 2      |     13  1.8|
      Fatty Change, Focal                  | 1                       1     1  1  1  1     2     1  1     1  2     1   |     26  1.2|
      Hepatodiaphragmatic Nodule           |                                                          X               |      2     |
      Hyperplasia, Focal                   |                2                                                         |      1  2.0|
      Hyperplasia, Multifocal              |       2                                                                  |      2  2.0|
      Inflammation, Chronic Active         |                                        1     1                           |      8  1.1|
      Mixed Cell Focus                     | X  X  X              X              X  X     X  X     X        X         |     25     |
      Necrosis                             |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               |       2     2        1     2  1        1  2                              |     10  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +  +                           |   3        |
      Artery, Necrosis, Fibrinoid          |                                              2                           |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                              2                           |      1  2.0|
      Fat, Necrosis                        |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |    1  1     1                             1  2                           |      7  1.1|
      Acinus, Hyperplasia                  |                                                                2         |      2  1.5|
      Artery, Inflammation, Chronic Active |                                              1                           |      1  1.0|
      Artery, Necrosis, Fibrinoid          |                                              2              1            |      2  1.5|
      Artery, Pigmentation                 |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Ectasia                        |                                                                          |      1  1.0|
      Duct, Inflammation, Chronic Active   |                1  1  2     2              1     2                 1  1   |      9  1.3|
      Duct, Metaplasia, Squamous           |                1  1  1     1              1     1        1        1  1   |     10  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +     +     +  +     +        +     +  +     +        +  +  +|  26        |
      Forestomach, Acanthosis              |                         2                                         1  1   |      7  1.4|
      Forestomach, Hyperkeratosis          |                                                                      1  1|      8  1.4|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   2      |      3  1.7|
      Forestomach, Ulcer                   |                                                 2                 2      |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3|            |
                             DAY ON TEST   | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4|            |
                                           | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Abscess                   |                                                                      2   |      1  2.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                      2   |      1  2.0|
      Glandular, Necrosis                  |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +     +        +     +        +        +     +        +  +  +|  16        |
      Cardiomyopathy                       |                   1        1     2        1        1     1           1   |     12  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +     +        +     +        +     +  +     +     +  M  +  +|  18        |
      Necrosis                             |                                                                          |      2  2.0|
      Medulla, Hyperplasia                 |                                                 1              1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +  +  +     +  +     +        M  +     +     M        M  M  +|  16        |
      Hyperplasia                          |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  46        |
      Pars Distalis, Angiectasis           |                1           1                          1        2         |     11  1.5|
      Pars Distalis, Cyst                  |             X                       X        X                    X      |      8     |
      Pars Distalis, Hyperplasia           | 1  1           1           2     1  1  1     2                    2      |     15  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Necrosis                             |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |             1        1           1  1  1  1     1                        |      7  1.0|
      Follicular Cell, Cyst                |                                        X                                 |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             M           +  +     +        +        +              +  +   |   9        |
      Inflammation, Chronic Active         |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +     +        +     +        +        +     +  +     +  +  +|  20        |
      Cyst                                 |                                                                         X|      2     |
      Necrosis                             |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Decidual Reaction                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3|            |
                             DAY ON TEST   | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4|            |
                                           | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +     +        +     +        +        +     +        +  +  +|  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumbar, Pigmentation                 |             2                                                            |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                 2                        |      1  2.0|
      Mediastinal, Pigmentation            |                                  2        1                              |      2  1.5|
      Mesenteric, Depletion Lymphoid       |                                                                1         |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                 2           2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +  +     +     +        +     +  +     +  +  +  +  +  +|  28        |
      Depletion Lymphoid                   |                   2                                      1               |      2  1.5|
      Hematopoietic Cell Proliferation     |                1     1           1              2  2        2  2  1  1   |     17  1.5|
      Necrosis                             |                      2                                                   |      1  2.0|
      Pigmentation                         |                                  1                                   2  2|      6  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +     M        +     +        +        +     +     +  +  +  +|  14        |
      Infiltration Cellular, Lymphocyte    |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  42        |
      Galactocele                          | X                             X                       X              X   |      4     |
      Necrosis                             |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  46        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +     +        +     +        +        +     +        +  +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +     +        +     +        +        +     +        +  +  +|  17        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +     +        +  +  +        +  +     +     +        +  +  +|  32        |
      Infiltration Cellular, Histiocyte    |                                           1  1     1                    1|      8  1.0|
      Inflammation, Chronic Active         |                   1                          1                           |      4  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +              +     +        +        +              +  +   |  12        |
      Hemorrhage                           |                                                                      1   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3|            |
                             DAY ON TEST   | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4|            |
                                           | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                          +           +            |   3        |
      Lens, Cataract                       |                                                 X           X            |      2     |
      Lens, Synechia                       |                                                 1           2            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2  2  2  3  2  2     2  2  1  2  1  1  2  1  1  2     2     3  2     3  2|     41  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +     +        +     M        +        +     +        +  +  +|  14        |
      Mineralization                       |                   1                                                      |      2  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|             
                                           | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |          1                                         1                     |             
      Cecum, Inflammation, Acute           |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                       X  X  X           X  X     X  X  X   |             
      Clear Cell Focus                     |       X                                                                  |             
      Eosinophilic Focus                   |                                     X                                    |             
      Fatty Change, Diffuse                |       2        2  2              2     2  2  2        2  2  2  2  2  3   |             
      Fatty Change, Focal                  | 1  2     2  2        1     2  1     1           1  1                    1|             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Chronic Active         |       1  1                 1              1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |    X     X  X  X  X  X     X     X  X     X     X  X                    X|             
      Necrosis                             |                               2                                          |             
      Bile Duct, Hyperplasia               | 1                 1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                           |             
      Fat, Necrosis                        |                               3              1                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1     1  2                                                         |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                                               1                        |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                  1              2                 2      |             
      Duct, Inflammation, Chronic Active   |       2                          1     2  2  2        1     1  1  1  1   |             
      Duct, Metaplasia, Squamous           |       2                          1     1  2  2        1     2  2  1  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |          1        1                                            1         |             
      Forestomach, Hyperkeratosis          |                                                                2         |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                              1                           |             
      Forestomach, Ulcer                   |                                                                2         |             
      Glandular, Hyperplasia, Lymphoid     |                                                                   2      |             
      Glandular, Inflammation, Chronic     |                                                                          |             
          Active                           |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1              1  1        1  1  2                 1  1              1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|             
                                           | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Hyperplasia                  |                                                 1                        |             
      Medulla, Hyperplasia                 |                   1  1     1                                            1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  M  M  M  M  +  M  M  +  M  +  M  M  +  M  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2     2                                                           2|             
      Pars Distalis, Cyst                  |                X     X                                                   |             
      Pars Distalis, Hyperplasia           |                                        1     2        1              1   |             
      Pars Intermedia, Cyst                | X                                                                        |             
      Pars Intermedia, Hyperplasia         |                1                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +     +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                           2     2                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                1        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mandibular, Pigmentation             |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                                                                          |             
      Mediastinal, Pigmentation            |                                                                1         |             
      Mesenteric, Depletion Lymphoid       |                                                                          |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                                          |             
      Mesenteric, Pigmentation             |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|             
                                           | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                                                       1                  |             
      Pancreatic, Pigmentation             |                      1                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |    1  2  2  2  1  1  2     2        1  1  1  2  1  1  1        1  1  1  1|             
      Pigmentation                         |       2           1                 1  2  1  2     1  2  1  2  2  1  1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                   1      |             
      Cerebellum, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       1  1     1  1  1  1     1     1                 1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Bronchus, Metaplasia, Squamous       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              3                           |             
      Metaplasia, Squamous                 |                                                                      1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                               2                             2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                              +         |             
      Inflammation, Acute                  |                                                                          |             
      Synechia                             |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|             
                                           | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Cataract                       | X                                                                        |             
      Lens, Inflammation, Acute            |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +           +         |             
      Abscess                              |                                                                2         |             
      Duct, Metaplasia, Squamous           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Necrosis                             |                                        3                                 |             
      Nephropathy                          | 2  2  2  2  1  1  1  2     2        2  2  2  2  2  2  1  2  2  1     1  1|             
      Transitional Epithelium, Hyperplasia |                                        1                                 |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Osseous                         |                                        1                                 |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |                                        1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                                  |             
      Inflammation, Chronic Active         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3|            |
                                           | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite                             | 1              1     1  1                                   1            |      7  1.0|
      Cecum, Inflammation, Acute           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                               X                             X  X  X      |     13     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   | X                                                                        |      2     |
      Fatty Change, Diffuse                |    3     2        2                       3     2        2     2         |     20  2.2|
      Fatty Change, Focal                  | 1     1        2     1  1  1  1  1     2     1     1  1           2  1  1|     26  1.3|
      Hepatodiaphragmatic Nodule           |                                     X                                    |      2     |
      Hyperplasia, Diffuse                 |                                                 3                        |      1  3.0|
      Hyperplasia, Focal                   |                                                                   2      |      1  2.0|
      Hyperplasia, Multifocal              |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         | 1     1     1  1     1     1  1  1  1  1           1  1     1            |     27  1.0|
      Mixed Cell Focus                     | X     X  X  X  X  X  X  X  X        X  X           X  X     X           X|     28     |
      Necrosis                             |                               1                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 1                                                                    1   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   3        |
      Fat, Necrosis                        |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                                          |      3  1.3|
      Acinus, Hyperplasia                  |          1           1           1                                       |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                   1      |      3  1.0|
      Acinus, Hyperplasia                  |                               1                                          |      1  1.0|
      Duct, Ectasia                        |       2           1     1     2                             1            |      8  1.5|
      Duct, Inflammation, Chronic Active   |    2     1                                      2              1     2   |     15  1.5|
      Duct, Metaplasia, Squamous           |    2     1                                      2              1  1  2   |     16  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Acanthosis              |             2                                                            |      4  1.3|
      Forestomach, Hyperkeratosis          |             2  1  1                                                      |      4  1.5|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |             1                                                            |      2  1.0|
      Forestomach, Ulcer                   |                                                                          |      1  2.0|
      Glandular, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Glandular, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3|            |
                                           | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     1              2  1  2     1  1  1        1     1     1     1      |     22  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Hyperplasia                  |                            1  2                                          |      3  1.3|
      Medulla, Hyperplasia                 | 1           1              2                                             |      7  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  +  +  +  +  M  M  M  M  +  +  M  M  M  M  M  M  M  M  M  +|  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |             2  2                 3              2        3           2   |      9  2.2|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                               1                       1     1            |      7  1.1|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                               1                          1               |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  M  M  M  +  +  +  M  +  +        +  +  +  +  +  +  +  +  +|  39        |
      Inflammation, Chronic Active         |                                                    1  1                  |      2  1.0|
      Necrosis                             |                               3                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                                               X                  |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                 1                        |      1  1.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3|            |
                                           | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Plasma Cell                     |                                           2                    2     1   |      3  1.7|
      Mandibular, Pigmentation             |                                                                      1   |      1  1.0|
      Mediastinal, Congestion              |                                                 2                        |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                           1                              |      1  1.0|
      Mediastinal, Pigmentation            |    2                                      2     2              1     2   |      6  1.7|
      Mesenteric, Depletion Lymphoid       |          2        1                                                      |      2  1.5|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                   1      |      1  1.0|
      Mesenteric, Pigmentation             |                                                                          |      1  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      1  1.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                              1                    1      |      2  1.0|
      Hematopoietic Cell Proliferation     | 1  1     1  1     1  1     1     2  1  1  2  2  2  2  1  1  1  2  2  1   |     39  1.3|
      Pigmentation                         |    1  1  1  1        1     1           1  1  1     1  1     1  2  1  2   |     29  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Lymphocyte    |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  M  M  M  +  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +|  39        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                                                          |      1  1.0|
      Cerebellum, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1              2  1  1              1  1        1                        |     16  1.1|
      Inflammation, Chronic Active         |    2              1                                            1  3      |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3|            |
                                           | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |             1                                                            |      1  1.0|
      Bronchus, Metaplasia, Squamous       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |                                                                      1   |      2  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                3  2      |      2  2.5|
      Inflammation, Chronic Active         |    1                                                                     |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                    +         |   4        |
      Inflammation, Acute                  |                                           3                              |      1  3.0|
      Synechia                             |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                X         |      2     |
      Lens, Inflammation, Acute            |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +                    +         |   4        |
      Abscess                              |                                           4                    3         |      3  3.0|
      Duct, Metaplasia, Squamous           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Necrosis                             |                                              2                           |      2  2.5|
      Nephropathy                          | 2  1  1  3  2  1  2  2  1  2  2  3  1  2  2  3  3  2  1  2  2  2  2  1  2|     46  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Osseous                         |                                                                          |      1  1.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|             
                                           | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                2         |             
      Hemorrhage                           |                                                                1         |             
      Parasite                             |                                                          1               |             
      Cecum, Inflammation, Chronic Active  |                                                                          |             
      Colon, Hyperplasia, Lymphoid         |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X        X  X  X  X           X  X  X  X     X  X        X   |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |    1  3                                                                 2|             
      Fatty Change, Focal                  |          1        1  1     1           1  1     1     1  1  2            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                   2      |             
      Mixed Cell Focus                     |          X     X                 X                                       |             
      Necrosis                             |    2                 1                                1     2            |             
      Bile Duct, Hyperplasia               | 2  1     2  2  2     1  1  1  1  1  3     2  1  1  2  2  1  1     2  1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Artery, Necrosis, Fibrinoid          |                                  3                                       |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1              2                                                |             
      Acinus, Hyperplasia                  |                      1                                1                  |             
      Artery, Necrosis, Fibrinoid          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |                                                                          |             
      Forestomach, Hyperkeratosis          |    1                    1                                                |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |    1                    1           1                                    |             
      Forestomach, Necrosis                |    1                                                                     |             
      Forestomach, Ulcer                   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  2  2  1  1  1  1  2  2  2        2  1  1  1  2  1        1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Cortex, Hyperplasia                  |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|             
                                           | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Necrosis                     | 2                                                                        |             
      Medulla, Hyperplasia                 |       1  1  1        1     1        1              1  1           1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  +  M  +  +  +  +  M  M  M  +  +  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 1                 1                       2              2              2|             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hyperplasia           |          1  1           1  1                                   1         |             
      Pars Intermedia, Hyperplasia         |                                                                1         |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                 1                                                |             
      Capsule, Necrosis, Fibrinoid         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  M  +  +  +  +  +  +  +     +  M  +  +  +  +  +     +  +  +|             
      Fibrosis                             |          1                                                               |             
      Inflammation, Chronic Active         |          2           2        1                 1                        |             
      Mineralization                       |                                                                          |             
      Necrosis                             |             2              2                                2     2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       2                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 1     2     1     1                       1     1     2  1           2   |             
      Metaplasia, Squamous                 |       1                                               1                  |             
      Epithelium, Hyperplasia              |                                                       1                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 1  1  1  1           1  1  1  1           1        1  1     1  1  1  1  1|             
      Seminiferous Tubule, Atrophy         | 2     1     2  1     1  1  2  1  1  2     1  1  1  2  2  1  1     1  1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Pigmentation                 |       2                                                                  |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Hemorrhage              |                   1                                                      |             
      Mediastinal, Pigmentation            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|             
                                           | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Angiectasis              |                                                                          |             
      Pancreatic, Angiectasis              |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1     1  1           1  2     1  1        1     1  3  1  2  1  3  1  1   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                               2  2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  M  M  M  +  M  M  M  +  M  +  +  M  M  M  M  +  M  +  M  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                2                                                         |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                       2                  |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                                                                          |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1        1                                                     2      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            2  1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|             
                                           | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 2     2  2  2  2  1  2  2  3  3  2  2     3  2  2  2  3  2  3  1  3  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                1         |             
      Transitional Epithelium, Hyperplasia |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4|            |
                                           | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Parasite                             |       1                                                                  |      2  1.0|
      Cecum, Inflammation, Chronic Active  |                                                          3               |      1  3.0|
      Colon, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X              X           X     X  X  X     X  X  X  X     X     X|     28     |
      Eosinophilic Focus                   |                                                             X            |      1     |
      Fatty Change, Diffuse                |    2                                            2                        |      5  2.0|
      Fatty Change, Focal                  |             1     1  1  2     1           1                    1        2|     18  1.2|
      Hyperplasia, Focal                   |    2           2                                                         |      2  2.0|
      Hyperplasia, Multifocal              |                                                                         2|      2  2.0|
      Mixed Cell Focus                     |             X  X  X     X  X                                   X     X   |     10     |
      Necrosis                             |          2                                1        1                     |      7  1.4|
      Bile Duct, Hyperplasia               | 1        2  2  2  2  1  1  1  1  2  1     1  1     1  1     2     2     1|     39  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                                  +                  |   4        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic Active    | 2                                                                        |      1  2.0|
      Fat, Necrosis                        | 2                                                     1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                               1  2  2     1                              |      6  1.5|
      Acinus, Hyperplasia                  |                   1                                                  1   |      4  1.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Forestomach, Acanthosis              |                                                                         3|      1  3.0|
      Forestomach, Hyperkeratosis          |    1                 1  2                                               3|      6  1.5|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                         1|      4  1.0|
      Forestomach, Necrosis                |    1                                                                    1|      3  1.0|
      Forestomach, Ulcer                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2  1  1     2  2     2  2  2  1  1  2     2  1  1  2  1  2  1  1  1|     42  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4|            |
                                           | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  48        |
      Thrombosis                           |                      1                                                   |      1  1.0|
      Cortex, Hyperplasia                  |                                                             1  1         |      3  1.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Medulla, Hyperplasia                 | 1     1  1     1        1  1     1  1  1           1        1     1      |     21  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Hyperplasia                          |                1                          1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  +  +  +  M  +  M  M  M  M  M  +  +  M  M  +  M  M  M  +  M|  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 2        1           2  3                       3           2            |     11  1.9|
      Pars Distalis, Cyst                  |             X                                                            |      2     |
      Pars Distalis, Hyperplasia           | 1        2  1                                               1            |      9  1.1|
      Pars Intermedia, Hyperplasia         |                      2                                                   |      2  1.5|
      Pars Nervosa, Cyst                   |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                                                      1   |      3  1.0|
      Capsule, Necrosis, Fibrinoid         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M     +  +  M  +  +  +  +  +|  41        |
      Fibrosis                             |                                                                      2   |      2  1.5|
      Inflammation, Chronic Active         |             1              2                                         2   |      7  1.6|
      Mineralization                       |          1                                                               |      1  1.0|
      Necrosis                             |          2        2                                               2      |      7  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                      1   |      2  1.5|
      Inflammation, Acute                  |                                                 4                        |      1  4.0|
      Inflammation, Chronic Active         | 2     2                 2        1                    2  3           1   |     16  1.6|
      Metaplasia, Squamous                 |                                                                          |      2  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4|            |
                                           | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |    1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1   |     37  1.0|
      Seminiferous Tubule, Atrophy         | 1  1  1  1  1  1  2  1     2     3  1     1  2     1  1     1  1  1  2  1|     40  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
      Mediastinal, Angiectasis             |                      1                          2                        |      2  1.5|
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |                                                       2                  |      2  1.5|
      Mesenteric, Angiectasis              |                      2                                                   |      1  2.0|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1     2     1        2     1     2     2  2  1     2  1     1  1        1|     30  1.4|
      Pigmentation                         |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +|  47        |
      Epithelial Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  +  M  M  +  +  M  M  M  M  +  M  +  +  +  M  +  +  +|  20        |
      Galactocele                          |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                         X                                                |      1     |
      Hyperkeratosis                       | 2                                                                        |      2  2.0|
      Necrosis                             |                                                          4              2|      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Tarsal, Hyperostosis          |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchiectasis                       |                      1                                                   |      1  1.0|
      Edema                                |                                                 1        1               |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4|            |
                                           | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    46 VM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    | 1     1           1  2           1                                       |      8  1.3|
      Inflammation, Acute                  |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |                                                    2                     |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           2                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    X                     |      1     |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Nephropathy                          | 2  2  1  2  3  1  2  2  1  2  1  1  1     1  2  1  3  1     1  2  3  2  3|     46  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                 2        3               |      3  2.0|
      Inflammation, Chronic Active         |                                                 2                        |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|             
                                           | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |             1                             1        1                     |             
      Lymphoid Nodule, Hyperplasia         |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X           X           X  X     X  X        X  X     X         |             
      Clear Cell Focus                     |                                                                      X   |             
      Degeneration, Cystic                 |                                                                         1|             
      Eosinophilic Focus                   |          X                       X  X        X        X        X        X|             
      Fatty Change, Diffuse                | 1  2           2  1     3     2                          2  2     2      |             
      Fatty Change, Focal                  |       1  2  1        2     1     1  2  1  1  1  1  2  2        1     1  1|             
      Focal Cellular Change                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                   2                                                      |             
      Hyperplasia, Multifocal              | 3                             2                                          |             
      Inflammation, Chronic Active         |    1  1  1  1        1  1           1  1  1     1     1  1     1     1  1|             
      Mixed Cell Focus                     |             X                 X        X        X                        |             
      Necrosis                             | 2                                                        1               |             
      Bile Duct, Hyperplasia               | 1  1  1  1  1        1  2  1  1  1  1  1     2  1  1  1        1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                1                                1           2           1|             
      Acinus, Hyperplasia                  |             1              1                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Fibrosis                             |                                                          2               |             
      Inflammation, Chronic Active         |                      1                                1                  |             
      Duct, Ectasia                        | 2  2           2                                      1                  |             
      Duct, Inflammation, Chronic Active   | 1  1           1  2     1     2                          1        1      |             
      Duct, Metaplasia, Squamous           | 1  1           1  2  1  2     2                          1        1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Acanthosis              |                                                                          |             
      Forestomach, Fibrosis                |                                                                   2      |             
      Forestomach, Hyperkeratosis          |    1                    2     1                          2  1            |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                               1                             1            |             
      Forestomach, Ulcer                   |                               2                                   2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  1  1  1     1        1  1  2  1        1  1     2  2     1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|             
                                           | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Cortex, Hyperplasia                  |                                                       1                  |             
      Cortex, Necrosis                     |                   1                                                      |             
      Medulla, Hyperplasia                 |    1                    2  1           1  1     1  1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                       2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  +  M  M  +  +  M  M  M  +  M  +  M  M  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3                                2           1        1           1   |             
      Pars Distalis, Cyst                  |                               X                    X                     |             
      Pars Distalis, Hyperplasia           | 1           1  1  2  1  1  2        1     2  1  1  1  1  1     1  2  1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                                     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  M  +  +  +  +  M  +|             
      Inflammation, Chronic Active         |    1  1  2                          1           1                       1|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2           2                                                         |             
      Inflammation, Chronic Active         |    3           2  1  1        1        1  1        1        3  1         |             
      Metaplasia, Squamous                 |    2           2                       1                                 |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                  1                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  1  1  1  1  1  1     1        1  1  1  1  1  1  1     1  1  1  1  1  1|             
      Seminiferous Tubule, Atrophy         |       1  2  1     1  1  1  1  1  1  2  1  2  1  1     1  1     1  1  1  1|             
      Seminiferous Tubule, Giant Cell      |                   1                                      1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                      2                                                   |             
      Mandibular, Necrosis                 |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|             
                                           | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                                                             1            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Fibrosis                             | 1                                                                        |             
      Hematopoietic Cell Proliferation     | 1  1  2  1     3     1  1  2     1  2  1  2  1  1  2  1  1  2        1  1|             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperkeratosis                       |                                                       3                  |             
      Inflammation, Chronic Active         |                                                       1                  |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Artery, Thrombosis                   |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     1                                    |             
      Infiltration Cellular, Histiocyte    | 1                                         1     1        1              1|             
      Inflammation, Chronic Active         |    1                          2                             1     2      |             
      Mineralization                       |                                                 1                        |             
      Alveolar Epithelium, Hyperplasia     |       2                       1                                   1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1           1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                             +  +                           |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|             
                                           | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |                            2                                             |             
      Nephropathy                          | 1  1  2  1  2  1  1  1  1  2  1  1  1  1  2  1  1  2  1  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3|            |
                                           | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  M  M  +|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite                             |                                                    1  1                  |      5  1.0|
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X        X           X  X     X     X     X     X  X  X            |     20     |
      Clear Cell Focus                     |                                              X                           |      2     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |       X                                   X                              |      9     |
      Fatty Change, Diffuse                |                   2  2           2                       1               |     13  1.8|
      Fatty Change, Focal                  | 2  1  2  1  2  1        1  2  1     1  1  1  1  1  1  1     1     1  1  1|     36  1.3|
      Focal Cellular Change                |                                                                      X   |      1     |
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |       1  1  1     1  1  1  1  1     1        1        1  1  1     1      |     29  1.0|
      Mixed Cell Focus                     |    X           X  X  X              X                             X  X   |     11     |
      Necrosis                             |          1                                                               |      3  1.3|
      Bile Duct, Hyperplasia               | 1  1  1  1     1     1  1     1           1  1  1  1  1  1  1  2  1  1  2|     37  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +  +           +            |   4        |
      Fat, Inflammation, Chronic Active    |                                                             1            |      1  1.0|
      Fat, Necrosis                        |                                              2  2           2            |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                         2        1  1              1                    1|      9  1.2|
      Acinus, Hyperplasia                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Duct, Ectasia                        |                                                                      1   |      5  1.6|
      Duct, Inflammation, Chronic Active   | 1                                1     2        2        1           1   |     14  1.3|
      Duct, Metaplasia, Squamous           | 1                                1     2        2        1           1   |     15  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Acanthosis              |                   3                                                      |      1  3.0|
      Forestomach, Fibrosis                |             1                                                            |      2  1.5|
      Forestomach, Hyperkeratosis          |             1     2        1                                             |      8  1.4|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |             1     4                                                      |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3|            |
                                           | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Ulcer                   |             2     3              1                                       |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  1     2  2  2  1  1        1  1  2  2     2  2  1  2  2  1  1  1|     39  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                                                                  |      2     |
      Cortex, Hyperplasia                  |                                                                          |      1  1.0|
      Cortex, Necrosis                     |                                                                          |      1  1.0|
      Medulla, Hyperplasia                 |                1        2  1                 1  1  1  1     1  1         |     16  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         1                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  M  M  +  +  M  +  M  +  M  M  M  +  M  M  M  M  +  M  +  +  M|  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Pars Distalis, Angiectasis           |             1              2     1           3  1     1                 1|     12  1.5|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |       1     1  1  1     1        1  2              1  1                  |     26  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                               1                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  M  +  +  +  +  +  M  +  +  M  M  +     +  +  +  +  +  +  +  +  +  +  +|  38        |
      Inflammation, Chronic Active         |                   1        2              1                    1  1      |     11  1.2|
      Necrosis                             |       3        3                                            2            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Fibrosis                             |    1                             1                                       |      4  1.5|
      Inflammation, Chronic Active         |    1  2                       1  2              2           2        2   |     17  1.6|
      Metaplasia, Squamous                 |                               1  2                                   1   |      6  1.5|
      Mineralization                       |                                                             2            |      1  2.0|
      Epithelium, Hyperplasia              |                                                    1                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spermatocele                         |                                           X                              |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3|            |
                                           | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1  1  1  1  1  1        1        1     1  1  1  1  1        1  1  1  1  1|     39  1.0|
      Seminiferous Tubule, Atrophy         | 2  1  1  1     1  1  1  1  1  1  1  1     3        1        2  2  1     1|     38  1.2|
      Seminiferous Tubule, Giant Cell      |             1                             1                    1        1|      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                  2     1                 1               |      4  1.5|
      Mandibular, Necrosis                 |                                                                          |      1  1.0|
      Mediastinal, Congestion              |                                     1                                    |      1  1.0|
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                           2                              |      2  1.5|
      Hematopoietic Cell Proliferation     | 2  1           1  1  2  1  2  1  1  2     1           1  1  1  1  1      |     36  1.3|
      Pigmentation                         |                1                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  +  +  M  M  +  +  M  +  +  +  M  M  +  M  M  M  +  M  M  M|  15        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                         X|      1     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                  2                                      2|      3  1.7|
      Subcutaneous Tissue, Necrosis        |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        1                             2   |      2  1.5|
      Artery, Thrombosis                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                        2                 1               |      3  1.3|
      Infiltration Cellular, Histiocyte    |                            1              1        1           1         |      9  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3|            |
                                           | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 LM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                  2        1  2                           |      7  1.6|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    2                             1        1                              |      6  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  M  +  +  +|  46        |
      Inflammation, Chronic Active         |                                                                      1   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          X                                                               |      1     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  2  3  1  1  1  2  2  2  2  2  1  1  2  1  1  1  2  2  3  2  3  1  1|     50  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|             
                             DAY ON TEST   | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|             
                                           | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Parasite                             |    1                                                                     |             
      Colon, Erosion                       |                                                       2                  |             
      Lymphoid Nodule, Hyperplasia         |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Fibrosis                      |                1                                                         |             
      Ileum, Necrosis                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X     X           X     X  X           X  X        X        X|             
      Eosinophilic Focus                   |    X                                                                 X   |             
      Fatty Change, Diffuse                |       2  2  2  2  3  3     3     3  2  2     3     3  2        3        3|             
      Fatty Change, Focal                  | 2  1                    1     1           2     2        1  1     2  1   |             
      Inflammation, Chronic Active         | 1  2  1     2     2  1                 2  1  1  1  1  1        1     1  1|             
      Mixed Cell Focus                     |          X           X                          X                        |             
      Necrosis                             |    1  1  1        1     1              2           1                 1   |             
      Bile Duct, Hyperplasia               |          1        1  2        1           2     1              1     2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +              +|             
      Fat, Necrosis                        |                                                                         1|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                     1                                    |             
      Acinus, Hyperplasia                  | 1                                                                        |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                    1                     |             
      Inflammation, Chronic Active         |                                        1           1                     |             
      Duct, Inflammation, Chronic Active   |       1  1        1     2  2        1        2  2     1  1     2        1|             
      Duct, Metaplasia, Squamous           |       2  2  1     1  1  1  1        2  2     1  2  3  1  1     2        2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperkeratosis          |          2                             1                                 |             
      Forestomach, Hyperplasia, Basal Cell |                         1     2        2                                 |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |          1           1           2     2     1                          2|             
      Forestomach, Ulcer                   |       2                          2                 2  2  2     1        2|             
      Glandular, Necrosis                  |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1     1        1                 1  1     1  1  1     1  1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|             
                             DAY ON TEST   | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|             
                                           | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cortex, Hypertrophy, Focal           |                                                                      1   |             
      Cortex, Necrosis                     |                                                                          |             
      Medulla, Hyperplasia                 | 1  1                                   2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  M  M  M  M  +  M  +  M  +  M  M  +  M  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Angiectasis           |                                           1                              |             
      Pars Distalis, Hyperplasia           | 1        2  1                       1     1     2  1  2                  |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             1                                                            |             
      Necrosis                             |             1                                                            |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  M  +  +  M  M  +     +  +  +  +  +  +  +     +  +     +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +        +     +  +  +  +  M  +  +     +  +     +  +|             
      Inflammation, Chronic Active         |       1           2           1        1                             1   |             
      Necrosis                             | 1  2                 1                    2  1        2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            1           1           1           1         |             
      Inflammation, Chronic Active         |    1  1     2     2  1     4  1     1        3     1     2     1     2  1|             
      Metaplasia, Squamous                 |       1     1     2  1     1           2     1     3           1         |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                                           1  1                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  1  1  2  1     1     1  1  1     1  1  1  1  1  2  1  1        1     1|             
      Seminiferous Tubule, Atrophy         | 1     1  1  1     1  1        3        2  1     1           1  1     1  1|             
      Seminiferous Tubule, Giant Cell      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Angiectasis             |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|             
                             DAY ON TEST   | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|             
                                           | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Congestion              |                   1                                                      |             
      Mediastinal, Depletion Lymphoid      |                   1                                                      |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |             2                 2     2     1           1                 1|             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Mast Cell                       |                         1                                1               |             
      Pancreatic, Pigmentation             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                1        1                                      1         |             
      Hematopoietic Cell Proliferation     | 1  1  1  1  1     1  1  1     2     2  1  1     2  1  1           1  1  2|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  M  +  M  M  M  +  +  M  M  M  +  M  +  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Vacuolization Cytoplasmic|                                        1                                 |             
      White Matter, Cerebrum,              |                                                                          |             
          Vacuolization Cytoplasmic        |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                                     3                                    |             
      Infiltration Cellular, Histiocyte    |          1           1     1     1        1                    2         |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Chronic Active         |                1  1     2     1  1        1                 2     2      |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |    2                                   1                                 |             
      Bronchiole, Inflammation, Acute      |             2           1  1                                             |             
      Bronchus, Metaplasia, Squamous       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +     +  +        +     +  +  +  +  +  +  +     +  +     +  +|             
      Inflammation, Chronic Active         |          1                                2                          2   |             
      Metaplasia, Squamous                 |                                           2                              |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|             
                             DAY ON TEST   | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|             
                                           | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.2 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Necrosis                             |                      1                                                   |             
      Nephropathy                          | 1  1  1  1  1  1  2  2  1  1     1  1  1  1     2  1  1  1  2  2     1  2|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Pelvis, Inflammation, Acute          |                         1                                                |             
      Renal Tubule, Degeneration           |                                              2                           |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                1                                                         |             
      Necrosis                             |                         3                                                |             
      Transitional Epithelium, Hyperplasia |                1           1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6|            |
                             DAY ON TEST   | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0|            |
                                           | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |       1                                                                  |      1  1.0|
      Parasite                             |    1              1                                                  1  1|      5  1.0|
      Colon, Erosion                       |                                                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ileum, Fibrosis                      |                                                                          |      1  1.0|
      Ileum, Necrosis                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X  X     X  X     X     X     X     X                          X  X|     24     |
      Eosinophilic Focus                   |                                           X        X                     |      4     |
      Fatty Change, Diffuse                |    3           4           3  3  3     2     2  3     2     3  3  2      |     27  2.6|
      Fatty Change, Focal                  | 2     1  2  1     2  1  2           2     2        2     2           2  2|     23  1.6|
      Inflammation, Chronic Active         |                   1        2  2     1     1        1  2     1            |     23  1.3|
      Mixed Cell Focus                     | X        X           X     X                          X                  |      8     |
      Necrosis                             |    1  1     2  1     1  1     1                 1  1  1     1  1         |     20  1.1|
      Bile Duct, Hyperplasia               | 1  1     1     1  2  1  1  1  1     1     1        1                    1|     22  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   3        |
      Fat, Necrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                    1                    1|      3  1.0|
      Acinus, Hyperplasia                  |                               1                                   1      |      3  1.0|
      Artery, Thrombosis                   |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  48        |
      Atrophy                              |                                           1                              |      1  1.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                           1                              |      3  1.0|
      Duct, Inflammation, Chronic Active   | 1        2                 1     2     2        1           1  1  1     1|     22  1.4|
      Duct, Metaplasia, Squamous           | 1  2  1  2        1        2  1  2     2  1     1           1  1  2     1|     31  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Hyperkeratosis          |                                           1                    1         |      4  1.3|
      Forestomach, Hyperplasia, Basal Cell |                                                                          |      3  1.7|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |                2                       1                    1     1      |     10  1.4|
      Forestomach, Ulcer                   | 1                                               1              2         |     10  1.7|
      Glandular, Necrosis                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6|            |
                             DAY ON TEST   | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0|            |
                                           | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1  1  1  1  1  1        1     1        1           1        2|     23  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Hypertrophy, Focal           |                                                                          |      1  1.0|
      Cortex, Necrosis                     |       1                                                                  |      1  1.0|
      Medulla, Hyperplasia                 |                      1                             1              1      |      6  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  M  M  M  M  M  +  +  +  +  +  +  +  M  M  M  M  +  M  +  +  M|  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  45        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    2        1     2        1     1                    1           1      |     15  1.3|
      Pars Nervosa, Cyst                   |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Follicle, Cyst                       |             X                                                            |      1     |
      Follicular Cell, Hyperplasia         |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  M     +  +  +  +  +  +  +  +|  41        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  M  +     M     +  M     +  +     +  +  M  +  +|  34        |
      Inflammation, Chronic Active         |                2        2                                   1        1  1|     10  1.3|
      Necrosis                             |                         2                                                |      7  1.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            2                                             |      5  1.2|
      Inflammation, Chronic Active         | 4                    3     2  1                                   2      |     19  1.8|
      Metaplasia, Squamous                 | 1                    2                                            1      |     12  1.4|
      Mineralization                       |                                                                   1      |      1  1.0|
      Epithelium, Hyperplasia              |                                                             1            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6|            |
                             DAY ON TEST   | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0|            |
                                           | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Spermatocele                         |    X                                                                     |      1     |
      Interstitial Cell, Hyperplasia       | 1  1  1  1  1  1  1        1     1     1  1  1     1  1  1  1  1  1  2  1|     39  1.1|
      Seminiferous Tubule, Atrophy         |    1  1  1  1  1  1  1  1  1  1     1     1        1  1  3  1  3     1  2|     33  1.2|
      Seminiferous Tubule, Giant Cell      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumbar, Pigmentation                 |    3                                                                     |      1  3.0|
      Mediastinal, Angiectasis             |                                           1                             1|      3  1.0|
      Mediastinal, Congestion              |                                                                          |      1  1.0|
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  1.0|
      Mediastinal, Hemorrhage              |                                                                      1   |      1  1.0|
      Mediastinal, Pigmentation            |    1        2                             1                 1        1  1|     12  1.3|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Mast Cell                       |                                                                          |      2  1.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                        1                                 |      4  1.0|
      Hematopoietic Cell Proliferation     | 1  1     1  1  1  1  2  1  1  1     2        2     1  1     1  1     1   |     35  1.2|
      Infarct                              | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  +  M|  19        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        1                                 |      1  1.0|
      Necrosis                             |                                  2     2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Brain Stem, Vacuolization Cytoplasmic|                                                                   1      |      2  1.0|
      White Matter, Cerebrum,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                   1      |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05053-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             BROMOFORM                                         Date: 05/06/97  
Route: GAVAGE                                                                                                     Time: 08:35:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6|            |
                             DAY ON TEST   | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0|            |
                                           | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.2 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     46 HM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchiectasis                       |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1     1        1     1                          1     2           1      |     13  1.2|
      Inflammation, Acute                  |                   2                                                      |      2  2.0|
      Inflammation, Chronic Active         |    1     1                             1  1     1     2     1            |     15  1.3|
      Inflammation, Granulomatous          | 2                                                                        |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |             2                 2                                          |      4  1.8|
      Bronchiole, Inflammation, Acute      |                                                                          |      3  1.3|
      Bronchus, Metaplasia, Squamous       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  M     +  +     +  +  +  +  +|  38        |
      Inflammation, Chronic Active         |                                                                      1   |      4  1.5|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                +                           |   2        |
      Inflammation, Chronic Active         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                X         |      1     |
      Fibrosis                             |                                                                   1      |      1  1.0|
      Hydronephrosis                       |                                              1                           |      1  1.0|
      Necrosis                             |                                                                   2      |      2  1.5|
      Nephropathy                          | 2  1  2  1  1  1  1  2  2  1  1  1  1     1  2  2  1  1     1  2  1  2  1|     45  1.3|
      Artery, Necrosis, Fibrinoid          |                                     1                                    |      1  1.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  1.0|
      Renal Tubule, Degeneration           |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              4                    1      |      2  2.5|
      Inflammation, Chronic Active         |                                                                   1      |      2  1.0|
      Necrosis                             |                                              4                    1      |      3  2.7|
      Transitional Epithelium, Hyperplasia |                                                                   1      |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------