National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1837

TDMS Study 05053-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/08/94   
EXP: 05053                        BROMOFORM                    TIME: 01:18:09   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55130    
CONT: N01ES2803301                                             CAS: 75-25-2     
PATHOLOGIST: K. MURTHY_____                                                     
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/08/94  
EXP: 05053                        BROMOFORM                    TIME: 01:18:09  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 55130   
CONT: N01ES2803301                                             CAS: 75-25-2    
PATHOLOGIST: K. MURTHY_____                                                    

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE 46                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      198   377   429   483   491   514   524   575   586   610                 |
 |      611   621   632   658   679   688                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      337   537   600   607   621   622   629   632   642   649                 |
 |      649   659   660   663   679   680   694   714   714   721                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.2 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      229   236   250   275   299   303   303   356   363   393                 |
 |      499   527   533   591   600   601   603   616   636   638                 |
 |      639   642   642   642   643   644   649   649   664   665                 |
 |      666   670   670   672   687   714   715   716   723                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE 46 |   100.0 100.0  98.0  98.0  96.0  92.0  86.0  82.0  72.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1 G/KG 46|   100.0 100.0 100.0  98.0  98.0  98.0  96.0  94.0  72.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.2 G/KG 46|   100.0 100.0  94.0  82.0  80.0  80.0  74.0  66.0  40.0  22.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE 46       0.1 G/KG 46      0.2 G/KG 46   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%            60.0%            22.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.771          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       542.3            635.5            552.9         |
 |NATURAL DEATHS (C)      |       (32.0)           (18.5)           (25.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       672.6            694.6            592.7         |
 |(STANDARD ERROR)        |       (16.2)           (10.0)           (22.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE 46                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      537   610   629   629   630   639   642   651   659   661                 |
 |      666   671   686   691   701   731                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.1 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      49    52    128   279   341   524   538   576   577   585                 |
 |      603   607   618   618   625   628   638   653   677   687                 |
 |      687   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.2 G/KG 46                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 1    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      319   428   483   543   555   582   602   618   637   640                 |
 |      663   664   665   713   713   714   718   721   722   722                 |
 |      725                                                                       |
 |  CENSORED DEATHS                                                               |
 |      173                                                                       |
 |                                                                                |
 ==================================================================================

                                     BROMOFORM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE 46 |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  80.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.1 G/KG 46|    96.0  94.0  94.0  90.0  90.0  90.0  86.0  78.0  64.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.2 G/KG 46|   100.0 100.0 100.0  98.0  98.0  93.9  91.8  85.7  73.5  57.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE 46       0.1 G/KG 46      0.2 G/KG 46   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%            56.0%            57.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.329          P=0.150          P=0.358       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       652.1            518.7            626.0         |
 |NATURAL DEATHS (C)      |       (11.0)           (44.3)           (24.0)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       708.5            639.8            678.0         |
 |(STANDARD ERROR)        |       ( 6.5)           (24.6)           (16.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             BROMOFORM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE 46       = 1
                                                        0.1 G/KG 46      = 2
                                                        0.2 G/KG 46      = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                               1   3                 2
      |                                 1   33                2    1                         2
      |                                      3  3   3              1        1       1        2         22
      |                                             3  3                            1 1                 2 2
   90 +                                                33                             1  1
      |                                                                                  1 1              22
      |                                                 3       33                         1       11      222
      |                                                          3     3                            1    1   22
P  80 +                                                                3               3
E     |                                                                                3    3            11   2  2
R     |                                                                                     33        3   1 1  1
C     |                                                                                               33       1 2 1
E  70 +                                                                                                            121
N     |                                                                                                33           212     1
T     |                                                                                                 33  3         2 2
      |                                                                                                     33          22
S  60 +                                                                                                                  2  2
U     |
R     |
V     |
I  50 +
V     |                                                                                                      33
A     |                                                                                                       3  3
L     |
   40 +                                                                                                          33
      |
      |
      |                                                                                                           3  3
   30 +                                                                                                              3  3
      |                                                                                                                 33
      |                                                                                                                  33
      |                                                                                                                   3 3
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                             BROMOFORM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE 46       = 1
                                                        0.1 G/KG 46      = 2
                                                        0.2 G/KG 46      = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1       2                                          3                                 1
      |
      |         22                                         3                3                1           1
      |          2           2                                              3       3                    1 1
   95 +
      |                      2                      2                               3         3
      |                                             2         2
      |                                                                                       3 3
   90 +                                                       2                            2    3   3      1 1
      |
P     |                                                                                    2 2      3  3
E     |                                                                                      2     2   3  3  11
R  85 +
C     |                                                                                                   3 3 1  1
E     |                                                                                            22
N     |                                                                                                     33
T  80 +                                                                                             2   2    3   11
      |
S     |
U     |                                                                                                 2 2       1 1
R  75 +
V     |                                                                                                          3  11  3
I     |                                                                                                   22         1 1
V     |
A  70 +                                                                                                                1    1
L     |
      |                                                                                                    2 2          33  1
      |                                                                                                      2 2
   65 +
      |                                                                                                        2   2     33
      |                                                                                                            2 2
      |
   60 +
      |
      |                                                                                                              2    2 3
      |                                                                                                                   2 2
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.