National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1839

TDMS Study 05057-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            HC YELLOW 4


NTP Experiment-Test: 05057-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 06:16:55




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            2            2                                                  
    Moribund                                           3           10            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           38           43                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (3)          (48)                                                
      Inflammation, Chronic                           10 (22%)                   4 (8%)                                             
   Liver                                              (50)         (18)         (50)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Clear Cell Focus                                 2 (4%)                                                                       
      Fatty Change                                     2 (4%)                                                                       
      Inflammation, Chronic Active                    17 (34%)                  23 (46%)                                            
      Necrosis                                         4 (8%)       1 (6%)      13 (26%)                                            
   Mesentery                                          (2)          (1)          (1)                                                 
      Fibrosis                                         1 (50%)                                                                      
      Inflammation, Chronic Active                     1 (50%)                                                                      
      Necrosis                                         1 (50%)                                                                      
   Pancreas                                           (48)         (3)          (49)                                                
      Inflammation, Chronic                           25 (52%)                  22 (45%)                                            
   Salivary Glands                                    (50)         (2)          (50)                                                
      Inflammation, Chronic                            4 (8%)                                                                       
      Inflammation, Chronic Active                    33 (66%)      1 (50%)     32 (64%)                                            
   Stomach, Forestomach                               (49)         (7)          (50)                                                
      Acanthosis                                       1 (2%)                    3 (6%)                                             
      Hyperkeratosis                                   1 (2%)                    2 (4%)                                             
      Hyperplasia, Basal Cell                                                    2 (4%)                                             
      Hyperplasia, Pseudoepitheliomatous                                         1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       1 (14%)      4 (8%)                                             
      Ulcer                                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (3)          (50)                                                
      Hyperplasia                                      3 (6%)                                                                       
   Adrenal Gland, Medulla                             (49)         (3)          (47)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (3)          (49)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (42)                      (45)                                                
      Pars Distalis, Hyperplasia                       9 (21%)                   8 (18%)                                            
   Thyroid Gland                                      (48)         (49)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Chronic                            1 (2%)       6 (12%)      6 (12%)                                            
      Inflammation, Chronic Active                                               2 (4%)                                             
      C-Cell, Hyperplasia                                                        1 (2%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       1 (2%)                                             
      Follicle, Pigmentation                                       48 (98%)     50 (100%)                                           
      Follicular Cell, Hyperplasia                                  3 (6%)      13 (26%)                                            
      Follicular Cell, Pigmentation                                49 (100%)    50 (100%)                                           
      Interstitium, Pigmentation                                   46 (94%)     50 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (47)         (50)                                                
      Angiectasis                                                   2 (4%)       4 (8%)                                             
      Cyst                                            14 (28%)     17 (36%)     23 (46%)                                            
      Cyst, Multiple                                   4 (8%)       4 (9%)       1 (2%)                                             
      Hemorrhage                                                    9 (19%)     11 (22%)                                            
      Inflammation, Chronic                           16 (32%)      4 (9%)       2 (4%)                                             
      Mineralization                                                1 (2%)       2 (4%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Uterus                                             (50)         (24)         (50)                                                
      Endometriosis                                    1 (2%)                                                                       
      Endometrium, Hydrometra                                                   10 (20%)                                            
      Endometrium, Hyperplasia                        41 (82%)     12 (50%)     36 (72%)                                            
      Endometrium, Metaplasia, Squamous                                          1 (2%)                                             
      Endometrium, Thrombosis                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (3)          (50)                                                
      Myelofibrosis                                   36 (72%)                  42 (84%)                                            
   Lymph Node                                         (49)         (15)         (49)                                                
      Renal, Hyperplasia, Lymphoid                                  1 (7%)                                                          
   Lymph Node, Mesenteric                             (45)         (10)         (44)                                                
      Infiltration Cellular, Histiocyte               26 (58%)      2 (20%)     23 (52%)                                            
   Spleen                                             (49)         (17)         (50)                                                
      Hematopoietic Cell Proliferation                 6 (12%)      3 (18%)      2 (4%)                                             
      Hyperplasia, Lymphoid                           11 (22%)      4 (24%)      3 (6%)                                             
      Pigmentation                                                               1 (2%)                                             
   Thymus                                             (43)         (6)          (41)                                                
      Cyst                                             4 (9%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (4)          (50)                                                
      Joint, Tarsal, Hyperostosis                                   1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (50)                                                
      Gliosis                                                       1 (20%)                                                         
      Thalamus, Mineralization                        34 (68%)      2 (40%)     19 (38%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (8)          (50)                                                
      Hemorrhage                                       3 (6%)                    5 (10%)                                            
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)                                             
   Nose                                               (47)         (3)          (46)                                                
      Inflammation, Acute                              9 (19%)      1 (33%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (4)          (50)                                                
      Inflammation, Chronic                           45 (90%)      3 (75%)     48 (96%)                                            
      Metaplasia, Osseous                                                        1 (2%)                                             
   Urinary Bladder                                    (48)         (4)          (49)                                                
      Inflammation, Chronic                           43 (90%)      2 (50%)     39 (80%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Dead                                              14           10            5                                                  
    Moribund                                           8           10            9                                                  
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           29           35                                                  
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (9)          (46)                                                
      Inflammation, Chronic                            3 (8%)                    4 (9%)                                             
   Intestine Small, Ileum                             (41)         (14)         (45)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (49)         (22)         (48)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Clear Cell Focus                                 1 (2%)                                                                       
      Eosinophilic Focus                                                         1 (2%)                                             
      Infarct                                                       1 (5%)                                                          
      Necrosis                                         9 (18%)      4 (18%)      2 (4%)                                             
      Thrombosis                                                    1 (5%)                                                          
   Pancreas                                           (45)         (16)         (49)                                                
      Inflammation, Chronic                           16 (36%)      1 (6%)      11 (22%)                                            
      Vacuolization Cytoplasmic                       12 (27%)      2 (13%)      8 (16%)                                            
      Duct, Dilatation                                                           1 (2%)                                             
   Salivary Glands                                    (50)         (17)         (49)                                                
      Inflammation, Chronic Active                    33 (66%)      7 (41%)     21 (43%)                                            
   Stomach, Forestomach                               (46)         (19)         (48)                                                
      Acanthosis                                       1 (2%)                                                                       
      Diverticulum                                     1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
   Stomach, Glandular                                 (46)         (16)         (47)                                                
      Hyperplasia                                                   1 (6%)                                                          
      Inflammation, Chronic                            9 (20%)      1 (6%)       8 (17%)                                            
      Mineralization                                   2 (4%)       1 (6%)       4 (9%)                                             
   Tooth                                              (9)          (1)          (6)                                                 
      Dysplasia                                        9 (100%)     1 (100%)     5 (83%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (17)         (49)                                                
      Abscess                                          1 (2%)                                                                       
      Inflammation, Chronic                            8 (16%)                   7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (17)         (48)                                                
      Hyperplasia                                      7 (14%)      1 (6%)       7 (15%)                                            
   Adrenal Gland, Medulla                             (50)         (16)         (47)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (45)         (15)         (49)                                                
      Hyperplasia                                      8 (18%)                                                                      
   Pituitary Gland                                    (38)         (13)         (40)                                                
      Pars Distalis, Cyst                              1 (3%)       1 (8%)                                                          
      Pars Distalis, Hyperplasia                      10 (26%)      1 (8%)       6 (15%)                                            
   Thyroid Gland                                      (47)         (48)         (49)                                                
      Inflammation, Chronic                                         7 (15%)     29 (59%)                                            
      Follicle, Cyst                                                             2 (4%)                                             
      Follicle, Inflammation, Acute                                 1 (2%)                                                          
      Follicle, Pigmentation                                       44 (92%)     48 (98%)                                            
      Follicular Cell, Hyperplasia                                 27 (56%)     41 (84%)                                            
      Follicular Cell, Pigmentation                                44 (92%)     49 (100%)                                           
      Interstitium, Pigmentation                                   42 (88%)     49 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (47)         (49)                                                
      Granuloma Sperm                                  1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                    16 (32%)     13 (28%)     13 (27%)                                            
   Penis                                              (5)          (8)          (4)                                                 
      Inflammation, Chronic Active                     3 (60%)      4 (50%)      2 (50%)                                            
   Preputial Gland                                    (9)          (11)         (6)                                                 
      Abscess                                          3 (33%)      3 (27%)      1 (17%)                                            
      Inflammation, Chronic Active                     5 (56%)      8 (73%)      4 (67%)                                            
      Duct, Dilatation                                 1 (11%)                                                                      
   Prostate                                           (47)         (15)         (45)                                                
      Inflammation, Chronic Active                    34 (72%)      7 (47%)     20 (44%)                                            
   Seminal Vesicle                                    (49)         (21)         (49)                                                
      Inflammation, Chronic Active                    11 (22%)      4 (19%)     14 (29%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Testes                                             (50)         (17)         (49)                                                
      Spermatogenic Arrest                                          1 (6%)       1 (2%)                                             
      Germinal Epithelium, Giant Cell                               1 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (49)         (21)         (48)                                                
      Depletion Lymphoid                              11 (22%)      9 (43%)      5 (10%)                                            
      Hematopoietic Cell Proliferation                 6 (12%)      6 (29%)      5 (10%)                                            
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Thymus                                             (28)         (9)          (29)                                                
      Cyst                                             8 (29%)      1 (11%)      4 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (32)         (48)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic Active                     8 (16%)      4 (13%)      5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (39)         (48)                                                
      Joint, Tarsal, Hyperostosis                     17 (34%)     24 (62%)     17 (35%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (18)         (49)                                                
      Thalamus, Mineralization                        29 (58%)      6 (33%)     25 (51%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (49)                                                
      Crystals                                                      1 (3%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    3 (6%)                                             
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
   Nose                                               (49)         (14)         (47)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute                              6 (12%)                   3 (6%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05057-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:16:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (22)         (49)                                                
      Abscess                                          2 (4%)                                                                       
      Cyst                                             1 (2%)                    3 (6%)                                             
      Hydronephrosis                                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                    38 (78%)     15 (68%)     44 (90%)                                            
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (5%)                                                          
      Papilla, Mineralization                                                    1 (2%)                                             
      Renal Tubule, Mineralization                     7 (14%)      2 (9%)       4 (8%)                                             
   Urethra                                            (1)          (1)                                                              
      Inflammation, Chronic Active                     1 (100%)     1 (100%)                                                        
   Urinary Bladder                                    (44)         (17)         (50)                                                
      Calculus Micro Observation Only                               1 (6%)       1 (2%)                                             
      Hemorrhage                                                    2 (12%)                                                         
      Inflammation, Chronic Active                    28 (64%)      5 (29%)     25 (50%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
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