National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1843

TDMS Study 05057-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            HC YELLOW 4


NTP Experiment-Test: 05057-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 06:20:57




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            2            2                                                  
    Moribund                                           3           10            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           38           43                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (3)          (48)                                                
   Intestine Large, Cecum                             (47)         (3)          (49)                                                
   Intestine Large, Rectum                            (49)         (3)          (47)                                                
   Intestine Small, Duodenum                          (46)         (9)          (50)                                                
   Intestine Small, Ileum                             (45)         (11)         (48)                                                
   Intestine Small, Jejunum                           (47)         (8)          (49)                                                
   Liver                                              (50)         (18)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           4 (8%)       6 (33%)      4 (8%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (11%)                                                         
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
   Mesentery                                          (2)          (1)          (1)                                                 
   Pancreas                                           (48)         (3)          (49)                                                
   Salivary Glands                                    (50)         (2)          (50)                                                
   Stomach, Forestomach                               (49)         (7)          (50)                                                
      Squamous Cell Papilloma                          3 (6%)       2 (29%)      1 (2%)                                             
   Stomach, Glandular                                 (49)         (6)          (50)                                                
   Tooth                                              (2)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (4)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (3)          (50)                                                
   Pituitary Gland                                    (42)                      (45)                                                
      Pars Distalis, Adenoma                           5 (12%)                   1 (2%)                                             
   Thyroid Gland                                      (48)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (47)         (50)                                                
      Cystadenoma                                      2 (4%)                    3 (6%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                    1 (2%)                                             
      Teratoma                                                                   1 (2%)                                             
   Uterus                                             (50)         (24)         (50)                                                
      Polyp Stromal                                    2 (4%)       1 (4%)                                                          
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (3)          (50)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Lymph Node                                         (49)         (15)         (49)                                                
   Lymph Node, Mandibular                             (45)         (5)          (45)                                                
      Adenocarcinoma, Metastatic, Harderian Gland      1 (2%)                                                                       
   Lymph Node, Mesenteric                             (45)         (10)         (44)                                                
   Spleen                                             (49)         (17)         (50)                                                
      Hemangiosarcoma, Metastatic, Skeletal Muscle                  1 (6%)                                                          
   Thymus                                             (43)         (6)          (41)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (2)          (37)                                                
      Adenocarcinoma                                   1 (3%)       1 (50%)      1 (3%)                                             
   Skin                                               (50)         (40)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (2)                                                 
      Hemangiosarcoma                                               1 (100%)                                                        
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (50%)                                            
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (8)          (50)                                                
      Adenocarcinoma, Metastatic, Harderian Gland      1 (2%)                                                                       
      Adenocarcinoma, Metastatic, Mammary Gland                                  1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (25%)      1 (2%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Trachea                                            (49)         (3)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (2)                                                 
      Adenocarcinoma                                   1 (50%)                                                                      
      Adenoma                                          1 (50%)      1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (4)          (50)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Urinary Bladder                                    (48)         (4)          (49)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   1 (2%)       3 (6%)                                                          
      Lymphoma Malignant Mixed                         6 (12%)      4 (8%)       5 (10%)                                            
      Lymphoma Malignant Undifferentiated Cell         2 (4%)       6 (12%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          24          20                                                   
     Total Primary Neoplasms                           39          30          24                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          13          11                                                   
     Total Benign Neoplasms                            23          14          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          15          11                                                   
     Total Malignant Neoplasms                         16          16          11                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           3                                                   
     Total Metastatic Neoplasm                          2           1           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Dead                                              14           10            5                                                  
    Moribund                                           8           10            9                                                  
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           29           35                                                  
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (9)          (46)                                                
   Intestine Large, Colon                             (47)         (14)         (47)                                                
   Intestine Large, Rectum                            (40)         (14)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (41)         (14)         (45)                                                
   Intestine Small, Jejunum                           (42)         (14)         (45)                                                
   Liver                                              (49)         (22)         (48)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         4 (8%)       5 (23%)      8 (17%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)       2 (9%)       1 (2%)                                             
      Hepatocellular Adenoma                           8 (16%)      7 (32%)      4 (8%)                                             
      Lipoma                                           1 (2%)                                                                       
   Mesentery                                          (1)                       (1)                                                 
      Sarcoma                                                                    1 (100%)                                           
   Pancreas                                           (45)         (16)         (49)                                                
   Salivary Glands                                    (50)         (17)         (49)                                                
   Stomach, Forestomach                               (46)         (19)         (48)                                                
      Squamous Cell Papilloma                          3 (7%)       2 (11%)      1 (2%)                                             
   Stomach, Glandular                                 (46)         (16)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (17)         (49)                                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (17)         (48)                                                
      Adenoma                                          1 (2%)                                                                       
      Adenoma, Multiple                                1 (2%)                                                                       
   Thyroid Gland                                      (47)         (48)         (49)                                                
      Follicular Cell, Adenoma                         1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (47)         (49)                                                
   Preputial Gland                                    (9)          (11)         (6)                                                 
      Fibrosarcoma                                     1 (11%)                                                                      
   Prostate                                           (47)         (15)         (45)                                                
   Testes                                             (50)         (17)         (49)                                                
      Sertoli Cell Tumor Benign                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (16)         (47)                                                
   Lymph Node                                         (46)         (28)         (47)                                                
      Mediastinal, Pancreatic, Sarcoma, Metastatic,                                                                                 
           Skeletal Muscle                                          1 (4%)                                                          
   Lymph Node, Mandibular                             (42)         (9)          (40)                                                
   Lymph Node, Mesenteric                             (38)         (24)         (45)                                                
   Spleen                                             (49)         (21)         (48)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (28)         (9)          (29)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (32)         (48)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (3%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                5 (10%)      2 (6%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (18)         (49)                                                
      Meningioma Benign                                             1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      8 (28%)      5 (10%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (3%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (3%)       2 (4%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                       (3)                                                 
      Adenoma                                          1 (50%)                   3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (22)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (5%)                                                          
   Urinary Bladder                                    (44)         (17)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(50)                                                
      Lymphoma Malignant Mixed                         1 (2%)                                                                       
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05057-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 06:20:57  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATE     0.5%         1.O%                                                   
                                                   D 61UM       61LM         61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            28          23          23                                                   
     Total Primary Neoplasms                           44          31          34                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          17          13                                                   
     Total Benign Neoplasms                            25          19          16                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          12          16                                                   
     Total Malignant Neoplasms                         19          12          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2                                                   
     Total Metastatic Neoplasm                                      5           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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