National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1847

TDMS Study 05057-02 Pathology Tables

NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97
Route: DOSED FEED                                                                                                 Time: 16:50:08




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                |                      1                       1     1              1      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  M  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  M  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change                         |                                                                          |             
      Inflammation, Chronic Active         | 1     2  1           1        1  1  1              2        1  1         |             
      Necrosis                             |          1           1                                         1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    M                                   M                                 |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
      Inflammation, Chronic                | 1        1        1  2        1     1              2        1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2  1  1  1     2  1  2  1  1     1                 1        2  2  2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                   1                                         1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +     M  +  +  I  M  +  M  +  +     +  +  M        M  +  M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  M  +     +  M  +  +  +  +  M  +  +     +  +  M        +  M  +      |             
      Pars Distalis, Hyperplasia           | 2              2                    2           2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                |                            1                                             |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Cyst                                 | 2                 3  3           3                          3  4         |             
      Cyst, Multiple                       |          3                                         3              3      |             
      Inflammation, Chronic                | 2     2        2  2  2  1     1                             2     1      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                        A                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Endometriosis                        |                                                                          |             
      Endometrium, Hyperplasia             | 2  1  3  2     2  2  3  2     2  3  2        1  3  3        4  3  4      |             
      Endometrium, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Myelofibrosis                        |       2  3     2  1  1  1     2  2  3        2     2        2  2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  M  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +     +  +  +  +  +  +  +  +  M     +  +  +        M  +  +      |             
      Infiltration Cellular, Histiocyte    | 1     1  1     1  1  1  1     1  1           1     1           1  1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
      Hematopoietic Cell Proliferation     |                                              3                           |             
      Hyperplasia, Lymphoid                |                                              3     3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  +  +  +  +  +  +  M     +  +  +        +  +  +      |             
      Cyst                                 |    1     1              1                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M     M  +  +  +  +  +  +  M  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thalamus, Mineralization             | 1     1  1        1  1  1     1  1  1        1  1           1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  M  +  +     +  +  M        +  +  +      |             
      Inflammation, Acute                  |                1           1                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +        +  +  +      |             
      Inflammation, Chronic                | 2  1  2  1     1  1  1  1  2  1  1     2     1     1        1  1  2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  A     +  +  +        +  +  +      |             
      Inflammation, Chronic                | 1  1  2  1     1  1  1     1  2  2           1  2  2        2  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  M     +  +  +  +     +  +           M  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
      Inflammation, Chronic                |       1  1              1     1  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +  +     +  A           M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +     +  +  +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Clear Cell Focus                     | 1     1                                                                  |             
      Fatty Change                         |                               1                                          |             
      Inflammation, Chronic Active         |       1        1                    1                                    |             
      Necrosis                             |                1                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                               M   |             
      Fibrosis                             |                      2                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic                | 1     1  1        1           1  1     1     1                    1  1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 1     1  1     1  1  2        3  2  1  1     1                 2  2  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Acanthosis                           |                               1                                          |             
      Hyperkeratosis                       |                               1                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hyperplasia                          |    1     1                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     M  +  +  M     +  M  M  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  M  +     +  +           +  +  +  +   |             
      Pars Distalis, Hyperplasia           |       2                                         1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  M     +  +  +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Cyst                                 | 4              4     2                                                   |             
      Cyst, Multiple                       |          2                                                               |             
      Inflammation, Chronic                |       1  1     1                 2     1                       2         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Endometriosis                        |                                                             3            |             
      Endometrium, Hyperplasia             | 4  3  2  4     2  2  3        2     2        3                 2  2      |             
      Endometrium, Thrombosis              |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Myelofibrosis                        | 2  1  2  2     1     2        1     1  1     3                 2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | I  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  +     +  +  +  +     M  +  +  M     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +     +  +  +  +     +  +  +  +     +  +           +  M  +  +   |             
      Infiltration Cellular, Histiocyte    |    1  1           1                          1                    1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                         3     2                                          |             
      Hyperplasia, Lymphoid                | 4                             2  3           2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  +  M     +  +  +  +     +  M           +  +  +  M   |             
      Cyst                                 |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M     +  +  M  M     +  +  M  +     M  +           M  M  M  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|             
                                           | 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thalamus, Mineralization             | 1     1  1     1  1  1  1     1     1  1     1              1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Hemorrhage                           |          2                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  M  +  +   |             
      Inflammation, Acute                  |    1                    1                       1                 1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  M     +  +  +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic                | 1     1  2     1  2  1  2     2  2  1  1     1  1              1  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic                |       1  2     1  2  1  1     2  1  2  2        1           1  1  1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  46        |
      Inflammation, Chronic                | 1                                                                        |     10  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Fatty Change                         |                                        1                                 |      2  1.0|
      Inflammation, Chronic Active         | 2  2  1                                      1                           |     17  1.2|
      Necrosis                             |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  48        |
      Inflammation, Chronic                |    1  1           1  1        1        1        1                        |     25  1.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Inflammation, Chronic                |                               1     1  1        1                        |      4  1.0|
      Inflammation, Chronic Active         | 1     1        1  1  1                                                   |     33  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Acanthosis                           |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                      1                                                   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                               1                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +        +  +  +  +     +  +                        |  42        |
      Pars Distalis, Hyperplasia           | 1     2                                      2                           |      9  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  48        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Cyst                                 |    2  2           1              1           4                           |     14  2.7|
      Cyst, Multiple                       |                                                                          |      4  2.8|
      Inflammation, Chronic                |                      2                                                   |     16  1.6|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Endometriosis                        |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             | 2  3  3        3  2  3        3  2  2  1     3  2                        |     41  2.5|
      Endometrium, Thrombosis              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Myelofibrosis                        | 1  2  2        2  2  1           3  1  1     1                           |     36  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M        +  +  +  +     +  +  +  +     +  +                        |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  45        |
      Infiltration Cellular, Histiocyte    |       1        1  1  1        1  1     1     1                           |     26  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
      Hematopoietic Cell Proliferation     |                   2  2                 2                                 |      6  2.3|
      Hyperplasia, Lymphoid                | 2  1                          1              1  2                        |     11  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M        +  +  +  +     +  +  +  +     +  +                        |  43        |
      Cyst                                 |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4|              |            |
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|              |            |
                                           | 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +        M  +  +  +     M  M  +  +     +  M                        |  31        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Thalamus, Mineralization             |       1           1  1              1  1     1                           |     34  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Hemorrhage                           | 1                                      1                                 |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  47        |
      Inflammation, Acute                  |                      1              1        1                           |      9  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +     +  +  +  +     +  +                        |  50        |
      Inflammation, Chronic                | 1  1  1        2  1  1        2  1  1  1     1  1                        |     45  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  A     +  +  +  +     +  +                        |  48        |
      Inflammation, Chronic                | 1  1  2        1  2  1        2  2  1  2     2  1                        |     43  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +                                +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +                                +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   |             +        +  +           +              +        +  +  +      |             
      Necrosis                             |                                     2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                       +  +        +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                       +  +        +                        |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                          +        +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                                      +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             M                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             M                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +     +  M  +        +  +  +      |             
      Inflammation, Chronic                | 1           1                                                            |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Pigmentation               | 1  1  1  1  1  1  1  1  1     1  1  1  1     2     1        1  1  1      |             
      Follicular Cell, Hyperplasia         |                1                                                         |             
      Follicular Cell, Pigmentation        | 1  1  1  2  2  2  1  1  1     1  1  1  1     2     1        4  1  1      |             
      Interstitium, Pigmentation           | 1  1  1  1  1  1  1  1  1     1  1  1  1     1     1        1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  M     +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    4  2  2  2        3  1           1           1                        |             
      Cyst, Multiple                       |                2                                                         |             
      Hemorrhage                           |       2              2  2                                                |             
      Inflammation, Chronic                |             2                                                            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +                    +     +        +  +        +     +      |             
      Endometrium, Hyperplasia             |    3  3                          3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +  M     +        +  +        +     +                     |             
      Renal, Hyperplasia, Lymphoid         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                    M                 +                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +     M           +        +           +                           |             
      Infiltration Cellular, Histiocyte    | 1     1                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +     +        +  +  +     +                           |             
      Hematopoietic Cell Proliferation     |             3                          2                                 |             
      Hyperplasia, Lymphoid                |       2        2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  M           +                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +     +        +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +                                                            |             
      Joint, Tarsal, Hyperostosis          |          3                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                       +              +                     |             
      Gliosis                              |                                                    2                     |             
      Thalamus, Mineralization             |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +                       +           +                        |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                                                            |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|             
                                           | 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +                                                |             
      Inflammation, Chronic                |             2           1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                                      +                     |             
      Inflammation, Chronic                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +  +                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +              +  +                          +                       +   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |                                              1        1           2      |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Pigmentation               | 1  1           1  1  1        1  1           1  1  1  1     1  1  1  1   |             
      Follicular Cell, Hyperplasia         |                               1                                          |             
      Follicular Cell, Pigmentation        | 1  1           1  1  2        1  1           1  1  1  1     1  1  1  1   |             
      Interstitium, Pigmentation           | 1  1           1  1  1        1  1           1  1  1  1     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +           +  +  +        +  +           +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                       1                  |             
      Cyst                                 |                2                 2           4        1        1         |             
      Cyst, Multiple                       |                      2                                                   |             
      Hemorrhage                           |                2                 2                    1                  |             
      Inflammation, Chronic                |                                                 1                 1      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +              +     +                          +     +                  |             
      Endometrium, Hyperplasia             | 3              3     2                          2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +                                                   |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 M                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +              +  +                                                   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +              +  +                             +                     |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                                         +                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   +                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           M  +           +  +           +  +  +        +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Gliosis                              |                                                                          |             
      Thalamus, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                           M              +               |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                 +        +           +  +               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                 +        +           +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +                 +        +           +  +               |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                 +        M           +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +                       +           +  +               |  18        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                           M              +               |   2        |
      Inflammation, Chronic Active         |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +                       +              +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +                       +              +               |   7        |
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +                       +              +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                           +              +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                           +              +               |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                           M              M               |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +  +  +  +     +  +  +     +  +  +  +  +  +               |  49        |
      Inflammation, Chronic                |                   1                                                      |      6  1.2|
      Follicle, Cyst                       |                                  1                                       |      1  1.0|
      Follicle, Pigmentation               | 1     1  1     1  1  1  1     1  1  1        1  1  1  1  1               |     48  1.0|
      Follicular Cell, Hyperplasia         |                   2                                                      |      3  1.3|
      Follicular Cell, Pigmentation        | 1     1  1     1  1  1  1     1  1  2     1  1  1  1  2  1               |     49  1.2|
      Interstitium, Pigmentation           | 1     1        1  1  1  1     1  1  1        1     1  1  1               |     46  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +     +  +  +  +     +  +  +     +  M  +  +  +  +               |  47        |
      Angiectasis                          |          1                                                               |      2  1.0|
      Cyst                                 |       2  2              3           1                                    |     17  2.0|
      Cyst, Multiple                       |                      2                          2                        |      4  2.0|
      Hemorrhage                           |                      2              1           1                        |      9  1.7|
      Inflammation, Chronic                | 1                                                                        |      4  1.3|
      Mineralization                       |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +                 +     +           +  +  +     +  +               |  24        |
      Endometrium, Hyperplasia             | 3     4                       2              2  2                        |     12  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                           +              +               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +           +  +               |  15        |
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                           +           +  M               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                           M           +  +               |  10        |
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +                       M           +  +               |  17        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hyperplasia, Lymphoid                |                   1                                                      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                     M     M              +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                           M              M               |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +     +  +  +     M  +     +  +  +               |  40        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                           +              +               |   4        |
      Joint, Tarsal, Hyperostosis          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                           +              +               |   5        |
      Gliosis                              |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                                                          1               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                         +                 +  +     +     +               |   8        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                           +              +               |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1|              |            |
                                           | 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                           +              +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                           +              +               |   4        |
      Inflammation, Chronic                |                                                          1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                           +              +               |   4        |
      Inflammation, Chronic                |                                           1                              |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  M           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Inflammation, Chronic Active         |    1  1        1              1        1        1              1  1      |             
      Necrosis                             |    1                          1     2                             1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                | 2     1                          2           1  1           1  1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         | 2     1        1  1                    1        1        1  2  1  1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Acanthosis                           | 2                                                           2            |             
      Hyperkeratosis                       |                                                             2            |             
      Hyperplasia, Basal Cell              | 1                                                           2            |             
      Hyperplasia, Pseudoepitheliomatous   |                                                                      1   |             
      Inflammation, Chronic Active         | 2                                                           2            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +           +  +  +  +     +  M  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M        +  +           M  +  +  M     +  M  +  +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +           M  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Hyperplasia           |                                     1        1  2                 1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                  1                                       |             
      Inflammation, Chronic                |                1                             1                           |             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                 2                        |             
      Follicle, Pigmentation               | 1  2  2        2  1           2  2  1  1     1  1  2  2  1  2  2  1  2   |             
      Follicular Cell, Hyperplasia         |                1  1                 2                          1  1      |             
      Follicular Cell, Pigmentation        | 1  2  2        2  1           2  2  1  1     1  1  2  2  1  2  2  1  2   |             
      Interstitium, Pigmentation           | 1  1  1        1  1           1  1  1  1     1  1  1  1  1  1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                       2  1               |             
      Cyst                                 |    2  4        3  2           2                                   3  2   |             
      Cyst, Multiple                       |                                  2                                       |             
      Hemorrhage                           |       3        2              2  2           1                           |             
      Inflammation, Chronic                | 1                                               1                        |             
      Mineralization                       |                1                       2                                 |             
      Thrombosis                           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Endometrium, Hydrometra              |       3                                3                       1         |             
      Endometrium, Hyperplasia             | 2  2           3  3              1  1  1     1  2  2  2  3  2     2      |             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Myelofibrosis                        | 1  2  2        2  2           1  1  1  2     2  1  1  1  1  1  1  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +        M  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Histiocyte    |    1  1           1                          1  1  1  1  1  1  1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +        +  +           +  +  +  M     M  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M        +  +           +  +  M  +     +  M  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
                                           | 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Thalamus, Mineralization             |                   1                             1  1  1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  M  M  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                | 2  1  1        1  1           1  1  1  1     1  1  1  1  1  2     1      |             
      Metaplasia, Osseous                  |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +           +  +  +  +     +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                | 1     1        1              1  1  1  1     1  1  1  1  1  1  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Inflammation, Chronic                |                      1  1     1                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  M  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +     +  +           +  +           +  +  M      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Basophilic Focus                     |                                                 2                        |             
      Inflammation, Chronic Active         | 1     1        1     1  1                    1                 1         |             
      Necrosis                             | 1                       1        1                             1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Inflammation, Chronic                | 1  1  1        1  1     1                    1  1           1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Inflammation, Chronic Active         |    1           1  1     1     2              2  1           1  1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +        M  +  +  +     +  +           +  +           +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  I  +     I  M           +  I           +  M  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  I  +        +  +  +  +     +  +           M  M           +  +  +      |             
      Pars Distalis, Hyperplasia           |       2           1                                         2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Pigmentation               | 1  1  1        1  2  1  2     1  1           1  1           2  2  2      |             
      Follicular Cell, Hyperplasia         |       1                 2                                                |             
      Follicular Cell, Pigmentation        | 1  1  1        1  2  1  2     1  1           1  1           2  2  2      |             
      Interstitium, Pigmentation           | 1  1  1        1  1  1  1     1  1           1  1           1  2  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 1     2              2                                                   |             
      Cyst, Multiple                       |                                                                          |             
      Hemorrhage                           | 1                    2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Endometrium, Hydrometra              |                                                 3                        |             
      Endometrium, Hyperplasia             | 2  3  3           2     2     2  3           2              3  2  3      |             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Myelofibrosis                        | 2  2  1        2  1  2  2     2              2  2           3  2  1      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +        M  M  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  I     +  +           M  +           M  +  +      |             
      Infiltration Cellular, Histiocyte    | 1              1     1                                         1  1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                  2      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +     M  +           +  +           +  +  M      |             
      Cyst                                 |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +        +  +  M  M     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|             
                                           | 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Thalamus, Mineralization             | 1                       1                       1           1  1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Hemorrhage                           |                               2                 1                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +     M  +           +  +           M  +  +      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Inflammation, Chronic                | 1  1  1        1  1  1  2     1  1           1  1           1  1  1      |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +     +  +           +  +           +  +  +      |             
      Inflammation, Chronic                |       1        1  2  1  1     1  1           1  2           1  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  48        |
      Inflammation, Chronic                |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1     1  1  1  1  1                 1        1                           |     23  1.0|
      Necrosis                             |          1        1                          1     2                     |     13  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |    1                 2           1  1        1  1                        |     22  1.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Inflammation, Chronic Active         |    1     1  1  1  1        1  1  1  1        1  1  1  1                  |     32  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Acanthosis                           |                                              2                           |      3  2.0|
      Hyperkeratosis                       |                                              1                           |      2  1.5|
      Hyperplasia, Basal Cell              |                                                                          |      2  1.5|
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                 1     2                  |      4  1.8|
      Ulcer                                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  47        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  I  +  M  +  +  +  M  M  +  M  +     +  M  +  M                  |  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  45        |
      Pars Distalis, Hyperplasia           |                                     2                                    |      8  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Inflammation, Acute                  |                                        1                                 |      2  1.0|
      Inflammation, Chronic                | 1              1                 1                                       |      6  1.0|
      Inflammation, Chronic Active         |    1                                            1                        |      2  1.0|
      C-Cell, Hyperplasia                  |             1                                                            |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Pigmentation               | 1  2  2  2  1  2  2  2  2  2  1  2  2  2     2  2  2  1                  |     50  1.6|
      Follicular Cell, Hyperplasia         |       1        2     1              2        1     1                     |     13  1.3|
      Follicular Cell, Pigmentation        | 1  2  2  2  1  2  2  2  2  2  1  2  2  2     2  2  2  2                  |     50  1.6|
      Interstitium, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1                  |     50  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Angiectasis                          |                                     2              2                     |      4  1.8|
      Cyst                                 |    3  2  1  2  4  2     4  3     4  1  3        2  3                     |     23  2.5|
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Hemorrhage                           |       2           2                    3           3                     |     11  2.1|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      2  1.5|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Endometrium, Hydrometra              |    3        3  3  2  2              3                                    |     10  2.6|
      Endometrium, Hyperplasia             | 3  2  2  2     2     1        2     3        2  3  2                     |     36  2.2|
      Endometrium, Metaplasia, Squamous    | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Myelofibrosis                        | 2  2  1  2     1  3  1           2  2        1  1  2                     |     42  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +                  |  44        |
      Infiltration Cellular, Histiocyte    |    1        1  1     1           1  1           1  1                     |     23  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7|              |            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Hematopoietic Cell Proliferation     |                         3                             3                  |      2  3.0|
      Hyperplasia, Lymphoid                |             2                                                            |      3  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  M  +  +  +  +  +     M  +  +  +                  |  41        |
      Cyst                                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  M  +  M  +  +  M     +  +  +  +                  |  37        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Thalamus, Mineralization             |    1                             1     1     1  1  1  1                  |     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Hemorrhage                           | 1           1                                                            |      5  1.2|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  46        |
      Inflammation, Acute                  |                                        1        1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  50        |
      Inflammation, Chronic                | 1  1  1  2  1  1  1  1  1  2  1  1  1  1     2  2  1  1                  |     48  1.1|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |    1     1        1  1  1  1  2  1  1        2  1  1  1                  |     39  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     M     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  M  M     +     M  A  +  +     +  +     M        A   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +     +     +  M  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +     +     M  +  +  +     M  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  M  +  +  +  A     +     +  +  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  A     +     +  +  +  A     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  A     +     A  M  +  +     +  +     +        A   |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  A     +     +  +  +  A     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Clear Cell Focus                     | X                                                                        |             
      Necrosis                             |                                              2     1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        M                             A   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  M     +     +  +  +  +     +  +     +        +   |             
      Inflammation, Chronic                |                1  1                                1                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Inflammation, Chronic Active         | 1  2     1     1  1           1     1  1           1  2     1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        M   |             
      Acanthosis                           |                                                                          |             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        A   |             
      Inflammation, Chronic                |                   1           2                       1                  |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Abscess                              |             1                                                            |             
      Inflammation, Chronic                |                   1     1                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Hyperplasia                          |                   1  2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  M     +     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  I  M  +  +     M     +  M  M  M     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  I  +  +  M  +     +     +  M  M  M     M  +     +        +   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       1        1  1           2                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     M     +  +  M  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic Active         |       1  1           1                             1                     |             
                                            __________________________________________________________________________|             
   Penis                                   |             M           +           +     +                              |             
      Inflammation, Chronic Active         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +              +        +              +                  |             
      Abscess                              |                4              3                       4                  |             
      Inflammation, Chronic Active         |                               4                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Inflammation, Chronic Active         |       1  1  3  1  1  1  2              2  4        1        1        1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Inflammation, Chronic Active         |                   1                       2           1                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        M   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +     M  +  +  +     +  +     +        M   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  I  +  +  +     M     +  A  M  +     +  +     +        M   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Depletion Lymphoid                   |                         3           2  2  1                          2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  A  +  M  M  M     M     +  A  M  M     +  +     +        +   |             
      Cyst                                 |       1                                                     2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M     M     M  M  M  M     +  M     M        M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +     M  +  +  +     +  +     +        +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|             
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Joint, Tarsal, Hyperostosis          |    4     4        4  4        4                    4  4     4            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Thalamus, Mineralization             |    2  1  1     1  1  1        1        1  1  1     1        1        1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |    1                                         2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     M     +  +  +  +     +  +     +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +     +  +  +  +     +  +     +        +   |             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         | 1  1  1  1        1  1        1     1        1     1  1     1        1   |             
      Necrosis                             |                                                                          |             
      Renal Tubule, Mineralization         |             1           1           1  1  2                          1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +     +     +  A  +  +     +  +     +        A   |             
      Inflammation, Chronic Active         | 1  1     1     1  1                       2           1     1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +     +           +     +  A     M  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Clear Cell Focus                     |                                                                          |             
      Necrosis                             |          2  1                                            1        2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic                |          1        1                 1        1  1  1     1     1  1      |             
      Vacuolization Cytoplasmic            |       1  1                    2     1        1  1  1           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic Active         | 1  1  1  2        1           1     1  1     1  1  1  1  1     1  1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Acanthosis                           |       2                                                                  |             
      Diverticulum                         |                                                                   2      |             
      Hyperkeratosis                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic                |                                              1  1     1           1      |             
      Mineralization                       |                                                          1               |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                             +  +                       +         |             
      Dysplasia                            |       3                             3  2                       4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                   1                             2        1               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Hyperplasia                          |          2                                      1     2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M     +           +     +  M     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       1                             1                 2        2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +     M           +     +  M     +  +  +  +  M     M  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +     M           +     +  +     +  +  +  +  +     +  +     M|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          1                                      1     1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic Active         | 1        1        1           1     1        2  1     1                  |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                                   +  +                 +      |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                              1  2                 2      |             
      Duct, Dilatation                     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  M     +           +     +  +     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic Active         | 1     1           2           1     1  1     1  1  1  1  1     1  1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic Active         |             1                                1  1  1                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +           +     +  M     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Depletion Lymphoid                   |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                                                          3              3|             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  M  +  +     +           M     +  I     +  +  +  +  M     +  M     +|             
      Cyst                                 |          1        1                                1           1         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M           M     M  M     M  M  M  M  M     M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Cyst Epithelial Inclusion            |          3                                                               |             
      Inflammation, Chronic Active         |             1                          2                 2              4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|             
                                           | 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Joint, Tarsal, Hyperostosis          |       4                                      4     4  4                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Thalamus, Mineralization             | 1     1  1  1                          1     1  1  1  1  1        1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
      Cyst                                 |    1                                                                     |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +           +     +  +     +  +  +  +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                           +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |             2                                                            |             
      Inflammation, Chronic Active         |    1  1  1        2           1     1        1  1  1  2  2     1  1     1|             
      Necrosis                             |             2                                                            |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +           +     +  A     +  +  +  +  +     +  +     +|             
      Inflammation, Chronic Active         | 2  2  1  1                    1     1        1  1  1  1        1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M     +     +     +  +  +  +  +  +  +                     |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +     +     M     +  +  +  +  +  +  +                     |  39        |
      Inflammation, Chronic                |    1     1                                                               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +     +     +  A  +  +  +  +  +                     |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +     +     +     +  A  +  +  +  +  +                     |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +     +     +  A  +  +  +  +  +                     |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +     +     +     +  A  M  +  +  +  +                     |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  41        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +     +     +     +  A  A  +  +  +  +                     |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Clear Cell Focus                     |                                                                          |      1     |
      Necrosis                             | 1                                         1                              |      9  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +     +     +     +  +  M  +  +  +  +                     |  45        |
      Inflammation, Chronic                | 1     1  1                                   2                           |     16  1.1|
      Vacuolization Cytoplasmic            | 1        1                                      1  1                     |     12  1.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Inflammation, Chronic Active         |    1  1  2     1                 1           1     1                     |     33  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
      Acanthosis                           |                                                                          |      1  2.0|
      Diverticulum                         |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +     +     +  +  A  +  +  +  +                     |  46        |
      Inflammation, Chronic                |                                              1     1                     |      9  1.1|
      Mineralization                       |                                              1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +                                         +  +  +                     |   9        |
      Dysplasia                            | 4  1                                         1  1  4                     |      9  2.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Abscess                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1           1                                1                        |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Hyperplasia                          |    2                                            2                        |      7  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +     +     +  +  M  +  +  +  +                     |  45        |
      Hyperplasia                          | 1        2                                         2                     |      8  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  +  I     +     M     M  +  M  M  +  +  M                     |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +     +     +  +  +  +  +  M  M                     |  38        |
      Pars Distalis, Cyst                  |    2                                                                     |      1  2.0|
      Pars Distalis, Hyperplasia           | 2                    1                                                   |     10  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +     +     +     +  +  +  +  +  +  +                     |  47        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Granuloma Sperm                      |                                                    2                     |      1  2.0|
      Inflammation, Chronic Active         |    1     1     1           1                                             |     16  1.1|
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +     +                                             |   5        |
      Inflammation, Chronic Active         |                      2     3                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   9        |
      Abscess                              |                                                                          |      3  3.7|
      Inflammation, Chronic Active         |                      1                                                   |      5  2.0|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  47        |
      Inflammation, Chronic Active         |    1  1  1     1           4     1        3  1  1                        |     34  1.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Inflammation, Chronic Active         |       1                          2        3  1                           |     11  1.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +     +     +  +  +  M  +  +  +                     |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M     +     +     +  M  +  +  +  +  +                     |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M     +     +     +  M  +  M  +  +  +                     |  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  M     M     +     +  M  M  +  +  +  +                     |  38        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Depletion Lymphoid                   |                      1     3        3  2  2                              |     11  2.1|
      Hematopoietic Cell Proliferation     |    4                                3     3  3                           |      6  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  A  M     M     +     +  M  M  +  +  +  +                     |  28        |
      Cyst                                 |    1                                         1                           |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M     M     M     M  M  M  M  M  M  M                     |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                  1           1  2                        |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Joint, Tarsal, Hyperostosis          |    4     4     4                             4  4                        |     17  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Thalamus, Mineralization             |    1  1  1     1                                   1                     |     29  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Acute                  | 2              3     1                             1                     |      6  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +     +     +  +  M  +  +  +  +                     |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +     +     +  +  +  +  +  +  +                     |  49        |
      Abscess                              |                                     4     2                              |      2  3.0|
      Cyst                                 |                                              1                           |      1  1.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1  1  1  2           1     1     2  4        1  1  1                     |     38  1.2|
      Necrosis                             |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                        1                                 |      7  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   1        |
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1|              |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9|              |            |
                                           | 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61UM                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +     +     +     +  +  A  +  +  +  +                     |  44        |
      Inflammation, Chronic Active         | 1  2     1     1           1        3        1     1                     |     28  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +           +        +     +        +  M                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A  M  +           M        +     +        M  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          M  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A  +  +           A        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +  +  +        +        +     +        +  +           +      |             
      Infarct                              |                3                                                         |             
      Necrosis                             |                   1                                   3                  |             
      Thrombosis                           |                4                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +  +           +        +     +        +  +                  |             
      Inflammation, Chronic                |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +  +           +        +     +        +  +                  |             
      Inflammation, Chronic Active         |                1                                   1  1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +           +        +     +        +  +              +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +           +        +     +        +  +              +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +           +        +     +        +  +                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                    1                     |             
      Mineralization                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +           +        +     +        +  +                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +  +           +        +     +        +  +                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  M  +           M        M     +        M  M                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +           +        M     M        +  +                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                1                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +     +     +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |                                                    1                 1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Inflammation, Acute        |                                                    1                     |             
      Follicle, Pigmentation               | 2  2     1     1  2  2        2     2        2  2  2  1     2  2  2  1   |             
      Follicular Cell, Hyperplasia         | 1  2                 1        2              2              1  1  3      |             
      Follicular Cell, Pigmentation        | 2  2     1     2  2  2        2     2        1  1  2  2     1  1  1  1   |             
      Interstitium, Pigmentation           | 1  1           1  1  1        1     1        1  1  1  1     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +     +  +     +     +     +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         | 2  1     1        1  1                             1           1         |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                      +           +     +      |             
      Inflammation, Chronic Active         |          4                                                  2     3      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +  +              +                    +                 +   |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                3              2                    1                 2   |             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +  +           +        +     +        +  +                  |             
      Inflammation, Chronic Active         |          2  4              2        4     2                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +  +  +           +        +     +        +  +        +         |             
      Inflammation, Chronic Active         |                                     1     1                              |             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +           +        +     +        +  +                  |             
      Spermatogenic Arrest                 |                                                                          |             
      Germinal Epithelium, Giant Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +     +     +  +     M     +  +     +  +        +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          M  +  M           M        M     M        +  +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  M  +     +     +  +     M     +  +     +  +        +         |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +           +        +     +  +     +  +                  |             
      Depletion Lymphoid                   |          2  2                       2     3                              |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  M  +           +        M     +        +  M                  |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M  M           M        M     M        M  M                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +  +     +        +     +  +     +  +        +         |             
      Inflammation, Chronic Active         |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +     +  +     +     +  +  +  +  +     +  +     +   |             
      Joint, Tarsal, Hyperostosis          | 4  4                 4        4              4  4     4     4  4     4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|             
                                           | 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +  +           +        +     +        +  +     +            |             
      Thalamus, Mineralization             |                                                    1  1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +           +  +     +     +     +  +  +     +  +     +   |             
      Crystals                             |                               1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +           +        +     +        +  +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +           +        +     +        +  +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +           +        +     +        +  +                  |             
      Inflammation, Chronic Active         |    1     1                          2              2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Renal Tubule, Mineralization         |             2                                                            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +  +  +  +     +        A     +        +  +                  |             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |          4                                                               |             
      Inflammation, Chronic Active         |             2     1  1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                            +                       +              +  I   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +                       +        +     +  +   |             
      Infarct                              |                                                                          |             
      Necrosis                             |                            4                                             |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            M                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +                       +              +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +                       +              +  +   |             
      Inflammation, Chronic Active         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +                       +           +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +                       +           +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +                       +              +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +                       +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +                       +        +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +                       +        +     +  +   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +                       M              +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            +                       M              M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +                       M              +  +   |             
      Pars Distalis, Cyst                  |                                                                   1      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +  +  +     +  +  +  +        +     +  +     +  +  M  +   |             
      Inflammation, Chronic                |                      1              1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Inflammation, Acute        |                                                                          |             
      Follicle, Pigmentation               | 2              2  2  2     2  2  2  2        1     1  1     1  1     1   |             
      Follicular Cell, Hyperplasia         | 2              2  1  1        1  1           1     1  1     1  1         |             
      Follicular Cell, Pigmentation        | 2              1  2  1     2  1  1  1        1     1  1     1  1     2   |             
      Interstitium, Pigmentation           | 1              1  1  1     1  1  1  1        1        1     1  1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +  +  +     +  +  +  +        +     +  +     +  +  +  +   |             
      Inflammation, Chronic Active         | 1                                   1        1                           |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +  +                                                   |             
      Abscess                              | 4                 4                                                      |             
      Inflammation, Chronic Active         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +                       +              +  +   |             
      Inflammation, Chronic Active         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                       +  +           +  +   |             
      Inflammation, Chronic Active         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Testes                                  |                            +                       +              +  +   |             
      Spermatogenic Arrest                 |                            1                                             |             
      Germinal Epithelium, Giant Cell      |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +                       +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +  +     +        +     +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            M                       +              +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +        +  +     +        +     +              +  M   |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +                       +           +  +  +   |             
      Depletion Lymphoid                   |                            2                                      1  2   |             
      Hematopoietic Cell Proliferation     |                            3                       2                 2   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            M                       M              +  M   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            M                       M              M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    |                +     +     +  +                    +              +  +   |             
      Inflammation, Chronic Active         |                      1                                               4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +           +  +  +  +        +     +              +  +   |             
      Joint, Tarsal, Hyperostosis          | 4              4              4  4  4        4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|             
                             DAY ON TEST   | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|             
                                           | 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +                       +              +  +   |             
      Thalamus, Mineralization             |                            1                       1                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +  +     +                       +           +  +  +   |             
      Crystals                             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                            M                       +              +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +                       +              +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +                       +  +        +  +  +   |             
      Inflammation, Chronic Active         |                            1                       1  1        1         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Renal Tubule, Mineralization         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            M                       +           +  +  +   |             
      Calculus Micro Observation Only      |                                                                X         |             
      Hemorrhage                           |                                                                   4      |             
      Inflammation, Chronic Active         |                                                                1  4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  A           +           +                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  A           +           A                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  A           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  A           +           M                 +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  M           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  M           +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  A     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  M     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  A     +     +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  M     +     +           M                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +           +           +        +  +     +                  |  22        |
      Infarct                              |                                                                          |      1  3.0|
      Necrosis                             |                         1                                                |      4  2.3|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  M     +     +           M                 +                  |  16        |
      Inflammation, Chronic                |                         1                                                |      1  1.0|
      Vacuolization Cytoplasmic            |                   1     2                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +           +                 +                  |  17        |
      Inflammation, Chronic Active         |          1                          1                 1                  |      7  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +  +        +           +                 +                  |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +           +           +                 +                  |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  A  +        +           A                 +                  |  16        |
      Hyperplasia                          |                2                                                         |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Dysplasia                            |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +           +                 +                  |  17        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  M           +           +                 +                  |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  M           +           +                 +                  |  17        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  M           +           +                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  M     +     +           M                 +                  |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +           M           M                 +                  |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  M           +           +                 +                  |  13        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +     +  +  +  +  +        +  +  +  +                  |  48        |
      Inflammation, Chronic                |                   1        1                 1                           |      7  1.0|
      Follicle, Inflammation, Acute        |                                                                          |      1  1.0|
      Follicle, Pigmentation               | 2  2     1     1  1     2  1  2  1  1        2  2  1  1                  |     44  1.6|
      Follicular Cell, Hyperplasia         | 1              1  1        1  1  1           1     1                     |     27  1.3|
      Follicular Cell, Pigmentation        | 2  2     2     1  1     3  1  2  1  2        2  1  1  2                  |     44  1.5|
      Interstitium, Pigmentation           | 1  1     1     1  1     2  1  1  1  1        1  1  1  1                  |     42  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  A  +  +     +  +  +  +  +        +  +  +  +                  |  47        |
      Inflammation, Chronic Active         |          1                                   1     1                     |     13  1.1|
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                          +           +                        |   8        |
      Inflammation, Chronic Active         |          2                                                               |      4  2.8|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +        +                                                      |  11        |
      Abscess                              |    4                                                                     |      3  4.0|
      Inflammation, Chronic Active         |    1     3        2                                                      |      8  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                |          M  A           +           +                 +                  |  15        |
      Inflammation, Chronic Active         |                                     2                                    |      7  2.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +        +           +        +        +                  |  21        |
      Inflammation, Chronic Active         |          1                                                               |      4  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +           +           +                 +                  |  17        |
      Spermatogenic Arrest                 |                                                                          |      1  1.0|
      Germinal Epithelium, Giant Cell      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  A           +           +                 +                  |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  M  +  +     +  +     +  A              +  +                  |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  M           +           A                 +                  |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     +  M  +  +     M  +     M  M              +  +                  |  24        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  M     +     +        +  A        +        +                  |  21        |
      Depletion Lymphoid                   | 4                                3                                       |      9  2.3|
      Hematopoietic Cell Proliferation     |                                              2        2                  |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +           M           A                 +                  |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1|              |            |
                             DAY ON TEST   | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8|              |            |
                                           | 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    61LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M           M           M                 M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +  +        +  +  +  +  +        +  M  +  +                  |  32        |
      Inflammation, Chronic Active         |                                              1                           |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +  +  +  +     +     +  +  +           +  +  +                  |  39        |
      Joint, Tarsal, Hyperostosis          |    4           4  4     3     4  4              4  4                     |     24  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +           +                 +                  |  18        |
      Thalamus, Mineralization             |                         1                             1                  |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +     +     +     +  +  +              +  +                  |  29        |
      Crystals                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  M           +           I                 +                  |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  A           +           +                 +                  |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  A           +  +     +  +              +  +                  |  22        |
      Inflammation, Chronic Active         |          1              2  1     1  1              1  1                  |     15  1.2|
      Vacuolization Cytoplasmic            |                         2                                                |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             M                                                            |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  A           +        +  A                 +                  |  17        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      5  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  M  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +  +     M  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     M  +  +  +     +  +  +  +  +  M  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  A  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  A  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  A  +     +  +  +  +  M  +  +  +        M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     M  +  A  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Basophilic Focus                     |                                                 2                        |             
      Eosinophilic Focus                   |                                                                          |             
      Necrosis                             | 3                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  1  1                       1  1                                    |             
      Vacuolization Cytoplasmic            | 1                                   3                                    |             
      Duct, Dilatation                     |                                     4                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic Active         |    1  1        1                       1                    1  1  1  1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                | 1                                   1                       1        1   |             
      Mineralization                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                   +           +         |             
      Dysplasia                            |                2                                               2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |                1              1                 1  1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Hyperplasia                          |                                     1        1                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M     M  M  M  M     +  M  M  M  M  M  +  +        M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  M     +  +  +  M  M  +  +  +        +  +  +  M  +|             
      Pars Distalis, Hyperplasia           | 1              1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |       1  2                    2              2  1  1        1  1  1  2   |             
      Follicle, Cyst                       | 2                                                                        |             
      Follicle, Pigmentation               | 2  3  2  2     2  2  1        2  2  2  2     2  3  2        3  2  2  3  2|             
      Follicular Cell, Hyperplasia         | 1  1  2  1     2  1           1  2  2  2     2  2           1  2  1  2   |             
      Follicular Cell, Pigmentation        | 2  3  2  2     2  2  2  2     2  2  2  2     2  3  2        3  2  2  3  2|             
      Interstitium, Pigmentation           | 2  1  2  2     2  2  1  1     1  2  1  2     2  3  2        2  2  2  3  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                             +            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  M     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Granuloma Sperm                      |                                                                         2|             
      Inflammation, Chronic Active         |    1           1     2                             1                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +  +                    +                           |             
      Abscess                              |                4                                                         |             
      Inflammation, Chronic Active         |                      4  4                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +     +  +  +  +     +  M  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic Active         | 1  1     1     1     4        1        1           1           1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic Active         |       1  1     1              1  1  1                       1  1        1|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Spermatogenic Arrest                 |                                                                          |             
      Germinal Epithelium, Giant Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  M  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Depletion Lymphoid                   |                      2  2                                                |             
      Hematopoietic Cell Proliferation     |                      3                             4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  I     +  +  M  A     +  M  +  +  M  +  +  M        M  +  +  M  M|             
      Cyst                                 |                1                                1                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M     M  M  M  M  M  M  M  M        M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  M  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|             
                                           | 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      3                          1           1            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | 4              4              4     4                          3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Thalamus, Mineralization             | 1  1                    1     1        1        1  1                    1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |             
      Bronchiole, Epithelium, Hyperplasia  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
      Inflammation, Acute                  |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +  +  M  +  +  +        +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                            +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Cyst                                 | 2                                                              2         |             
      Hydronephrosis                       | 2                                                                        |             
      Inflammation, Chronic Active         | 2  1  1  1     1  1     1     2  1  1  1     1  1  1        1  2  1     1|             
      Papilla, Mineralization              |                      2                                                   |             
      Renal Tubule, Mineralization         |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic Active         |                1  1  3              1        1     1        1  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +           +  +  +  +     +  +  +  +     +  +  +        M  +         |             
      Inflammation, Chronic                |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +           +  +  +  +     +  +  M  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Inflammation, Chronic                | 2                                                              1         |             
      Vacuolization Cytoplasmic            | 1                             1              1                           |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Inflammation, Chronic Active         |                      1        1  1           1                 1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Inflammation, Chronic                | 1                                               1                        |             
      Mineralization                       |                                     1  1                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Inflammation, Chronic                |                                              1     1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +           M  +  M  M     M  +  M  M     M  M  +        A  M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +  +  +  +     +  M  +  +     +  +  +        A  +         |             
      Pars Distalis, Hyperplasia           |    2                 1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Inflammation, Chronic                | 1  1           1        1     1     1  1     1                 1         |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Pigmentation               | 3  3           2  2  2  3     2  3  3  3     3  2  3        3  3         |             
      Follicular Cell, Hyperplasia         | 2  1           1  2  1  1     1  1  2  2     2  2  2        1            |             
      Follicular Cell, Pigmentation        | 3  3           2  2  2  3     2  3  3  3     3  2  3        3  3         |             
      Interstitium, Pigmentation           | 3  2           2  2  2  3     2  2  2  3     3  2  2        3  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic Active         |    1              1           1        1     1                 1         |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                             +            |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +           +  +  +  I     +  +  +  M     +  +  +        +  +         |             
      Inflammation, Chronic Active         | 1  1              1                          1                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Inflammation, Chronic Active         |                   1                 1                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Spermatogenic Arrest                 |                                                                          |             
      Germinal Epithelium, Giant Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +           +  +  +  +     +  M  +  +     +  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +  +     +  +  +  +     M  +  +        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +           +  +  M  +     +  +  +  +     M  +  M        A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +  +  +     +  +  +  +     M  +  +        M  +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        M  +         |             
      Depletion Lymphoid                   |                      3           2                                       |             
      Hematopoietic Cell Proliferation     |                         3                    3                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +  +  M  M     +  +  M  +     M  +  +        M  M         |             
      Cyst                                 |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M           M  M  M  M     M  M  M  M     M  M  M        M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|             
                             DAY ON TEST   | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|             
                                           | 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.O%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +  +  +  +     +  M  +  +     +  +  +        +  +         |             
      Joint, Tarsal, Hyperostosis          | 3              4                    2              4           4         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Thalamus, Mineralization             |                1  1  1        1  1  1  1     1  1           1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +           +  +  +  +     +  M  +  +     +  +  +        +  +         |             
      Inflammation, Acute                  |                1                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                          +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +           +  +  +  +     +  +  +  +     +  +  +        A  +         |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         | 1  1           1  1     1     1  1  1  1     1  1  1           1         |             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Mineralization         | 1                                            1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  +  +  +     +  +  +  +     +  +  +        +  +         |             
      Calculus Micro Observation Only      |    2                                                                     |             
      Inflammation, Chronic Active         | 1  1           1  1     1     1  1           1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +     +  +  +  +  +     +  M  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +           +  +  +     +  +  +  +  M     +  +  +  +                  |  46        |
      Inflammation, Chronic                |                                     1                 1                  |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +  +  +     +  +  M  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   |    1                                                                     |      1  1.0|
      Necrosis                             |                            1                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +           M                                 |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |                1                    1              1                     |     11  1.1|
      Vacuolization Cytoplasmic            |                                     2           2     2                  |      8  1.6|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic Active         | 1              1     1     1  1     1        1  1                        |     21  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +           +  +  +     +  +  +  +  +        +  +  +                  |  47        |
      Inflammation, Chronic                |    1                                               1                     |      8  1.0|
      Mineralization                       |                                                    1                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +              +        +                  |   6        |
      Dysplasia                            |                               2              2        2                  |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |                      1                                                   |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Hyperplasia                          |    2              1           1                    2                     |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +  +  +     +  +  +  +  +     M  +  +  +                  |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M           +  I  +     +  M  +  +  +     +  M  M  +                  |  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +           +  +  +     M  I  +  +  M     +  +  +  +                  |  40        |
      Pars Distalis, Hyperplasia           |                                  2                    2                  |      6  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic                |                1  1  1        1  1  1  1     1     1  1                  |     29  1.1|
      Follicle, Cyst                       |                                  3                                       |      2  2.5|
      Follicle, Pigmentation               | 2  2           2  3  2     2  2  2  2  1     3  2  3  3                  |     48  2.3|
      Follicular Cell, Hyperplasia         | 2  2           1  1  1        2  2  1        1  1  2                     |     41  1.5|
      Follicular Cell, Pigmentation        | 2  2           2  3  2     2  2  2  2  2     3  2  3  3                  |     49  2.4|
      Interstitium, Pigmentation           | 2  2           2  3  2     2  2  2  2  1     3  2  3  3                  |     49  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   1           1              1                           |     13  1.1|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                        +                                 |   4        |
      Inflammation, Chronic Active         |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                  +           +                           |   6        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                  4           3                           |      4  3.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           M  +  +     +  +  +  +  +     +  +  +  +                  |  45        |
      Inflammation, Chronic Active         |    1              1           1  1  1        1        1                  |     20  1.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Inflammation, Chronic Active         |                               1  1  1                                    |     14  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Spermatogenic Arrest                 |                                        2                                 |      1  2.0|
      Germinal Epithelium, Giant Cell      |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +           +  +  M     M  +  +  +  +     +  M  +  +                  |  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +  +  +     +  +  +  +  +     +  +  +  M                  |  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Depletion Lymphoid                   | 2                                                                        |      5  2.2|
      Hematopoietic Cell Proliferation     |                                        3                                 |      5  3.2|
      Hyperplasia, Lymphoid                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M           +  +  +     +  +  +  +  M     +  M  +  +                  |  29        |
      Cyst                                 |                                                       1                  |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M           M  M  M     M  M  M  M  M     M  M  M  M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +  +  +     +  +  M  +  +     +  +  +  +                  |  48        |
      Inflammation, Chronic Active         |                               1        1                                 |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
      Joint, Tarsal, Hyperostosis          | 4  4           3     4              4              4  4                  |     17  3.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Thalamus, Mineralization             |                            1     1     1     1  1  1  1                  |     25  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |      3  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M           +  +  +     +  +  +  +  +     +  +  +  +                  |  47        |
      Inflammation, Acute                  |                                     1                                    |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  49        |
      Cyst                                 |                   2                                                      |      3  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 1              1  1  1     1  1  1  1  1     1  1  1  1                  |     44  1.1|
      Papilla, Mineralization              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05057-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:50:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4|              |            |
                             DAY ON TEST   | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5|              |            |
                                           | 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.O%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Mineralization         |                                                       1                  |      4  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +  +     +  +  +  +  +     +  +  +  +                  |  50        |
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    1           1           1  1  1           1     1  1                  |     25  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.