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TDMS Study 05057-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            HC YELLOW 4


NTP Experiment-Test: 05057-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 04:26:02




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           15           15                                                  
    Dead                                               2            4            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           30           34                                                  
    Moribund                                           1            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (49)         (49)                                                
      Parasite                                         1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (47)         (47)                                                
      Parasite                                         1 (2%)       1 (2%)                                                          
   Intestine Large, Rectum                            (48)         (46)         (49)                                                
      Parasite                                         2 (4%)       1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                37 (74%)     32 (64%)     41 (82%)                                            
      Clear Cell Focus                                 1 (2%)       3 (6%)       2 (4%)                                             
      Eosinophilic Focus                                            1 (2%)       2 (4%)                                             
      Fatty Change, Diffuse                            7 (14%)      7 (14%)      4 (8%)                                             
      Fatty Change, Focal                              7 (14%)      2 (4%)       3 (6%)                                             
      Hepatodiaphragmatic Nodule                       4 (8%)       3 (6%)       9 (18%)                                            
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Granulomatous                     30 (60%)     22 (44%)     27 (54%)                                            
      Mixed Cell Focus                                 6 (12%)      5 (10%)      7 (14%)                                            
      Necrosis                                                      3 (6%)                                                          
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia                          26 (52%)     24 (48%)     32 (64%)                                            
   Pancreas                                           (49)         (50)         (49)                                                
      Acinus, Atrophy                                  1 (2%)                                                                       
      Duct, Hyperplasia                                             1 (2%)                                                          
   Stomach, Forestomach                               (50)         (48)         (50)                                                
      Acanthosis                                       1 (2%)       7 (15%)      4 (8%)                                             
      Hyperkeratosis                                   2 (4%)       4 (8%)       2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                                         2 (4%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  23 (46%)     28 (56%)     23 (46%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (46)         (49)                                                
      Hyperplasia                                      6 (12%)      3 (7%)       4 (8%)                                             
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Hyperplasia                                                                1 (2%)                                             
      Pars Distalis, Angiectasis                      29 (59%)     28 (58%)     22 (45%)                                            
      Pars Distalis, Cyst                              5 (10%)      5 (10%)      9 (18%)                                            
      Pars Distalis, Hyperplasia                      11 (22%)     14 (29%)     11 (22%)                                            
      Pars Intermedia, Angiectasis                     1 (2%)                                                                       
      Pars Intermedia, Cyst                                                      1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
      C-Cell, Hyperplasia                             10 (20%)     14 (28%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (44)                                                
      Necrosis                                         1 (2%)       4 (9%)                                                          
   Ovary                                              (50)         (49)         (50)                                                
      Cyst                                             2 (4%)       5 (10%)      3 (6%)                                             
   Uterus                                             (48)         (50)         (50)                                                
      Endometrium, Hyperplasia                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                    2 (4%)                                             
   Lymph Node, Mesenteric                             (49)         (50)         (49)                                                
      Degeneration, Cystic                                          1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (49)         (50)                                                
      Fibrosis                                         1 (2%)       2 (4%)                                                          
      Hematopoietic Cell Proliferation                30 (60%)     23 (47%)     31 (62%)                                            
      Infiltration Cellular, Histiocyte                3 (6%)       1 (2%)       1 (2%)                                             
      Pigmentation                                    28 (56%)     15 (31%)     31 (62%)                                            
      Thrombosis                                                    1 (2%)                                                          
   Thymus                                             (47)         (42)         (43)                                                
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (37)         (47)                                                
      Galactocele                                     14 (29%)      7 (19%)      9 (19%)                                            
      Acinus, Hyperplasia                              3 (6%)       6 (16%)      5 (11%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hemorrhage                                       2 (4%)       1 (2%)       2 (4%)                                             
   Spinal Cord                                        (1)                       (2)                                                 
      Hemorrhage                                                                 1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Infiltration Cellular, Histiocyte                9 (18%)     16 (32%)      8 (16%)                                            
      Alveolar Epithelium, Hyperplasia                                           3 (6%)                                             
   Nose                                               (50)         (49)         (48)                                                
      Fungus                                                        1 (2%)                                                          
      Inflammation, Acute                              2 (4%)       2 (4%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (12)         (8)          (17)                                                
      Hemorrhage                                       1 (8%)                    1 (6%)                                             
      Inflammation, Acute                              2 (17%)      2 (25%)                                                         
      Lens, Cataract                                   5 (42%)      7 (88%)      8 (47%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Atrophy                                  1 (8%)       1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Nephropathy                                     37 (76%)     44 (88%)     41 (82%)                                            
   Urinary Bladder                                    (48)         (48)         (50)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 19           20           20                                                  
  Early Deaths                                                                                                                      
    Moribund                                          24           17           18                                                  
    Dead                                               6            4            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           29           28                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    50           50           49                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (48)         (46)                                                
      Parasite                                         1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (44)         (45)                                                
      Diverticulum                                     1 (2%)                                                                       
      Parasite                                         4 (8%)                    5 (11%)                                            
   Intestine Large, Rectum                            (47)         (47)         (47)                                                
      Parasite                                         1 (2%)                    2 (4%)                                             
      Thrombosis                                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)                                                
      Angiectasis                                      4 (8%)       1 (2%)       4 (8%)                                             
      Angiectasis, Focal                               1 (2%)                    1 (2%)                                             
      Basophilic Focus                                17 (34%)     21 (42%)     16 (33%)                                            
      Clear Cell Focus                                 6 (12%)      5 (10%)     10 (20%)                                            
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             2 (4%)       3 (6%)       4 (8%)                                             
      Eosinophilic Focus                               5 (10%)      2 (4%)       6 (12%)                                            
      Fatty Change, Diffuse                            3 (6%)                    1 (2%)                                             
      Fatty Change, Focal                              9 (18%)      8 (16%)      3 (6%)                                             
      Hepatodiaphragmatic Nodule                       7 (14%)      4 (8%)       5 (10%)                                            
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       3 (6%)       1 (2%)                                             
      Necrosis                                         1 (2%)       3 (6%)       3 (6%)                                             
      Thrombosis                                       3 (6%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          34 (68%)     36 (72%)     41 (84%)                                            
   Mesentery                                          (3)          (5)          (1)                                                 
      Fat, Inflammation, Chronic Active                                          1 (100%)                                           
      Fat, Necrosis                                    2 (67%)                   1 (100%)                                           
   Pancreas                                           (50)         (48)         (48)                                                
      Acinus, Atrophy                                 22 (44%)     21 (44%)     23 (48%)                                            
      Acinus, Basophilic Focus                         5 (10%)      1 (2%)       3 (6%)                                             
      Acinus, Hyperplasia                              1 (2%)       3 (6%)       5 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Fibrosis                                                           4 (8%)                                             
      Artery, Inflammation, Chronic Active                                       2 (4%)                                             
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (48)         (49)                                                
      Acanthosis                                       2 (4%)       2 (4%)                                                          
      Hyperkeratosis                                   1 (2%)       1 (2%)       1 (2%)                                             
      Necrosis                                                      3 (6%)       1 (2%)                                             
   Stomach, Glandular                                 (49)         (48)         (48)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Mineralization                                   3 (6%)                    1 (2%)                                             
      Necrosis                                         2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
      Cardiomyopathy                                  33 (66%)     42 (84%)     34 (69%)                                            
      Thrombosis                                                    2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (48)                                                
      Hyperplasia                                                                3 (6%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (48)                                                
      Hyperplasia                                     12 (24%)     16 (33%)     14 (29%)                                            
   Islets, Pancreatic                                 (48)         (47)         (48)                                                
      Hyperplasia                                                   3 (6%)                                                          
   Parathyroid Gland                                  (47)         (44)         (37)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (3%)                                             
   Pituitary Gland                                    (45)         (49)         (49)                                                
      Pars Distalis, Angiectasis                       8 (18%)     11 (22%)     10 (20%)                                            
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       3 (6%)                                             
      Pars Distalis, Hyperplasia                       8 (18%)     13 (27%)     18 (37%)                                            
      Pars Intermedia, Cyst                                                      1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (48)                                                
      C-Cell, Hyperplasia                              4 (8%)       9 (18%)      6 (13%)                                            
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (49)                                                
      Granuloma Sperm                                                            1 (2%)                                             
   Preputial Gland                                    (48)         (50)         (49)                                                
      Inflammation, Chronic Active                    11 (23%)      6 (12%)      5 (10%)                                            
   Prostate                                           (48)         (49)         (46)                                                
      Epithelium, Hyperplasia                          4 (8%)       1 (2%)       2 (4%)                                             
   Testes                                             (50)         (50)         (49)                                                
      Interstitial Cell, Hyperplasia                  20 (40%)     27 (54%)     29 (59%)                                            
      Seminiferous Tubule, Atrophy                    34 (68%)     31 (62%)     21 (43%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (49)                                                
      Mediastinal, Fibrosis                                                      1 (2%)                                             
      Renal, Pigmentation                              1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (47)                                                
      Fibrosis                                         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               10 (20%)      3 (6%)       7 (15%)                                            
   Spleen                                             (50)         (50)         (48)                                                
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                         4 (8%)       2 (4%)       5 (10%)                                            
      Hematopoietic Cell Proliferation                20 (40%)     12 (24%)     25 (52%)                                            
   Thymus                                             (41)         (43)         (47)                                                
      Cyst                                                                       1 (2%)                                             
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (28)         (18)         (26)                                                
      Galactocele                                      2 (7%)       2 (11%)      2 (8%)                                             
      Acinus, Hyperplasia                              7 (25%)      6 (33%)      5 (19%)                                            
   Skin                                               (48)         (50)         (47)                                                
      Acanthosis                                       1 (2%)                    1 (2%)                                             
      Cyst Epithelial Inclusion                        2 (4%)                    3 (6%)                                             
      Hyperkeratosis                                   2 (4%)       2 (4%)       4 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05057-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:26:02  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Hemorrhage                                       2 (4%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Fibrosis                                         2 (4%)                    2 (4%)                                             
      Infiltration Cellular, Histiocyte                6 (12%)      6 (12%)      5 (10%)                                            
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Metaplasia, Osseous                                           1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              4 (8%)       2 (4%)                                             
   Nose                                               (47)         (50)         (49)                                                
      Fungus                                           2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute                              4 (9%)       4 (8%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (6)          (4)          (2)                                                 
      Inflammation, Acute                              1 (17%)                                                                      
   Eye                                                (6)          (6)          (12)                                                
      Hemorrhage                                       1 (17%)                                                                      
      Lens, Cataract                                   4 (67%)      4 (67%)      6 (50%)                                            
      Retina, Atrophy                                  2 (33%)                   3 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Cyst                                             3 (6%)       2 (4%)       4 (8%)                                             
      Hydronephrosis                                                             2 (4%)                                             
      Nephropathy                                     49 (98%)     49 (98%)     47 (96%)                                            
   Urinary Bladder                                    (48)         (48)         (47)                                                
      Calculus Gross Observation                                                 1 (2%)                                             
      Calculus Micro Observation Only                  2 (4%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
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