National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2391

TDMS Study 05057-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            HC YELLOW 4


NTP Experiment-Test: 05057-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 04:27:24




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 20           20           20                                                  
  Early Deaths                                                                                                                      
    Moribund                                          21           15           15                                                  
    Dead                                               2            4            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           30           34                                                  
    Moribund                                           1            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (49)         (49)                                                
   Intestine Large, Colon                             (48)         (47)         (47)                                                
   Intestine Large, Rectum                            (48)         (46)         (49)                                                
   Intestine Small, Duodenum                          (49)         (48)         (49)                                                
   Intestine Small, Ileum                             (49)         (47)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Ovary                                  1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                          (3)          (4)          (6)                                                 
      Carcinoma, Metastatic, Ovary                                  1 (25%)                                                         
   Pancreas                                           (49)         (50)         (49)                                                
      Acinus, Adenoma                                  2 (4%)       2 (4%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (48)         (50)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (46)         (49)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          1 (2%)       3 (7%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (48)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (46)         (39)         (45)                                                
      Adenoma                                          1 (2%)       1 (3%)                                                          
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Pars Distalis, Adenoma                          31 (63%)     31 (65%)     29 (59%)                                            
      Pars Distalis, Adenoma, Multiple                 2 (4%)       4 (8%)       1 (2%)                                             
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  9 (18%)      7 (14%)      7 (14%)                                            
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (44)                                                
      Adenoma                                          6 (13%)      5 (11%)      2 (5%)                                             
      Carcinoma                                                                  2 (5%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (49)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
   Uterus                                             (48)         (50)         (50)                                                
      Polyp Stromal                                    4 (8%)       7 (14%)     12 (24%)                                            
      Polyp Stromal, Multiple                                       1 (2%)                                                          
      Sarcoma Stromal                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Carcinoma, Metastatic, Ovary                     1 (2%)                                                          
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                        1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)         (45)         (48)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (50)         (49)                                                
   Spleen                                             (50)         (49)         (50)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (47)         (42)         (43)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (37)         (47)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          3 (6%)                    2 (4%)                                             
      Fibroadenoma                                    19 (40%)     16 (43%)     16 (34%)                                            
      Fibroadenoma, Multiple                           9 (19%)      3 (8%)       2 (4%)                                             
   Skin                                               (48)         (50)         (49)                                                
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Carcinoma Adenosquamous                                       1 (2%)                                                          
      Keratoacanthoma                                               1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (1)                       (2)                                                 
      Neoplasm NOS                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Carcinoma Adenosquamous, Metastatic, Skin                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Nose        1 (2%)                                                                       
   Nose                                               (50)         (49)         (48)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (3)          (3)                                                 
      Fibroma                                          1 (50%)                                                                      
      Squamous Cell Papilloma                                                    1 (33%)                                            
   Harderian Gland                                    (9)          (4)          (15)                                                
      Adenoma                                          1 (11%)                   1 (7%)                                             
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
   Urinary Bladder                                    (48)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            14 (28%)     15 (30%)     10 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATE     0.5%         1.0%                                                   
                                                   D 61UF       61LF         61HF                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          48                                                   
     Total Primary Neoplasms                          119         106          96                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          48          43                                                   
     Total Benign Neoplasms                            96          88          83                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          18          13                                                   
     Total Malignant Neoplasms                         22          18          13                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2                                                               
     Total Metastatic Neoplasm                          5           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 19           20           20                                                  
  Early Deaths                                                                                                                      
    Moribund                                          24           17           18                                                  
    Dead                                               6            4            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           29           28                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    50           50           49                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (48)         (49)                                                
   Intestine Large, Cecum                             (47)         (48)         (46)                                                
   Intestine Large, Colon                             (48)         (44)         (45)                                                
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Duodenum                          (47)         (48)         (47)                                                
   Intestine Small, Ileum                             (45)         (48)         (46)                                                
   Intestine Small, Jejunum                           (46)         (47)         (46)                                                
      Sarcoma                                                                    1 (2%)                                             
   Liver                                              (50)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Lung                                           1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (3)          (5)          (1)                                                 
   Pancreas                                           (50)         (48)         (48)                                                
      Acinus, Adenoma                                  1 (2%)       3 (6%)       2 (4%)                                             
      Acinus, Adenoma, Multiple                        1 (2%)       1 (2%)                                                          
   Pharynx                                            (1)                                                                           
      Palate, Squamous Cell Papilloma                  1 (100%)                                                                     
   Salivary Glands                                    (49)         (50)         (48)                                                
      Sarcoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (48)         (49)                                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (48)         (48)                                                
   Tongue                                                                       (3)                                                 
      Squamous Cell Papilloma                                                    2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (48)                                                
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (49)         (48)                                                
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)                                                          
      Pheochromocytoma Benign                         13 (26%)     11 (22%)     14 (29%)                                            
      Bilateral, Pheochromocytoma Benign               6 (12%)      6 (12%)      2 (4%)                                             
   Islets, Pancreatic                                 (48)         (47)         (48)                                                
      Adenoma                                          1 (2%)       4 (9%)       3 (6%)                                             
   Parathyroid Gland                                  (47)         (44)         (37)                                                
      Adenoma                                                                    2 (5%)                                             
   Pituitary Gland                                    (45)         (49)         (49)                                                
      Pars Distalis, Adenoma                          17 (38%)     18 (37%)     26 (53%)                                            
      Pars Distalis, Adenoma, Multiple                              2 (4%)       2 (4%)                                             
   Thyroid Gland                                      (49)         (49)         (48)                                                
      C-Cell, Adenoma                                  6 (12%)      5 (10%)      6 (13%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (49)                                                
   Preputial Gland                                    (48)         (50)         (49)                                                
      Adenoma                                          8 (17%)     13 (26%)      7 (14%)                                            
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)                    1 (2%)                                             
   Prostate                                           (48)         (49)         (46)                                                
   Seminal Vesicle                                    (48)         (50)         (48)                                                
   Testes                                             (50)         (50)         (49)                                                
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     40 (80%)     36 (73%)                                            
      Interstitial Cell, Adenoma                      10 (20%)      3 (6%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (48)                                                
   Lymph Node                                         (50)         (50)         (49)                                                
   Lymph Node, Mandibular                             (46)         (46)         (46)                                                
   Lymph Node, Mesenteric                             (49)         (50)         (47)                                                
   Spleen                                             (50)         (50)         (48)                                                
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (41)         (43)         (47)                                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (28)         (18)         (26)                                                
      Adenoma                                          1 (4%)                    1 (4%)                                             
      Fibroadenoma                                     3 (11%)      1 (6%)                                                          
   Skin                                               (48)         (50)         (47)                                                
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                               1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  5 (10%)                                                         
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (2%)       3 (6%)                                             
      Carcinoma, Metastatic, Adrenal Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
                                                             Page   9                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                             1 (2%)                                                          
      Mediastinum, Adenocarcinoma, Metastatic, Lung                              1 (2%)                                             
      Mediastinum, Sarcoma, Metastatic, Salivary                                                                                    
          Glands                                                    1 (2%)                                                          
   Nose                                               (47)         (50)         (49)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (6)          (4)          (2)                                                 
      Squamous Cell Carcinoma                                       1 (25%)                                                         
      Squamous Cell Papilloma                          1 (17%)                                                                      
   Harderian Gland                                    (1)          (1)          (6)                                                 
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Lung                                           1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (48)         (48)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)                                                
      Leukemia Mononuclear                            19 (38%)     21 (42%)     16 (33%)                                            
      Lymphoma Malignant Undifferentiated Cell                      2 (4%)       1 (2%)                                             
      Mesothelioma Malignant                           2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05057-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 04:27:24  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATE     0.25%        0.5%                                                   
                                                   D 61 UM       61LM        61HM                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          48                                                   
     Total Primary Neoplasms                          143         148         136                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          48                                                   
     Total Benign Neoplasms                           115         119         114                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          27          19                                                   
     Total Malignant Neoplasms                         28          29          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           3           1                                                   
     Total Metastatic Neoplasm                          4           3           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.