https://ntp.niehs.nih.gov/go/2395

TDMS Study 05057-01 Pathology Tables

NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97
Route: DOSED FEED                                                                                                 Time: 16:37:44
       Facility:  TSI Mason Research
       Chemical CAS #:  5982043-8
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
                                                              Page   1
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +     +     +  +        +     M     +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Basophilic Focus                     | X  X  X  X  X        X        X        X        X     X     X  X         |             
      Clear Cell Focus                     |                               X                                          |             
      Fatty Change, Diffuse                |                                     2  2                                4|             
      Fatty Change, Focal                  |             2           2                                                |             
      Hepatodiaphragmatic Nodule           | X                                      X                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          | 2  2  1  1  1        1  1     1     2  2        1     1     1  1     1   |             
      Mixed Cell Focus                     |             X                       X                                    |             
      Bile Duct, Hyperplasia               | 2     1     2                          2              2     1           2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Acinus, Atrophy                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Acanthosis                           |                                        2                                 |             
      Hyperkeratosis                       |                                     3  3                                 |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Cardiomyopathy                       |    2  2  2                    2     2  1                             1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Hyperplasia                          |             1        1              2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +     M     +  M        +     M     +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Pars Distalis, Angiectasis           | 2  2  2  2  3        2  2     2     3  2        2     2        2     2   |             
      Pars Distalis, Cyst                  |                                                                      2  2|             
      Pars Distalis, Hyperplasia           | 2                                                           2        1   |             
      Pars Intermedia, Angiectasis         |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      C-Cell, Hyperplasia                  |             1           2              1        1           1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  M     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Fibrosis                             |                                                       2                  |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2        2  2     2                 3           2  3     3   |             
      Infiltration Cellular, Histiocyte    | 3                                                                        |             
      Pigmentation                         | 3  3  2  2  2        2  2     3     3  3                    2  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        M  +     +     M  +        +     +     +  +     +  +|             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Galactocele                          |    X        X           X     X                                X         |             
      Acinus, Hyperplasia                  |                                                                      2  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Infiltration Cellular, Histiocyte    |          1  2        1        2                                1     1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Inflammation, Acute                  |             2                                                        1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |             4                                                            |             
      Lens, Cataract                       |                         2                                                |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  1  2  2  2           1     2     3  1        1           2  2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
      Parasite                             |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     +  +  M  +  +  +  +  +     +  +     +  +     +|             
      Parasite                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Basophilic Focus                     | X     X        X              X  X  X     1  X  X     X        X  X     X|             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change, Diffuse                |          2  3                                                            |             
      Fatty Change, Focal                  | 1                                   2                 1                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          | 1                    2        1     3  1     1        2           1      |             
      Mixed Cell Focus                     | X     X                             X                                    |             
      Bile Duct, Hyperplasia               | 1     3  2  1        2     1     2  2  1        1        2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Cardiomyopathy                       | 2     2  2                 1     2        2  2  2     2                 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Hyperplasia                          |                                  1                                      1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Pars Distalis, Angiectasis           | 2                             2     2  2  2           3        2         |             
      Pars Distalis, Cyst                  |             1                                            X               |             
      Pars Distalis, Hyperplasia           |       3        2                 2     2        2                        |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      C-Cell, Hyperplasia                  |                               1  1  1                 1  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M     +  +  +  +     +     +  +  +  +  +  M  +  +     +  +     +  +     +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     M  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     M  +     +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2     2  2     2              2     2  2     2  2     2        2         |             
      Infiltration Cellular, Histiocyte    | 3                                                     3                  |             
      Pigmentation                         |       3        2     2        3     2  2     2                 2  3     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Epithelial Cell, Hyperplasia         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     +     M  +  +  +  +  +  +  +     +  +     +  +     +|             
      Galactocele                          |       X        X              X     X                 X  X               |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Infiltration Cellular, Histiocyte    |                                  1     1  1                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +           +           +     +  +                              |             
      Hemorrhage                           |       1                                                                  |             
      Inflammation, Acute                  |       2                                                                  |             
      Lens, Cataract                       |          2           2           3                                       |             
      Retina, Atrophy                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +           +           +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1     2  3     2     1     1  1  1  2        1  2     2  1     1  2     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  A  M        +  +     +  +  +                  |  48        |
      Parasite                             |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
      Parasite                             |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Basophilic Focus                     | X  X  X  X  1  X     X     1  X        2  1        X                     |     37  1.2|
      Clear Cell Focus                     |                                                                          |      1     |
      Fatty Change, Diffuse                |          2                                            2                  |      7  2.4|
      Fatty Change, Focal                  |       2     2                                                            |      7  1.7|
      Hepatodiaphragmatic Nodule           | X                          X                                             |      4     |
      Hyperplasia                          |                                        2                                 |      1  2.0|
      Inflammation, Granulomatous          |    1  1     1        1  1              1           1                     |     30  1.3|
      Mixed Cell Focus                     |                X                                                         |      6     |
      Bile Duct, Hyperplasia               |       2  2  1        1  1  1           1  1                              |     26  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      2  3.0|
      Mineralization                       |             3                                                            |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Cardiomyopathy                       | 2           1        2     1           2           2                     |     23  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  49        |
      Hyperplasia                          |       2                                                                  |      6  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +     +  +  +  M        +  +     +  +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Pars Distalis, Angiectasis           | 2  2     3     2        2     3                    3  2                  |     29  2.2|
      Pars Distalis, Cyst                  |                                           X                              |      5  1.7|
      Pars Distalis, Hyperplasia           | 2     2                                2                                 |     11  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     10  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  47        |
      Necrosis                             |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Cyst                                 |                                           X                              |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
      Infiltration Cellular, Histiocyte    |                            2              1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  2           2     2        2        2              1                  |     30  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  3.0|
      Pigmentation                         | 2  2           2     2  2                          2                     |     28  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
      Galactocele                          | X  X                          X                                          |     14     |
      Acinus, Hyperplasia                  |                            2                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  M  +  +        +  +     M  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Hemorrhage                           |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      9  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Inflammation, Acute                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                    +     +                                          |  12        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Lens, Cataract                       |    2                                                                     |      5  2.2|
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                          +                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Cyst                                 |                                        X                                 |      1     |
      Nephropathy                          | 3  1        2  2     2  2     2        3           2                     |     37  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  M  A|             
      Parasite                             |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +        +        +     M  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +        M        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A     +  +  +        +        +     +  +  +     M  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X              X                       X           X  X  X      |             
      Clear Cell Focus                     |                                  X                          X            |             
      Eosinophilic Focus                   |    X                                                                     |             
      Fatty Change, Diffuse                |                                           3        2                 2   |             
      Fatty Change, Focal                  |             3                                                            |             
      Hepatodiaphragmatic Nodule           |    X                                               X                     |             
      Inflammation, Granulomatous          |    1                                            1           1  1  1      |             
      Mixed Cell Focus                     |                      X                                            X      |             
      Necrosis                             |                                                                         2|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |             1                    1        1     2  2           2  1  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Duct, Hyperplasia                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Acanthosis                           |                                                 2  2                     |             
      Hyperkeratosis                       |                                  2                 2                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2           2           2                             2        2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |             2                             1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +        +        M     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M     +  +  +        +        M     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  M  +  +|             
      Pars Distalis, Angiectasis           |    2  2     2     2              3              2     3     2  3     3   |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |    2     2  1     2  2  3                                               2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      C-Cell, Hyperplasia                  |          2        2     1                 1                       2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +        +        +     +  M  +     +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Fibrosis                             |                                                    3                     |             
      Hematopoietic Cell Proliferation     | 2  2  2                                         2              2  2      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |    2  2  2                                      2              2         |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  M        +        +     +  +  +     +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +  +  +        +        +     M  +  +     +  +  M  +  +|             
      Galactocele                          |    X  X                                            X                     |             
      Acinus, Hyperplasia                  |    2        2                             2           3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1        3     1                       1                    2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +        +  +                    I        +                     |             
      Inflammation, Acute                  |                                                    1                     |             
      Lens, Cataract                       |    2              2  2                             2                     |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +        +  +                             +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Nephropathy                          | 3     1     1     2  2  1        2        1     2           2  1  1  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
      Parasite                             |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     | X        X     X        X     X        X     X  X  X     1  X           1|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |             2              2                          2                  |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation, Granulomatous          | 2        1              1     1        1  1  1  2  1     1  1     1      |             
      Mixed Cell Focus                     |                                                 X           X            |             
      Necrosis                             |                                                 1                        |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1              2                       2  1  1  1  2        1  2  1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +        +  +  +        +  +  +  +  +  M  +  +  +  +     M|             
      Acanthosis                           |             2           2  2                                1            |             
      Hyperkeratosis                       |             2                                                            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy                       | 2        2                             2  2  2  2           2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +        +  +  +        +  +  +  +  +  +  I  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +        +  +  +        +  +  +  M  +  +  M  M  M  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           | 2           2  3           2  3        2  2  3  2     2        2  2      |             
      Pars Distalis, Cyst                  |          X                                               2               |             
      Pars Distalis, Hyperplasia           |          2  2           2  2                                   2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                2                                                         |             
      C-Cell, Hyperplasia                  |          1              2     2        1                 1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +        +  +  +        M  +  +  +  +  +  +  +  +  +     +|             
      Necrosis                             |                2           3                       2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                        X     X                 X  X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +        +  +  +        +  +  +  +  M  M  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Degeneration, Cystic                 |                                        3                                 |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     | 2              2              2        2     2     2  3  4               |             
      Infiltration Cellular, Histiocyte    |                         3                                                |             
      Pigmentation                         |                3                          2  3  2           2            |             
      Thrombosis                           |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        M  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        +  M  +        M  +  +        +  M  M  M  +  +  +  +  +  M     +|             
      Galactocele                          |                            X           X                                 |             
      Acinus, Hyperplasia                  |                                                          2              4|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Histiocyte    |                                              1  1        1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                    +      |             
      Inflammation, Acute                  |                                                                          |             
      Lens, Cataract                       |                                              3                    3      |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Nephropathy                          | 1        1  2  3        2  1  2        1  2  2  2  1  2  1  2  1  2     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  46        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Basophilic Focus                     | X           1  X  X     X     X  X     X     X  X     X                  |     32  1.0|
      Clear Cell Focus                     |                                                       X                  |      3     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |                                           4                              |      7  2.4|
      Fatty Change, Focal                  |          2                                                               |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation, Granulomatous          | 1     1           1           1              1                           |     22  1.1|
      Mixed Cell Focus                     |       X                                                                  |      5     |
      Necrosis                             |                                        2                                 |      3  1.7|
      Thrombosis                           |                                        3                                 |      1  3.0|
      Bile Duct, Hyperplasia               | 1        2        2           1                       2                  |     24  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                    +        +                        |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
      Acanthosis                           |                                           2                              |      7  1.9|
      Hyperkeratosis                       |                                           2                              |      4  2.0|
      Ulcer                                |                                        2  1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Cardiomyopathy                       | 2     2  2  1  2  2              2     2     2  2     3                  |     28  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +     +     +  +     +  M  +  M     +                  |  46        |
      Hyperplasia                          |          2              2                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  M  +     +     +  +     +  M  +  M     +                  |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  48        |
      Pars Distalis, Angiectasis           |                2              2  2     2        2     3                  |     28  2.3|
      Pars Distalis, Cyst                  |                X        X                                                |      5  2.0|
      Pars Distalis, Hyperplasia           |                   2           2                                          |     14  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |          2  2     1                       1                              |     14  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
      Necrosis                             |       2                                                                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  49        |
      Cyst                                 |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Endometrium, Hyperplasia             |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M     +  +  +  +  +     M     +  +     +  +  +  +     +                  |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     | 2              2  2     3        2     3     2  2     2                  |     23  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Pigmentation                         | 2     2                       3  2                    2                  |     15  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  M  +  +     +     M  +     +  M  M  +     +                  |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  M  +  +  +     +     +  +     +  +  +  M     M                  |  37        |
      Galactocele                          |             2                    X                                       |      7  2.0|
      Acinus, Hyperplasia                  |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Hemorrhage                           |                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Infiltration Cellular, Histiocyte    |       1        1        1     1  1        1  1  1                        |     16  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  49        |
      Fungus                               |             4                                                            |      1  4.0|
      Inflammation, Acute                  |             3                             1                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   8        |
      Inflammation, Acute                  |                                           4                              |      2  2.5|
      Lens, Cataract                       |                                           4                              |      7  2.6|
      Retina, Atrophy                      |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Nephropathy                          | 1     1  2  1  1  1     1        2     2  1  2  2     2                  |     44  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  M  +     +  +  M     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  M  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Basophilic Focus                     | X     X        X  X  X        X  X  X     X  X  X     X           X     1|             
      Clear Cell Focus                     |       X                                                                  |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |          4                                                               |             
      Fatty Change, Focal                  |                      2  2                                                |             
      Hepatodiaphragmatic Nodule           |       X           X  X                                                   |             
      Inflammation, Granulomatous          | 1     2              3        1  1  1     1  1        2           1     2|             
      Mixed Cell Focus                     |                      X        X                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2           1     2  2     2  3  1        2  2                 2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Cardiomyopathy                       | 2  2                          2           2              2        2     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     M  +  +  +     +  +  +     +  +  +     +  M        +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hyperplasia                          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |    2           3     3           2  2                 2  2               |             
      Pars Distalis, Cyst                  |       X  1              1                 X     X                        |             
      Pars Distalis, Hyperplasia           |       2                                   2              2               |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      C-Cell, Hyperplasia                  | 1                                   1                 2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  M  +     M  +  M     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  M        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  M     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Degeneration, Cystic                 |                                           3                              |             
      Infiltration Cellular, Histiocyte    |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hematopoietic Cell Proliferation     | 2              3  2  2        2     2     3  2  2     2                  |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                2     3        2  2  2        2  3     2  3        2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  M  +     M  +  +     +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Galactocele                          |                      X           X                                      3|             
      Acinus, Hyperplasia                  |          3              1                                               3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Hemorrhage                           |                         2                                               3|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Hemorrhage                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Infiltration Cellular, Histiocyte    |          1              1                 1  1                           |             
      Alveolar Epithelium, Hyperplasia     |                         1                                         2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +     +  M  +     +  +        +     +|             
      Inflammation, Acute                  | 1              1                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                       +|             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  I     +     +              +     +                              |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |       2              2              2                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +        +     +              +     +                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Nephropathy                          | 1     1        2  2  2        1  1  1        2  1     1  2        1     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Basophilic Focus                     | X  X  X  X     X              X  X  X  X  X     X     X  X  X  X     X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                          X               |             
      Fatty Change, Diffuse                |                   2        2                                             |             
      Fatty Change, Focal                  |                                                                         3|             
      Hepatodiaphragmatic Nodule           |          X                                      X     X                  |             
      Inflammation, Granulomatous          | 3  1  1  1                                1  1        1  1  1  2     1  1|             
      Mixed Cell Focus                     |    X                                                        X  X         |             
      Thrombosis                           | X                                                                        |             
      Bile Duct, Hyperplasia               | 2  2  2           2        2  2  2  1           2     2     1  2        2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Acanthosis                           |                            2                                            2|             
      Hyperkeratosis                       |                            2                                            3|             
      Ulcer                                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Cardiomyopathy                       | 2  2  2        2           2  2  2  2     2           2        2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |             1                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |                            1     1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           | 3     3                       2  2        2  2           3  2        2   |             
      Pars Distalis, Cyst                  |             X                                                        X   |             
      Pars Distalis, Hyperplasia           |          2        2        2  2        3              2              1   |             
      Pars Intermedia, Cyst                |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  |          1                          2        1              1        2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Cyst                                 |                                  X                          X  X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                       2        2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2     4                 2  2  2  2  3  2  2     2  2  2        2  2|             
      Infiltration Cellular, Histiocyte    |                                                                3         |             
      Pigmentation                         | 2  2  2  3     2              2  2  2  2     2  2     2  2  2  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     M  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +        +  +  +  +  +  +  +  M     +  +  +  +     +  +|             
      Galactocele                          | X                                                     X     X  X     X   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Infiltration Cellular, Histiocyte    |          1  1  1                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                      +        +           +  +|             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |          3                                               2               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                      +        +           +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Nephropathy                          | 1  1  2     1  1  1        1  1  1  1  2  1  1  1     3  1  1  1        3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Transitional Epithelium, Hyperplasia |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +           +           +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Basophilic Focus                     |    X  X  X  X  X     X  1     X           X           X                  |     41  1.0|
      Clear Cell Focus                     |       X                                                                  |      2     |
      Eosinophilic Focus                   |                                           X                              |      2     |
      Fatty Change, Diffuse                |                            4                                             |      4  3.0|
      Fatty Change, Focal                  |                                                                          |      3  2.3|
      Hepatodiaphragmatic Nodule           |             X                 X           X                              |      9     |
      Inflammation, Granulomatous          |    1  1     2           2                                                |     27  1.4|
      Mixed Cell Focus                     |       X                       X                                          |      7     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    2  2  2  2        2  1                 2                              |     32  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +                                                         |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Acanthosis                           |                2           2                                             |      4  2.0|
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Cardiomyopathy                       |    2     2                 1  2           2                              |     23  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Hyperplasia                          |       2                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                               1                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +  +  +  +     +  +  +  +           +           +                  |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |          2     2     2     2  3                       3                  |     22  2.3|
      Pars Distalis, Cyst                  |    X                       1                                             |      9  1.0|
      Pars Distalis, Hyperplasia           |          2                                                               |     11  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      C-Cell, Hyperplasia                  |                         1  1                          1                  |     11  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +     +  +  +  +           +           +                  |  44        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Endometrium, Hyperplasia             |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  M  +  +           +           +                  |  49        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Hematopoietic Cell Proliferation     |    2        2  2                          2           2                  |     31  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Pigmentation                         |    2  2     2  2                          2           2                  |     31  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  +  +     +  M  +  +           +           +                  |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  M  +     +  +  +  +           +           +                  |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                               X                                          |      9  3.0|
      Acinus, Hyperplasia                  |                         3  2                                             |      5  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  M  +     +  +  +  +           +           +                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Hyperostosis                         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Infiltration Cellular, Histiocyte    |                1                                                         |      8  1.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
      Inflammation, Acute                  |       1                                               2                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +  +        +                 +           +                  |  17        |
      Hemorrhage                           |                2                                                         |      1  2.0|
      Lens, Cataract                       |          2     2                                      2                  |      8  2.1|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +                             +           +                  |  15        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Nephropathy                          |    1  1     1  2           1  2           2           2                  |     41  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +     +        +  +     M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
      Diverticulum                         |                                                                          |             
      Parasite                             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
      Parasite                             |                         2                                                |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                1         |             
      Basophilic Focus                     | X  X  X        X              X                                          |             
      Clear Cell Focus                     | X     X                                                                  |             
      Cyst                                 |                                                                X         |             
      Degeneration, Cystic                 |                   1                                                      |             
      Eosinophilic Focus                   |                X                                                         |             
      Fatty Change, Diffuse                |                                           2                              |             
      Fatty Change, Focal                  |                   2        3                          1           2  2   |             
      Hepatodiaphragmatic Nodule           |                X              X           X                              |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                             3            |             
      Thrombosis                           |                      1     3              2                              |             
      Bile Duct, Hyperplasia               | 2  2  2        2  3  2  2  3  2           2        2           2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Acinus, Atrophy                      | 2              2  2  2  2  2  1  2                 2  2           2      |             
      Acinus, Basophilic Focus             |    X  X                                                                  |             
      Acinus, Hyperplasia                  | 2                                                                        |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                   2  2                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Cardiomyopathy                       |    2           2        1           2     2           2     2        2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Hyperplasia                          |                2                    2                          2  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                     2                          2     2   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
      C-Cell, Hyperplasia                  |                               3  2                             1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Inflammation, Chronic Active         |                      2  2  2                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Epithelium, Hyperplasia              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Interstitial Cell, Hyperplasia       | 2                       1  1  2                       2              2   |             
      Seminiferous Tubule, Atrophy         | 2     2           4  2        2  2  3     3        3  3     3  3  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Renal, Pigmentation                  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  M  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                           2                              |             
      Infiltration Cellular, Histiocyte    |                         2  1                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Fibrosis                             |                                           3                              |             
      Hematopoietic Cell Proliferation     |    2  2              2        2  3                 2  3        3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M        +  M  +  +  M  +  M  +     +        +  +     M  +  M  +   |             
      Galactocele                          |                               X                                          |             
      Acinus, Hyperplasia                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                      X   |             
      Hyperkeratosis                       |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Hemorrhage                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Fibrosis                             |                                                                2         |             
      Infiltration Cellular, Histiocyte    |                            1                                             |             
      Inflammation, Acute                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Fungus                               |    2                                                                     |             
      Inflammation, Acute                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
      Inflammation, Acute                  |                         1                                                |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                                                |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                   2                                                      |             
      Retina, Atrophy                      |                         4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Cyst                                 |                                                                X         |             
      Nephropathy                          | 3  3  3        4  2  2  3  3  3  2  2     2        2  3        3  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
      Parasite                             |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Diverticulum                         |                      3                                                   |             
      Parasite                             |                      2     1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
      Parasite                             |                                                                          |             
      Thrombosis                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |    2                                                                     |             
      Basophilic Focus                     |                            1  X  X  X                                    |             
      Clear Cell Focus                     |                                  X  X                                    |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                    2                     |             
      Eosinophilic Focus                   | X                                                                        |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  | 2        2                                         2                     |             
      Hepatodiaphragmatic Nodule           | X                       X                          X                     |             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     1           2  1        2  2     3     2  2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Fat, Necrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Acinus, Atrophy                      |                1     2  2           1           1  2                     |             
      Acinus, Basophilic Focus             |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                         +                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Acanthosis                           |          2                                                               |             
      Hyperkeratosis                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Mineralization                       |                      1                                      2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Cardiomyopathy                       | 2  2     2     2     2  2  1  2  2        2     2        2  2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Hyperplasia                          |                                  1        2     2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     M     M  +  +  M  +  +     +     +  +     +  +            |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Pars Distalis, Angiectasis           | 3                       2     2                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                            1                             1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      C-Cell, Hyperplasia                  |          1                                                               |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Inflammation, Chronic Active         |          3           2  2  1                             2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
      Epithelium, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Interstitial Cell, Hyperplasia       |          1     2        1     1                          1  1            |             
      Seminiferous Tubule, Atrophy         | 2        3           4  3           2              4     3  2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Histiocyte    |          2           2  1  1                             2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                               3  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     M     M  M  +  +  +  +     +     +  +     +  +            |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +     M     +  +  +  +  M  M     +     M  +     M  M            |             
      Galactocele                          |    X                                                                     |             
      Acinus, Hyperplasia                  |          2           2  2  1                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  M            |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Fibrosis                             |                                                 2                        |             
      Infiltration Cellular, Histiocyte    |                      1  1  1                             1               |             
      Inflammation, Acute                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Fungus                               |                               2                                          |             
      Inflammation, Acute                  |                3           2  2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +  +                     |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +  +                     |             
      Hemorrhage                           |                                                 2                        |             
      Lens, Cataract                       |                                                 2                        |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 3  3     3     2     3  2  1  3  3  3     2     3  2     2  3            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Diverticulum                         |                                                                          |      1  3.0|
      Parasite                             |                               2                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
      Parasite                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  M  +  +        +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Angiectasis, Focal                   |                                                    3                     |      1  3.0|
      Angiectasis                          |                                  2  1                                    |      4  1.5|
      Basophilic Focus                     |    X  X        X                 X  X  X           X  X                  |     17  1.0|
      Clear Cell Focus                     |       X                                X                                 |      6     |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Eosinophilic Focus                   |    X                             X                 X                     |      5     |
      Fatty Change, Diffuse                |             3           3                                                |      3  2.7|
      Fatty Change, Focal                  |                                  2                                       |      9  2.0|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      7     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      3  2.0|
      Bile Duct, Hyperplasia               | 2  2  2  2     2     2  2        2  3  2              1  1               |     34  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Fat, Necrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Acinus, Atrophy                      |          2           1  1           2                 1                  |     22  1.7|
      Acinus, Basophilic Focus             |                X              X                       X                  |      5     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Acanthosis                           |                         2                                                |      2  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Mineralization                       |                                                       1                  |      3  1.3|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Cardiomyopathy                       | 2     2  2     2  2  2  2     2        2           2  2  1               |     33  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Hyperplasia                          | 2                 2              1                    2  2               |     12  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  M  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +     +  +  +  +  +        M  +  M               |  45        |
      Pars Distalis, Angiectasis           |                2                       3                                 |      8  2.3|
      Pars Distalis, Cyst                  |                      X                                                   |      1     |
      Pars Distalis, Hyperplasia           |    2           2                 2  2     2                              |      8  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      C-Cell, Hyperplasia                  |                                                                          |      4  1.8|
      Follicle, Cyst                       |                                                    X                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        M  +  +               |  48        |
      Inflammation, Chronic Active         |             1           1              3                                 |     11  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Epithelium, Hyperplasia              |                   2                       3                              |      4  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1  2     1        1     1              1  2           1                  |     20  1.4|
      Seminiferous Tubule, Atrophy         | 2  2  2  2        2  2  3     2  2  2  2  2        2                     |     34  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M  +               |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                         2                             2  2               |     10  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Fibrosis                             |       2           3           2                                          |      4  2.5|
      Hematopoietic Cell Proliferation     | 2     2  2     2              2  2     2           2  3  4               |     20  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  M  +  M  +  +     +  +  M  M  +        +  +  +               |  41        |
      Epithelial Cell, Hyperplasia         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  M  M  +  +     +  M  +  M  M        +  M  M               |  28        |
      Galactocele                          |                                                                          |      2     |
      Acinus, Hyperplasia                  |             2           1                                                |      7  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  48        |
      Acanthosis                           |                                                    2                     |      1  2.0|
      Cyst Epithelial Inclusion            |       X                                                                  |      2     |
      Hyperkeratosis                       |       3                                                                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Hemorrhage                           |             4                                                            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Fibrosis                             |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                       1                  |      6  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  47        |
      Fungus                               |                                                                          |      2  2.0|
      Inflammation, Acute                  |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +  +     +                                                            |   6        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                               +                     |   6        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Lens, Cataract                       |    3                                               2                     |      4  2.3|
      Retina, Atrophy                      |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Cyst                                 |                                     X              X                     |      3     |
      Nephropathy                          | 2  3  3  2  2  2  2  3  2     1  3  3  3  3        4  3  2               |     49  2.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Calculus Micro Observation Only      |                                                       2  X               |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  M  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +        +  +  M  +     +  +  M  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X        X           X     X              X              X         |             
      Clear Cell Focus                     |                X                                               X         |             
      Degeneration, Cystic                 |                                              2                           |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Focal                  |          2                                            3              1  3|             
      Hepatodiaphragmatic Nodule           |       X        X                                                         |             
      Hyperplasia, Focal                   |                                                                          |             
      Mixed Cell Focus                     |                                              X                           |             
      Necrosis                             |             1                                                  3  2      |             
      Thrombosis                           |                                     4                                    |             
      Bile Duct, Hyperplasia               |       1  2  2  2  2        2        2     2     2  2           2     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +  +               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Acinus, Atrophy                      |             2              2  2     2     1  1  2        2           2   |             
      Acinus, Basophilic Focus             |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Acanthosis                           |          1                                         2                     |             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy                       |       2  2  3  2  2        2  2  2  2     1  2  2  1           2  3     3|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +  +        +  +  +  +     +  +  +  M  +  +     +  +  +  +|             
      Hyperplasia                          |                2                                                  2  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  M  +        +  +  +  +     +  +  +  M  +  M     +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |                2  3        2                                      2      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          3  2                             1        2              2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  1                       1                                    |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |          4  2                       2                 2                  |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  +|             
      Epithelium, Hyperplasia              |          1                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Interstitial Cell, Hyperplasia       |       2  1     1  2        1                 1  1     1  1     2  1  2   |             
      Seminiferous Tubule, Atrophy         |       2  3  3  2  2        2  2     4        3  3  3           2  2  2  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +        +  +  +  +     +  M  +  +  +  +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          1  2                                            2               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Fibrosis                             |                                              2                       2   |             
      Hematopoietic Cell Proliferation     |       2                    3     2           3                 2  3      |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  M  +        +  M  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  M  M        M  M  M  +     +  +  M  M  +  +     M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |                                                                          |             
      Acinus, Hyperplasia                  |          1                          3                 2  2              3|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                    +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Histiocyte    |          1                          1        2                           |             
      Metaplasia, Osseous                  |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |       2  3  2  3  2        2  2  2  2     2  2  2  2     1     3  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Basophilic Focus                     |    X                 X        X     X           X        X     X  X      |             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Cystic                 | 1                                                                        |             
      Eosinophilic Focus                   | X                                                        X               |             
      Fatty Change, Focal                  |          1                          1                    2               |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Hyperplasia, Focal                   |                                                                      2   |             
      Mixed Cell Focus                     |                                     X                    X               |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     2              3     2     2  1        2        2     2  2  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Acinus, Atrophy                      | 2        2     1        1                       2              2         |             
      Acinus, Basophilic Focus             |                                                                X         |             
      Acinus, Hyperplasia                  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |          2                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Cardiomyopathy                       | 2  2     2  2  3     2        2     2           2        3     2  2  2  2|             
      Thrombosis                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Hyperplasia                          |          2              2           1           2              2        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Hyperplasia                          | 2                                                              2        2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +     +  M     +     M  +        +        +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Pars Distalis, Angiectasis           |             3  2        3                                                |             
      Pars Distalis, Cyst                  | X                                                                        |             
      Pars Distalis, Hyperplasia           | 2  2           2                                         2     2        2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  1        1                                   2                    1   |             
      Follicular Cell, Hyperplasia         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Interstitial Cell, Hyperplasia       |             2        2              1  1        1              1     2   |             
      Seminiferous Tubule, Atrophy         |                2     2        3     2           3              2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Renal, Pigmentation                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +     +     +  +        M        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  M     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     +  M  M     M  M     +     +  +        M        M     M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |                               X                                          |             
      Acinus, Hyperplasia                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Hyperkeratosis                       | 3        3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1                                                                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                2                                                  3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
      Lens, Cataract                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2     3  3  2     3  2     3     3  2        3        3     2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +        M  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X  X           X  X                 X        X     X                     |     21     |
      Clear Cell Focus                     |                      X           X                                       |      5     |
      Degeneration, Cystic                 |                                              2                           |      3  1.7|
      Eosinophilic Focus                   |                                                                          |      2     |
      Fatty Change, Focal                  |                                                    1                     |      8  1.8|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      4     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                                                                          |      3  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               | 2  2  2        2  2  2           2  2  2        2  2  2                  |     36  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Acinus, Atrophy                      |    2  2                 2                       2     3  2               |     21  1.9|
      Acinus, Basophilic Focus             |                                                                          |      1     |
      Acinus, Hyperplasia                  |                2                       2                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +        +  +  +     +  +  +  M  +               |  48        |
      Acanthosis                           |                                                                          |      2  1.5|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Necrosis                             |                                        3                 4               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Hyperplasia                          |    1                                                                     |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 2  2  2        2  2  2  2        2     2        2  2     1               |     42  2.0|
      Thrombosis                           |                                     2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Hyperplasia                          |       1                 2        2  1           2  2  2                  |     16  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +        +  +  +     +  +  M  +  +               |  47        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  M               |  49        |
      Pars Distalis, Angiectasis           |                2        2              3        3                        |     11  2.5|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                    2  2                  |     13  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      C-Cell, Hyperplasia                  |                                  1                                       |      9  1.2|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Inflammation, Chronic Active         |                                                          4               |      6  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Interstitial Cell, Hyperplasia       | 2  1              2     1        1  2  2           2                     |     27  1.4|
      Seminiferous Tubule, Atrophy         |    2           2  2     2        2  2  2        3  2                     |     31  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        M  +  +  +        +  +  +     +  +  +  +  +               |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |    2              2              2  2        2        2                  |     12  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +  +        M  M  +     M  +  +  +  M               |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M        M  M  +  M        M  M  +     +  M  +  +  M               |  18        |
      Galactocele                          |                                        X                                 |      2     |
      Acinus, Hyperplasia                  |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Hyperkeratosis                       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Infiltration Cellular, Histiocyte    |                      1                             2                     |      6  1.3|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                      2                 2     2                           |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Fungus                               |                                                 2                        |      1  2.0|
      Inflammation, Acute                  |    2                                                  2                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                    +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +  +                 +                                 |   6        |
      Lens, Cataract                       |                   2  2                 3                                 |      4  2.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Cyst                                 |                X                             X                           |      2     |
      Nephropathy                          | 3  2  2        3  2  3  2        3  2  3     3  3  3  2  2               |     49  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  M  M        +  +  +     M  +     +   |             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Angiectasis, Focal                   | 3                                                                        |             
      Angiectasis                          |          1                                            2                  |             
      Basophilic Focus                     | X     X  X     X                 X                    X                  |             
      Clear Cell Focus                     |       X  X                                                  X            |             
      Degeneration, Cystic                 | 1           2                                                            |             
      Eosinophilic Focus                   | X              X                 X                                       |             
      Fatty Change, Diffuse                |                                                                      2   |             
      Fatty Change, Focal                  |                                     2                                    |             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Mixed Cell Focus                     |                X                                                         |             
      Necrosis                             |                            2                                             |             
      Bile Duct, Hyperplasia               | 2     2     2  2              2  2  2  3        3  2  2     2        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
      Acinus, Atrophy                      | 2           2  2     3                                2                  |             
      Acinus, Basophilic Focus             |                                                             X            |             
      Acinus, Hyperplasia                  |       2                       1                                          |             
      Artery, Fibrosis                     |                      2                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Hyperkeratosis                       |                                                    3                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Cardiomyopathy                       | 2     2  3  2  2     2     2  2  2     2                    2  2     2   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Hyperplasia                          |          2  2  2                                2  1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Pars Distalis, Angiectasis           |                2                    2                 4        2     3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2  2  2                       2                          2         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      C-Cell, Hyperplasia                  |             2        2        2     1                                    |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Granuloma Sperm                      | 3                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +     +  +  +  M  +        +  +  +     M  +     +   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Interstitial Cell, Hyperplasia       | 2     2  1  2                 1     1           2     1     2  2     2   |             
      Seminiferous Tubule, Atrophy         | 3     2  2  3              2  2  3  3           2           2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Mediastinal, Fibrosis                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     M  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M     +  +  M  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Fibrosis                             |                                     2           2  2                     |             
      Hematopoietic Cell Proliferation     |          2     2     2        2  2  2              2        2        2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     M     M  M  +  +  M        +  +  +     M  M     +   |             
      Galactocele                          |                X                                                         |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Hyperkeratosis                       |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Fibrosis                             |                                                             2            |             
      Infiltration Cellular, Histiocyte    |                                     2                                    |             
      Inflammation, Acute                  |                1                                                         |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +                 +  +                  |             
      Lens, Cataract                       |                      2                             3  2                  |             
      Retina, Atrophy                      |                                  2                 3                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 3     3  2  2  3     4        2  3  2  2        3  2  2     3  3     3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                              2           2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                   2      |             
      Basophilic Focus                     | X     X                 X  X                                X  X         |             
      Clear Cell Focus                     |                      X                       X     X           X         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   | X                                                                        |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                                      X     X                           |             
      Hyperplasia, Focal                   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                           1        3                     |             
      Bile Duct, Hyperplasia               | 2     2              3  2  2        2  2     2     2  2  2  2  3  3  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       M                                                                  |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1     2           2  2                       2  2  2  1  1  1  1  1  1   |             
      Acinus, Basophilic Focus             |                                     X                    X               |             
      Acinus, Hyperplasia                  |                                     2                          2         |             
      Artery, Fibrosis                     |                                                             2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2           2        2        2     2  2     2        2     2     1|             
      Thrombosis                           | 2                                                  3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2  2                 2  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +           +  +  M  +        +  +  +  M  M  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2                 2  2                       3        4|             
      Pars Distalis, Cyst                  |                                                             X            |             
      Pars Distalis, Hyperplasia           |                   2        2        2        2  2                        |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                          1               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   3     1|             
                                            __________________________________________________________________________|             
   Prostate                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Epithelium, Hyperplasia              |                                           1                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |       2                 1  1        2  1  2  2           2     2  2      |             
      Seminiferous Tubule, Atrophy         |       2                 2  2        3  2                 2     3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Fibrosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +  +  +  +        +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                2         |             
      Hematopoietic Cell Proliferation     | 2                    2  2  2                 2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           +  +  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M           M  +  M  M        M  M  M  +  M  +  +  M  +  +  +  +  +|             
      Galactocele                          |                                                                X         |             
      Acinus, Hyperplasia                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    | M     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Hyperkeratosis                       |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                                                                  |             
      Inflammation, Acute                  |                                                                          |             
      Metaplasia, Osseous                  | 1                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                   2      |             
      Inflammation, Acute                  |                            1                                      2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     | +                          +                                            +|             
      Lens, Cataract                       | 2                          2                                             |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 | X                                   X                                    |             
      Hydronephrosis                       |                                     2                                    |             
      Nephropathy                          | 3     3           2  2  2  2        3  2  2  2  2  3  2  3  3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                X         |             
      Calculus Micro Observation Only      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  45        |
      Parasite                             |          1           2              1                                    |      5  1.6|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
      Parasite                             |                                        1                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Angiectasis                          |                      2                                                   |      4  1.8|
      Basophilic Focus                     | X              X     X                       X                           |     16     |
      Clear Cell Focus                     |                X              X              X                           |     10     |
      Degeneration, Cystic                 |                                  1                       1               |      4  1.3|
      Eosinophilic Focus                   |                      X           X                                       |      6     |
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                         3              1                                 |      3  2.0|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      5     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      3  2.0|
      Bile Duct, Hyperplasia               | 2  2     1     2     2  2     2  2  2  2     2           3               |     41  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             M                          +                                 |   1        |
      Fat, Inflammation, Chronic Active    |                                        3                                 |      1  3.0|
      Fat, Necrosis                        |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Acinus, Atrophy                      |                      2  2     2  2                       3               |     23  1.8|
      Acinus, Basophilic Focus             |                                                                          |      3     |
      Acinus, Hyperplasia                  |                                  2                                       |      5  1.8|
      Artery, Fibrosis                     | 2                    3                                                   |      4  2.3|
      Artery, Inflammation, Chronic Active | 1                    2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Necrosis                             |                         4                                                |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
      Mineralization                       |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Cardiomyopathy                       | 2  2     2     2     2  2     2  2     2     2                           |     34  2.0|
      Thrombosis                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Hyperplasia                          |                                  2     2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Hyperplasia                          |                               2  2  2  1     3                           |     14  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  M        M  +     M  +  +  M     +           +               |  37        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Pars Distalis, Angiectasis           |                                                                          |     10  2.6|
      Pars Distalis, Cyst                  |    1                    X                                                |      3  1.0|
      Pars Distalis, Hyperplasia           | 2  3        2        2  3     2     2        2                           |     18  2.1|
      Pars Intermedia, Cyst                |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      C-Cell, Hyperplasia                  |                      1                                                   |      6  1.5|
      Follicular Cell, Hyperplasia         |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Inflammation, Chronic Active         |             1           1                                                |      5  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  46        |
      Epithelium, Hyperplasia              |                                              2                           |      2  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1  2     1  2                 1  2  2                    2               |     29  1.7|
      Seminiferous Tubule, Atrophy         | 2                       3     2                          3               |     21  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Mediastinal, Fibrosis                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M     +  +  +     +  +     +  +  +  +     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
      Infiltration Cellular, Histiocyte    |    2     1  2           2           1  1                                 |      7  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
      Fibrosis                             |                               2                                          |      5  2.0|
      Hematopoietic Cell Proliferation     | 2  4           2     2        2  3           2                           |     25  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +     +  +     +  +  M  +     +           +               |  47        |
      Cyst                                 |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     +  +  M     M  M     M  +  M  +     +           +               |  26        |
      Galactocele                          |                                                                          |      2     |
      Acinus, Hyperplasia                  |    1     2  1                          2                                 |      5  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +     +  +     +  +  +  +     M           +               |  47        |
      Acanthosis                           |                         2                                                |      1  2.0|
      Cyst Epithelial Inclusion            |                               X                                          |      3     |
      Hyperkeratosis                       |                         4     4                                          |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Hemorrhage                           |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Fibrosis                             |                                     2                                    |      2  2.0|
      Infiltration Cellular, Histiocyte    |    1                                2  1                                 |      5  1.4|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05057-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/25/97  
Route: DOSED FEED                                                                                                 Time: 16:37:44  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                       +     +  +           +                           |  12        |
      Lens, Cataract                       | 2                                                                        |      6  2.2|
      Retina, Atrophy                      |                                  2                                       |      3  2.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +  +           +                           |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Cyst                                 |                               X                                          |      4     |
      Hydronephrosis                       |             4                                                            |      2  3.0|
      Nephropathy                          | 3  2     1     3     3  3     3  1  2  1     3           2               |     47  2.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------