National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2399

TDMS Study 05058-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             ROXARSONE


NTP Experiment-Test: 05058-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: DOSED FEED                                                                                                 Time: 08:58:55




       Facility:  Southern Research Institute

       Chemical CAS #:  121-19-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     14           15           12                                                  
    Moribund Sacrifice                                21           17           21                                                  
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           18           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (45)         (47)                                                
      Epithelium, Degeneration, Hyaline                                          1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Serosa, Inflammation, Suppurative                                          1 (2%)                                             
   Intestine Large, Cecum                             (48)         (49)         (46)                                                
      Edema                                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (50)         (46)                                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (50)         (46)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Perforation                                                   1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                10 (20%)     20 (40%)     18 (36%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Infarct                                          1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear        21 (42%)     24 (48%)     20 (40%)                                            
      Inflammation, Focal                                           1 (2%)       1 (2%)                                             
      Necrosis, Focal                                               3 (6%)       1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)                                                          
      Bile Duct, Degeneration, Hyaline                                           1 (2%)                                             
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)                                                                       
      Serosa, Inflammation, Suppurative                             3 (6%)                                                          
   Mesentery                                          (27)         (27)         (30)                                                
      Inflammation, Suppurative                       23 (85%)     25 (93%)     29 (97%)                                            
      Fat, Necrosis                                    2 (7%)       1 (4%)       1 (3%)                                             
   Pancreas                                           (50)         (50)         (49)                                                
      Atrophy, Focal                                                             2 (4%)                                             
      Edema                                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Hyperplasia, Cystic                                                  1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (49)                                                
      Hyperplasia, Papillary                           1 (2%)       6 (12%)                                                         
      Inflammation, Diffuse, Suppurative               1 (2%)                                                                       
      Inflammation, Focal                                           3 (6%)                                                          
      Ulcer                                                                      1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (49)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Abdominal, Thrombosis                                                      1 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Suppurative                        1 (2%)       2 (4%)       1 (2%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Artery, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       2 (4%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Capsule, Inflammation, Suppurative                            1 (2%)       1 (2%)                                             
      Corticomedullary Junction, Degeneration,                                                                                      
           Fatty                                       1 (2%)                                                                       
      Extra Adrenal Tissue, Inflammation,                                                                                           
          Suppurative                                  4 (8%)       2 (4%)                                                          
      Subcapsular, Hyperplasia, Focal                                            1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Developmental Malformation                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)                                                          
   Parathyroid Gland                                  (46)         (44)         (47)                                                
      Cyst                                                          1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (46)         (49)                                                
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                7 (14%)      5 (11%)      1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Cyst                                             1 (2%)       2 (4%)                                                          
      Degeneration, Cystic                             5 (10%)      2 (4%)       8 (16%)                                            
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                     2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Bacterium                                        1 (100%)                                                                     
      Hyperplasia, Neutrophil                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                  (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
   Ovary                                              (49)         (49)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Granuloma                                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Inflammation, Suppurative                       25 (51%)     29 (59%)     29 (58%)                                            
      Follicle, Cyst                                  10 (20%)     18 (37%)     17 (34%)                                            
   Oviduct                                            (7)          (3)          (3)                                                 
      Dilatation                                       1 (14%)                                                                      
      Inflammation, Suppurative                        6 (86%)      3 (100%)     3 (100%)                                           
   Uterus                                             (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Hydrometra                                       1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                       21 (42%)     33 (66%)     23 (46%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                46 (92%)     49 (98%)     48 (96%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Angiectasis                                      3 (6%)                    1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Bronchial, Bacterium                             1 (2%)                                                                       
      Bronchial, Hyperplasia                           1 (2%)                    3 (6%)                                             
      Bronchial, Inflammation, Suppurative             1 (2%)                    3 (6%)                                             
      Bronchial, Mediastinal, Hyperplasia                           1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Iliac, Hyperplasia                               1 (2%)       4 (8%)       8 (16%)                                            
      Iliac, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Iliac, Inflammation, Suppurative                                           1 (2%)                                             
      Inguinal, Hyperplasia                                         1 (2%)                                                          
      Inguinal, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Lumbar, Hyperplasia                                           1 (2%)       3 (6%)                                             
      Mediastinal, Cyst                                1 (2%)                                                                       
      Mediastinal, Hyperplasia                         6 (12%)      7 (14%)      7 (14%)                                            
      Mediastinal, Inflammation, Suppurative           4 (8%)                    5 (10%)                                            
      Pancreatic, Hyperplasia                                                    1 (2%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Renal, Angiectasis                                                         1 (2%)                                             
      Renal, Hyperplasia                              13 (26%)     14 (28%)     16 (32%)                                            
      Renal, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Renal, Inflammation, Suppurative                              1 (2%)       1 (2%)                                             
      Renal, Mediastinal, Hyperplasia                               1 (2%)                                                          
   Lymph Node, Mandibular                             (40)         (48)         (42)                                                
      Hyperplasia                                      1 (3%)                    3 (7%)                                             
      Hyperplasia, Lymphoid                            3 (8%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (48)         (46)                                                
      Angiectasis                                      5 (10%)      6 (13%)     10 (22%)                                            
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
      Hyperplasia                                      3 (6%)       4 (8%)       3 (7%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                29 (58%)     30 (60%)     31 (63%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       2 (4%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Red Pulp, Depletion Cellular                                  1 (2%)                                                          
   Thymus                                             (39)         (42)         (44)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Duct, Dilatation                                 2 (4%)       7 (14%)     10 (20%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Inflammation, Chronic                            2 (4%)       2 (4%)       3 (6%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosis                                 1 (2%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (6)          (2)          (2)                                                 
      Inflammation, Suppurative                        3 (50%)      2 (100%)     2 (100%)                                           
      Adventitia, Inflammation, Focal                  1 (17%)      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Compression                                                   1 (2%)       3 (6%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Mineralization                                  26 (52%)     25 (51%)     19 (38%)                                            
      Meninges, Inflammation, Chronic                               1 (2%)                                                          
      Ventricle, Mineralization, Focal                                           1 (2%)                                             
   Peripheral Nerve                                   (50)         (50)         (50)                                                
      Sciatic, Hyperplasia, Lymphoid                                             1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Meninges, Hyperplasia, Lymphoid                  4 (8%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                    19 (38%)     23 (46%)     13 (26%)                                            
      Congestion                                       6 (12%)      2 (4%)       2 (4%)                                             
      Hemorrhage, Focal                                1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            4 (8%)       4 (8%)       1 (2%)                                             
      Hyperplasia, Macrophage                          1 (2%)       3 (6%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear        17 (34%)     14 (28%)     15 (30%)                                            
      Inflammation, Focal                             18 (36%)     21 (42%)     12 (24%)                                            
      Inflammation, Suppurative                        1 (2%)       4 (8%)       4 (8%)                                             
      Mineralization                                   2 (4%)                                                                       
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          3 (6%)       4 (8%)       1 (2%)                                             
      Alveolar Epithelium, Metaplasia, Focal           2 (4%)       2 (4%)       1 (2%)                                             
      Mediastinum, Inflammation, Suppurative           8 (16%)      7 (14%)      7 (14%)                                            
   Nose                                               (48)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Lumen, Exudate                                                4 (8%)                                                          
      Lumen, Foreign Body                                           2 (4%)                                                          
      Mucosa, Inflammation, Suppurative                             2 (4%)                                                          
      Nasolacrimal Duct, Inflammation                                            1 (2%)                                             
   Trachea                                            (49)         (50)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Dilatation                                                         1 (2%)                                             
      Glands, Exudate                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (3)                                                 
      Foreign Body                                                               1 (33%)                                            
      Hyperplasia, Focal                               1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Lymphoid                            7 (14%)      1 (2%)       1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         6 (12%)      2 (4%)       1 (2%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)       4 (8%)       1 (2%)                                             
      Inflammation, Multifocal                                                   2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
      Mineralization                                   1 (2%)       4 (8%)       1 (2%)                                             
      Nephropathy                                      7 (14%)      4 (8%)       3 (6%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Capsule, Inflammation, Suppurative               3 (6%)      12 (24%)      5 (10%)                                            
      Glomerulus, Inflammation                                                   3 (6%)                                             
      Papilla, Necrosis                                             1 (2%)       1 (2%)                                             
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)                                                          
   Urethra                                                                      (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
      Mineralization                                                             1 (100%)                                           
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17            9           11                                                  
    Natural Death                                      6            1            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           40           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (42)         (48)                                                
      Hyperplasia, Papillary                                                     1 (2%)                                             
   Intestine Large, Rectum                            (47)         (49)         (46)                                                
      Dysplasia                                                     2 (4%)                                                          
      Inflammation, Chronic                                         2 (4%)                                                          
      Prolapse                                                      2 (4%)                                                          
      Ulcer                                                         2 (4%)                                                          
   Intestine Small, Duodenum                          (49)         (45)         (47)                                                
      Submucosa, Degeneration, Focal                                             1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (49)         (48)                                                
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                    2 (4%)                                             
      Atrophy                                                       1 (2%)                                                          
      Basophilic Focus                                 1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Cyst Multilocular                                                          1 (2%)                                             
      Developmental Malformation                       1 (2%)                                                                       
      Eosinophilic Focus                                                         1 (2%)                                             
      Fibrosis, Focal                                  2 (4%)       2 (4%)                                                          
      Focal Cellular Change                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Focal                                                        2 (4%)                                             
      Mineralization, Focal                            1 (2%)       2 (4%)                                                          
      Necrosis, Focal                                  2 (4%)       2 (4%)       1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)       1 (2%)                                                          
      Nuclear Alteration                               1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Bile Duct, Dilatation                                         2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                                        2 (4%)                                                          
      Centrilobular, Necrosis                          1 (2%)                    1 (2%)                                             
   Mesentery                                          (4)          (4)          (6)                                                 
      Hemorrhage                                       1 (25%)                                                                      
      Hyperplasia, Lymphoid                                         1 (25%)                                                         
      Inflammation, Suppurative                                     1 (25%)      1 (17%)                                            
      Fat, Necrosis                                                 2 (50%)      4 (67%)                                            
   Pancreas                                           (49)         (50)         (50)                                                
      Accessory Spleen                                                           1 (2%)                                             
      Atrophy, Focal                                   1 (2%)                                                                       
      Edema                                            1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperplasia, Papillary                           1 (2%)       2 (4%)                                                          
      Inflammation, Focal                              1 (2%)       3 (6%)                                                          
      Pigmentation, Focal                                                        1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Degeneration, Hyaline                                         1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)                                             
   Tooth                                              (14)         (8)          (7)                                                 
      Incisor, Dysplasia                              12 (86%)      8 (100%)     4 (57%)                                            
      Incisor, Inflammation, Suppurative               8 (57%)      2 (25%)      5 (71%)                                            
      Molar, Inflammation, Suppurative                                           1 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (1)                                                 
      Abdominal, Inflammation, Chronic                                           1 (100%)                                           
      Mesenteric Artery, Inflammation, Chronic         1 (100%)                                                                     
   Heart                                              (50)         (50)         (50)                                                
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Focal                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 2 (4%)                                                                       
      Subcapsular, Hyperplasia, Focal                               2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (49)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
   Parathyroid Gland                                  (47)         (44)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                             3 (6%)                    2 (4%)                                             
      Cyst, Multiple                                                1 (2%)                                                          
      Degeneration, Cystic                             1 (2%)                                                                       
   Pituitary Gland                                    (45)         (46)         (45)                                                
      Cyst                                             1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Pars Distalis, Cytoplasmic Alteration, Focal                  1 (2%)                                                          
      Pars Intermedia, Cytomegaly                      1 (2%)                                                                       
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Degeneration, Cystic                             5 (10%)     10 (21%)     11 (22%)                                            
      Inflammation, Focal                                           1 (2%)       1 (2%)                                             
      Pigmentation                                                               2 (4%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (2)                                                                           
      Serosa, Foreign Body                             1 (50%)                                                                      
      Serosa, Inflammation, Chronic                    1 (50%)                                                                      
   Penis                                              (1)          (2)          (1)                                                 
      Foreign Body                                     1 (100%)                                                                     
      Inflammation, Chronic                            1 (100%)                  1 (100%)                                           
      Necrosis                                         1 (100%)                                                                     
   Preputial Gland                                    (11)         (13)         (7)                                                 
      Degeneration, Cystic                             4 (36%)      8 (62%)      5 (71%)                                            
      Inflammation, Suppurative                        8 (73%)      8 (62%)      4 (57%)                                            
   Prostate                                           (50)         (50)         (49)                                                
      Inflammation, Suppurative                        3 (6%)                    1 (2%)                                             
   Seminal Vesicle                                    (2)          (3)          (2)                                                 
      Atrophy                                                       1 (33%)                                                         
      Dilatation                                       1 (50%)      1 (33%)                                                         
      Fibrosis, Focal                                  1 (50%)                                                                      
      Lumen, Crystals                                               1 (33%)                                                         
   Testes                                             (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Artery, Mineralization                                        2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hyperplasia, Neutrophil                          1 (2%)                                                                       
   Lymph Node                                         (50)         (49)         (50)                                                
      Axillary, Hyperplasia                                                      1 (2%)                                             
      Axillary, Inflammation, Suppurative              1 (2%)                                                                       
      Inguinal, Angiectasis                                                      2 (4%)                                             
      Inguinal, Hyperplasia                            6 (12%)      2 (4%)       3 (6%)                                             
      Inguinal, Hyperplasia, Lymphoid                               1 (2%)                                                          
      Inguinal, Inflammation, Chronic                  2 (4%)                                                                       
      Inguinal, Pigmentation                                        1 (2%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (42)         (43)                                                
      Hyperplasia                                                                1 (2%)                                             
   Lymph Node, Mesenteric                             (43)         (48)         (47)                                                
      Angiectasis                                      8 (19%)     11 (23%)     11 (23%)                                            
      Hematopoietic Cell Proliferation                 2 (5%)                                                                       
      Pigmentation                                                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Depletion Lymphoid                                            1 (2%)                                                          
      Hematopoietic Cell Proliferation                16 (32%)     12 (24%)     12 (24%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Red Pulp, Depletion Cellular                     1 (2%)       1 (2%)                                                          
   Thymus                                             (36)         (40)         (43)                                                
      Cyst                                             2 (6%)                                                                       
      Depletion Lymphoid                                            1 (3%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Exudate                                          2 (4%)                                                                       
      Fibrosis                                         1 (2%)       2 (4%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Chronic                           19 (38%)     28 (56%)     15 (30%)                                            
      Mineralization                                   1 (2%)       2 (4%)                                                          
      Ulcer                                           13 (26%)      6 (12%)      3 (6%)                                             
      Ulcer, Multiple                                  1 (2%)                                                                       
      Lip, Inflammation, Suppurative                                1 (2%)                                                          
      Prepuce, Inflammation, Chronic                   1 (2%)                                                                       
      Subcutaneous Tissue, Angiectasis                              1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Edema                       2 (4%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (2%)                                             
      Subcutaneous Tissue, Inflammation,                                                                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Suppurative                                  2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Mineralization                                        1 (2%)                                             
      Subcutaneous Tissue, Ulcer                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)          (2)                                                 
      Artery, Head, Inflammation, Chronic              1 (100%)                                                                     
      Thigh, Mineralization                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Mineralization                                  25 (50%)     31 (62%)     26 (52%)                                            
      Artery, Meninges, Inflammation, Chronic          1 (2%)                                                                       
      Meninges, Hyperplasia, Lymphoid                                            1 (2%)                                             
   Peripheral Nerve                                   (50)         (50)         (50)                                                
      Sciatic, Hyperplasia, Lymphoid                   2 (4%)       1 (2%)                                                          
   Spinal Cord                                        (50)         (50)         (50)                                                
      Meninges, Hyperplasia, Lymphoid                               1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                    14 (28%)     28 (56%)     24 (48%)                                            
      Congestion                                       1 (2%)                    2 (4%)                                             
      Hemorrhage, Focal                                1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Macrophage                          3 (6%)       3 (6%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear         4 (8%)       2 (4%)       5 (10%)                                            
      Inflammation, Focal                             21 (42%)     31 (62%)     25 (50%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pigmentation                                     2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          5 (10%)      3 (6%)       2 (4%)                                             
      Alveolar Epithelium, Metaplasia, Focal           4 (8%)       4 (8%)       3 (6%)                                             
   Nose                                               (48)         (49)         (48)                                                
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Adventitia, Inflammation, Focal                  1 (2%)                    1 (2%)                                             
      Adventitia, Inflammation, Suppurative                         1 (2%)                                                          
      Lumen, Exudate                                   4 (8%)      17 (35%)      2 (4%)                                             
      Lumen, Foreign Body                              1 (2%)      13 (27%)      1 (2%)                                             
      Mucosa, Inflammation, Suppurative                1 (2%)       1 (2%)       4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05058-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/12/94  
Route: DOSED FEED                                                                                                 Time: 08:58:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.01%        0.02%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Foreign Body                  1 (2%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation                               2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (6)          (4)                                                 
      Hyperplasia                                      1 (20%)                                                                      
      Hyperplasia, Focal                               2 (40%)                                                                      
      Duct, Dilatation, Focal                          1 (20%)      3 (50%)      1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Hyperplasia, Lymphoid                           13 (26%)     10 (20%)      2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Focal                              1 (2%)                                                                       
      Mineralization                                   7 (14%)      9 (18%)     17 (34%)                                            
      Nephropathy                                     19 (38%)     29 (58%)     25 (50%)                                            
      Pigmentation                                                  1 (2%)                                                          
      Artery, Inflammation, Chronic                    2 (4%)                                                                       
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                 1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (2%)                                             
   Urethra                                            (1)          (1)                                                              
      Bulbourethral Gland, Degeneration, Cystic                     1 (100%)                                                        
      Bulbourethral Gland, Fibrosis, Focal                          1 (100%)                                                        
      Bulbourethral Gland, Proliferation                                                                                            
          Connective Tissue                            1 (100%)                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.