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TDMS Study 05058-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/08/94   
EXP: 05058                        ROXARSONE                    TIME: 14:29:19   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C56508   
CONT: NOI-ES-28024                                             CAS: 121-19-7    
PATHOLOGIST: D. FARNELL                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/08/94  
EXP: 05058                        ROXARSONE                    TIME: 14:29:19  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C56508  
CONT: NOI-ES-28024                                             CAS: 121-19-7   
PATHOLOGIST: D. FARNELL                                                        

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      227   299   456   470   535   538   551   618   619   623                 |
 |      647   653   653   665   666   668   686   701   710   714                 |
 |      715   715   716                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.01%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      117   560   567   645   645   666   678   711   712   714                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.02%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      108   139   432   480   603   603   639   641   653   653                 |
 |      659   680   680   702   702   710   711                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0  98.0  96.0  96.0  92.0  88.0  86.0  72.0  54.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.01%      |   100.0  98.0  98.0  98.0  98.0  98.0  98.0  94.0  90.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.02%      |   100.0  96.0  96.0  96.0  96.0  92.0  92.0  88.0  78.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.01%            0.02%         |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%            80.0%            66.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.248N         P=0.009N         P=0.319N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       602.0            601.5            576.2         |
 |NATURAL DEATHS (C)      |       (27.5)           (56.6)           (45.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       670.6            703.5            677.0         |
 |(STANDARD ERROR)        |       (15.4)           (13.1)           (18.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 1    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      170   402   452   466   493   494   494   508   521   524                 |
 |      527   541   541   547   556   592   621   626   635   638                 |
 |      647   658   666   667   676   676   684   684   684   688                 |
 |      710   710   711   716   716                                               |
 |  CENSORED DEATHS                                                               |
 |      42                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.01%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      490   492   494   504   504   507   512   518   518   521                 |
 |      521   522   530   532   532   583   601   612   614   626                 |
 |      632   634   637   639   650   650   657   658   662   671                 |
 |      688   707                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.02%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      435   477   480   483   485   485   486   501   507   522                 |
 |      523   527   534   561   561   562   563   581   591   594                 |
 |      600   601   606   610   610   613   659   676   679   702                 |
 |      710   714   718                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0  98.0  98.0  98.0  95.9  91.8  73.5  67.3  55.1  28.6      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.01%      |   100.0 100.0 100.0 100.0 100.0 100.0  70.0  66.0  42.0  36.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.02%      |   100.0 100.0 100.0 100.0 100.0  88.0  74.0  56.0  46.0  34.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.01%            0.02%         |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       28.6%            36.0%            34.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000N         P=0.902N         P=1.000N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       589.7            581.8            574.4         |
 |NATURAL DEATHS (C)      |       (19.5)           (12.4)           (13.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       617.8            634.8            627.0         |
 |(STANDARD ERROR)        |       (20.1)           (12.8)           (13.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             ROXARSONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.01%            = 2
                                                        0.02%            = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                 32                1
      |
      |                   32  3             1          1                                        2
      |                       3                        1                    3    1              22
   95 +
      |                                                                     3    1 13            2            2
      |                                                                            13        1          3
      |
   90 +                                                                                                       2   2
      |
      |                                                                                      1 1        3    3    22
      |                                                                                        1          1        2    2
P  85 +
E     |                                                                                                      3 3
R     |
C     |
E  80 +                                                                                                   1   13 3      2   2
N     |
T     |                                                                                                       11 3  3
      |
S  75 +
U     |                                                                                                        1 1  3  3
R     |                                                                                                          11
V     |
I  70 +                                                                                                                33
V     |
A     |                                                                                                           1 1
L     |                                                                                                             1  13   3
   65 +
      |                                                                                                                11
      |
      |
   60 +                                                                                                                 11
      |
      |
      |
   55 +
      |                                                                                                                  1  1
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 2 obs hidden.

                                                             ROXARSONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.01%            = 2
                                                        0.02%            = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                           1                                        3       2
      |                             1                                   1    3      322
      |                                                                 1       1 1   22
      |                                                                           1 331
   90 +                                                                                22
      |                                                                                 22
      |                                                                              3131
      |                                                                                 12 1
P  80 +                                                                                    11
E     |                                                                                    31 1
R     |                                                                                    223   3
C     |                                                                                       111
E  70 +                                                                                     2   1   2 1
N     |                                                                                             2 12  1
T     |                                                                                          3 3  32 211
      |                                                                                                  2 11
S  60 +                                                                                               33   2111
U     |                                                                                                       11
R     |                                                                                                333  22 1  1
V     |                                                                                                      22
I  50 +                                                                                                           11
V     |                                                                                                  3    22 3 11
A     |                                                                                                        2 2 3
L     |                                                                                                          223   3
   40 +                                                                                                           2 11 31
      |                                                                                                              2 2
      |                                                                                                                233  2
      |                                                                                                                 11
   30 +
      |                                                                                                                  1  1
      |
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 23 obs hidden.

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