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https://ntp.niehs.nih.gov/go/2411

TDMS Study 05058-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             ROXARSONE


NTP Experiment-Test: 05058-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: DOSED FEED                                                                                                 Time: 07:31:04




       Facility:  Southern Research Institute

       Chemical CAS #:  121-19-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           12           16                                                  
    Natural Death                                      1            3            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           35           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (47)         (50)                                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (48)         (49)                                                
      Cyst                                                          1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       1 (2%)       2 (4%)                                             
   Intestine Large, Rectum                            (49)         (50)         (48)                                                
      Parasite Metazoan                                1 (2%)       3 (6%)       2 (4%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               1 (2%)       1 (2%)       4 (8%)                                             
      Basophilic Focus                                 2 (4%)       2 (4%)       4 (8%)                                             
      Basophilic Focus, Multiple                      23 (46%)     30 (60%)     27 (54%)                                            
      Clear Cell Focus                                 1 (2%)       1 (2%)       1 (2%)                                             
      Congestion                                                    1 (2%)                                                          
      Degeneration, Cystic                                          1 (2%)       1 (2%)                                             
      Degeneration, Fatty, Multifocal                  1 (2%)                                                                       
      Developmental Malformation                       6 (12%)      6 (12%)      8 (16%)                                            
      Eosinophilic Focus                               2 (4%)                                                                       
      Granuloma, Multifocal                           25 (50%)     29 (58%)     31 (62%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                                    3 (6%)       1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Mixed Cell Focus                                 3 (6%)                    1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)                    2 (4%)                                             
      Regeneration                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic, Diffuse                            4 (8%)       2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                              3 (6%)                                                          
      Biliary Tract, Proliferation                    17 (34%)     12 (24%)     16 (32%)                                            
      Centrilobular, Necrosis                         11 (22%)      9 (18%)      8 (16%)                                            
   Mesentery                                          (10)         (6)          (3)                                                 
      Cyst                                                          1 (17%)                                                         
      Mineralization, Multifocal                       1 (10%)                                                                      
      Fat, Necrosis, Focal                             8 (80%)      3 (50%)      3 (100%)                                           
      Fat, Necrosis, Multifocal                        1 (10%)                                                                      
   Pancreas                                           (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy, Focal                                  11 (22%)     11 (22%)     14 (28%)                                            
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
   Pharynx                                            (2)                       (1)                                                 
      Cyst                                             1 (50%)                                                                      
      Inflammation, Acute, Focal, Suppurative                                    1 (100%)                                           
   Salivary Glands                                    (50)         (47)         (48)                                                
      Atrophy, Focal                                   1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Erosion                                                                    1 (2%)                                             
      Hyperkeratosis                                                3 (6%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)       3 (6%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Edema                                                                      3 (6%)                                             
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic, Diffuse                                1 (2%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Tooth                                                           (2)          (1)                                                 
      Dysplasia                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  35 (70%)     30 (60%)     32 (64%)                                            
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Atrium, Thrombosis                                            1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Degeneration, Fatty, Focal                       6 (12%)      8 (16%)     13 (26%)                                            
      Degeneration, Fatty, Multifocal                                            4 (8%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Focal                                            1 (2%)       3 (6%)                                             
      Necrosis, Multifocal                                                       1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (48)         (50)                                                
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia, Focal                               2 (4%)                    1 (2%)                                             
      Necrosis, Multifocal                                                       1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (48)                                                
      Pars Distalis, Angiectasis                      28 (56%)     29 (59%)     24 (50%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                             11 (22%)      6 (12%)     10 (21%)                                            
      Pars Distalis, Hemorrhage                        1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                9 (18%)      6 (12%)     13 (27%)                                            
      Pars Distalis, Pigmentation, Hemosiderin         9 (18%)      1 (2%)       4 (8%)                                             
      Pars Distalis, Thrombosis                        1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Hyperplasia                              2 (4%)                                                                       
      C-Cell, Hyperplasia, Focal                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (47)         (48)                                                
      Abscess                                          2 (5%)                    1 (2%)                                             
      Hyperplasia                                      2 (5%)       7 (15%)      3 (6%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Duct, Cyst                                       4 (9%)       1 (2%)       5 (10%)                                            
      Duct, Hyperplasia                                                          1 (2%)                                             
   Ovary                                              (50)         (47)         (50)                                                
      Cyst                                             1 (2%)       2 (4%)       2 (4%)                                             
   Uterus                                             (50)         (49)         (50)                                                
      Cyst                                                                       2 (4%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hydrometra                                                                 3 (6%)                                             
      Hyperplasia, Cystic                                           1 (2%)       1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Cervix, Abscess                                  6 (12%)      6 (12%)      3 (6%)                                             
      Cervix, Abscess, Multiple                                                  1 (2%)                                             
      Cervix, Cyst                                     5 (10%)      7 (14%)      5 (10%)                                            
      Cervix, Cyst, Multiple                                        1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Ectasia                                                       1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (46)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      Ectasia                                          1 (2%)                    2 (4%)                                             
   Spleen                                             (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         2 (4%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)                                                
      Duct, Cyst                                      44 (88%)     47 (96%)     39 (78%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hypertrophy, Focal                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      7 (14%)      1 (2%)       1 (2%)                                             
      Hemorrhage, Multifocal                           2 (4%)       1 (2%)                                                          
      Lateral Ventricle, Dilatation                    1 (2%)                                                                       
   Peripheral Nerve                                   (50)         (47)         (50)                                                
      Infiltration Cellular, Mononuclear Cell                                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Fungus                                           1 (2%)                                                                       
      Granuloma, Multifocal                                                      1 (2%)                                             
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte                 1 (2%)       1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (2%)       4 (8%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     2 (4%)                                                                       
      Fungus                                           3 (6%)                    1 (2%)                                             
      Inflammation, Acute, Suppurative                 3 (6%)                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  1 (2%)       1 (2%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Erosion                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (20)         (5)                                                 
      Cataract                                         2 (67%)     19 (95%)      3 (60%)                                            
      Anterior Chamber, Fibrosis                                                 1 (20%)                                            
      Retina, Degeneration                             2 (67%)     20 (100%)     4 (80%)                                            
   Harderian Gland                                                              (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Fibrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Hydronephrosis                                                             1 (2%)                                             
      Nephropathy, Chronic                            36 (72%)     36 (72%)     28 (56%)                                            
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Degeneration, Multifocal                                     1 (2%)                                             
      Renal Tubule, Dilatation, Multifocal                                       1 (2%)                                             
   Urethra                                                                      (1)                                                 
      Calculus Gross Observation                                                 1 (100%)                                           
      Inflammation, Acute, Suppurative                                           1 (100%)                                           
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           25           27                                                  
    Natural Death                                      4            7            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           18           18                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (49)         (49)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Large, Colon                             (50)         (49)         (49)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Mineralization, Multifocal                       1 (2%)       2 (4%)       2 (4%)                                             
      Parasite Metazoan                                3 (6%)       1 (2%)                                                          
      Artery, Mineralization                           1 (2%)                                                                       
   Intestine Large, Rectum                            (48)         (50)         (49)                                                
      Mineralization, Multifocal                                                 1 (2%)                                             
      Parasite Metazoan                                3 (6%)       3 (6%)       3 (6%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)                                                
      Thrombosis                                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                              11 (22%)      4 (8%)       6 (12%)                                            
      Angiectasis, Multifocal                          2 (4%)       1 (2%)                                                          
      Basophilic Focus                                 5 (10%)                   1 (2%)                                             
      Basophilic Focus, Multiple                       2 (4%)       5 (10%)      1 (2%)                                             
      Clear Cell Focus                                 5 (10%)      1 (2%)       4 (8%)                                             
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Degeneration, Cystic                             4 (8%)       5 (10%)      1 (2%)                                             
      Developmental Malformation                       7 (14%)      3 (6%)       2 (4%)                                             
      Eosinophilic Focus                                                         1 (2%)                                             
      Granuloma, Multifocal                            1 (2%)       5 (10%)      6 (12%)                                            
      Mixed Cell Focus                                 1 (2%)                    2 (4%)                                             
      Necrosis, Multifocal                             1 (2%)                    1 (2%)                                             
      Regeneration                                                  1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                              4 (8%)       1 (2%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
      Biliary Tract, Proliferation                    40 (80%)     33 (66%)     40 (80%)                                            
      Centrilobular, Necrosis                         14 (28%)     20 (40%)     16 (32%)                                            
      Serosa, Inflammation, Acute, Focal,                                                                                           
          Suppurative                                  1 (2%)                                                                       
   Mesentery                                          (2)          (4)          (6)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization, Multifocal                       1 (50%)                                                                      
      Fat, Necrosis, Focal                             2 (100%)     2 (50%)      4 (67%)                                            
      Fat, Necrosis, Multifocal                                     1 (25%)                                                         
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy, Focal                                  22 (44%)     27 (54%)     22 (44%)                                            
      Basophilic Focus                                 3 (6%)                                                                       
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)                    3 (6%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Artery, Mineralization, Multifocal               1 (2%)       1 (2%)       1 (2%)                                             
      Artery, Thrombosis                                            1 (2%)       1 (2%)                                             
   Stomach                                            (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Artery, Mineralization, Diffuse                  1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                                3 (6%)       3 (6%)                                             
      Hyperplasia                                      1 (2%)       4 (8%)       3 (6%)                                             
      Inflammation, Acute, Suppurative                 1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization, Diffuse                          3 (6%)       4 (8%)       5 (10%)                                            
      Perforation                                      1 (2%)       2 (4%)                                                          
      Ulcer                                            2 (4%)       2 (4%)       2 (4%)                                             
      Ulcer, Multiple                                               1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Edema                                            1 (2%)       4 (8%)       1 (2%)                                             
      Erosion                                          1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Diffuse                                             2 (4%)                                             
      Mineralization, Diffuse                          4 (8%)       6 (12%)      8 (16%)                                            
      Ulcer                                            1 (2%)                                                                       
      Ulcer, Multiple                                  1 (2%)                    1 (2%)                                             
   Tongue                                                                       (3)                                                 
      Hyperkeratosis, Focal                                                      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)          (5)          (6)                                                 
      Aorta, Mineralization, Diffuse                   3 (100%)     5 (100%)     6 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  44 (88%)     46 (92%)     45 (90%)                                            
      Mineralization, Multifocal                       2 (4%)       4 (8%)       5 (10%)                                            
      Atrium, Thrombosis                               2 (4%)       3 (6%)       4 (8%)                                             
      Endocardium, Inflammation, Chronic, Focal                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                3 (6%)                                                                       
      Degeneration, Fatty, Focal                       9 (18%)     10 (20%)     15 (30%)                                            
      Degeneration, Fatty, Multifocal                  1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (50)                                                
      Hyperplasia, Focal                              10 (20%)      1 (2%)      10 (20%)                                            
      Mineralization, Multifocal                       1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia, Focal                                            1 (2%)                                                          
   Parathyroid Gland                                  (46)         (47)         (45)                                                
      Hyperplasia                                      3 (7%)       9 (19%)      9 (20%)                                            
   Pituitary Gland                                    (50)         (48)         (48)                                                
      Pars Distalis, Angiectasis                       9 (18%)     12 (25%)      7 (15%)                                            
      Pars Distalis, Cyst                              4 (8%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                8 (16%)     11 (23%)      6 (13%)                                            
      Pars Distalis, Pigmentation, Hemosiderin         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Hyperplasia                              3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                                 (2)          (2)                                                 
      Mineralization, Diffuse                                       2 (100%)     2 (100%)                                           
   Preputial Gland                                    (49)         (48)         (48)                                                
      Foreign Body                                                  1 (2%)                                                          
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Acute, Suppurative                 9 (18%)      5 (10%)      2 (4%)                                             
      Inflammation, Chronic                            2 (4%)       1 (2%)                                                          
      Duct, Cyst                                       8 (16%)      4 (8%)       3 (6%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute, Suppurative                17 (34%)     13 (26%)     17 (34%)                                            
   Seminal Vesicle                                    (3)          (5)          (3)                                                 
      Dilatation                                                                 1 (33%)                                            
      Hyperplasia                                                                1 (33%)                                            
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                         16 (32%)     16 (32%)     17 (34%)                                            
      Hemorrhage                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Mineralization, Focal                            1 (2%)                                                                       
      Arteriole, Inflammation, Chronic                                           1 (2%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   3 (6%)                    5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Hypoplasia                                                    1 (2%)       1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Iliac, Hyperplasia                               1 (2%)                                                                       
      Inguinal, Hyperplasia                                         2 (4%)       1 (2%)                                             
      Mediastinal, Ectasia                             3 (6%)                                                                       
      Mediastinal, Pigmentation                                     1 (2%)       1 (2%)                                             
      Pancreatic, Ectasia                              1 (2%)       1 (2%)                                                          
      Renal, Congestion                                             1 (2%)                                                          
      Renal, Ectasia                                                1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (50)         (50)         (48)                                                
      Ectasia                                         14 (28%)      5 (10%)      4 (8%)                                             
      Hyperplasia                                      3 (6%)       1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (48)                                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Ectasia                                          1 (2%)       2 (4%)       2 (4%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Developmental Malformation                       2 (4%)                                                                       
      Fibrosis, Diffuse                                             1 (2%)                                                          
      Fibrosis, Focal                                  2 (4%)       6 (12%)      6 (12%)                                            
      Hematopoietic Cell Proliferation                 9 (18%)      6 (12%)      6 (12%)                                            
      Hyperplasia, Focal                                                         2 (4%)                                             
      Mineralization, Focal                                                      1 (2%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Necrosis, Multifocal                                                       1 (2%)                                             
      Capsule, Fibrosis, Multifocal                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (49)         (49)                                                
      Duct, Cyst                                      12 (26%)     14 (29%)     10 (20%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)       2 (4%)                                                          
      Foreign Body                                     2 (4%)                    2 (4%)                                             
      Hyperkeratosis, Focal                            2 (4%)                    1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Acute, Focal, Suppurative                       1 (2%)       3 (6%)                                             
      Inflammation, Acute, Multifocal, Suppurative                               1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)       1 (2%)                                                          
      Inflammation, Focal, Granulomatous               3 (6%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                           3 (6%)       5 (10%)      8 (16%)                                            
      Hypertrophy, Focal                                            1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (2)                                                 
      Mineralization, Multifocal                                                 2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Compression                                                   2 (4%)       2 (4%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)       2 (4%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Hemorrhage, Multifocal                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       2 (4%)                                                                       
      Foreign Body                                                               1 (2%)                                             
      Granuloma, Multifocal                                                      1 (2%)                                             
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)       4 (8%)                                             
      Infiltration Cellular, Multifocal, Histiocyte    2 (4%)       1 (2%)       3 (6%)                                             
      Inflammation, Acute, Multifocal, Suppurative                  1 (2%)                                                          
      Mineralization, Multifocal                       3 (6%)       5 (10%)      5 (10%)                                            
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       2 (4%)       1 (2%)                                             
   Nose                                               (49)         (50)         (49)                                                
      Foreign Body                                     5 (10%)                   3 (6%)                                             
      Fungus                                           6 (12%)      2 (4%)       4 (8%)                                             
      Inflammation, Acute, Suppurative                 6 (12%)      2 (4%)       6 (12%)                                            
      Mucosa, Cyst                                     1 (2%)                                                                       
      Nasolacrimal Duct, Foreign Body                  2 (4%)       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  3 (6%)       2 (4%)       1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05058-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             ROXARSONE                                         Date: 09/08/94  
Route: DOSED FEED                                                                                                 Time: 07:31:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.005%       0.01%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (6)          (25)                                                
      Cataract                                         2 (50%)      1 (17%)     21 (84%)                                            
      Hemorrhage                                                                 2 (8%)                                             
      Hyperplasia                                                                1 (4%)                                             
      Cornea, Inflammation, Acute, Suppurative                      1 (17%)                                                         
      Retina, Degeneration                             3 (75%)      2 (33%)     23 (92%)                                            
   Harderian Gland                                                              (1)                                                 
      Inflammation, Chronic, Focal                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Mineralization, Diffuse                          3 (6%)       4 (8%)       4 (8%)                                             
      Nephropathy, Chronic                            50 (100%)    49 (98%)     49 (98%)                                            
      Cortex, Cyst                                     5 (10%)      9 (18%)      8 (16%)                                            
      Renal Tubule, Pigmentation, Multifocal                                     1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Hemorrhage, Multifocal                                                     1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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