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TDMS Study 05058-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/08/94   
EXP: 05058                        ROXARSONE                    TIME: 07:49:27   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C56508   
CONT: NOI-ES-28024                                             CAS: 121-19-7    
PATHOLOGIST: H. GILES                                                           
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/08/94  
EXP: 05058                        ROXARSONE                    TIME: 07:49:27  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C56508  
CONT: NOI-ES-28024                                             CAS: 121-19-7   
PATHOLOGIST: H. GILES                                                          

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      283   538   564   581   584   585   616   625   636   636                 |
 |      647   651   661   666   671   675   679   679   693   695                 |
 |      700   703   703   710   716   727                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.005%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      495   496   535   580   581   593   608   625   629   629                 |
 |      630   633   633   637   637   656   661   673   679   681                 |
 |      684   684   685   693   701   705   710   721   722   722                 |
 |      723   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.01%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      534   553   581   581   595   630   634   637   638   647                 |
 |      651   656   664   666   671   671   677   677   678   681                 |
 |      683   683   686   690   695   701   714   715   723   724                 |
 |      727   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0  98.0  98.0  98.0  96.0  88.0  74.0  48.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.005%     |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  66.0  36.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.01%      |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  90.0  74.0  36.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.005%           0.01%         |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       48.0%            36.0%            36.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.378          P=0.333          P=0.398       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       639.4            649.0            662.2         |
 |NATURAL DEATHS (C)      |       (17.4)           (11.1)           ( 8.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       682.4            677.8            686.3         |
 |(STANDARD ERROR)        |       (11.0)           ( 8.9)           ( 7.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      404   485   526   538   582   589   591   630   632   635                 |
 |      636   647   647   647   686   687   700   701   702   703                 |
 |      722   722   728                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.005%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      481   486   498   526   539   544   567   581   602   608                 |
 |      685   686   700   703   728                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.01%                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395   407   517   530   637   649   677   678   685   686                 |
 |      697   703   714   723   724   724   727   727                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     ROXARSONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0 100.0  98.0  96.0  92.0  86.0  72.0  54.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.005%     |   100.0 100.0 100.0 100.0 100.0  98.0  88.0  82.0  80.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.01%      |   100.0 100.0 100.0 100.0  96.0  96.0  92.0  92.0  88.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.005%           0.01%         |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%            70.0%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.284N         P=0.205N         P=0.300N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       632.2            595.6            644.4         |
 |NATURAL DEATHS (C)      |       (17.3)           (22.1)           (25.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       684.5            689.0            698.6         |
 |(STANDARD ERROR)        |       (10.4)           (10.9)           (10.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             ROXARSONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.005%           = 2
                                                        0.01%            = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                            1                                2      3
      |                                              1                                       1 3
      |                                                                               2      1 3 1 1
      |                                                                                            11 3
   90 +                                                                                            2  2    3
      |                                                                                             1 2 21 33
P     |                                                                                                 21 113
E     |                                                                                                      33
R  80 +                                                                                                     1 1
C     |                                                                                                    22 33
E     |                                                                                                       13 11
N     |
T  70 +                                                                                                     2  2  11
      |                                                                                                        2 233
S     |                                                                                                          2 1 1
U     |                                                                                                            2211
R  60 +
V     |                                                                                                               11
I     |                                                                                                             22 11
V     |                                                                                                              23211
A  50 +                                                                                                               33 11
L     |                                                                                                                22 1 1
      |                                                                                                                 222
      |
   40 +
      |
      |                                                                                                                   2 2
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 32 obs hidden.

                                                             ROXARSONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.005%           = 2
                                                        0.01%            = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                              31           2
      |
      |                                                                313          21
      |                                                                  3           1 2 3  1
   95 +
      |                                                                                2 3  11
      |                                                                                     21      1       3
      |
   90 +                                                                                      22     1 1     3 3
      |
      |                                                                                       2  2            3    3
      |                                                                                          2 2  1    1
P  85 +
E     |                                                                                            2   2   11      33
R     |                                                                                                22
C     |
E  80 +                                                                                                 2           2 3
N     |
T     |                                                                                                     1 1       33
      |                                                                                                             2 233
S  75 +
U     |                                                                                                               223 3
R     |                                                                                                       1     1  2  2
V     |
I  70 +                                                                                                             11    2 2
V     |
A     |                                                                                                              11
L     |                                                                                                               11
   65 +
      |                                                                                                                   3 3
      |
      |
   60 +                                                                                                                1  1
      |
      |
      |
   55 +
      |                                                                                                                   1 1
      |
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

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