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https://ntp.niehs.nih.gov/go/1760

TDMS Study 05063-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           PHENYLBUTAZONE


NTP Experiment-Test: 05063-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 21:00:16




       Facility:  TSI Mason Research

       Chemical CAS #:  50-33-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           11            5                                                  
    Natural Death                                      8            9           12                                                  
    Dead                                                            1                                                               
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           29           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (14)         (44)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Gallbladder                                        (44)         (28)         (47)                                                
      Inflammation, Acute                              4 (9%)                    3 (6%)                                             
      Inflammation, Chronic                            7 (16%)                   7 (15%)                                            
      Inflammation, Chronic Active                     2 (5%)                                                                       
   Intestine Large, Cecum                             (50)         (8)          (40)                                                
      Mesothelium, Hyperplasia                                                   1 (3%)                                             
      Serosa, Inflammation, Chronic Active             2 (4%)                                                                       
   Intestine Large, Colon                             (50)         (16)         (48)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Mesothelium, Hyperplasia                         1 (2%)                    1 (2%)                                             
      Muscularis, Inflammation, Chronic Active         1 (2%)                                                                       
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Large, Rectum                            (48)         (11)         (43)                                                
      Mesothelium, Hyperplasia                                                   1 (2%)                                             
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (15)         (46)                                                
      Mesothelium, Hyperplasia                         1 (2%)                    1 (2%)                                             
      Serosa, Fibrosis                                 1 (2%)                                                                       
      Serosa, Inflammation, Chronic Active             2 (4%)                                                                       
   Intestine Small, Ileum                             (46)         (15)         (44)                                                
      Lymphoid Nodule, Hyperplasia                     3 (7%)                                                                       
      Mesothelium, Hyperplasia                         2 (4%)                    1 (2%)                                             
      Mucosa, Vacuolization Cytoplasmic                1 (2%)                                                                       
      Serosa, Inflammation, Acute                                   2 (13%)                                                         
   Intestine Small, Jejunum                           (49)         (15)         (45)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Mesothelium, Hyperplasia                         3 (6%)                    1 (2%)                                             
      Serosa, Inflammation, Chronic Active             2 (4%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Liver                                              (50)         (49)         (50)                                                
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Clear Cell Focus                                                           1 (2%)                                             
      Congestion                                       2 (4%)                    1 (2%)                                             
      Degeneration                                                  1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       1 (2%)                                                          
      Fatty Change                                     5 (10%)      6 (12%)                                                         
      Hematopoietic Cell Proliferation                19 (38%)      3 (6%)       7 (14%)                                            
      Hemorrhage                                                    6 (12%)      1 (2%)                                             
      Inflammation, Acute                              3 (6%)                                                                       
      Inflammation, Chronic                           12 (24%)      7 (14%)      3 (6%)                                             
      Inflammation, Chronic Active                     1 (2%)       7 (14%)                                                         
      Mixed Cell Focus                                              3 (6%)                                                          
      Necrosis, Coagulative                            8 (16%)     14 (29%)     12 (24%)                                            
      Pigmentation                                                  2 (4%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       2 (4%)                                                          
      Periportal, Inflammation, Chronic               19 (38%)     16 (33%)     21 (42%)                                            
      Serosa, Inflammation, Acute                      5 (10%)      1 (2%)       4 (8%)                                             
   Mesentery                                          (9)          (8)          (4)                                                 
      Abscess                                                       1 (13%)                                                         
      Fibrosis                                                                   1 (25%)                                            
      Inflammation, Acute                              1 (11%)      3 (38%)      1 (25%)                                            
      Inflammation, Chronic                            1 (11%)                                                                      
      Inflammation, Chronic Active                     5 (56%)      1 (13%)      2 (50%)                                            
      Necrosis                                         1 (11%)      1 (13%)      1 (25%)                                            
   Pancreas                                           (50)         (19)         (49)                                                
      Abscess                                                       2 (11%)      1 (2%)                                             
      Atrophy                                          2 (4%)                    2 (4%)                                             
      Fatty Change                                     1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)       1 (5%)                                                          
      Inflammation, Chronic                           17 (34%)      2 (11%)     20 (41%)                                            
      Inflammation, Chronic Active                     5 (10%)                                                                      
      Duct, Dilatation                                 1 (2%)                    1 (2%)                                             
      Serosa, Fibrosis                                 2 (4%)                                                                       
      Serosa, Inflammation, Acute                      5 (10%)      3 (16%)      1 (2%)                                             
      Serosa, Inflammation, Chronic Active             3 (6%)                    3 (6%)                                             
   Salivary Glands                                    (48)         (16)         (49)                                                
      Parotid Gland, Inflammation, Chronic             2 (4%)                                                                       
      Sublingual Gland, Inflammation, Chronic          3 (6%)                    3 (6%)                                             
      Submandibular Gland, Atrophy                                  1 (6%)                                                          
      Submandibular Gland, Inflammation, Chronic      26 (54%)      4 (25%)     27 (55%)                                            
   Stomach, Forestomach                               (50)         (16)         (48)                                                
      Acanthosis                                       3 (6%)                    4 (8%)                                             
      Hyperkeratosis                                   4 (8%)                    4 (8%)                                             
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Inflammation, Chronic                            3 (6%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing        1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (16)         (48)                                                
      Inflammation, Chronic                           13 (27%)                  13 (27%)                                            
      Inflammation, Chronic Active                     5 (10%)                   3 (6%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Tooth                                              (35)                      (28)                                                
      Dysplasia                                        1 (3%)                                                                       
      Incisor, Abscess                                 3 (9%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Bacterium                                        1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Inflammation, Chronic                            5 (10%)                   6 (12%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                                1 (6%)       1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
      Coronary Artery, Perivascular, Inflammation,                                                                                  
           Acute                                       1 (2%)                                                                       
      Coronary Artery, Perivascular, Inflammation,                                                                                  
           Chronic Active                              1 (2%)                                                                       
      Epicardium, Inflammation, Acute                               1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (15)         (49)                                                
      Capsule, Inflammation, Chronic Active            6 (13%)                   3 (6%)                                             
   Adrenal Gland, Cortex                              (48)         (15)         (49)                                                
      Angiectasis                                      2 (4%)                    1 (2%)                                             
      Congestion                                                    1 (7%)                                                          
      Cyst                                             2 (4%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (47)         (15)         (48)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (31)         (8)          (30)                                                
      Cyst                                             1 (3%)       1 (13%)                                                         
   Pituitary Gland                                    (44)         (17)         (47)                                                
      Pars Distalis, Angiectasis                                    4 (24%)      2 (4%)                                             
      Pars Distalis, Congestion                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              1 (2%)       1 (6%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      16 (36%)      3 (18%)     22 (47%)                                            
   Thyroid Gland                                      (48)         (14)         (50)                                                
      Inflammation, Chronic                            1 (2%)                    3 (6%)                                             
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicle, Cyst                                   2 (4%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                     4 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                  (2)                                                              
      Cyst                                                          1 (50%)                                                         
   Ovary                                              (50)         (47)         (47)                                                
      Abscess                                         19 (38%)      4 (9%)      10 (21%)                                            
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Cyst                                             7 (14%)      9 (19%)     16 (34%)                                            
      Hemorrhage                                       2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                                                      1 (2%)                                             
      Pigmentation                                                  6 (13%)                                                         
      Periovarian Tissue, Cyst                         4 (8%)       5 (11%)      2 (4%)                                             
      Periovarian Tissue, Hemorrhage                                1 (2%)                                                          
      Periovarian Tissue, Inflammation, Acute                       1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic       14 (28%)                   5 (11%)                                            
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                       1 (2%)       1 (2%)       1 (2%)                                             
      Periovarian Tissue, Necrosis                                  1 (2%)                                                          
      Periovarian Tissue, Thrombosis                                1 (2%)                                                          
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Oviduct                                            (8)                                                                           
      Inflammation, Acute                              6 (75%)                                                                      
      Inflammation, Acute, Hemorrhagic                 1 (13%)                                                                      
      Inflammation, Chronic Active                     1 (13%)                                                                      
   Uterus                                             (50)         (49)         (48)                                                
      Abscess                                          3 (6%)       4 (8%)       2 (4%)                                             
      Hydrometra                                       1 (2%)                    1 (2%)                                             
      Inflammation, Acute                             19 (38%)      5 (10%)      9 (19%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                    4 (8%)                                             
      Necrosis, Coagulative                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Pigmentation                                                  1 (2%)                                                          
      Endometrium, Hyperplasia                        50 (100%)    42 (86%)     41 (85%)                                            
      Muscularis, Congestion                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (50)                                                
      Bacterium                                        1 (2%)                                                                       
      Congestion                                                    1 (7%)       4 (8%)                                             
      Hypoplasia                                                                 3 (6%)                                             
      Myelofibrosis                                   42 (84%)      1 (7%)      28 (56%)                                            
      Myeloid Cell, Hyperplasia                        4 (8%)       2 (13%)      1 (2%)                                             
   Lymph Node                                         (47)         (24)         (48)                                                
      Bronchial, Inflammation, Chronic Active                       1 (4%)                                                          
      Lumbar, Bacterium                                1 (2%)                                                                       
      Lumbar, Hemorrhage                                            1 (4%)                                                          
      Lumbar, Hyperplasia, Lymphoid                                 1 (4%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                 9 (19%)      1 (4%)       2 (4%)                                             
      Lumbar, Inflammation, Acute                                                1 (2%)                                             
      Lumbar, Inflammation, Chronic Active             4 (9%)                                                                       
      Mediastinal, Abscess                                          1 (4%)       1 (2%)                                             
      Mediastinal, Congestion                          1 (2%)                                                                       
      Mediastinal, Depletion Lymphoid                  2 (4%)       1 (4%)                                                          
      Mediastinal, Hemorrhage                          2 (4%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)       1 (4%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell            6 (13%)                   2 (4%)                                             
      Mediastinal, Inflammation, Acute                 4 (9%)       2 (8%)       2 (4%)                                             
      Mediastinal, Inflammation, Chronic Active                                  1 (2%)                                             
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Pancreatic, Hemorrhage                           1 (2%)       1 (4%)                                                          
      Pancreatic, Hyperplasia, Plasma Cell             2 (4%)                    2 (4%)                                             
      Pancreatic, Inflammation, Acute                  2 (4%)                                                                       
      Renal, Bacterium                                 1 (2%)                                                                       
      Renal, Hemorrhage                                1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                                  1 (4%)                                                          
      Renal, Hyperplasia, Plasma Cell                 11 (23%)      3 (13%)      7 (15%)                                            
      Renal, Inflammation, Acute                                    1 (4%)       3 (6%)                                             
      Renal, Inflammation, Chronic Active              2 (4%)                                                                       
   Lymph Node, Mandibular                             (34)         (12)         (30)                                                
      Depletion Lymphoid                               1 (3%)       1 (8%)       1 (3%)                                             
      Ectasia                                                                    1 (3%)                                             
      Hyperplasia, Plasma Cell                         3 (9%)                                                                       
      Inflammation, Acute                              1 (3%)                                                                       
   Lymph Node, Mesenteric                             (42)         (18)         (41)                                                
      Abscess                                                       1 (6%)                                                          
      Angiectasis                                      5 (12%)      1 (6%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                       1 (2%)                                                                       
      Depletion Lymphoid                               2 (5%)       1 (6%)                                                          
      Hemorrhage                                       2 (5%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            4 (10%)      1 (6%)       2 (5%)                                             
      Hyperplasia, Plasma Cell                         2 (5%)                    1 (2%)                                             
      Inflammation, Acute                              3 (7%)       1 (6%)       1 (2%)                                             
      Inflammation, Acute, Necrotizing                              1 (6%)                                                          
      Inflammation, Chronic                                         1 (6%)                                                          
      Inflammation, Chronic Active                     2 (5%)       1 (6%)                                                          
      Necrosis                                                      1 (6%)                                                          
      Serosa, Congestion                               1 (2%)                                                                       
      Serosa, Fibrosis                                 1 (2%)                                                                       
      Serosa, Inflammation, Chronic Active             1 (2%)                                                                       
   Spleen                                             (50)         (29)         (49)                                                
      Angiectasis                                      1 (2%)       1 (3%)                                                          
      Congestion                                                    1 (3%)       1 (2%)                                             
      Depletion Lymphoid                               4 (8%)       6 (21%)      7 (14%)                                            
      Hematopoietic Cell Proliferation                23 (46%)      8 (28%)      8 (16%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            9 (18%)      1 (3%)       8 (16%)                                            
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis, Coagulative                            1 (2%)                                                                       
      Capsule, Abscess                                 1 (2%)                                                                       
      Capsule, Fibrosis                                1 (2%)                                                                       
      Capsule, Inflammation, Acute                     3 (6%)       1 (3%)                                                          
      Capsule, Inflammation, Chronic Active                         1 (3%)                                                          
   Thymus                                             (37)         (11)         (39)                                                
      Cyst                                                          1 (9%)                                                          
      Depletion Lymphoid                               9 (24%)      7 (64%)      6 (15%)                                            
      Hemorrhage                                       3 (8%)       1 (9%)       1 (3%)                                             
      Hyperplasia, Lymphoid                                                      2 (5%)                                             
      Inflammation, Acute                              2 (5%)                                                                       
      Necrosis                                                      3 (27%)      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (5)          (23)                                                
      Galactocele                                      1 (3%)                                                                       
      Hyperplasia                                      2 (6%)                    1 (4%)                                             
      Infiltration Cellular, Mixed Cell                1 (3%)                                                                       
      Inflammation, Chronic                            3 (10%)                                                                      
   Skin                                               (49)         (16)         (48)                                                
      Inflammation, Acute, Necrotizing                 2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosis                                              2 (4%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (4)          (4)                                                 
      Intercostal, Inflammation, Acute                              1 (25%)                                                         
      Thoracic, Inflammation, Acute                                 1 (25%)      2 (50%)                                            
      Thoracic, Inflammation, Chronic Active                                     1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (50)                                                
      Bacterium                                        1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
      Infarct, Multifocal                              1 (2%)                                                                       
      Cerebellum, Inflammation, Chronic                                          1 (2%)                                             
      Thalamus, Mineralization                        40 (80%)      4 (25%)     25 (50%)                                            
   Spinal Cord                                        (1)          (1)                                                              
      Hemorrhage, Focal                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (21)         (50)                                                
      Bacterium                                                                  2 (4%)                                             
      Congestion                                       2 (4%)       2 (10%)      1 (2%)                                             
      Hemorrhage                                       6 (12%)                   3 (6%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       1 (5%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                                               2 (4%)                                             
      Leukocytosis                                     3 (6%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (4%)                                             
      Artery, Hyperplasia                              1 (2%)                                                                       
      Artery, Thrombosis                               1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
      Peribronchiolar, Inflammation, Chronic           1 (2%)                    1 (2%)                                             
      Perivascular, Inflammation, Acute                4 (8%)                    1 (2%)                                             
      Perivascular, Inflammation, Chronic              3 (6%)       2 (10%)      3 (6%)                                             
      Perivascular, Inflammation, Chronic Active       1 (2%)                    1 (2%)                                             
      Pleura, Inflammation, Acute                      2 (4%)       1 (5%)       1 (2%)                                             
      Pleura, Inflammation, Chronic                    1 (2%)                    1 (2%)                                             
      Pleura, Inflammation, Chronic Active                          1 (5%)                                                          
      Pleura, Inflammation, Chronic Active,                                                                                         
          Hemorrhagic                                  1 (2%)                                                                       
   Nose                                               (50)         (12)         (41)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Lumen, Inflammation, Acute                       4 (8%)                    2 (5%)                                             
      Mucosa, Glands, Dilatation                                                 1 (2%)                                             
      Mucosa, Glands, Inflammation, Acute             18 (36%)                  19 (46%)                                            
      Mucosa, Glands, Inflammation, Chronic Active     1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute                        1 (8%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic                      3 (25%)                                                         
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       5 (10%)                   4 (10%)                                            
   Trachea                                            (49)         (15)         (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Hyperplasia                                                   1 (100%)     1 (100%)                                           
      Inflammation, Acute, Necrotizing                 1 (50%)                                                                      
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Bacterium                                        1 (2%)       1 (2%)       1 (2%)                                             
      Glomerulosclerosis                              15 (30%)      2 (4%)       2 (4%)                                             
      Hydronephrosis                                                             1 (2%)                                             
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Inflammation, Chronic                           44 (88%)     39 (78%)     41 (82%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Osseous                              2 (4%)       1 (2%)       2 (4%)                                             
      Necrosis, Coagulative, Focal                     1 (2%)                                                                       
      Artery, Thrombosis                                                         1 (2%)                                             
      Capsule, Inflammation, Acute                     1 (2%)                                                                       
      Papilla, Inflammation, Acute, Necrotizing                     1 (2%)                                                          
      Proximal Convoluted Renal Tubule, Atrophy        1 (2%)       2 (4%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Regeneration                                 7 (14%)      1 (2%)       9 (18%)                                            
   Urinary Bladder                                    (50)         (16)         (48)                                                
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           38 (76%)      6 (38%)     36 (75%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Serosa, Inflammation, Acute                      2 (4%)                                                                       
      Serosa, Inflammation, Chronic Active             2 (4%)                                                                       
      Submucosa, Fibrosis                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12            6           11                                                  
    Natural Death                                      2            2            3                                                  
    Accident                                                        2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           40           36                                                  
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (46)         (4)          (43)                                                
      Necrosis                                                      1 (25%)                                                         
      Adventitia, Inflammation, Acute                               1 (25%)                                                         
   Gallbladder                                        (45)         (20)         (39)                                                
      Calculus Micro Observation Only                               1 (5%)                                                          
      Fibrosis                                                      1 (5%)                                                          
      Inflammation, Chronic                            5 (11%)                   6 (15%)                                            
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Epithelium, Hyperplasia                                                    1 (3%)                                             
   Intestine Large, Cecum                             (48)         (3)          (46)                                                
      Hyperplasia, Lymphoid                            5 (10%)                   1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Large, Colon                             (49)         (5)          (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Large, Rectum                            (48)         (3)          (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Duodenum                          (49)         (5)          (50)                                                
      Epithelium, Hyperplasia                                       2 (40%)                                                         
   Intestine Small, Ileum                             (49)         (9)          (50)                                                
      Hyperplasia, Lymphoid                            4 (8%)       1 (11%)      1 (2%)                                             
      Lymphoid Tissue, Necrosis                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (3)          (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Peyer's Patch, Inflammation, Chronic Active                                1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Abscess                                                       1 (2%)                                                          
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)       1 (2%)       2 (4%)                                             
      Clear Cell Focus                                                           5 (10%)                                            
      Cyst                                                                       1 (2%)                                             
      Degeneration                                                 22 (44%)     38 (76%)                                            
      Eosinophilic Focus                                            2 (4%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change                                    11 (22%)      7 (14%)     20 (40%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       4 (8%)                                                          
      Hemorrhage                                       1 (2%)      16 (32%)     27 (54%)                                            
      Infarct                                          1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            8 (16%)      6 (12%)      8 (16%)                                            
      Inflammation, Chronic Active                     2 (4%)       5 (10%)      8 (16%)                                            
      Karyomegaly                                                                1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                              2 (4%)       2 (4%)                                             
      Necrosis, Coagulative                            4 (8%)      11 (22%)     36 (72%)                                            
      Pigmentation                                     1 (2%)       1 (2%)      26 (52%)                                            
      Regeneration                                                  1 (2%)                                                          
      Centrilobular, Cytomegaly                                    34 (68%)     45 (90%)                                            
      Centrilobular, Karyomegaly                                   34 (68%)     44 (88%)                                            
      Periportal, Inflammation, Chronic               16 (32%)      2 (4%)       2 (4%)                                             
   Mesentery                                          (4)          (2)          (2)                                                 
      Fibrosis                                         4 (100%)     1 (50%)      1 (50%)                                            
      Inflammation, Chronic                            1 (25%)      1 (50%)      1 (50%)                                            
      Inflammation, Chronic Active                                  1 (50%)      1 (50%)                                            
      Mineralization                                   3 (75%)                                                                      
      Necrosis, Coagulative                            3 (75%)      2 (100%)                                                        
      Pigmentation                                                               1 (50%)                                            
      Artery, Thrombosis                               1 (25%)                                                                      
   Pancreas                                           (49)         (8)          (49)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Ectopic Tissue                                   1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                           17 (35%)                  11 (22%)                                            
      Inflammation, Chronic Active                                  2 (25%)      1 (2%)                                             
      Necrosis, Coagulative                            1 (2%)       1 (13%)                                                         
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Artery, Mineralization                           5 (10%)                   2 (4%)                                             
      Duct, Dilatation                                 1 (2%)                                                                       
   Salivary Glands                                    (50)         (4)          (50)                                                
      Parotid Gland, Inflammation, Chronic             1 (2%)                    1 (2%)                                             
      Parotid Gland, Mineralization                    2 (4%)                                                                       
      Sublingual Gland, Inflammation, Chronic                                    1 (2%)                                             
      Submandibular Gland, Inflammation, Chronic      42 (84%)      1 (25%)     40 (80%)                                            
   Stomach, Forestomach                               (48)         (5)          (50)                                                
      Acanthosis                                       4 (8%)                    4 (8%)                                             
      Hyperkeratosis                                   5 (10%)                   6 (12%)                                            
      Hyperplasia, Basal Cell                          4 (8%)                    3 (6%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     3 (6%)                    4 (8%)                                             
      Inflammation, Chronic Active, Necrotizing                                  1 (2%)                                             
      Karyomegaly, Chronic Active                      1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Mineralization                       1 (2%)                                                                       
      Muscularis, Mineralization                                                 1 (2%)                                             
   Stomach, Glandular                                 (48)         (5)          (50)                                                
      Cyst                                             2 (4%)                                                                       
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           12 (25%)      1 (20%)      8 (16%)                                            
      Inflammation, Chronic Active                     2 (4%)                    5 (10%)                                            
      Pigmentation                                                               1 (2%)                                             
      Muscularis, Mineralization                                                 1 (2%)                                             
   Tooth                                              (17)                      (5)                                                 
      Incisor, Abscess                                 8 (47%)                   4 (80%)                                            
      Incisor, Bacterium                                                         1 (20%)                                            
      Incisor, Dysplasia                               9 (53%)                   2 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (50)                                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                           10 (20%)                   3 (6%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Coronary Artery, Mineralization                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (8)          (48)                                                
      Capsule, Inflammation, Chronic                   1 (2%)                                                                       
   Adrenal Gland, Cortex                              (49)         (8)          (48)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      5 (10%)                   2 (4%)                                             
      Pigmentation                                     1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (48)         (8)          (48)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                                                3 (6%)                                             
   Islets, Pancreatic                                 (49)         (5)          (50)                                                
      Hyperplasia                                                                1 (2%)                                             
   Parathyroid Gland                                  (27)         (3)          (34)                                                
      Vacuolization Cytoplasmic                                                  1 (3%)                                             
   Pituitary Gland                                    (47)         (5)          (45)                                                
      Pars Distalis, Cyst                              7 (15%)      1 (20%)      1 (2%)                                             
      Pars Distalis, Hyperplasia                       3 (6%)       1 (20%)      6 (13%)                                            
   Thyroid Gland                                      (48)         (5)          (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)          (11)                                                
      Inflammation, Chronic                                                      1 (9%)                                             
      Perivascular, Inflammation, Chronic                                        1 (9%)                                             
   Epididymis                                         (49)         (4)          (50)                                                
      Inflammation, Chronic                           20 (41%)                  20 (40%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Preputial Gland                                    (10)         (14)         (8)                                                 
      Abscess                                          6 (60%)      4 (29%)                                                         
      Cyst                                                          1 (7%)                                                          
      Hemorrhage                                                                 1 (13%)                                            
      Inflammation, Chronic                            2 (20%)      2 (14%)      1 (13%)                                            
      Inflammation, Chronic Active                     2 (20%)      4 (29%)      5 (63%)                                            
      Inflammation, Chronic Active, Necrotizing                     2 (14%)                                                         
      Duct, Dilatation                                 2 (20%)      1 (7%)                                                          
   Prostate                                           (49)         (5)          (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
      Inflammation, Chronic                           36 (73%)      1 (20%)     33 (66%)                                            
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (6)          (50)                                                
      Atrophy                                                       1 (17%)                                                         
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           22 (44%)                   8 (16%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
   Testes                                             (50)         (7)          (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic Active                                  1 (14%)                                                         
      Seminiferous Tubule, Atrophy                     2 (4%)       1 (14%)      3 (6%)                                             
      Seminiferous Tubule, Giant Cell                                            1 (2%)                                             
      Seminiferous Tubule, Mineralization              1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (5)          (50)                                                
      Congestion                                                    1 (20%)      2 (4%)                                             
      Infarct                                                       1 (20%)                                                         
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (20%)                                                         
   Lymph Node                                         (50)         (27)         (50)                                                
      Axillary, Hyperplasia, Lymphoid                               1 (4%)                                                          
      Axillary, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Bronchial, Hyperplasia, Lymphoid                                           1 (2%)                                             
      Inguinal, Angiectasis                            1 (2%)                                                                       
      Inguinal, Ectasia                                1 (2%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Inguinal, Inflammation, Acute                                              1 (2%)                                             
      Inguinal, Pigmentation                                                     2 (4%)                                             
      Lumbar, Hyperplasia, Lymphoid                    2 (4%)       1 (4%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                 1 (2%)       1 (4%)                                                          
      Lumbar, Pigmentation                             1 (2%)                                                                       
      Mediastinal, Angiectasis                                                   1 (2%)                                             
      Mediastinal, Depletion Lymphoid                                            1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Pigmentation                                                  1 (2%)                                             
      Pancreatic, Angiectasis                                                    1 (2%)                                             
      Pancreatic, Depletion Lymphoid                                             1 (2%)                                             
      Pancreatic, Ectasia                                                        1 (2%)                                             
      Pancreatic, Hematopoietic Cell Proliferation                               1 (2%)                                             
      Pancreatic, Hemorrhage                                        1 (4%)                                                          
      Renal, Hemorrhage                                             1 (4%)                                                          
      Renal, Hyperplasia, Lymphoid                     2 (4%)       1 (4%)                                                          
   Lymph Node, Mandibular                             (27)         (1)          (23)                                                
      Depletion Lymphoid                               1 (4%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (4%)                                             
      Hyperplasia, Plasma Cell                         2 (7%)                                                                       
      Pigmentation                                                               2 (9%)                                             
   Lymph Node, Mesenteric                             (45)         (20)         (47)                                                
      Angiectasis                                     28 (62%)      3 (15%)     30 (64%)                                            
      Depletion Lymphoid                               1 (2%)                    2 (4%)                                             
      Ectasia                                          2 (4%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (5%)                                                          
      Hemorrhage                                       3 (7%)      14 (70%)      3 (6%)                                             
      Hyperplasia, Lymphoid                            3 (7%)       1 (5%)       5 (11%)                                            
      Infiltration Cellular, Histiocyte                             1 (5%)       1 (2%)                                             
      Inflammation, Acute                              2 (4%)                                                                       
      Pigmentation                                                  1 (5%)                                                          
      Thrombosis                                       2 (4%)                                                                       
   Spleen                                             (50)         (20)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                               1 (2%)                    5 (10%)                                            
      Hematopoietic Cell Proliferation                 7 (14%)      5 (25%)      7 (14%)                                            
      Hyperplasia, Lymphoid                            4 (8%)       3 (15%)      6 (12%)                                            
      Necrosis, Coagulative                            1 (2%)                                                                       
      Artery, Endothelium, Hyperplasia                 1 (2%)                                                                       
   Thymus                                             (41)         (4)          (34)                                                
      Cyst                                            12 (29%)                   7 (21%)                                            
      Depletion Lymphoid                               4 (10%)      4 (100%)     4 (12%)                                            
      Hemorrhage                                       4 (10%)                   2 (6%)                                             
      Necrosis                                         1 (2%)                    1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (11)         (49)                                                
      Acanthosis                                                                 1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                                                 3 (6%)                                             
      Inflammation, Acute                              2 (4%)                    6 (12%)                                            
      Inflammation, Acute, Hemorrhagic                                           1 (2%)                                             
      Inflammation, Acute, Necrotizing                 2 (4%)       1 (9%)       4 (8%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing                     2 (18%)                                                         
      Epidermis, Inflammation, Acute                                1 (9%)                                                          
      Subcutaneous Tissue, Abscess                     1 (2%)       1 (9%)                                                          
      Subcutaneous Tissue, Fibrosis                    2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Granuloma                                             1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                    1 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (33)         (50)                                                
      Joint, Tarsal, Hyperostosis                     33 (66%)     28 (85%)     35 (70%)                                            
   Skeletal Muscle                                    (2)                                                                           
      Abdominal, Regeneration                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (50)                                                
      Hemorrhage                                                    1 (20%)                                                         
      Thalamus, Mineralization                        39 (78%)      1 (20%)     40 (80%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Congestion                                                    3 (21%)                                                         
      Embolus Tumor                                                              1 (2%)                                             
      Hemorrhage                                       5 (10%)      4 (29%)      5 (10%)                                            
      Infiltration Cellular, Histiocyte                3 (6%)                    5 (10%)                                            
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    4 (8%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)                    3 (6%)                                             
      Bronchiole, Epithelium, Hyperplasia              1 (2%)                                                                       
      Fat, Mediastinum, Necrosis, Liquifactive                      1 (7%)                                                          
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
      Peribronchial, Inflammation, Chronic             1 (2%)                                                                       
      Peribronchiolar, Inflammation, Chronic                        1 (7%)                                                          
      Perivascular, Inflammation, Chronic              2 (4%)       1 (7%)       1 (2%)                                             
      Pleura, Inflammation, Acute                      1 (2%)                                                                       
   Nose                                               (50)         (3)          (47)                                                
      Glands, Inflammation, Acute                                   1 (33%)                                                         
      Lumen, Inflammation, Acute                       2 (4%)                    2 (4%)                                             
      Mucosa, Inflammation, Acute                     26 (52%)                  18 (38%)                                            
      Mucosa, Inflammation, Chronic                                              1 (2%)                                             
      Mucosa, Inflammation, Chronic Active             2 (4%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                    3 (6%)                                             
      Nasolacrimal Duct, Metaplasia, Squamous          1 (2%)                    1 (2%)                                             
      Nasopharyngeal Duct, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                                              
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Eye                                                (2)                                                                           
      Cornea, Inflammation, Chronic Active,                                                                                         
          Necrotizing                                  1 (50%)                                                                      
      Lids, Inflammation, Chronic Active,                                                                                           
          Necrotizing                                  1 (50%)                                                                      
   Harderian Gland                                    (3)          (2)          (3)                                                 
      Hyperplasia                                                   1 (50%)      1 (33%)                                            
      Inflammation, Chronic                            1 (33%)                   1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05063-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 21:00:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.15G/KG     0.3 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Bacterium                                        1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Glomerulosclerosis                               4 (8%)       6 (12%)      6 (12%)                                            
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic                           44 (90%)     42 (84%)     47 (94%)                                            
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)                                                                       
      Medulla, Mineralization                                                    1 (2%)                                             
      Papilla, Necrosis, Coagulative                   1 (2%)                                                                       
      Proximal Convoluted Renal Tubule, Atrophy        2 (4%)                                                                       
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration                                              1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Mineralization                               1 (2%)                                                                       
      Proximal Convoluted Renal Tubule,                                                                                             
          Regeneration                                36 (73%)      3 (6%)      36 (72%)                                            
      Proximal Convoluted Renal Tubule,                                                                                             
          Vacuolization Cytoplasmic                    1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
   Ureter                                                                       (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
   Urethra                                            (4)                       (7)                                                 
      Calculus Micro Observation Only                  4 (100%)                  6 (86%)                                            
      Inflammation, Chronic                                                      1 (14%)                                            
   Urinary Bladder                                    (50)         (6)          (48)                                                
      Calculus Gross Observation                       1 (2%)                    1 (2%)                                             
      Calculus Micro Observation Only                  3 (6%)                    3 (6%)                                             
      Inflammation, Chronic                           35 (70%)      2 (33%)     30 (63%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                                1 (17%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
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