National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2292

TDMS Study 05063-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           PHENYLBUTAZONE


NTP Experiment-Test: 05063-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 19:05:34




       Facility:  TSI Mason Research

       Chemical CAS #:  50-33-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14            9           14                                                  
    Natural Death                                      5            5           14                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           35           21                                                  
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (5)          (49)                                                
      Depletion Lymphoid                                                         1 (2%)                                             
      Parasite Metazoan                                1 (2%)       1 (20%)      1 (2%)                                             
   Intestine Large, Colon                             (49)         (7)          (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Parasite Metazoan                                9 (18%)                   6 (12%)                                            
      Mucosa, Fibrosis                                                           1 (2%)                                             
   Intestine Large, Rectum                            (48)         (6)          (48)                                                
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Parasite Metazoan                                1 (2%)                    1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (9)          (50)                                                
      Abscess, Chronic                                                           1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing                                  2 (4%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Muscularis, Inflammation, Acute                                            1 (2%)                                             
      Muscularis, Mineralization                                                 1 (2%)                                             
      Serosa, Fibrosis                                                           1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Intestine Small, Ileum                             (49)         (8)          (50)                                                
      Lymphoid Nodule, Depletion Cellular                                        1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (7)          (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic Active, Necrotizing                                  1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Muscularis, Inflammation, Acute                                            1 (2%)                                             
      Muscularis, Mineralization                                                 1 (2%)                                             
   Liver                                              (50)         (27)         (50)                                                
      Angiectasis                                      1 (2%)       2 (7%)       1 (2%)                                             
      Basophilic Focus                                35 (70%)     14 (52%)     31 (62%)                                            
      Clear Cell Focus                                 4 (8%)       1 (4%)       3 (6%)                                             
      Eosinophilic Focus                                            5 (19%)      2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change                                    20 (40%)     11 (41%)     19 (38%)                                            
      Focal Cellular Change                                                      1 (2%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       3 (11%)      3 (6%)                                             
      Hyperplasia                                      2 (4%)       1 (4%)       2 (4%)                                             
      Inflammation, Chronic Active                    17 (34%)     11 (41%)     10 (20%)                                            
      Mixed Cell Focus                                 2 (4%)                                                                       
      Necrosis, Coagulative                            6 (12%)      3 (11%)      5 (10%)                                            
      Pigmentation                                     1 (2%)                                                                       
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Hyperplasia                          28 (56%)      8 (30%)     23 (46%)                                            
      Centrilobular, Cytomegaly                                                  1 (2%)                                             
      Kupffer Cell, Hyperplasia, Focal                 1 (2%)                    1 (2%)                                             
      Periportal, Fibrosis                             2 (4%)       1 (4%)       1 (2%)                                             
      Serosa, Inflammation, Chronic, Focal                          1 (4%)                                                          
      Serosa, Inflammation, Suppurative                                          1 (2%)                                             
      Subserosa, Necrosis, Coagulative                                           1 (2%)                                             
   Mesentery                                          (2)          (5)          (10)                                                
      Fibrosis                                         1 (50%)      3 (60%)      2 (20%)                                            
      Hemorrhage                                                    1 (20%)      1 (10%)                                            
      Inflammation, Chronic Active                     1 (50%)                   5 (50%)                                            
      Mineralization                                                2 (40%)      4 (40%)                                            
      Necrosis, Coagulative                            1 (50%)      3 (60%)      5 (50%)                                            
   Pancreas                                           (50)         (9)          (50)                                                
      Atrophy                                         11 (22%)      3 (33%)     11 (22%)                                            
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                           12 (24%)      2 (22%)      7 (14%)                                            
   Salivary Glands                                    (50)         (7)          (50)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (49)                                                
      Acanthosis                                       4 (8%)                   12 (24%)                                            
      Edema                                                                      1 (2%)                                             
      Erosion                                                                    1 (2%)                                             
      Hyperkeratosis                                   3 (6%)                   12 (24%)                                            
      Hyperplasia, Basal Cell                          4 (8%)       1 (2%)      12 (24%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)      12 (24%)                                            
      Ulcer, Multiple                                  1 (2%)                                                                       
      Muscularis, Mineralization                                    1 (2%)                                                          
      Submucosa, Foreign Body                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Erosion                                          2 (4%)       1 (2%)       2 (4%)                                             
      Fibrosis                                                      1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                               5 (10%)                                            
      Mineralization                                   1 (2%)                    4 (8%)                                             
      Ulcer                                                                      3 (6%)                                             
      Muscularis, Mineralization                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)                                                                           
      Aorta, Inflammation, Chronic Active              1 (50%)                                                                      
   Heart                                              (50)         (7)          (50)                                                
      Cardiomyopathy                                  35 (70%)      4 (57%)     43 (86%)                                            
      Mineralization                                                             3 (6%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Atrium, Embolus                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Angiectasis                                     30 (60%)     26 (52%)     17 (34%)                                            
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Autolysis                                        1 (2%)       1 (2%)                                                          
      Congestion                                       1 (2%)                                                                       
      Degeneration                                     1 (2%)                                                                       
      Degeneration, Fatty                                                        1 (2%)                                             
      Hyperplasia                                      7 (14%)     12 (24%)      9 (18%)                                            
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)       2 (4%)       2 (4%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic                       24 (48%)     27 (54%)     31 (62%)                                            
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Autolysis                                        1 (2%)       1 (2%)                                                          
      Hyperplasia                                      3 (6%)       6 (12%)     19 (38%)                                            
      Necrosis, Coagulative                                         2 (4%)                                                          
      Thrombosis                                                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (7)          (50)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (31)         (34)         (14)                                                
      Hyperplasia                                                                3 (21%)                                            
   Pituitary Gland                                    (48)         (49)         (50)                                                
      Pars Distalis, Angiectasis                      36 (75%)     19 (39%)     30 (60%)                                            
      Pars Distalis, Cyst                             23 (48%)     26 (53%)     23 (46%)                                            
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      10 (21%)      6 (12%)     15 (30%)                                            
      Pars Distalis, Pigmentation                     12 (25%)      2 (4%)       6 (12%)                                            
      Pars Intermedia, Angiectasis                     2 (4%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Cyst                                         4 (8%)                                                          
      Pars Intermedia, Pigmentation                    2 (4%)                                                                       
      Pars Nervosa, Angiectasis                        2 (4%)       1 (2%)                                                          
      Pars Nervosa, Cyst                               1 (2%)                                                                       
      Pars Nervosa, Pigmentation                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      C-Cell, Hyperplasia                             24 (48%)     26 (53%)     24 (48%)                                            
      Follicular Cell, Cyst                                         1 (2%)                                                          
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (36)         (11)         (41)                                                
      Inflammation, Acute                                           1 (9%)       3 (7%)                                             
      Inflammation, Chronic                            8 (22%)                   6 (15%)                                            
      Inflammation, Chronic Active                    12 (33%)      1 (9%)      17 (41%)                                            
      Inflammation, Chronic Active, Necrotizing                     4 (36%)                                                         
   Ovary                                              (50)         (14)         (50)                                                
      Atrophy                                                       1 (7%)                                                          
      Congestion                                       1 (2%)                                                                       
      Cyst                                             3 (6%)       2 (14%)      2 (4%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Mineralization                                   2 (4%)                                                                       
      Corpus Luteum, Cyst                              1 (2%)                                                                       
      Periovarian Tissue, Cyst                         4 (8%)       4 (29%)                                                         
   Oviduct                                            (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Uterus                                             (50)         (17)         (50)                                                
      Hydrometra                                       6 (12%)      1 (6%)       9 (18%)                                            
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Endometrium, Hyperplasia                         9 (18%)      3 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (6)          (48)                                                
      Myelofibrosis                                    1 (2%)                    1 (2%)                                             
   Lymph Node                                         (50)         (15)         (49)                                                
      Mediastinal, Depletion Lymphoid                               1 (7%)       1 (2%)                                             
      Mediastinal, Ectasia                                          1 (7%)                                                          
      Mediastinal, Hemorrhage                          3 (6%)       3 (20%)     11 (22%)                                            
      Mediastinal, Hyperplasia                         2 (4%)                                                                       
      Mediastinal, Inflammation, Chronic Active                                  1 (2%)                                             
      Mediastinal, Pigmentation                        4 (8%)                                                                       
      Pancreatic, Depletion Lymphoid                   1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte    1 (2%)                                                                       
      Pancreatic, Pigmentation                         3 (6%)                                                                       
      Renal, Angiectasis                               1 (2%)                                                                       
      Renal, Ectasia                                                             1 (2%)                                             
      Renal, Hemorrhage                                1 (2%)                                                                       
      Renal, Hyperplasia                                            1 (7%)                                                          
      Renal, Infiltration Cellular, Histiocyte                                   1 (2%)                                             
      Renal, Pigmentation                                                        1 (2%)                                             
   Lymph Node, Mandibular                             (42)         (5)          (37)                                                
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                                                         1 (3%)                                             
      Ectasia                                          4 (10%)                   1 (3%)                                             
      Hemorrhage                                       6 (14%)      2 (40%)      7 (19%)                                            
      Hyperplasia                                      1 (2%)                    5 (14%)                                            
      Infiltration Cellular, Histiocyte                                          1 (3%)                                             
      Pigmentation                                     1 (2%)                    1 (3%)                                             
   Lymph Node, Mesenteric                             (50)         (13)         (46)                                                
      Depletion Lymphoid                                            1 (8%)       2 (4%)                                             
      Ectasia                                                                    5 (11%)                                            
      Hemorrhage                                       2 (4%)                    4 (9%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Infiltration Cellular, Histiocyte               35 (70%)      5 (38%)     28 (61%)                                            
      Pigmentation                                    34 (68%)      7 (54%)     29 (63%)                                            
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                       2 (4%)       1 (2%)                                                          
      Depletion Lymphoid                              14 (28%)     14 (28%)     19 (38%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                    4 (8%)                                             
      Pigmentation                                     4 (8%)       5 (10%)      1 (2%)                                             
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
      Subcapsular, Necrosis, Coagulative                                         1 (2%)                                             
   Thymus                                             (42)         (8)          (38)                                                
      Congestion                                                    1 (13%)      2 (5%)                                             
      Cyst                                                                       2 (5%)                                             
      Depletion Lymphoid                              28 (67%)      6 (75%)     32 (84%)                                            
      Hemorrhage                                       2 (5%)       2 (25%)                                                         
      Necrosis                                         1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (18)         (40)                                                
      Degeneration                                                               1 (3%)                                             
      Galactocele                                      4 (9%)       1 (6%)       1 (3%)                                             
      Hyperplasia                                     41 (89%)      5 (28%)     32 (80%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Skin                                               (50)         (12)         (49)                                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Granulomatous                                     1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (7)          (50)                                                
      Fibrous Osteodystrophy                                                     1 (2%)                                             
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Hydrocephalus                                    1 (2%)                                                                       
      Cerebellum, Infarct                              2 (4%)                                                                       
      Medulla, Infarct                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (50)                                                
      Congestion                                       1 (2%)       3 (15%)      2 (4%)                                             
      Edema                                                                      2 (4%)                                             
      Foreign Body                                                               4 (8%)                                             
      Granuloma                                                                  1 (2%)                                             
      Hemorrhage                                       4 (8%)       1 (5%)                                                          
      Infiltration Cellular, Histiocyte                9 (18%)      6 (30%)     22 (44%)                                            
      Inflammation, Acute                                                        3 (6%)                                             
      Inflammation, Acute, Necrotizing                 1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           11 (22%)                   8 (16%)                                            
      Inflammation, Chronic Active                     9 (18%)      4 (20%)      6 (12%)                                            
      Thrombosis, Multiple                                                       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 9 (18%)      1 (5%)       2 (4%)                                             
      Artery, Hyperplasia                              1 (2%)                                                                       
      Artery, Mineralization                          18 (36%)      4 (20%)     19 (38%)                                            
      Bronchus, Mineralization                                                   1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (48)         (6)          (49)                                                
      Inflammation, Acute                              4 (8%)                    3 (6%)                                             
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     5 (10%)                   1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing        1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)       1 (17%)      3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Metaplasia, Squamous                       1 (17%)      1 (2%)                                             
   Trachea                                            (50)         (48)         (50)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                                                                           
      Cataract                                         1 (33%)                                                                      
      Retina, Degeneration                             1 (33%)                                                                      
      Sclera, Metaplasia, Osseous                      1 (33%)                                                                      
   Harderian Gland                                    (2)                                                                           
      Hyperplasia                                      1 (50%)                                                                      
      Inflammation, Chronic                            1 (50%)                                                                      
   Lacrimal Gland                                                               (1)                                                 
      Hyperplasia                                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Bacterium                                                                  3 (6%)                                             
      Cyst                                             1 (2%)       2 (4%)      16 (32%)                                            
      Inflammation, Acute, Necrotizing                              1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing                                  2 (4%)                                             
      Nephropathy                                     38 (76%)     46 (92%)     47 (94%)                                            
      Pigmentation                                     2 (4%)                    1 (2%)                                             
      Collecting Tubule, Mineralization                3 (6%)      31 (62%)     46 (92%)                                            
      Distal Convoluted Renal Tubule,                                                                                               
          Mineralization                               1 (2%)                                                                       
      Papilla, Angiectasis                                                       4 (8%)                                             
      Papilla, Inflammation, Acute                                               2 (4%)                                             
      Papilla, Mineralization                                       1 (2%)                                                          
      Papilla, Necrosis                                            18 (36%)     35 (70%)                                            
      Papilla, Necrosis, Coagulative                                             6 (12%)                                            
      Pelvis, Calculus Gross Observation                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pelvis, Dilatation                               1 (2%)                   22 (44%)                                            
      Pelvis, Epithelium, Hyperplasia                  7 (14%)     20 (40%)     37 (74%)                                            
      Pelvis, Epithelium, Mineralization              13 (26%)     11 (22%)      6 (12%)                                            
      Proximal Convoluted Renal Tubule, Hyperplasia                              1 (2%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Inflammation, Acute                          2 (4%)       4 (8%)      26 (52%)                                            
      Proximal Convoluted Renal Tubule,                                                                                             
          Mineralization                               1 (2%)                    4 (8%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Pigmentation                                 4 (8%)       1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)       1 (2%)                                             
   Ureter                                                                       (1)                                                 
      Dilatation                                                                 1 (100%)                                           
   Urinary Bladder                                    (50)         (49)         (49)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Inflammation, Acute, Focal, Necrotizing                                    1 (2%)                                             
      Inflammation, Acute, Necrotizing                              1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                    3 (6%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           13           16                                                  
    Natural Death                                      6           16            7                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           20           27                                                  
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (44)         (17)         (32)                                                
      Inflammation, Acute, Necrotizing                                           1 (3%)                                             
      Submucosa, Hemorrhage                            1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (14)         (50)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Parasite Metazoan                                1 (2%)                    2 (4%)                                             
   Intestine Large, Colon                             (50)         (21)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Parasite Metazoan                               13 (26%)      3 (14%)     12 (24%)                                            
   Intestine Large, Rectum                            (49)         (18)         (49)                                                
      Parasite Metazoan                                2 (4%)                    2 (4%)                                             
   Intestine Small, Duodenum                          (50)         (23)         (49)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   2 (4%)       2 (4%)                                             
      Basophilic Focus                                37 (74%)     27 (54%)     25 (50%)                                            
      Clear Cell Focus                                15 (30%)     11 (22%)     19 (38%)                                            
      Congestion                                                    1 (2%)                                                          
      Degeneration, Cystic                             4 (8%)       1 (2%)       4 (8%)                                             
      Eosinophilic Focus                               7 (14%)      9 (18%)     10 (20%)                                            
      Fatty Change                                    41 (82%)     39 (78%)     49 (98%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                                    2 (4%)       1 (2%)                                             
      Hyperplasia                                                                3 (6%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic Active                    28 (56%)     23 (46%)     17 (34%)                                            
      Mixed Cell Focus                                 3 (6%)       4 (8%)       7 (14%)                                            
      Necrosis, Coagulative                            6 (12%)      6 (12%)      5 (10%)                                            
      Bile Duct, Hyperplasia                          35 (70%)     43 (86%)     32 (64%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Cytomegaly                                                  1 (2%)                                             
      Kupffer Cell, Hyperplasia                                     2 (4%)                                                          
   Mesentery                                          (4)          (5)          (3)                                                 
      Inflammation, Chronic Active                     1 (25%)      2 (40%)                                                         
      Necrosis, Coagulative                            1 (25%)      2 (40%)      1 (33%)                                            
   Pancreas                                           (50)         (27)         (50)                                                
      Atrophy                                          9 (18%)      2 (7%)      15 (30%)                                            
      Ectopic Tissue                                   1 (2%)                                                                       
      Hyperplasia                                      8 (16%)      3 (11%)      6 (12%)                                            
      Inflammation, Chronic                            8 (16%)      1 (4%)       6 (12%)                                            
      Inflammation, Chronic Active                                  1 (4%)                                                          
      Pigmentation                                     2 (4%)                                                                       
      Acinus, Hyperplasia                              1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
   Salivary Glands                                    (49)         (23)         (49)                                                
      Atrophy                                                                    1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Chronic                            2 (4%)       1 (4%)       1 (2%)                                             
      Parotid Gland, Atrophy                                                     1 (2%)                                             
      Submandibular Gland, Atrophy                                               1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Acanthosis                                       4 (8%)       8 (16%)      7 (14%)                                            
      Hyperkeratosis                                   3 (6%)       8 (16%)      7 (14%)                                            
      Hyperplasia, Basal Cell                          4 (8%)       9 (18%)      2 (4%)                                             
      Hyperplasia, Pseudoepitheliomatous                            1 (2%)                                                          
      Inflammation, Chronic Active                                  3 (6%)       2 (4%)                                             
      Ulcer                                                         5 (10%)      6 (12%)                                            
      Muscularis, Mineralization                       1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (49)                                                
      Erosion                                                       1 (2%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               6 (12%)                                            
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
      Arteriole, Mineralization                        1 (2%)                                                                       
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Mucosa, Mineralization                                        1 (2%)                                                          
      Mucosa, Necrosis                                              1 (2%)                                                          
      Muscularis, Mineralization                       2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (20)         (50)                                                
      Cardiomyopathy                                  48 (96%)     18 (90%)     48 (96%)                                            
      Atrioventricular Valve, Mineralization, Focal    1 (2%)                                                                       
      Atrium, Congestion                                                         1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)       1 (5%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Angiectasis                                     29 (58%)     19 (39%)     18 (36%)                                            
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
      Hyperplasia                                      7 (14%)      6 (12%)      9 (18%)                                            
      Vacuolization Cytoplasmic                       32 (64%)     26 (53%)     32 (64%)                                            
   Adrenal Gland, Medulla                             (50)         (48)         (49)                                                
      Angiectasis                                     34 (68%)     23 (48%)     23 (47%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                     11 (22%)     15 (31%)     12 (24%)                                            
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       2 (4%)                                                                       
   Islets, Pancreatic                                 (50)         (22)         (50)                                                
      Hyperplasia                                      2 (4%)                    2 (4%)                                             
   Pituitary Gland                                    (48)         (26)         (47)                                                
      Pars Distalis, Angiectasis                       4 (8%)       1 (4%)       1 (2%)                                             
      Pars Distalis, Cyst                              2 (4%)       1 (4%)       2 (4%)                                             
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      22 (46%)      8 (31%)     26 (55%)                                            
      Pars Distalis, Necrosis, Coagulative             1 (2%)                                                                       
      Pars Distalis, Pigmentation                                   2 (8%)                                                          
      Pars Intermedia, Angiectasis                     2 (4%)                    1 (2%)                                             
      Pars Intermedia, Cyst                            1 (2%)                    1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Intermedia, Pigmentation                                 1 (4%)                                                          
   Thyroid Gland                                      (49)         (21)         (49)                                                
      C-Cell, Hyperplasia                             22 (45%)      3 (14%)     17 (35%)                                            
      Follicle, Cyst                                   1 (2%)                    1 (2%)                                             
      Follicle, Mineralization                         1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Epithelium, Hyperplasia                         16 (32%)     26 (53%)     26 (52%)                                            
   Preputial Gland                                    (43)         (25)         (47)                                                
      Abscess                                                       1 (4%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                           16 (37%)      7 (28%)      7 (15%)                                            
      Inflammation, Chronic Active                    22 (51%)     12 (48%)     36 (77%)                                            
   Prostate                                           (50)         (21)         (46)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Inflammation, Acute                              5 (10%)      3 (14%)      9 (20%)                                            
      Inflammation, Chronic                                                      4 (9%)                                             
      Inflammation, Chronic Active                    19 (38%)      5 (24%)     10 (22%)                                            
      Epithelium, Hyperplasia                          4 (8%)                                                                       
   Seminal Vesicle                                    (49)         (36)         (47)                                                
      Atrophy                                         17 (35%)     14 (39%)     23 (49%)                                            
      Inflammation, Acute                                           1 (3%)                                                          
   Testes                                             (50)         (49)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Arteriole, Inflammation, Chronic Active          2 (4%)                                                                       
      Arteriole, Necrosis, Fibrinoid                   1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  35 (70%)     14 (29%)     29 (58%)                                            
      Seminiferous Tubule, Atrophy                    44 (88%)     41 (84%)     45 (90%)                                            
      Seminiferous Tubule, Mineralization              5 (10%)     26 (53%)     14 (28%)                                            
      Seminiferous Tubule, Necrosis, Coagulative       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (26)         (50)                                                
      Mediastinal, Angiectasis                         2 (4%)                                                                       
      Mediastinal, Depletion Lymphoid                               1 (4%)       1 (2%)                                             
      Mediastinal, Ectasia                             1 (2%)       1 (4%)                                                          
      Mediastinal, Hemorrhage                          8 (16%)      1 (4%)       7 (14%)                                            
      Mediastinal, Hyperplasia                         1 (2%)                                                                       
      Mediastinal, Inflammation, Chronic Active                     1 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Pigmentation                        3 (6%)       2 (8%)       3 (6%)                                             
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Pancreatic, Fibrosis                             1 (2%)                                                                       
      Pancreatic, Hemorrhage                                        1 (4%)                                                          
      Pancreatic, Infiltration Cellular, Histiocyte                 1 (4%)                                                          
      Pancreatic, Pigmentation                         1 (2%)                                                                       
      Renal, Hemorrhage                                             1 (4%)                                                          
      Renal, Pigmentation                              1 (2%)       1 (4%)                                                          
   Lymph Node, Mandibular                             (44)         (18)         (41)                                                
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)                    1 (2%)                                             
      Ectasia                                         10 (23%)      1 (6%)       2 (5%)                                             
      Hematocyst                                                                 1 (2%)                                             
      Hemorrhage                                       5 (11%)      3 (17%)      5 (12%)                                            
      Hyperplasia                                      7 (16%)      1 (6%)       2 (5%)                                             
      Infiltration Cellular, Histiocyte                                          3 (7%)                                             
      Pigmentation                                                               2 (5%)                                             
   Lymph Node, Mesenteric                             (47)         (19)         (49)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (5%)       5 (10%)                                            
      Infiltration Cellular, Histiocyte               30 (64%)      3 (16%)     35 (71%)                                            
      Pigmentation                                    34 (72%)      4 (21%)     32 (65%)                                            
   Spleen                                             (50)         (32)         (50)                                                
      Congestion                                       2 (4%)       1 (3%)       1 (2%)                                             
      Depletion Lymphoid                               6 (12%)     13 (41%)      9 (18%)                                            
      Fibrosis                                         2 (4%)       2 (6%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       1 (3%)       3 (6%)                                             
      Hyperplasia, Reticulum Cell                                                4 (8%)                                             
      Necrosis, Coagulative, Focal                     1 (2%)                                                                       
      Pigmentation                                                  1 (3%)                                                          
      Capsule, Inflammation, Chronic Active,                                                                                        
          Necrotizing                                               1 (3%)                                                          
   Thymus                                             (42)         (18)         (42)                                                
      Congestion                                                    1 (6%)                                                          
      Cyst                                             2 (5%)                    1 (2%)                                             
      Depletion Lymphoid                              37 (88%)     13 (72%)     38 (90%)                                            
      Hemorrhage                                       1 (2%)       2 (11%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (21)         (8)          (24)                                                
      Galactocele                                                   1 (13%)                                                         
      Hyperplasia                                     10 (48%)      3 (38%)     19 (79%)                                            
      Pigmentation                                     1 (5%)                                                                       
   Skin                                               (50)         (27)         (49)                                                
      Acanthosis                                       1 (2%)       2 (7%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Atrophy                                          1 (2%)                                                                       
      Cyst Epithelial Inclusion                        2 (4%)                    1 (2%)                                             
      Hyperkeratosis                                   1 (2%)       1 (4%)       2 (4%)                                             
      Hyperplasia, Basal Cell                          1 (2%)                    2 (4%)                                             
      Hyperplasia, Pseudoepitheliomatous                            1 (4%)                                                          
      Inflammation, Acute, Hemorrhagic                              1 (4%)                                                          
      Inflammation, Acute, Necrotizing                              1 (4%)                                                          
      Inflammation, Chronic Active                                  1 (4%)       1 (2%)                                             
      Inflammation, Chronic Active, Necrotizing        2 (4%)                                                                       
      Ulcer                                                                      1 (2%)                                             
      Subcutaneous Tissue, Fibrosis                    2 (4%)       1 (4%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (21)         (50)                                                
      Autolysis                                                     1 (5%)                                                          
   Skeletal Muscle                                    (1)          (3)          (1)                                                 
      Hemorrhage                                                    1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (20)         (50)                                                
      Mineralization, Multifocal                       1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
      Meninges, Hemorrhage                             1 (2%)                    1 (2%)                                             
      Thalamus, Mineralization                                                   1 (2%)                                             
      Third Ventricle, Hemorrhage                                   1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (34)         (50)                                                
      Congestion                                       2 (4%)      10 (29%)      4 (8%)                                             
      Crystals                                                      1 (3%)       1 (2%)                                             
      Edema                                                         2 (6%)       1 (2%)                                             
      Fibrosis                                         2 (4%)       1 (3%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Granuloma                                        1 (2%)       1 (3%)       2 (4%)                                             
      Hemorrhage                                       2 (4%)       2 (6%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte               13 (26%)     13 (38%)     12 (24%)                                            
      Inflammation, Chronic                           11 (22%)      4 (12%)      2 (4%)                                             
      Inflammation, Chronic Active                     7 (14%)      3 (9%)       6 (12%)                                            
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Pigmentation                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 7 (14%)      3 (9%)       5 (10%)                                            
      Artery, Hyperplasia                              2 (4%)       1 (3%)       1 (2%)                                             
      Artery, Mineralization                          21 (42%)     16 (47%)     24 (48%)                                            
      Bronchiole, Epithelium, Hyperplasia              1 (2%)                    1 (2%)                                             
      Bronchus, Bronchiectasis                                      1 (3%)                                                          
   Nose                                               (49)         (19)         (49)                                                
      Edema                                                         2 (11%)                                                         
      Hemorrhage                                       2 (4%)       1 (5%)       2 (4%)                                             
      Inflammation, Acute                             11 (22%)                   5 (10%)                                            
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active                     4 (8%)       1 (5%)       2 (4%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)       3 (16%)      2 (4%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                    1 (5%)                                                          
      Nasolacrimal Duct, Metaplasia, Squamous                       2 (11%)      4 (8%)                                             
      Nasopharyngeal Duct, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
   Trachea                                            (50)         (21)         (50)                                                
      Inflammation, Acute, Necrotizing                                           1 (2%)                                             
      Peritracheal Tissue, Hemorrhage                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)          (1)                                                              
      Inflammation, Chronic Active                     1 (33%)      1 (100%)                                                        
   Eye                                                (1)                       (3)                                                 
      Cataract                                                                   1 (33%)                                            
      Retina, Degeneration                                                       1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Congestion                                       3 (6%)                    8 (16%)                                            
      Cyst                                             2 (4%)                    2 (4%)                                             
      Metaplasia, Osseous                                           1 (2%)                                                          
      Nephropathy                                     49 (98%)     49 (100%)    50 (100%)                                           
      Collecting Tubule, Mineralization                5 (10%)     10 (20%)     35 (70%)                                            
      Papilla, Necrosis                                1 (2%)      10 (20%)     24 (48%)                                            
      Papilla, Necrosis, Coagulative                                             1 (2%)                                             
      Pelvis, Dilatation                               1 (2%)       1 (2%)       1 (2%)                                             
      Pelvis, Mineralization                           1 (2%)                                                                       
      Pelvis, Epithelium, Hyperplasia                 14 (28%)      7 (14%)     12 (24%)                                            
      Proximal Convoluted Renal Tubule,                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05063-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 19:05:34  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.05G/KG     0.1 G/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
          Inflammation, Acute                          6 (12%)     13 (27%)     27 (54%)                                            
      Proximal Convoluted Renal Tubule,                                                                                             
          Mineralization                               1 (2%)       1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Pigmentation                                 2 (4%)       1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        3 (6%)       1 (2%)       3 (6%)                                             
      Renal Tubule, Hyperplasia, Focal                                           1 (2%)                                             
   Urethra                                            (1)          (1)          (1)                                                 
      Calculus Micro Observation Only                  1 (100%)     1 (100%)     1 (100%)                                           
   Urinary Bladder                                    (45)         (22)         (48)                                                
      Calculus Micro Observation Only                               1 (5%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)       1 (5%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.