National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2300

TDMS Study 05063-01 Pathology Tables

NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97
Route: GAVAGE                                                                                                     Time: 07:53:22




       Facility:  TSI Mason Research

       Chemical CAS #:  50-33-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Parasite Metazoan                    |                                              1                 1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Parasite Metazoan                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1  1     1  1  1  2     2  1  1  2  1  1  2  3  1  2        1  2  1  1   |             
      Clear Cell Focus                     |             2  1     1        1                                          |             
      Fatty Change                         |          2        1     2  2     2        2  1           2  1  2        2|             
      Hemorrhage                           |                            1                                             |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                              3                 2         |             
      Inflammation, Chronic Active         | 1        2     1  1           1  2           1  1  1           1  2      |             
      Mixed Cell Focus                     |                1                                               2         |             
      Necrosis, Coagulative                |                                              1           1               |             
      Pigmentation                         |          1                                                               |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1           1  1     1     1        1     1  2  1  1  1  1  1        1   |             
      Kupffer Cell, Hyperplasia, Focal     |                                                             1            |             
      Periportal, Fibrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +                              |             
      Fibrosis                             |                                           2                              |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Necrosis, Coagulative                |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2     1  1                          1     1        1  1      |             
      Fibrosis, Focal                      |                                                    1                     |             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Chronic                |       1        1                                1  1           1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                          2               |             
      Hyperkeratosis                       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                          2               |             
      Inflammation, Granulomatous          |                                                                          |             
      Ulcer                                |                                                                          |             
      Ulcer, Multiple                      |                                                                          |             
      Submucosa, Foreign Body              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  1  2     2  2  2  1  1  1        1  1  1        1  1  1      |             
      Atrium, Embolus                      |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     1  1  1  1              2  2  1  2     2  1        1     2  2   |             
      Atrophy                              |                                                                         4|             
      Autolysis                            |                         3                                                |             
      Congestion                           |                                                                          |             
      Degeneration                         |                                                                         3|             
      Hyperplasia                          |       1                                   1                              |             
      Mineralization                       |                   1                                                      |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                         2|             
      Vacuolization Cytoplasmic            |    1  2  1  1     4        2  1     1     1  1  2     2        1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                         3                                                |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2  4        4  2  3     3  4  2  4  3  2           2        4  4  1  1  3|             
      Pars Distalis, Cyst                  | 2           2  2  3        4           2  1     1  2  1           1  1   |             
      Pars Distalis, Hyperplasia           | 2        1                 3  1           1        1  2                  |             
      Pars Distalis, Pigmentation          |                1        2                          1     2               |             
      Pars Intermedia, Angiectasis         |                                                                4         |             
      Pars Intermedia, Pigmentation        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Nervosa, Angiectasis            |                                     3              2                     |             
      Pars Nervosa, Cyst                   |          2                                                               |             
      Pars Nervosa, Pigmentation           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  | 1     1  1  1  1  1        1  1        1           1  1  1           1   |             
      Follicular Cell, Hyperplasia         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  M  M  +  +|             
      Inflammation, Chronic                |                   1                                                      |             
      Inflammation, Chronic Active         |             3                    2  1     3     2  2                 2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                        2                                 |             
      Mineralization                       |                                                                          |             
      Corpus Luteum, Cyst                  |                                                                          |             
      Periovarian Tissue, Cyst             |                      1                             3     1               |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           | 2           2     3                             2                       3|             
      Inflammation, Acute                  |                                                                         1|             
      Thrombosis                           |                                              3                           |             
      Endometrium, Hyperplasia             |                               1  1                                   1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                         1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                         1                                                |             
      Mediastinal, Hyperplasia             |                   3                                                      |             
      Mediastinal, Pigmentation            |                      1                       1  2  2                     |             
      Pancreatic, Depletion Lymphoid       |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                            2                                             |             
      Pancreatic, Pigmentation             |                            2                                             |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hemorrhage                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              | 2        1                 1                       1                     |             
      Hemorrhage                           | 1                                3     1                       3         |             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1     1     1  1  1  1  1  1  1  1     1     1  1  1   |             
      Pigmentation                         | 1  1  1  1  1  1  1     1     1  1  1  1  1  1  1  1     2     1  1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1  2                                                         |             
      Depletion Lymphoid                   |       4              4  2  4                 2        4  3              3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |                                                             3            |             
      Capsule, Fibrosis, Focal             |                      1                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 3        2        3     2        3     3  2     3  2              2  2  3|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    4        2  4  2                                                      |             
      Hyperplasia                          | 2  3  2  2  3  3  2  1  1  1  2  1     2  2     1  2  2  2  3     2  3   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Hydrocephalus                        |                                                             2            |             
      Cerebellum, Infarct                  |                                                                          |             
      Medulla, Infarct                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                1              2                                          |             
      Infiltration Cellular, Histiocyte    |                                                       1              1  2|             
      Inflammation, Acute, Necrotizing     |                      2                                                   |             
      Inflammation, Chronic                | 1              1  1              1        1     1              1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                     1              1                     |             
      Alveolar Epithelium, Hyperplasia     |    1              2                                1                    2|             
      Artery, Hyperplasia                  |                                                                          |             
      Artery, Mineralization               |    1                                   1     1     1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          1                                         3                     |             
      Inflammation, Chronic Active         |                                  1           1                 1         |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |             1                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     I                 I                  |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  1  1  1  1  1  1           1  1  1  1  1  1     1        1  2  1  2  2|             
      Pigmentation                         |                                                                          |             
      Collecting Tubule, Mineralization    |             1        1                                                   |             
      Distal Convoluted Renal Tubule,      |                                                                          |             
          Mineralization                   |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Pelvis, Epithelium, Mineralization   |          1                 1                                1        1   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                               2              2     2                    2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|             
                                           | 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +|  48        |
      Parasite Metazoan                    |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | 1                    1  1  1     2     1     2                           |      9  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      1   |      1  1.0|
      Basophilic Focus                     | 2     X  1  2        2  2  1  1  1     1        2  3  1        1        1|     35  1.4|
      Clear Cell Focus                     |                                                                          |      4  1.3|
      Fatty Change                         |    3        2  2  3                       3  2     2        4        2   |     20  2.1|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Chronic Active         | 2        1  1                       2  1                       1         |     17  1.3|
      Mixed Cell Focus                     |                                                                          |      2  1.5|
      Necrosis, Coagulative                |    1     1                                2              1               |      6  1.2|
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                       2                  |      1  2.0|
      Bile Duct, Hyperplasia               |    2  1  1     2     1  1  1  1              1     1  2  1  1           1|     28  1.1|
      Kupffer Cell, Hyperplasia, Focal     |                                                                          |      1  1.0|
      Periportal, Fibrosis                 |                2                                      1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1     1                          1           1                     |     11  1.1|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |       1     1           1  1           1                       1        1|     12  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |    2                             2                 2                     |      4  2.0|
      Hyperkeratosis                       |                                  2                 2                     |      3  2.0|
      Hyperplasia, Basal Cell              |    2                             2                 2                     |      4  2.0|
      Inflammation, Granulomatous          |                                  2                                       |      1  2.0|
      Ulcer                                |                                                    2                     |      1  2.0|
      Ulcer, Multiple                      |                                                                   2      |      1  2.0|
      Submucosa, Foreign Body              |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                2                                            2            |      2  2.0|
      Inflammation, Chronic                |                                                             1            |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +                 +                                                |   2        |
      Aorta, Inflammation, Chronic Active  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2     1  1     2  1  1     1     1  2  1  1  2  1  1  1     2        1|     35  1.3|
      Atrium, Embolus                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2     2  2  1     1  1  2     2  2  1  2        1        1     1        1|     30  1.5|
      Atrophy                              |                                                                          |      1  4.0|
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                   2      |      1  2.0|
      Degeneration                         |                                                                          |      1  3.0|
      Hyperplasia                          |       1              2  1                          2                    2|      7  1.4|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis, Coagulative                |    1                                                                     |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1  3  1              1  1           1  1           2     2  3           1|     24  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          | 1              2                                               1         |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis, Focal                   |       1                                                                  |      1  1.0|
      Hyperplasia                          |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +  M  +  +  +  +  A  M  +  +  +  +  +  M  +  M  M  +  M  M  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           | 4  1  2  2  1        3  2  2  2  2  3  2     2  4     1  2  2  3        4|     36  2.6|
      Pars Distalis, Cyst                  |    1     2              2     2     1  1     1     3        2  4     1   |     23  1.8|
      Pars Distalis, Hyperplasia           |    1                                               1  2                  |     10  1.5|
      Pars Distalis, Pigmentation          |    1     1           1     2  1              1              1           1|     12  1.3|
      Pars Intermedia, Angiectasis         |                                     3                                    |      2  3.5|
      Pars Intermedia, Pigmentation        |    1                          1                                          |      2  1.0|
      Pars Nervosa, Angiectasis            |                                                                          |      2  2.5|
      Pars Nervosa, Cyst                   |                                                                          |      1  2.0|
      Pars Nervosa, Pigmentation           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     3                                    |      1  3.0|
      C-Cell, Hyperplasia                  | 2     1     1     1  1     1        1  1        1  1                    1|     24  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  M  M  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +     +  +|  36        |
      Inflammation, Chronic                |          1  1              2        1           1           1  1         |      8  1.1|
      Inflammation, Chronic Active         | 2     1              1                 2                                1|     12  1.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               1                                          |      1  1.0|
      Cyst                                 | 2                                                        2               |      3  2.0|
      Mineralization                       |                                     1                                   1|      2  1.0|
      Corpus Luteum, Cyst                  |                                        2                                 |      1  2.0|
      Periovarian Tissue, Cyst             |                      2                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                +         |   1        |
      Inflammation, Chronic                |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                               2                                          |      6  2.3|
      Inflammation, Acute                  |                                                 1                        |      2  1.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             |    2                 3                 1        2  1        2            |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hemorrhage              |                                     3        2                           |      3  2.0|
      Mediastinal, Hyperplasia             |             2                                                            |      2  2.5|
      Mediastinal, Pigmentation            |                                                                          |      4  1.5|
      Pancreatic, Depletion Lymphoid       |                                                       2                  |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                 1     2                  |      3  1.7|
      Renal, Angiectasis                   |                                                       3                  |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  M  M  M  +|  42        |
      Angiectasis                          |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      4  1.3|
      Hemorrhage                           |             3           1                                                |      6  2.0|
      Hyperplasia                          |          2                                                               |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      1                                                   |      2  1.5|
      Infiltration Cellular, Histiocyte    | 1     1  1  2        1  1  2  1     1  1        1  1        1  1        1|     35  1.1|
      Pigmentation                         | 1     1     1        1  1  1  1     1  1        1  1        1  1        1|     34  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  1.5|
      Depletion Lymphoid                   |    4           3                          2  2        2     3            |     14  3.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      1  2.0|
      Pigmentation                         |                                                       2  2           2   |      4  2.3|
      Capsule, Fibrosis, Focal             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  42        |
      Depletion Lymphoid                   | 3  4  2  3  3     3           4  2  3  4  2     3  3  4  4  4            |     28  2.9|
      Hemorrhage                           |                                  2           2                           |      2  2.0|
      Necrosis                             |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Galactocele                          |                                                                          |      4  3.0|
      Hyperplasia                          | 2  2     2  2  2  2  2  2  2  1     2  2  1     3  2  2  2  2  2        4|     41  2.0|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           4                              |      2  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Cerebellum, Infarct                  |    1                                      4                              |      2  2.5|
      Medulla, Infarct                     |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  3                                       |      1  3.0|
      Hemorrhage                           |    1           1                                                         |      4  1.3|
      Infiltration Cellular, Histiocyte    |       1        1           1                 1                 1     1   |      9  1.1|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  2.0|
      Inflammation, Chronic                |             1                 1                 1                        |     11  1.0|
      Inflammation, Chronic Active         | 1        1           1                 2                    1  2        1|      9  1.2|
      Alveolar Epithelium, Hyperplasia     | 1     1        1                                            2  1         |      9  1.3|
      Artery, Hyperplasia                  |                                                       2                  |      1  2.0|
      Artery, Mineralization               |             1  1  1     1  1  1     1  1  1        1  1     1  1        1|     18  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
      Inflammation, Acute                  |                                        1           1                     |      4  1.5|
      Inflammation, Chronic Active         |       2     2                                                            |      5  1.4|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                              1                           |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +  +                                                         |   3        |
      Cataract                             |       3                                                                  |      1  3.0|
      Retina, Degeneration                 |       4                                                                  |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3|            |
                                           | 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Sclera, Metaplasia, Osseous          |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   2        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    2                     |      1  2.0|
      Cyst                                 |       4                                                                  |      1  4.0|
      Nephropathy                          | 2  2  2  1  1        2  2  2  1  1  2  3        2  2  3  1  2  1        2|     38  1.5|
      Pigmentation                         |                                                    2  2                  |      2  2.0|
      Collecting Tubule, Mineralization    |    1                                                                     |      3  1.0|
      Distal Convoluted Renal Tubule,      |                                                                          |            |
          Mineralization                   |                                                                1         |      1  1.0|
      Pelvis, Dilatation                   |                                                       4                  |      1  4.0|
      Pelvis, Epithelium, Hyperplasia      | 1  2                    1     1                    1  3     2            |      7  1.6|
      Pelvis, Epithelium, Mineralization   | 1  1                 1  1  1  1                 1           1        1   |     13  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |                      1                                                  1|      2  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |                                                                   1      |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                                                          |      4  2.0|
      Renal Tubule, Hyperplasia            |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                       X                  |      1     |
      Inflammation, Chronic                |                                     1                                    |      1  1.0|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
      Metaplasia, Squamous                 |                                                       1                  |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                       3                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|             
                                           | 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                          +                                 |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        +  +     +  +  +        +              +      |             
      Angiectasis                          |                                     3              1                     |             
      Basophilic Focus                     |             1              1  1     1              X              1      |             
      Clear Cell Focus                     |             2                                                            |             
      Eosinophilic Focus                   |    3     2        2        3                                             |             
      Fatty Change                         |       1        2  2           1                                          |             
      Hepatodiaphragmatic Nodule           |       X     X                                                            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    1  1        1  2        1  1                    2              1      |             
      Necrosis, Coagulative                |                1              1           3                              |             
      Bile Duct, Hyperplasia               |    1        2  2           1  1                                          |             
      Periportal, Fibrosis                 |             1                                                            |             
      Serosa, Inflammation, Chronic, Focal |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +                    +         |             
      Fibrosis                             |                                  2                             3         |             
      Hemorrhage                           |                                                                2         |             
      Mineralization                       |                                                                1         |             
      Necrosis, Coagulative                |                                  3                             3         |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                          +  +                              |             
      Atrophy                              |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Ulcer                                |                                        2                                 |             
      Muscularis, Mineralization           |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
      Fibrosis                             |                                           3                              |             
      Muscularis, Mineralization           |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                          +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|             
                                           | 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |             2                          1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1     2  2  2  1  2  1  1  1  1  1     2              1  1        1|             
      Atrophy                              |                                                 4                        |             
      Autolysis                            |          3                                                               |             
      Hyperplasia                          | 1  2              2     1        1                 1                    1|             
      Necrosis, Coagulative                |                                        1        4                        |             
      Vacuolization Cytoplasmic            | 1     2        1  2     1  1  1           2  1  3     1  1  1  1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Autolysis                            |          3                                                               |             
      Hyperplasia                          |                   1     1        1                          1        1   |             
      Necrosis, Coagulative                |                                           3     4                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +        +  +     +  +     M  +  +     +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  2        2  2  4  3        3     3              3  2     3  4     3  3|             
      Pars Distalis, Cyst                  | 2                       1  1     1  2  1     3  1  4  2  3        3      |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |             3                                   1                 2      |             
      Pars Distalis, Pigmentation          |                                           2                              |             
      Pars Intermedia, Angiectasis         |                                     3                 2                  |             
      Pars Intermedia, Cyst                | 1     2                 1                    3                           |             
      Pars Nervosa, Angiectasis            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1  1  1     1  1  1        1  1  1  1  1  1  1  1  1  2  1|             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +        +                 M           +           +         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                      4                                         3         |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +     +     +                    +                          +      |             
      Atrophy                              |       3                                                                  |             
      Cyst                                 |    X                                                                     |             
      Periovarian Tissue, Cyst             |                   X                                               4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|             
                                           | 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +     +     +  +  +  +     +     +                           |             
      Hydrometra                           |                                        2                                 |             
      Endometrium, Hyperplasia             |                               4              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                          M                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +        +  +     +  +                     |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                 3                        |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                          M        +  +                     |             
      Hemorrhage                           |                                                 4  2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                 +        +  +                              |             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                               1                                          |             
      Pigmentation                         |                               1                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1                                                                        |             
      Depletion Lymphoid                   |          3                          2  2  3           2        2         |             
      Pigmentation                         |             2                          3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                          +                                 |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |             3                          3                                 |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        M     +  +        +        M                    +  +     +   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                      3                                      3  2         |             
                                            __________________________________________________________________________|             
   Skin                                    |             +        +        +        +                             +   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Granulomatous   |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                          +                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +     +                    +  +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +           +  +           +  +     +        +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|             
                                           | 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                        2                                 |             
      Hemorrhage                           |                                        2                                 |             
      Infiltration Cellular, Histiocyte    |                         1                                                |             
      Inflammation, Chronic Active         |                            2                             1               |             
      Alveolar Epithelium, Hyperplasia     |                            2                                             |             
      Artery, Mineralization               |          1                             1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                          +                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       1                                                                  |             
      Inflammation, Acute, Necrotizing     |          3                                                               |             
      Nephropathy                          | 2  1  1     2  2  3  3  2  2  3  2  3  1  2  2  3  2  2  2  3  3  2  2  1|             
      Collecting Tubule, Mineralization    | 1     1        1  1  1  1     1  1  1  1  1  1     1  2        1        2|             
      Papilla, Mineralization              |                                                                          |             
      Papilla, Necrosis                    | 1     2        1  1  1  1     1                       1        2         |             
      Pelvis, Epithelium, Hyperplasia      | 1  1        1        1           1  2     2     2     2                 1|             
      Pelvis, Epithelium, Mineralization   |                                                 2                 1  1  2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                 2        2              1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |          4                                                               |             
      Inflammation, Chronic                |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3|            |
                                           | 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  M  +  +     +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +     +                 +                    +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +     A                 +                                       |   5        |
      Parasite Metazoan                    |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +     +                 +                    +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +     +                 +                    M                  |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +  +              +                    +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +     +  +              +                    +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +     +                 +                    +     +            |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     M                 +                    +     +            |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +           +     +  +  +              +  +     +     +   |  27        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |       2     2              2     1  1                    1     2     1   |     14  1.3|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                     1                                    |      5  2.2|
      Fatty Change                         |    3  1                    1        1  1                 2           2   |     11  1.5|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      3     |
      Hyperplasia                          |                                                                2         |      1  2.0|
      Inflammation, Chronic Active         |       1     3                                                        1   |     11  1.4|
      Necrosis, Coagulative                |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               |          2                 1        1                                    |      8  1.4|
      Periportal, Fibrosis                 |                                                                          |      1  1.0|
      Serosa, Inflammation, Chronic, Focal |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                         +         |   5        |
      Fibrosis                             |                                                                3         |      3  2.7|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                3         |      2  2.0|
      Necrosis, Coagulative                |                                                                4         |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +     +                 +                    +     +            |   9        |
      Atrophy                              |          2                       1                                       |      3  1.7|
      Inflammation, Chronic                |          1                       1                                       |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +     +                 +                    +                  |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Basal Cell              |                                                    1                     |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
      Muscularis, Mineralization           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3|            |
                                           | 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  3.0|
      Muscularis, Mineralization           |                                                             1            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +     +                 +                    +                  |   7        |
      Cardiomyopathy                       |          1                       1                                       |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         1     1        1  1  1  2        2  2  1     2   |     26  1.3|
      Atrophy                              |                                                                          |      1  4.0|
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          |                      1                    2  2  2           2            |     12  1.5|
      Necrosis, Coagulative                |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |       2  1        1  1     1  1  2        1  1           1  1     1     1|     27  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         1|      1  1.0|
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia                          | 2                                                                        |      6  1.2|
      Necrosis, Coagulative                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +     +                 +                    +                  |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M     +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                   4  4                             4              4     3|     19  3.1|
      Pars Distalis, Cyst                  | 2           3     2     1  2  1     1  2  2     2              1  X  1  1|     26  1.8|
      Pars Distalis, Hemorrhage            |       4                                                                  |      1  4.0|
      Pars Distalis, Hyperplasia           | 3                                2                       3               |      6  2.3|
      Pars Distalis, Pigmentation          |                      1                                                   |      2  1.5|
      Pars Intermedia, Angiectasis         |                                                                          |      2  2.5|
      Pars Intermedia, Cyst                |                                                                          |      4  1.8|
      Pars Nervosa, Angiectasis            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2                 2  2           1        1     1                 1  1  1|     26  1.2|
      Follicular Cell, Cyst                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3|            |
                                           | 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +     M     +                 M  +  +                       +         |  11        |
      Inflammation, Acute                  |                                     4                                    |      1  4.0|
      Inflammation, Chronic Active         |                                        1                                 |      1  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      | 4                                                              4         |      4  3.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +           +     +                 +  +                  |  14        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |    2                                                                     |      2  2.0|
      Periovarian Tissue, Cyst             | 4                                                  2                     |      4  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +     +     +  +  +     +                    +           +      |  17        |
      Hydrometra                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                  2                                       |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +     +                 +                    +                  |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +     +     +     +     +                    +           +      |  15        |
      Mediastinal, Depletion Lymphoid      |    4                                                                     |      1  4.0|
      Mediastinal, Ectasia                 |          2                                                               |      1  2.0|
      Mediastinal, Hemorrhage              |       3                                               3                  |      3  3.0|
      Renal, Hyperplasia                   |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     M     +                 M                    M                  |   5        |
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +     +     +     +     +                    +           +      |  13        |
      Depletion Lymphoid                   |    2                                                                     |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1              1     1                                      1      |      5  1.0|
      Pigmentation                         |    1  1  2           1     1                                      1      |      7  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  1.0|
      Depletion Lymphoid                   |    3  3  4           4     4  4  2                                      2|     14  2.9|
      Pigmentation                         |    3           3           2                                             |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +     +                 +                    +                  |   8        |
      Congestion                           |    3                                                                     |      1  3.0|
      Depletion Lymphoid                   |    4  3  3                       2                                       |      6  3.0|
      Hemorrhage                           |    2                                                  3                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     M     M  +  +     +     +  +                 M  +  +        +  +|  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3|            |
                                           | 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          |                                  X                                       |      1     |
      Hyperplasia                          | 2                                   2                                    |      5  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +     +     +           +                    +                 +|  12        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Granulomatous   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +     +                 +                    +                  |   7        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +     +                 +                    +                  |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +     +  +  +           +  +     +  +        +  +        +      |  20        |
      Congestion                           |                3                                      3                  |      3  2.7|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          3     1  1                          1                    1      |      6  1.3|
      Inflammation, Chronic Active         |                2     1                                                   |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Mineralization               |          1           1                                                   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +     +                 +                                       |   6        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |          2                                                               |      1  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            3                                             |      2  2.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
      Nephropathy                          | 2  2  3  3  2  1  1  3  2  3     1  3  1  2  3  2  3  1  3     1  3     1|     46  2.1|
      Collecting Tubule, Mineralization    |    1  1     1        1  1     1  1  1  1     1  1  1     1  1  1         |     31  1.1|
      Papilla, Mineralization              |                            3                                             |      1  3.0|
      Papilla, Necrosis                    |             2  1        1  2        1  1     1        1        1         |     18  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3|            |
                                           | 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Epithelium, Hyperplasia      |                      2  1  3              1     1  2     2  2  1     1   |     20  1.5|
      Pelvis, Epithelium, Mineralization   | 1                 1  1                          1        1  1        1   |     11  1.2|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |       1                                                                  |      4  1.5|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |          2                                                               |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  M  +  +  M  M  M  +  +  M  M  M  M  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Parasite Metazoan                    |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Parasite Metazoan                    |                                  1                       1               |             
      Mucosa, Fibrosis                     |                                     1                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Squamous          |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Chronic                     |                                                 4                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Muscularis, Inflammation, Acute      |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
      Serosa, Fibrosis                     |          1                                                               |             
      Serosa, Inflammation, Chronic        |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Depletion Cellular  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                  4                                       |             
      Ulcer                                |                                  4                                       |             
      Muscularis, Inflammation, Acute      |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                1         |             
      Basophilic Focus                     | 1  1  1  1  1     1  1     1  1  1  1     1        1  1  1     1  1     1|             
      Clear Cell Focus                     | 1                    1                             2                     |             
      Eosinophilic Focus                   |                                  1                       1               |             
      Fatty Change                         |       2     1           1        1     2     1  1           2        2   |             
      Focal Cellular Change                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                    X                                                |             
      Hyperplasia                          |                      2                                               4   |             
      Inflammation, Chronic Active         |                            1  2  1        1        2                     |             
      Necrosis, Coagulative                |       2        1                                                         |             
      Bile Duct, Hyperplasia               | 1        2     1           1  1  1  1     1     1  1  1  1     1  1  1  1|             
      Centrilobular, Cytomegaly            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Kupffer Cell, Hyperplasia, Focal     |                                                                          |             
      Periportal, Fibrosis                 |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                      2   |             
      Subserosa, Necrosis, Coagulative     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +                          +                 +  +   |             
      Fibrosis                             |          2           2                                                   |             
      Hemorrhage                           |                                                                      1   |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Mineralization                       |          1                                      2                 1      |             
      Necrosis, Coagulative                |          2           2                                            4  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1  2           1                       1  1              1   |             
      Inflammation, Chronic                |       1           1  3                       1                       1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2  2  2     2                          2                       3   |             
      Edema                                |                                        3                                 |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |       2  2  2     2                          3                       3   |             
      Hyperplasia, Basal Cell              |       2  2  2     2                          2                       3   |             
      Inflammation, Chronic Active         |                                              3                           |             
      Ulcer                                |       2  2  4     4                          4                       3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 4                        |             
      Edema                                |                                                                      2   |             
      Erosion                              |          2                                                               |             
      Inflammation, Chronic Active         | 1                                                           2        2  1|             
      Mineralization                       |                                                 3                        |             
      Ulcer                                |                            4                                   4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  2  2  2  1  2  2  2  2  2     2  2  3  2  2  1  2  1  1  1  1  1|             
      Mineralization                       |                                                 2                        |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1        1        1        1  1  1     1                 1     1     1|             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                   1        1     1                 2                    1|             
      Necrosis, Coagulative                |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            | 1     1     1     1  1     1     1  1  2  1  1  2  1     1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     1     1     1        1        1     1           1              1  1|             
      Thrombosis                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  M  M  M  M  M  M  M  M  M  +  +  +  M  M  +  +  M  M  M|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  1     4  2     2  4     2  2  3  4  2  1     2        3  3  1  4  4   |             
      Pars Distalis, Cyst                  | 2     1           1     1  2  1  1        2        1  1                 1|             
      Pars Distalis, Hyperplasia           |       1     1                    2        1        1  1        2         |             
      Pars Distalis, Pigmentation          |       1     1                                         2                  |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1           1  1     1     1     1        1  1  1  1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  M|             
      Inflammation, Acute                  |                         4                                                |             
      Inflammation, Chronic                |       1           1              1                                   1   |             
      Inflammation, Chronic Active         | 2        1  2              1  1        2  3  2           1  3  1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       1                             3                                    |             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |             3  1           2  1  2                 2                 1   |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Hyperplasia             |                            2                    2  2                    1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Mediastinal, Depletion Lymphoid      |                                              3                           |             
      Mediastinal, Hemorrhage              |       2     1                       1              1     1        3      |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                      2                                                   |             
      Renal, Ectasia                       |                                           2                              |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                           1                              |             
      Renal, Pigmentation                  |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  +  M  +  +  M  +  +  +  +  M  M  +  M  +  +  +  M  +  M  +  M|             
      Depletion Lymphoid                   |                                                                          |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                  2                 1  4        3     2   |             
      Hyperplasia                          | 2                 1              2                                   2   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |          2              2                                                |             
      Ectasia                              |                   2  2           4     2                                 |             
      Hemorrhage                           |       1                                1                                 |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1     1     1        1  1  1     1  1        1  1        1  1  1  1|             
      Pigmentation                         | 1     1     1     1        1  1  1     1  1        1  1        1  1  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |       2        2        2  2  2        1     4  1     3     3            |             
      Hematopoietic Cell Proliferation     |                   2                                         2        2   |             
      Pigmentation                         |                                                                          |             
      Subcapsular, Necrosis, Coagulative   |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Congestion                           |                3                                                         |             
      Cyst                                 |    2                                                                     |             
      Depletion Lymphoid                   |       2  3  3  2  4  2  3        2     2  3  4        2  2  2  3  3  4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Degeneration                         |                                                       2                  |             
      Galactocele                          |    2                                                                     |             
      Hyperplasia                          | 2     2  1  4     2     2  2  2  2  2  2  2  2     2     2  2     4  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                                   3      |             
      Granuloma                            |                                     2                                    |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1     1     1     1                 1           1           1|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic                |                            1              1  1     1  1                  |             
      Inflammation, Chronic Active         |                                  2                       1        2      |             
      Thrombosis, Multiple                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  2                       1               |             
      Artery, Mineralization               |       1  1     1  1     1  1  1        1  1     1     1           1  1   |             
      Bronchus, Mineralization             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                1                    2                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |             I                             I  I                           |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          4     4                                            4            |             
      Cyst                                 |    1  1     3     1              1  X     2  2                    1     2|             
      Inflammation, Acute, Necrotizing     |                4        4                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |          4                                                  4            |             
      Nephropathy                          | 4  3  4  4  4     4  4  3  4  2  3  3  4  4  4  4  3  2  3     4  4  4  4|             
      Pigmentation                         |                                                                          |             
      Collecting Tubule, Mineralization    | 3  2  2  2  2  1  2  1  3  2  2  3  2  3  3     4  2  2  4  2  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|             
                                           | 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilla, Angiectasis                 |                2           2                                   1         |             
      Papilla, Inflammation, Acute         |                                                                          |             
      Papilla, Necrosis, Coagulative       |          4              4                                   4            |             
      Papilla, Necrosis                    | 3  2  2     2  2  3  2     4  1  2  3  3  2     2  2  2  2     2  2  2  2|             
      Pelvis, Calculus Gross Observation   |                                                                          |             
      Pelvis, Dilatation                   | 2  1  1  4  2     2     3  2        1     2     2           2  2     2  2|             
      Pelvis, Epithelium, Hyperplasia      | 1  2     4  2  3  1  2     2     2  2     2     2  2  1  1  3  2  1  2  1|             
      Pelvis, Epithelium, Mineralization   |             2                                                        2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             | 1  2        1              1     1     1  1           2  1     1        1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                 4                        |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |          +                                                               |             
      Dilatation                           |          4                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Necrotizing                      |                2                                                         |             
      Inflammation, Chronic                |                         3                                                |             
      Inflammation, Chronic Active         |                2                                                         |             
      Transitional Epithelium, Hyperplasia |                2                                            3  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  M  +  M  +  M  +  +  M  +  +  +  M  +  +  M  +  M  +  +  +  M  +  M|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  49        |
      Depletion Lymphoid                   |                                                             2            |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                1                                                         |      1  1.0|
      Parasite Metazoan                    |             1  X           2           1                                 |      6  1.2|
      Mucosa, Fibrosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Metaplasia, Focal, Squamous          |                                                                      2   |      1  2.0|
      Parasite Metazoan                    |                   2                                                      |      1  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Chronic                     |                                                                          |      1  4.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |    4     4                                                               |      2  4.0|
      Epithelium, Hyperplasia              |          2                                                               |      1  2.0|
      Muscularis, Inflammation, Acute      |                                                             3            |      1  3.0|
      Muscularis, Mineralization           |                                                             2            |      1  2.0|
      Serosa, Fibrosis                     |                                                                          |      1  1.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Nodule, Depletion Cellular  |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
      Muscularis, Inflammation, Acute      |                                                             2            |      1  2.0|
      Muscularis, Mineralization           |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | 1     1     1     1     1  1     1  2     1     1     1     1        1   |     31  1.0|
      Clear Cell Focus                     |                                                                          |      3  1.3|
      Eosinophilic Focus                   |                                                                          |      2  1.0|
      Fatty Change                         |    1  1  2     2     2  1     2     1                    3        1      |     19  1.5|
      Focal Cellular Change                |                         2                                                |      1  2.0|
      Hemorrhage                           |       1                                                                  |      1  1.0|
      Hepatodiaphragmatic Nodule           |                         X                                                |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |             1     1     1  2           1                                 |     10  1.3|
      Necrosis, Coagulative                |                         1                                   1           4|      5  1.8|
      Bile Duct, Hyperplasia               | 2     1              1  1                       1        1           1   |     23  1.1|
      Centrilobular, Cytomegaly            |                                                                          |      1  3.0|
      Kupffer Cell, Hyperplasia, Focal     |                                                                      2   |      1  2.0|
      Periportal, Fibrosis                 | 2                                                                        |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Subserosa, Necrosis, Coagulative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                    +              +                 +  +            |  10        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |    4                    3                                2  2            |      5  2.6|
      Mineralization                       |                                                             2            |      4  1.5|
      Necrosis, Coagulative                |                                        3                                 |      5  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2  2        1                       1                             1|     11  1.3|
      Inflammation, Chronic                |          2                                         1                     |      7  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |    1     2                    2  2  2                                   2|     12  2.0|
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                          2               |      1  2.0|
      Hyperkeratosis                       |    1     2                    2  2  2                                   2|     12  2.1|
      Hyperplasia, Basal Cell              |    2     2                    2  2  2                                   2|     12  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |    2     2                    3  4  2                                   2|     12  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  4.0|
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                          2               |      2  2.0|
      Inflammation, Chronic Active         |    1                                                                     |      5  1.4|
      Mineralization                       |                                                 2           3           3|      4  2.8|
      Ulcer                                |                                              3                           |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1     2  2  1  2  1  1  2  2  2  1  1  2        1     2     2     2|     43  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                             4        2   |      3  2.7|
      Necrosis, Focal                      |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       1              1  1              1           1  2                  |     17  1.1|
      Degeneration, Fatty                  |                                     2                                    |      1  2.0|
      Hyperplasia                          |                            1              1                       2     1|      9  1.2|
      Necrosis, Coagulative                |                                                          2               |      2  3.0|
      Vacuolization Cytoplasmic            |    1  1  2              1              1  1  2        1  2  1     1  1  2|     31  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1           1                 1  1  1  1  1        1     1            |     19  1.1|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  M  M  M  +  M  M  M  +  M  M  M  +  M  M  M  M  +  M  M  +  M|  14        |
      Hyperplasia                          |                                                             4        2   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 3  2  3     2           1  2        2  1  2  3                       1  1|     30  2.3|
      Pars Distalis, Cyst                  |    1     1  1        3  2  2     1  1     2  1     1                    2|     23  1.4|
      Pars Distalis, Hyperplasia           |                1  1     2        2  2           1           1        1   |     15  1.3|
      Pars Distalis, Pigmentation          |                         1              1     1                           |      6  1.2|
      Pars Intermedia, Angiectasis         |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1        1           1  1     1  1     1  1  1                       1|     24  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M     M  +  +|  41        |
      Inflammation, Acute                  |                                  1                       2               |      3  2.3|
      Inflammation, Chronic                |                1           1                                             |      6  1.0|
      Inflammation, Chronic Active         |       1     2                             1     1     2              3   |     17  1.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                   1                                2                     |      9  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                      1                                                   |      1  1.0|
      Endometrium, Hyperplasia             |       2     2                                         3                  |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Myelofibrosis                        |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |    1        3              3              3                 2            |     11  1.9|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  1.0|
      Renal, Pigmentation                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +|  37        |
      Depletion Lymphoid                   |                                                                   2      |      1  2.0|
      Ectasia                              |       3                                                                  |      1  3.0|
      Hemorrhage                           |    2              2                                                      |      7  2.3|
      Hyperplasia                          |       1                                                                  |      5  1.6|
      Infiltration Cellular, Histiocyte    |                1                                                         |      1  1.0|
      Pigmentation                         |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Ectasia                              |    2                                                                     |      5  2.4|
      Hemorrhage                           |                                  1           2                           |      4  1.3|
      Hyperplasia                          |    2                                                                     |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1     1  1  1     1  1     1  1  1     1  1     1                 1|     28  1.0|
      Pigmentation                         | 1     1     1  1  1     1  1     1  1  1     1  1     1                 1|     29  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   | 3     3     2  1              2                          2        2  2  2|     19  2.2|
      Hematopoietic Cell Proliferation     |                                              2                           |      4  2.0|
      Pigmentation                         | 2                                                                        |      1  2.0|
      Subcapsular, Necrosis, Coagulative   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +|  38        |
      Congestion                           |                      2                                                   |      2  2.5|
      Cyst                                 |                                                    2                     |      2  2.0|
      Depletion Lymphoid                   |          2  2  3     4     3  3  3        2  2  3  2  3  3           3  3|     32  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  +  M  M  +  M|  40        |
      Degeneration                         |                                                                          |      1  2.0|
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |    3  2     3  2        3  2     1     2  2  3  2           2        1   |     32  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                             2            |      1  2.0|
      Hyperostosis                         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 1                                                                        |      2  2.0|
      Edema                                |                                                          3  2            |      2  2.5|
      Foreign Body                         |       1                                                     2     4      |      4  2.5|
      Granuloma                            |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   1     1  1     1  1  1  1  1           1  1           1|     22  1.0|
      Inflammation, Acute                  |                      4        1                                3         |      3  2.7|
      Inflammation, Acute, Necrotizing     |                                                                   4      |      1  4.0|
      Inflammation, Chronic                |                   1        1                          1                  |      8  1.0|
      Inflammation, Chronic Active         |       2        1                                1                        |      6  1.5|
      Thrombosis, Multiple                 |                                                                         1|      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Artery, Mineralization               | 1     1                          1     1     1              4            |     19  1.2|
      Bronchus, Mineralization             |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  49        |
      Inflammation, Acute                  |    2                 1  1                                                |      3  1.3|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  3.0|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |                                                                      2   |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                    1                     |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                              2                           |      1  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    I        I                                                            |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                               +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                          |      3  4.0|
      Cyst                                 |    1                             1        1     1                    2  1|     16  1.4|
      Inflammation, Acute, Necrotizing     |                                                                          |      2  4.0|
      Inflammation, Chronic Active         |          3                                                               |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      2  4.0|
      Nephropathy                          | 3  3  3  4  3  3  2  2  3  3  2  4  4  3  4  4  3  1  2  3  4     3  4  4|     47  3.3|
      Pigmentation                         |                                              2                           |      1  2.0|
      Collecting Tubule, Mineralization    | 3  3  1  4  1  3  2  1  2  2  2  3  3  2  2  2        2  2     1  2  3  2|     46  2.2|
      Papilla, Angiectasis                 |                                                                   2      |      4  1.8|
      Papilla, Inflammation, Acute         |                         2                 2                              |      2  2.0|
      Papilla, Necrosis, Coagulative       | 2                          2  1                                          |      6  2.8|
      Papilla, Necrosis                    |    3     2     2  2     2        2  2  2  2  2        2           2  4  2|     35  2.2|
      Pelvis, Calculus Gross Observation   |                                                          X               |      1     |
      Pelvis, Dilatation                   |                                  2        1  2              2     3  2  2|     22  2.0|
      Pelvis, Epithelium, Hyperplasia      |    2  1  2  2  2        1  1     2  1     2  2  2     2  3        2  2  2|     37  1.9|
      Pelvis, Epithelium, Mineralization   | 1     1                                                     2        3   |      6  1.8|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Hyperplasia                     |       1                                                                  |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             | 2     1  2  2           1  1  2     1  1     1  1     1     2     2     1|     26  1.3|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |                                                          2  4     2      |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7|            |
                             DAY ON TEST   | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2|            |
                                           | 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                                             2            |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Necrotizing                      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Submucosa, Hemorrhage                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       1                  |             
      Parasite Metazoan                    | 2  2              1  X     1                          X           1  1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                1     X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  1  1  1  1  1  1  1  1  1  1     2  1        1  1  1  1  1  2     1  1|             
      Clear Cell Focus                     |    1                 1     1        1  1                    1            |             
      Degeneration, Cystic                 |          1        1                                               1      |             
      Eosinophilic Focus                   |       2                       2                                   1      |             
      Fatty Change                         | 2  2  2     1  2  1  2  1  2     2  1  2  1  2  1  2  2     2  2  1     1|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         | 1  2     2  1     1  1  1     1     1                 1  2  1        1  1|             
      Mixed Cell Focus                     | 2  2                                2                                    |             
      Necrosis, Coagulative                | 1        1                                3                 1  2         |             
      Bile Duct, Hyperplasia               | 2        2  2     2  1  1  1  2     2  1           2  1  2  2     2  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       1              2   |             
      Ectopic Tissue                       |                                  X                                       |             
      Hyperplasia                          |    2     2           2              3                       3            |             
      Inflammation, Chronic                |    1                                                  1  1              1|             
      Pigmentation                         |                                                                          |             
      Acinus, Hyperplasia                  |                   1                                                      |             
      Duct, Hyperplasia                    |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                    2                     |             
      Hyperkeratosis                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                    2        1            |             
      Muscularis, Mineralization           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Mineralization                       |                                                                2         |             
      Ulcer                                |                                                                          |             
      Arteriole, Mineralization            |                                                                          |             
      Muscularis, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     2  1  1  1  2  2  2  3  1  1  2  1  1  2  2  2  2  2  2  1  2|             
      Atrioventricular Valve,              |                                                                          |             
          Mineralization, Focal            |                                           1                              |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     1  1     2           1     1        1        2  2  2  3  1  1  1|             
      Atrophy                              |                      3                                                   |             
      Hyperplasia                          |                                                                      1   |             
      Vacuolization Cytoplasmic            |       1        1  2     1        2  1  1  1     1  1     1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     1  1     2  3        1     1     3  1        2  2  2  3  1  1  1|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 1        1           1  1                                1           1  1|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                           2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  M  M  +  M  +  M  +  +  M  M  +  M  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                   2     2|             
      Pars Distalis, Cyst                  |                   2                                                      |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2     2     1           1  1        2              1  1     1  1  1      |             
      Pars Distalis, Necrosis, Coagulative |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                   2      |             
      Pars Intermedia, Cyst                |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        1     1  1     1        1        1     1        1  1     1     1|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Mineralization             |                                                                          |             
      Follicular Cell, Hyperplasia         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                      3        2     1                 2  2  2  3  2     2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 1           1     1  1                    1              1  2            |             
      Inflammation, Chronic Active         |    4                    3  1  2     2  1              1        2  3  3  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                                                        |             
      Inflammation, Acute                  |                                  1           1     1           2         |             
      Inflammation, Chronic Active         |                      3  3                       2     2                  |             
      Epithelium, Hyperplasia              |          1              2                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 2           2     2  2        2     2              1     2  2     2     3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                      2                                                   |             
      Arteriole, Necrosis, Fibrinoid       |                      2                                                   |             
      Interstitial Cell, Hyperplasia       | 1  1  1  1     1     1  1  2     1  1  2        1     1     1  1  1  1  1|             
      Seminiferous Tubule, Atrophy         | 3  4     3  4  3  4  4  3  1  4  1  3  1  3  2        3  4  4  3  4  4  4|             
      Seminiferous Tubule, Mineralization  |                            1              1                              |             
      Seminiferous Tubule, Necrosis,       |                                                                          |             
          Coagulative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |       2     1                                                            |             
      Mediastinal, Ectasia                 | 3                                                                        |             
      Mediastinal, Hemorrhage              |                   1                 1  2                                 |             
      Mediastinal, Hyperplasia             |                                                                         2|             
      Mediastinal, Pigmentation            |                                     1                                    |             
      Pancreatic, Angiectasis              |                                           2                              |             
      Pancreatic, Fibrosis                 |                                           2                              |             
      Pancreatic, Pigmentation             |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Congestion                           |                                                                          |             
      Ectasia                              | 2        2  1           3                 3                              |             
      Hemorrhage                           |                         3                                                |             
      Hyperplasia                          |          2           2                                                  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                                           2                              |             
      Hemorrhage                           |                3                                                         |             
      Infiltration Cellular, Histiocyte    |       1                 1           1              1  1  2  1  1  1  1   |             
      Pigmentation                         | 1  1     1  1     1  1  1                          1  1  1  1  1  1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               1     1                                    |             
      Depletion Lymphoid                   |             2              1                 3           2               |             
      Fibrosis                             |             2                                            4               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Coagulative, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                               2               |             
      Depletion Lymphoid                   | 2  3  3  2  2  2  2  2     2  2  3     2     2  3     3  2  3  2  3  3  2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  +  +  M  M  +  +  M  +  M|             
      Hyperplasia                          |          2                                                           2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Atrophy                              |                                                                   4      |             
      Cyst Epithelial Inclusion            |                                                                   X      |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Necrotizing                      |                                     4                                3   |             
      Subcutaneous Tissue, Fibrosis        |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                       2                  |             
      Meninges, Hemorrhage                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                 1                           |             
      Fibrosis                             | 1           1                                                            |             
      Foreign Body                         |                                           1                              |             
      Granuloma                            |                                                 1                        |             
      Hemorrhage                           |                                  1                                       |             
      Infiltration Cellular, Histiocyte    |       2     2     1  1     1  1  1     1  2                       1      |             
      Inflammation, Chronic                |                         1                          1        1  1     1   |             
      Inflammation, Chronic Active         |       1                                      2                           |             
      Alveolar Epithelium, Hyperplasia     |             1                                                           1|             
      Artery, Hyperplasia                  |                                           2                              |             
      Artery, Mineralization               | 1           1  1     1                 1           1                 1  1|             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              4                           |             
      Inflammation, Acute                  |                   1           1     1                             1  2  1|             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                           1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |       1                                                                  |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Chronic Active                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                 +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2            |             
      Cyst                                 |                      3                                                   |             
      Nephropathy                          | 2  2  1  2  2  2  3  4  2  2  3     3  2  4  1  1  3  2  3  2  3  4  2  4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|             
                                           | 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Collecting Tubule, Mineralization    |                                                                          |             
      Papilla, Necrosis                    |                      1                                                   |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Mineralization               |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                1  1        1              2                       2     2|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                3         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Submucosa, Hemorrhage                |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Parasite Metazoan                    | 1  1     1                                               1           1   |     13  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    1  1  1  1  1  1  1  1  1  1              1     1     1     1  1  1   |     37  1.1|
      Clear Cell Focus                     |          1        1              1  2     2     1  1              1  1   |     15  1.1|
      Degeneration, Cystic                 |                                                                      1   |      4  1.0|
      Eosinophilic Focus                   |    3     1           1                                            2      |      7  1.7|
      Fatty Change                         | 3  1  1  1  1  1  1  2  1        2  2  2     2     2     1  2  2  1  2  2|     41  1.6|
      Fibrosis                             |                   2                                                      |      1  2.0|
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         | 1     2           2  2  1  1     1  1           1  2     1     1  1  1   |     28  1.3|
      Mixed Cell Focus                     |                                                                          |      3  2.0|
      Necrosis, Coagulative                |                                                                         2|      6  1.7|
      Bile Duct, Hyperplasia               |    1  2  2  1  1  2  2  1  1  1  1  2     1  2           1     2  1  2   |     35  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +              +                       +   |   4        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      1  1  2        1                 4  1  2            |      9  1.7|
      Ectopic Tissue                       |                                                                          |      1     |
      Hyperplasia                          |          2     2  2                                                      |      8  2.3|
      Inflammation, Chronic                |    1     1                          1                             1      |      8  1.0|
      Pigmentation                         |                               2                                      1   |      2  1.5|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                            1                                2            |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |       1  1                                                               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                         2  2  2                                          |      4  2.0|
      Hyperkeratosis                       |                         2  2                                             |      3  2.0|
      Hyperplasia, Basal Cell              |                         2     2                                          |      4  1.8|
      Muscularis, Mineralization           |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                        2                                 |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                        1                                 |      1  1.0|
      Arteriole, Mineralization            |                                                 4                        |      1  4.0|
      Muscularis, Mineralization           |                                                 2     1                  |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  4  2  1  2  1  2  1  2  2  2  2  1  2  2  2     2  2  2  2  2  2  2|     48  1.8|
      Atrioventricular Valve,              |                                                                          |            |
          Mineralization, Focal            |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  2  2  1     2  2  1     2  1                 1  1  3  1           1   |     29  1.5|
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                   1     1     1           2  1  1                        |      7  1.1|
      Vacuolization Cytoplasmic            |    2  1                 1  2  1  1  1  1  1  1  1  1  1  1  1        1  2|     32  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  2  4  1     2  2  1  2  2  1           3  3  1  1  3  1           1   |     34  1.7|
      Fibrosis                             |       2                                                                  |      1  2.0|
      Hyperplasia                          |          1        1           2                                      1   |     11  1.1|
      Mineralization                       |       2                                                                  |      1  2.0|
      Necrosis                             |                                                                         3|      1  3.0|
      Thrombosis                           |                                                       4                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                                                        2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  M  M  M  M  +  M  +  +  M  +  M  +  M  +  +  M  M  M  +  M|  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |                                              1        4                  |      4  2.3|
      Pars Distalis, Cyst                  | 1                                                                        |      2  1.5|
      Pars Distalis, Hemorrhage            |                               3                                          |      1  3.0|
      Pars Distalis, Hyperplasia           | 1  2     2  1  1        2     2     2  2     2              2            |     22  1.5|
      Pars Distalis, Necrosis, Coagulative |                               3                                          |      1  3.0|
      Pars Intermedia, Angiectasis         |                                                       4                  |      2  3.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      C-Cell, Hyperplasia                  |          1     1  1     1        1     1  1           2        1     1   |     22  1.0|
      Follicle, Cyst                       |                                                    1                     |      1  1.0|
      Follicle, Mineralization             |                                                 1                        |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                            +        +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|
      Epithelium, Hyperplasia              | 2        1           2     1                    2              2        3|     16  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  43        |
      Fibrosis                             |                                        2                                 |      1  2.0|
      Inflammation, Acute                  |                                        2                                 |      1  2.0|
      Inflammation, Chronic                |                   2     1     1           2     2  1  1     2        2   |     16  1.4|
      Inflammation, Chronic Active         | 2  1  3        4     3     1     2  2                    2     2  4      |     22  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |             2                                                            |      5  1.4|
      Inflammation, Chronic Active         | 2  2  3  1     2  1              3     2  1     2  2     2     3  3  2   |     19  2.2|
      Epithelium, Hyperplasia              |          1                       1                                       |      4  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                   3  3        3           2     2                 2      |     17  2.2|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |    2                                                                     |      2  2.0|
      Arteriole, Necrosis, Fibrinoid       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1     2     1     1  1     1  1  1  1  2  1  1     1     1  1        1  1|     35  1.1|
      Seminiferous Tubule, Atrophy         | 3  4  3  4  1  4  4  4     4  4  2  3  1  4  4  4  3     3  4  4  3  3   |     44  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Mineralization  |             1                             1                 1            |      5  1.0|
      Seminiferous Tubule, Necrosis,       |                                                                          |            |
          Coagulative                      |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                                                                          |      2  1.5|
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |          2        2                             2     2  2               |      8  1.8|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                               2              4                           |      3  2.3|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Fibrosis                 |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
      Renal, Pigmentation                  |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  44        |
      Angiectasis                          |                                                                          |      1  1.0|
      Congestion                           |                2                                                         |      1  2.0|
      Ectasia                              | 2  4                    4                                2              2|     10  2.5|
      Hemorrhage                           |       2                    1     1  2                                    |      5  1.8|
      Hyperplasia                          | 1              1           2                    2                        |      7  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1  2  1  1     1  1  1  1  1  1  1  1     1     1  1     1  1  1  1  1   |     30  1.1|
      Pigmentation                         | 1  2  1  1     1  1  1  1  1  1  1  1     1     1  1     1  1  1  1  1   |     34  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  1.0|
      Depletion Lymphoid                   |                                                             3           4|      6  2.5|
      Fibrosis                             |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                              2                           |      1  2.0|
      Necrosis, Coagulative, Focal         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +|  42        |
      Cyst                                 |                                                                          |      2  2.0|
      Depletion Lymphoid                   |       3  2  2  3  2  2  2  3        3  3  2     3        3  3        2  3|     37  2.5|
      Hemorrhage                           |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  M  +  M  M  M  +  M  +  +  M  +  M  M  +  M  +  +  +  +  +  M|  21        |
      Hyperplasia                          |    1  1                    2              2        1     2  2     3      |     10  1.8|
      Pigmentation                         |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |          4                                                               |      1  4.0|
      Atrophy                              |                                                                          |      1  4.0|
      Cyst Epithelial Inclusion            |                            X                                             |      2     |
      Hyperkeratosis                       |          4                                                               |      1  4.0|
      Hyperplasia, Basal Cell              |          3                                                               |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Necrotizing                      |                                                                          |      2  3.5|
      Subcutaneous Tissue, Fibrosis        |                2                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Meninges, Hemorrhage                 |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  1.5|
      Fibrosis                             |                                                                          |      2  1.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Granuloma                            |                                                                          |      1  1.0|
      Hemorrhage                           |                                                             1            |      2  1.0|
      Infiltration Cellular, Histiocyte    |                                           1  1                 2         |     13  1.3|
      Inflammation, Chronic                |                1  1           1           1        1              1      |     11  1.0|
      Inflammation, Chronic Active         |       1              1  1                                2           2   |      7  1.4|
      Alveolar Epithelium, Hyperplasia     |                                  2           1           2     1     1   |      7  1.3|
      Artery, Hyperplasia                  |                   1                                                      |      2  1.5|
      Artery, Mineralization               | 1     1  1     1  1                 1        1  1        1  1  1     1  1|     21  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                             4            |      2  4.0|
      Inflammation, Acute                  | 1  1     1                       1        1                              |     11  1.1|
      Inflammation, Chronic                |             1                                                            |      2  1.0|
      Inflammation, Chronic Active         |                                     1              1              2  1   |      4  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peritracheal Tissue, Hemorrhage      |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        +                                 |   3        |
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                    +                                 |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                2           2                                             |      3  2.0|
      Cyst                                 |                1                                                         |      2  2.0|
      Nephropathy                          | 1  4  4  2  1  2  3  2  3  3  2  1  2  1  4  1  4  2  1  2  3  2  3  2  1|     49  2.3|
      Collecting Tubule, Mineralization    |                                  1     1        1        1           1   |      5  1.0|
      Papilla, Necrosis                    |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |             2                                                            |      1  2.0|
      Pelvis, Mineralization               |                                              1                           |      1  1.0|
      Pelvis, Epithelium, Hyperplasia      |                            2  1     1     2  2        2     2  2         |     14  1.6|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |          1           1  1     1           1                    1         |      6  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |             1                                                            |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                               3              3                           |      2  3.0|
      Renal Tubule, Hyperplasia            |                                           1     1                        |      3  1.7|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                          +               |   1        |
      Calculus Micro Observation Only      |                                                          X               |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8|            |
                                           | 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  45        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                           1                              |      2  1.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|             
                                           | 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +     +     +     +  +  M  +        M     +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   M     +     +     +     +  +  +  +        +     M      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +     +     +     +  +  +  +        +     +      |             
      Parasite Metazoan                    |                   1                       2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              A     +     +     +     +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              A     +     +     +     +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              M     +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              A     +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                                   1         |             
      Basophilic Focus                     | 1  2  1        1                 1        1     1  1  1  2        1  2   |             
      Clear Cell Focus                     |                      1                             3                    1|             
      Congestion                           |                      2                                                   |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                1           1                             1              2|             
      Fatty Change                         | 2  3  1  2  1  1  2  1  2  2  2  1     3     1  2  2  1  3  2     2  3  2|             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X              X                                    |             
      Infarct                              |          4                                                               |             
      Inflammation, Chronic Active         | 2  2              1  2     2           2              1  2        2     2|             
      Mixed Cell Focus                     |             1                          2                             1   |             
      Necrosis, Coagulative                |                            1  1                                      4   |             
      Bile Duct, Hyperplasia               | 1  1  1  1  1  2  1  2  2  1  2  2     2           1  2  2  1  1  2  1  2|             
      Kupffer Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                       +                       +   |             
      Inflammation, Chronic Active         |                      4                                               4   |             
      Necrosis, Coagulative                |                      3                                               4   |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +     +  +     +     +     +     +  +  +  +        +     +     +|             
      Atrophy                              |                                                 1                        |             
      Hyperplasia                          |          1                                   1                           |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +        +     +     +     +     +  +  +  +        +     +      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       1     2                                            2           2   |             
      Hyperkeratosis                       |       1     2                       2                                3   |             
      Hyperplasia, Basal Cell              |       1        1                    2                    2           2   |             
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |             
      Inflammation, Chronic Active         |       1                             3                                    |             
      Ulcer                                |             4                                                        3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|             
                                           | 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
      Mucosa, Necrosis                     |                                                                      2   |             
      Muscularis, Mineralization           |                1                       2              1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +     +     +     +  +  +  +        +     +      |             
      Cardiomyopathy                       |                   2     3     2     1     2  2  1  2        2     1      |             
      Atrium, Thrombosis                   |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                    2     2  1  1  1  3           2     1     2         |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |    1                       1     1                       1               |             
      Vacuolization Cytoplasmic            |       1     3     3     2           1  1  1  2           1  2     1  3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2              4     4     2  1  1     3           2           2        3|             
      Hyperplasia                          | 1  1     1  1              1           1        1              1        1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +  +  +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   M     M     M     +     M  M  M  M        M     M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +                 +     +     M     +     +  M  +  +        +     +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 3                                                                        |             
      Pars Distalis, Hyperplasia           |                   2     1                                                |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +     +     +     +  +  +  +        +     +      |             
      C-Cell, Hyperplasia                  |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Epithelium, Hyperplasia              | 1  3  2  2  2  2     2     1     1     2        2     1  3     3        2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +           +     +  +  +     +     +  +  +  +  +     M     +      |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                               1           2        1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|             
                                           | 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |       4                 1  4                          3           2      |             
                                            __________________________________________________________________________|             
   Prostate                                |                   +     +     +     +     +  +  +  +        +     +      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                   2                       2     2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +     +  +  +  +  +     +     +  +  +  +  +  +  +  +  +      |             
      Atrophy                              |    4     3  3        3     3                          4  3     3         |             
      Inflammation, Acute                  |                                     4                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                         1     2                    1              2  1   |             
      Seminiferous Tubule, Atrophy         | 4  4  4  4  4  4     4  1  4  1  4  4  4  4  4  3  4  4  4  1  4        4|             
      Seminiferous Tubule, Mineralization  | 1  1  1  1  1                 1        1  1  1           1  1  1     1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +     +     +     +  +  +  +        +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        M     M     +  +  M     +  +  +  +        +     +      |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Ectasia                 |                                              1                           |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |          1                                                               |             
      Renal, Hemorrhage                    |                                           2                              |             
      Renal, Pigmentation                  |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +        M     M     +     M     +  +  +  +        +     +      |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                 M     M     +  +  M     +  +  +  +        +     +      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1                                1                                       |             
      Pigmentation                         | 1                                1        1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +        +  +  +     +     M     +  +  +  +        +  +  +  +   |             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                               2              1  2           2            |             
      Fibrosis                             |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Pigmentation                         |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
          Active, Necrotizing              |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +     +     +     M     +  +  +  M        +     +      |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|             
                                           | 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                         2                 2  2  2           2     2      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  M     M     M     M     M  M  M  M  +     M     M      |             
      Galactocele                          |             2                                                            |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +     +     +     +     +  +  +  +  +     +     +     +|             
      Acanthosis                           |                                                       2                  |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Pseudoepitheliomatous   |                                                       2                  |             
      Inflammation, Acute, Hemorrhagic     |                                                                         2|             
      Inflammation, Acute, Necrotizing     |                                                       4                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +     +     +     +  +  +  +        +  +  +      |             
      Autolysis                            |                                                                3         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +              +            |             
      Hemorrhage                           |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +     +     +     +     +  +  +  +        +     +      |             
      Third Ventricle, Hemorrhage          |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                 +  +  +  +  +     +  +  +  +  +  +        +     +  +   |             
      Congestion                           |                      2     1  4        2        3                 2      |             
      Crystals                             |                                                                          |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                           1                              |             
      Granuloma                            |                                                    1                     |             
      Hemorrhage                           |                                                    1                     |             
      Infiltration Cellular, Histiocyte    | 1                       1                 1  1                           |             
      Inflammation, Chronic                |                      1                                                   |             
      Inflammation, Chronic Active         |                                           2                              |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Hyperplasia                  |                                                                          |             
      Artery, Mineralization               |                   1        1  1     1              1        1     1      |             
      Bronchus, Bronchiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +     +     +     +  +  +  +        +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|             
                                           | 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.05                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                 4           3            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                   1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                         2                                                |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                         2                    2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +     +     +     +  +  +  +        +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 2  4  4  3  4  4     4  2  3  2  4  4  3  2  2  2  3  4  3  3  4  2  4  3|             
      Collecting Tubule, Mineralization    |    1  1     1                                            1               |             
      Papilla, Necrosis                    |                                        1                 1     1        1|             
      Pelvis, Dilatation                   |                                     2                                    |             
      Pelvis, Epithelium, Hyperplasia      |          1  1  1                 1                             2         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |                      1     1     1                    1                 1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Mineralization                  |          1                                                               |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                              3                           |             
      Renal Tubule, Hyperplasia            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                     +                                    |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
      Calculus Micro Observation Only      |                                                             X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +     +     +     +     +  +  +  +     +  +     +      |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +     +              +  M     +     +     +  +     M     +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +     +           +     +     +     +     +  +     +     +  +      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +     M                 M     +     M     M  +     +     +  +      |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +     +           +     +     +     +     +  +     +     +  +      |  21        |
      Parasite Metazoan                    |       2                                                                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +     M                 +     +     +     M  +     +     +  +      |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +     +     +     +     +     +     +     +  +     +     +  +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +     +     +     +     +     +     +     +  +     +     +  +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +     +     +           +     +     +     +  +     +     +  +      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +     +     +           +     +     +     +  +     +     +  +      |  21        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     | 1  1  1  1  1  2  1  1     2  1           1  1        1     1           1|     27  1.2|
      Clear Cell Focus                     |    1  1        1                    2              3     1  1  2         |     11  1.5|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |          1                                                               |      1  1.0|
      Eosinophilic Focus                   |    1           2                             1     1  1                  |      9  1.2|
      Fatty Change                         | 2              2     3  2  2  2  3        2  2  2  2  1  2  2     2  1  2|     39  1.9|
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 1     1  1     2  1  2  2  2     2           2     1  2     1            |     23  1.7|
      Mixed Cell Focus                     |                                           1                              |      4  1.3|
      Necrosis, Coagulative                |                                     2  3                             2   |      6  2.2|
      Bile Duct, Hyperplasia               | 1  2  2  2  1  2  1  1  1  1  1  2     1  2  1     2  1  2  2  2     1  1|     43  1.5|
      Kupffer Cell, Hyperplasia            |                               1                                   2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +              +                                                |   5        |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
      Necrosis, Coagulative                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +     +     +     +     +     +  +  +  +     +  +      |  27        |
      Atrophy                              |                                                       3                  |      2  2.0|
      Hyperplasia                          |          2                                                               |      3  1.3|
      Inflammation, Chronic                |                                                                1         |      1  1.0|
      Inflammation, Chronic Active         |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +     +                 +     +     +     +  +     +     +  +  +   |  23        |
      Inflammation, Chronic                |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                      3  2  2                                            3|      8  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                      3  2  2                                            3|      8  2.3|
      Hyperplasia, Basal Cell              |                      2  2  2                                            3|      9  1.9|
      Hyperplasia, Pseudoepitheliomatous   |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |                            1                                             |      3  1.7|
      Ulcer                                |                      4  4                                               4|      5  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1                                                |      1  1.0|
      Mineralization                       |                   1                                                      |      1  1.0|
      Mucosa, Mineralization               |                                        2                                 |      1  2.0|
      Mucosa, Necrosis                     |                                                                          |      1  2.0|
      Muscularis, Mineralization           |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +     +                 +     +     +     +  +     +     +  +      |  20        |
      Cardiomyopathy                       |       2     1                             2     1  2     1     2  1      |     18  1.7|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 1     1     2  1  2  1                                1  2           2   |     19  1.6|
      Congestion                           |                                  3                                       |      1  3.0|
      Hyperplasia                          |                                                       1                 1|      6  1.0|
      Vacuolization Cytoplasmic            |          1  2     1  2  3     1           1  1  2  1     1  1     1     2|     26  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          | 1     1  2  2  1  2  1     4                 2        1  2  1        2   |     23  2.0|
      Hyperplasia                          | 1     2              1     2                                         2  1|     15  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +     +                 +     +     +     +  +  +  +     +  +      |  22        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M     M              +  +     +     +     +  M     M     +  +      |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +     +  +  +     +     +     +     +  +     +     +  +     +|  26        |
      Pars Distalis, Angiectasis           |             1                                                            |      1  1.0|
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |       1  1  1           1                 2                             2|      8  1.4|
      Pars Distalis, Pigmentation          | 1        1                                                               |      2  1.0|
      Pars Intermedia, Pigmentation        | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +     +              +  +     +     +     +  +     +     +  +      |  21        |
      C-Cell, Hyperplasia                  |       2                    2                                             |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
      Epithelium, Hyperplasia              | 1  3           2  2  2     2     2           1              1        3  1|     26  1.9|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  +           +  +  +     +     +     M  +     +  +  +  +      |  25        |
      Abscess                              |          3                                                               |      1  3.0|
      Inflammation, Chronic                |             2                       2                          1  2      |      7  1.6|
      Inflammation, Chronic Active         |       3                 4  4              2        2     2  3            |     12  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +     +           +     +     +     +     +  +     +     +  +      |  21        |
      Inflammation, Acute                  |                               2           2              2               |      3  2.0|
      Inflammation, Chronic Active         |                         2                                      2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +  +     +  A  +     +  +     +     +  +  M  +|  36        |
      Atrophy                              |    2     2     2     4     3                                            2|     14  2.9|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       | 1     1                       1              1  1           1  2  1     1|     14  1.2|
      Seminiferous Tubule, Atrophy         | 4  4  2  4  4  4  4  4  4  4     4  4  4  2  2        3  4           4  1|     41  3.5|
      Seminiferous Tubule, Mineralization  | 1  1  1  1     1  1  1           1  1        1        1  1               |     26  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +     +                 +     +     +     +  +     +     +  +      |  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +        +  +     +     +  +  +     +  +     +  +  +  +  +   |  26        |
      Mediastinal, Depletion Lymphoid      |                                        4                                 |      1  4.0|
      Mediastinal, Ectasia                 |                                                                          |      1  1.0|
      Mediastinal, Hemorrhage              |          1                                                               |      1  1.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                      4                                                   |      1  4.0|
      Mediastinal, Pigmentation            |          1                             1                                 |      2  1.0|
      Pancreatic, Hemorrhage               |          3                                                               |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +     +                 +     +     +     +  +     M     M  +  +   |  18        |
      Ectasia                              |                                     3                                    |      1  3.0|
      Hemorrhage                           |                                                 2                    3   |      3  2.3|
      Hyperplasia                          |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       M     +                 +     +     +     +  +     +  +  +  +      |  19        |
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             1            |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |                                                             1            |      4  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +     +     +     +     +  +  +  +  +  +     +  +  +  +  +  +|  32        |
      Congestion                           |                               3                                          |      1  3.0|
      Depletion Lymphoid                   |          2        2     3              3        2        1     3     2  3|     13  2.2|
      Fibrosis                             |          2                                                               |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Pigmentation                         |                                                                3         |      1  3.0|
      Capsule, Inflammation, Chronic       |                                                                          |            |
          Active, Necrotizing              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +     +           +     +     +     +     +  +     +     M  +      |  18        |
      Congestion                           |                               2                                          |      1  2.0|
      Depletion Lymphoid                   |       1     3           4     3     2     3        1                     |     13  2.2|
      Hemorrhage                           |                               2                 1                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +     M        +  +     M     M     +  +  M  M     M     M  M      |   8        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |                         1                 2                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +     +     +     +     +  +  +     +  +     +     +  +  +   |  27        |
      Acanthosis                           | 3                                                                        |      2  2.5|
      Hyperkeratosis                       | 3                                                                        |      1  3.0|
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |      1  2.0|
      Inflammation, Acute, Hemorrhagic     |                                                                          |      1  2.0|
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Subcutaneous Tissue, Fibrosis        | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +     +                 +     +     +     +  +     +     +  +      |  21        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   3        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +     +                 +     +     +     +  +     +     +  +      |  20        |
      Third Ventricle, Hemorrhage          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +     +  +  +  +  +  +  +     +  +     +     +  +     +|  34        |
      Congestion                           | 2                             3                          2     4         |     10  2.5|
      Crystals                             |                                     4                                    |      1  4.0|
      Edema                                |                                                          2     1         |      2  1.5|
      Fibrosis                             |                                                                          |      1  1.0|
      Granuloma                            |                                                                          |      1  1.0|
      Hemorrhage                           |                                     4                                    |      2  2.5|
      Infiltration Cellular, Histiocyte    | 1     1     1                       4     1     1  1           1  1      |     13  1.2|
      Inflammation, Chronic                |             2     1                             1                        |      4  1.3|
      Inflammation, Chronic Active         |                                     4     1                              |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |             1                             1                    1         |      3  1.0|
      Artery, Hyperplasia                  |       2                                                                  |      1  2.0|
      Artery, Mineralization               | 1  1        1     1                    1  1                    1  1     1|     16  1.0|
      Bronchus, Bronchiectasis             |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +     +                 +     +     +     M  +     +     +  +      |  19        |
      Edema                                |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                3         |      1  3.0|
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |             1                 2                                          |      3  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +     +              +  +     +     +     +  +     +     +  +      |  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   1        |
      Inflammation, Chronic Active         |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Osseous                  |    4                                                                     |      1  4.0|
      Nephropathy                          | 4  3  2  4  2  3  3  4  4  4  1  3  3  3  2  4  1  2  4  3  2  1  2  3  4|     49  3.0|
      Collecting Tubule, Mineralization    |                   1  1  1                             1     1        1   |     10  1.0|
      Papilla, Necrosis                    |                   1     1        1  1     1                    2         |     10  1.1|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1|            |
                                           | 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.05                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    G/KG                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Epithelium, Hyperplasia      |    1                                                                    2|      7  1.3|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             | 1        1     1  1        1                       2     1              1|     13  1.1|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Mineralization                  |                                                                          |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +                 +     +     +     +  +     +     +  +      |  22        |
      Calculus Micro Observation Only      | X                                                                        |      1     |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|             
                                           | 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                       4                  |             
      Parasite Metazoan                    |             1                                      2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             1     1           1        2           X        2  1  1     1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Basophilic Focus                     |    1  1  2  X  1     1           1           1        1        1  1     1|             
      Clear Cell Focus                     |             1        1        1  1              2        1  1     1      |             
      Degeneration, Cystic                 |                                                          1              2|             
      Eosinophilic Focus                   |                                  1     1        2  2                     |             
      Fatty Change                         | 1  2  1  2  1  1  3  2  1  2  1  2  2  2  2  2  1  1  1  1  2  2  1  2  1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |    3                    2                                                |             
      Inflammation, Chronic Active         |                1     1     1     1     2  2                 1        1  1|             
      Mixed Cell Focus                     | 1              1                                                        1|             
      Necrosis, Coagulative                |                               1     1        1                           |             
      Bile Duct, Hyperplasia               |    1  1  1     1  1  1  2  2  1  1        1     1  2     2  2  1        1|             
      Centrilobular, Cytomegaly            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2     1           2                       1        1  1      |             
      Hyperplasia                          |       2                                                                 2|             
      Inflammation, Chronic                |                            1  1                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
      Parotid Gland, Atrophy               |                                                                      1   |             
      Submandibular Gland, Atrophy         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|             
                                           | 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |       2  2              2                                                |             
      Hyperkeratosis                       |       1  2              2                                                |             
      Hyperplasia, Basal Cell              |          2                                                               |             
      Inflammation, Chronic Active         |    1                    2                                                |             
      Ulcer                                |       4  2                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       2                  |             
      Inflammation, Chronic Active         |    2  2                 2              1                                 |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  4  2  2  2  1  3  2  2  2  2  2  2  2     2  2  1  3  2  2|             
      Atrium, Congestion                   |                                                                          |             
      Atrium, Thrombosis                   |                               3                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1        1  1                 1  1  1     3  1                    2   |             
      Hyperplasia                          |             1        1           1           2                           |             
      Vacuolization Cytoplasmic            |    1  3  2     1     1  2     1  1  1        2        3  1  1  1  1     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  1     1  1        4  2              3  3  1                 3  2   |             
      Hyperplasia                          |    2        1        2           1                 1     1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  M  +  M  M  +  +  M  M  M  +  +  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                3                                                         |             
      Pars Distalis, Cyst                  |                                                                         2|             
      Pars Distalis, Hyperplasia           |    1  2  1  1     2  2  1  2     1  1  2           2        1     3  1  1|             
      Pars Intermedia, Angiectasis         |                3                                                         |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1  2  1        1     1        1              1           1  1  1  1|             
      Follicle, Cyst                       |       1                                                                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|             
                                           | 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |    2        2           2  1  2     2  2     2  2        2        2  2  1|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
      Inflammation, Acute                  |                                                          3               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    2  2  2  2  2  2  2  2  3  1  2  2  1  1  2  3  2  4     1  2  1  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |             1  3  2  1                                1                  |             
      Inflammation, Chronic                |    1                                                     1     1         |             
      Inflammation, Chronic Active         |                         2           2     3     2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |          3  3           2        3  3     3     3  3     2           3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1        1  1     1  1  1        1  1  1     1  1     1     1            |             
      Seminiferous Tubule, Atrophy         | 2  4  3  4  4  4  2  4  3  4  3  4  4  4     4  4  4  2  1  4     4  4   |             
      Seminiferous Tubule, Mineralization  |          1  1           1        1     1        1     1     1  1         |             
      Seminiferous Tubule, Necrosis,       |                                                                          |             
          Coagulative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Hemorrhage              | 3                                   1                                    |             
      Mediastinal, Pigmentation            |                                           1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                3                          3                              |             
      Hematocyst                           |                                                                          |             
      Hemorrhage                           |    2           2                                         2               |             
      Hyperplasia                          |                                                                   2      |             
      Infiltration Cellular, Histiocyte    |                         1           1                                   1|             
      Pigmentation                         |                         1                                               1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Hemorrhage                           |                         1                          3                     |             
      Infiltration Cellular, Histiocyte    |    1  1  1  1        1  1  1  1  1  1  1  1  1  1        1  1     1  1  1|             
      Pigmentation                         |    1  1  1  3           1  1  1  1     1     1  1        1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|             
                                           | 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   | 2                 2                 4              3  3                  |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hyperplasia, Reticulum Cell          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   | 1  2        3  2  3  1  3        3  3  2     2        2  3  3     3  2   |             
      Hemorrhage                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  M  +|             
      Hyperplasia                          |       2  1  2  2        2     2     1  2        2        1  1     1     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                                                     2      |             
      Cyst Epithelial Inclusion            |                                                                   X      |             
      Hyperkeratosis                       |             3                                                     2      |             
      Hyperplasia, Basal Cell              |             3                                                     2      |             
      Inflammation, Chronic Active         |             2                                                            |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Hemorrhage                 |                                                                          |             
      Thalamus, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                 2                                                      |             
      Crystals                             |                                                                          |             
      Edema                                |                                                                          |             
      Granuloma                            |                                                                2         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                             1              1  1                  |             
      Inflammation, Chronic                |                      1                 1                                 |             
      Inflammation, Chronic Active         |                         1                                               1|             
      Metaplasia, Focal, Osseous           |          1                                                               |             
      Pigmentation                         |    1                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Artery, Hyperplasia                  |                            1                                             |             
      Artery, Mineralization               |    1  1     1        1        1  1  1  1     1  1        1  1  1  1     1|             
      Bronchiole, Epithelium, Hyperplasia  |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|             
                                           | 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.1 G/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Inflammation, Acute                  |                            1                 1           1               |             
      Inflammation, Chronic                |                                                                1         |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 2                                                                        |             
      Nasolacrimal Duct, Metaplasia,       |                                                                          |             
          Squamous                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +     I                          +   |             
      Cataract                             |                                                                      3   |             
      Retina, Degeneration                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       1                                                              2   |             
      Cyst                                 |                                                          1               |             
      Nephropathy                          | 1  4  4  4  4  3  1  3  4  4  3  3  3  4  4  3  4  3  1  2  4  1  4  1  4|             
      Collecting Tubule, Mineralization    | 1  1  1     1        1  1  1  1        1  1  1  1  1  1     1  1     1  1|             
      Papilla, Necrosis, Coagulative       |                                                                          |             
      Papilla, Necrosis                    |    2     2  2  1  2  2     1              2  2  2  2  2  2  1     2      |             
      Pelvis, Dilatation                   |                1                                                         |             
      Pelvis, Epithelium, Hyperplasia      |    2                    1              2                    1     2     1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Inflammation, Acute             |             1  2     1  1  1     1  1  1  1  1  1        1        1      |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                     2                                    |             
      Renal Tubule, Hyperplasia            |             1                             1                              |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +                              |             
      Calculus Micro Observation Only      |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  M  +  M  M  +  +  M  M  +  +  +  +  +  +  +  M  M  M  M  M  +  M  +|  32        |
      Inflammation, Acute, Necrotizing     | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                         1                    1        1                  |     12  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                       1                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |             3                                                            |      1  3.0|
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
      Epithelium, Hyperplasia              |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     2                                    |      2  1.5|
      Basophilic Focus                     |       1  1              1     1     1  1  1     1     1  1  1  1     3   |     25  1.1|
      Clear Cell Focus                     |    1  1  1              2     1     1     1  1  1        1  1            |     19  1.1|
      Degeneration, Cystic                 |                               1                             1            |      4  1.3|
      Eosinophilic Focus                   |                2              1              1           1  1     1      |     10  1.3|
      Fatty Change                         | 1  1  2  1  1  2  1  1  1  1  1     1  2  1  2  1  2  2  1  2  2  1  1  1|     49  1.4|
      Hepatodiaphragmatic Nodule           |          X                                                               |      1     |
      Hyperplasia                          |                                                                   3      |      3  2.7|
      Inflammation, Chronic Active         |    1     1                             1     2        2  1  1  1         |     17  1.2|
      Mixed Cell Focus                     |          1        3                 1     2                              |      7  1.4|
      Necrosis, Coagulative                |                1                                   3                     |      5  1.4|
      Bile Duct, Hyperplasia               |    1           1  1  1     1  1  1     2  1     1  1  1        1     1  2|     32  1.2|
      Centrilobular, Cytomegaly            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                       +                                       |   3        |
      Necrosis, Coagulative                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   1           1     3  2  1  1  1        1     1         |     15  1.3|
      Hyperplasia                          |    3  2        1                                   1                     |      6  1.8|
      Inflammation, Chronic                |                                              1  1  1                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Atrophy                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
      Parotid Gland, Atrophy               |                                                                          |      1  1.0|
      Submandibular Gland, Atrophy         |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    3  2                    2                                      2      |      7  2.1|
      Hyperkeratosis                       |    2  2                    2                                      2      |      7  1.9|
      Hyperplasia, Basal Cell              |                                                                   2      |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Ulcer                                |    4  2                    4                                      4      |      6  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |             2                                                            |      2  2.0|
      Inflammation, Chronic Active         |       1                                   1                              |      6  1.5|
      Mineralization                       |                            2                                             |      1  2.0|
      Ulcer                                |                            4                                             |      1  4.0|
      Epithelium, Hyperplasia              |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  1  2  1     2  2  2  1  1  2  2  1  1  4  2  2  2|     48  2.0|
      Atrium, Congestion                   |                3                                                         |      1  3.0|
      Atrium, Thrombosis                   |                X                                                         |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          2        1                 2        2        1  2  2  1     1   |     18  1.4|
      Hyperplasia                          |          3  1     1                    1                 1               |      9  1.3|
      Vacuolization Cytoplasmic            | 1  2  1  2  3  1        1  2     1  1           1  2     1  1     2  1   |     32  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  49        |
      Angiectasis                          |    3           2  1        1        2        2     1  1  2  2     2  2   |     23  1.9|
      Hyperplasia                          |    1              1           1     2                             3  1   |     12  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                                                     1               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  M  M  M  +  +  M  M  M  +  +  M  M  M  M  M  +  M  M  M  +  +|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                 1                        |      2  1.5|
      Pars Distalis, Hyperplasia           |    1     1           1  1  2     1              1     2     1  1         |     26  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                              1                           |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1                    1     1     1  1                           |     17  1.1|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |          1                                                     1         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |    3  2  2                 1              2  2  1     2  2  1  2  1  2   |     26  1.8|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                             2            |      2  2.5|
      Inflammation, Chronic                |    2     1           1  1     1     1     1                              |      7  1.1|
      Inflammation, Chronic Active         |       1        2  1        2           2     1  2  2  2  2     2  2  2   |     36  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 | 3                                                                        |      1  3.0|
      Inflammation, Acute                  |                2                       1                          2     2|      9  1.7|
      Inflammation, Chronic                |                                                                1         |      4  1.0|
      Inflammation, Chronic Active         |       2                 2  2        1        2              2            |     10  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |    3  3        1  3        3  3     3     3              3  1  3  3  3   |     23  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       3                  |      1  3.0|
      Interstitial Cell, Hyperplasia       | 1  1     1  1     1  1  2  1     1     1     1  1     1  1  1        1   |     29  1.0|
      Seminiferous Tubule, Atrophy         |    4  4  4  1  3  4  2  1  4  4  4  4  2     4  4  4  4  4  4  4  3  4  2|     45  3.4|
      Seminiferous Tubule, Mineralization  |                1  1        1                    1                    1   |     14  1.0|
      Seminiferous Tubule, Necrosis,       |                                                                          |            |
          Coagulative                      |                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Depletion Lymphoid      |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hemorrhage              |             2     2        2        2                             2      |      7  2.0|
      Mediastinal, Pigmentation            |                                  4  1                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  M|  41        |
      Congestion                           |                   4                                                      |      1  4.0|
      Ectasia                              |                                                                          |      2  3.0|
      Hematocyst                           |                   X                                                      |      1     |
      Hemorrhage                           |                   1                                                  2   |      5  1.8|
      Hyperplasia                          |                                                             2            |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.0|
      Pigmentation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hemorrhage                           |                   3                                2              1      |      5  2.0|
      Infiltration Cellular, Histiocyte    |       1  1     1           1  1     1     1  1  1  1  1  1  1  1  1  1   |     35  1.0|
      Pigmentation                         |       1  1     1           1  1     1     1  1  1  1  1  1  1  1  1  1   |     32  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               3                                          |      1  3.0|
      Depletion Lymphoid                   | 1                          1                                      1     3|      9  2.2|
      Hematopoietic Cell Proliferation     |                2     2                                                   |      3  2.0|
      Hyperplasia, Reticulum Cell          |                   2        2        3                                    |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Cyst                                 |                                        2                                 |      1  2.0|
      Depletion Lymphoid                   |    2  2  2  2  2  3  2  2  3  2  4     2     2  3  4  2  2  2  3  3  3  2|     38  2.4|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +  M  +  M  M  M  M  +  M  M  M  M  M  M  +  M  M  +  +  M  M  M|  24        |
      Hyperplasia                          |    2     2     2                                   2        3  1         |     19  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      2  2.5|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Hyperplasia, Basal Cell              |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Hemorrhage                 | 1                                                                        |      1  1.0|
      Thalamus, Mineralization             |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                         2                                               3|      4  2.3|
      Crystals                             |    1                                                                     |      1  1.0|
      Edema                                | 1                                                                        |      1  1.0|
      Granuloma                            |                         1                                                |      2  1.5|
      Hemorrhage                           | 1                                                                        |      1  1.0|
      Infiltration Cellular, Histiocyte    |                1  1  1                 1           1        1     1  1   |     12  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |    1     1                                   1        2                  |      6  1.2|
      Metaplasia, Focal, Osseous           |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    1     1        1                                            1         |      5  1.0|
      Artery, Hyperplasia                  |                                                                          |      1  1.0|
      Artery, Mineralization               | 1  1     1  1  1           1                             1        1  1   |     24  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                      2                                                   |      2  2.0|
      Inflammation, Acute                  | 4                                         1                              |      5  1.6|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                  3                                       |      2  3.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           | 4                                                                        |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                  2                                       |      2  2.0|
      Nasolacrimal Duct, Metaplasia,       |                                                                          |            |
          Squamous                         | 4           2                                                           1|      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    I     I                                                        +  I   |   3        |
      Cataract                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05063-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           PHENYLBUTAZONE                                      Date: 05/01/97  
Route: GAVAGE                                                                                                     Time: 07:53:22  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5|            |
                             DAY ON TEST   | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7|            |
                                           | 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.1 G/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   2                             1  2  1     2        2   |      8  1.6|
      Cyst                                 |       1                                                                  |      2  1.0|
      Nephropathy                          | 2  4  4  4  4  3  2  2  1  4  3  2  4  2  3  2  3  4  3  3  3  3  4  4  2|     50  3.0|
      Collecting Tubule, Mineralization    | 1     1  1  1  1           1     1  1  1  1  1     1  1  1  1  1        1|     35  1.0|
      Papilla, Necrosis, Coagulative       | 2                                                                        |      1  2.0|
      Papilla, Necrosis                    |    2  2     1  1                    1  1              2              2  2|     24  1.7|
      Pelvis, Dilatation                   |                                                                          |      1  1.0|
      Pelvis, Epithelium, Hyperplasia      |       1                       1     2     2     1        1               |     12  1.4|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Inflammation, Acute             |    1  1  1  1  1  1        1  1     1     1        1     1     1  1      |     27  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                  4                                       |      1  4.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                     2                                    |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.