National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2308

TDMS Study 05067-10 Pathology Tables

NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96
Route: GAVAGE                                                                                                     Time: 12:52:56

                                                           CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:   58-55-9

       Lock Date:  07/14/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            4           11            9                                     
    Natural Death                                      6            9            5            8                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           34           33                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (48)         (47)         (49)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (49)         (47)         (48)                                   
   Intestine Large, Cecum                             (48)         (45)         (47)         (47)                                   
      Leiomyosarcoma                                                1 (2%)                    1 (2%)                                
   Intestine Small, Jejunum                           (47)         (46)         (47)         (43)                                   
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                         8 (16%)      5 (10%)      6 (12%)      4 (8%)                                
      Hepatocellular Carcinoma, Multiple               3 (6%)                                 1 (2%)                                
      Hepatocellular Adenoma                          17 (34%)      9 (18%)      9 (18%)      3 (6%)                                
      Hepatocellular Adenoma, Multiple                 3 (6%)       2 (4%)       3 (6%)                                             
      Hepatocholangiocarcinoma                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       6 (12%)      2 (4%)       2 (4%)                                
      Ito Cell Tumor Malignant, Multiple                            1 (2%)                                                          
   Mesentery                                          (10)         (8)          (6)          (5)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (10%)      1 (13%)                   1 (20%)                               
      Histiocytic Sarcoma                                           1 (13%)                   1 (20%)                               
      Sarcoma                                          1 (10%)                                                                      
      Sarcoma, Metastatic, Skeletal Muscle                          1 (13%)                                                         
   Pancreas                                           (50)         (49)         (49)         (49)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Squamous Cell Papilloma                          4 (8%)       2 (4%)       2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (49)         (49)         (48)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Adenoma                                                                                 1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Capsule, Adenoma                                 1 (2%)                                                                       
      Capsule, Hepatocholangiocarcinoma,                                                                                            
          Metastatic, Liver                                         1 (2%)                    1 (2%)                                
      Capsule, Histiocytic Sarcoma                                  2 (4%)                    1 (2%)                                
   Adrenal Medulla                                    (50)         (48)         (50)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
   Pituitary Gland                                    (49)         (45)         (50)         (48)                                   
      Pars Distalis, Adenoma                           9 (18%)      7 (16%)      7 (14%)      5 (10%)                               
      Pars Distalis, Histiocytic Sarcoma                            1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cystadenoma                                                                1 (2%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                           4 (8%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           4 (8%)       3 (6%)       1 (2%)                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Endometrium, Polyp Stromal                       1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Sarcoma Stromal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                           2 (4%)                    1 (2%)                                
   Lymph Node                                         (6)          (8)          (7)          (6)                                    
      Histiocytic Sarcoma                                           1 (13%)                                                         
      Iliac, Histiocytic Sarcoma                                    2 (25%)                                                         
      Inguinal, Histiocytic Sarcoma                                 1 (13%)                                                         
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Liver                                        1 (13%)                                                         
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (17%)      1 (13%)                                                         
      Mediastinal, Histiocytic Sarcoma                              2 (25%)                                                         
      Renal, Histiocytic Sarcoma                                    2 (25%)                                                         
   Lymph Node, Mandibular                             (48)         (49)         (44)         (43)                                   
      Histiocytic Sarcoma                                           3 (6%)                                                          
   Lymph Node, Mesenteric                             (48)         (46)         (48)         (45)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                           3 (7%)                    1 (2%)                                
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)         (48)                                   
      Hemangiosarcoma                                               2 (4%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)                    1 (2%)                                
   Thymus                                             (47)         (44)         (49)         (47)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                                           2 (5%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Pinna, Histiocytic                                                                                       
          Sarcoma                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Fibrosarcoma                                                      1 (2%)                                             
   Skeletal Muscle                                    (3)          (3)          (2)          (1)                                    
      Fibrosarcoma                                                  1 (33%)                                                         
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (33%)      1 (33%)                   1 (100%)                              
      Sarcoma                                          1 (33%)      1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Histiocytic Sarcoma                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       4 (8%)       4 (8%)       3 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                           4 (8%)       1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (6)          (8)          (2)                                    
      Adenoma                                          6 (100%)     5 (83%)      4 (50%)      2 (100%)                              
      Carcinoma                                                                  2 (25%)                                            
      Histiocytic Sarcoma                                           1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           3 (6%)                                                          
   Urinary Bladder                                    (49)         (49)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       8 (16%)      4 (8%)       2 (4%)                                
      Lymphoma Malignant                              11 (22%)      8 (16%)     10 (20%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          39          41          28                                       
     Total Primary Neoplasms                           79          63          62          37                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          27          27          18                                       
     Total Benign Neoplasms                            49          33          36          20                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          24          22          17                                       
     Total Malignant Neoplasms                         30          30          26          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           4           1           1                                       
     Total Metastatic Neoplasm                         15          20           2           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      15 MG/KG     50 MG/KG     150                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            6            4           15                                     
    Moribund Sacrifice                                 9            9            2            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           35           44           26                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (46)         (47)         (42)                                   
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (49)         (49)         (41)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)         (47)         (47)         (41)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                                     2 (4%)                                                          
      Hepatocellular Carcinoma                        12 (24%)     13 (26%)     10 (20%)      2 (4%)                                
      Hepatocellular Carcinoma, Multiple               7 (14%)      1 (2%)       2 (4%)                                             
      Hepatocellular Adenoma                          14 (28%)     12 (24%)     10 (20%)      2 (4%)                                
      Hepatocellular Adenoma, Multiple                 7 (14%)      6 (12%)      2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
   Mesentery                                          (10)         (4)          (2)                                                 
      Histiocytic Sarcoma                              1 (10%)      1 (25%)                                                         
      Sarcoma                                                       1 (25%)                                                         
   Pancreas                                           (50)         (49)         (49)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       4 (8%)                    1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (43)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      15 MG/KG     50 MG/KG     150                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Capsule, Adenoma                                 4 (8%)       2 (4%)       1 (2%)       1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (48)         (44)                                   
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                               1 (2%)                                                          
      Follicular Cell, Adenoma                                      1 (2%)                    2 (4%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
   Preputial Gland                                    (49)         (48)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Prostate                                           (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node                                         (5)          (6)          (5)          (3)                                    
      Mediastinal, Carcinoma, Metastatic, Lung         1 (20%)                                                                      
      Pancreatic, Histiocytic Sarcoma                  1 (20%)                                                                      
      Renal, Histiocytic Sarcoma                                                 1 (20%)                                            
   Lymph Node, Mandibular                             (42)         (47)         (47)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (46)         (50)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (49)         (50)         (49)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Thymus                                             (43)         (42)         (44)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      15 MG/KG     50 MG/KG     150                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)      6 (12%)      8 (16%)      3 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      1 (2%)       5 (10%)      1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (4)          (2)          (2)                                    
      Adenoma                                          1 (100%)     3 (75%)      2 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                             Page  10                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      15 MG/KG     50 MG/KG     150                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant                               5 (10%)      3 (6%)       5 (10%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05067-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/03/96  
Route: GAVAGE                                                                                                     Time: 12:52:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      15 MG/KG     50 MG/KG     150                                       
                                                   CONTROL                                MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          42          38          13                                       
     Total Primary Neoplasms                           76          69          54          16                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          29          22           9                                       
     Total Benign Neoplasms                            36          40          27          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          24          25           4                                       
     Total Malignant Neoplasms                         40          29          27           4                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           1                                                               
     Total Metastatic Neoplasm                          9           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.