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TDMS Study 05067-09 Pathology Tables

NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96
Route: GAVAGE                                                                                                     Time: 17:04:03

                                                           CORE STUDY




       Facility:  Southern Research Institute

       Chemical CAS #:  58-55-9

       Lock Date:  09/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           12           14            7                                     
    Natural Death                                      1            7            3            7                                     
    Dosing Accident                                                 1                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           30           33           33                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (50)         (50)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Mesentery                                          (11)         (12)         (8)          (4)                                    
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (8%)                                                          
      Fibroma                                                                                 1 (25%)                               
      Sarcoma                                                                    1 (13%)                                            
   Oral Mucosa                                                                  (1)          (2)                                    
      Hemangiosarcoma                                                            1 (100%)                                           
      Squamous Cell Papilloma                                                                 1 (50%)                               
   Pancreas                                           (50)         (48)         (49)         (50)                                   
      Acinus, Adenoma                                  1 (2%)       1 (2%)                    2 (4%)                                
      Acinus, Sarcoma, Metastatic, Mesentery                                     1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (1)                       (1)                                                 
      Squamous Cell Carcinoma                          1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (47)         (50)         (49)         (49)                                   
      Pars Distalis, Adenoma                          22 (47%)     17 (34%)     17 (35%)     14 (29%)                               
      Pars Distalis, Adenoma, Multiple                              1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  3 (6%)       7 (14%)      5 (10%)      6 (12%)                               
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Carcinoma                                                     2 (4%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Arrhenoblastoma Benign                           1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Endometrium, Carcinoma                                                                  1 (2%)                                
      Endometrium, Leiomyoma                                                                  1 (2%)                                
      Endometrium, Polyp Stromal                       9 (18%)      7 (14%)     11 (22%)      7 (14%)                               
      Endometrium, Polyp Stromal, Multiple                                       1 (2%)                                             
      Endometrium, Sarcoma Stromal                     1 (2%)       1 (2%)       3 (6%)                                             
   Vagina                                             (1)                                                                           
      Schwannoma Malignant                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
   Lymph Node                                         (9)          (10)         (9)          (8)                                    
      Mediastinal, Sarcoma, Metastatic, Mesentery                                1 (11%)                                            
   Lymph Node, Mandibular                             (49)         (48)         (50)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (48)         (50)         (50)                                   
   Thymus                                             (49)         (49)         (48)         (50)                                   
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)                                   
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Fibroadenoma                                    17 (34%)     17 (34%)     11 (22%)     12 (24%)                               
      Fibroadenoma, Multiple                           5 (10%)      2 (4%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                                            1 (2%)                                             
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
      Subcutaneous Tissue, Melanoma Benign             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)          (1)                                    
      Sarcoma, Metastatic, Mesentery                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Glioma Malignant                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (50)         (49)                                   
      Lipoma                                                                     1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            10 (20%)      8 (16%)      9 (18%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          41          40          36                                       
     Total Primary Neoplasms                           87          72          69          65                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          39          32          30                                       
     Total Benign Neoplasms                            69          59          51          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          11          16          14                                       
     Total Malignant Neoplasms                         18          13          18          14                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      2           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           11           18           13                                     
    Natural Death                                      5            5            2           13                                     
    Dosing Accident                                    1            1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           33           29           24                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (49)         (48)         (50)         (49)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Ileum                             (49)         (48)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       2 (4%)                    1 (2%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (16)         (16)         (17)         (27)                                   
      Histiocytic Sarcoma                              1 (6%)                                                                       
   Oral Mucosa                                        (1)                       (1)                                                 
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Acinus, Adenoma                                  8 (16%)      6 (12%)      4 (8%)       4 (8%)                                
      Acinus, Adenoma, Multiple                        2 (4%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
   Tongue                                             (1)                       (1)          (1)                                    
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Pheochromocytoma Malignant                                    2 (4%)                                                          
      Pheochromocytoma Malignant, Multiple             1 (2%)                                                                       
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          5 (10%)      5 (10%)      6 (12%)      9 (18%)                               
      Bilateral, Pheochromocytoma Benign               2 (4%)                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                        2 (4%)       1 (2%)                                                          
      Carcinoma, Multiple                              1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)         (50)         (48)                                   
      Pars Distalis, Adenoma                          19 (38%)     18 (37%)     16 (32%)     10 (21%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  5 (10%)      1 (2%)       3 (6%)       1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (4%)                                                          
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                                                 2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (2)          (3)          (3)                                    
      Fibrosarcoma, Metastatic, Spleen                 1 (50%)                                                                      
   Tissue NOS                                                      (2)          (1)                                                 
      Mediastinum, Hemangioma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (49)         (50)         (50)                                   
      Adenoma                                                       2 (4%)       4 (8%)       3 (6%)                                
      Carcinoma                                        3 (6%)       2 (4%)                    3 (6%)                                
      Bilateral, Carcinoma                                                                    1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           42 (84%)     38 (76%)     41 (82%)     43 (86%)                               
      Interstitial Cell, Adenoma                       4 (8%)       4 (8%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (13)         (11)         (12)         (9)                                    
      Inguinal, Fibrous Histiocytoma                                1 (9%)                                                          
      Mediastinal, Fibrous Histiocytoma                             1 (9%)                                                          
      Mediastinal, Histiocytic Sarcoma                 1 (8%)                                                                       
   Lymph Node, Mandibular                             (48)         (49)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (49)         (50)         (50)         (49)                                   
      Fibroma                                                       2 (4%)       1 (2%)                                             
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
   Thymus                                             (49)         (47)         (47)         (50)                                   
      Thymoma Benign                                                             1 (2%)                                             
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (47)         (48)                                   
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                     3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Keratoacanthoma                                  2 (4%)       1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     5 (10%)      1 (2%)       6 (12%)      4 (8%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Melanoma Benign                          1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Malignant                       2 (4%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                    1 (2%)                                
   Skeletal Muscle                                    (4)          (1)          (1)                                                 
      Fibrosarcoma, Metastatic, Spleen                 1 (25%)                                                                      
      Histiocytic Sarcoma                              1 (25%)                                                                      
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (49)                                   
      Astrocytoma Malignant                                         1 (2%)                                                          
      Glioma Malignant                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (2)                                                 
      Carcinoma                                                                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Artery, Osteosarcoma, Metastatic, Bone                        1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)                                                                       
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
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 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            15 (30%)      5 (10%)      6 (12%)      6 (12%)                               
      Mesothelioma Malignant                           1 (2%)       2 (4%)       4 (8%)       3 (6%)                                
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                                                             Page  11                                                               
NTP Experiment-Test: 05067-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            THEOPHYLLINE                                       Date: 07/11/96  
Route: GAVAGE                                                                                                     Time: 17:04:03  
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         FISCHER 344 RATS MALE                     VEHICLE      7.5          25 MG/KG     75 MG/KG                                  
                                                   CONTROL      MG/KG                                                               
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          48          47                                       
     Total Primary Neoplasms                          134         118         106         100                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          48          46                                       
     Total Benign Neoplasms                           104          87          89          84                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          18          14          14                                       
     Total Malignant Neoplasms                         30          31          17          16                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                       1                                       
     Total Metastatic Neoplasm                          5           4                       1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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