National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2332

TDMS Study 05068-10 Pathology Tables

NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 00:31:23




       Facility:  Microbiological Associates

       Chemical CAS #:  76-57-3

       Lock Date:  03/03/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10            9            9            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9            6            4                                     
    Natural Death                                      7            6            2           11                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           36           43           34                                     
    Natural Death                                      1                                      1                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    60           60           60           59                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (60)         (60)         (59)         (58)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
   Intestine Large, Cecum                             (60)         (58)         (60)         (58)                                   
   Intestine Small, Duodenum                          (58)         (58)         (57)         (57)                                   
   Intestine Small, Jejunum                           (60)         (57)         (59)         (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Small, Ileum                             (58)         (57)         (57)         (57)                                   
   Liver                                              (60)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         5 (8%)       7 (12%)      6 (10%)      3 (5%)                                
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Adenoma                           9 (15%)     10 (17%)     11 (18%)      4 (7%)                                
      Hepatocellular Adenoma, Multiple                 5 (8%)       1 (2%)       2 (3%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (3%)                    1 (2%)                                
   Mesentery                                          (10)         (9)          (7)          (5)                                    
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (20%)                               
      Fibrosarcoma                                                  1 (11%)                                                         
      Hemangioma                                                    1 (11%)                                                         
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Acinar Cell, Adenocarcinoma                                                             1 (2%)                                
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (59)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (59)         (58)                                   
   Heart                                              (60)         (60)         (60)         (59)                                   
      Osteosarcoma, Metastatic, Skin                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (59)                                   
      Adenoma                                                                    1 (2%)                                             
      Extra Adrenal Tissue, Adenocarcinoma,                                                                                         
          Metastatic, Pancreas                                                                1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (59)                                   
      Adenoma                                          1 (2%)       2 (3%)       1 (2%)                                             
   Pituitary Gland                                    (58)         (56)         (58)         (55)                                   
      Pars Distalis, Adenoma                          11 (19%)      9 (16%)     17 (29%)     10 (18%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
   Thyroid Gland                                      (58)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)       4 (7%)       3 (5%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (58)         (60)         (59)         (59)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
      Adenoma                                          2 (3%)       3 (5%)                    2 (3%)                                
      Cystadenoma                                                                             1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Teratoma Malignant                                                                      1 (2%)                                
   Uterus                                             (60)         (60)         (59)         (59)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    4 (7%)                    2 (3%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________

                                                             Page   3                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (4)          (2)          (2)          (9)                                    
      Histiocytic Sarcoma                              1 (25%)                                                                      
      Teratoma Malignant, Metastatic                                                          1 (11%)                               
      Mediastinal, Histiocytic Sarcoma                              1 (50%)                   1 (11%)                               
   Lymph Node, Mandibular                             (54)         (55)         (58)         (56)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (57)         (56)         (57)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                    1 (2%)                                
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                    1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (58)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Thymus                                             (48)         (50)         (56)         (51)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (60)         (59)         (59)                                   
      Carcinoma                                                                  2 (3%)       2 (3%)                                
   Skin                                               (60)         (60)         (60)         (59)                                   
      Subcutaneous Tissue, Fibrosarcoma                             2 (3%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Osteosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (59)                                   
      Chondrosarcoma                                                             1 (2%)                                             
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (1)          (1)                                    
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (100%)                              
      Hemangiosarcoma                                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________

                                                             Page   4                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
      Alveolar/Bronchiolar Adenoma                     3 (5%)       3 (5%)       5 (8%)       4 (7%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             3 (5%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (3%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Mediastinum, Osteosarcoma, Metastatic, Skin                   1 (2%)                                                          
   Nose                                               (60)         (60)         (59)         (59)                                   
   Trachea                                            (60)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (4)          (3)          (3)                                    
      Adenoma                                          1 (50%)      2 (50%)      1 (33%)      2 (67%)                               
      Carcinoma                                                     1 (25%)                                                         
      Bilateral, Adenoma                                            1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                    1 (2%)                                                          
   Urinary Bladder                                    (60)         (59)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Pancreas                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(59)                                   
      Histiocytic Sarcoma                              2 (3%)       2 (3%)                    1 (2%)                                
      Lymphoma Malignant Lymphocytic                   2 (3%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         6 (10%)      4 (7%)       6 (10%)      8 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          39          38          31                                       
     Total Primary Neoplasms                           57          63          69          48                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          27          33          19                                       
     Total Benign Neoplasms                            39          37          48          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          24          17          19                                       
     Total Malignant Neoplasms                         18          26          21          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          3                       5                                       
     Total Metastatic Neoplasm                                      7                      14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            4            2            1                                     
    Natural Death                                      5            7            3            6                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           38           45           43                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (50)         (50)         (50)                                   
   Intestine Large, Cecum                             (60)         (60)         (60)         (58)                                   
   Intestine Small, Duodenum                          (59)         (60)         (59)         (58)                                   
   Intestine Small, Jejunum                           (60)         (60)         (59)         (58)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (59)         (60)         (59)         (57)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                        10 (17%)      8 (13%)     13 (22%)      8 (13%)                               
      Hepatocellular Carcinoma, Multiple               3 (5%)                                                                       
      Hepatocellular Adenoma                          15 (25%)     16 (27%)     13 (22%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                11 (18%)     10 (17%)      5 (8%)       1 (2%)                                
   Mesentery                                          (1)          (3)          (3)          (2)                                    
      Histiocytic Sarcoma                                                                     1 (50%)                               
   Pancreas                                           (59)         (60)         (60)         (60)                                   
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (59)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (59)         (60)         (60)         (60)                                   
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (58)         (60)         (60)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Subcapsular, Adenoma                                          1 (2%)                                                          
   Adrenal Medulla                                    (59)         (57)         (58)         (59)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)       1 (2%)                                                          
   Pituitary Gland                                    (56)         (59)         (58)         (55)                                   
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
   Prostate                                           (56)         (59)         (58)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (60)         (59)                                   
      Adenoma                                          1 (2%)                                                                       
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Fibroma, Osseous                                                                        1 (2%)                                
   Lymph Node                                         (6)          (1)                       (2)                                    
      Mediastinal, Histiocytic Sarcoma                              1 (100%)                                                        
   Lymph Node, Mandibular                             (48)         (53)         (56)         (55)                                   
   Lymph Node, Mesenteric                             (59)         (59)         (58)         (58)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Spleen                                             (60)         (60)         (58)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (53)         (44)         (52)         (54)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    12 (20%)      8 (13%)     13 (22%)      8 (13%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           4 (7%)                    1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       2 (3%)       3 (5%)       2 (3%)                                
   Nose                                               (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (5)          (3)                                    
      Adenoma                                          3 (100%)     3 (100%)     5 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           2 (3%)                    2 (3%)                                
      Lymphoma Malignant Lymphocytic                   3 (5%)                                                                       
      Lymphoma Malignant Mixed                         4 (7%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   9                                                               
NTP Experiment-Test: 05068-10  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 00:31:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        750 PPM      1500 PPM     3000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          40          38          32                                       
     Total Primary Neoplasms                           75          59          57          39                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          33          32          24                                       
     Total Benign Neoplasms                            49          43          40          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          15          15          11                                       
     Total Malignant Neoplasms                         26          16          17          12                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           3           2                                       
     Total Metastatic Neoplasm                          4           3           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  10                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.