TDMS Study 05068-10 Pathology Tables
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
Facility: Microbiological Associates
Chemical CAS #: 76-57-3
Lock Date: 03/03/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 9 9
Early Deaths
Moribund Sacrifice 7 9 6 4
Natural Death 7 6 2 11
Survivors
Terminal Sacrifice 35 36 43 34
Natural Death 1 1
Missing 1
Animals Examined Microscopically 60 60 60 59
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ALIMENTARY SYSTEM
Intestine Large, Rectum (60) (60) (59) (58)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Intestine Large, Cecum (60) (58) (60) (58)
Intestine Small, Duodenum (58) (58) (57) (57)
Intestine Small, Jejunum (60) (57) (59) (59)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Ileum (58) (57) (57) (57)
Liver (60) (60) (60) (59)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 5 (8%) 7 (12%) 6 (10%) 3 (5%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 9 (15%) 10 (17%) 11 (18%) 4 (7%)
Hepatocellular Adenoma, Multiple 5 (8%) 1 (2%) 2 (3%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (3%) 1 (2%)
Mesentery (10) (9) (7) (5)
Adenocarcinoma, Metastatic, Pancreas 1 (20%)
Fibrosarcoma 1 (11%)
Hemangioma 1 (11%)
Pancreas (60) (60) (60) (59)
Histiocytic Sarcoma 1 (2%)
Acinar Cell, Adenocarcinoma 1 (2%)
Salivary Glands (60) (59) (60) (59)
Stomach, Forestomach (60) (60) (60) (59)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (60) (60) (60) (58)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60) (59) (58)
Heart (60) (60) (60) (59)
Osteosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (59) (59)
Adenoma 1 (2%)
Extra Adrenal Tissue, Adenocarcinoma,
Metastatic, Pancreas 1 (2%)
Islets, Pancreatic (60) (60) (60) (59)
Adenoma 1 (2%) 2 (3%) 1 (2%)
Pituitary Gland (58) (56) (58) (55)
Pars Distalis, Adenoma 11 (19%) 9 (16%) 17 (29%) 10 (18%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 3 (5%) 1 (2%)
Thyroid Gland (58) (60) (60) (59)
Histiocytic Sarcoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 4 (7%) 3 (5%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (58) (60) (59) (59)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Adenoma 2 (3%) 3 (5%) 2 (3%)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Teratoma Malignant 1 (2%)
Uterus (60) (60) (59) (59)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 4 (7%) 2 (3%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (59)
Histiocytic Sarcoma 1 (2%)
Lymph Node (4) (2) (2) (9)
Histiocytic Sarcoma 1 (25%)
Teratoma Malignant, Metastatic 1 (11%)
Mediastinal, Histiocytic Sarcoma 1 (50%) 1 (11%)
Lymph Node, Mandibular (54) (55) (58) (56)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (57) (56) (57)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Spleen (60) (60) (60) (58)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Thymus (48) (50) (56) (51)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (60) (59) (59)
Carcinoma 2 (3%) 2 (3%)
Skin (60) (60) (60) (59)
Subcutaneous Tissue, Fibrosarcoma 2 (3%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 2 (3%) 1 (2%) 2 (3%)
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MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (59)
Chondrosarcoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Adenocarcinoma, Metastatic, Pancreas 1 (100%)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (59)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Alveolar/Bronchiolar Adenoma 3 (5%) 3 (5%) 5 (8%) 4 (7%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (5%)
Histiocytic Sarcoma 1 (2%) 2 (3%) 1 (2%)
Osteosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Osteosarcoma, Metastatic, Skin 1 (2%)
Nose (60) (60) (59) (59)
Trachea (60) (60) (60) (59)
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SPECIAL SENSES SYSTEM
Harderian Gland (2) (4) (3) (3)
Adenoma 1 (50%) 2 (50%) 1 (33%) 2 (67%)
Carcinoma 1 (25%)
Bilateral, Adenoma 1 (25%)
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URINARY SYSTEM
Kidney (60) (60) (60) (59)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Urinary Bladder (60) (59) (60) (59)
Adenocarcinoma, Metastatic, Pancreas 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(59)
Histiocytic Sarcoma 2 (3%) 2 (3%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%) 1 (2%)
Lymphoma Malignant Mixed 6 (10%) 4 (7%) 6 (10%) 8 (14%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 39 38 31
Total Primary Neoplasms 57 63 69 48
Total Animals with Benign Neoplasms 30 27 33 19
Total Benign Neoplasms 39 37 48 27
Total Animals with Malignant Neoplasms 16 24 17 19
Total Malignant Neoplasms 18 26 21 21
Total Animals with Metastatic Neoplasms 3 5
Total Metastatic Neoplasm 7 14
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 4 4 2 1
Natural Death 5 7 3 6
Accidently Killed 1
Survivors
Terminal Sacrifice 41 38 45 43
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (50) (50) (50)
Intestine Large, Cecum (60) (60) (60) (58)
Intestine Small, Duodenum (59) (60) (59) (58)
Intestine Small, Jejunum (60) (60) (59) (58)
Carcinoma 1 (2%)
Intestine Small, Ileum (59) (60) (59) (57)
Liver (60) (60) (60) (60)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 10 (17%) 8 (13%) 13 (22%) 8 (13%)
Hepatocellular Carcinoma, Multiple 3 (5%)
Hepatocellular Adenoma 15 (25%) 16 (27%) 13 (22%) 10 (17%)
Hepatocellular Adenoma, Multiple 11 (18%) 10 (17%) 5 (8%) 1 (2%)
Mesentery (1) (3) (3) (2)
Histiocytic Sarcoma 1 (50%)
Pancreas (59) (60) (60) (60)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (60) (60) (60) (60)
Stomach, Glandular (59) (60) (60) (59)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (59) (60) (60) (60)
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (60) (60)
Adenoma 1 (2%) 1 (2%)
Subcapsular, Adenoma 1 (2%)
Adrenal Medulla (59) (57) (58) (59)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (60) (60) (60)
Adenoma 2 (3%) 1 (2%)
Pituitary Gland (56) (59) (58) (55)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (59) (60) (60) (60)
Follicular Cell, Adenoma 1 (2%) 2 (3%) 1 (2%) 2 (3%)
Follicular Cell, Adenoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Prostate (56) (59) (58) (60)
Seminal Vesicle (60) (60) (60) (59)
Adenoma 1 (2%)
Testes (60) (60) (60) (60)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Fibroma, Osseous 1 (2%)
Lymph Node (6) (1) (2)
Mediastinal, Histiocytic Sarcoma 1 (100%)
Lymph Node, Mandibular (48) (53) (56) (55)
Lymph Node, Mesenteric (59) (59) (58) (58)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Spleen (60) (60) (58) (60)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (53) (44) (52) (54)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60) (60)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 12 (20%) 8 (13%) 13 (22%) 8 (13%)
Alveolar/Bronchiolar Adenoma, Multiple 4 (7%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (3%) 2 (3%) 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 4 (7%) 2 (3%) 3 (5%) 2 (3%)
Nose (60) (60) (59) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (3) (5) (3)
Adenoma 3 (100%) 3 (100%) 5 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Urinary Bladder (60) (60) (60) (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 2 (3%) 2 (3%)
Lymphoma Malignant Lymphocytic 3 (5%)
Lymphoma Malignant Mixed 4 (7%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05068-10 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CODEINE Date: 04/03/96
Route: DOSED FEED Time: 00:31:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 750 PPM 1500 PPM 3000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 44 40 38 32
Total Primary Neoplasms 75 59 57 39
Total Animals with Benign Neoplasms 37 33 32 24
Total Benign Neoplasms 49 43 40 27
Total Animals with Malignant Neoplasms 20 15 15 11
Total Malignant Neoplasms 26 16 17 12
Total Animals with Metastatic Neoplasms 4 2 3 2
Total Metastatic Neoplasm 4 3 3 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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