TDMS Study 05068-10 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL CODEINE NTP Experiment-Test: 05068-10 Report: PEIRPT09 Study Type: CHRONIC Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 CORE STUDY Facility: Microbiological Associates Chemical CAS #: 76-57-3 Lock Date: 03/03/92 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25023 Missing 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + M + + + M + + + M + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Eosinophilic Focus | 3 X X X | Hematopoietic Cell Proliferation | 3 2 | Inflammation, Chronic Active | 1 2 4 1 | Necrosis | 2 | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + + | Inflammation, Chronic Active | 3 2 | Fat, Necrosis | 4 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | 2 2 | Acinar Cell, Atrophy | 2 4 | Acinar Cell, Depletion Secretory | | Duct, Cyst | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 3| Inflammation, Chronic Active | 1 2 2| Necrosis | 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 | Subcapsular, Hyperplasia | 2 2 2 1 1 1 1 1 1 1 2 1 2 2 2 1 3 1 2 2 1 1| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + M + + M + + M M M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + M + + + + + + + + + +| Pars Distalis, Angiectasis | 3 | Pars Distalis, Hyperplasia | 1 4 1 2 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Follicle, Cyst | 1 | Follicular Cell, Hyperplasia, Focal | 1 4 1 1 1 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M M + M + + M + + + + + + + + + + + + + + + + M| Dilatation | 2 1 2 2 3 3 3 3 2 3 2 2 2 2 3 3 2 | Inflammation, Chronic Active | 1 1 1 | Pigmentation | 1 | __________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| Abscess | 4 | Cyst | 2 | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Oviduct | + + | Cyst | 3 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 4 4 4 3 4 4 | Hyperplasia, Cystic | 3 2 2 1 1 2 4 2 3 3 2 3 1 2 3 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 3 | __________________________________________________________________________| Lymph Node | + + | Iliac, Inflammation, Chronic Active | | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + M + M + + + + + + + + + +| Hemorrhage | 1 2 | __________________________________________________________________________| Lymph Node, Mesenteric | I + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hemorrhage | 2 2 1 | Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 4 4 4 4 1 3 2 1 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia, Lymphoid | 2 | Pigmentation, Hemosiderin | 1 | Capsule, Inflammation, Chronic Active| 4 | __________________________________________________________________________| Thymus | + M + M + + M M M I + M + M M + + + + + M + + + +| Atrophy | 3 | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Inflammation, Chronic Active | 2 2 | Ulcer | | Epidermis, Hyperplasia | | Subcutaneous Tissue, Abscess | 4 | Subcutaneous Tissue, Inflammation, | | Chronic Active | | Subcutaneous Tissue, Pigmentation | | Subcutaneous Tissue, Fat, Atrophy | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 2 2 2 1 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 2 | Hemorrhage | 1 | Mineralization | 2 1 1 1 1 2 2 1 3 2 1| Meninges, Inflammation, Chronic | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 | Infiltration Cellular, Histiocyte | 1 | Pigmentation, Hemosiderin | 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 1 1 2 1 2 2 2 2 | Respiratory Epithelium, Hyperplasia, | | Glandular | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Glomerulosclerosis | 2 | Infarct | 1 | Inflammation, Chronic | 1 2 1 1 | Metaplasia, Osseous | 2 | Renal Tubule, Degeneration, Hyaline | 2 | Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 2 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + + + + + + + A + + + + + + M +| 43 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + M + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Eosinophilic Focus | 2 1 | 6 2.0| Hematopoietic Cell Proliferation | 1 | 3 2.0| Inflammation, Chronic Active | 1 1 1 | 7 1.6| Necrosis | 1 | 2 1.5| Centrilobular, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 9 | Inflammation, Chronic Active | | 2 2.5| Fat, Necrosis | 4 4 | 5 3.4| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| Inflammation, Chronic Active | | 2 2.0| Acinar Cell, Atrophy | | 2 3.0| Acinar Cell, Depletion Secretory | 3 | 1 3.0| Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 3 1 2 2 1 1 1 2 | 28 1.2| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 1 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia | | 1 3.0| Inflammation, Chronic Active | | 3 1.7| Necrosis | | 2 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytoplasmic Alteration, Focal | | 1 2.0| Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 3 2 1 1 2 1 1 1| 47 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + M + M + + M + + M + M + + + + + + + M| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | 2 | 2 2.5| Pars Distalis, Hyperplasia | 1 1 1 2 2 2 2| 11 1.7| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + M + I + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 2 1.5| Follicle, Cyst | 1 3 | 3 1.7| Follicular Cell, Hyperplasia, Focal | 1 1 3 1 1 1 | 14 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + M + + + M + + M + + + + M| 41 | Dilatation | 3 3 1 2 2 3 2 2 2 3 2 1 2 2 1 3 3 | 34 2.3| Inflammation, Chronic Active | | 3 1.0| Pigmentation | 1 2 | 3 1.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | | 1 4.0| Cyst | 4 4 2 4 | 5 3.2| Inflammation, Chronic Active | 3 | 2 3.5| __________________________________________________________________________|____________| Oviduct | + | 3 | Cyst | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 4 4 | 10 3.9| Hyperplasia, Cystic | 2 2 2 3 3 3 3 2 3 1 1 2 2 2 2 3 2 3 2| 36 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 3 2 | 4 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Iliac, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + M| 45 | Hemorrhage | | 2 1.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | 1 | 4 1.5| Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 3 1 1 4 4 2 1 | 17 2.6| Hyperplasia, Lymphoid | | 1 2.0| Pigmentation, Hemosiderin | | 1 1.0| Capsule, Inflammation, Chronic Active| | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + M +| 38 | Atrophy | 3 2 2 4 | 5 2.8| Hyperplasia, Lymphoid | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + M + + + + + + + + + + M M + +| 45 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | X | 1 | Inflammation, Chronic Active | 3 | 3 2.3| Ulcer | 2 | 1 2.0| Epidermis, Hyperplasia | 3 | 1 3.0| Subcutaneous Tissue, Abscess | | 1 4.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | 3 | 1 3.0| Subcutaneous Tissue, Pigmentation | 2 | 1 2.0| Subcutaneous Tissue, Fat, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia | 1 1 2 1 1 3 | 11 1.6| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | 3 4 | 3 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | | 1 1.0| Mineralization | 1 1 2 2 1 1 2 1 1 1 1 1 | 23 1.4| Meninges, Inflammation, Chronic | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 29 1.0| Infiltration Cellular, Histiocyte | | 1 1.0| Pigmentation, Hemosiderin | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 1 2 2 2 1 2 1 1 3 2 2 1 2 | 27 1.7| Respiratory Epithelium, Hyperplasia, | | | Glandular | 2 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | Hyperplasia, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 4 | 1 4.0| Glomerulosclerosis | | 1 2.0| Infarct | | 1 1.0| Inflammation, Chronic | 1 1 1 1 1 | 9 1.1| Metaplasia, Osseous | | 1 2.0| Renal Tubule, Degeneration, Hyaline | | 1 2.0| Renal Tubule, Regeneration | 1 1 1 1 1 1 1 | 19 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4| | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + M + + + + M + + + + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | M + + + + + + + + A + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Eosinophilic Focus | X 4 1 2 | Hematopoietic Cell Proliferation | 2 3 | Inflammation, Chronic Active | 1 | Mitotic Alteration | | Necrosis | 4 3| Hepatocyte, Necrosis | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 1 4 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 1 1 | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Mineralization | 1 | Thrombosis | | Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 3 1| Subcapsular, Hyperplasia | 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 2 2 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4| | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + M + + + M + + + M + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | 1 | Pars Distalis, Hyperplasia | 2 1 3 2 2 3 4 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 | Follicle, Cyst | | Follicular Cell, Hyperplasia, Focal | 2 1 2 1 2 3 1 1 1 1 2 2 2 1 2 4 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + M + + + + +| Dilatation | 4 2 1 2 2 1 1 3 2 2 2 2 2 3 3 2 3 3 2 2 2 | Inflammation, Chronic Active | 1 3 1| Pigmentation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 3 1 4 4 2 2 | __________________________________________________________________________| Oviduct | | Dilatation | | Inflammation, Chronic Active | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 2 4 4 4 4 | Hemorrhage | 2 | Hyperplasia, Cystic | 2 2 3 2 3 2 3 1 2 2 3 3 3 2 2 3 4 2 1 2 1 3 1| Inflammation, Chronic Active | 2 | Lymphatic, Ectasia | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Congestion | | Myeloid Cell, Hyperplasia | 3 3 | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| Cyst | | Fibrosis | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4| | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 | Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 4 1 3 1 1 4 1 4| Hyperplasia, Lymphoid | 2 2 | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Thymus | + M + + + + M + + M + + + + + + + + + M + M + M +| Atrophy | 2 4| Ectopic Parathyroid Gland | | Hyperplasia, Lymphoid | 3 1 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Epidermis, Hyperplasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 2 1 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Degeneration | | Mineralization | 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 2 | Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | 3| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 1 2 2 2 2 2 2 2 1 2 2 2 1 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4| | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 | Nephropathy | | Renal Tubule, Regeneration | 1 2 1 1 2 1 2 1 1 1 2 1 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 3 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3| | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + + + M M + + + + + + + + A + + + M + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + A + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Eosinophilic Focus | 3 1 1| Hematopoietic Cell Proliferation | 1 1 1 | Inflammation, Chronic Active | 1 1 1 2 1 1| Mitotic Alteration | 2 | Necrosis | | Hepatocyte, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis | 3 3 4 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | 4 | Duct, Cyst | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 1 2 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 1 | Necrosis | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 1 | Mineralization | | Thrombosis | 3 1 | Artery, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hematopoietic Cell Proliferation | | Subcapsular, Hyperplasia | 1 1 1 1 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3| | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M M M M M + + M + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + M + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 | Follicle, Cyst | | Follicular Cell, Hyperplasia, Focal | 1 1 1 2 1 1 1 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + M + + + M + + + M + M + + + + + + + +| Dilatation | 3 2 2 3 2 2 1 2 3 2 2 3 2 3 2 3 1 3| Inflammation, Chronic Active | 1 | Pigmentation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 2 | __________________________________________________________________________| Oviduct | + | Dilatation | 3 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 3 4 3 | Hemorrhage | 3 | Hyperplasia, Cystic | 3 1 2 1 2 1 4 2 4 1 1 1 4 1 2 1 2| Inflammation, Chronic Active | | Lymphatic, Ectasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2| Congestion | 3 | Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + M + + M + M + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + M + + + + + + + + + + + + + + + + + +| Cyst | 3 4 | Fibrosis | 4 | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3| | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Hemorrhage | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 3 4 4 4 4 2 3 2 4 4 | Hyperplasia, Lymphoid | 2 2 | Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Thymus | + + M + + + M + + + + + M + + + + + + + + M + + +| Atrophy | 4 2 3 2 4 4 4 | Ectopic Parathyroid Gland | X | Hyperplasia, Lymphoid | 2 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Epidermis, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 1 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 2 | Degeneration | 2 | Mineralization | 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage | | Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 1 1 2 2 1 1 1 2 2 2 2 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3| | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 | Nephropathy | 2 2 1 | Renal Tubule, Regeneration | 1 1 1 2 2 1 1 1 2 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 2 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 3| | A | 750 PPM | 6| | L | | 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 50 | __________________________________________________________________________|____________| Gallbladder | + | 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 51 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 51 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 48 | Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + | 48 | __________________________________________________________________________|____________| Liver | + | 51 | Cyst | | 1 2.0| Eosinophilic Focus | | 7 2.0| Hematopoietic Cell Proliferation | | 5 1.6| Inflammation, Chronic Active | | 7 1.1| Mitotic Alteration | | 1 2.0| Necrosis | | 2 3.5| Hepatocyte, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 9 | Fat, Necrosis | | 8 2.8| __________________________________________________________________________|____________| Pancreas | + | 51 | Acinar Cell, Atrophy | | 1 4.0| Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + | 50 | Inflammation, Chronic | | 28 1.2| __________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + | 51 | Inflammation, Chronic Active | | 9 1.0| Necrosis | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 51 | __________________________________________________________________________|____________| Heart | + | 51 | Fibrosis | | 2 1.0| Mineralization | | 1 1.0| Thrombosis | | 2 2.0| Artery, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 3| | A | 750 PPM | 6| | L | | 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 51 | Angiectasis | | 1 3.0| Hematopoietic Cell Proliferation | | 2 2.0| Subcapsular, Hyperplasia | 2 | 46 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 51 | __________________________________________________________________________|____________| Parathyroid Gland | + | 39 | __________________________________________________________________________|____________| Pituitary Gland | + | 47 | Pars Distalis, Angiectasis | | 1 2.0| Pars Distalis, Cyst | | 1 1.0| Pars Distalis, Hyperplasia | | 12 2.1| __________________________________________________________________________|____________| Thyroid Gland | + | 51 | Inflammation, Chronic Active | | 6 1.0| Follicle, Cyst | 2 | 1 2.0| Follicular Cell, Hyperplasia, Focal | 2 | 29 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M | 43 | Dilatation | | 39 2.2| Inflammation, Chronic Active | | 4 1.5| Pigmentation | | 2 2.0| __________________________________________________________________________|____________| Ovary | + | 51 | Cyst | | 11 2.6| __________________________________________________________________________|____________| Oviduct | | 1 | Dilatation | | 1 3.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Uterus | + | 51 | Dilatation | | 10 3.6| Hemorrhage | | 2 2.5| Hyperplasia, Cystic | 3 | 41 2.1| Inflammation, Chronic Active | | 1 2.0| Lymphatic, Ectasia | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + | 51 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 3| | A | 750 PPM | 6| | L | | 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Atrophy | | 1 2.0| Congestion | | 1 3.0| Myeloid Cell, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Lymph Node | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 46 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 48 | Cyst | | 2 3.5| Fibrosis | | 1 4.0| Hematopoietic Cell Proliferation | | 1 3.0| Hemorrhage | | 2 1.5| __________________________________________________________________________|____________| Spleen | + | 51 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 19 2.9| Hyperplasia, Lymphoid | | 4 2.0| Infiltration Cellular, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Thymus | + | 41 | Atrophy | | 9 3.2| Ectopic Parathyroid Gland | | 1 | Hyperplasia, Lymphoid | | 5 1.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 51 | __________________________________________________________________________|____________| Skin | + | 51 | Inflammation, Chronic Active | | 2 3.0| Epidermis, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 51 | Dysplasia | | 5 1.6| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 51 | Compression | | 1 2.0| Degeneration | | 1 2.0| Mineralization | 1 | 18 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 3| | A | 750 PPM | 6| | L | | 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + | 51 | Congestion | | 1 2.0| Hemorrhage | | 1 2.0| Infiltration Cellular, Lymphocyte | 1 | 22 1.1| Alveolar Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Nose | + | 51 | Olfactory Epithelium, Degeneration, | | | Hyaline | | 32 1.7| __________________________________________________________________________|____________| Trachea | + | 51 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 51 | Inflammation, Chronic | 1 | 12 1.0| Nephropathy | | 3 1.7| Renal Tubule, Regeneration | 2 | 27 1.3| __________________________________________________________________________|____________| Urinary Bladder | + | 50 | Infiltration Cellular, Lymphocyte | 1 | 38 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + M + M + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | Ulcer | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Basophilic Focus | 3 | Clear Cell Focus | X | Cyst | 3 3 | Eosinophilic Focus | 3 X 4 | Fatty Change, Focal | | Infarct | 4 2 | Inflammation, Chronic Active | 1 1 1 1 | Mineralization | 2 | Mixed Cell Focus | X | Necrosis | | Bile Duct, Hyperplasia | 2 | Centrilobular, Inflammation, Chronic | | Centrilobular, Pigmentation | | __________________________________________________________________________| Mesentery | + + +| Artery, Inflammation, Chronic Active | 4| Fat, Necrosis | 2 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinar Cell, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 4| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +| Cyst | 2 | Hypertrophy, Focal | | Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 2 2 1 1 1 1 2 2 2 1 2 1 1 2 1 2 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M M + + M + + + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Craniopharyngeal Duct, Hyperplasia | 2 | Pars Distalis, Hyperplasia | 2 1 1 1 3 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 1 1 1 2 1| Follicle, Cyst | 1 3 1 | Follicular Cell, Hyperplasia, Diffuse| 4 | Follicular Cell, Hyperplasia, Focal | 3 1 2 2 1 2 2 1 1 1 2 2 1 2 2 1 1 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + M + + + + + + + M + + + M + + + + + +| Dilatation | 2 2 2 3 3 3 2 3 3 3 2 2 3 2 2 2 3 2 3 2 2| Inflammation, Chronic Active | 1 1 1 1 | Pigmentation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 2 4 2 4 4 | Hemorrhage | | Infiltration Cellular, Histiocyte | 3 3 | Periovarian Tissue, Infiltration | | Cellular, Lymphocyte | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Dilatation | 4 3 4 2 4 | Hyperplasia, Cystic | 2 3 1 1 1 3 3 3 4 2 3 3 2 3 1 4 3 4 3 4 2| Cervix, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Myeloid Cell, Hyperplasia | 3| __________________________________________________________________________| Lymph Node | +| _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Iliac, Hyperplasia, Lymphoid | 3| Inguinal, Pigmentation | 1| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| Hematopoietic Cell Proliferation | 2 2 | Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Fibrosis | 2 | Hematopoietic Cell Proliferation | 1 1 2 2 1 2 2 4 2| Hyperplasia, Lymphoid | 2 2 2 | Pigmentation, Hemosiderin | 2 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + M + + + + + M + + +| Atrophy | 3 2 | Ectopic Thyroid | | Hyperplasia, Lymphoid | 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 4 1 | Epidermis, Hyperplasia | 2 | Subcutaneous Tissue, Fat, Atrophy | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 2 2 2 1 | Fracture | X | Artery, Inflammation, Chronic Active | 3| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Infiltration Cellular, Histiocyte | 2| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | Artery, Inflammation, Chronic Active | 2| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2| | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + M + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 2 1 2 2 2 1 1 2 2 1 2 2 2 2 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | +| __________________________________________________________________________| Eye | + | Atrophy | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Harderian Gland | + | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Inflammation, Chronic | 1 1 1 1 | Nephropathy | 3 2 | Renal Tubule, Karyomegaly | 2 | Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Ureter | + | Infiltration Cellular, Lymphocyte | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | Artery, Inflammation, Chronic Active | 1| _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + A + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Basophilic Focus | | Clear Cell Focus | | Cyst | | Eosinophilic Focus | 2 3 X X 1 4 | Fatty Change, Focal | 2 | Infarct | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1| Mineralization | | Mixed Cell Focus | X | Necrosis | 1 1 | Bile Duct, Hyperplasia | | Centrilobular, Inflammation, Chronic | 2 | Centrilobular, Pigmentation | 2 | __________________________________________________________________________| Mesentery | + + + +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | 4 4 4 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Acinar Cell, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +| Aorta, Inflammation, Chronic Active | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hypertrophy, Focal | 1 | Subcapsular, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + M + M M M + + + + + + M + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Craniopharyngeal Duct, Hyperplasia | | Pars Distalis, Hyperplasia | 3 1 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Follicle, Cyst | 1 2 | Follicular Cell, Hyperplasia, Diffuse| | Follicular Cell, Hyperplasia, Focal | 2 1 1 3 1 2 3 3 2 2 1 1 1 4 1 2 2 2 1 2 4| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + M + + + + + +| Dilatation | 3 2 2 2 3 3 2 1 3 2 3 1 3 3 2 2 3 2 | Inflammation, Chronic Active | 1 | Pigmentation | 2 2 | __________________________________________________________________________| Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 4 1 1 2 | Hemorrhage | 2 | Infiltration Cellular, Histiocyte | | Periovarian Tissue, Infiltration | | Cellular, Lymphocyte | | __________________________________________________________________________| Uterus | + + + + M + + + + + + + + + + + + + + + + + + + +| Atrophy | | Dilatation | 4 4 4 4 | Hyperplasia, Cystic | 1 2 3 1 2 3 2 2 4 2 4 2 1 4 2 2 | Cervix, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Iliac, Hyperplasia, Lymphoid | | Inguinal, Pigmentation | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia, Lymphoid | 2 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + M + + + + +| Hematopoietic Cell Proliferation | | Hemorrhage | | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Fibrosis | | Hematopoietic Cell Proliferation | 3 2 2 4 2 2 3 2 2 | Hyperplasia, Lymphoid | 2 2 2| Pigmentation, Hemosiderin | 2 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 | Ectopic Thyroid | X | Hyperplasia, Lymphoid | 4 2 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 1 | Epidermis, Hyperplasia | | Subcutaneous Tissue, Fat, Atrophy | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 2 1 1 2 | Fracture | | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 2| Infiltration Cellular, Histiocyte | | Mineralization | 1 1 1 1 2 1 1 1 1 | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 3 2 2 1 1 1 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Atrophy | 4 | Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | + + | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 1 | Inflammation, Chronic | 1 1 1 1 | Nephropathy | | Renal Tubule, Karyomegaly | | Renal Tubule, Regeneration | 1 1 1 2 1 2 1 1 1 2 1 1| __________________________________________________________________________| Ureter | | Infiltration Cellular, Lymphocyte | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 1500 PPM | 2| | L | | 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 49 | __________________________________________________________________________|____________| Gallbladder | + | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 51 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 51 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 48 | Ulcer | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + | 48 | __________________________________________________________________________|____________| Liver | + | 51 | Atrophy | | 1 3.0| Basophilic Focus | | 1 3.0| Clear Cell Focus | | 1 | Cyst | | 2 3.0| Eosinophilic Focus | | 9 2.8| Fatty Change, Focal | | 1 2.0| Infarct | | 2 3.0| Inflammation, Chronic Active | | 12 1.0| Mineralization | | 1 2.0| Mixed Cell Focus | | 2 | Necrosis | | 2 1.0| Bile Duct, Hyperplasia | | 1 2.0| Centrilobular, Inflammation, Chronic | | 1 2.0| Centrilobular, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 7 | Artery, Inflammation, Chronic Active | | 1 4.0| Fat, Necrosis | | 6 3.3| __________________________________________________________________________|____________| Pancreas | + | 51 | Inflammation, Chronic Active | | 1 2.0| Acinar Cell, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + | 51 | Inflammation, Chronic | 2 | 27 1.1| __________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | Hyperplasia | | 2 3.0| Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + | 51 | Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 1500 PPM | 2| | L | | 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 50 | Aorta, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Heart | + | 51 | Artery, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 50 | Cyst | | 1 2.0| Hypertrophy, Focal | | 1 1.0| Subcapsular, Hyperplasia | 1 | 49 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + | 50 | Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Islets, Pancreatic | + | 51 | __________________________________________________________________________|____________| Parathyroid Gland | + | 40 | __________________________________________________________________________|____________| Pituitary Gland | + | 49 | Craniopharyngeal Duct, Hyperplasia | | 1 2.0| Pars Distalis, Hyperplasia | | 11 1.9| __________________________________________________________________________|____________| Thyroid Gland | + | 51 | Inflammation, Chronic Active | | 10 1.2| Follicle, Cyst | | 5 1.6| Follicular Cell, Hyperplasia, Diffuse| | 1 4.0| Follicular Cell, Hyperplasia, Focal | 1 | 42 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 45 | Dilatation | 1 | 40 2.4| Inflammation, Chronic Active | | 5 1.0| Pigmentation | | 2 2.0| __________________________________________________________________________|____________| Ovary | + | 50 | Cyst | | 12 2.6| Hemorrhage | | 1 2.0| Infiltration Cellular, Histiocyte | | 2 3.0| Periovarian Tissue, Infiltration | | | Cellular, Lymphocyte | | 1 3.0| __________________________________________________________________________|____________| Uterus | + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 1500 PPM | 2| | L | | 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | | 1 3.0| Dilatation | | 9 3.7| Hyperplasia, Cystic | 4 | 38 2.5| Cervix, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 51 | Congestion | | 1 3.0| Myeloid Cell, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 2 | Iliac, Hyperplasia, Lymphoid | | 1 3.0| Inguinal, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 49 | Hyperplasia, Lymphoid | | 3 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 47 | Hematopoietic Cell Proliferation | | 2 2.0| Hemorrhage | | 1 2.0| Infiltration Cellular, Histiocyte | | 1 1.0| __________________________________________________________________________|____________| Spleen | + | 51 | Atrophy | | 1 3.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 18 2.2| Hyperplasia, Lymphoid | | 6 2.0| Pigmentation, Hemosiderin | | 2 2.0| __________________________________________________________________________|____________| Thymus | + | 47 | Atrophy | | 4 2.5| Ectopic Thyroid | | 1 | Hyperplasia, Lymphoid | | 7 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 50 | Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Skin | + | 51 | Inflammation, Chronic Active | | 6 2.2| Epidermis, Hyperplasia | | 1 2.0| Subcutaneous Tissue, Fat, Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 51 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 1500 PPM | 2| | L | | 0| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Dysplasia | | 8 1.6| Fracture | | 1 | Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 51 | Compression | | 3 3.3| Infiltration Cellular, Histiocyte | | 1 2.0| Mineralization | 1 | 21 1.0| Artery, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 51 | Infiltration Cellular, Lymphocyte | 1 | 24 1.1| Alveolar Epithelium, Hyperplasia | | 2 1.0| __________________________________________________________________________|____________| Nose | + | 50 | Olfactory Epithelium, Degeneration, | | | Hyaline | | 27 1.7| __________________________________________________________________________|____________| Trachea | + | 51 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 2 | Atrophy | | 1 4.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 3 | Inflammation, Chronic Active | | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 51 | Infarct | | 2 1.5| Inflammation, Chronic | | 8 1.0| Nephropathy | | 2 2.5| Renal Tubule, Karyomegaly | | 1 2.0| Renal Tubule, Regeneration | | 31 1.1| __________________________________________________________________________|____________| Ureter | | 1 | Infiltration Cellular, Lymphocyte | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 1500 PPM | 2| | L | | 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + | 51 | Infiltration Cellular, Lymphocyte | 1 | 37 1.1| Artery, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + M M + + + + + M + + + + + + M + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 1 | Congestion | | Eosinophilic Focus | 3 | Hematopoietic Cell Proliferation | 2 1 | Infarct | | Inflammation, Chronic Active | 1 1 | Mitotic Alteration | 2 | Mixed Cell Focus | X | Necrosis | 4 | Kupffer Cell, Hypertrophy | 4 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Acinar Cell, Atrophy | 3 4 | Duct, Cyst | 2 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Acute | | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Inflammation, Chronic Active | 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Inflammation, Chronic Active | 4 3 | Subcapsular, Hyperplasia | 1 2 2 2 2 1 1 2 1 1 2 2 2 2 2 1 1 1 1 2 1 2 1| __________________________________________________________________________| Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M M M + M + + M + + M + + + M M M + M M + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | 1 1 | Pars Distalis, Hyperplasia | 1 3 1 2 3 1 | Pars Intermedia, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Follicle, Cyst | 3 2 | Follicular Cell, Hyperplasia, Focal | 1 2 1 1 2 1 2 2 2 2 1 4 2 1 2 2 2 2 2 2 1 4 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + M + + + + + + + + + + + + +| Dilatation | 1 2 3 2 2 2 3 2 2 2 2 2 3 2 2 3 3 2 3 2 2 2| Inflammation, Chronic Active | 2 1 1 1 3 1 1| Pigmentation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 4 | Cyst | 1 | Inflammation, Chronic Active | 3 | Periovarian Tissue, Infiltration | | Cellular, Lymphocyte | | __________________________________________________________________________| Oviduct | + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 4 3 3| Hyperplasia, Cystic | 2 2 4 2 1 1 1 2 1 2 4 3 2 2 2 2 3 4 1 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + + + + | Mediastinal, Hyperplasia, Plasma Cell| 4 | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 1 2 3 2 4 2 4 3 | Hyperplasia, Lymphoid | 2 | Pigmentation, Hemosiderin | | Capsule, Inflammation, Chronic Active| 3 | __________________________________________________________________________| Thymus | M + + + + M + + M + + + + + + M M + + + + + + + +| Atrophy | 4 1 | Ectopic Parathyroid Gland | X | Hyperplasia, Lymphoid | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Epidermis, Hyperplasia | | Subcutaneous Tissue, Inflammation, | | Chronic Active | 3 | Subcutaneous Tissue, Fat, Atrophy | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 1 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 3 | Mineralization | 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + + | Inflammation, Chronic Active | 3 | Cornea, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Harderian Gland | + + | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hemorrhage | 4 | Hydronephrosis | | Infarct | 2 | Inflammation, Chronic | 1 1 1 1 1 1| Nephropathy | 1 | Capsule, Inflammation, Chronic Active| 2 | Glomerulus, Inflammation, Chronic | | Perirenal Tissue, Inflammation, | | Chronic Active | 3 | Renal Tubule, Degeneration, Hyaline | | Renal Tubule, Pigmentation | | Renal Tubule, Regeneration | 1 2 1 1 2 2 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + M M + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + A + M + M + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | | Congestion | 3 | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | 2 | Infarct | 4 | Inflammation, Chronic Active | 1 1| Mitotic Alteration | | Mixed Cell Focus | | Necrosis | 3 | Kupffer Cell, Hypertrophy | | __________________________________________________________________________| Mesentery | + + + + | Inflammation, Chronic Active | 4 | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4| Acinar Cell, Atrophy | | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Acute | | Inflammation, Chronic Active | 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 1 1 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Inflammation, Chronic Active | 3 | Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 2 2 2 1 1 2 1 1 1 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + M M M + + +| __________________________________________________________________________| Pituitary Gland | + + M + + + M + + M + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 3 2 2 3 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 2| Follicle, Cyst | 3 | Follicular Cell, Hyperplasia, Focal | 2 1 1 2 2 2 1 2 2 4 1 3 2 3 1 3 3 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + M + + + + + + + + M M + + + + + + + + + +| Dilatation | 2 2 2 2 2 2 3 3 1 3 3 3 2 2 3 2 3 2| Inflammation, Chronic Active | 2 1 1| Pigmentation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Cyst | 4 2 2 2 3 | Inflammation, Chronic Active | 4 | Periovarian Tissue, Infiltration | | Cellular, Lymphocyte | 3 | __________________________________________________________________________| Oviduct | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 4 4 | Hyperplasia, Cystic | 1 3 2 4 4 2 1 2 1 2 2 4 3 1 1 2 3 2| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + +| Mediastinal, Hyperplasia, Plasma Cell| | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 2 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 4 1 | Hyperplasia, Lymphoid | 2 1 | Pigmentation, Hemosiderin | 2 | Capsule, Inflammation, Chronic Active| | __________________________________________________________________________| Thymus | + + + M + + + + + + M + + M + + + + + + + + + +| Atrophy | 3 3 4 4 | Ectopic Parathyroid Gland | | Hyperplasia, Lymphoid | 1 1 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 2 | Epidermis, Hyperplasia | 1 | Subcutaneous Tissue, Inflammation, | | Chronic Active | | Subcutaneous Tissue, Fat, Atrophy | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 1 1 1 3 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Mineralization | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 2 2 1 2 2 2 2 3 2 1 2 2 1 2 2 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + | Inflammation, Chronic Active | 4 | Cornea, Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | + | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Hemorrhage | | Hydronephrosis | 1 | Infarct | 1 | Inflammation, Chronic | 1 1 1 1 1 1 1 | Nephropathy | | Capsule, Inflammation, Chronic Active| | Glomerulus, Inflammation, Chronic | 2 | Perirenal Tissue, Inflammation, | | Chronic Active | | Renal Tubule, Degeneration, Hyaline | 3 | Renal Tubule, Pigmentation | 2 | Renal Tubule, Regeneration | 1 1 1 1 1 1 2 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 3000 PPM | 7| | L | | 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 48 | __________________________________________________________________________|____________| Gallbladder | + | 41 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 50 | Hemorrhage | | 1 4.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + | 48 | __________________________________________________________________________|____________| Liver | + | 50 | Angiectasis | | 1 1.0| Basophilic Focus | | 1 1.0| Congestion | | 1 3.0| Eosinophilic Focus | | 2 3.0| Hematopoietic Cell Proliferation | | 3 1.7| Infarct | | 1 4.0| Inflammation, Chronic Active | | 4 1.0| Mitotic Alteration | | 1 2.0| Mixed Cell Focus | | 1 | Necrosis | | 2 3.5| Kupffer Cell, Hypertrophy | | 1 4.0| __________________________________________________________________________|____________| Mesentery | | 5 | Inflammation, Chronic Active | | 1 4.0| Fat, Necrosis | | 2 3.0| __________________________________________________________________________|____________| Pancreas | + | 50 | Inflammation, Chronic Active | | 2 3.5| Acinar Cell, Atrophy | | 2 3.5| Duct, Cyst | | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | + | 50 | Inflammation, Chronic | 1 | 23 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + | 50 | Hyperplasia | | 1 3.0| Inflammation, Acute | 1 | 1 1.0| Inflammation, Chronic Active | | 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + | 49 | Cyst | | 1 1.0| Inflammation, Chronic Active | | 6 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 3000 PPM | 7| | L | | 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 49 | __________________________________________________________________________|____________| Heart | + | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 50 | Angiectasis | | 1 3.0| Inflammation, Chronic Active | | 3 3.3| Subcapsular, Hyperplasia | 1 | 45 1.4| __________________________________________________________________________|____________| Adrenal Medulla | M | 48 | Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + | 33 | __________________________________________________________________________|____________| Pituitary Gland | + | 46 | Pars Distalis, Angiectasis | | 2 2.0| Pars Distalis, Cyst | | 2 1.0| Pars Distalis, Hyperplasia | | 10 2.1| Pars Intermedia, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + | 50 | Inflammation, Chronic Active | | 4 1.3| Follicle, Cyst | | 3 2.7| Follicular Cell, Hyperplasia, Focal | 2 | 44 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 44 | Dilatation | 3 | 41 2.3| Inflammation, Chronic Active | | 10 1.4| Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Ovary | + | 50 | Abscess | | 3 4.0| Cyst | | 6 2.3| Inflammation, Chronic Active | | 2 3.5| Periovarian Tissue, Infiltration | | | Cellular, Lymphocyte | | 1 3.0| __________________________________________________________________________|____________| Oviduct | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 3000 PPM | 7| | L | | 9| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Uterus | + | 50 | Dilatation | | 7 3.4| Hyperplasia, Cystic | 3 | 38 2.2| __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 50 | Myeloid Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | | 9 | Mediastinal, Hyperplasia, Plasma Cell| | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 49 | Hyperplasia, Lymphoid | | 4 2.8| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 48 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Spleen | + | 50 | Hematopoietic Cell Proliferation | | 14 2.3| Hyperplasia, Lymphoid | | 3 1.7| Pigmentation, Hemosiderin | | 1 2.0| Capsule, Inflammation, Chronic Active| | 1 3.0| __________________________________________________________________________|____________| Thymus | + | 42 | Atrophy | | 6 3.2| Ectopic Parathyroid Gland | | 1 | Hyperplasia, Lymphoid | | 4 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 50 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Skin | + | 50 | Inflammation, Chronic Active | 3 | 5 1.6| Epidermis, Hyperplasia | | 1 1.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | | 1 3.0| Subcutaneous Tissue, Fat, Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 50 | Dysplasia | 1 | 6 1.3| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 3| | | | 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| | O | B6C3F1 MICE FEMALE | 0| | T | ANIMAL ID | 4| | A | 3000 PPM | 7| | L | | 9| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + | 50 | Compression | | 1 3.0| Mineralization | 1 | 10 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 50 | Infiltration Cellular, Lymphocyte | | 20 1.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + | 50 | Olfactory Epithelium, Degeneration, | | | Hyaline | | 41 1.9| __________________________________________________________________________|____________| Trachea | + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | Inflammation, Chronic Active | | 2 3.5| Cornea, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 3 | Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 50 | Atrophy | | 1 4.0| Hemorrhage | | 1 4.0| Hydronephrosis | | 1 1.0| Infarct | | 2 1.5| Inflammation, Chronic | | 13 1.0| Nephropathy | | 1 1.0| Capsule, Inflammation, Chronic Active| | 1 2.0| Glomerulus, Inflammation, Chronic | | 1 2.0| Perirenal Tissue, Inflammation, | | | Chronic Active | | 1 3.0| Renal Tubule, Degeneration, Hyaline | | 1 3.0| Renal Tubule, Pigmentation | | 1 2.0| Renal Tubule, Regeneration | | 19 1.2| __________________________________________________________________________|____________| Urinary Bladder | + | 50 | Infiltration Cellular, Lymphocyte | 1 | 36 1.1| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3| | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M M + + + M M + + + + A + + M + M + + + + + + M +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 3 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 3 X X | Clear Cell Focus | X X 1 X X X | Eosinophilic Focus | 3 2 X 2 3 | Fatty Change, Focal | 1| Hematopoietic Cell Proliferation | | Inflammation, Chronic Active | | Mitotic Alteration | | Mixed Cell Focus | X | Necrosis | 2 | Centrilobular, Cytomegaly | 1 1 1 | Centrilobular, Fatty Change | 1 4 1 | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Acinar Cell, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Tooth | + + + + + + + | Developmental Malformation | X X X X X X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy, Focal | 1 2 3 2 2 1 1 2 1 1 1 2 1| Extra Adrenal Tissue, Inflammation, | | Chronic Active | | Subcapsular, Hyperplasia | 1 3 1 1 1 3 4 1 1 1 1 1 1 2 2 1 1 2| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3| | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 2 1 | __________________________________________________________________________| Parathyroid Gland | + + M + + + M M + + + M + + + + + + + M + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Pars Distalis, Cyst | 2 | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia, Focal | 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Inflammation, Chronic Active | 1 2 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Abscess | 4 | Dilatation | 3 3 2 4 2 2 2 2 3 3 3 2 2 3 4 1 4 2 2 3 2| Inflammation, Chronic | 2 | Inflammation, Chronic Active | 3 1 2 2 3 4 3 1 2 1 | __________________________________________________________________________| Prostate | M M + + + + + + + + + + + + + + + M + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 2 2 3 3 2 3 2 2| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + M M M + M + + + + M + + + + + M + + M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 | Hemorrhage | 2 2 2 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 3 3 1 4 | Inflammation, Chronic Active | | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + M + + + + + + + + M +| Atrophy | 3 3 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3| | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 | Inflammation, Chronic Active | 2 4 | Epidermis, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4 | Mineralization | 3 2 2 2 2 1 1 1 1 1 1 2 1 1 2 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Infiltration Cellular, Lymphocyte | 1 1 2 1 1| Infiltration Cellular, Histiocyte | 2 2 | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 1 2 2 | Bronchiole, Hyperplasia | 2 | Interstitium, Inflammation, Chronic | | Active | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 2 2 2 2 2 2 2 1 2 2 2 2 1 1 1 | Respiratory Epithelium, Hyperplasia, | | Glandular | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | | Hypertrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Inflammation, Chronic | 1 1 1 | Inflammation, Chronic Active | | Metaplasia, Osseous | 2 1 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3| | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Nephropathy | 1 1 2 1 1 1 1 1 2 3 2 1 1 1 2 1 2 2 2 2 1 2 2| Renal Tubule, Degeneration, Hyaline | | Renal Tubule, Hyperplasia | 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| | | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + + + + + + + + + + + M + + + +| 47 | __________________________________________________________________________|____________| Gallbladder | + + + + M M M + + + + + + M M + + + M M M + + + +| 34 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 2 3.5| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 3 3.0| Clear Cell Focus | X | 7 1.0| Eosinophilic Focus | 1 2 X | 8 2.2| Fatty Change, Focal | 1 1 1 | 4 1.0| Hematopoietic Cell Proliferation | 1 1 | 2 1.0| Inflammation, Chronic Active | 1 1 | 2 1.0| Mitotic Alteration | 1 | 1 1.0| Mixed Cell Focus | | 1 | Necrosis | 1 | 2 1.5| Centrilobular, Cytomegaly | | 3 1.0| Centrilobular, Fatty Change | | 3 2.0| __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | 1 | 1 1.0| Acinar Cell, Atrophy | 4 2 | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1| 22 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 1 | 2 1.0| __________________________________________________________________________|____________| Tooth | + + | 9 | Developmental Malformation | X X | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| | | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Hypertrophy, Focal | 1 2 1 1 2 1 2 1 2 2| 23 1.5| Extra Adrenal Tissue, Inflammation, | | | Chronic Active | 3 | 1 3.0| Subcapsular, Hyperplasia | 1 1 1 2 2 1 1 1 1 1 1 1 1 | 31 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 7 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + M + + + + + + + M M M + + + M M M + +| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + + + I + + + + + + + + + M + +| 46 | Pars Distalis, Cyst | | 1 2.0| Pars Distalis, Hyperplasia | 2 1 | 3 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Follicular Cell, Hyperplasia, Focal | 1 2 1 | 7 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| Inflammation, Chronic Active | 2 1| 5 1.4| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Abscess | | 1 4.0| Dilatation | 4 2 3 3 3 1 4 2 1 4 3 4 3 2 1 1 3 4 4| 40 2.7| Inflammation, Chronic | 2 | 2 2.0| Inflammation, Chronic Active | 4 4 1 3 1 2 3 1 1 1 1 2 1 | 23 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 | Inflammation, Chronic | 1 1 1 1 1 1| 11 1.0| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 | 10 2.4| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + + + + + + +| 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| | | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 | 5 2.0| Hemorrhage | 4 3 3 2 2 2| 13 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 1 1 3 3 2 2 3 3 | 14 2.3| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + M + + + M + + M + +| 43 | Atrophy | 2 4 | 5 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M + M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 2.0| Inflammation, Chronic Active | | 2 3.0| Epidermis, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 1 4.0| Mineralization | 2 3 2 3 2 2 2 2 3 2 1 1 1 2 2 2 | 33 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Infiltration Cellular, Lymphocyte | 1 1 1 | 8 1.1| Infiltration Cellular, Histiocyte | | 2 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 3 3 1| 6 2.0| Bronchiole, Hyperplasia | | 1 2.0| Interstitium, Inflammation, Chronic | | | Active | 2 | 2 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | | 1 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 1 2 2 1 2 2 | 23 1.7| Respiratory Epithelium, Hyperplasia, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| | | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Glandular | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 3 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Hypertrophy | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 | 2 1.0| Inflammation, Chronic | 1 1 1 1 1 | 8 1.0| Inflammation, Chronic Active | 4 1 | 2 2.5| Metaplasia, Osseous | | 2 1.5| Nephropathy | 1 2 2 1 1 1 1 1 1 1 2 1 1 2 2 1 2 2 1 2 1 2| 45 1.5| Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0| Renal Tubule, Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Lymphocyte | 1 1 1 1 1| 13 1.0| Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CODEINE Date: 02/24/95 Route: DOSED FEED Time: 14:12:53 _____________________________________________________________________________________________________________________ | 3| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| DAY ON TEST | 9| 2| 3| 9| 2| 3| 3| 0| 3| 3| 3| 3| 2| 1| 3| 2| 3| 2| 3| 2| 7| 3| 2| 5| 3| | 6| 9| 0| 7| 9| 1| 1| 3| 1| 1| 0| 0| 9| 6| 1| 5| 1| 9| 1| 9| 4| 1| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 750 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | 1| 2| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + M + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + M + M + + + + + + + + + + + M + + + + + + +| Degeneration, Hyaline | 2 | Dilatation | 2 | Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Plasma Cell | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | X X | Cyst | 4 | Eosinophilic Focus | 2 X 2 3 | Fatty Change, Focal | 1 | Infarct | 4 2 | Inflammation, Chronic Active | 1 1 | Mitotic Alteration | | Mixed Cell Focus | | Necrosis | 3 2 3 | Pigmentation | | Centrilobular, Fatty Change | 2 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 4 | __________________________________________________________________________| Pancreas