TDMS Study 05068-10 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. CODEINE DATE: 04/03/96
EXPERIMENT: 05068 TEST: 10 TIME: 02:01:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75178 ROUTE: DOSED FEED NTP C#: 61541B
PATHOLOGIST: MISSING CAS: 76-57-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. CODEINE DATE: 04/03/96
EXPERIMENT: 05068 TEST: 10 TIME: 02:01:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75178 ROUTE: DOSED FEED NTP C#: 61541B
PATHOLOGIST: MISSING CAS: 76-57-3
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 227 450 497 546 579 609 629 689 693 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 11 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 8 396 474 559 566 603 622 633 697 716 |
| 725 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 724 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 5 CENSORED DEATHS 10 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 9 635 667 718 727 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 9 401 500 537 652 697 726 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.3 98.3 98.3 96.7 94.7 90.6 86.6 82.6 |
| | |
| | |
|750 PPM | 98.3 98.3 98.3 98.3 96.7 94.7 94.7 88.6 84.6 78.5 |
| | |
| | |
|1500 PPM | 98.3 98.3 98.3 98.3 98.3 98.3 98.3 98.3 96.3 90.3 |
| | |
| | |
|3000 PPM | 98.3 98.3 98.3 98.3 96.7 96.7 92.6 92.6 90.6 86.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 750 PPM 1500 PPM 3000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.6% 78.5% 90.3% 86.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.417N P=0.810 P=0.350N P=0.766N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 546.6 545.4 551.2 503.1 |
|NATURAL DEATHS (C) | (48.2) (61.6) ( 137) (93.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.1 649.8 668.7 657.2 |
|(STANDARD ERROR) | (15.9) (18.1) (17.3) (18.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 9 272 497 530 544 565 570 582 591 651 |
| 659 695 713 722 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 9 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 8 8 348 359 388 479 512 539 616 625 |
| 633 647 664 672 677 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 9 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 8 323 329 643 703 724 727 727 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 8 8 397 506 556 598 619 631 680 711 |
| 711 720 722 727 728 |
| CENSORED DEATHS |
| 430 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
CODEINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.3 98.3 98.3 96.7 96.7 96.7 90.6 82.6 78.5 72.5 |
| | |
| | |
|750 PPM | 96.7 96.7 96.7 93.3 91.7 89.7 85.7 85.7 75.7 71.7 |
| | |
| | |
|1500 PPM | 98.3 98.3 98.3 95.0 95.0 95.0 95.0 95.0 93.0 85.1 |
| | |
| | |
|3000 PPM | 96.7 96.7 96.7 96.7 95.0 95.0 93.0 88.9 84.9 70.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 750 PPM 1500 PPM 3000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.5% 71.7% 85.1% 70.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.979N P=0.945 P=0.185N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 542.9 478.3 523.0 554.8 |
|NATURAL DEATHS (C) | (51.1) (57.4) (95.7) (62.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.4 626.7 662.2 640.8 |
|(STANDARD ERROR) | (18.7) (21.7) (18.8) (21.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CODEINE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
750 PPM = 2
1500 PPM = 3
3000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 2 1
|
|
| 2 1 24 1 3
97.5 +
| 24 1 2 14
| 3 3
|
95.0 +
| 2 14 41 2 3 3
P |
E |
R 92.5 + 41 22 1 4 33
C |
E |
N | 2 1 1 4 4
T 90.0 + 3 3
|
S | 1 21 4 4
U |
R 87.5 +
V | 212 1 4 4
I |
V |
A 85.0 +
L | 2 2
|
|
82.5 + 12 2 1
|
|
| 22
80.0 +
|
| 2 2
|
77.5 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
CODEINE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
750 PPM = 2
1500 PPM = 3
3000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1
| 1 1 3
|
| 2 1 2 4 1
P 95 + 3 2 2 4 1 4 1 3
E | 2 2
R | 4 1 1 4 3 3
C | 2 2 1 41 4 3 3
E 90 + 2 2
N | 11 4 4
T | 2 2 4 4
| 2 1 1 2
S 85 + 1 1 4 4 3 3
U | 2 2
R | 1 1 4 4
V | 22
I 80 + 2 1 1
V | 1 1 44
A | 2 2
L | 22 1 144
75 + 1 1
| 22
| 1 1
| 2 4 2
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.