National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2814

TDMS Study 05068-09 Pathology Tables

NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96
Route: DOSED FEED                                                                                                 Time: 13:25:35




       Facility:  Microbiological Associates

       Chemical CAS #:  76-57-3

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10            9            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15            9           17           14                                     
    Natural Death                                      7            3            5            5                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1            1                                                  
    Terminal Sacrifice                                28           37           28           32                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Inflammation                                     1 (2%)                                                                       
      Intussusception                                               1 (2%)                                                          
   Intestine Large, Cecum                             (60)         (58)         (59)         (59)                                   
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                47 (78%)     42 (70%)     33 (55%)     32 (53%)                               
      Clear Cell Focus                                 5 (8%)       4 (7%)                    2 (3%)                                
      Congestion                                                                 1 (2%)       3 (5%)                                
      Degeneration                                     1 (2%)                                                                       
      Developmental Malformation                       4 (7%)       2 (3%)                    1 (2%)                                
      Eosinophilic Focus                               5 (8%)       3 (5%)       3 (5%)       1 (2%)                                
      Fatty Change                                    10 (17%)      4 (7%)       4 (7%)       3 (5%)                                
      Hematopoietic Cell Proliferation                 2 (3%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       3 (5%)       5 (8%)       5 (8%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Inflammation                                     4 (7%)       4 (7%)      10 (17%)      9 (15%)                               
      Leukocytosis                                     1 (2%)                    1 (2%)       1 (2%)                                
      Mixed Cell Focus                                                           1 (2%)                                             
      Necrosis                                         2 (3%)                    4 (7%)                                             
      Bile Duct, Hyperplasia, Focal                    1 (2%)                                                                       
      Centrilobular, Degeneration                                                1 (2%)                                             
   Mesentery                                          (8)          (5)          (6)          (3)                                    
      Infiltration Cellular, Lymphocyte                1 (13%)                                                                      
      Fat, Inflammation                                             1 (20%)                                                         
      Fat, Necrosis                                    7 (88%)      3 (60%)      5 (83%)      3 (100%)                              
      Lymphatic, Cyst                                  1 (13%)                                                                      
   Oral Mucosa                                        (3)                                    (1)                                    
      Gingival, Cyst                                   1 (33%)                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Accessory Spleen                                                                        1 (2%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       2 (3%)                                             
      Inflammation                                     2 (3%)       1 (2%)       1 (2%)                                             
      Acinar Cell, Atrophy                            27 (45%)     14 (23%)     22 (37%)     27 (45%)                               
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
      Artery, Inflammation                                          1 (2%)                                                          
   Pharynx                                                                      (1)                                                 
      Palate, Hyperplasia                                                        1 (100%)                                           
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
      Atrophy, Focal                                   1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (59)                                   
      Hyperplasia                                      3 (5%)       4 (7%)       3 (5%)       3 (5%)                                
      Inflammation                                     2 (3%)       1 (2%)       1 (2%)                                             
      Ulcer                                            2 (3%)                    4 (7%)       5 (8%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Fibrosis, Focal                                                                         1 (2%)                                
      Necrosis                                                      3 (5%)                    2 (3%)                                
      Ulcer                                                                      3 (5%)       1 (2%)                                
   Tongue                                                                                    (1)                                    
      Inflammation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  12 (20%)      8 (13%)     15 (25%)      9 (15%)                               
      Hypertrophy                                                   1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Atrium, Dilatation                                                         1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)                                             
      Coronary Artery, Inflammation                                              1 (2%)                                             
      Valve, Inflammation, Chronic                                               1 (2%)                                             
      Valve, Pigmentation                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Angiectasis                                     13 (22%)      6 (10%)      6 (10%)      3 (5%)                                
      Congestion                                                                 1 (2%)                                             
      Cytologic Alterations                            1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration                                                                  2 (3%)                                
      Degeneration                                                                            1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia, Focal                               1 (2%)       9 (15%)      8 (13%)      3 (5%)                                
      Hypertrophy                                      2 (3%)       1 (2%)                    1 (2%)                                
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                                                               2 (3%)                                
      Vacuolization Cytoplasmic, Focal                 7 (12%)      6 (10%)      4 (7%)       8 (13%)                               
      Capsule, Inflammation                                                                   1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      8 (13%)      5 (8%)       2 (3%)       2 (3%)                                
      Hyperplasia, Focal                                                                      1 (2%)                                
      Infiltration Cellular, Lymphocyte                2 (3%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (53)         (44)         (47)         (52)                                   
      Hyperplasia                                                   3 (7%)                                                          
   Pituitary Gland                                    (56)         (60)         (59)         (60)                                   
      Developmental Malformation                                                              1 (2%)                                
      Pars Distalis, Angiectasis                      13 (23%)      7 (12%)     11 (19%)      7 (12%)                               
      Pars Distalis, Cyst                             16 (29%)     17 (28%)     17 (29%)     15 (25%)                               
      Pars Distalis, Hyperplasia                      16 (29%)     19 (32%)     16 (27%)     15 (25%)                               
      Pars Distalis, Hyperplasia, Focal                2 (4%)       1 (2%)                                                          
      Pars Distalis, Pigmentation                                                             1 (2%)                                
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                              4 (7%)      11 (18%)      5 (8%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (57)         (59)         (60)                                   
      Ectasia                                          6 (11%)      9 (16%)      7 (12%)     21 (35%)                               
      Hyperplasia                                      9 (16%)      8 (14%)      9 (15%)      6 (10%)                               
      Inflammation                                     1 (2%)                    1 (2%)       3 (5%)                                
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                             8 (13%)      4 (7%)       5 (8%)       4 (7%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Corpus Luteum, Hypertrophy                                                              1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Dilatation                                       4 (7%)       1 (2%)       7 (12%)      5 (8%)                                
      Fibrosis                                                                   1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                       1 (2%)                    2 (3%)       1 (2%)                                
      Endometrium, Hyperplasia                                                                2 (3%)                                
   Vagina                                                                       (2)          (1)                                    
      Inflammation                                                               1 (50%)      1 (100%)                              
      Prolapse                                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      2 (3%)       5 (8%)       8 (13%)      7 (12%)                               
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Myelofibrosis                                                                           1 (2%)                                
      Erythroid Cell, Atrophy                          1 (2%)                                                                       
      Erythroid Cell, Hyperplasia                      1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                                                               1 (2%)                                
   Lymph Node                                         (12)         (10)         (9)          (11)                                   
      Iliac, Hyperplasia, Plasma Cell                  1 (8%)                                                                       
      Mediastinal, Cyst                                1 (8%)                                                                       
      Mediastinal, Hemorrhage                          6 (50%)      2 (20%)      2 (22%)      4 (36%)                               
      Mediastinal, Pigmentation                        3 (25%)      2 (20%)      2 (22%)      2 (18%)                               
      Pancreatic, Pigmentation                                      1 (10%)                                                         
      Renal, Hemorrhage                                                          2 (22%)                                            
      Renal, Pigmentation                                                        1 (11%)                                            
   Lymph Node, Mandibular                             (58)         (59)         (58)         (58)                                   
      Congestion                                                                 1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Hemorrhage                                       2 (3%)       3 (5%)       4 (7%)       3 (5%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                         2 (3%)                    1 (2%)       3 (5%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (59)         (58)         (60)                                   
      Edema                                            1 (2%)       2 (3%)                                                          
      Hemorrhage                                       1 (2%)                                 2 (3%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    3 (5%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       1 (2%)                    1 (2%)                                
      Depletion Lymphoid                               1 (2%)                                                                       
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 5 (8%)       2 (3%)       5 (8%)       6 (10%)                               
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                                      1 (2%)                    1 (2%)                                
      Pigmentation                                                               2 (3%)       2 (3%)                                
   Thymus                                             (52)         (56)         (56)         (54)                                   
      Amyloid Deposition                                            1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                         30 (58%)     34 (61%)     26 (46%)     25 (46%)                               
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                       2 (4%)       1 (2%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (59)         (60)                                   
      Dilatation                                                                 1 (2%)                                             
      Galactocele                                      1 (2%)       2 (3%)       3 (5%)                                             
      Hyperplasia                                      8 (13%)      7 (12%)      7 (12%)      8 (13%)                               
      Infiltration Cellular, Histiocyte                             1 (2%)       3 (5%)                                             
      Inflammation                                                               1 (2%)                                             
      Lactation                                       14 (23%)     23 (38%)     24 (41%)     16 (27%)                               
   Skin                                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                                    1 (2%)                                                          
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                 1 (2%)                                                          
      Tail, Fibrosis                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Cranium, Hyperostosis                            2 (3%)       3 (5%)       3 (5%)       3 (5%)                                
      Femur, Hyperostosis                              3 (5%)       6 (10%)      3 (5%)       3 (5%)                                
      Maxilla, Hyperostosis                                                      1 (2%)                                             
      Turbinate, Hyperostosis                          2 (3%)       2 (3%)       4 (7%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      8 (13%)      4 (7%)      10 (17%)      4 (7%)                                
      Degeneration, Focal                                                        1 (2%)                                             
      Hemorrhage                                                    2 (3%)       2 (3%)       1 (2%)                                
      Hydrocephalus                                    2 (3%)       1 (2%)       4 (7%)       1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Meninges, Inflammation, Focal                                              1 (2%)                                             
      Meninges, Thrombosis, Focal                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                                 2 (3%)       1 (2%)                                
      Hemorrhage                                                    2 (3%)       3 (5%)                                             
      Infiltration Cellular, Lymphocyte                3 (5%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                7 (12%)      8 (13%)      9 (15%)     17 (28%)                               
      Inflammation                                     7 (12%)     12 (20%)      8 (13%)     15 (25%)                               
      Leukocytosis                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (3%)       2 (3%)       2 (3%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Cytoplasmic Alteration                                                     1 (2%)                                             
      Edema, Focal                                                               2 (3%)       1 (2%)                                
      Foreign Body                                                               1 (2%)                                             
      Fungus                                           1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte                                                1 (2%)                                
      Inflammation                                     4 (7%)       7 (12%)      8 (13%)      5 (8%)                                
      Thrombosis                                                                              1 (2%)                                
      Nares, Hyperplasia                                                                      1 (2%)                                
      Nasolacrimal Duct, Inflammation                               1 (2%)       3 (5%)       3 (5%)                                
      Olfactory Epithelium, Atrophy, Focal                                       2 (3%)       1 (2%)                                
      Olfactory Epithelium, Cytoplasmic Alteration    46 (77%)     55 (92%)     51 (85%)     57 (95%)                               
      Respiratory Epithelium, Hyperplasia                                        2 (3%)                                             
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)          (5)                                    
      Hemorrhage                                                                 1 (100%)     1 (20%)                               
      Phthisis Bulbi                                                                          1 (20%)                               
      Cornea, Inflammation                                                                    1 (20%)                               
      Lens, Cataract                                   1 (100%)     1 (100%)                  2 (40%)                               
      Lens, Hyperplasia                                1 (100%)                                                                     
      Retina, Atrophy                                               1 (100%)                                                        
      Retina, Degeneration                                                       1 (100%)     2 (40%)                               
   Harderian Gland                                                              (1)          (1)                                    
      Infiltration Cellular, Lymphocyte                                                       1 (100%)                              
      Inflammation                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Infarct                                          1 (2%)       4 (7%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
      Inflammation                                                                            1 (2%)                                
      Mineralization                                   4 (7%)       2 (3%)                    1 (2%)                                
      Necrosis                                                                   1 (2%)       2 (3%)                                
      Nephropathy, Chronic                            46 (77%)     51 (85%)     49 (82%)     45 (75%)                               
      Bilateral, Hydronephrosis                                                  1 (2%)                                             
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
   Urinary Bladder                                    (60)         (59)         (59)         (59)                                   
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           23           24           23                                     
    Natural Death                                      7            7            5            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           20           21           20                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (59)         (58)         (60)         (60)                                   
      Inflammation                                                  1 (2%)                                                          
      Pigmentation                                                                            1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (56)         (58)         (57)         (56)                                   
      Diverticulum                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Small, Ileum                             (56)         (56)         (57)         (57)                                   
      Cyst                                             1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Angiectasis                                      3 (5%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                22 (37%)     19 (32%)     26 (43%)     21 (35%)                               
      Clear Cell Focus                                 5 (8%)       1 (2%)       2 (3%)       1 (2%)                                
      Congestion                                       2 (3%)       1 (2%)                                                          
      Degeneration                                                  3 (5%)       1 (2%)       2 (3%)                                
      Degeneration, Cystic                            14 (23%)      5 (8%)       1 (2%)                                             
      Developmental Malformation                       2 (3%)                    1 (2%)                                             
      Eosinophilic Focus                               7 (12%)      1 (2%)       6 (10%)      4 (7%)                                
      Fatty Change                                                  5 (8%)       1 (2%)       1 (2%)                                
      Fibrosis                                         3 (5%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (5%)       4 (7%)       3 (5%)       1 (2%)                                
      Hyperplasia, Focal                                                                      1 (2%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Leukocytosis                                                                            1 (2%)                                
      Mixed Cell Focus                                 4 (7%)                                 1 (2%)                                
      Necrosis                                         2 (3%)       3 (5%)       1 (2%)       1 (2%)                                
      Thrombosis                                       1 (2%)       1 (2%)       4 (7%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Fibrosis                                                        1 (2%)                                             
      Bile Duct, Hyperplasia                           1 (2%)       5 (8%)       3 (5%)       1 (2%)                                
   Mesentery                                          (13)         (24)         (24)         (21)                                   
      Fat, Necrosis                                   12 (92%)     24 (100%)    22 (92%)     19 (90%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Accessory Spleen                                 1 (2%)                    2 (3%)                                             
      Amyloid Deposition                                                         1 (2%)                                             
      Ectopic Liver                                                 1 (2%)                    1 (2%)                                
      Edema                                                                      1 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)       1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Acinar Cell, Atrophy                            30 (50%)     33 (55%)     34 (57%)     27 (45%)                               
      Artery, Inflammation                                                       1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Atrophy                                                                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                                                      1 (2%)                                             
      Hyperkeratosis, Focal                                         1 (2%)                                                          
      Hyperplasia                                      3 (5%)       4 (7%)       2 (3%)       4 (7%)                                
      Ulcer                                            3 (5%)       3 (5%)       2 (3%)       1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Necrosis                                         1 (2%)       3 (5%)       1 (2%)       2 (3%)                                
      Ulcer                                                         4 (7%)       2 (3%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  39 (65%)     31 (52%)     31 (52%)     32 (53%)                               
      Mineralization, Focal                                         1 (2%)                                                          
      Atrium, Dilatation                                            1 (2%)       1 (2%)       1 (2%)                                
      Atrium, Thrombosis                               2 (3%)       2 (3%)       5 (8%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Angiectasis                                      6 (10%)      7 (12%)     11 (18%)     20 (33%)                               
      Cytologic Alterations                            1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       3 (5%)       2 (3%)                                
      Hyperplasia, Focal                               3 (5%)       6 (10%)      2 (3%)       6 (10%)                               
      Hypertrophy                                                   1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Vacuolization Cytoplasmic, Focal                              4 (7%)       6 (10%)                                            
   Adrenal Medulla                                    (59)         (60)         (59)         (60)                                   
      Hyperplasia                                     25 (42%)     12 (20%)     11 (19%)      9 (15%)                               
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       2 (3%)                                             
   Parathyroid Gland                                  (48)         (51)         (52)         (53)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (58)         (57)                                   
      Congestion                                       1 (2%)                                                                       
      Pars Distalis, Angiectasis                       7 (12%)      1 (2%)       3 (5%)       3 (5%)                                
      Pars Distalis, Cyst                              2 (3%)       6 (10%)      3 (5%)       2 (4%)                                
      Pars Distalis, Degeneration                      1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                9 (15%)     17 (28%)     11 (19%)      8 (14%)                               
      Pars Intermedia, Angiectasis                     2 (3%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)                                                          
      Pars Nervosa, Developmental Malformation                                                1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Hyperplasia                              4 (7%)       4 (7%)       6 (10%)      5 (8%)                                
      Follicle, Atrophy                                             1 (2%)                                                          
      Follicle, Cyst                                                                          1 (2%)                                
      Follicle, Dilatation                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Mediastinum, Infiltration Cellular,                                                                                           
          Lymphocyte                                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (59)                                   
      Edema, Focal                                                  1 (2%)                                                          
      Granuloma Sperm                                               1 (2%)                                                          
      Hypoplasia                                                    1 (2%)                                                          
      Hypospermia                                     33 (55%)     35 (58%)     39 (66%)     34 (58%)                               
   Penis                                                                        (1)          (1)                                    
      Angiectasis                                                                1 (100%)                                           

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                                              1 (100%)                              
      Inflammation                                                               1 (100%)                                           
   Preputial Gland                                    (59)         (60)         (58)         (59)                                   
      Atrophy                                          2 (3%)                                                                       
      Depletion Cellular                                                         1 (2%)                                             
      Ectasia                                          1 (2%)      10 (17%)      6 (10%)      4 (7%)                                
      Hyperplasia                                      3 (5%)       2 (3%)       5 (9%)      11 (19%)                               
      Inflammation                                    11 (19%)      4 (7%)       4 (7%)       9 (15%)                               
   Prostate                                           (59)         (59)         (60)         (60)                                   
      Atrophy                                          3 (5%)       5 (8%)       3 (5%)                                             
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Dilatation                                                                 1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Focal                               4 (7%)       2 (3%)                    2 (3%)                                
      Infiltration Cellular, Focal, Lymphocyte                      2 (3%)                                                          
      Inflammation                                     7 (12%)     12 (20%)      9 (15%)      3 (5%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Depletion Cellular                              35 (58%)     42 (70%)     40 (67%)     42 (70%)                               
      Dilatation                                                    1 (2%)                                                          
      Ectasia                                                                    2 (3%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
   Testes                                             (60)         (60)         (60)         (60)                                   
      Atrophy                                          4 (7%)       4 (7%)       1 (2%)       1 (2%)                                
      Congestion, Focal                                                          1 (2%)                                             
      Bilateral, Atrophy                               3 (5%)       1 (2%)                                                          
      Interstitial Cell, Hyperplasia, Focal            5 (8%)       5 (8%)       5 (8%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      6 (10%)      8 (13%)      5 (8%)       1 (2%)                                
      Myelofibrosis                                                                           1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Erythroid Cell, Hyperplasia                      4 (7%)                    2 (3%)       3 (5%)                                
      Myeloid Cell, Atrophy                                                                   1 (2%)                                
      Myeloid Cell, Hyperplasia                                     1 (2%)                                                          
   Lymph Node                                         (20)         (17)         (15)         (22)                                   
      Lumbar, Pigmentation                                                                    1 (5%)                                
      Mediastinal, Hemorrhage                          2 (10%)      2 (12%)      2 (13%)      2 (9%)                                
      Mediastinal, Pigmentation                        1 (5%)                    2 (13%)      2 (9%)                                
      Pancreatic, Lymphocyte, Hyperplasia                                                     1 (5%)                                
   Lymph Node, Mandibular                             (60)         (59)         (59)         (59)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Amyloid Deposition                                                         1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                       3 (5%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)                                                          
      Hyperplasia, Plasma Cell                         1 (2%)       1 (2%)       5 (8%)       4 (7%)                                
      Lymphocyte, Hyperplasia                                                                 1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Cyst                                                          2 (3%)                                                          
      Cyst, Multiple                                                             1 (2%)                                             
      Erythrophagocytosis                              1 (2%)       1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)                    1 (2%)                                
      Pigmentation                                                  1 (2%)                    1 (2%)                                
      Lymphocyte, Hyperplasia                                                                 1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       2 (3%)                    1 (2%)                                
      Developmental Malformation                       4 (7%)       1 (2%)                                                          
      Fibrosis                                         2 (3%)       3 (5%)       2 (3%)       2 (3%)                                
      Hematopoietic Cell Proliferation                 3 (5%)       4 (7%)       2 (3%)       3 (5%)                                
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Necrosis                                                      1 (2%)       2 (3%)                                             
      Pigmentation                                                                            1 (2%)                                
      Lymphocyte, Hyperplasia                                                                 1 (2%)                                
   Thymus                                             (56)         (51)         (49)         (50)                                   
      Atrophy                                         38 (68%)     34 (67%)     29 (59%)     31 (62%)                               
      Depletion Cellular                               1 (2%)                                                                       
      Hemorrhage                                       3 (5%)       2 (4%)                    1 (2%)                                
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (59)         (60)         (56)                                   
      Fibrosis                                                                                1 (2%)                                
      Galactocele                                                                1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Lactation                                        7 (12%)                   4 (7%)       2 (4%)                                
      Pigmentation                                     2 (4%)       2 (3%)       1 (2%)       6 (11%)                               
   Skin                                               (60)         (60)         (60)         (59)                                   
      Acanthosis                                       1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation                                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Ulcer                                                         1 (2%)                                                          
      Hair Follicle, Atrophy                           1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation                                                       1 (2%)                                
      Tail, Acanthosis, Focal                          1 (2%)                                                                       
      Tail, Inflammation                                            1 (2%)                                                          
      Tail, Necrosis                                                1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                                  1 (2%)                                                          
      Rib, Developmental Malformation, Focal           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                                   1 (2%)                    1 (2%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Cerebellum, Necrosis, Focal                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Fibrosis, Focal                                               1 (2%)                                                          
      Hemorrhage                                       2 (3%)       2 (3%)       2 (3%)       1 (2%)                                
      Infiltration Cellular, Focal, Histiocyte         6 (10%)      2 (3%)       3 (5%)       6 (10%)                               
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation                                     4 (7%)       5 (8%)       7 (12%)     11 (18%)                               
      Leukocytosis                                                  1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          3 (5%)                                                                       
   Nose                                               (60)         (60)         (60)         (60)                                   
      Angiectasis                                                                2 (3%)       1 (2%)                                
      Edema, Focal                                                               1 (2%)       1 (2%)                                
      Foreign Body                                     3 (5%)       2 (3%)       2 (3%)                                             
      Fungus                                           5 (8%)       5 (8%)       2 (3%)       1 (2%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                      2 (3%)                                                          
      Inflammation                                    14 (23%)     12 (20%)     10 (17%)      5 (8%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Thrombosis                                                                 2 (3%)       1 (2%)                                
      Cartilage, Dysplasia                             1 (2%)                                                                       
      Glands, Dilatation, Focal                                                  1 (2%)                                             
      Goblet Cell, Hyperplasia, Focal                  1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Inflammation                  1 (2%)       1 (2%)       1 (2%)                                             
      Nasopharyngeal Duct, Metaplasia, Squamous        1 (2%)                                                                       
      Olfactory Epithelium, Atrophy, Focal             3 (5%)       2 (3%)       4 (7%)       4 (7%)                                
      Olfactory Epithelium, Cytoplasmic Alteration    20 (33%)     23 (38%)     36 (60%)     57 (95%)                               
      Olfactory Epithelium, Degeneration               1 (2%)                                                                       
      Olfactory Epithelium, Hyperplasia, Focal                                                1 (2%)                                
      Olfactory Epithelium, Necrosis, Focal                                                   2 (3%)                                
      Olfactory Epithelium, Vacuolization                                                                                           
          Cytoplasmic, Focal                                        1 (2%)                                                          
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration, Focal                            1 (2%)                                 1 (2%)                                
      Respiratory Epithelium, Hyperplasia              1 (2%)                    3 (5%)                                             
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (2)          (1)                                    
      Phthisis Bulbi                                                             1 (50%)                                            
      Lens, Cataract                                   1 (100%)                               1 (100%)                              
      Retina, Degeneration                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Infarct                                                                    2 (3%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)       1 (2%)                                
      Nephropathy, Chronic                            50 (83%)     46 (77%)     44 (73%)     40 (67%)                               
      Pigmentation                                     1 (2%)       8 (13%)      4 (7%)       2 (3%)                                
      Bilateral, Hydronephrosis                                     1 (2%)                                                          
      Glomerulus, Degeneration                                      1 (2%)                                                          
      Transitional Epithelium, Hyperplasia, Focal      1 (2%)                                                                       
   Urethra                                                                      (1)                                                 
      Inflammation                                                               1 (100%)                                           
      Transitional Epithelium, Hyperplasia                                       1 (100%)                                           
   Urinary Bladder                                    (60)         (59)         (58)         (59)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Dilatation                                                    1 (2%)                    2 (3%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
      Inflammation                                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   15                                                              
NTP Experiment-Test: 05068-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 13:25:35  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)       1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   16                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.