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TDMS Study 05068-09 Pathology Tables

NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96
Route: DOSED FEED                                                                                                 Time: 14:01:23




       Facility:  Microbiological Associates

       Chemical CAS #:  76-57-3

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10            9            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15            9           17           14                                     
    Natural Death                                      7            3            5            5                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1            1                                                  
    Terminal Sacrifice                                28           37           28           32                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
   Intestine Large, Rectum                            (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Intestine Large, Cecum                             (60)         (58)         (59)         (59)                                   
   Intestine Small, Duodenum                          (60)         (60)         (60)         (59)                                   
   Intestine Small, Jejunum                           (59)         (59)         (56)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (60)         (58)         (57)         (56)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (8)          (5)          (6)          (3)                                    
   Oral Mucosa                                        (3)                                    (1)                                    
      Buccal, Squamous Cell Carcinoma                                                         1 (100%)                              
   Pancreas                                           (60)         (60)         (60)         (60)                                   
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (59)                                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)                                   
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (59)         (60)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (3%)       5 (8%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (53)         (44)         (47)         (52)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (56)         (60)         (59)         (60)                                   
      Pars Distalis, Adenoma                          17 (30%)     18 (30%)     20 (34%)     12 (20%)                               
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, Follicular Cell, Carcinoma                                                   1 (2%)                                
      C-Cell, Adenoma                                  4 (7%)       3 (5%)       5 (8%)       3 (5%)                                
      C-Cell, Carcinoma                                2 (3%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (57)         (59)         (60)                                   
      Adenoma                                          5 (9%)       5 (9%)      11 (19%)      1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                                            1 (2%)       1 (2%)                                             
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
   Oviduct                                                                      (1)                                                 
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Polyp Stromal                                    1 (2%)       7 (12%)      7 (12%)      3 (5%)                                
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                                            1 (2%)                                             
   Vagina                                                                       (2)          (1)                                    
      Squamous Cell Papilloma                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (12)         (10)         (9)          (11)                                   
      Mediastinal, Histiocytic Sarcoma                                           1 (11%)                                            
   Lymph Node, Mandibular                             (58)         (59)         (58)         (58)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (59)         (58)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (52)         (56)         (56)         (54)                                   
      Thymoma Benign                                   1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (59)         (60)                                   
      Adenoacanthoma                                                                          1 (2%)                                
      Adenocarcinoma                                   3 (5%)       2 (3%)       3 (5%)                                             
      Fibroadenoma                                    22 (37%)     20 (33%)     21 (36%)      6 (10%)                               
      Fibroadenoma, Multiple                           5 (8%)       1 (2%)       6 (10%)      2 (3%)                                
   Skin                                               (60)         (60)         (59)         (60)                                   
      Keratoacanthoma                                               1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (3%)                    3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Tail, Keratoacanthoma                                                      1 (2%)                                             
      Tail, Schwannoma Malignant                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Benign                               1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)       1 (2%)                                                          
   Spinal Cord                                                     (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 1 (2%)                                
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
      Nasolacrimal Duct, Squamous Cell Carcinoma                                 1 (2%)                                             
   Trachea                                            (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)                                                 
      Pinna, Schwannoma Malignant                                                2 (100%)                                           
   Zymbal's Gland                                                  (1)          (3)          (1)                                    
      Carcinoma                                                     1 (100%)     3 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Lipoma                                                        1 (2%)                                                          
      Nephroblastoma                                                             1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (60)         (59)         (59)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            15 (25%)     16 (27%)     18 (30%)     12 (20%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        400 PPM      800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          46          50          37                                       
     Total Primary Neoplasms                           93          86         115          51                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          42          44          27                                       
     Total Benign Neoplasms                            64          65          80          32                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          19          28          17                                       
     Total Malignant Neoplasms                         29          21          35          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           1                                                   
     Total Metastatic Neoplasm                          1           5           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1           1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           23           24           23                                     
    Natural Death                                      7            7            5            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           20           21           20                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
      Polyp Adenomatous, Multiple                      1 (2%)                                                                       
   Intestine Large, Rectum                            (59)         (58)         (60)         (60)                                   
   Intestine Large, Cecum                             (57)         (58)         (59)         (60)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (58)         (59)         (60)         (58)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Intestine Small, Jejunum                           (56)         (58)         (57)         (56)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (56)         (56)         (57)         (57)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Mesentery                                          (13)         (24)         (24)         (21)                                   
      Sarcoma                                                                                 1 (5%)                                
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (59)         (60)         (60)         (60)                                   
   Heart                                              (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (59)         (60)         (59)         (60)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                         13 (22%)      7 (12%)      5 (8%)       3 (5%)                                
      Bilateral, Pheochromocytoma Malignant                                      1 (2%)                                             
      Bilateral, Pheochromocytoma Benign               3 (5%)                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                                       3 (5%)                                                          
   Parathyroid Gland                                  (48)         (51)         (52)         (53)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (58)         (57)                                   
      Pars Distalis, Adenoma                          10 (17%)      5 (8%)       6 (10%)      4 (7%)                                
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
      C-Cell, Adenoma                                  3 (5%)       3 (5%)       2 (3%)       1 (2%)                                
      C-Cell, Carcinoma                                2 (3%)       2 (3%)       4 (7%)       3 (5%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (59)         (59)                                   
   Penis                                                                        (1)          (1)                                    
   Preputial Gland                                    (59)         (60)         (58)         (59)                                   
      Adenoma                                          3 (5%)       6 (10%)      5 (9%)       2 (3%)                                
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, Adenoma                                                         2 (3%)                                             
   Prostate                                           (59)         (59)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   

                                                             Page   8                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           40 (67%)     45 (75%)     49 (82%)     55 (92%)                               
      Interstitial Cell, Adenoma                      13 (22%)     12 (20%)      7 (12%)      2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
   Lymph Node                                         (20)         (17)         (15)         (22)                                   
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (6%)                                                          
      Mediastinal, Sarcoma, Metastatic, Mesentery                                             1 (5%)                                
   Lymph Node, Mandibular                             (60)         (59)         (59)         (59)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
   Thymus                                             (56)         (51)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (59)         (60)         (56)                                   
      Fibroadenoma                                     1 (2%)                    1 (2%)       1 (2%)                                
   Skin                                               (60)         (60)         (60)         (59)                                   
      Keratoacanthoma                                  1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Lipoma                                                        1 (2%)                                                          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Trichoepithelioma                                                          1 (2%)                                             
      Foot, Squamous Cell Papilloma                                 1 (2%)                                                          
      Lip, Basosquamous Tumor Benign                   1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     5 (8%)       2 (3%)       3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
      Tail, Squamous Cell Papilloma                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Rib, Osteosarcoma                                                                       1 (2%)                                
   Skeletal Muscle                                                 (1)          (1)          (1)                                    
      Abdominal, Sarcoma, Metastatic, Mesentery                                               1 (100%)                              
      Back, Lipoma                                                               1 (100%)                                           
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                                         1 (100%)                                                        

                                                             Page   9                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                         1 (2%)                    1 (2%)                                
      Meningioma Malignant                             1 (2%)                                                                       
   Spinal Cord                                                     (1)                       (2)                                    
      Hemangioma                                                                              1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                2 (3%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Schwannoma Malignant, Metastatic, Ear                         1 (2%)       1 (2%)       2 (3%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Adenoma                                                       2 (3%)                                                          
      Chondroma                                                     1 (2%)                                                          
   Trachea                                            (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (1)          (2)                                    
      Schwannoma Malignant                                                                    1 (50%)                               
      Pinna, Schwannoma Malignant                                   1 (100%)     1 (100%)     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic, Mesentery                                                          1 (2%)                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (60)         (59)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            33 (55%)     27 (45%)     37 (62%)     37 (62%)                               
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Mesothelioma Malignant                           1 (2%)       2 (3%)       3 (5%)       3 (5%)                                
____________________________________________________________________________________________________________________________________

                                                             Page  11                                                               
NTP Experiment-Test: 05068-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              CODEINE                                          Date: 04/02/96  
Route: DOSED FEED                                                                                                 Time: 14:01:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        400  PPM     800 PPM      1600                                      
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            57          60          59          59                                       
     Total Primary Neoplasms                          140         129         137         125                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 56          57          57          57                                       
     Total Benign Neoplasms                            99          93          88          76                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37          33          41          41                                       
     Total Malignant Neoplasms                         41          36          49          49                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           2           4                                       
     Total Metastatic Neoplasm                                      5           4          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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